Knut Tomas Dalen

• Hjorth, Marit; Doncheva, Atanaska Ivanova; Norheim, Frode Amador; Ulven, Stine Marie; Holven, Kirsten Bjørklund & Sæther, Thomas [Show all 7 contributors for this article] (2022). Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J mice. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-022-02930-y.
• Doncheva, Atanaska Ivanova; Romero, Silvana; Ramirez-Garrastacho, Manuel; Lee-Ødegård, Sindre; Kolnes, Kristoffer Jensen & Tangen, Daniel S. [Show all 11 contributors for this article] (2022). Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight. Acta Physiologica. ISSN 1748-1708. doi: 10.1111/apha.13862. Full text in Research Archive
• Torp, May-Kristin; Ranheim, Trine; Schjalm, Camilla; Hjorth, Marit; Heiestad, Christina Mathisen & Dalen, Knut Tomas [Show all 13 contributors for this article] (2022). Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis. Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.870811. Full text in Research Archive
• Hjorth, Marit; Galigniana, Natalia M.; Ween, Ola; Ulven, Stine Marie; Holven, Kirsten Bjørklund & Dalen, Knut Tomas [Show all 7 contributors for this article] (2022). Postprandial Effects of Salmon Fishmeal and Whey on Metabolic Markers in Serum and Gene Expression in Liver Cells. Nutrients. ISSN 2072-6643. 14(8). doi: 10.3390/nu14081593. Full text in Research Archive Show summary

  Fish is considered an important part of a healthy diet, in part due to the content of long chain omega-3 fatty acids. However, both lean and fatty fish have beneficial health effects, suggesting that micronutrients and proteins may play a role. In a randomised, controlled, cross-over trial, five healthy male participants consumed 5.2 g of protein from either salmon fishmeal or whey. Blood samples were taken before and 30 and 60 min after intake. The concentration of glucose, lipids, hormones and metabolites, including 28 different amino acids and derivatives, were measured in serum or plasma. Cultured HepG2 cells were incubated with or without serum from the participants, and transcriptomic profiling was performed using RNA sequencing. The ingestion of both salmon fishmeal and whey reduced the glucose and triglyceride levels in serum. Protein intake, independent of the source, increased the concentration of 22 amino acids and derivatives in serum. Fishmeal increased the concentration of arginine, methionine, serine, glycine, cystathionine and 2-aminobutyric acid more than whey did. Incubation with postprandial serum resulted in large transcriptomic alterations in serum-fasted HepG2 cells, with the differential expression of >4500 protein coding genes. However, when comparing cells cultivated in fasting serum to postprandial serum after the ingestion of fishmeal and whey, we did not detect any differentially regulated genes, neither with respect to the protein source nor with respect to the time after the meal. The comparable nutrigenomic effects of fishmeal and whey do not change the relevance of fish by-products as an alternative food source.

• Norheim, Frode Amador; Chella Krishnan, Karthickeyan; Bjellaas, Thomas; Vergnes, Laurent; Pan, Calvin & Parks, Brian W. [Show all 18 contributors for this article] (2021). Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Molecular Systems Biology. ISSN 1744-4292. 17. doi: 10.15252/msb.20209684. Full text in Research Archive
• Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik & Dalen, Knut Tomas [Show all 41 contributors for this article] (2021). Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment. VKM Report. ISSN 2535-4019. 2021(18). Full text in Research Archive Show summary

