Karolina Spustova, postdoctoral researcher in Jorrit Enserink's group, has been awarded 6.6 million NOK from the Research Council of Norway. The project TiGeR will investigate how cells regulate selective autophagy.
UiO Podcast “Universitetspodden”: Podcast host Julie Nybakk Kvaal interviews Anne Simonsen.
Kristopher Schau meets Harald Stenmark for Podcast “Curious Norway” and news on Forskning.no
Cancer cells are highly dependent on their lysosomes, and damage of lysosome membranes has emerged as a novel strategy for cancer therapy. Maja Radulovic, project leader in Harald Stenmark´s group at CanCell, has previously identified mechanisms that mediate repair of damaged lysosome membranes, including a mechanism involving transfer of lipids from the endoplasmic reticulum (ER) to the damaged lysosome. However, it has remained unclear how efficient lipid transfer is orchestrated. In a recent paper in Nature Cell Biology, Radulovic and her co-workers have identified a new regulator of lysosome repair, the ER protein DFCP1. DFCP1 serves to concentrate lipid channels in ER microdomains that contact the damaged parts of the lysosome, thereby ensuring efficient membrane repair. Because DFCP1 microdomains are regulated by two druggable enzymes, this opens new possibilities for targeting lysosome integrity in cancer therapy.
Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy
CanCell postdoc Katharina Vestre in Tor Erik Rusten's group has written a popular science book about cells, released this week at Aschehoug forlag.
The professor is recognised for her groundbreaking work in autophagy and cancer, and for her central role in building a world-leading research environment at the University of Oslo. “I have always followed the paths where research has taken me,” the prize winner says.
Katarzyna (Kasia) Gajewska, a researcher in Marina Vietri’s CanCell project group, has been awarded a grant of 2 MNOK under the “radical ideas” programme of the Research Council of Norway. Her project is named “Under Pressure: Mechanosensitive Nuclear Bodies in Cancer Progression”
CanCell project leader Marina Vietri in Harald Stenmark’s group has received a grant from the South-Eastern Norway Regional Health Authority (Helse sør-øst) of 9 MNOK on the project “Uncovering hidden nuclear vulnerabilities: from mechanism to anticancer strategies".
Jeanne Corrales receives NFR innovation grant for development of novel antifungal drug agents.
Congratulations to Jorrit Enserink and Helene Knævelsrud
Professor Anne Simonsen has been awarded NOK 12 million in FRIPRO funding from the Research Council of Norway to investigate how the breakdown of mitochondria influences the development of cancer.
Funding supporting innovative studies in DNA damage and precision therapies for pediatric cancer
Postdoctoral fellow Samuel J. Rodgers at CanCell has received FRIPRO funding from the Research Council of Norway for cancer research. “The project we are embarking on may have implications for patients in the long term,” he says.
Project: “CancER-phagy: Unravelling and targeting ER-phagy in cancer” by Samuel Rodgers.
Project: “Cracking the Code of Cod Centromeres” by Nikolina Sekulic.
The researchers are studying the role of mitophagy in cancer development and how NK cells and antibodies can be utilised in cancer treatment.
Vi drysser millioner over toppforskere
https://kreftforeningen.no/aktuelt/vi-drysser-millioner-over-toppforskere/
Project: Development of drugs that overcome antifungal drug resistance by Jorrit Enserink, MN, Department of Biosciences.
Project: New anticancer drugs by Nikolina Sekulic, MED, Institute of Basic Medical Sciences.
Project leader Maja Radulovic and centre director Harald Stenmark at CanCell have recently published a review in Nature Reviews Molecular Cell Biology entitled “Lysosomal membrane homeostasis and its importance in physiology and disease”. The motivation for this review is that lysosomes play a central role in disease progression, including neurodegenerative diseases and cancer, but also offer opportunities for novel therapies
In the 25 June issue of Nature, Harald Stenmark and colleagues in Berkeley, Baltimore and Warsaw publish a review article on “The expanding repertoire of ESCRT functions in cell biology and disease”. The review discusses the functions of ESCRT proteins in diverse cellular functions and highlights the associations between ESCRT dysfunctions in neurodegenerative diseases and cancer.
Apsana Lamsal received 400 000 NOK in research funds from Lilly Constance og Karl Ingolf Larssons stiftelse, Congratulations!
SNX10 as a modulator of mitochondrial protein turnover and mitochondrial bioenergetics
Jorrit Enserink has been appointed to the A&D Board of The Organisation of European Cancer Institutes (OECI).
Alf Håkon Lystad, Jorrit Martijn Enserink, Jørgen Wesche and Viola Nähse received 3 MNOK in annual research funds for 3 years from HSØ for their cancer research projects. Congratulations!
Project leader Ellen Margrethe Haugsten and professor Philippe Collas received research funds from Rosa Sløyfe for their breast cancer research projects. Congratulations!
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