Knut Tomas Dalen

Associate Professor - Transgenic Animals and Lipid Storage
Image of Knut Tomas Dalen
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Phone +47 22851515
Mobile phone +47 91134097
Room L-162
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Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1046 Blindern 0317 Oslo

Academic interests

  • Molecular Nutrition
  • Lipid metabolism
  • Lipid droplet metabolism
  • Transcriptional regulation
  • Life style diseases such as metabolic syndrome, noninsulin-dependent diabetes mellitus (NIDDM/Type 2 Diabetes) and cardiovascular diseases

Teaching

  • ERN1010 (topics: Molecular Nutrition and Animal Research)
  • MED1100/ERN1100, Modul 1(topics: Nutrition and Gene Regulation)
  • ERN4210 (topic: Molecular Nutrition)
  • MF9490 (Laboratory Animal Handling)
  • MF9215 (topic: Transgenic Animals)
  • MF9110BTS (topic: Transgenic Animals)

Higher education and employment history

Education:

  • June 2005: Dr. Philos., (supervisor  Prof.Hilde Nebb), Department of Nutrition, University of Oslo.
  • 1997-1999: Candidatus Scientiarum in biochemistry, Department of Biosciences and Department of Nutrition, University of Oslo.
  • 1995-1996: Biochemistry - various courses. University of Oslo.
  • 1992-1995: Chemistry Engineer - specialized in Biotechnology, Østfold University College, Sarpsborg.

Employment:

  • 2009-2013: Post-doctoral research fellow (UoO, Refsum/Nebb), Department of Nutrition, University of Oslo.
  • 01-09.2009: Post-doctoral research fellow. (Chaudhry)The Biotechnology Centre of Oslo, University of Oslo.
  • 2007-2008: Researcher (UoO, Nebb), Department of Nutrition, University of Oslo.
  • 09.2005-08.2007: Visiting Fellow. (Pr. Constantine Londos lab), Membrane Regulation Section, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), US.
  • 2000-2005: Dr. philos/PhD Research Fellow (UoO, Nebb). Department of Nutrition, University of Oslo.
  • 01-06.2000: Research assistant. (Pr. Johan Auwerx). ”Institut de Génétique et de Biologie Molélulaire et Cellulaire (IGBMC)”, INSERM, Illkirch, France.
  • 1999-2000: Research assistant, (Nebb), Department of Nutrition, University of Oslo.

Honoraria

  • 2018: Throne Holst Foundation - manuscript award.
  • 2014: Throne Holst Foundation - manuscript award.
  • 2005: Intramural Visiting Fellow Award: NIDDK, NIH, Bethesda, US.
  • 2005: Research Travel Award: Henning och Johan Throne-Holst Foundation.
  • 2007: Research Travel Award: Henning och Johan Throne-Holst Foundation.

Collaboration

  • Prof. Alan Kimmel, NIDDK, National Institutes of Health, (NIH), US
  • Prof. Christian Drevon, Department of Nutrition, University of Oslo
  • Prof. Svein Olav Kolset, Department of Nutrition, University of Oslo
  • Prof. Hilde Nebb, Department of Nutrition, University of Oslo
  • Prof. Jan Boren, and Prof. Malin Levin, Sahlgranska Center for Cardiovascular and Metabolic Research (CMR), Goteborg, Sweden
  • Profs. Arild Rustan and Hege Thoresen, Dept. of Pharm. Biosciences, University of Oslo
Tags: Nutrition, Diabetes and hormones, Musculo-skeletal system, Lipids, Lipid droplets, Transcription, Nuclear receptors