  The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This report considers whether the risk assessment guidance on genetically modified organisms, developed by the European Food Safety Authority (EFSA), can be applied to evaluate potential risks of organisms developed by genome editing. Background Gene technology has allowed for the transfer of genes between organisms and species, and thereby to design altered genotypes with novel traits, i.e. GMOs. A new paradigm started in the early 2000s with the development of genome-editing techniques. Unlike traditional genetic modification techniques resulting in insertion of foreign DNA fragments at random locations in the genome, the new genome-editing techniques additionally open for a few single nucleotide edits or short insertions/deletions at a targeted site in an organism’s genome. These new techniques can be applied to most types of organisms, including plants, animals and microorganisms of commercial interest. An important question is how the novel, genome-edited organisms should be evaluated with respect to risks to health and the environment. The European Court of Justice decided in 2018 to include genome-edited organisms in the GMO definition and hence in the regulatory system already in place. This implies that all products developed by genome-editing techniques must be risk-assessed within the existing regulatory framework for GMOs. The European and Norwegian regulatory frameworks regulate the production, import and placing on the market of food and feed containing, consisting of or produced from GMOs, as well as the release of GMOs into the environment. The assessment draws on guidance documents originally developed by EFSA for risk assessment of GMOs, which were drawn up mainly to address risks regarding insertion of transgenes. The new genome-editing techniques, however, provide a new continuum of organisms ranging from those only containing a minor genetic alteration to organisms containing insertion or deletion of larger genomic regions. Risk assessment of organisms developed by genome editing The present discourse on how new genome-editing techniques should be regulated lacks an analysis of whether risk assessment methodologies for GMOs are adequate for risk assessment of organisms developed through the use of the new genome-editing techniques. Therefore, this report describes the use of genome-editing techniques in food and feed production and discusses challenges in risk assessment with the regulatory framework. Specifically, this report poses the question as to whether the EFSA guidance documents are sufficient for evaluating risks to health and environment posed by genome-edited plants, animals and microorganisms. To address these questions, the report makes use of case examples relevant for Norway. These examples, intended for food and feed, include oilseed rape with a modified fatty acid profile, herbicide-tolerant and pest-resistant crops, sterile salmon, virus-resistant pigs and hornless cattle. The report considers all aspects of the stepwise approach as described in the EFSA guidance documents. Conclusions The inherent flexibility of the EFSA guidance makes it suitable to cover health and environmental risk assessments of a wide range of organisms with various traits and intended uses. Combined with the embedded case-by-case approach the guidance is applicable to genome-edited organisms. The evaluation of the guidance demonstrates that the parts of the health and environmental risk assessment concerned with novel traits (i.e. the phenotype of the organism) may be fully applied to all categories of genome-edited organisms. ............

• Hustad, Kristin Solheim; Ottestad, Inger Olaug; Hjorth, Marit; Dalen, Knut Tomas; Sæther, Thomas & Sheikh, Navida Akhter [Show all 9 contributors for this article] (2021). No effect of salmon fish protein on 2-h glucose in adults with increased risk of type 2 diabetes: a randomised controlled trial. British Journal of Nutrition. ISSN 0007-1145. 126(9), p. 1304–1313. doi: 10.1017/S0007114521000040. Full text in Research Archive
• Doncheva, Atanaska Ivanova; Norheim, Frode Amador; Hjorth, Marit; Grujic, Mirjana; Paivandy, Aida & Dankel, Simon N [Show all 14 contributors for this article] (2021). Serglycin Is Involved in Adipose Tissue Inflammation in Obesity. Journal of Immunology. ISSN 0022-1767. 208(1), p. 121–132. doi: 10.4049/jimmunol.2100231.
• Li, Yuchuan; Khanal, Prabhat; Norheim, Frode; Hjorth, Marit; Bjellaas, Thomas & Drevon, Christian A [Show all 9 contributors for this article] (2021). Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex. Journal of Lipid Research. ISSN 0022-2275. 62. doi: 10.1016/J.JLR.2021.100048. Full text in Research Archive
• Li, Yuchuan; Torp, May-Kristin; Norheim, Frode; Khanal, Prabhat; Kimmel, Alan R. & Stensløkken, Kåre-Olav [Show all 8 contributors for this article] (2020). Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1866(4). doi: 10.1016/j.bbalip.2020.158873. Full text in Research Archive Show summary

