The long-term collaboration between Department of Molecular Cell Biology (Iversen/Sandvig and collaborators) and Department of Tumor Biology (Mælandsmo group) has resulted in a new article published in International Journal of Nanomedicine (impact factor 8.0). Remya Valsalakumari is the first author and Tore-Geir Iversen the last and communicating author. The data show promising results following injection of cabazitaxel-loaded polyalkyl cyanoacrylate nanoparticles in mice bearing patient derived xenografts of triple negative breast cancer. The nanoparticles gave a strong effect both on the tumor and on the tumor-associated myeloid compartment, which probably boost the anti-tumor response. The study included contributions from scientists at SINTEF Trondheim, who manufactured the particles, and biologists in Newcastle and Salzburg. The particles used in this study were a further development of particles developed during Nanocan, a five-year national competence building project in nanomedicine (2013-2018) headed by Sandvig.
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