Thomas Sæther

Associate Professor - Division of Biochemistry
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Phone +47 22851510
Room 2245
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Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1112 Blindern 0317 Oslo

Academic Interests

My research focus lies at the crossroad between transcription, gene regulation and nutrition. Currently, I am an Associate Professor in the Chromatin research group at the Dept. for Molecular Medicine, where we focus on chromatin regulation in adipose stem cells. We are also studying transcriptional complexes involved in the regulation of de novo lipogenesis in liver.

Teaching responsibilities

Social media

Higher education and employment history

  • Associate Professor in the Nuclear Receptor group at Dept. for Nutrition, UiO, from 2015-2018, studying regulation of hepatic de novo lipogenesis.
  • Postdoc in the Nuclear Receptor group at Dept. for Nutrition, UiO and Inst. for Medical biology at UiT, from 2012 to 2015, marine bioprospecting for novel PPAR agonists.
  • Postdoc in the MYB group at IMBV, UiO, from 2008 to 2012, focusing on the transcription factor c-Myb, eukaryotic gene regulation, transcription, chromatin, epigenetics, and post-translational modification, especially SUMOylation.
  • PhD in molecular biosciences, UiO, 2008: Positive and negative modulation of the transactivation potential of the transcription factor c-Myb - novel regulatory mechanisms for a classical proto-oncoprotein. Read more
  • MSc in biochemistry, UiO, 2003:  Metabolism of polyunsaturated fatty acids in rat testis. Read more

Honoraria

  • Throne Holst Foundation of Nutrition Research, Best poster 2016: Anti-diabetic activity from marine lipids: new anti-diabetic drug.
  • Nordic Association for Andrology’s Young Scientist Award, 2001: Effect of dietary fats, insulin and dexamethasone on delta-6-desaturase expression in rat testis.

Collaboration

  • Prof. Trond Vidar Hansen, Dept. of Pharmaceutical Chemistry , UiO: Chemical synthesis of PPAR-activating compounds.
  • Prof. Ingebrigt Sylte, Dept. of Medical Biology, UiT The Arctic University of Norway: 3D in silico docking of PPAR-agonists.
  • Senior Scientist Steinar Paulsen, MabCent - SFI, UiT The Arctic University of Norway: HTS for novel nuclear receptor ligands from marine invertebrates.
  • Prof. Hilde Nebb, prev. Dept. of Nutrition, UiO: Metabolic regulation and life style diseases. 
  • Prof. Dan Voytas, University of Minnesota: Design of zincfinger nucleases for targeted gene editing.
  • Prof. Tom Gonda, University of Queensland: Studies of the transforming potential of the transcription factor c-Myb.

Publications

Hjorth M, Doncheva A, Norheim F, Ulven SM, Holven KB, Sæther T, Dalen KT (2022). Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6J mice. Eur J Nutr, 61(8):4027-4043.

Hjorth M, Galigniana NM, Ween O, Ulven SM, Holven KB, Dalen KT, Sæther T (2022). Postprandial Effects of Salmon Fishmeal and Whey on Metabolic Markers in Serum and Gene Expression in Liver Cells. Nutrients, 14(8):1593.

Hustad KS, Ottestad I, Olsen T, Sæther T, Ulven SM, Holven KB (2022). Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomized controlled trial. Eur J Nutr, 61(6):3085-3093.

Stabell M, Sæther T, Røhr AK, Gabrielsen OS, Myklebost O (2021). Methylation-dependent SUMOylation of the architectural transcription factor HMGA2. Biochem Biophys Res Commun, 552:91-97.

Hustad KS, Ottestad I, Hjorth M, Dalen KT, Sæther T, Sheikh NA, Strømnes M, Ulven SM, Holven KB (2021). No effect of salmon fishmeal on 2h-glucose in adults with increased risk of 2 type 2 diabetes: a randomised controlled trial. Br J Nutr, 126:1304-13.

Fan Q, Nørgaard RC, Grytten I, Ness CM, Lucas C, Vekterud K, Soedling H, Matthews J, Lemma RB, Gabrielsen OS, Bindesbøll C, Ulven SM, Nebb HI, Grønning-Wang LM, Sæther T (2020). LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells, 9(5):1214.

