Finn Olav Levy

Professor - Avdeling for farmakologi

English version of this page

E-post f.o.levy@medisin.uio.no

Telefon +47 22840237

Mobiltelefon +47 47271676

Brukernavn

Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo

Postadresse Postboks 1057 Blindern 0316 Oslo

Last ned visittkort

Faglige interesser

Forskning om hjertesvikt, hjertefarmakologi og cellulær signaloverføring

Undervisning

Undervisning i farmakologi for medisinstudenter fra modul 3 til modul 8 (3. til 6. studieår)

Bakgrunn

Cand. med., Universitetet i Oslo 1987
Dr. med., Universitetet i Oslo 1989
Autorisasjon som lege 1990
Professor i farmakologi fra 2004

Verv

Forskningsleder, Avdeling for farmakologi

Samarbeid

Utstrakt nasjonalt og internasjonalt forskningssamarbeid vedr. hjertesvikt, hjertefarmakologi og cellulær signaloverføring

Emneord: Hjertesvikt, Farmakologi, Serotonin, G-protein, Reseptor

Andresen, Henriette; Pérez-Ternero, Cristina; Robinson, Jerid; Dickey, Deborah M.; Hobbs, Adrian J. & Potter, Lincoln R. [Vis alle 9 forfattere av denne artikkelen] (2023). Novel enhancers of guanylyl cyclase-A activity acting via allosteric modulation. British Journal of Pharmacology. ISSN 0007-1188. doi: 10.1111/bph.16203. Fulltekst i vitenarkiv
Levy, Finn Olav & Osnes, Jan-Bjørn (2023). Can acetate via FFA receptors contribute to the diabetogenic effect of statins? Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 0, s. 1–4. doi: 10.1007/s00210-023-02647-7. Fulltekst i vitenarkiv
Manfra, Ornella; Calamera, Gaia; Froese, Alexander; Arunthavarajah, Dulasi; Surdo, Nicoletta C. & Meier, Silja [Vis alle 14 forfattere av denne artikkelen] (2022). CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. Cardiovascular Research (CVR). ISSN 0008-6363. 118(6), s. 1506–1519. doi: 10.1093/cvr/cvab167. Fulltekst i vitenarkiv
Calamera, Gaia; Moltzau, Lise Roman; Levy, Finn Olav & Andressen, Kjetil Wessel (2022). Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts. International Journal of Molecular Sciences. ISSN 1661-6596. 23:2145(4), s. 1–24. doi: 10.3390/ijms23042145. Fulltekst i vitenarkiv
Danielsen, Tore Kristian; Sadredini, Mani; Manotheepan, Ravinea; Aronsen, Jan Magnus; Frisk, Michael & Hansen Haugsten, Marie [Vis alle 13 forfattere av denne artikkelen] (2021). Exercise training stabilizes RyR2-dependent Ca2+ release in post-infarction heart failure. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 7. doi: 10.3389/fcvm.2020.623922. Fulltekst i vitenarkiv
Barnes, Nicholas M.; Ahern, Gerard P.; Becamel, Carine; Bockaert, Joël; Camilleri, Michael & Chaumont-Dubel, Severine [Vis alle 39 forfattere av denne artikkelen] (2021). International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews. ISSN 0031-6997. 73(1), s. 310–520. doi: 10.1124/PR.118.015552.
Jang, Wonjo; Adams, C. Elizabeth; Liu, Heng; Zhang, Cheng; Levy, Finn Olav & Andressen, Kjetil Wessel [Vis alle 7 forfattere av denne artikkelen] (2020). An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(48), s. 30755–30762. doi: 10.1073/pnas.2010801117. Fulltekst i vitenarkiv
Calamera, Gaia; Li, Dan; Ulsund, Andrea Hembre; Kim, Jeong Joo; Neely, Oliver C. & Moltzau, Lise Roman [Vis alle 11 forfattere av denne artikkelen] (2019). FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons. Communications Biology. ISSN 2399-3642. 2:394, s. 1–12. doi: 10.1038/s42003-019-0641-x. Fulltekst i vitenarkiv
Melsom, Elin Maria Caroline Bull; Cosson, Marie-Victoire; Ørstavik, Øivind; Lai, Ngai Chin; Hammond, H. Kirk & Osnes, Jan-Bjørn [Vis alle 10 forfattere av denne artikkelen] (2019). Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. PLOS ONE. ISSN 1932-6203. 14:e021810(6), s. 1–19. doi: 10.1371/journal.pone.0218110. Fulltekst i vitenarkiv
Ndongson, Bernadin Dongmo; Lang, Guang-Ping; Mece, Odeta; Hechaichi, Nadine; Lajqi, Trim & Hoyer, Dirk [Vis alle 12 forfattere av denne artikkelen] (2019). Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice. Basic Research in Cardiology. ISSN 0300-8428. 114:26(3), s. 1–20. doi: 10.1007/s00395-019-0734-1.