  Plin5 is abundantly expressed in the heart where it binds to lipid droplets (LDs) and facilitates physical interaction between LDs and mitochondria. We isolated cardiomyocytes from adult Plin5+/+ and Plin5-/- mice to study the role of Plin5 for fatty acid uptake, LD accumulation, fatty acid oxidation, and tolerance to hypoxia. Cardiomyocytes isolated from Plin5-/- mice cultured with oleic acid stored less LDs than Plin5+/+, but comparable levels to Plin5+/+ cardiomyocytes when adipose triglyceride lipase activity was inhibited. The ability to oxidize fatty acids into CO2 was similar between Plin5+/+ and Plin5-/- cardiomyocytes, but Plin5-/- cardiomyocytes had a transient increase in intracellular fatty acid oxidation intermediates. After pre-incubation with oleic acids, Plin5-/- cardiomyocytes retained a higher content of glycogen and showed improved tolerance to hypoxia compared to Plin5+/+. In isolated, perfused hearts, deletion of Plin5 had no important effect on ventricular pressures or infarct size after ischemia. Old Plin5-/- mice had reduced levels of cardiac triacylglycerides, increased heart weight, and apart from modest elevated expression of mRNAs for beta myosin heavy chain Myh7 and the fatty acid transporter Cd36, other genes involved in fatty acid oxidation, glycogen metabolism and glucose utilization were essentially unchanged by removal of Plin5. Plin5 seems to facilitate cardiac LD storage primarily by repressing adipose triglyceride lipase activity without altering cardiac fatty acid oxidation capacity. Expression of Plin5 and cardiac LD content of isolated cardiomyocytes has little importance for tolerance to acute hypoxia and ischemia, which contrasts the protective role for Plin5 in mouse models during myocardial ischemia.

• Henjum, Sigrun; Brantsæter, Anne Lise; Holvik, Kristin; Lillegaard, Inger Therese Laugsand; Mangschou, Bente & Parr, Christine Louise [Show all 14 contributors for this article] (2020). Benefit and risk assessment of iodization of household salt and salt used in bread and bakery products. Scientific opinion of the Panel on Nutrition, Dietetic Products, Novel Food and Allergy of the Norwegian Scientific Committee for Food and Environment. VKM Report. ISSN 2535-4019. 2020(5), p. 1–312. Full text in Research Archive
• Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B. & Farkas, Tamás [Show all 14 contributors for this article] (2019). The glutamine transporter Slc38a1 regulates GABAergic neurotransmission and synaptic plasticity. Cerebral Cortex. ISSN 1047-3211. 29(12), p. 5166–5179. doi: 10.1093/cercor/bhz055. Full text in Research Archive
• Mardani, Ismena; Dalen, Knut Tomas; Miljanovic, Azra; Drevinge, Christina; Ståhlman, Marcus & Klevstig, Martina [Show all 17 contributors for this article] (2019). Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-43335-y. Full text in Research Archive
• Yaddehi Gamage, Thilini Hansamali Gamage; Gunnes, Gjermund; Lee, Robert Hugh; Louch, William Edward; Holmgren, Asbjørn & Bruton, Joseph D. [Show all 19 contributors for this article] (2018). STIM1 R304W causes muscle degeneration and impaired platelet activation in mice. Cell Calcium. ISSN 0143-4160. 76, p. 87–100. doi: 10.1016/j.ceca.2018.10.001. Full text in Research Archive Show summary

  STIM1 and ORAI1 regulate store-operated Ca2+ entry (SOCE) in most cell types, and mutations in these proteins have deleterious and diverse effects. We established a mouse line expressing the STIM1 R304 W gain-of-function mutation causing Stormorken syndrome to explore effects on organ and cell physiology. While STIM1 R304 W was lethal in the homozygous state, surviving mice presented with reduced growth, skeletal muscle degeneration, and reduced exercise endurance. Variable STIM1 expression levels between tissues directly impacted cellular SOCE capacity. In contrast to patients with Stormorken syndrome, STIM1 was downregulated in fibroblasts from Stim1R304W/R304W mice, which maintained SOCE despite constitutive protein activity. In studies using foetal liver chimeras, STIM1 protein was undetectable in homozygous megakaryocytes and platelets, resulting in impaired platelet activation and absent SOCE. These data indicate that downregulation of STIM1 R304 W effectively opposes the gain-of-function phenotype associated with this mutation, and highlight the importance of STIM1 in skeletal muscle development and integrity.

