Fei Fang

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Phone +47 67963923
Mobile phone +47-92230968
Room B103.081
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Visiting address Epi-Gen Akershus University Hospital
Postal address Akershus universitetssykehus 1478 LØRENSKOG

Ageing is a fundamental attributor to a variety of human pathologies, such as frailty, cancer, and many neurodegenerative diseases including Alzheimer’s disease.

The global elderly population is projected to substantially increase in this century; by the year 2100, 25% of the world population will be over 65 years old. This represents an international concern because of the severe socioeconomic and healthcare challenges associated with ageing. 

We are fascinated with exploring the basic molecular mechanisms of human ageing and age-related diseases, with a final goal to develop interventional strategies to improve people's lifespan and healthspan. 

There are three major research interests in my Laboratory, including 1) NAD+ and aging; 2) Molecular mechanisms of mitophagy and its protective roles in Alzheimer's disease; and 3) The application of artificial intelligance on drug development for Alzheimer's disease and healthy longevity.

The group possesses a vast knowledge of aging and can attack from many sides with a number of international partners. This interdisciplinary strategy allows us to work broadly, gain more knowledge and achieve fruitful results.

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Publications

  • Fang EF, Scheibye-Knudsen M, Brace L, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA (2014). Defective Mitophagy in XPA via PARP1 hyperactivation and NAD+/SIRT1 reduction, Cell, 157 (4): 882-896. This paper offers first evidence that compromised mitophagy exacerbates accelerated aging
  • Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA (2016). NAD+ replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair, Cell Metabolism, 24, 566-581. This feature article of the issue describes NAD+ induces mitophagy through DCT-1
  • Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA. In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice, JOVE, 2017, In press. This method paper summarizes mitophagy detection methods in cross-species model systems
  • Fang EF, Scheibye-Knudsen M, Chua KF, Mattson MP, Croteau DL, Bohr VA (2016). Nuclear DNA damage signalling to mitochondria in ageing, Nature Rev Mol Cell Bio, 17(5):308-321. This review paper proposes a novel concept to the aging theory
  • Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA. NAD+ in aging: Molecular mechanisms and translational implicationis. Trends Mol Med. 2017, in press. This Feature review summarizes latest progress of NAD+ in aging, and suggests compromised autophagy as the 10th hall marker of aging.   
  • Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA*, Fang EF*. Mitophagy and Alzheimer’s disease: Cellular and molecular mechanisms, Trends in Neurosciences, 40(3):151-166 (*Corresponding author). This review proposes compromised mitophagy as a new concept in AD etiology.
  •    Fang EF*, Hou Y, Palikaras K, et al, Mattson MP, Tavernarakis N, Bohr VA*. ­­Mitophagy inhibits Aβ and p-Tau pathologies and cognitive deficits in experimental models of Alzheimer’s disease. Nature Neuroscience, 2019, 22(3):401-412 (* corresponding author).Highlighted in Nature Reviews Drug Discovery ;     News in VG (the largest newspaper in Norway, 12 Feb 2019 Issue );   News in NRKHighlighted in ALZFORUM ; University of CopenhagenNational Institute on Ageing ; ScienceNordic;  NHI news;   NHI Facebook
