The Melum Group
The experimental liver research group is focusing on experimental and translational studies related to primary sclerosing cholangitis (PSC).
About the group
The group represents one of the three research groups at the Norwegian PSC research Centre. The main aim of our research is to understand mechanisms regulating cholangitis with a clear focus on immunology but also now incorporating aspects of regenerative medicine. In addition to the cholangitis focused studies, we are also doing basic research related to the function natural killer T-cells, mucosal associated invariant T (MAIT)-cells and other immune subsets. NKT and MAIT cells represents unconventional T-cells that are especially interesting in the context of liver diseases since they are abundantly present in the liver. The most important tools in our research are mouse models that reproduce aspects of cholangitis development. The ultimate goal of our research is to understand the pathology of and uncover potential novel treatment target for PSC.
In 2019, new lines of collaborations with Stefan Krauss and Hanne Scholz at the Centre of excellence Hybrid Technology Hub were started. We have in 2019 used our organoid technology from the bile ducts in pilot single sequencing projects which we will extend functionally in 2020. Currently, we are establishing methods related to single cell sequencing in our laboratory that can benefit the rest of the researchers at HTH.