Brunet A, Forsberg F, Fan Q, Sæther T, Collas P (2019). Nuclear Lamin B1 Interactions with Chromatin during the Circadian Cycle Are Uncoupled from Periodic Gene Expression. Front Genet 10:917.

Arnesen H, Haj-Yasein NN, Tungen JE, Soedling H, Matthews J, Paulsen SM, Nebb HI, Sylte I, Hansen TV, Sæther T (2019). Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorg Med Chem 27(18):4059-68.

Sæther T, Paulsen SM, Tungen JE, Vik A, Aursnes M, Holen T, Hansen TV, Nebb HI (2018). Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. Eur J Med Chem 155:736-753.

Fan Q, Moen A, Anonsen JH, Bindesbøll C, Sæther T, Carlson CR, Grønning-Wang LM (2018) O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase. Biochem Biophys Res Commun 499(2):354-360.

Moldes-Anaya, A, Sæther T, Uhlig S, Nebb HI, Larsen T, Eilertsen HC, Paulsen SM (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Mar Drugs 15(6):148.

Lorenzo PI, Brendeford EM, Gilfillan S, Gavrilov AA, Leedsak M, Razin SV, Eskeland R, Sæther T, Gabrielsen OS (2011) Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes Cancer 2(8):805-17.

Haugen TB, Tefre T, Malm G, Jönsson BA, Rylander L, Hagmar L, Bjørsvik C, Henrichsen T, Sæther T, Figenschau Y, Giwercman A (2011) Differences in serum levels of CB-153 and p,p'-DDE, and reproductive parameters between men living south and north in Norway. Reprod Toxicol 32(3):261-7.

Alm-Kristiansen AH, Lorenzo PI, Molværsmyr AK, Matre V, Ledsaak M, Sæther T, Gabrielsen OS (2011) PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Mol Cancer 10:21.

Sæther T, Pattabiraman DR, Alm-Kristiansen AH, Vogt-Kielland LT, Gonda TJ, Gabrielsen OS (2011) A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene 30(2):212-22.

Molværsmyr AK, Sæther T, Gilfillan S, Lorenzo PI, Kvaløy H, Matre V, Gabrielsen OS (2010) A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Res 38(15):4970-84.

Rylander L, Wetterstrand B, Haugen TB, Malm G, Malm J, Bjørsvik C, Henrichsen T, Sæther T, Giwercman A (2009) Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian J Androl 11(6):723-30.

Alm-Kristiansen AH, Sæther T, Matre V, Gilfillan S, Dahle O, Gabrielsen OS (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene 27(34):4644-56.

Berge T, Matre V, Brendeford EM, Sæther T, Lüscher B, Gabrielsen OS (2007) Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown. Blood Cells Mol Dis 39(3):278-86.

Ruhayel Y, Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Rylander L, Levine RJ, Giwercman A (2007) Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clin Endocrinol (Oxf). 67(1):85-92.

Sæther T, Berge T, Ledsaak M, Matre V, Alm-Kristiansen AH, Dahle O, Aubry F, Gabrielsen OS (2007) The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. J Biol Chem 282(19):13994-4005.

Sæther T, Tran TN, Rootwelt H, Grav HJ, Christophersen BO, Haugen TB (2007) Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction 133(2):467-77.

Aschim EL, Sæther T, Wiger R, Grotmol T, Haugen TB (2004). Differential distribution of splice variants of estrogen receptor beta in human testicular cells suggests specific functions in spermatogenesis. J Steroid Biochem Mol Biol 92(1-2):97-106.

Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Hagmar L, Rylander L, Levine RJ, Giwercman A (2004) Reproductive function during summer and winter in Norwegian men living north and south of the Arctic circle. J Clin Endocrinol Metab 89(9):4397-402.

Sæther T, Tran TN, Rootwelt H, Christophersen BO, Haugen TB (2003) Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Biol Reprod 69(1):117-24.