• Lee, Yun K.; Sohn, Jee Hyung; Han, Ji Seul; Park, Yoon Jeong; Jeon, Yong Geun & Ji, Yul [Show all 10 contributors for this article] (2018). Perilipin 3 deficiency stimulates thermogenic Beige adipocytes through PPARa activation. Diabetes. ISSN 0012-1797. 67(5), p. 791–804. doi: 10.2337/db17-0983.
• Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin; Bakke, Siril Skaret & Kase, Eili Tranheim [Show all 11 contributors for this article] (2017). Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research. ISSN 0022-2275. 58(11), p. 2147–2161. doi: 10.1194/jlr.M079764. Full text in Research Archive
• Fan, Qiong; Nørgaard, Rikke Christine; Bindesbøll, Christian; Lucas, Christin; Dalen, Knut Tomas & Babaie, Eshrat [Show all 10 contributors for this article] (2017). LXR? regulates hepatic ChREBP? activity and lipogenesis upon glucose, but not fructose feeding in mice. Nutrients. ISSN 2072-6643. 9(7). doi: 10.3390/nu9070678.
• Haj Yasein, Nadia; Berg, Ole; Jerneren, Fredrik; Refsum, Helga; Nebb, Hilde Irene & Dalen, Knut Tomas (2017). Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1862(6), p. 623–635. doi: 10.1016/j.bbalip.2017.02.009.
• Drevinge, Christina; Dalen, Knut Tomas; Mannila, Maria Nastase; Täng, Margareta Scharin; Ståhlman, Marcus & Klevstig, Martina [Show all 30 contributors for this article] (2016). Perilipin 5 is protective in the ischemic heart. International Journal of Cardiology. ISSN 0167-5273. 219, p. 446–454. doi: 10.1016/j.ijcard.2016.06.037.
• Dahl, John Arne; Jung, Inkyung; Aanes, Håvard; Greggains, Gareth; Manaf, Adeel & Lerdrup, Mads [Show all 20 contributors for this article] (2016). Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. ISSN 0028-0836. 537(7621), p. 548–552. doi: 10.1038/nature19360.
• Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit & Bindesbøll, Christian [Show all 11 contributors for this article] (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports. ISSN 2051-817X. 3:e12481(8), p. 1–15. doi: 10.14814/phy2.12481.
• Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir & Bindesbøll, Christian [Show all 13 contributors for this article] (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports. ISSN 2051-817X. 2(8). doi: 10.14814/phy2.12109.
• Telle, Vibeke Helen; Halvorsen, Bente ; Dalen, Knut Tomas; Narverud, Ingunn; Rao, Nima & Granlund, L [Show all 8 contributors for this article] (2013). Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype. Genes & Nutrition. ISSN 1555-8932. 8(4), p. 425–434. doi: 10.1007/s12263-012-0329-z.
• Haj-Yasein, Nadia Nabil; Dalen, Knut Tomas; Berg, Ole; Bastani, Nasser Ezzatkhah; Refsum, Helga & Nebb, Hilde Irene (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. The Journal of Inherited Metabolic Disease (JIMD). ISSN 0141-8955. 36. doi: 10.1007/s10545-013-9631-1.
• Bindesbøll, Christian; Berg, Ole; Arntsen, Borghild M; Nebb, Hilde Irene & Dalen, Knut Tomas (2013). Fatty acids regulate perilipin5 in muscle by activating PPARdelta. Journal of Lipid Research. ISSN 0022-2275. 54(7), p. 1949–1963. doi: 10.1194/jlr.M038992.
• Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal & Holen, Torgeir [Show all 12 contributors for this article] (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients. ISSN 2072-6643. 4(12), p. 1898–1944. doi: 10.3390/nu4121898. Show summary

  In spite of amazing progress in food supply and nutritional science, and a striking increase in life expectancy of approximately 2.5 months per year in many countries during the previous 150 years, modern nutritional research has a great potential of still contributing to improved health for future generations, granted that the revolutions in molecular and systems technologies are applied to nutritional questions. Descriptive and mechanistic studies using state of the art epidemiology, food intake registration, genomics with single nucleotide polymorphisms (SNPs) and epigenomics, transcriptomics, proteomics, metabolomics, advanced biostatistics, imaging, calorimetry, cell biology, challenge tests (meals, exercise, etc.), and integration of all data by systems biology, will provide insight on a much higher level than today in a field we may name molecular nutrition research. To take advantage of all the new technologies scientists should develop international collaboration and gather data in large open access databases like the suggested Nutritional Phenotype database (dbNP). This collaboration will promote standardization of procedures (SOP), and provide a possibility to use collected data in future research projects. The ultimate goals of future nutritional research are to understand the detailed mechanisms of action for how nutrients/foods interact with the body and thereby enhance health and treat diet-related diseases.