Cosson, Marie-Victoire; Hiis, Halvard Gautefall; Moltzau, Lise Roman; Levy, Finn Olav & Krobert, Kurt Allen (2019). Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the ? <sub>1</sub> -adrenoceptor-mediated inotropic response . Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 131, s. 132–145. doi: 10.1016/j.yjmcc.2019.04.017.
Ulsund, Amanda Hembre; Dahl, Marie; Frimurer, Thomas; Manfra, Ornella; Schwartz, Thue W. & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2018). Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase. The FASEB Journal. ISSN 0892-6638. 33(3), s. 3870–3886. doi: 10.1096/fj.201800805RR.
Hiis, Halvard Gautefall; Cosson, Marie-Victoire; Dahl, Christen Peder; Fiane, Arnt E; Levy, Finn Olav & Andersen, Geir Øystein [Vis alle 7 forfattere av denne artikkelen] (2018). Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 315(5), s. H1137–H1147. doi: 10.1152/ajpheart.00208.2018. Fulltekst i vitenarkiv
Andressen, Kjetil Wessel; Ulsund, Andrea Hembre; Krobert, Kurt Allen; Lohse, Martin J.; Bünemann, Moritz & Levy, Finn Olav (2017). Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation. The FASEB Journal. ISSN 0892-6638. 32(2), s. 1059–1069. doi: 10.1096/fj.201700486R.
Moltzau, Lise Roman; Meier, Silja; Andressen, Kjetil Wessel & Levy, Finn Olav (2017). Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy. I Nikolaev, Viacheslav & Zaccolo, Manuela (Red.), Microdomains in the Cardiovascular System.. Springer. ISSN 978-3-319-54578-3. s. 245–271. doi: 10.1007/978-3-319-54579-0_12.
Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina & Skomedal, Tor [Vis alle 10 forfattere av denne artikkelen] (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology. ISSN 0014-2999. 812, s. 174–183. doi: 10.1016/j.ejphar.2017.07.014.
Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav & Marton, Janos [Vis alle 10 forfattere av denne artikkelen] (2017). Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers. Letters in Drug Design & Discovery. ISSN 1570-1808. 14(7), s. 787–797. doi: 10.2174/1570180813666161101152943. Vis sammendrag
Histone deacetylases (HDACs) emerged as important epigenetic regulators of gene expression. In order to identify potential positron emission tomography (PET) tracers for imaging HDACs, we evaluated in vitro and in cellulo activities of some compounds that were reported as potent HDAC2-selective inhibitors. We observed marked differences between reported activity values and the values obtained in our assays for some of the compounds. To understand the structural basis of the activity of some of these inhibitors, we also performed molecular docking studies to understand their interaction patterns and binding modes with HDAC2. We observed the low affinity compounds 4, 6 and 7 did not showed equal number of key π-π interactions and hydrogen bonding when compared to high affinity compounds, and could be the possible reason for poor inhibition as reflected in in vitro assays. These preliminary experimental and computational results will help to interpret the HDAC affinity values of these key compounds with caution.
Villar, Inmaculada C; Bubb, Kristen J; Moyes, Amie J; Steiness, Eva; Gulbrandsen, Trygve & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2016). Functional pharmacological characterization of SER100 in cardiovascular health and disease. British Journal of Pharmacology. ISSN 0007-1188. 173(23), s. 3386–3401. doi: 10.1111/bph.13634.
Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 477(1), s. 14–19. doi: 10.1016/j.bbrc.2016.05.138.
Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul & Levy, Finn Olav [Vis alle 9 forfattere av denne artikkelen] (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology. ISSN 0969-8051. 43(8), s. 478–489. doi: 10.1016/j.nucmedbio.2016.05.003.
Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 471(1), s. 219–225. doi: 10.1016/j.bbrc.2016.01.132.
Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf & Gauthier-Landry, louis [Vis alle 18 forfattere av denne artikkelen] (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism . OncoTarget. ISSN 1949-2553. 7(2), s. 1878–1894. doi: 10.18632/oncotarget.6479. Fulltekst i vitenarkiv Vis sammendrag
The underlying mechanisms responsible for the development of castration-resistant prostate cancer (CRPC) in patients who have undergone androgen deprivation therapy are not fully understood. This is the first study to address whether β2-adrenergic receptor (ADRB2)- mediated signaling may affect CRPC progression in vivo. By immunohistochemical analyses, we observed that low levels of ADRB2 is associated with a more rapid development of CRPC in a Norwegian patient cohort. To elucidate mechanisms by which ADRB2 may affect CRPC development, we stably transfected LNCaP cells with shRNAs to mimic low and high expression of ADRB2. Two UDP-glucuronosyltransferases, UGT2B15 and UGT2B17, involved in phase II metabolism of androgens, were strongly downregulated in two LNCaP shADRB2 cell lines. The low-ADRB2 LNCaP cell lines displayed lowered glucuronidation activities towards androgens than high-ADRB2 cells. Furthermore, increased levels of testosterone and enhanced androgen responsiveness were observed in LNCaP cells expressing low level of ADRB2. Interestingly, these cells grew faster than high-ADRB2 LNCaP cells, and sustained their low glucuronidation activity in castrated NOD/SCID mice. ADRB2 immunohistochemical staining intensity correlated with UGT2B15 staining intensity in independent TMA studies and with UGT2B17 in one TMA study. Similar to ADRB2, we show that low levels of UGT2B15 are associated with a more rapid CRPC progression. We propose a novel mechanism by which ADRB2 may affect the development of CRPC through downregulation of UGT2B15 and UGT2B17.
Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W. & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2015). Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. ACS Chemical Neuroscience. ISSN 1948-7193. 6(7), s. 1206–1218. doi: 10.1021/cn500339p.
Andressen, Kjetil Wessel; Manfra, Ornella; Brevik, Christian Hellesylt; Ulsund, Andrea Hembre; Vanhoenacker, Peter & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2015). The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. British Journal of Pharmacology. ISSN 0007-1188. 172(15), s. 3846–3860. doi: 10.1111/bph.13169.
Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 8 forfattere av denne artikkelen] (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0115547. Fulltekst i vitenarkiv
Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel & Krobert, Kurt Allen [Vis alle 9 forfattere av denne artikkelen] (2015). Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis. Frontiers in Behavioral Neuroscience. ISSN 1662-5153. 9(MAY). doi: 10.3389/fnbeh.2015.00092. Fulltekst i vitenarkiv
Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård & Andressen, Kjetil Wessel [Vis alle 10 forfattere av denne artikkelen] (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm. ISSN 2040-2503. 6, s. 708–714. doi: 10.1039/c4md00486h.
Ørstavik, Øivind; Ata, Salmana H; Riise, Jon; Dahl, Christen Peder; Andersen, Geir Øystein & Levy, Finn Olav [Vis alle 9 forfattere av denne artikkelen] (2014). Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart. British Journal of Pharmacology. ISSN 0007-1188. 171(23), s. 5169–5181. doi: 10.1111/bph.12647.
Melsom, Elin Maria Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2014). Gi proteins regulate adenylyl cyclase activity independent of receptor activation. PLoS Medicine. ISSN 1549-1277. 9:e0106608(9). doi: 10.1371/journal.pone.0106608. Fulltekst i vitenarkiv
Melsom, Elin Maria Caroline Bull; Hussain, Rizwan; Ørstavik, Øivind; Aronsen, Jan Magnus; Sjaastad, Ivar & Skomedal, Tor [Vis alle 9 forfattere av denne artikkelen] (2014). Non-classical regulation of β1- and β2 adrenoceptor- mediated inotropic responses in rat ventricle by the G protein Gi. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(12), s. 1177–1186. doi: 10.1007/s00210-014-1036-7.
Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman & Nilsen, Nils Olav [Vis alle 8 forfattere av denne artikkelen] (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(18), s. 4598–4602. doi: 10.1016/j.bmcl.2014.06.083.
Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(7), s. 1846–1850. doi: 10.1016/j.bmcl.2014.02.002.
Kilander, Michael Brita Christina; Petersen, Julian; Andressen, Kjetil Wessel; Ganji, Ranjani Sri; Levy, Finn Olav & Schuster, Jens [Vis alle 9 forfattere av denne artikkelen] (2014). Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. The FASEB Journal. ISSN 0892-6638. 28(5), s. 2293–2305. doi: 10.1096/fj.13-246363.
Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind & Lothe, Gustav B [Vis alle 11 forfattere av denne artikkelen] (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. doi: 10.1124/jpet.114.214882.
Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar & Skomedal, Tor [Vis alle 9 forfattere av denne artikkelen] (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(5), s. 407–417. doi: 10.1007/s00210-013-0953-1.
Bach, Trond; Bergholtz, Stine Louise; Riise, Jon; Qvigstad, Eirik; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 7 forfattere av denne artikkelen] (2014). Identification of small molecule NPR-B antagonists by high throughput screening - potential use in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(1), s. 5–14. doi: 10.1007/s00210-013-0940-6.
Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry. ISSN 0223-5234. 64, s. 629–637. doi: 10.1016/j.ejmech.2013.03.060.
Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 21(22), s. 7134–7145. doi: 10.1016/j.bmc.2013.09.004.
Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Krobert, Kurt Allen; Edvardsen, Thor & Moe, Ingvild Tronstad [Vis alle 13 forfattere av denne artikkelen] (2013). Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes. Molecular Pharmacology. ISSN 0026-895X. 84(3), s. 372–383. doi: 10.1124/mol.113.087312.
Levay, Magdolna; Krobert, Kurt Allen; Wittig, Karola; Voigt, Niels; Bermudez, Marcel & Wolber, Gerhard [Vis alle 9 forfattere av denne artikkelen] (2013). NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. 347(1), s. 69–79. doi: 10.1124/jpet.113.207266.
Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina & Ørstavik, Øivind [Vis alle 12 forfattere av denne artikkelen] (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology. ISSN 0007-1188. 170(2), s. 366–379. doi: 10.1111/bph.12282.
Gellynck, Evelien; Heyninck, Karen; Andressen, Kjetil Wessel; Haegeman, Guy; Levy, Finn Olav & Vanhoenacker, Peter [Vis alle 7 forfattere av denne artikkelen] (2013). The serotonin 5-HT7 receptors: two decades of research. Experimental Brain Research. ISSN 0014-4819. 230(4), s. 555–568. doi: 10.1007/s00221-013-3694-y.
Molenaar, Peter; Christ, Torsten; Hussain, Rizwan; Engel, Andreas; Berk, Emanuel & Gillette, Katherine T. [Vis alle 12 forfattere av denne artikkelen] (2013). PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients. British Journal of Pharmacology. ISSN 0007-1188. 169(3), s. 528–538. doi: 10.1111/bph.12167.
Hussain, Rizwan; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Osnes, Jan-Bjørn & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2013). The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 56, s. 129–138. doi: 10.1016/j.yjmcc.2012.11.015.
Riise, Jon; Nguyen, Hong Cam Thi; Hussain, Rizwan; Dahl, Christen Peder; Ege, Maren Stapnes & Osnes, Jan-Bjørn [Vis alle 10 forfattere av denne artikkelen] (2012). Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium. European Journal of Pharmacology. ISSN 0014-2999. 686(1-3), s. 66–73. doi: 10.1016/j.ejphar.2012.04.022.
Riise, Jon; Ørstavik, Øivind; Qvigstad, Eirik; Dahl, Christen Peder; Osnes, Jan-Bjørn & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2012). Prostaglandin E-1 facilitates inotropic effects of 5-HT4 serotonin receptors and beta-adrenoceptors in failing human heart. Basic Research in Cardiology. ISSN 0300-8428. 107(5). doi: 10.1007/s00395-012-0295-z.
