Arbeidsområde
MicroPET scanning: PET scanning of small rodents.
MicroPET service is currently not available for booking.
Slidescanning: scanning of bright field or fluorescence slides using Axio scanner from Zeiss.
You will find more information about the scanning service at our Norbrain slidescanning webpages at UiO.
Publikasjoner
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Alvestad, Silje; Hammer, Janniche; Qu, Hong; Håberg, Asta; Ottersen, Ole Petter & Sonnewald, Ursula
(2011).
Reduced astrocytic contribution to the turnover of glutamate, glutamine, and GABA characterizes the latent phase in the kainate model of temporal lobe epilepsy.
Journal of Cerebral Blood Flow and Metabolism.
ISSN 0271-678X.
31(8),
s. 1675–1686.
doi:
10.1038/jcbfm.2011.36.
Fulltekst i vitenarkiv
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Håberg, Asta; Qu, Hong & Sonnewald, Ursula
(2009).
Acute changes in intermediary metabolism in cerebellum and contralateral hemisphere following middle cerebral artery occlusion in rat.
Journal of Neurochemistry.
ISSN 0022-3042.
109,
s. 174–181.
doi:
10.1111/j.1471-4159.2009.05940.x.
Fulltekst i vitenarkiv
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Hjørnevik, Trine; Jacobsen, Line Melå; Qu, Hong; Bjaalie, Jan G.; Gjerstad, Johannes & Willoch, Frode
(2008).
Metabolic plasticity in the supraspinal pain modulating circuitry after noxious stimulus-induced spinal cord LTP.
Pain.
ISSN 0304-3959.
140,
s. 456–464.
doi:
10.1016/j.pain.2008.09.029.
Fulltekst i vitenarkiv
Vis sammendrag
It has been suggested that spinal cord long-term potentiation (LTP) may contribute to hypersensitivity and hyperalgesia. We
have investigated if noxious stimulus-induced spinal cord LTP might have a long lasting effect on supraspinal neuronal activity.
First, we verified that spinal LTP was induced by electrical high frequency stimuli (HFS) conditioning applied to the sciatic nerve.
The C-fibre response in the dorsal horn reached a twofold increase 150 min after HFS (t-test, p < 0.01, n = 6). Then, to study the
metabolic supraspinal activity following the same stimulation protocol, we used small animal positron emission tomography (PET)
and the glucose analog [18F]-fluorodeoxyglucose (FDG). With this combined approach we measured changes in regional supraspinal
activity at two time points in HFS conditioned and in sham animals; acute (immediately after HFS/sham, n = 4) and late phase
(150 min after HFS/sham, n = 10). Comparisons between HFS and sham groups revealed that induction of spinal LTP was followed
by an acute metabolic response in the primary somatosensory cortex (S1), but also various slower metabolic adaptations in brain
regions involved in modulation of nociceptive signaling and descending inhibition, i.e., amygdala, periaqueductal gray (PAG), rostral ventromedial medulla (RVM), and the dorsolateral pontomesencephalic tegmentum (DLPT) (t-test, p < 0.05). The study demonstrates that PET may be used as an in vivo method to study regional brain metabolic activity between different conditions. It is
concluded that noxious sciatic stimuli which induce spinal cord LTP also affect supraspinal metabolic activity. We suggest that these
changes might illustrate a supraspinal maladaptive dysfunction involved in pain hypersensitivity and hyperalgesia.
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Alvestad, Silje; Hammer, J; Eyjolfsson, Elvar M.; Qu, H; Ottersen, OP & Sonnewald, Ursula
(2008).
Limbic structures show altered glial-neuronal metabolism in the chronic phase of kainate induced epilepsy.
Neurochemical Research.
ISSN 0364-3190.
33.
doi:
10.1007/s11064-007-9435-5.
Fulltekst i vitenarkiv
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Alvestad, Silje; Hammer, Janniche; Eyjolfsson, E; Qu, Hong; Ottersen, Ole Petter & Sonnewald, U
(2007).
Limbic Structures Show Altered Glial-Neuronal Metabolism in the Chronic Phase of Kainate Induced Epilepsy.
Neurochemical Research.