• Hsieh, Kai; Lee, Yen-Kun; Londos, C; Raaka, BM; Dalen, Knut Tomas & kimmel, Alan (2012). Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. Journal of Cell Science. ISSN 0021-9533. 125(17), p. 4067–4076. doi: 10.1242/jcs.104943.
• Wang, H; Bell, H; Sreenevasan, u; Hu, H; Liu, J & Dalen, Knut Tomas [Show all 13 contributors for this article] (2011). Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. Journal of Biological Chemistry. ISSN 0021-9258. 286(6), p. 15707–15715.
• Weedon, Mina Susanne; Dalen, Knut Tomas; Solaas, Karianne; Staff, Anne Cathrine; Duttaroy, Asim K. & Nebb, Hilde Irene (2010). Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. Journal of Lipid Research. ISSN 0022-2275. 51(7), p. 1886–1896. doi: 10.1194/jlr.M004978.
• Qin, Yan; Dalen, Knut Tomas; Gustafsson, Jan Åke & Nebb, Hilde Irene (2009). Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1791(2), p. 140–147. doi: 10.1016/j.bbalip.2008.12.003.
• Wang, H; hu, l; Dalen, Knut Tomas; dorward, h; Marcinkiewicz, a & Russell, d [Show all 13 contributors for this article] (2009). Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. Journal of Biological Chemistry. ISSN 0021-9258. 46(284), p. 32116–32125.
• Dalen, Knut Tomas; Dahl, Tuva Børresdatter; Holter, Elin; Arntsen, Borghild M; Londos, C & Sztalryd, C [Show all 7 contributors for this article] (2007). LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1771, p. 210–227. doi: 10.1016/j.bbalip.2006.11.011.
• Zernichow, L; Dalen, Knut Tomas; Dalen, L.; Prydz, K; Winberg, Jan-Olof & Kolset, S O (2006). Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells. The FEBS Journal. ISSN 1742-464X. 273.
• Tobin, Kari Anne Risan; Harsem, NK; Dalen, Knut Tomas; Staff, AC; Nebb, Hilde Irene & Duttaroy, Asim K. (2006). Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. Journal of Lipid Research. ISSN 0022-2275. 47, p. 815–823.
• Dalen, Knut Tomas; Ulven, Stine Marie; Arntsen, Borghild M; Solaas, Karianne & Nebb, Hilde Irene (2006). PPAR alpha activators and fasting induce the expression of adipose differentiation-related protein in liver. Journal of Lipid Research. ISSN 0022-2275. 47, p. 931–943.
• Wang, Line M. Grønning; Tingsabadh, R; Hardy, K; Dalen, Knut Tomas; Jat, PS & Gnudi, L [Show all 7 contributors for this article] (2006). Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway. American Journal of Physiology. Endocrinology and Metabolism. ISSN 0193-1849. 290(4), p. 599–606.
• Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, JA & Nebb, Hilde Irene (2005). LXR is crucial in lipid metabolism. Prostaglandins, Leukotrienes and Essential Fatty Acids. ISSN 0952-3278. 73, p. 59–63.
• Haugen, Fred; Zahid, N; Dalen, Knut Tomas; Hollung, K; Nebb, Hilde Irene & Drevon, Christian A (2005). Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid. Journal of Lipid Research. ISSN 0022-2275. 46.
• Dalen, Knut Tomas; Schoonjans, K; Ulven, SM; Weedon, Mina Susanne; Bentzen, Trine Gjesti & Koutnikova, H [Show all 8 contributors for this article] (2004). Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes. ISSN 0012-1797. 53(5), p. 1243–1252.
• Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, Jan-Åke & Nebb, Hilde Irene (2004). Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue. Journal of Lipid Research. ISSN 0022-2275. 45(11), p. 2052–2062.
• Juvet, Lene Kristine; Schuster, Gertrud U.; Dalen, Knut Tomas; Tobin, Kari Anne Risan; Hollung, Kristin & Haugen, Fred [Show all 8 contributors for this article] (2003). On the role of liver X receptors in lipid accumulation in adipocytes. Molecular Endocrinology. ISSN 0888-8809. 17, p. 172–182.
• Dalen, Knut Tomas; Ulven, Stine Marie & Nebb, Hilde Irene (2003). Expresssion of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. Journal of Biological Chemistry. ISSN 0021-9258. 278(48), p. 48283–48291.
• Alvik, Astrid & Dalen, Knut (2002). Det føtale alkoholsyndrom - FAS. In Gjærum, Bente & Ellertsen, Bjørn (Ed.), Hjerne og atferd; Utviklingsforstyrrelser hos barn og ungdom i et nevrobiologisk perspektiv. Gyldendal Akademisk. ISSN 82-05-30434-3. p. 333–350.
• Prydz, Kristian & Dalen, Knut Tomas (2000). Synthesis and sorting of proteoglycans. Journal of Cell Science. ISSN 0021-9533. 113, p. 193–205.

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• Dalen, Knut Tomas; londos, constantine & kimmel, Alan (2011). Adipocyte Fat Mobilization: The Regulatory Roles of Perilipin 1, Adipose Triglyceride Lipase, and Hormone Sensitive Lipase. Elsevier. ISBN 978-0-12-443710-4.

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• Dalen, Knut Tomas (2021). Lipid droplets and transgenic animals.
• Holven, Kirsten Bjørklund; Sæther, Thomas; Hjorth, Marit; Dalen, Knut Tomas; Ulven, Stine Marie & Ottestad, Inger [Show all 7 contributors for this article] (2019). Kan fisk utnyttes enda mer og samtidig fremme folkehelsen? Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. 17(2), p. 20–22.
• Andersson, Linda; Drevinge, Christina; Mardani, Ismena; Dalen, Knut Tomas; Ståhlman, Marcus & Klevstig, Martina [Show all 18 contributors for this article] (2017). Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts. International Journal of Biochemistry and Cell Biology. ISSN 1357-2725. 91, p. 9–13. doi: 10.1016/j.biocel.2017.07.021.
• Feng, Yuan Zeng; knabenes, Irlin Knivsland; Bakke, Siril S.; Lund, Jenny; Lee, Y.K. & kimmel, Alan [Show all 9 contributors for this article] (2015). Increased lipid oxidation and decreased lipid storage in myotubes lacking the lipid droplet binding protein perilipin2.
• Catterall, Tara Cherie; Johnson, Inna; Khan, Shaista; Jermstad, Ingunn; Nesse, Gaute & Klungland, Arne [Show all 7 contributors for this article] (2015). The Norwegian Transgenic Centre.
• Bindesbøll, Christian; Berg, Ole; Arntsen, Borghild M; Nebb, Hilde Irene & Dalen, Knut Tomas (2014). Fatty acids regulate perilipin5 in muscle by activating PPARdelta.
• Dalen, Knut Tomas; Haj-Yasein, Nadia Nabil; Berg, Ole; Refsum, Helga & Nebb, Hilde Irene (2014). Cysteine and adipocyte differentiation.
• Dalen, Knut Tomas (2014). Transgenic techniques provided by the Norwegian Transgenic Centre.
• Khan, Shaista; Jermstad, Ingunn; Catterall, Tara Cherie; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2014). The Norwegian Transgenic Centre.
• Feng, Yuan Zeng; knabenes, Irlin Knivsland; Lund, Jenny; Lee, Y.K.; kimmel, Alan & Thoresen, G. Hege [Show all 8 contributors for this article] (2014). Increased lipid oxidation and decreased lipid storage in myotubes lacking perilipin2.
• Bindesbøll, Christian; Fan, Qiong; Sæther, Thomas; Dalen, Knut Tomas; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2013). Nuclear receptors as targets for treatment and prevention of metabolic diseases. Show summary

  Obesity, type 2 diabetes (T2D) and its associated comorbidity atherosclerosis are the leading cause of mortality in the Western world. A major consequence of obesity is insulin resistance, which is strongly associated with deposition of fat and uncontrolled glucose production in the liver, thereby contributing to the development of T2D. Peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs) are lipid-activated nuclear receptors (NRs) that through target gene activation regulate systemic glucose and lipid metabolism, control cholesterol transport, and modulate inflammation within the vascular wall. The NR Group at the Department of Nutrition, UoO studies the LXRs and PPARs in cross-talk with signaling pathways activated by lipids, insulin and glucose. We have recently shown that LXRalpha and LXRbeta are targets for glucose-hexosamine-derived OGlcNAc modification in liver and macrophages. Importantly, induction of LXRa O-GlcNAcylation by high carbohydrate feeding coincides with increased expression of the lipogenic gene SREBP-1c. This intriguing observation gives insight into novel aspects of LXR activation, and suggests LXR to be an important mediator of sugar-induced hepatic fat deposition and insulin resistance. Our ultimate goal is to gain new understanding of the role of LXRs and PPARs in the development of diet-induced metabolic diseases and to identify and develop specific ligands from marine microalgae for the treatment of metabolic disease.