Bilbija, Dusan; Haugen, Fred; Sagave, Julia Fritzi; Baysa, Anton; Bastani, Nasser Ezzatkhah & Levy, Finn Olav [Vis alle 9 forfattere av denne artikkelen] (2012). Retinoic Acid Signalling Is Activated in the Postischemic Heart and May Influence Remodelling. PLOS ONE. ISSN 1932-6203. 7(9). doi: 10.1371/journal.pone.0044740.
Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise & Birkeland, Jon Arne [Vis alle 10 forfattere av denne artikkelen] (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLOS ONE. ISSN 1932-6203. 7(9). doi: 10.1371/journal.pone.0045489. Fulltekst i vitenarkiv
Gellynck, Evelien; Andressen, Kjetil Wessel; Lintermans, Béatrice; Haegeman, Guy; Levy, Finn Olav & Vanhoenacker, Peter [Vis alle 7 forfattere av denne artikkelen] (2012). Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor. The FEBS Journal. ISSN 1742-464X. 279(11), s. 1994–2003. doi: 10.1111/j.1742-4658.2012.08581.x.
von Lueder, Thomas Gero; Gravning, Jørgen A.; How, Ole-Jakob; Vinge, Leif Erik; Ahmed, Muhammad Shakil & Krobert, Kurt Allen [Vis alle 11 forfattere av denne artikkelen] (2012). Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 303(1), s. H66–H74. doi: 10.1152/ajpheart.00724.2011.
Brattelid, Trond & Levy, Finn Olav (2011). Quantification of GPCR mRNA Using Real-Time RT-PCR. Methods in molecular biology. ISSN 1064-3745. 746(3), s. 165–193. doi: 10.1007/978-1-61779-126-0_9.
Berrade, Luis; Aisa, Bárbara; Ramirez, María; Galiano, Silvia; Guccione, Salvatore & Moltzau, Lise Roman [Vis alle 13 forfattere av denne artikkelen] (2011). Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action. Journal of Medicinal Chemistry. ISSN 0022-2623. 54(8), s. 3086–3090. doi: 10.1021/jm2000773.
Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 384(6), s. 543–553. doi: 10.1007/s00210-011-0670-6.
Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology. ISSN 0007-1188. 162(1), s. 54–71. doi: 10.1111/j.1476-5381.2010.00890.x.
Hussain, Rizwan; Afzal, Faraz; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar & Osnes, Jan-Bjørn [Vis alle 9 forfattere av denne artikkelen] (2011). Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. British Journal of Pharmacology. ISSN 0007-1188. 162(4), s. 908–916. doi: 10.1111/j.1476-5381.2010.01097.x.
Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 18(24), s. 8600–8613. doi: 10.1016/j.bmc.2010.10.011.
Brattelid, Trond; Winer, Lisbeth Hagen; Levy, Finn Olav; Liestøl, Knut; Sejersted, Ole M & Andersson, Kristin Brevik (2010). Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies. BMC Molecular Biology. ISSN 1471-2199. 11. doi: 10.1186/1471-2199-11-22.
Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina & Sjaastad, Ivar [Vis alle 9 forfattere av denne artikkelen] (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research (CVR). ISSN 0008-6363. 85(4), s. 763–772. doi: 10.1093/cvr/cvp364.
Hussain, RI; Qvigstad, Eirik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology. ISSN 0007-1188. 156(4), s. 575–586. doi: 10.1111/j.1476-5381.2009.00016.x.
Kjekshus, John; Torp-Pedersen, C; Gullestad, Lars; Kober, L; Edvardsen, Thor & Olsen, IC [Vis alle 11 forfattere av denne artikkelen] (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European Journal of Heart Failure. ISSN 1388-9842. 11(8), s. 771–778. doi: 10.1093/eurjhf/hfp087.
Hussain, Rizwan; Qvigstad, Erik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology. ISSN 0007-1188. 156(4), s. 575–586. doi: 10.1111/j.1750-3639.2009.00016.x. Vis sammendrag