  • Lautrup S, Sinclair DA, Mattson MP, Fang EF*. NAD+ in Brain Aging and Neurodegenerative Disorders. Cell Metabolism, 2019.
  • Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie; Aman, Yahyah; Røsjø, Helge; Brenner, Charles; Ziegler, Mathias; Tysnes, Ole-Bjørn; Tzoulis, Charalampos; Omland, Torbjørn; Søraas, Arne Vasli; Holmøy, Trygve; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Nilsen, Hilde & Fang, Evandro Fei (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development.  ISSN 0047-6374.  186:111208, s 1- 6 . doi: 10.1016/j.mad.2020.111208 Full text in Research Archive.
  • Okur, Mustafa Nazir; Fang, Evandro Fei; Fivenson, Elayne M.; Tiwari, Vinod; Croteau, Deborah L. & Bohr, Vilhelm A. (2020). Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling. Aging Cell.  ISSN 1474-9718. . doi: 10.1111/acel.13268
  • Wong, Jack Ho; Bao, Hui; Ng, Tzi Bun; Chan, Helen Hei Ling; Ng, Charlene Cheuk Wing; Man, Gene Chi Wai; Wang, Hexiang; Guan, Suzhen; Zhao, Shuang; Fang, Evandro Fei; Rolka, Krzysztof; Liu, Qin; Li, Chunman; Sha, Ou & Xia, Lixin (2020). New ribosome-inactivating proteins and other proteins with protein synthesis-inhibiting activities. Applied Microbiology and Biotechnology.  ISSN 0175-7598.  s 1- 16 . doi: 10.1007/s00253-020-10457-7
  • Wong, Jack Ho; Ng, Tzi Bun; Chan, Helen Hei Ling; Liu, Qin; Man, Gene Chi Wai; Zhang, Chris Zhiyi; Guan, Suzhen; Ng, Charlene Cheuk Wing; Fang, Evandro Fei; Wang, Hexiang; Liu, Fang; Ye, Xiuyun; Rolka, Krzysztof; Naude, Ryno; Zhao, Shuang; Sha, Ou; Li, Chunman & Xia, Lixin (2020). Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Applied Microbiology and Biotechnology.  ISSN 0175-7598.  s 1- 29 . doi: 10.1007/s00253-020-10476-4
  • Xie, Chenglong; Aman, Yahyah; Adriaanse, Bryan A.; Cader, M. Zameel; Plun-Favreau, Hélène; Xiao, Jian & Fang, Evandro Fei (2020). Culprit or Bystander: Defective Mitophagy in Alzheimer?s Disease. Frontiers in Cell and Developmental Biology.  ISSN 2296-634X.  7:391, s 1- 9 . doi: 10.3389/fcell.2019.00391 Full text in Research Archive.
  • Aman, Yahyah; Johannessen, Frank; Lautrup, Sofie Hindkjær; Matysek, Adrian; Niu, Zhangming; Yang, Guang; Shi, Liu; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Rasmussen, Lene Mydland; Bohr, Vilhelm; Nilsen, Hilde & Fang, Evandro Fei (2020). The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications. Mechanisms of Ageing and Development.  ISSN 0047-6374.  185, s 1- 11 . doi: 10.1016/j.mad.2019.111194
  • Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Fei & Kainov, Denis (2020). Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers.  ISSN 2072-6694.  12(6), s 1- 19 . doi: 10.3390/cancers12061694 Full text in Research Archive.
  • Fang, Evandro Fei; Hou, Yujun; Hindkjær Lautrup, Sofie; Jensen, Martin Borch; Yang, Beimeng; Sengupta, Tanima; Caponio, Domenica; Khezri, Rojyar; Demarest, Tyler G.; Aman, Yahyah; Figueroa, David; Morevati, Marya; Lee, Ho-Joon; Kato, Hisaya; Kassahun, Henok; Lee, Jong-Hyuk; Filippelli, Deborah; Okur, Mustafa Nazir; Mangerich, Aswin; Croteau, Deborah L.; Maezawa, Yoshiro; Lyssiotis, Costas A.; Tao, Jun; Yokoto, Koutaro; Rusten, Tor Erik; Mattson, Mark P.; Jasper, Heinrich; Nilsen, Hilde Loge & Bohr, Vilhelm A. (2019). NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.. Nature Communications.  ISSN 2041-1723.  10:5284, s 1- 18 . doi: 10.1038/s41467-019-13172-8 Full text in Research Archive.