  • Hjorth, Marit; Doncheva, Atanaska Ivanova; Norheim, Frode Amador; Ulven, Stine Marie; Holven, Kirsten Bjørklund & Sæther, Thomas [Show all 7 contributors for this article] (2022). Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J mice. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-022-02930-y.
  • Hjorth, Marit; Galigniana, Natalia M.; Ween, Ola; Ulven, Stine Marie; Holven, Kirsten Bjørklund & Dalen, Knut Tomas [Show all 7 contributors for this article] (2022). Postprandial Effects of Salmon Fishmeal and Whey on Metabolic Markers in Serum and Gene Expression in Liver Cells. Nutrients. ISSN 2072-6643. 14(8). doi: 10.3390/nu14081593. Full text in Research Archive
  • Hustad, Kristin Solheim; Ottestad, Inger; Olsen, Thomas; Sæther, Thomas; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2022). Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial. European Journal of Nutrition. ISSN 1436-6207. 61(6), p. 3085–3093. doi: 10.1007/s00394-022-02857-4.
  • Hustad, Kristin Solheim; Ottestad, Inger Olaug; Hjorth, Marit; Dalen, Knut Tomas; Sæther, Thomas & Sheikh, Navida Akhter [Show all 9 contributors for this article] (2021). No effect of salmon fish protein on 2-h glucose in adults with increased risk of type 2 diabetes: a randomised controlled trial. British Journal of Nutrition. ISSN 0007-1145. 126(9), p. 1304–1313. doi: 10.1017/S0007114521000040. Full text in Research Archive
  • Stabell, Marianne; Sæther, Thomas; Kjendseth, Åsmund Røhr; Gabrielsen, Odd Stokke & Myklebost, Ola (2021). Methylation-dependent SUMOylation of the architectural transcription factor HMGA2. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 552, p. 91–97. doi: 10.1016/j.bbrc.2021.02.099. Full text in Research Archive
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2020). LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells. ISSN 2073-4409. 9(5), p. 1–26. doi: 10.3390/cells9051214. Full text in Research Archive
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2019). Open the LID: LXRα regulates ChREBPα transactivity in a target gene-specific manner through an agonist-modulated LBD-LID interaction. BioRxiv. ISSN 0362-4331. doi: 10.1101/2019.12.20.869974.
  • Brunet, Annaëlle; Forsberg, Anna Frida; Fan, Qiong; Sæther, Thomas & Collas, Philippe (2019). Nuclear lamin B1 interactions with chromatin during the circadian cycle are uncoupled from periodic gene expression. Frontiers in Genetics. ISSN 1664-8021. 10. doi: 10.3389/fgene.2019.00917. Full text in Research Archive
  • Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Södling, Helen; Matthews, Jason & Paulsen, Steinar M [Show all 10 contributors for this article] (2019). Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 27(18), p. 4059–4068. doi: 10.1016/j.bmc.2019.07.032. Full text in Research Archive
  • Sæther, Thomas; Paulsen, Steinar M; Tungen, Jørn Eivind; Vik, Anders; Aursnes, Marius & Holen, Torgeir [Show all 8 contributors for this article] (2018). Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. European Journal of Medicinal Chemistry. ISSN 0223-5234. 155, p. 736–753. doi: 10.1016/j.ejmech.2018.06.034. Full text in Research Archive
  • Fan, Qiong; Moen, Anders; Anonsen, Jan Haug; Bindesbøll, Christian; Sæther, Thomas & Carlson, Cathrine Rein [Show all 7 contributors for this article] (2018). O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 499(2), p. 354–360. doi: 10.1016/j.bbrc.2018.03.164.
  • Moldes-Anaya, Angel; Sæther, Thomas; Uhlig, Silvio; Nebb, Hilde Irene; Larsen, Terje & Eilertsen, Hans Christian [Show all 7 contributors for this article] (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Marine Drugs. ISSN 1660-3397. 15(148). doi: 10.3390/md15060148. Full text in Research Archive
  • Haugen, Trine B.; Tefre, Toril; Malm, Gunilla; Jønsson, Bo AG; Rylander, Lars & Hagmar, Lars [Show all 11 contributors for this article] (2011). Differences in serum levels of CB-153 and p,p '-DDE, and reproductive parameters between men living south and north in Norway. Reproductive Toxicology. ISSN 0890-6238. 32(3), p. 261–267. doi: 10.1016/j.reprotox.2011.06.072.
  • Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Molværsmyr, Ann-Kristin; Matre, Vilborg; Ledsaak, Marit & Sæther, Thomas [Show all 7 contributors for this article] (2011). PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Molecular Cancer. ISSN 1476-4598. 10. doi: 10.1186/1476-4598-10-21.
  • Sæther, Thomas; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege; Vogt- Kielland, Linn Troye; Gonda, T.J. & Gabrielsen, Odd Stokke (2011). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene. ISSN 0950-9232. 30(2), p. 212–222. doi: 10.1038/onc.2010.397.
  • Lorenzo, Petra Isabel O.; Brendeford, Elen Margrethe; Gilfillan, Siv ; Gavrilov, Alexey A; Ledsaak, Marit & Razin, Sergey V [Show all 9 contributors for this article] (2011). Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes & cancer. ISSN 1947-6019. 2(8), p. 805–817. doi: 10.1177/1947601911428224.
  • Molværsmyr, Ann-Kristin; Sæther, Thomas; Gilfillan, Siv ; Lorenzo, Petra Isabel O.; Kvaløy, Heidi & Matre, Vilborg [Show all 7 contributors for this article] (2010). A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Research (NAR). ISSN 0305-1048. 38(15), p. 4970–4984. doi: 10.1093/nar/gkq245.
  • Rylander, Lars; Wetterstrand, Boel; Haugen, Trine B.; Malm, Gunilla; Malm, Johan & Bjørsvik, Cathrine [Show all 9 contributors for this article] (2009). Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian Journal of Andrology (AJA). ISSN 1008-682X. 11(6), p. 723–730. doi: 10.1038/aja.2009.64.
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Matre, Vilborg; Otnæss, Siv Kolstø; Dahle, Øyvind & Gabrielsen, Odd Stokke (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene. ISSN 0950-9232. 27, p. 4644–4656. doi: 10.1038/onc.2008.105.
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine & Grotmol, Tom [Show all 12 contributors for this article] (2007). Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clinical Endocrinology. ISSN 0300-0664. 67. doi: 10.1111/j.1365-2265.2007.02843.x.
  • Sæther, Thomas; Tran, TN; Rootwelt, H; Grav, HJ; Christophersen, BO & Haugen, Trine B. (2007). Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction. ISSN 1470-1626. 133(2), p. 467–477. doi: 10.1530/REP-06-00294.
  • Sæther, Thomas; Berge, T; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege & Dahle, O [Show all 8 contributors for this article] (2007). The chromatin remodeling factor Mi-2 alpha acts as a novel co-activator for human c-Myb. Journal of Biological Chemistry. ISSN 0021-9258. 282. doi: 10.1074/jbc.M700755200.
  • Berge, Tone; Matre, Vilborg; Brendeford, Elen Margrethe; Sæther, Thomas; Lüscher, Bernhard & Gabrielsen, Odd Stokke (2007). Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitaion and c-Myb knockdown. Blood Cells, Molecules & Diseases. ISSN 1079-9796. 39(3), p. 278–286. doi: 10.1016/j.bcmd.2007.05.007.
  • Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom & Sæther, Thomas [Show all 12 contributors for this article] (2004). Reproductive function during summer and winter in Norwegian men living north and south of the Arctic Circle. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 89(9), p. 4397–4402. doi: 10.1210/jc.2004-0427.
  • Aschim, Elin L.; Sæther, Thomas; Wiger, Richard; Grotmol, Tom & Haugen, Trine B. (2004). Differential distribution of splice variants of estrogen receptor β in human testicular cells suggests specific functions in spermatogenesis. Journal of Steroid Biochemistry and Molecular Biology. ISSN 0960-0760. 92(1-2), p. 97–106. doi: 10.1016/j.jsbmb.2004.05.008.
  • Sæther, Thomas; Tran, Thien Ngoc; Rootwelt, Helge; Christophersen, Bjørn & Haugen, Trine Berit (2003). Expression and Regulation of delta 5-Desaturase, delta 6-Desaturase, Stearoyl-Coenzyme A (CoA) Desaturase 1, and Stearoyl-CoA Desaturase 2 in Rat Testis. Biology of Reproduction. ISSN 0006-3363. 69, p. 117–124. doi: 10.1095/biolreprod.102.014035.