Background and purpose: Muscarinic stimulation increases myofilament Ca2+ sensitivity with no apparent inotropic response in normal rat myocardium. Increased myofilament Ca2+ sensitivity is a molecular mechanism promoting increased contractility in failing cardiac tissue. Thus, muscarinic receptor activation could elicit inotropic responses in ventricular myocardium from rats with heart failure, through increasing phosphorylation of myosin light chain (MLC). Experimental approach: Contractile force was measured in left ventricular papillary muscles from male Wistar rats, 6 weeks after left coronary artery ligation or sham surgery. Muscles were also frozen, and MLC‐2 phosphorylation level was quantified. Key results: Carbachol (10 µmol·L−1) evoked a positive inotropic response only in muscles from rats with heart failure approximating 36% of that elicited by 1 µmol·L−1 isoproterenol (20 ± 1.5% and 56 ± 6.1% above basal respectively). Carbachol‐evoked inotropic responses did not correlate with infarction size but did correlate with increased left ventricular end diastolic pressure, heart weight/body weight ratio and lung weight, primary indicators of the severity of heart failure. Only muscarinic receptor antagonists selective for M2 receptors antagonized carbachol‐mediated inotropic effects with the expected potency. Carbachol‐evoked inotropic responses and increase in phosphorylated MLC‐2 were attenuated by MLC kinase (ML‐9) and Rho‐kinase inhibition (Y‐27632), and inotropic responses were abolished by Pertussis toxin pretreatment. Conclusion and implications: In failing ventricular muscle, muscarinic receptor activation, most likely via M2 receptors, provides inotropic support by increasing MLC phosphorylation and consequently, myofilament Ca2+ sensitivity. Enhancement of myofilament Ca2+ sensitivity, representing a less energy‐demanding mechanism of inotropic support may be particularly advantageous in failing hearts.
Eikemo, Hilde; Skomedal, Tor; Levy, Finn Olav & Osnes, Jan-Bjørn (2008). Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors. Analytical Biochemistry. ISSN 0003-2697. 383(2), s. 323–325. doi: 10.1016/j.ab.2008.09.011.
Kloster, Martine Müller; Hafte, Tolesa Tilahun; Moltzau, Lise Roman; Hallan, Elin; Dahle, Maria Krutå & Skålhegg, Bjørn Steen [Vis alle 10 forfattere av denne artikkelen] (2008). EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase. Cellular Signalling. ISSN 0898-6568. 20(6), s. 1169–1178. doi: 10.1016/j.cellsig.2008.02.007.
Ramberg, Håkon; Eide, Turid; Krobert, Kurt Allen; Levy, Finn Olav; Dizeyi, N & Bjartell, AS [Vis alle 8 forfattere av denne artikkelen] (2008). Hormonal regulation of beta(2)-adrenergic receptor level in prostate cancer. The Prostate. ISSN 0270-4137. 68(10), s. 1133–1142. doi: 10.1002/pros.20778.
Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin & Florholmen, Geir [Vis alle 11 forfattere av denne artikkelen] (2008). Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A. Cardiovascular Research (CVR). ISSN 0008-6363. 80(1), s. 47–54. doi: 10.1093/cvr/cvn180.
Riise, J; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Sandnes, Dagny Lise; Osnes, Jan-Bjørn & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2008). Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation. Cardiovascular Research (CVR). ISSN 0008-6363. 80(3), s. 407–415. doi: 10.1093/cvr/cvn216.
Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar & Dahl, Christen Peder [Vis alle 10 forfattere av denne artikkelen] (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology. ISSN 0007-1188. 155(7), s. 1005–1014. doi: 10.1038/bjp.2008.339.
Levy, Finn Olav; Qvigstad, Eirik; Krobert, Kurt Allen; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Effects of serotonin in failing cardiac ventricle: Signalling mechanisms and potential therapeutic implications. Neuropharmacology. ISSN 0028-3908. 55(6), s. 1066–1071. doi: 10.1016/j.neuropharm.2008.07.010.
Ngai, Jacob; Iversen, Trond Methi; Andressen, Kjetil Wessel; Levy, Finn Olav; Torgersen, Knut Martin & Vang, Torkel [Vis alle 8 forfattere av denne artikkelen] (2008). The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway. European Journal of Immunology. ISSN 0014-2980. 38(11), s. 3208–3218.
Gellynck, E; Laenen, K; Andressen, Kjetil Wessel; Lintermans, B; De Martelaere, K & Matthys, A [Vis alle 10 forfattere av denne artikkelen] (2008). Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain. Gene. ISSN 0378-1119. 426(1-2), s. 23–31. doi: 10.1016/j.gene.2008.08.011.