Publications

  • Henjum, Sigrun; Brantsæter, Anne Lise; Holvik, Kristin; Lillegaard, Inger Therese Laugsand; Mangschou, Bente; Parr, Christine Louise; Starrfelt, Jostein; Stea, Tonje Holte; Andersen, Lene Frost; Dahl, Lisbeth Jane; Dalen, Knut Tomas; Løvik, Martinus; Ulven, Stine Marie & Strand, Tor A (2020). Benefit and risk assessment of iodization of household salt and salt used in bread and bakery products. Scientific opinion of the Panel on Nutrition, Dietetic Products, Novel Food and Allergy of the Norwegian Scientific Committee for Food and Environment. VKM Report.  ISSN 2535-4019.  2020(5), s 1- 312 Full text in Research Archive.
  • Li, Yuchuan; Torp, May-Kristin; Norheim, Frode; Khanal, Prabhat; Kimmel, Alan R.; Stensløkken, Kåre-Olav; Vaage, Ingvar Jarle & Dalen, Knut Tomas (2020). Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1866(4) . doi: 10.1016/j.bbalip.2020.158873 Show summary
  • Mardani, Ismena; Dalen, Knut Tomas; Miljanovic, Azra; Drevinge, Christina; Ståhlman, Marcus; Klevstig, Martina; Scharin Tang, Margareta; Fogelstrand, Per; Levin, Max; Ekstrand, Matias; Nair, Syam; Redfors, Björn; Omerovic, Elmir; Andersson, Linda; Kimmel, Alan R.; Boren, Jan & Levin, Malin C. (2019). Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart. Scientific Reports.  ISSN 2045-2322.  9(1) . doi: 10.1038/s41598-019-43335-y Full text in Research Archive.
  • Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B.; Farkas, Tamás; Dalen, Knut Tomas; Guo, Caiying; Hassel, Bjørnar; Utheim, Tor Paaske; Hvalby, Øyvind Christian; Hafting, Torkel; Harkany, Tibor; Fyhn, Marianne & Chaudhry, Farrukh Abbas (2019). The glutamine transporter Slc38a1 regulates GABAergic neurotransmission and synaptic plasticity. Cerebral Cortex.  ISSN 1047-3211.  29(12), s 5166- 5179 . doi: 10.1093/cercor/bhz055 Full text in Research Archive.
  • Lee, Yun K.; Sohn, Jee Hyung; Han, Ji Seul; Park, Yoon Jeong; Jeon, Yong Geun; Ji, Yul; Dalen, Knut Tomas; Sztalryd, Carole; Kimmel, Alan R. & Kim, Jae B. (2018). Perilipin 3 deficiency stimulates thermogenic Beige adipocytes through PPARa activation. Diabetes.  ISSN 0012-1797.  67(5), s 791- 804 . doi: 10.2337/db17-0983
  • Yaddehi Gamage, Thilini Hansamali Gamage; Gunnes, Gjermund; Lee, Robert Hugh; Louch, William Edward; Holmgren, Asbjørn; Bruton, Joseph D.; Lengle, Emma; Kolstad, Terje R Selnes; Revold, Tobias; Amundsen, Silja Svanstrøm; Dalen, Knut Tomas; Holme, Pål Andre; Tjønnfjord, Geir Erland; Christensen, Geir Arve; Westerblad, Håkan; Klungland, Arne; Bergmeier, Wolfgang; Misceo, Doriana & Frengen, Eirik (2018). STIM1 R304W causes muscle degeneration and impaired platelet activation in mice. Cell Calcium.  ISSN 0143-4160.  76, s 87- 100 . doi: 10.1016/j.ceca.2018.10.001 Full text in Research Archive. Show summary
  • Fan, Qiong; Nørgaard, Rikke Christine; Bindesbøll, Christian; Lucas, Christin; Dalen, Knut Tomas; Babaie, Eshrat; Itkonen, Harri; Matthews, Jason; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2017). LXR? regulates hepatic ChREBP? activity and lipogenesis upon glucose, but not fructose feeding in mice. Nutrients.  ISSN 2072-6643.  9(7) . doi: 10.3390/nu9070678
  • Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin; Bakke, Siril Skaret; Kase, Eili Tranheim; Lee, Yun K; Kimmel, Alan R; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2017). Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research.  ISSN 0022-2275.  58(11), s 2147- 2161 . doi: 10.1194/jlr.M079764 Full text in Research Archive.
  • Haj Yasein, Nadia; Berg, Ole; Jerneren, Fredrik; Refsum, Helga; Nebb, Hilde Irene & Dalen, Knut Tomas (2017). Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1862(6), s 623- 635 . doi: 10.1016/j.bbalip.2017.02.009
