Bjørn Steen Skålhegg

Bilde av Bjørn Steen Skålhegg
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Telefon +47-22851548
Rom 2198
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO
Postadresse Postboks 1046 Blindern 0317 OSLO
Andre tilknytninger Avdeling for ernæringsvitenskap

Faglige interesser

  • Molekylær ernæring

  • Integrert metabolisme

  • Signal transduksjon

  • Immunologi

  • Kreft

Undervisning

Bakgrunn

  • Cand scient. Biokjemi UiO 1988

  • Dr. philos UiO 1993

Priser og bevilgninger

-2018-2021                 Granted FRIMEDBIO from the Norwegian Research Council

-2017-2019                 Granted Scienta Fellow, joint funding by the Medical Faculty, University of Oslo and EU

-2017-2021                 Granted PhD student fellowship funded bythe Institute of Basic Medical Sciences, University of Oslo

- 2016-2019                Grant from the Norwegian Research Council, HELSEVEL. ImNut, Head Dr. Sissel Moltu, Oslo University Hospital.

- 2017 - 2020                          Granted PhD fellow Fellowship from Helse Sør-Øst, Co-supervisor with Dr. Johanna Hol, Oslo University Hospital.

- 2013 - 2016                          Grant from the Norwegian Research Council, FRIBIO

- 2013 - 2016                          Grant from the Norwegian Cancer Society

- 2013 -                                   Grant from the Throne Holst foundation (UiO)

- 2002-2005 and 2006-2009   Finalist (10 top) for center of excellence (COE/SFF)

- 1996 until 1999                     Research grants received from the Norwegian Research Council.

- 1994 until 1995                     Fulbright Fellow

- 1993 until 1996                     Post doctor Norwegian Research Council

- 1988 until 1993                     PhD fellow from The Norwegian Cancer Society.

 

Verv

  • -           Board member of the NOR-OPENSCREEN (HTS) Node Norway (2016-)

    -           Head of Division for Molecular Nutrition (2015-)

    -           Member of the National Advisory Board for Disease Related Mal Nutrition (2015-2019)

    -           Head of Molecular Nutrition Unit (MolNU) (2014-)

    -           Grant reviewer for the Norwegian Research Council, (2013-)

    -           Member of the National Reference Group on Laboratory Genetics and Gene Technology appointed by The Norwegian Directorate of Health. (2013-)

    -           Member of the committee on food safety in Norway (VKM), appointed by the Royal Department of Health (2012-).

    -           Substitute member of the board of representatives of the Norwegian Cancer Society (2011-)

    -           Member of the Computational Life Science Initiative (CLSi), University of Oslo (2009-).

    -           Grant reviewer for the Norwegian Cancer Society (2007-2012 + 2014)

    -           Member of the committee for Life Science at the University of Oslo (2007-2010)

    -           Head of the border for Functional genomics (FUGE) initiative on micro array at the University of Oslo (2005-2008).

    -           Co-founder, shareholder, board head and -member of the biotech companies Spermatech and Rheumatech (since 2002), and Arctic Pharma (since 2012). All companies established according to own research

  • -           Board member Department of Nutrition, University of Oslo (2006-10).

  • -           Board member Throne Holst Foundation (2008-9).

Samarbeid

 

Professor Tore Kvien, Dr. Guro Goll Løvik, Diakonsykehuset, Oslo.

Associated Professor Jon K. Lærdal, UiO

Dr. Sheraz Yakub og Dr Knut Jørgen Labori, Kirurger og veildere, Oslo Universitetssykehus.

Professor Tone Frost Bathen, NTNU

Professor Ian Mills, Queens University, Belfast, Irland

Professor Daan van Aalten, FRSE, Wellcome Trust Investigator School of Life Sciences University of Dundee, Scotland, United Kingdom

Professor Friedrich Herberg, Kassel University, Germany.

Emneord: Ernæring, Integrert metabolisme, Immunologi, Kreft

Publikasjoner

  • Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner. Volchenkov R, Nygaard V, Sener Z, Skålhegg BS. Front Immunol. 2017 Jun 19;8:698. doi: 10.3389/fimmu.2017.00698.