• Telle-Hansen, Vibeke; Halvorsen, Bente ; Dalen, Knut Tomas; Narverud, Ingunn; Wesseltoft-Rao, Nima & Granlund, Linda [Show all 8 contributors for this article] (2013). Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype.
• Dalen, Knut Tomas (2011). Lipid droplet binding proteins and lipid accumulation.
• Dalen, Knut Tomas; Londos, C & Nebb, Hilde Irene (2009). PAT proteins and their function on intracellular lipid droplets.
• Dalen, Knut Tomas; Ulven, Stine Marie; Weedon, Mina Susanne; Bentzen, Trine Gjesti & Nebb, Hilde Irene (2004). The perioxisome proliferator-activated receptor gamma coordinately regulates the members of the lipid droplet associating protein gene family.
• Dalen, Knut Tomas; Ulven, Stine Marie & Nebb, Hilde Irene (2003). Insulin regulation of the insulin responsive glucose transporter (GLUT4) in adipocytes is dependent on Liver X receptor alpha.
• Dalen, Knut Tomas; Weedon, Mina Susanne; Bentzen, Trine Gjesti & Nebb, Hilde Irene (2002). The nuclear receptor PPARgamma regulates the expression of S3-12 and other members of the lipid droplet binding protein gene family in adipocytes.
• Prydz, Kristian; Vuong, Tram Thu; Dalen, Knut Tomas; Kulseth, M. A. & Kolset, Svein Olav (1997). Chondroitin sulfate glycosaminoglycan chains contain apical sorting information in epithelial MDCK cells.
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• Meadow, Richard; Asare, Nana Yaa Ohene; Dalen, Knut Tomas; Finne, Merethe Aasmo; Junttila, Olavi & Kirkendall, Lawrence R. [Show all 13 contributors for this article] (2017). Risk assessment of insect-resistant and herbicide-tolerant genetically modified maize Bt11 for cultivation, import, processing, food and feed uses under Directive 2001/18/EC and Regulation (EC). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-279-6. Full text in Research Archive
• Meadow, Richard; Asare, Nana Yaa Ohene; Finne, Merethe Aasmo; Junttila, Olavi; Kirkendall, Lawrence R. & Måren, Inger Elisabeth [Show all 13 contributors for this article] (2017). Risk assessment of insect-resistant and herbicide-tolerant genetically modified maize 1507 for cultivation, import, processing, food and feed uses under Directive 2001/18/EC (C/ES/01/01, C/NL/00/10) and Regulation (EC) No 1829/2003 (EFSA/GMO/NL/2004/02, EFSA/GMO/RX/1507). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-278-9. Full text in Research Archive
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Junttila, Olavi; Mikalsen, Arne & Sipinen, Ville Erling [Show all 14 contributors for this article] (2016). Final health and environmental risk assessment of genetically modified cotton 281-24-236 x 3006-210-23 (MXB-13). Scientific opinion on insect-resistant and glufosinate-tolerant, genetically modified MXB-13 from Dow AgroSciences for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2005/16). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-198-0. Full text in Research Archive
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Junttila, Olavi; Mikalsen, Arne; Sipinen, Ville Erling & Vikse, Rose [Show all 14 contributors for this article] (2016). Final health and environmental risk assessment of genetically modified cotton GHB614. Scientific opinion on glyphosate-tolerant, genetically modified cotton GHB614 from Bayer CropScience for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2008/51). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-199-7. Full text in Research Archive
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Junttila, Olavi; Mikalsen, Arne; Sipinen, Ville Erling & Vikse, Rose [Show all 14 contributors for this article] (2016). Final health and environmental risk assessment of genetically modified LLcotton25. Scientific opinion on glufosinate-tolerant, genetically modified LLcotton25 from Bayer CropScience for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2005/13). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-200-0. Full text in Research Archive
• Andreassen, Åshild Kristine; Sipinen, Ville Erling; Finne, Merethe Aasmo; Brandtzæg, Per; Dahl, Knut Helkås & Dalen, Knut Tomas [Show all 13 contributors for this article] (2016). Risk assessment of genetically modified carnation SHD-27531-4. Scientific opinion on genetically modified carnation SHD-27531-4 from Suntory Holdings Ltd. with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/13/01). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-224-6. Full text in Research Archive
• Andreassen, Åshild Kristine; Sipinen, Ville Erling; Finne, Merethe Aasmo; Brandtzæg, Per; Dahl, Knut Helkås & Dalen, Knut Tomas [Show all 13 contributors for this article] (2016). Risk assessment of genetically modified carnation FLO-40685-2. Scientific opinion on genetically modified carnation FLO-40685-2 from Suntory Holdings Ltd. with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/13/02). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-225-3. Full text in Research Archive