ISSN 0364-3190.
Fulltekst i vitenarkiv
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Håberg, Asta; Qu, Hong; Hjelstuen, Mari Helene & Sonnewald, Ursula
(2007).
Effect of the pyrrolopyrimidine lipid peroxidation inhibitor U-101033E on neuronal and astrocytic metabolism and infarct volume in rats with transient middle cerebral artery occlusion.
Neurochemistry International.
ISSN 0197-0186.
50(7),
s. 932–940.
doi:
10.1016/j.neuint.2006.12.005.
Fulltekst i vitenarkiv
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Olstad, E; Qu, Hong & Sonnewald, U
(2007).
Glutamate is preferred over glutamine for intermediary metabolism in cultured cerebellar neurons.
Journal of Cerebral Blood Flow and Metabolism.
ISSN 0271-678X.
27.
doi:
10.1038/sj.jcbfm.9600400.
Fulltekst i vitenarkiv
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Olstad, Elisabeth; Qu, Hong & Sonnewald, Ursula
(2007).
Long-term kainic acid exposure reveals compartmentation of glutamate and glutamine metabolism in cultured cerebellar neurons.
Neurochemistry International.
ISSN 0197-0186.
50,
s. 1004–1013.
doi:
10.1016/j.neuint.2006.11.004.
Fulltekst i vitenarkiv
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Olstad, Elisabeth; Qu, Hong & Sonnewald, Ursula
(2007).
Glutamate is preferred over glutamine for intermediary metabolism in cultured cerebellar neurons.
Journal of Cerebral Blood Flow and Metabolism.
ISSN 0271-678X.
27(4),
s. 811–820.
doi:
10.1038/sj.jcbfm.9600400.
Fulltekst i vitenarkiv
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Olstad, Elisabeth; Olsen, Grethe Mari; Qu, Hong & Sonnewald, Ursula
(2007).
Pyruvate recycling in cultured neurons from cerebellum.
Journal of Neuroscience Research.
ISSN 0360-4012.
85(15),
s. 3318–3325.
doi:
10.1002/jnr.21208.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Kortner, Trond Moxness; Qu, Hong; Olstad, Elisabeth; Sunol, Cristina & Bak, L. K.
[Vis alle 8 forfattere av denne artikkelen]
(2006).
Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools.
Neurochemistry International.
ISSN 0197-0186.
48,
s. 572–578.
Fulltekst i vitenarkiv
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Håberg, Asta Kristine; Qu, Hong & Sonnewald, Ursula
(2006).
Glutamate and GABA metabolism in transient and permanent middle cerebral artery occlusion in rat: Importance of astrocytes for neuronal survival.
Neurochemistry International.
ISSN 0197-0186.
48,
s. 531–540.
doi:
10.1016/j.neuint.2005.12.025.
Fulltekst i vitenarkiv
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Waagepetersen, Helle S.; Qu, Hong; Sonnewald, Ursula; Shimamoto, Keiko & Schousboe, Arne
(2005).
Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons.
Neurochemistry International.
ISSN 0197-0186.
47,
s. 92–102.
doi:
10.1016/j.neuint..2005.04.012.
Fulltekst i vitenarkiv
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Qu, Hong; Eloqayli, Haytham & Sonnewald, Ursula
(2005).
Pentylenetetrazole affects metabolism of astrocytes in culture.
Journal of Neuroscience Research.
ISSN 0360-4012.
79.
doi:
10.1002/jnr.20306.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Schousboe, Arne; Qu, Hong & Waagepetersen, Helle S.
(2004).
Intracellular metabolic compartmentation assessed by C-13 magnetic resonance spectroscopy.
Neurochemistry International.
ISSN 0197-0186.
45,
s. 305–310.
Fulltekst i vitenarkiv
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Qu, Hong; Eloqayli, Haytham; Müller, Bernd; Aasly, Jan & Sonnewald, Ursula
(2003).
Glial-neuronal interactions following kainate injection in rats.
Neurochemistry International.
ISSN 0197-0186.
42,
s. 101–106.
Fulltekst i vitenarkiv
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Kondziella, Daniel; Qu, Hong; Lüdemann, Wolf; Brinker, Thomas; Sletvold, Olav & Sonnewald, Ursula
(2003).
Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus.
Journal of Neurochemistry.
ISSN 0022-3042.
85,
s. 274–281.
Fulltekst i vitenarkiv
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Syversen, Tore; Morken, Tora Sund; Urfjell, Bente; Qu, Hong & Sonnewald, Ursula
(2003).
Toxicity of methylmercury in co-cultures of astrocytes and neurons.
The Toxicologist.
ISSN 0731-9193.
72,
s. 67–67.
Fulltekst i vitenarkiv
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Kondziella, Daniel; Qu, Hong; Lüdemann, Wolf; Brinker, Thomas; Sletvold, Olav & Sonnewald, Ursula
(2003).
Astrocyte metabolism is disturbed in the erarly development of experimental hydrocephalus.
Journal of Neurochemistry.
ISSN 0022-3042.
85,
s. 274–281.
Fulltekst i vitenarkiv
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Qu, Hong; Syversen, Tore; Aschner, Michael & Sonnewald, Ursula
(2003).
Effect of methylmercury on glutamate metabolism in cerebellar astrocytes in culture.
Neurochemistry International.
ISSN 0197-0186.
43,
s. 411–416.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; risan, H.B. galtung; hole, H; Qu, Hong & Westergaard, Niels
(2002).
Citrate, beneficial or deleterious in the CNS?
Neurochemical Research.
ISSN 0364-3190.
27,
s. 43–50.
Fulltekst i vitenarkiv
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Eloqayli, Haytham; Qu, Hong; Unsgård, Geirmund; Sletvold, Olav; Hadidi, Hakam & Sonnewald, Ursula
(2002).
Effects of pentylenetetrazole and glutamate on metabolism of [U-13C]glucose in cultured cerebellar granule neurons.
Neurochemistry International.
ISSN 0197-0186.
40(2),
s. 181–187.
doi:
10.1016/S0197-0186(01)00073-0.
Fulltekst i vitenarkiv
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Waagepetersen, Helle S.; Qu, Hong; Hertz, Leif & Schousboe, Arne
(2002).
Demonstration of Pyruvate Recycling in Primary Cultures of Neocortical Astrocytes but Not in Neurons.
Neurochemical Research.
ISSN 0364-3190.
27(11),
s. 1431–1437.
Fulltekst i vitenarkiv
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Johannessen, Cecilie U.; Qu, Hong; Sonnewald, Ursula; Hassel, Bjørnar & Fonnum, Frode
(2001).
Estimation of aspartate synthesis in GABAergic neurons in mice by 13C NMR spectroscopy.
NeuroReport.
ISSN 0959-4965.
12,
s. 3729–3732.
Fulltekst i vitenarkiv
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Qu, Hong; Konradsen, Jon & Sonnewald, Ursula
(2001).
Effect of glutamine and gaba on u-13C-glutamate metabolism in cerebellar astrocytes and granule neurons.
Journal of Neuroscience Research.
ISSN 0360-4012.
66,
s. 885–890.
Fulltekst i vitenarkiv
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Håberg, Asta Kristine; Qu, Hong; Sæther, Oddbjørn; Haraldseth, Olav & Sonnewald, Ursula
(2001).
Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and gabaergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival.
Journal of Cerebral Blood Flow and Metabolism.
ISSN 0271-678X.
21,
s. 1451–1463.
Fulltekst i vitenarkiv
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Waagepetersen, Helle S.; Qu, Hong; Schousboe, Arne & Sonnewald, Ursula
(2001).
Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes.
Journal of Neuroscience Research.
ISSN 0360-4012.
66,
s. 763–770.
Fulltekst i vitenarkiv
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Qu, Hong & Sonnewald, Ursula
(2001).
The effect of thiopental on gutamate metabolism in mouse cerebellar astrocytes in vitro.
Neuroscience Letters.
ISSN 0304-3940.
304,
s. 141–144.
Fulltekst i vitenarkiv
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Qu, Hong; Eloqayli, Haytham; Unsgård, Geirmund & Sonnewald, Ursula
(2001).