  • Dahl, John Arne; Jung, Inkyung; Aanes, Håvard; Greggains, Gareth; Manaf, Adeel; Lerdrup, Mads; Li, Guoqiang; Kuan, Samantha; Li, Bin; Lee, Ah Young; Preissl, Sebastian; Jermstad, Ingunn; Haugen, Mads Haugland; Suganthan, Rajikala; Bjørås, Magnar; Hansen, Klaus; Dalen, Knut Tomas; Fedorcsák, Péter; Ren, Bing & Klungland, Arne (2016). Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature.  ISSN 0028-0836.  537(7621), s 548- 552 . doi: 10.1038/nature19360
  • Drevinge, Christina; Dalen, Knut Tomas; Mannila, Maria Nastase; Täng, Margareta Scharin; Ståhlman, Marcus; Klevstig, Martina; Lundqvist, Annika; Mardani, Ismena; Haugen, Fred; Fogelstrand, Per; Adiels, Martin; Asin-Cayuela, Jorge; Ekestam, Charlotte; Gådin, Jesper R; Lee, Yun K; Nebb, Hilde Irene; Svedlund, Sara; Johansson, Bengt R; Hulten, Lillemor Mattsson; Romeo, Stefano; Redfors, Björn; Omerovic, Elmir; Levin, Max; Gan, Li; Eriksson, Per; Andersson, Linda; Ehrenborg, Ewa; Kimmel, Alan R; Boren, Jan & Levin, M (2016). Perilipin 5 is protective in the ischemic heart. International Journal of Cardiology.  ISSN 0167-5273.  219, s 446- 454 . doi: 10.1016/j.ijcard.2016.06.037
  • Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit; Bindesbøll, Christian; Dalen, Knut Tomas; Birkeland, Kåre I.; Drevon, Christian A; Holen, Torgeir & Norheim, Frode (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports.  ISSN 2051-817X.  3:e12481(8), s 1- 15 . doi: 10.14814/phy2.12481
  • Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Bindesbøll, Christian; Stadheim, Hans Kristian; Gulseth, Hanne Lovdal; Birkeland, Kåre I.; Kielland, Anders; Jensen, Jørgen; Dalen, Knut Tomas & Drevon, Christian A (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports.  ISSN 2051-817X.  2(8) . doi: 10.14814/phy2.12109
  • Bindesbøll, Christian; Berg, Ole; Arntsen, Borghild M; Nebb, Hilde Irene & Dalen, Knut Tomas (2013). Fatty acids regulate perilipin5 in muscle by activating PPARdelta. Journal of Lipid Research.  ISSN 0022-2275.  54(7), s 1949- 1963 . doi: 10.1194/jlr.M038992
  • Haj-Yasein, Nadia Nabil; Dalen, Knut Tomas; Berg, Ole; Bastani, Nasser Ezzatkhah; Refsum, Helga & Nebb, Hilde Irene (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. Journal of Inherited Metabolic Disease.  ISSN 0141-8955.  36, s S44 . doi: 10.1007/s10545-013-9631-1
  • Telle, Vibeke Helen; Halvorsen, Bente; Dalen, Knut Tomas; Narverud, Ingunn; Rao, Nima; Granlund, L; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2013). Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype. Genes & Nutrition.  ISSN 1555-8932.  8(4), s 425- 434 . doi: 10.1007/s12263-012-0329-z
  • Hsieh, Kai; Lee, Yen-Kun; Londos, C; Raaka, BM; Dalen, Knut Tomas & kimmel, Alan (2012). Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. Journal of Cell Science.  ISSN 0021-9533.  125(17), s 4067- 4076 . doi: 10.1242/jcs.104943
  • Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild & Drevon, Christian A (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients.  ISSN 2072-6643.  4(12), s 1898- 1944 . doi: 10.3390/nu4121898 Show summary
  • Wang, H; Bell, H; Sreenevasan, u; Hu, H; Liu, J; Dalen, Knut Tomas; Londos, C; Yamaguchi, t; rizzo, ma; Coleman, r; Gong, d; Brasaemle, d & Sztalryd, C (2011). Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. Journal of Biological Chemistry.  ISSN 0021-9258.  286(6), s 15707- 15715
  • Weedon, Mina Susanne; Dalen, Knut Tomas; Solaas, Karianne; Staff, Anne Cathrine; Duttaroy, Asim K. & Nebb, Hilde Irene (2010). Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. Journal of Lipid Research.  ISSN 0022-2275.  51(7), s 1886- 1896 . doi: 10.1194/jlr.M004978
