Ageing is a fundamental attributor to a variety of human pathologies, such as frailty, cancer, and many neurodegenerative diseases including Alzheimer’s disease.
The global elderly population is projected to substantially increase in this century; by the year 2100, 25% of the world population will be over 65 years old. This represents an international concern because of the severe socioeconomic and healthcare challenges associated with ageing.
We are fascinated with exploring the basic molecular mechanisms of human ageing and age-related diseases, with a final goal to develop interventional strategies to improve people's lifespan and healthspan.
There are three major research interests in my Laboratory, including 1) NAD+ and aging; 2) Molecular mechanisms of mitophagy and its protective roles in Alzheimer's disease; and 3) The application of artificial intelligance on drug development for Alzheimer's disease and healthy longevity.
The group possesses a vast knowledge of aging and can attack from many sides with a number of international partners. This interdisciplinary strategy allows us to work broadly, gain more knowledge and achieve fruitful results.