Glutamate decreases pyruvate carboxylase activity and spares glucose as energy substrate in cultured cerebellar astrocytes.
Journal of Neuroscience Research.
ISSN 0360-4012.
66,
s. 1127–1132.
Fulltekst i vitenarkiv
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Qu, Hong; Håberg, Asta Kristine; Haraldseth, Olav; Unsgård, Geirmund & Sonnewald, Ursula
(2000).
13C MRS study of lactate as cerebral substrate for rat brain.
Developmental Neuroscience.
ISSN 0378-5866.
22,
s. 429–436.
Fulltekst i vitenarkiv
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Müller, Bernd; Qu, Hong; Gårseth, Mari; White, Linda; Aasly, Jan & Sonnewald, Ursula
(2000).
Amino acid neurotransmitter metabolism in neurons and glia following kainate injection in rats.
Neuroscience Letters.
ISSN 0304-3940.
279,
s. 169–172.
Fulltekst i vitenarkiv
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Qu, Hong; Waagepetersen, Helle S.; Hengel, Marike van; Wolt, Saskia; Dale, Ola & Unsgård, Geirmund
[Vis alle 9 forfattere av denne artikkelen]
(2000).
Effects of thiopental on transport and metabolism of glutamate in cultured cerebellar granule neurons.
Neurochemistry International.
ISSN 0197-0186.
37,
s. 207–215.
Fulltekst i vitenarkiv
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Håberg, Asta Kristine; Qu, Hong; Bakken, Inger Johanne; Sande, Leif Magne; White, Linda & Haraldseth, Olav
[Vis alle 9 forfattere av denne artikkelen]
(1998).
In vitro and ex vivo %1%3C-NMR spectroscopy studies of pyruvate recycling in brain.
Developmental Neuroscience.
ISSN 0378-5866.
20,
s. 389–398.
Fulltekst i vitenarkiv
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Håberg, Asta Kristine; Qu, Hong; Haraldseth, Olav; Unsgård, Geirmund & Sonnewald, Ursula
(1998).
In vivo Injection of 1-13C Glucose and 1,2-13C Acetate Combined With Ex Vivo 13C Nuclear Magnetic Resonance Spectroscopy : A Novel Approachto the Study of Middle Cerebral Artery Occlusion in the Rat.
Journal of Cerebral Blood Flow and Metabolism.
ISSN 0271-678X.
18(11),
s. 1223–1232.
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Se alle arbeider i NVA
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Kristian, Alexandr; Revheim, Mona Elisabeth; Qu, Hong; Mælandsmo, Gunhild; Engebråten, Olav & Malinen, Eirik
(2014).
Dynamic 18F-FDG PET parameters variation in patient-derived breast cancer xenograft and correlation with outcome following treatment with cytotoxic agents.
Cancer Research.
ISSN 0008-5472.
74.
doi:
10.1158/1538-7445.AM2014-2053.
Fulltekst i vitenarkiv
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Alvestad, Silje; Hammer, J; Qu, H; Ottersen, OP & Sonnewald, Ursula
(2009).
Decreased turnover of glutamate, glutamine, and GABA precedes the occurrence of spontaneous seizures in an animal model of temporal lobe epilepsy.
Journal of Neurochemistry.
ISSN 0022-3042.
109,
s. 273–273.
Fulltekst i vitenarkiv
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Hjornevik, Trine; Qu, Hong; Gjerstad, J; Jacobsen, Line Melå; Bjaalie, Jan G. & Willoch, Frode
(2009).
Rat model of pathological pain in the central nervous system.
Journal of Neurochemistry.
ISSN 0022-3042.
109,
s. 309–309.
Fulltekst i vitenarkiv
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Håberg, Asta; Qu, Hong & Sonnewald, Ursula
(2008).
Metabolic changes in contralateral hemisphere and cerebellum in acute stroke and their possible implications in functional recovery.
Fulltekst i vitenarkiv
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Hjørnevik, Trine; Jacobsen, Line Melå; Qu, Hong; Bjaalie, Jan G.; Gjerstad, Johannes & Willoch, Frode
(2008).
Induction of spinal LTP results in activity-dependent plastic changes in pain modulatory of brain and brain stem.