  • Qin, Yan; Dalen, Knut Tomas; Gustafsson, Jan Åke & Nebb, Hilde Irene (2009). Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1791(2), s 140- 147 . doi: 10.1016/j.bbalip.2008.12.003
  • Wang, H; hu, l; Dalen, Knut Tomas; dorward, h; Marcinkiewicz, a; Russell, d; gond, d; Londos, C; Yamaguchi, t; holm, c; rizzo, ma; Brasaemle, d & Sztalryd, C (2009). Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. Journal of Biological Chemistry.  ISSN 0021-9258.  46(284), s 32116- 32125
  • Dalen, Knut Tomas; Dahl, Tuva Børresdatter; Holter, Elin; Arntsen, Borghild M; Londos, C; Sztalryd, C & Nebb, Hilde Irene (2007). LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1771, s 210- 227 . doi: 10.1016/j.bbalip.2006.11.011
  • Dalen, Knut Tomas; Ulven, Stine Marie; Arntsen, Borghild M; Solaas, Karianne & Nebb, Hilde Irene (2006). PPAR alpha activators and fasting induce the expression of adipose differentiation-related protein in liver. Journal of Lipid Research.  ISSN 0022-2275.  47, s 931- 943
  • Tobin, Kari Anne Risan; Harsem, NK; Dalen, Knut Tomas; Staff, AC; Nebb, Hilde Irene & Duttaroy, Asim K. (2006). Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. Journal of Lipid Research.  ISSN 0022-2275.  47, s 815- 823
  • Wang, Line M. Grønning; Tingsabadh, R; Hardy, K; Dalen, Knut Tomas; Jat, PS; Gnudi, L & Shepherd, P.R. (2006). Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  290(4), s 599- 606
  • Zernichow, L; Dalen, Knut Tomas; Dalen, L.; Prydz, K; Winberg, Jan-Olof & Kolset, S O (2006). Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells. The FEBS Journal.  ISSN 1742-464X.  273
  • Haugen, Fred; Zahid, N; Dalen, Knut Tomas; Hollung, K; Nebb, Hilde Irene & Drevon, Christian A (2005). Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid. Journal of Lipid Research.  ISSN 0022-2275.  46
  • Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, JA & Nebb, Hilde Irene (2005). LXR is crucial in lipid metabolism. Prostaglandins, Leukotrienes and Essential Fatty Acids.  ISSN 0952-3278.  73, s 59- 63
  • Dalen, Knut Tomas; Schoonjans, K; Ulven, SM; Weedon, Mina Susanne; Bentzen, Trine Gjesti; Koutnikova, H; Auwerx, J & Nebb, Hilde Irene (2004). Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes.  ISSN 0012-1797.  53(5), s 1243- 1252
  • Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, Jan-Åke & Nebb, Hilde Irene (2004). Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue. Journal of Lipid Research.  ISSN 0022-2275.  45(11), s 2052- 2062
  • Dalen, Knut Tomas; Ulven, Stine Marie & Nebb, Hilde Irene (2003). Expresssion of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. Journal of Biological Chemistry.  ISSN 0021-9258.  278(48), s 48283- 48291
  • Juvet, Lene Kristine; Schuster, Gertrud U.; Dalen, Knut Tomas; Tobin, Kari Anne Risan; Hollung, Kristin; Haugen, Fred; Ulven, Stine Marie & Nebb, Hilde Irene (2003). On the role of liver X receptors in lipid accumulation in adipocytes. Molecular Endocrinology.  ISSN 0888-8809.  17, s 172- 182
  • Alvik, Astrid & Dalen, Knut (2002). Det føtale alkoholsyndrom - FAS, I: Bente Gjærum & Bjørn Ellertsen (red.),  Hjerne og atferd; Utviklingsforstyrrelser hos barn og ungdom i et nevrobiologisk perspektiv.  Gyldendal Akademisk.  ISBN 82-05-30434-3.  i.  s 333 - 350
  • Prydz, Kristian & Dalen, Knut Tomas (2000). Synthesis and sorting of proteoglycans. Journal of Cell Science.  ISSN 0021-9533.  113, s 193- 205

View all works in Cristin

  • Dalen, Knut Tomas; londos, constantine & kimmel, Alan (2011). Adipocyte Fat Mobilization: The Regulatory Roles of Perilipin 1, Adipose Triglyceride Lipase, and Hormone Sensitive Lipase. Elsevier.  ISBN 978-0-12-443710-4.

View all works in Cristin

View all works in Cristin

Published Apr. 13, 2011 2:40 PM - Last modified Jan. 29, 2019 3:17 PM