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Experimental cardiology

The laboratory for experimental cardiology aims to identify molecular mechanisms that regulates short term and long term cardiac function. The goal is to develop future treatment for cardiac disease by detailed understanding of how signal molecules controls ion transporters and gene regulatory proteins.

Schematic figure depicting main strategies for treating cardiac illnesses

The figure shows the main research focus of the research group, and the strategy for developing future therapies for cardiac disease. The left figure shows how ion transporters and channels in concert is the physiological basis for the heart beat, and imbalance in these contributes to cardiac arrhythmias. The group aims to develop activators and the SR Ca2+ ATPase 2 (SERCA2) and the Na+/K+-ATPase (NKA) as future therapy for cardiac arrhythmias. The group further aims to develop agents that are able to switch on or off specific gene programs as future treatment for cardiac disease by controlling specific transcription factors and/or epigenetic modulators.

Group photo
Left to righjt: Mira Børstad, Jan Magnus Aronsen, Ingrid Albert, Jonas Skogestad, Gustav Lothe

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Published July 2, 2019 9:33 AM - Last modified Jan. 2, 2020 3:24 PM

Contact

Dept. of Molecular Medicine
Domus Medica
Gaustad
Sognsvannsveien 9
0372 Oslo

Group leader

Jan Magnus Aronsen