Jala Imad

• Osen, Kirsten Kjelsberg; Imad, Jala; Wennberg, Arvind Eirik; Papp, Eszter Agnes & Leergaard, Trygve Brauns (2019). Waxholm Space atlas of the rat brain auditory system: Three-dimensional delineations based on structural and diffusion magnetic resonance imaging. NeuroImage. ISSN 1053-8119. 199, s. 38–56. doi: 10.1016/j.neuroimage.2019.05.016. Fulltekst i vitenarkiv Vis sammendrag

  The mammalian auditory system comprises a complex network of brain regions. Interpretations and comparisons of experimental results from this system depend on appropriate anatomical identification of auditory structures. The Waxholm Space (WHS) atlas of the Sprague Dawley rat brain (Papp et al., Neuroimage 97:374-86, 2014) is an open access, three-dimensional reference atlas defined in an ex-vivo magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) volume. Version 2.0 of the atlas (Kjonigsen et al., Neuroimage 108:441-9, 2015) includes detailed delineations of the hippocampus and several major subcortical regions, but only few auditory structures. To amend this, we have delineated the complete ascending auditory system from the cochlea to the cerebral cortex. 40 new brain structure delineations have been added, and the delineations of 10 regions have been revised based on the interpretation of image features in the WHS rat brain MRI/DTI volumes. We here describe and validate the new delineations in relation to corresponding cell- and myelin-stained histological sections and previous literature. We found it possible to delineate all main regions and the majority of subregions and fibre tracts of the ascending auditory pathway, apart from the auditory cortex, for which delineations were extrapolated from a conventional two-dimensional atlas. By contrast, only parts of the descending pathways were discernible in the template. Version 3.0 of the atlas, with altogether 118 anatomical delineations, is shared via the NeuroImaging Tools and Resources Collaboratory (www.nitrc.org).

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• Bjerke, Ingvild Elise; Imad, Jala; Clascá, Francisco; Groenewegen, Henk J.; Bjaalie, Jan G. & Leergaard, Trygve Brauns (2022). Waxholm Space atlas of the Sprague Dawley rat brain version 4: A volumetric atlas enabling data integration and analysis.
• Imad, Jala; Kleven, Heidi; Clascá, Francisco; Wennberg, Arvind Eirik; Osen, Kirsten Kjelsberg & Coello, Sebastian Christopher [Vis alle 11 forfattere av denne artikkelen] (2017). Enriching and adding detail to the Waxholm Space rat brain reference atlas.
• Imad, Jala; Osen, Kirsten Kjelsberg; Clascá, Francisco; Wennberg, Arvind E.; Coello, Sebastian Christopher & Csúcs, Gergely [Vis alle 9 forfattere av denne artikkelen] (2017). Enriching and Adding Detail to the Waxholm Space Rat Brain Reference Atlas. Vis sammendrag

  Brain reference atlases are important resources for assigning anatomical location to experimental data, and for planning and interpreting experimental results. Three-dimensional atlases can also serve as templates for spatial co-registration (integration) and comparison of different types of brain images. The Waxholm Space atlas of the rat brain is a public resource based on high resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data. It features a coordinate system based on internal landmarks (Waxholm Space) and delineations of so far 79 brain structures (Papp et al., Neuroimage 97:374-386, 2015; Kjonigsen et al., Neuroimage 108:441-449, 2015). The atlas is shared via the Neuroimaging Informatics Tools and Resources Clearinghouse (www.nitrc.org), and has since its release been widely adopted by the community. A limitation is, however, that detailed anatomical delineations of several major brain regions are missing. In some instances, delineations are not easily introduced due to low contrast in the underlying MRI / DTI templates, or complex features that are challenging to interpret in MRI / DTI data. To amend this, we have spatially registered images of serial histological sections stained for cyto-, chemo- and myeloarchitecture to the Waxholm Space rat brain template, and used these to aid the interpretation of boundaries of structures. We here outline our approach to defining brain structures in the Waxholm Space rat brain template, and present new delineations of the ascending auditory system, the thalamus, as well as several regions in the cerebral cortex and basal forebrain. The anatomical criteria underlying the delineations will be published, and the next version of the atlas delineations will be shared from www.nitrc.org.

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