The listed publication details a study involving a man with type 1 diabetes who received a transplant of donor islet cells without immunosuppressive therapy. The donor cells were genetically engineered to be hypoimmune, enabling them to evade destruction by the recipient’s immune system over the 12-week study period.
Link to Nature Medicine`s selection of Notable advances 2025: https://doi.org/10.1038/s41591-025-04098-4
Link to original publication in The New England Journal of Medicine:
https://doi.org/10.1056/NEJMoa2503822