  • Ablation of the Cβ2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice. Moen LV, Sener Z, Volchenkov R, Svarstad AC, Eriksen AM, Holen HL, Skålhegg BS. Eur J Immunol. 2017 Aug 24. doi: 10.1002/eji.201646809.

  • Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms.Søberg K, Moen LV, Skålhegg BS, Laerdahl JK. PLoS One. 2017 Jul 25;12(7):e0181091. doi: 10.1371/journal.pone.0181091.

  • The level of Cβ2 of Protein kinase A may be used as a biomarker in combination with Gleason Score to predict prostate cancer aggressiveness. Line Victoria Moen, Hakon Ramberg, Sen Zhao, Anita Sveen, Helene Hartvedt Grytli, Viktor Berge, Rolf Skotheim, Kristin Austlid Tasken, and Bjørn Steen Skalhegg. Urological Oncology, (2016) doi: 10.1016/j.urolonc.2016.10.002.

  • T Helper cell activation and differentiation is sensitive to glutaminase inhibition under both hypoxic and normoxic conditions. Sener Z., Cederkvist F.H., Volchenkov R., Holen H.L. and Skålhegg B.S. PlosONE (2016) Jul 28;11(7):e0160291. doi: 10.1371.

  • Metabolic profiling of synovial tissue shows altered glucose and choline metabolism in rheumatoid arthritis samples. Volchenkov R, Dung Cao M, Elgstøen KB, Goll GL, Eikvar K, Bjørneboe O, Bathen TF, Holen HL, Kvien TK, Skålhegg BS. Scand J Rheumatol. 2016 Apr 21:1-2. [Epub ahead of print]

  • Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits. Søberg K, Jahnsen T, Rognes T, Skålhegg BS, Laerdahl JK. PLoS One. 2013 Apr 12;8(4):e60935. Print 2013

  • Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Cα of Protein Kinase A (PKA). Kristoffer Søberg, Anja C.V. Larsen, Mandy Diskar, Paul H. Backe, Tore Jahnsen, Jon K. Laerdahl, Torbjørn Rognes, Friedrich Herberg, and Bjørn S. Skålhegg. PlosONE. (2012); 7(4):e34838. Epub Apr 13.

  • Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa. T.H. Hereng, K.B.P. Elgstøen, F.H. Cederkvist, T. Jahnsen, B.S. Skålhegg, and K.R. Rosendal Hum Reprod. (2011) Dec;26(12):3249-63. doi: 10.1093/humrep/der317 Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Ane Funderud, Kristin Aas-Hanssen, Anne Kristin Aksaas, Tilahun T. Hafte, Alexandre Corthay, Ludvig A. Munthe, Sigurd Ørstavik, Bjørn S. Skålhegg. Cellular Signalling 21 (2009) 274–281. 

  • Exon skipping generates inactive forms of the catalytic subunit of PKA primarily expressed in the brain of higher primates. Anja C. V. Larsen, Anne-Katrine Kvissel, Tilahun T. Hafte, Cecilia I. A. Avellan, Sissel Eikvar, Terje Rootwelt, Sigurd Ørstavik, Bjørn S. Skålhegg. FEBS J. (2008) Jan;275(2):250-62.

  • Localization of the PKA catalytic subunit to splicing factor compartments and regulation of pre-mRNA splicing in vivo. Kvissel, A-K., S. Ørstavik, S. Eikvar, G. Brede, T. Jahnsen, P. Collas, G. Akusjarvi and B.S. Skalhegg. Exp. Cell Res, (2007) Aug 1;313(13):2795-809.

  • Towards turning fibroblasts into T cells: reprogramming of fibroblast function in a cell-free extract. Anne-Mari Håkelien, Helga B. Landsverk, James M. Robl, Bjørn S. Skålhegg, and Philippe Collas. Nature Biotechnology, (2002) 20, 460-46.

  • Mutation of the Calpha Subunit of PKA Leads to Growth Retardation and Sperm Dysfunction. Skålhegg, B.S., Huang, Y., Su, T., Idzerda, R., G.S. McKnight and Burton, K.A. Mol. Endo (2002) 16, 630-639.

