Cardiovascular Risk Reduction-Diet in Pregnancy
Follow-up study after two decades of mother-offspring pairs of the “Cardiovascular Risk Reduction-Diet in Pregnancy” (CARRDIP) randomized trial
About the project
Cardiovascular disease (CVD) is a major global cause of morbidity and mortality. Inadequate maternal diet during pregnancy can impair offspring health, and in particular increase the risk of CVD later in life. As CVD risk factors, such as cholesterol levels, track from childhood into adulthood, our main aim of the present study is to assess long-term risk factors for CVD among mothers and their offspring 20 years after they participated in the randomized controlled CARRDIP trial that determined CVD risk factors of a maternal anti-atherogenic diet in pregnancy. Our hypothesis is that this diet has led to decreased CVD risk among the mothers and offspring 20 years later.
Specifically we want to examine possible differences between the CARRDIP intervention and control mother-offspring pairs regarding:
- Dietary-modulated CVD risk markers
- Blood pressure, and in particular possible associations between placental blood flow 20 years ago and current offspring blood pressure
- Body composition and cardiovascular health