News

Published May 21, 2019 2:54 PM

In vivo electrophysiology and optogenetics on a project entitled ‘Integration of social and spatial information in the hippocampal formation’.

Published Jan. 23, 2018 2:19 PM

Neurons’ sugar coating is essential for long-term memories

How the brain is able to store memories over long periods of time has been a persistent mystery to neuroscientists. In a new study, researchers from the Centre for Integrative Neuroplasticity (CINPLA) at the University of Oslo show that long-lived extracellular matrix molecules called perineuronal nets are essential for distant memories.

The new research published in Proceedings of the National Academy of Sciences, shows that removal of the nets disrupts distant but not recent memories. 

http://www.pnas.org/content/early/2017/12/21/1713530115

Published Jan. 6, 2017 2:28 PM

Emerging evidence suggests a role for perineuronal nets (PNNs) in learning and regulation of plasticity but the underlying mechanisms remain unresolved. Here, we used chronic in vivo extracellular recordings to investigate how removal of PNNs affects plasticity and neural activity over time.