View all works in Cristin

  • Sæther, Thomas (2021). Muliggjørende bioteknologi - hva vi kan gjøre med den, og hva den kan gjøre med oss .
  • Sæther, Thomas (2020). Ressursperson genetikk. In Movafagh, Hilde Marie Øgreid (Eds.), Hva er da et menneske ... . Norges Kristne Råd. ISSN 978-827941-035-5.
  • Heggøy, Oddvar; Shimmings, Paul; Nordsteien, Ola & Sæther, Thomas (2020). Magert med lappspurv i 2020. Vår Fuglefauna. ISSN 0332-5601. 43(4), p. 210–216.
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2019). LXRα interacts with the glucose-sensing transcription factor ChREBPα to regulate its transcriptional activity.
  • Sæther, Thomas; Ingvaldsen, Christoffer Aam & Lundby, Marit (2019). Denne fuglen er symbolet på det rike fuglelivet i Romerikes Amazonas. Nå er den i ferd med å forsvinne. [Newspaper]. Romerikes Blad.
  • Holven, Kirsten Bjørklund; Sæther, Thomas; Hjorth, Marit; Dalen, Knut Tomas; Ulven, Stine Marie & Ottestad, Inger [Show all 7 contributors for this article] (2019). Kan fisk utnyttes enda mer og samtidig fremme folkehelsen? Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. 17(2), p. 20–22.
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ulven, Stine Marie; Lucas, Christin & Bindesbøll, Christian [Show all 11 contributors for this article] (2018). LXRα interacts with the glucose-sensing transcription factor ChREBPα and increases its transcriptional activity.
  • Fan, Qiong; Nørgaard, Rikke Christine; Ulven, Stine Marie; Lucas, Christin; Bindesbøll, Christian & Grønning-Wang, Line Mariann [Show all 8 contributors for this article] (2018). Exploring the functional importance of a transcriptional cholesterol/sugar switch in liver.
  • Sæther, Thomas (2018). Digging into the ocean’s molecular treasure trove: Marine bioprospecting for anti-diabetic activities.
  • Nørgaard, Rikke Christine; Fan, Qiong; Lucas, Christin; Grønning-Wang, Line Mariann; Nebb, Hilde Irene & Sæther, Thomas (2017). LXRα interacts with the glucose-sensing transcription factor ChREBPα and increases its transcriptional activity.
  • Sæther, Thomas (2017). Havets hemmeligheter. [Internet]. UiOs Facebook-side.
  • Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar M & Sylte, Ingebrigt [Show all 8 contributors for this article] (2016). Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin & Sylte, Ingebrigt [Show all 8 contributors for this article] (2015). Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M & Nebb, Hilde Irene (2014). Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs).
  • Sæther, Thomas (2014). Anti-diabetic activity from marine lipids (ADAM): New anti-diabetic drugs.
  • Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M & Nebb, Hilde Irene (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Sæther, Thomas; Moldes-Anaya, Angel; Larsen, Laila Norrheim; Larsen, Terje; Paulsen, Steinar & Nebb, Hilde Irene (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2013). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets.
  • Bindesbøll, Christian; Fan, Qiong; Sæther, Thomas; Dalen, Knut Tomas; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2013). Nuclear receptors as targets for treatment and prevention of metabolic diseases.
  • Moldes-Anaya, Angel; Sæther, Thomas; Norrheim-Larsen, Laila; Nebb, Hilde Irene; Larsen, Terje & Paulsen, Steinar (2013). Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae.
  • Moldes-Anaya, Angel; Sæther, Thomas; Larsen, Laila Norrheim; Larsen, Terje; Nebb, Hilde Irene & Paulsen, Steinar (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Sæther, Thomas; Bengtsen, Mads; Molværsmyr, Ann-Kristin; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege & Ledsaak, Marit [Show all 8 contributors for this article] (2012). Regulating the regulator: SUMO functions as a master switch for the transcription factor c-Myb.
  • Molværsmyr, Ann-Kristin; Ledsaak, Marit; Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Matre, Vilborg & Sæther, Thomas [Show all 7 contributors for this article] (2012). The SUMO E3 ligase PIAS1 interacts with c-Myb and enhances its transcriptional activity.