Fulltekst i vitenarkiv
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Hjørnevik, Trine; Qu, Hong; Gjerstad, Johannes; Jacobsen, Line Melå; Bjaalie, Jan G. & Willoch, Frode
(2008).
Rat model of pathological pain in the central nervous system.
Fulltekst i vitenarkiv
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Hjørnevik, Trine; Darine, Dmitri Aleksandrovitsj; Qu, Hong; Willoch, Frode; Leergaard, Trygve Brauns & Bjaalie, Jan G.
(2008).
Three dimensional atlas system for mouse and rat brain imaging data.
Fulltekst i vitenarkiv
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Alvestad, Silje; Hammer, Janniche; Qu, Hong; Ottersen, Ole Petter & Sonnewald, Ursula
(2008).
Decreased turnover of glutamate, glutamine, and GABA precedes the occurrence of spontaneous seizures in an animal model of temporal lobe epilepsy.
Fulltekst i vitenarkiv
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Qu, Hong
(2007).
Small Animal Imaging Facility at Center of Molecular Biology and Neuroscience (CMBN).
Fulltekst i vitenarkiv
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Qu, Hong; Hjørnevik, Trine; Bjaalie, Jan G. & Willoch, Frode
(2007).
microPET in preclinical research-summary of two years' learning.
Fulltekst i vitenarkiv
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Hjørnevik, Trine; Leergaard, Trygve Brauns; Darine, Dmitri Aleksandrovitsj; Qu, Hong; Willoch, Frode & Bjaalie, Jan G.
(2007).
Three-dimensional atlas system for mouse and rat brain imaging data.
Fulltekst i vitenarkiv
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Håberg, Asta; Qu, Hong; Haraldseth, Olav & Sonnewald, Ursula
(2006).
Effect of U-101033E in transient middle cerebral artery occlusion in rat evaluated with in vivo diffusion weighted MRI and ex vivo 13C NMR spectroscopy.
Fulltekst i vitenarkiv
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Olstad, Elisabeth; Qu, Hong & Sonnewald, Ursula
(2006).
Effect of kainic acid on glutamate metabolism in cultured neurons.
Journal of Neurochemistry.
ISSN 0022-3042.
96,
s. 47–47.
Fulltekst i vitenarkiv
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Olstad, Elisabeth; Qu, Hong & Sonnewald, Ursula
(2006).
Effect of Kainic Acid on Glutamate Metabolism in Cultured Neurons.
Fulltekst i vitenarkiv
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Håberg, Asta Kristine; Qu, Hong; Sonnewald, Ursula & Haraldseth, Olav
(2005).
neuronal and astrocytic metabolism in succesfully and unsuccesfully reperfused tissue following middle cerebral artery occlusion in rat.
Fulltekst i vitenarkiv
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Alvestad, Silje; Brekken, Christian; Hammer, Janniche; Qu, Hong & Sonnewald, Ursula
(2005).
Epileptogenesis: Brain Structure and Metabolism During the Latent Period Following Kainate-Induced Seizures in Rats.
Fulltekst i vitenarkiv
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Hammer, Janniche; Alvestad, Silje; Qu, Hong; Risa, Øystein; Osen, Karen & Ottersen, Ole Petter
[Vis alle 7 forfattere av denne artikkelen]
(2005).
Glial-Neuronal Interactions during the latent and chorinc periods following kainate induced seizures in Rats.
Journal of Neurochemistry.
ISSN 0022-3042.
94,
s. 64-128–64-128.
Fulltekst i vitenarkiv
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Håberg, Asta; Qu, Hong & Sonnewald, Ursula
(2005).
13C NMRS for studies of glutamate and GABA metabolism.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Olstad, Elisabeth; Qu, Hong; Kortner, Trond Moxness; Schousboe, Arne & Waagepetersen, Helle S.
(2004).
GABA in cultured glutamaterigic neurons from cerebellum.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Olstad, Elisabeth; Qu, Hong; Kortner, Trond Moxness; Schousboe, Arne & Waagepetersen, Helle S.
(2004).
GABA in cultured glutamatergic neurons from cerebellum.
Journal of Neurochemistry.
