The endosomal sorting complex required for transport (ESCRT) machinery is a set of evolutionarily conserved protein complexes that promote the invagination and scission of cellular membranes. Since 2001, Stenmark´s group has contributed strongly to our understanding of how ESCRT proteins control cellular membrane dynamics processes such as endocytic downregulation of growth factor receptors and integrin molecules, nuclear and micronuclear envelope dynamics, autophagy, and repair of damaged lysosomes. Together with structural biologist James Hurley, UC Berkeley, neurobiologist Alyssa Coyne, Johns Hopkins University, Baltimore, and cancer cell biologist Marta Miaczynska, International Institute of Molecular and Cell Biology in Warsaw, Stenmark has reviewed these and other cellular processes controlled by ESCRT proteins, discussed their links to cancer and other diseases, and proposed new directions for how ESCRT dysfunctions can be targeted therapeutically.
https://www.nature.com/articles/s41586-025-08950-y