  • A novel isoform of human cAMP-dependent protein kinase, CαS, localized to sperm midpiece. Reinton, N., Ørstavik., S., Haugen, T.B., Taskén, K., T. Jahnsen and. B.S. Skålhegg. Biol Reprod (2000) 63, 607-11.

  • Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. Witczak, O., Skålhegg, B.S., Keryer, G., Bornens, M., Taskén, K., Jahnsen, T., and Ørstavik, S. EMBO Journal (1999) 18: 1905-1914.

  • Two novel brain specific splice variants of the murine Cα gene cAMP-dependent protein kinase. Guthrie, C., B.S. Skålhegg, and G.S. McKnight. Journal of Biological Chemistry (1997) 272 (47) 29560.

  • Location of cAMP-dependent protein kinase type I with the TCR/CD3 complex Skålhegg, B.S., Taskén, K., Hansson, V., Huifeldt, H.S., Jahnsen, T., and Lea, T. Science (1994) 263, 84-87.

  • Gjevestad, Gyrd Omholt; Ottestad, Inger; Biong, Anne Sofie; Iversen, Per Ole; Retterstøl, Kjetil; Raastad, Truls; Skålhegg, Bjørn Steen; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2017). Consumption of protein-enriched milk has minor effects on inflammation in older adults?A 12-week double-blind randomized controlled trial. Mechanisms of Ageing and Development.  ISSN 0047-6374.  162, s 1- 8 . doi: 10.1016/j.mad.2017.01.011 Vis sammendrag
  • Moen, Line Victoria; Ramberg, Håkon Andre; Zhao, Sen; Grytli, Helene Hartvedt; Sveen, Anita; Berge, Viktor; Skotheim, Rolf I.; Tasken, Kristin Austlid & Skålhegg, Bjørn Steen (2017). Observed correlation between the expression levels of catalytic subunit, C?2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness. Urologic Oncology.  ISSN 1078-1439.  35(3), s 111.e1- 111.e8 . doi: 10.1016/j.urolonc.2016.10.002 Vis sammendrag
  • Stakkestad, Øystein; Lyngstadaas, Ståle Petter; Thiede, Bernd; Vondrasesek, Jiri; Skålhegg, Bjørn Steen & Reseland, Janne Elin (2017). Phosphorylation Modulates Ameloblastin Self-assembly and Ca2+ Binding. Frontiers in Physiology.  ISSN 1664-042X.  8 . doi: 10.3389/fphys.2017.00531
  • Søberg, Kristoffer; Moen, Line Victoria; Skålhegg, Bjørn Steen & Lærdahl, Jon Kristen (2017). Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms.. PLoS ONE.  ISSN 1932-6203.  12:e0181091(7), s 1- 17 . doi: 10.1371/journal.pone.0181091
  • Volchenkov, Roman; Nygaard, Vegard; Sener, Zeynep & Skålhegg, Bjørn Steen (2017). Th17 polarization under hypoxia results in increased IL-10 production in a pathogen-independent manner. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.00698
  • Sener, Zeynep; Cederkvist, Fritjof Henning; Volchenkov, Roman; Holen, Halvor Laustad & Skålhegg, Bjørn Steen (2016). T helper cell activation and expansion is sensitive to glutaminase inhibition under both hypoxic and normoxic conditions. PLoS ONE.  ISSN 1932-6203.  11(7) . doi: 10.1371/journal.pone.0160291
  • Hereng, Tuva Holt; Elgstøen, Katja B. Prestø; Eide, Lars; Rosendal, Ken Roger & Skålhegg, Bjørn Steen (2014). Serum albumin and HCO<sub>3</sub><sup>-</sup> regulate separate pools of ATP in human spermatozoa. Human Reproduction.  ISSN 0268-1161.  29(5), s 918- 930 . doi: 10.1093/humrep/deu028
  • Søberg, Kristoffer; Jahnsen, Tore; Rognes, Torbjørn; Skålhegg, Bjørn Steen & Lærdahl, Jon Kristen (2013). Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits. PLoS ONE.  ISSN 1932-6203.  8(4) . doi: 10.1371/journal.pone.0060935 Fulltekst i vitenarkiv.
