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HYBRIDA: Regulating Organoid Research

Embedding a comprehensive ethical dimension to organoid-based research and related technologies.

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HYBRIDA is a 3-year Science With and For Society (SwafS) project funded under HORIZON2020, coordinated by the University of Oslo, Norway.


The main objective is to develop a comprehensive regulatory framework for organoid research and organoid-related technologies.


The project aims to address how the conceptual, epistemological and regulatory uncertainties arise in organoid research, and to develop a conceptual and regulatory framework able to overcome the ‘persons vs things’ dualism.

From this follows also the need to communicate the potential and possible pitfalls of organoid research in ways that convey realistic- instead of hyped scenarios.


  • Identify Conceptual Uncertainty

    • Identify different forms of conceptual uncertainty by exploring the ontological, moral and legal status of organoids present in different cultures and knowledge traditions.
  • Reduce Epistemological Uncertainty

    • Reduce epistemological uncertainty in organoid research and produce improvements in impact assessment of organoid-related technologies.
  • Explore regulatory Uncertainty

    • Explore regulatory uncertainty prevalent in existing normative and ethical frameworks pertaining to technologies similar to organoid-related technologies.
  • Understand the General Public

    • Understand the worries, fears and expectations of the general public, vulnerable groups, patients, donors and civil society organisations with respect to organoids.
  • Engage stakeholders

    • Actively engage relevant stakeholders, in order to co-create and validate the 4 main products of HYBRIDA.
  • Produce Operational Guidelines

    • Produce a set of operational guidelines for the field of organoid research.
  • Produce Code of Responsible Conduct

    • Produce a Code of responsible conduct for organoid researchers and, if needed, suggest a supplement to the ECoC.
  • Enhance framework

    • Enhance existing ethics and normative frameworks with a focus on organoid research and organoid-related technologies.


    The consortium, further to the UiO, includes:

    • National Technical University of Athens (NTUA) – Greece
    • The University of Manchester (MAN) – United Kingdom
    • Universite Catholique de Louvain (UCL) – Belgium
    • Aarhus University (AU) – Denmark
    • Leiden University Medical Center (LUMC) –Netherlands
    • French National Institute for Health and Medical Research (INSERM) –France
    • Insubria University (UNINS) - Italy

      Project start and finish

      1 February 2021 – 31 January 2024

      Tags: Organoids, organoider
      Published May 6, 2021 2:06 PM - Last modified Aug. 8, 2022 2:39 PM


      Professor Søren Holm (Project leader)

      Main project page: