Knut Tomas Dalen

• Lee, Yun K.; Sohn, Jee Hyung; Han, Ji Seul; Park, Yoon Jeong; Jeon, Yong Geun; Ji, Yul; Dalen, Knut Tomas; Sztalryd, Carole; Kimmel, Alan R. & Kim, Jae B. (2018). Perilipin 3 deficiency stimulates thermogenic Beige adipocytes through PPARa activation. Diabetes.  ISSN 0012-1797.  67(5), s 791- 804 . doi: 10.2337/db17-0983
• Yaddehi Gamage, Thilini Hansamali Gamage; Gunnes, Gjermund; Lee, Robert Hugh; Louch, William Edward; Holmgren, Asbjørn; Bruton, Joseph D.; Lengle, Emma; Kolstad, Terje R Selnes; Revold, Tobias; Amundsen, Silja Svanstrøm; Dalen, Knut Tomas; Holme, Pål Andre; Tjønnfjord, Geir Erland; Christensen, Geir Arve; Westerblad, Håkan; Klungland, Arne; Bergmeier, Wolfgang; Misceo, Doriana & Frengen, Eirik (2018). STIM1 R304W causes muscle degeneration and impaired platelet activation in mice. Cell Calcium.  ISSN 0143-4160.  76, s 87- 100 . doi: 10.1016/j.ceca.2018.10.001 Full text in Research Archive. Show summary

  STIM1 and ORAI1 regulate store-operated Ca2+ entry (SOCE) in most cell types, and mutations in these proteins have deleterious and diverse effects. We established a mouse line expressing the STIM1 R304 W gain-of-function mutation causing Stormorken syndrome to explore effects on organ and cell physiology. While STIM1 R304 W was lethal in the homozygous state, surviving mice presented with reduced growth, skeletal muscle degeneration, and reduced exercise endurance. Variable STIM1 expression levels between tissues directly impacted cellular SOCE capacity. In contrast to patients with Stormorken syndrome, STIM1 was downregulated in fibroblasts from Stim1R304W/R304W mice, which maintained SOCE despite constitutive protein activity. In studies using foetal liver chimeras, STIM1 protein was undetectable in homozygous megakaryocytes and platelets, resulting in impaired platelet activation and absent SOCE. These data indicate that downregulation of STIM1 R304 W effectively opposes the gain-of-function phenotype associated with this mutation, and highlight the importance of STIM1 in skeletal muscle development and integrity.

• Fan, Qiong; Nørgaard, Rikke Christine; Bindesbøll, Christian; Lucas, Christin; Dalen, Knut Tomas; Babaie, Eshrat; Itkonen, Harri; Matthews, Jason; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2017). LXR? regulates hepatic ChREBP? activity and lipogenesis upon glucose, but not fructose feeding in mice. Nutrients.  ISSN 2072-6643.  9(7) . doi: 10.3390/nu9070678
• Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin; Bakke, Siril Skaret; Kase, Eili Tranheim; Lee, Yun K; Kimmel, Alan R; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2017). Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research.  ISSN 0022-2275.  58(11), s 2147- 2161 . doi: 10.1194/jlr.M079764 Full text in Research Archive.
• Haj Yasein, Nadia; Berg, Ole; Jerneren, Fredrik; Refsum, Helga; Nebb, Hilde Irene & Dalen, Knut Tomas (2017). Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1862(6), s 623- 635 . doi: 10.1016/j.bbalip.2017.02.009
• Dahl, John Arne; Jung, Inkyung; Aanes, Håvard; Greggains, Gareth; Manaf, Adeel; Lerdrup, Mads; Li, Guoqiang; Kuan, Samantha; Li, Bin; Lee, Ah Young; Preissl, Sebastian; Jermstad, Ingunn; Haugen, Mads Haugland; Suganthan, Rajikala; Bjørås, Magnar; Hansen, Klaus; Dalen, Knut Tomas; Fedorcsák, Péter; Ren, Bing & Klungland, Arne (2016). Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature.  ISSN 0028-0836.  537(7621), s 548- 552 . doi: 10.1038/nature19360
• Drevinge, Christina; Dalen, Knut Tomas; Mannila, Maria Nastase; Täng, Margareta Scharin; Ståhlman, Marcus; Klevstig, Martina; Lundqvist, Annika; Mardani, Ismena; Haugen, Fred; Fogelstrand, Per; Adiels, Martin; Asin-Cayuela, Jorge; Ekestam, Charlotte; Gådin, Jesper R; Lee, Yun K; Nebb, Hilde Irene; Svedlund, Sara; Johansson, Bengt R; Hulten, Lillemor Mattsson; Romeo, Stefano; Redfors, Björn; Omerovic, Elmir; Levin, Max; Gan, Li; Eriksson, Per; Andersson, Linda; Ehrenborg, Ewa; Kimmel, Alan R; Boren, Jan & Levin, M (2016). Perilipin 5 is protective in the ischemic heart. International Journal of Cardiology.  ISSN 0167-5273.  219, s 446- 454 . doi: 10.1016/j.ijcard.2016.06.037
• Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit; Bindesbøll, Christian; Dalen, Knut Tomas; Birkeland, Kåre I.; Drevon, Christian A; Holen, Torgeir & Norheim, Frode (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports.  ISSN 2051-817X.  3:e12481(8), s 1- 15 . doi: 10.14814/phy2.12481
• Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Bindesbøll, Christian; Stadheim, Hans Kristian; Gulseth, Hanne Lovdal; Birkeland, Kåre I.; Kielland, Anders; Jensen, Jørgen; Dalen, Knut Tomas & Drevon, Christian A (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports.  ISSN 2051-817X.  2(8) . doi: 10.14814/phy2.12109
• Bindesbøll, Christian; Berg, Ole; Arntsen, Borghild M; Nebb, Hilde Irene & Dalen, Knut Tomas (2013). Fatty acids regulate perilipin5 in muscle by activating PPARdelta. Journal of Lipid Research.  ISSN 0022-2275.  54(7), s 1949- 1963 . doi: 10.1194/jlr.M038992
• Haj-Yasein, Nadia Nabil; Dalen, Knut Tomas; Berg, Ole; Bastani, Nasser Ezzatkhah; Refsum, Helga & Nebb, Hilde Irene (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. Journal of Inherited Metabolic Disease.  ISSN 0141-8955.  36, s S44 . doi: 10.1007/s10545-013-9631-1
• Telle, Vibeke Helen; Halvorsen, Bente; Dalen, Knut Tomas; Narverud, Ingunn; Rao, Nima; Granlund, L; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2013). Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype. Genes & Nutrition.  ISSN 1555-8932.  8(4), s 425- 434 . doi: 10.1007/s12263-012-0329-z
• Hsieh, Kai; Lee, Yen-Kun; Londos, C; Raaka, BM; Dalen, Knut Tomas & kimmel, Alan (2012). Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. Journal of Cell Science.  ISSN 0021-9533.  125(17), s 4067- 4076 . doi: 10.1242/jcs.104943
• Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild & Drevon, Christian A (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients.  ISSN 2072-6643.  4(12), s 1898- 1944 . doi: 10.3390/nu4121898 Show summary

  In spite of amazing progress in food supply and nutritional science, and a striking increase in life expectancy of approximately 2.5 months per year in many countries during the previous 150 years, modern nutritional research has a great potential of still contributing to improved health for future generations, granted that the revolutions in molecular and systems technologies are applied to nutritional questions. Descriptive and mechanistic studies using state of the art epidemiology, food intake registration, genomics with single nucleotide polymorphisms (SNPs) and epigenomics, transcriptomics, proteomics, metabolomics, advanced biostatistics, imaging, calorimetry, cell biology, challenge tests (meals, exercise, etc.), and integration of all data by systems biology, will provide insight on a much higher level than today in a field we may name molecular nutrition research. To take advantage of all the new technologies scientists should develop international collaboration and gather data in large open access databases like the suggested Nutritional Phenotype database (dbNP). This collaboration will promote standardization of procedures (SOP), and provide a possibility to use collected data in future research projects. The ultimate goals of future nutritional research are to understand the detailed mechanisms of action for how nutrients/foods interact with the body and thereby enhance health and treat diet-related diseases.

• Wang, H; Bell, H; Sreenevasan, u; Hu, H; Liu, J; Dalen, Knut Tomas; Londos, C; Yamaguchi, t; rizzo, ma; Coleman, r; Gong, d; Brasaemle, d & Sztalryd, C (2011). Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. Journal of Biological Chemistry.  ISSN 0021-9258.  286(6), s 15707- 15715
• Weedon, Mina Susanne; Dalen, Knut Tomas; Solaas, Karianne; Staff, Anne Cathrine; Duttaroy, Asim K. & Nebb, Hilde Irene (2010). Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. Journal of Lipid Research.  ISSN 0022-2275.  51(7), s 1886- 1896 . doi: 10.1194/jlr.M004978
• Qin, Yan; Dalen, Knut Tomas; Gustafsson, Jan Åke & Nebb, Hilde Irene (2009). Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1791(2), s 140- 147 . doi: 10.1016/j.bbalip.2008.12.003
• Wang, H; hu, l; Dalen, Knut Tomas; dorward, h; Marcinkiewicz, a; Russell, d; gond, d; Londos, C; Yamaguchi, t; holm, c; rizzo, ma; Brasaemle, d & Sztalryd, C (2009). Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. Journal of Biological Chemistry.  ISSN 0021-9258.  46(284), s 32116- 32125
• Dalen, Knut Tomas; Dahl, Tuva Børresdatter; Holter, Elin; Arntsen, Borghild M; Londos, C; Sztalryd, C & Nebb, Hilde Irene (2007). LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1771, s 210- 227 . doi: 10.1016/j.bbalip.2006.11.011
• Dalen, Knut Tomas; Ulven, Stine Marie; Arntsen, Borghild M; Solaas, Karianne & Nebb, Hilde Irene (2006). PPAR alpha activators and fasting induce the expression of adipose differentiation-related protein in liver. Journal of Lipid Research.  ISSN 0022-2275.  47, s 931- 943
• Tobin, Kari Anne Risan; Harsem, NK; Dalen, Knut Tomas; Staff, AC; Nebb, Hilde Irene & Duttaroy, Asim K. (2006). Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. Journal of Lipid Research.  ISSN 0022-2275.  47, s 815- 823
• Wang, Line M. Grønning; Tingsabadh, R; Hardy, K; Dalen, Knut Tomas; Jat, PS; Gnudi, L & Shepherd, P.R. (2006). Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  290(4), s 599- 606
• Zernichow, L; Dalen, Knut Tomas; Dalen, L.; Prydz, K; Winberg, Jan-Olof & Kolset, S O (2006). Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells. The FEBS Journal.  ISSN 1742-464X.  273
• Haugen, Fred; Zahid, N; Dalen, Knut Tomas; Hollung, K; Nebb, Hilde Irene & Drevon, Christian A (2005). Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid. Journal of Lipid Research.  ISSN 0022-2275.  46
• Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, JA & Nebb, Hilde Irene (2005). LXR is crucial in lipid metabolism. Prostaglandins, Leukotrienes and Essential Fatty Acids.  ISSN 0952-3278.  73, s 59- 63
• Dalen, Knut Tomas; Schoonjans, K; Ulven, SM; Weedon, Mina Susanne; Bentzen, Trine Gjesti; Koutnikova, H; Auwerx, J & Nebb, Hilde Irene (2004). Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes.  ISSN 0012-1797.  53(5), s 1243- 1252
• Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, Jan-Åke & Nebb, Hilde Irene (2004). Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue. Journal of Lipid Research.  ISSN 0022-2275.  45(11), s 2052- 2062
• Dalen, Knut Tomas; Ulven, Stine Marie & Nebb, Hilde Irene (2003). Expresssion of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. Journal of Biological Chemistry.  ISSN 0021-9258.  278(48), s 48283- 48291
• Juvet, Lene Kristine; Schuster, Gertrud U.; Dalen, Knut Tomas; Tobin, Kari Anne Risan; Hollung, Kristin; Haugen, Fred; Ulven, Stine Marie & Nebb, Hilde Irene (2003). On the role of liver X receptors in lipid accumulation in adipocytes. Molecular Endocrinology.  ISSN 0888-8809.  17, s 172- 182
• Alvik, Astrid & Dalen, Knut (2002). Det føtale alkoholsyndrom - FAS, I: Bente Gjærum & Bjørn Ellertsen (red.),  Hjerne og atferd; Utviklingsforstyrrelser hos barn og ungdom i et nevrobiologisk perspektiv.  Gyldendal Akademisk.  ISBN 82-05-30434-3.  i.  s 333 - 350
• Prydz, Kristian & Dalen, Knut Tomas (2000). Synthesis and sorting of proteoglycans. Journal of Cell Science.  ISSN 0021-9533.  113, s 193- 205

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• Dalen, Knut Tomas; londos, constantine & kimmel, Alan (2011). Adipocyte Fat Mobilization: The Regulatory Roles of Perilipin 1, Adipose Triglyceride Lipase, and Hormone Sensitive Lipase. Elsevier.  ISBN 978-0-12-443710-4.

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• Holven, Kirsten Bjørklund; Sæther, Thomas; Hjorth, Marit; Dalen, Knut Tomas; Ulven, Stine Marie; Ottestad, Inger & Hustad, Kristin Solheim (2019). Kan fisk utnyttes enda mer og samtidig fremme folkehelsen?. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  17(2), s 20- 22
• Løvik, Martinus; Dahl, Lisbeth; Mangschou, Bente; Ulven, Stine Marie; Andersen, Lene Frost; Dalen, Knut Tomas; Holvik, Kristin; Parr, Christine Louise; Stea, Tonje Holte & Strand, Tor A (2019). Assessment of dietary intake of fluoride and maximum limits of fluoride in food supplements. Opinion of the Panel on Nutrition, Dietetic Products, Novel Food and Allergy of the Norwegian Scientific Committee for Food and Environment. VKM Report. 2019:12. Full text in Research Archive.
• Andersson, Linda; Drevinge, Christina; Mardani, Ismena; Dalen, Knut Tomas; Ståhlman, Marcus; Klevstig, Martina; Lundqvist, Annika; Haugen, Fred; Adiels, Martin; Fogelstrand, Per; Asin-Cayuela, Jorge; Hultén, Lillemor Mattsson; Levin, Max; Ehrenborg, Ewa; Lee, Yun K.; Kimmel, Alan R.; Borén, Jan & Levin, Malin C. (2017). Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts. International Journal of Biochemistry and Cell Biology.  ISSN 1357-2725.  91, s 9- 13 . doi: 10.1016/j.biocel.2017.07.021
• Meadow, Richard; Asare, Nana Yaa Ohene; Dalen, Knut Tomas; Finne, Merethe Aasmo; Junttila, Olavi; Kirkendall, Lawrence R.; Måren, Inger Elisabeth; Yazdankhah, Siamak Pour; Dahl, Knut Helkås; Nielsen, Kaare Magne; Sanden, Monica; Vikse, Rose & Sorteberg, Hilde-Gunn Opsahl (2017). Risk assessment of insect-resistant and herbicide-tolerant genetically modified maize Bt11 for cultivation, import, processing, food and feed uses under Directive 2001/18/EC and Regulation (EC). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2017:22. Full text in Research Archive.
• Meadow, Richard; Asare, Nana Yaa Ohene; Finne, Merethe Aasmo; Junttila, Olavi; Kirkendall, Lawrence R.; Måren, Inger Elisabeth; Yazdankhah, Siamak Pour; Dahl, Knut Helkås; Dalen, Knut Tomas; Nielsen, Kaare Magne; Sanden, Monica; Vikse, Rose & Sorteberg, Hilde-Gunn Opsahl (2017). Risk assessment of insect-resistant and herbicide-tolerant genetically modified maize 1507 for cultivation, import, processing, food and feed uses under Directive 2001/18/EC (C/ES/01/01, C/NL/00/10) and Regulation (EC) No 1829/2003 (EFSA/GMO/NL/2004/02, EFSA/GMO/RX/1507). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2017:21. Full text in Research Archive.
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Junttila, Olavi; Mikalsen, Arne; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Dalen, Knut Tomas; Meadow, Richard; Måren, Inger Elisabeth; Nielsen, Kaare Magne; Sanden, Monica & Sorteberg, Hilde-Gunn Opsahl (2016). Final health and environmental risk assessment of genetically modified cotton 281-24-236 x 3006-210-23 (MXB-13). Scientific opinion on insect-resistant and glufosinate-tolerant, genetically modified MXB-13 from Dow AgroSciences for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2005/16). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2016:08. Full text in Research Archive.
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Junttila, Olavi; Mikalsen, Arne; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Meadow, Richard; Måren, Inger Elisabeth; Nielsen, Kaare Magne; Sanden, Monica & Sorteberg, Hilde-Gunn Opsahl (2016). Final health and environmental risk assessment of genetically modified LLcotton25. Scientific opinion on glufosinate-tolerant, genetically modified LLcotton25 from Bayer CropScience for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2005/13). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2016:10. Full text in Research Archive.
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Junttila, Olavi; Mikalsen, Arne; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Meadow, Richard; Måren, Inger Elisabeth; Nielsen, Kaare Magne; Sanden, Monica & Sorteberg, Hilde-Gunn Opsahl (2016). Final health and environmental risk assessment of genetically modified cotton GHB614. Scientific opinion on glyphosate-tolerant, genetically modified cotton GHB614 from Bayer CropScience for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2008/51). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2016:09. Full text in Research Archive.
• Andreassen, Åshild Kristine; Sipinen, Ville Erling; Finne, Merethe Aasmo; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Junttila, Olavi; Meadow, Richard; Måren, Inger Elisabeth; Nielsen, Kaare Magne; Sanden, Monica; Vikse, Rose & Sorteberg, Hilde-Gunn Opsahl (2016). Risk assessment of genetically modified carnation FLO-40685-2. Scientific opinion on genetically modified carnation FLO-40685-2 from Suntory Holdings Ltd. with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/13/02). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2016:35. Full text in Research Archive.
• Andreassen, Åshild Kristine; Sipinen, Ville Erling; Finne, Merethe Aasmo; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Junttila, Olavi; Meadow, Richard; Måren, Inger Elisabeth; Nielsen, Kaare Magne; Sanden, Monica; Vikse, Rose & Sorteberg, Hilde-Gunn Opsahl (2016). Risk assessment of genetically modified carnation SHD-27531-4. Scientific opinion on genetically modified carnation SHD-27531-4 from Suntory Holdings Ltd. with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/13/01). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2016:34. Full text in Research Archive.
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Nielsen, Kaare Magne; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Junttila, Olavi; Meadow, Richard & Sorteberg, Hilde-Gunn Opsahl (2015). Final health and environmental risk assessment of genetically modified soybean 356043. Scientific opinion on herbicide tolerant, genetically modified soybean 356043 from Pioneer Hi-Bred for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/UK/2007/43). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:13. Full text in Research Archive.
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Nielsen, Kaare Magne; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Junttila, Olavi; Meadow, Richard & Sorteberg, Hilde-Gunn Opsahl (2015). Final health and environmental risk assessment of genetically modified soybean MON 87701. Scientific opinion on insect resistant, genetically modified soybean MON 87701 from Monsanto for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/BE/2010/79). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:14. Full text in Research Archive.
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe; Junttila, Olavi; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Meadow, Richard; Nielsen, Kaare Magne; Sanden, Monica & Sorteberg, Hilde-Gunn Opsahl (2015). Final health and environmental risk assessment of genetically modified carnation Moonaqua 123.8.12. Scientific opinion on genetically modified carnation Moonaqua 123.8.12 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/06/01). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:16. Full text in Research Archive.
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe; Junttila, Olavi; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Meadow, Richard; Nielsen, Kaare Magne; Sanden, Monica & Sorteberg, Hilde-Gunn Opsahl (2015). Final health and environmental risk assessment of genetically modified carnation Moonberry IFD-25958-3. Scientific opinion on genetically modified carnation Moonberry IFD-25958-3 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL /09/01). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:17. Full text in Research Archive.
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe; Junttila, Olavi; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Meadow, Richard; Nielsen, Kaare Magne; Sanden, Monica & Sorteberg, Hilde-Gunn Opsahl (2015). Final health and environmental risk assessment of genetically modified carnation Moonlite 123.2.38. Scientific opinion on genetically modified carnation Moonlite 123.2.38 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/04/02). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 205:15. Full text in Research Archive.
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe; Junttila, Olavi; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Dahl, Knut Helkås; Dalen, Knut Tomas; Meadow, Richard; Nielsen, Kaare Magne; Sanden, Monica & Sorteberg, Hilde-Gunn Opsahl (2015). Final health and environmental risk assessment of genetically modified carnation Moonvelvet IFD-26407-2. Scientific opinion on genetically modified carnation Moonvelvet IFD-26407-2 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/09/02). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:18. Full text in Research Archive.
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Finne, Merethe Aasmo; Mikalsen, Arne; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Junttila, Olavi; Meadow, Richard; Nielsen, Kaare Magne & Sorteberg, Hilde-Gunn Opsahl (2015). Final health and environmental risk assessment of genetically modified soybean MON 89788. Scientific opinion on herbicide tolerant, genetically modified soybean MON 89788 from Monsanto Company for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2006/36). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:09. Full text in Research Archive.
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Finne, Merethe Aasmo; Mikalsen, Arne; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Junttila, Olavi; Meadow, Richard; Nielsen, Kaare Magne & Sorteberg, Hilde-Gunn Opsahl (2015). Food/feed and environmental risk assessment of herbicide tolerant genetically modified soybean A2704-12 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (EFSA/GMO/NL/2005/18). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:07. Full text in Research Archive.
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Finne, Merethe Aasmo; Mikalsen, Arne; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; Brandtzæg, Per; Junttila, Olavi; Meadow, Richard; Nielsen, Kaare Magne & Sorteberg, Hilde-Gunn Opsahl (2015). Food/feed and environmental risk assessment of herbicide tolerant genetically modified soybean A5547-127 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (EFSA/GMO/NL/2008/52). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. VKM Report. 2015:08. Full text in Research Archive.
• Catterall, Tara Cherie; Johnson, Inna; Khan, Shaista; Jermstad, Ingunn; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2015). The Norwegian Transgenic Centre.
• Feng, Yuan Zeng; knabenes, Irlin Knivsland; Bakke, Siril S.; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2015). Increased lipid oxidation and decreased lipid storage in myotubes lacking the lipid droplet binding protein perilipin2.
• Bindesbøll, Christian; Berg, Ole; Arntsen, Borghild M; Nebb, Hilde Irene & Dalen, Knut Tomas (2014). Fatty acids regulate perilipin5 in muscle by activating PPARdelta.
• Dalen, Knut Tomas (2014). Transgenic techniques provided by the Norwegian Transgenic Centre.
• Dalen, Knut Tomas; Haj-Yasein, Nadia Nabil; Berg, Ole; Refsum, Helga & Nebb, Hilde Irene (2014). Cysteine and adipocyte differentiation.
• Feng, Yuan Zeng; knabenes, Irlin Knivsland; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2014). Increased lipid oxidation and decreased lipid storage in myotubes lacking perilipin2.
• Khan, Shaista; Jermstad, Ingunn; Catterall, Tara Cherie; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2014). The Norwegian Transgenic Centre.
• Bindesbøll, Christian; Fan, Qiong; Sæther, Thomas; Dalen, Knut Tomas; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2013). Nuclear receptors as targets for treatment and prevention of metabolic diseases. Show summary

  Obesity, type 2 diabetes (T2D) and its associated comorbidity atherosclerosis are the leading cause of mortality in the Western world. A major consequence of obesity is insulin resistance, which is strongly associated with deposition of fat and uncontrolled glucose production in the liver, thereby contributing to the development of T2D. Peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs) are lipid-activated nuclear receptors (NRs) that through target gene activation regulate systemic glucose and lipid metabolism, control cholesterol transport, and modulate inflammation within the vascular wall. The NR Group at the Department of Nutrition, UoO studies the LXRs and PPARs in cross-talk with signaling pathways activated by lipids, insulin and glucose. We have recently shown that LXRalpha and LXRbeta are targets for glucose-hexosamine-derived OGlcNAc modification in liver and macrophages. Importantly, induction of LXRa O-GlcNAcylation by high carbohydrate feeding coincides with increased expression of the lipogenic gene SREBP-1c. This intriguing observation gives insight into novel aspects of LXR activation, and suggests LXR to be an important mediator of sugar-induced hepatic fat deposition and insulin resistance. Our ultimate goal is to gain new understanding of the role of LXRs and PPARs in the development of diet-induced metabolic diseases and to identify and develop specific ligands from marine microalgae for the treatment of metabolic disease.

• Telle-Hansen, Vibeke; Halvorsen, Bente; Dalen, Knut Tomas; Narverud, Ingunn; Wesseltoft-Rao, Nima; Granlund, Linda; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2013). Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype.
• Dalen, Knut Tomas (2011). Lipid droplet binding proteins and lipid accumulation.
• Dalen, Knut Tomas; Londos, C & Nebb, Hilde Irene (2009). PAT proteins and their function on intracellular lipid droplets.
• Dalen, Knut Tomas; Ulven, Stine Marie; Weedon, Mina Susanne; Bentzen, Trine Gjesti & Nebb, Hilde Irene (2004). The perioxisome proliferator-activated receptor gamma coordinately regulates the members of the lipid droplet associating protein gene family.
• Dalen, Knut Tomas; Ulven, Stine Marie & Nebb, Hilde Irene (2003). Insulin regulation of the insulin responsive glucose transporter (GLUT4) in adipocytes is dependent on Liver X receptor alpha.
• Dalen, Knut Tomas; Weedon, Mina Susanne; Bentzen, Trine Gjesti & Nebb, Hilde Irene (2002). The nuclear receptor PPARgamma regulates the expression of S3-12 and other members of the lipid droplet binding protein gene family in adipocytes.
• Prydz, Kristian; Vuong, Tram Thu; Dalen, Knut Tomas; Kulseth, M. A. & Kolset, Svein Olav (1997). Chondroitin sulfate glycosaminoglycan chains contain apical sorting information in epithelial MDCK cells.

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