  • Hereng, Tuva Holt; Backe, Paul Hoff; Kahmann, Jan; Scheich, Christoph; Bjørås, Magnar; Skålhegg, Bjørn Steen & Rosendal, Ken Roger (2012). Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit C alpha 2. Journal of Structural Biology.  ISSN 1047-8477.  178(3), s 300- 310 . doi: 10.1016/j.jsb.2012.03.013
  • Persson, Heidi Törmänen; Aksaas, Anne Kristin; Kvissel, Anne Katrine; Punga, Tanel; Engström, Åke; Skålhegg, Bjørn Steen & Akusjärvi, Göran (2012). Two cellular protein kinases, DNA-PK and PKA, phosphorylate the adenoviral L4-33K protein and have opposite effects on L1 alternative RNA splicing. PLoS ONE.  ISSN 1932-6203.  7(2) . doi: 10.1371/journal.pone.0031871
  • Søberg, Kristoffer; Larsen, Anja C V; Diskar, Mandy; Backe, Paul Hoff; Bjørås, Magnar; Jahnsen, Tore; Lærdahl, Jon Kristen; Rognes, Torbjørn; Herberg, Friedrich W. & Skålhegg, Bjørn Steen (2012). Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA). PLoS ONE.  ISSN 1932-6203.  7(4) . doi: 10.1371/journal.pone.0034838
  • Aksaas, Anne Kristin; Eikvar, Sissel; Akusjervi, Goran; Skålhegg, Bjørn Steen & Kvissel, Anne Katrine (2011). Protein kinase A-dependent phosphorylation of serine 119 in the proto-oncogenic Serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein. Genes, Chromosomes and Cancer.  ISSN 1045-2257.  2(8), s 841- 851
  • Aksaas, Anne Kristin; Larsen, Anja C V; Rogne, Marie; Rosendal, Ken Roger; Kvissel, Anne Katrine & Skålhegg, Bjørn Steen (2011). G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. Journal of Molecular Signaling.  ISSN 1750-2187.  6, s 1- 14
  • Hereng, Tuva Holt; Elgstøen, Katja B. Prestø; Cederkvist, Fritjof Henning; Eide, Lars; Jahnsen, Tore; Skålhegg, Bjørn Steen & Rosendal, K.R (2011). Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa. Human Reproduction.  ISSN 0268-1161.  26(12), s 3249- 3263 . doi: 10.1093/humrep/der317
  • Stakkestad, Øystein; Larsen, Anja C V; Kvissel, Anne Katrine; Eikvar, Sissel; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2011). Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform. BMC Biochemistry.  ISSN 1471-2091.  12 . doi: 10.1186/1471-2091-12-7
  • Vetter, Maike; Zenn, Hans M.; Mendez, Eva; van den Boom, Heidrun; Herberg, Friedrich W. & Skålhegg, Bjørn Steen (2011). The testis-specific C alpha 2 subunit of PKA is kinetically indistinguishable from the common C alpha 1 subunit of PKA. BMC Biochemistry.  ISSN 1471-2091.  12 . doi: 10.1186/1471-2091-12-40
  • Haugen, Fred; Norheim, Frode; Lian, Henrik; Wensaas, Andreas Johansen; Dueland, Svein; Berg, Ole; Funderud, Ane; Skålhegg, Bjørn Steen; Raastad, Truls & Drevon, Christian A (2010). IL-7 is expressed and secreted by human skeletal muscle cells. American Journal of Physiology - Cell Physiology.  ISSN 0363-6143.  298(4), s C807- C816 . doi: 10.1152/ajpcell.00094.2009 Vis sammendrag
  • Funderud, Ane; Aas-Hanssen, Kristin; Aksaas, Anne Kristin; Hafte, Tolesa Tilahun; Corthay, Alexandre; Munthe, Ludvig Andre; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2009). Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cellular Signalling.  ISSN 0898-6568.  21(2), s 274- 281 . doi: 10.1016/j.cellsig.2008.10.013
  • Jarnæss, Elisabeth; Stokka, Anne Jorunn; Kvissel, Anne Katrine; Skålhegg, Bjørn Steen; Torgersen, Knut Martin; Scott, John D.; Carlson, Cathrine Rein & Tasken, Kjetil (2009). Splicing Factor Arginine/Serine-rich 17A (SFRS17A) Is an A-kinase Anchoring Protein That Targets Protein Kinase A to Splicing Factor. Journal of Biological Chemistry.  ISSN 0021-9258.  284(50), s 35154- 35164 . doi: 10.1074/jbc.M109.056465
  • Kloster, Martine Müller; Hafte, Tolesa Tilahun; Moltzau, Lise Roman; Hallan, Elin; Dahle, Maria Krutå; Skålhegg, Bjørn Steen; Gaudernack, Gustav; Levy, Finn Olav; Naderi, Soheil & Blomhoff, Heidi Kiil (2008). EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase. Cellular Signalling.  ISSN 0898-6568.  20(6), s 1169- 1178 . doi: 10.1016/j.cellsig.2008.02.007
  • Larsen, Anja C V; Kvissel, Anne Katrine; Hafte, Tolesa Tilahun; Avellan, Cecilia I. A.; Eikvar, Sissel; Rootwelt, Terje; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2008). Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates. The FEBS Journal.  ISSN 1742-464X.  275(2), s 250- 262 . doi: 10.1111/j.1742-4658.2007.06195.x
  • Oksvold, Morten Pedersen; Funderud, Ane; Kvissel, Anne Katrine; Skarpen, Ellen; Henanger, Heidi Hatledal; Huitfeldt, Henrik; Skålhegg, Bjørn Steen & Ørstavik, Sigurd (2008). Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit. BMC Cell Biology.  ISSN 1471-2121.  9 . doi: 10.1186/1471-2121-9-16
  • Skarpen, Ellen; Flinder, LI; Rosseland, CM; Ørstavik, Sigurd; Wierod, L; Oksvold, MP; Skålhegg, Bjørn Steen & Huitfeldt, HS (2008). MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments. The FASEB Journal.  ISSN 0892-6638.  22 . doi: 10.1096/fj.07-8650com
  • Kvissel, Anne Katrine; Ramberg, Håkon; Eide, Turid; Svindland, Aud; Skålhegg, Bjørn Steen & Tasken, Kristin Austlid (2007). Androgen dependent regulation of protein kinase A subunits in prostate cancer cells. Cellular Signalling.  ISSN 0898-6568.  19(2), s 401- 409 . doi: 10.1016/j.cellsig.2006.07.011
  • Kvissel, Anne Katrine; Ørstavik, Sigurd; Eikvar, Sissel; Brede, Gaute; Jahnsen, Tore; Collas, Philippe; Akusjarvi, G & Skålhegg, Bjørn Steen (2007). Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing. PMID: 17594903 [PubMed - in process]. Experimental Cell Research.  ISSN 0014-4827.  313, s 2795- 2809 . doi: 10.1016/j.yexcr.2007.05.014
  • Pedersen, Elena Didenko; Ellingsrud, Elisabeth; Kvissel, Anne Katrine; Pharo, Anne Margrethe; Skålhegg, Bjørn Steen; Rootwelt, Terje & Mollnes, Tom Eirik (2007). Expression of complement regulators and receptors on human NT2-N neurons - Effect of hypoxia and reoxygenation. Molecular Immunology.  ISSN 0161-5890.  44(9), s 2459- 2468 . doi: 10.1016/j.molimm.2006.10.022 Vis sammendrag
  • Skarpen, Ellen; Flinder, Liv; Rosseland, Carola; Ørstavik, Sigurd; Wierød, Lene; Oksvold, Morten Pedersen; Skålhegg, Bjørn Steen & Huitfeldt, Henrik (2007). MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments. The FASEB Journal.  ISSN 0892-6638.