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2012). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Gilfillan, Siv ; Alm-Kristiansen, Anne Hege; Aabel, Linn Ingeborg & Matre, Vilborg [Show all 7 contributors for this article] (2011). The hematopoietic transcription factor c-Myb functions as an epigenetic organizer.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Gilfillan, Siv ; Kvaløy, Heidi & Matre, Vilborg [Show all 7 contributors for this article] (2010). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch.
  • Rangberg, Anbjørg ; Sæther, Thomas & Gabrielsen, Odd Stokke (2010). Design of a system for inducible SUMOylation of the transcription factor c-Myb.
  • Sæther, Thomas; Pattabiraman, D.R.; Aabel, Linn Ingeborg; Matre, Vilborg; Gonda, T.J. & Gabrielsen, Odd Stokke (2010). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2009). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch.
  • Vollsund, Pernille; Bergholtz, Stine Louise; Sæther, Thomas; Aasland, Rein & Gabrielsen, Odd Stokke (2009). Understanding the phosphorylation-sumoylation cross talk in the transcription factor c-Myb.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Matre, Vilborg; Lorenzo, Petra Isabel O. & Gabrielsen, Odd Stokke (2008). SUMO-conjugation of the transcription factor c-Myb controls cooperative behaviour and induces an activator-to-repressor switch in the negative regulatory domain.
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege & Dahle, Øyvind [Show all 8 contributors for this article] (2007). The chromatin remodelling factor Mi-2alpha acts as a novel co-activator for human c-Myb.
  • Molværsmyr, Ann-Kristin; Kvaløy, Heidi; Sæther, Thomas; Matre, Vilborg & Gabrielsen, Odd Stokke (2007). Controlling gene expression through SUMO-conjugation - the importance of synergy.
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Ledsaak, Marit; Matre, Vilborg & Gabrielsen, Odd Stokke (2006). FLASH is a coregulator of the transcription factor c-Myb.
  • Sæther, Thomas; Tran, Thien N.; Rootwelt, Helge; Grav, Hans J.; Christophersen, Bjørn O. & Haugen, Trine B. (2006). Desaturase expression, lipid profile, and sperm morphology are differently affected by fat free diet in cauda and caput epididymis in the rat.
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Dahle, Øyvind; Matre, Vilborg & Lüscher, Bernhard [Show all 7 contributors for this article] (2004). Human c-Myb interacts with the Mi-2alpha subunit of the NuRD complex.
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine & Grotmol, Tom [Show all 13 contributors for this article] (2004). Seasonal Variation in Melatonin, Reproductive Hormones and Semen Parameters in Men living North and South of the Arctic Circle.
  • Sæther, Thomas; Christophersen, Bjørn O. & Haugen, Trine B. (2004). Essential fatty acid deficiency does not induce desaturases in testis, like in epididymis and liver.
  • Sæther, Thomas (2003). Lipid Dynamics And Sperm Function.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Malm, Gunilla; Haugen, Trine Berit; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom & Sæther, Thomas [Show all 10 contributors for this article] (2002). No Seasonal Variation in Sperm Parameters despite Extreme Differences in Daylight Conditions North of the Arctic Circle.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2001). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Tran, Thien Ngoc; Sæther, Thomas; Christophersen, Bjørn; Rootwelt, Helge; Retterstøl, Kjetil & Haugen, Trine Berit (2001). Expression of delta6- and delta5-desaturase in Rat Testis.
  • Sæther, Thomas; Aspelund, Trond; Eie, Knut; Hobøl, Erling; Ingvaldsen, Christoffer Aam & Starholm, Trude (2018). NØFs vannfugltellinger i Nordre Øyeren - kortrapport 2018 og regresjonsanalyser i forbindelse med flomtappingsprosjektet. Nordre Øyeren fuglestasjon.
  • Sæther, Thomas; Aspelund, Trond; Eie, Knut; Hobøl, Erling; Ingvaldsen, Christoffer Aam & Starholm, Trude (2018). Sluttrapport fra vaderregistreringer på Årnestangen 2015-2018. Nordre Øyeren fuglestasjon.
  • Sæther, Thomas & Erling, Hobøl (2010). Hekkefugltaksering på Fautøya og Rossholmens vesttange, Sesongrapport 2010. Nordre Øyeren fuglestasjon.
  • Kvebæk, Yngve; Sæther, Thomas; Aspelund, Trond & Hobøl, Erling (2009). NORDRE ØYEREN - Trend, trekkprofil og preferanseområde for viktige vannfuglarter - Komplett statusliste og øvrige artsvurderinger. Fylkesmannen i Oslo og Akershus.

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Published Feb. 10, 2014 2:03 PM - Last modified Oct. 28, 2022 12:22 PM