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Finne, Merethe Aasmo & Mikalsen, Arne [Show all 14 contributors for this article] (2015). Food/feed and environmental risk assessment of herbicide tolerant genetically modified soybean A2704-12 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (EFSA/GMO/NL/2005/18). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-162-1. Full text in Research Archive
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Finne, Merethe Aasmo & Mikalsen, Arne [Show all 14 contributors for this article] (2015). Food/feed and environmental risk assessment of herbicide tolerant genetically modified soybean A5547-127 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (EFSA/GMO/NL/2008/52). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-163-8. Full text in Research Archive
• Andreassen, Åshild Kristine; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas; Finne, Merethe Aasmo & Mikalsen, Arne [Show all 14 contributors for this article] (2015). Final health and environmental risk assessment of genetically modified soybean MON 89788. Scientific opinion on herbicide tolerant, genetically modified soybean MON 89788 from Monsanto Company for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/NL/2006/36). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety . Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-164-5. Full text in Research Archive
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas & Nielsen, Kaare Magne [Show all 13 contributors for this article] (2015). Final health and environmental risk assessment of genetically modified soybean 356043. Scientific opinion on herbicide tolerant, genetically modified soybean 356043 from Pioneer Hi-Bred for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/UK/2007/43). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-168-3. Full text in Research Archive
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Dahl, Knut Helkås; Dalen, Knut Tomas & Nielsen, Kaare Magne [Show all 13 contributors for this article] (2015). Final health and environmental risk assessment of genetically modified soybean MON 87701. Scientific opinion on insect resistant, genetically modified soybean MON 87701 from Monsanto for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (Application EFSA/GMO/BE/2010/79). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-169-0. Full text in Research Archive
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe & Junttila, Olavi [Show all 15 contributors for this article] (2015). Final health and environmental risk assessment of genetically modified carnation Moonlite 123.2.38. Scientific opinion on genetically modified carnation Moonlite 123.2.38 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/04/02). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegoan Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-170-6. Full text in Research Archive
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe & Junttila, Olavi [Show all 15 contributors for this article] (2015). Final health and environmental risk assessment of genetically modified carnation Moonaqua 123.8.12. Scientific opinion on genetically modified carnation Moonaqua 123.8.12 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/06/01). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-171-3. Full text in Research Archive
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe & Junttila, Olavi [Show all 15 contributors for this article] (2015). Final health and environmental risk assessment of genetically modified carnation Moonberry IFD-25958-3. Scientific opinion on genetically modified carnation Moonberry IFD-25958-3 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL /09/01). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-172-0. Full text in Research Archive
• Andreassen, Åshild Kristine; Asare, Nana Yaa Ohene; Bakke, Anne Marie; Finne, Merethe Aasmo; Jevnaker, Anne Marthe & Junttila, Olavi [Show all 15 contributors for this article] (2015). Final health and environmental risk assessment of genetically modified carnation Moonvelvet IFD-26407-2. Scientific opinion on genetically modified carnation Moonvelvet IFD-26407-2 from Florigene with modified petal colour for import as cut flowers for ornamental use under Part C of Directive 2001/18/EC (Application C/NL/09/02). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety. Norwegian Scientific Committee for Food Safety (VKM). ISSN 978-82-8259-173-7. Full text in Research Archive

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