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Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 9 forfattere av denne artikkelen] (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology. ISSN 2050-6511. 16, s. A66–A66. doi: 10.1186/2050-6511-16-S1-A66.
Ytrehus, Kirsti; Larsen, Terje; Christensen, Geir Arve; Stensløkken, Kåre-Olav & Levy, Finn Olav (2015). In memory of Guro Valen (1960-2014). Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 79, s. 254–255. doi: 10.1016/j.yjmcc.2014.11.026.
Meier, Silja; Moltzau, Lise Roman; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 8 forfattere av denne artikkelen] (2014). Enhancement of B1 - adrenoceptor signaling by CNP through NPR-B and regulation by phosphodiesterases in normal and failing hearts.
Dugstad, K.; Ulsund, Andrea Hembre; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2014). Unraveling tight spatial regulation of 5-HT4 receptor-mediated inotropic effects using targeted FRET-based cAMP sensors.
Levy, Finn Olav (2013). Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 386(8), s. 665–670. doi: 10.1007/s00210-013-0874-z.
Dugstad, Kari Sandanger; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2012). Compartmented production and degradation of cAMP by beta-adrenergic, prostanoid and 5-HT4 receptors in CHF, visualized by FRET-based cAMP sensors.
Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 8 forfattere av denne artikkelen] (2012). NPR-A and NPR-B signal in different functional compartments in failing rat left ventricle. Cardiovascular Research (CVR). ISSN 0008-6363. 93, s. S18–S18. doi: 10.1093/cvr/cvr332.
Melsom, CB; Hussain, Rizwan; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2011). The role of inhibitory G protein upon beta-adrenoceptor-mediated signalling and inotropic responses in normal and failing rat heart left ventricle: Functional evidence of "tonic" Gi activation.
Meier, Silja; Aronsen, Jan Magnus; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 7 forfattere av denne artikkelen] (2011). Enhancement of B1-adrenoceptor signaling by C-type natriuretic peptide through natriuretic peptide receptor B in normal and failing hearts: regulation by phosphodiesterases.
Andressen, Kjetil Wessel; Dugstad, KS; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2011). Unraveling tight spatiotemporal regulation of cAMP-mediated inotropic effects using targeted FRET-based cAMP sensors.
Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2011). The negative inotropic and positive lusitropic responses to CNP are dependent on SERCA2 activity in failing rat ventricle.
Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2011). The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.
Meier, Silja; Levy, Finn Olav; Skomedal, Tor; Qvigstad, Eirik & Osnes, Jan-Bjørn (2010). Cardiac tissue hypothyroidism and receptor functions in heart failure.
Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Afzal, Faraz & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2010). Compartmentation of the cGMP signal causes differential functional responses after CNP and BNP stimulation in failing myocardium.
Qvigstad, Eirik; Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2010). The NO/cyclic GMP signalling pathway differentially affects 5-HT4 - and B1-AR mediated inotropic responses in failing ventricle.