  • Frøyland, Elisabeth; Pedersen, Elena Didenko; Kvissel, Anne Katrine; Almaas, R; Pharo, Anne Margrethe; Skålhegg, Bjørn Steen; Mollnes, Tom Eirik & Rootwelt, T (2006). Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons. Brain Research.  ISSN 0006-8993.  1113, s 64- 73
  • Skålhegg, Bjørn Steen; Løken, Elin Bjørge; Klepp, Knut Inge & Rimestad, Arnhild Haga (2006). Matens innhold av energi. Norsk tidsskrift for ernæring.  ISSN 1503-5034.  (1), s 18- 19
  • Funderud, Ane; Henanger, Heidi; Hafte, Tolesa Tilahun; Ameuix, Paul; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2006). Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2. BMC Biochemistry.  ISSN 1471-2091.  7, s 20- 27
  • Håkelien, Anne-Mari; Gaustad, Kristine Gjul; Taranger, Christel Kjær; Skålhegg, Bjørn Steen; Kuntziger, Thomas Michel & Collas, Philippe (2005). Long-term in vitro, cell-type-specific genome-wide reprogramming of gene expression. Experimental Cell Research.  ISSN 0014-4827.  10, s 32- 47
  • Orstavik, Sigurd; Funderud, Ane; Hafte, Tolesa Tilahun; Eikvar, Sissel; Jahnsen, Tore & Skålhegg, Bjørn Steen (2005). Identification and characterization of novel PKA holoenzymes in human T lymphocytes. The FEBS Journal.  ISSN 1742-464X.  272, s 1559- 1567
  • Skålhegg, Bjørn Steen; Funderud, Ane; Henanger, HH; Hafte, Tolesa Tilahun; Larsen, Anja Camilla Vogeler; Kvissel, Anne Katrine; Eikvar, Sissel & Orstavik, Sigurd (2005). Protein kinase A (PKA) - A potential target for therapeutic intervention of dysfunctional immune cells. Current Drug Targets.  ISSN 1389-4501.  6
  • Fredriksen, Jannicke; Ueland, Thor; Dyrøy, E; Halvorsen, Bente; Melby, K; Melbye, L; Skålhegg, Bjørn Steen; Bohov, P; Skorve, Jon; Berge, RK; Aukrust, Pål & Frøland, Stig Sophus (2004). Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapy. European Journal of Clinical Investigation.  ISSN 0014-2972.  34(10), s 709- 715
  • Kvissel, Anne Katrine; Ørstavik, Sigurd; Øistad, P; Rootwelt, Terje; Jahnsen, Tore & Skålhegg, Bjørn Steen (2004). Induction of Cbeta splice variants and formation of novel forms of protein kinase A type II holoenzymes during retinoic acid-induced differentiation of human NT2 cells. Cellular Signalling.  ISSN 0898-6568.  16(5), s 577- 587 Vis sammendrag
  • Gutzkow, Kristine B; Låhne, Hege U; Naderi, Soheil; Torgersen, Knut Martin; Skålhegg, Bjørn Steen; Koketsu, Mamoru; Uehara, Yoshimasa & Blomhoff, Heidi Kiil (2003). Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation. Cellular Signalling.  ISSN 0898-6568.  15, s 871- 881
  • Tasken, Kjetil; Hansson, V; Aukrust, Pål; Frøland, Stig Sophus; Skålhegg, Bjørn Steen; Muller, Fredrik; Tobin, Derek; Vang, Torkel; Torgersen, Knut Martin & Aandahl, Einar Martin (2003). PKAI as a potential target for therapeutic intervention. Drug News and Perspectives.  ISSN 0214-0934.  1, s 12- 18
  • Mendez, Eva; Mæland, Mari; Skålhegg, Bjørn Steen & Planas, Josep (2003). Activation of the cAMP-dependent protein kinase signaling pathway by luteinizing hormone in trout theca layers. Molecular and Cellular Endocrinology.  ISSN 0303-7207.  205(1-2), s 11- 20 . doi: 10.1016/S0303-7207(03)00208-9
  • Håkelien, Anne-Mari; Landsverk, H.B.; Robl, J.M.; Skålhegg, Bjørn Steen & Collas, Philippe (2002). Reprogramming of fibroblast function in a cell-free extract. Nature Biotechnology.  ISSN 1087-0156.  (20), s 460- 466
  • Landsverk, Helga B.; Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Robl, J.M.; Skålhegg, Bjørn Steen & Collas, Philippe (2002). Reprogrammed gene expression in a somatic cell-free extract. EMBO Reports.  ISSN 1469-221X.  3(4), s 384- 389
  • Tasken, Kjetil & Skålhegg, Bjørn Steen (2002). Protein kinase A Cgamma (PKA-Cgamma). Alliance for Cellular Signalling.
  • Tasken, Kjetil; Skålhegg, Bjørn Steen & Ørstavik, Sigurd (2002). Protein kinase A Cbeta (PKA-Cbeta). Alliance for Cellular Signalling.
  • Hoover, Frank; Kalhovde, John Magne; Dahle, Maria Krutå; Skålhegg, Bjørn Steen; Tasken, Kjetil & Lømo, Terje (2002). Electrical muscle activity pattern and transcriptional and post-transcriptional mechanisms regulate the PKA subunit expression in rat skeletal muscle. Molecular and Cellular Neuroscience.  ISSN 1044-7431.  19, s 125- 137
  • Vang, Torkel; Torgersen, Knut Martin; Gjerstad, Vibeke Sundvold; Saxena, Manju; Levy, Finn Olav; Skålhegg, Bjørn Steen; Hansson, Vidar; Mustelin, Tomas & Tasken, Kjetil (2001). Activation of Csk by cAMP-dependent protein kinase inhibits signalling through the T-cell receptor. Journal of Experimental Medicine.  ISSN 0022-1007.  193, s 497- 507
  • Ørstavik, Sigurd; Reinton, Nils Torgny Kjelkevik; Frengen, Eirik; Langeland, Bjørn Tore; Jahnsen, Tore & Skålhegg, Bjørn Steen (2001). Identification of novel splice variants of the human catalytic subunit cbeta of cAMP-dependent protein kinase. European Journal of Biochemistry.  ISSN 0014-2956.  268(19), s 5066- 5073 Vis sammendrag
  • Tasken, Kjetil; Hansson, Vidar; Aukrust, Pål; Frøland, Stig Sophus; Skålhegg, Bjørn Steen; Muller, Fredrik; Tobin, Derek; Vang, Torkel; Torgersen, Knut Martin & Aandahl, Einar Martin (2000). Protein kinase a type I as a potential target for therapeutic intervention. Drug News and Perspectives.  ISSN 0214-0934.  13, s 12- 18
  • Hansson, Vidar; Skålhegg, Bjørn Steen & Tasken, Kjetil (2000). Cyclic AMPdependent protein kinase in testicular  specificity in the cAMP signalling pathway. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  73, s 81- 92
  • Martins, Sandra B.; Eide, Turid; Steen, Rikke L.; Jahnsen, Tore; Skålhegg, Bjørn Steen & Collas, Philippe (2000). HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. Journal of Cell Science.  ISSN 0021-9533.  113, s 3730- 3713 Vis sammendrag
  • Reinton, Nils Torgny Kjelkevik; Collas, Philippe; Haugen, T. B.; Skålhegg, Bjørn Steen; Hansson, Vidar; Jahnsen, Tore & Tasken, Kjetil (2000). Localization of a Novel Human A-Kinase-Anchoring Protein, hAKAP220, during Spermatogenesis. Developmental Biology.  ISSN 0012-1606.  223, s 194- 204
  • Reinton, Nils Torgny Kjelkevik; Ørstavik, Sigurd; Haugen, T. B.; Tasken, Kjetil; Jahnsen, Tore & Skålhegg, Bjørn Steen (2000). A novel isoform of human cAMP-dependent protein kinase, Ca-s, localized to sperm midpiece. Biology of Reproduction.  ISSN 0006-3363.  63, s 607- 611
  • Reinton, Nils Torgny Kjelkevik; Ørstavik, Sigurd; Haugen, T. B.; Tasken, Kjetil; Jahnsen, Tore & Skålhegg, Bjørn Steen (2000). A novel isoform of human cAMP-dependent protein kinase, Ca-s, localized to sperm midpiece. Biology of Reproduction.  ISSN 0006-3363.  63, s 607- 611