ISSN 0022-3042.
90,
s. 31–31.
Fulltekst i vitenarkiv
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Syversen, T; Morken, Tora Sund; Urfjell, B; Qu, H; Aschner, M & Sonnewald, U
(2004).
Toxicity of methylmercury in co-cultures of astrocytes and neurons.
Toxicology and Applied Pharmacology.
ISSN 0041-008X.
197,
s. 322–322.
Fulltekst i vitenarkiv
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Syversen, Tore; Morken, Tora Sund; Urfjell, Bente; Qu, Hong; Aschner, Michael & Sonnewald, Ursula
(2004).
Toxicity of methylmercury in co-cultures of astrocytes and neurons.
Fulltekst i vitenarkiv
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Håberg, Asta Kristine; Qu, Hong & Sonnewald, Ursula
(2004).
Glutamatatergic activity severely impaired in the contralateral hemisphere in the acute phase og middle cerebral artery occlusion in rats.
Fulltekst i vitenarkiv
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Brenner, E.; Qu, Hong & Sonnewald, Ursula
(2003).
The effect of pentylene tetrazole on glutamate metabolism in cortical and cerebellar astrocytes.
Journal of Neurochemistry.
ISSN 0022-3042.
87,
s. 89–89.
Fulltekst i vitenarkiv
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Sonnewald, Ursula & Qu, Hong
(2003).
Metabolism of excitatory amino acids in cultured astrocytes and neurons studied by MRS.
Journal of Neurochemistry.
ISSN 0022-3042.
87,
s. 40–40.
Fulltekst i vitenarkiv
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Olstad, Elisabeth; Qu, Hong & Sonnewald, Ursula
(2003).
Effect of kainate on cerebellar granule neurons.
Journal of Neurochemistry.
ISSN 0022-3042.
87,
s. 40–40.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Qu, Hong; Waagepetersen, Helle S. & Schousboe, Arne
(2003).
Metabolic compartmentation assessed by 13C magentic resonance spectroscopy: the pharmacology and toxicology of astrocyte-neuron glutamate cycling.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Qu, Hong; Waagepetersen, Helle S. & Schousboe, Arne
(2003).
MRS studies of neuronal/glial interatctions.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Waagepetersen, Helle S.; Qu, Hong & Schousboe, Arne
(2002).
New aspects of amino acid neurotransmitter synthesis in cultured neurons.
Fulltekst i vitenarkiv
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Olstad, Elisabeth; Qu, Hong & Sonnewald, Ursula
(2002).
Alterations in cerebral metabolism by the neurotoxin kainic acid studied by 13C MRS.
Fulltekst i vitenarkiv
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Qu, Hong; Qu, Hong; Sonnewald, Ursula & Håberg, Asta Kristine
(1999).
Is serum (U-13C)lactate a substrate in rat brain?
Fulltekst i vitenarkiv
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Waagepetersen, Helle S.; Sonnewald, Ursula; Qu, Hong & Schousboe, Arne
(1999).
Mitochondrial compartmentation at the cellular level- Astrocytes and neurons.
Fulltekst i vitenarkiv
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Waagepetersen, Helle S.; Sonnewald, Ursula; Qu, Hong & Schousboe, Arne
(1999).
Mitochondrial compartmentation at the cellular level: astrocytes and neurons.
Fulltekst i vitenarkiv
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Qu, Hong; Håberg, Asta Kristine; Sæter, Oddbjørn; Haraldseth, Olav; Unsgård, Geirmund & Sonnewald, Ursula
(1998).
Pyruvate recycling.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Håberg, Asta Kristine; Qu, Hong; Sæter, Oddbjørn; Haraldseth, Olav & Unsgård, Geirmund
(1998).
Stroke, the metabolic approach.
Fulltekst i vitenarkiv
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Sonnewald, Ursula; Håberg, Asta Kristine; Qu, Hong; Haraldseth, Olav; Müller, Tom B. & Unsgård, Geirmund
(1997).
Neuronal/glial metabolism after middle cerebral artery occlusion in rats studied by 13C MRS.
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Publisert
13. apr. 2011 11:04
- Sist endret
4. des. 2019 15:23