Meier, Silja; Aronsen, Jan Magnus; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2010). C-type natriuretic peptide signalling through NPR-B enhances the B1-AR signalling both in non-failing and failing rat hearts.
Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin & Florholmen, Geir [Vis alle 10 forfattere av denne artikkelen] (2009). Mechanisms for cardiac dysfunction in COPD and respiratory failure. Respiratory Medicine. ISSN 0954-6111. 103, s. S6–S7.
Afzal, Faraz; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav & Skomedal, Tor [Vis alle 8 forfattere av denne artikkelen] (2009). Differential regulation of b2-adrenoceptor-mediated responses by PDE3 and PDE4 in failing and non-failing rat myocardium.
Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin & Florholmen, Geir [Vis alle 11 forfattere av denne artikkelen] (2009). Increased circulating IL-18; a possible mechanism for hypoxia-induced cardiac dysfunction.
Krobert, Kurt Allen; Hussain, Rizwan; Afzal, Faraz; Aronsen, Jon magnus; Sjaastad, Ivar & Osnes, Jan-Bjørn [Vis alle 8 forfattere av denne artikkelen] (2009). Inreased Gi activity does not contribute to the reduced beta-adrenergic inotropic effect in failing rat ventricle but Gi acts as a tonic brake on basal adenylyl cyclase activity.
Levy, Finn Olav (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricle. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, s. 131–131.
Levy, Finn Olav (2008). Antagonist-mediated down-regulation of 5-HT7 receptors by the atypical antipsychotics clozapine and olanzapine: evidence for functional selectivity. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, s. 60–60.
Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Sjaastad, Ivar; Afzal, Faraz & Skomedal, Tor [Vis alle 9 forfattere av denne artikkelen] (2008). Phospodiesterases regulating the negative inotropic response of C-type natriuretic peptide in heart failure. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, s. 17–17.
Levy, Finn Olav (2008). Regulation of the failing cardiac ventricle through 5-HT2A and 5-HT4 receptors: mechanisms and possible therapeutic consequences. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, s. 17–17.
Levy, Finn Olav (2008). Role of myocardial 5-HT4 and 5-HT2A receptors in heart failure. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, s. 112–112.
Eikemo, Hilde; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Evidence for an unidentified kinase activity phosphorylating myosin light chain-2 in quiescent cardiomyocytes. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 44, s. 782–782. doi: 10.1016/j.yjmcc.2008.02.170.
Afzal, Faraz & Levy, Finn Olav (2010). Phosphodiesterases and regulation of contractile function through β-adrenoceptors and 5-HT4 receptors in the failing heart. Unipub forlag.
Eikemo, Hilde; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2009). Regulation of myosin light chain 2 phosphorylation in cardiac muscle and its possible role in contractile responses. Universitetet i Oslo. ISSN 978-82-8072-348-2.
Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2009). Regulation of myosin light chain 2 phosphorylation in cardiac muscle and its possible role in contractile responses. Universitetet i Oslo.
Andressen, Kjetil Wessel & Levy, Finn Olav (2008). The 5-HT₇ serotonin receptor : G protein preassociation and functional selectivity. Unipub forlag. ISSN 978-82-8072-747-3.