  • Skålhegg, Bjørn Steen & Tasken, Kjetil (2000). Specificity in the cAMP/PKA signalling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Frontiers in Bioscience.  ISSN 1093-9946.  5, s d678- 693
  • Ørstavik, Sigurd; Eide, Turid; Collas, Philippe; Han, Innoc O.; Tasken, Kjetil; Kieff, Elliot; Jahnsen, Tore & Skålhegg, Bjørn Steen (2000). Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to the A-kinase anchoring protein, AKAP95. Biology of the Cell.  ISSN 0248-4900.  92, s 27- 37
  • Aukrust, Pål; Aandahl, Einar Martin; Skålhegg, Bjørn Steen; Nordøy, Ingvild; Hansson, Vidar; Tasken, Kjetil; Frøland, Stig Sophus & Muller, Fredrik (1999). Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency. Journal of Immunology.  ISSN 0022-1767.  162(2), s 1178- 1185
  • Hansson, Vidar; Skålhegg, Bjørn Steen & Tasken, Kjetil (1999). Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  69(1-6), s 367- 378 Vis sammendrag
  • Skålhegg, Bjørn Steen; Landmark, Brynjar Fowels; Keryer, Guy; Hansson, Vidar; Jahnsen, Tore & Tasken, Kjetil (1999). Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area. Experimental Cell Research.  ISSN 0014-4827.  249(1), s 131- 146 Vis sammendrag
  • Skålhegg, Bjørn Steen; Witczak, Oliwia; Reinton, Nils Torgny Kjelkevik; Eide, Turid; Eikvar, Sissel; Collas, Philippe; Tasken, Kjetil; Jahnsen, Tore & Ørstavik, Sigurd (1999). Specific effects of cAMP are mediated by multiple isozymes of cyclic AMP-dependent protein kinase and A-kinase anchoring proteins. Journal of Molecular Microbiology and Biotechnology.  ISSN 1464-1801.  1, s 49- 63 Vis sammendrag
  • Witczak, Oliwia; Skålhegg, Bjørn Steen; Keryer, Guy; Bornens, Michel; Tasken, Kjetil; Jahnsen, Tore & Ørstavik, Sigurd (1999). Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO Journal.  ISSN 0261-4189.  18(7), s 1858- 1868 Vis sammendrag
  • Aandahl, Einar Martin; Aukrust, Pål; Skålhegg, Bjørn Steen; Muller, Fredrik; Frøland, Stig Sophus; Hansson, Vidar & Tasken, Kjetil (1998). Protein kinase type I antagonist restores immune responses of T-cells from HIV-infected patients. The FASEB Journal.  ISSN 0892-6638.  12, s 855- 862
  • Andersson, Kristin Brevik & Skålhegg, Bjørn Steen (1998). Genetisk skreddersøm av mus. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  118, s 3952- 3957
  • Eide, Turid; Coglan, V.; Ørstavik, Sigurd; Holsve, Christian; Solberg, Rigmor; Skålhegg, Bjørn Steen; Lamb, N.J.C.; Langeberg, L.; Fernandez, Alicia; Scott, John D.; Jahnsen, Tore & Tasken, Kjetil (1998). Molecular Cloning, Chromosomal Localization and Cell Cycle-Dependent Subcellular Distribution of the A-kinase anchoring protein, AKAP95. Experimental Cell Research.  ISSN 0014-4827.  (238), s 305- 316

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  • Skålhegg, Bjørn Steen (2012). Mat og Medisin. Kapittel 8, Protein. Cappelen Damm Akademisk.  ISBN 978-82-7634-967-2.  12 s.
  • Skålhegg, Bjørn Steen & Refsum, Helga (2012). Mat og Medisin. Kapittel 11, B-vitaminer. Cappelen Damm Akademisk.  ISBN 978-82-7634-967-2.  18 s.

Se alle arbeider i Cristin

Se alle arbeider i Cristin

Publisert 13. apr. 2011 10:40 - Sist endret 11. des. 2017 15:26