  • Fang, Evandro Fei; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A.; Kerr, Jesse S.; Yang, Beimeng; Hindkjær Lautrup, Sofie; Hasan-Olive, Md Mahdi; Caponio, Domenica; Dan, Xiuli; Rocktäschel, Paula; Croteau, Deborah L.; Akbari, Mansour; Greig, Nigel H.; Fladby, Tormod; Nilsen, Hilde; Cader, M. Zameel; Mattson, Mark P.; Tavernarakis, Nektarios & Bohr, Vilhelm A. (2019). Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature Neuroscience.  ISSN 1097-6256.  22(3), s 401- 412 . doi: 10.1038/s41593-018-0332-9 Full text in Research Archive.
  • Hindkjær Lautrup, Sofie; Caponio, Domenica; Cheung, Hoi-Hung; Piccoli, Claudia; Stevnsner, Tinna; Chan, Wai-Yee & Fang, Evandro Fei (2019). Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. Biogerontology (Dordrecht).  ISSN 1389-5729.  20, s 1- 15 . doi: 10.1007/s10522-019-09798-2 Full text in Research Archive.
  • Hindkjær Lautrup, Sofie; Sinclair, David A.; Mattson, Mark P. & Fang, Evandro Fei (2019). NAD+ in brain aging and neurodegenerative disorders. Cell Metabolism.  ISSN 1550-4131.  s 1- 26 . doi: 10.1016/j.cmet.2019.09.001 Full text in Research Archive.
  • Hu, Wei; Zhang, Lin; Li, Ming Xing; Shen, Jing; Liu, Xiao Dong; Xiao, Zhan Gang; Wu, Ding Lan; Ho, Idy H. T.; Wu, Justin C. Y.; Cheung, Cynthia K. Y.; Zhang, Yu Chen; Lau, Alaster H. Y.; Ashktorab, Hassan; Smoot, Duane T.; Fang, Evandro Fei; Chan, Matthew T. V.; Gin, Tony; Gong, Wei; Wu, William K. K. & Cho, Chi Hin (2019). Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Autophagy.  ISSN 1554-8627.  15(4), s 707- 725 . doi: 10.1080/15548627.2018.1557835 Full text in Research Archive.
  • Lou, Guofeng; Palikaras, Konstantinos; Hindkjær Lautrup, Sofie; Scheibye-Knudsen, Morten; Tavernarakis, Nektarios & Fang, Evandro Fei (2019). Mitophagy and neuroprotection. Trends in Molecular Medicine.  ISSN 1471-4914.  s 1- 13 . doi: 10.1016/j.molmed.2019.07.002 Full text in Research Archive.
  • Waltz, Tyler B.; Fivenson, Elayne M.; Morevati, Marya; Li, Chuanhao; Becker, Kevin G.; Bohr, Vilhelm A. & Fang, Evandro Fei (2018). Sarcopenia, Aging and Prospective Interventional Strategies. Current Medicinal Chemistry.  ISSN 0929-8673.  25(40), s 5588- 5596 . doi: 10.2174/0929867324666170801095850
  • Aman, Yahyah; Qiu, Yuming; Tao, Jun & Fang, Fei (2018). Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging.  ISSN 2468-5011. . doi: 10.1016/j.tma.2018.08.003
  • Fang, Evandro Fei; Lautrup, Sofie; Hou, Yujun; Demarest, Tyler G.; Croteau, Deborah L.; Mattson, Mark P. & Bohr, Vilhelm A. (2017). NAD+ in aging: molecular mechanisms and translational implications. Trends in Molecular Medicine.  ISSN 1471-4914.  23(10), s 899- 916 . doi: 10.1016/j.molmed.2017.08.001
  • Fang, Evandro Fei; Waltz, Tyler B.; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S.; Morevati, Marya; Fivenson, Elayne M.; Wollman, Bradley N.; Marosi, Krisztina; Wilson, Mark A.; Iser, Wendy B.; Mark Eckley, D; Zhang, Yongqing; Lehrmann, Elin; Goldberg, Ilya G; Scheibye-Knudsen, Morten; Mattson, Mark P; Nilsen, Hilde Loge; Bohr, Vilhelm A. & Becker, Kevin G (2017). Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep46208 Full text in Research Archive.
  • Fivenson, Elayne M.; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna; Nilsen, Hilde Loge; Bohr, Vilhelm A. & Fang, Evandro Fei (2017). Mitophagy in neurodegeneration and aging. Neurochemistry International.  ISSN 0197-0186.  109, s 202- 209 . doi: 10.1016/j.neuint.2017.02.007 Full text in Research Archive.
  • Fang, Evandro Fei; Palikaras, Konstantinos; Sun, Nuo; Fivenson, Elayne M.; Spangler, Ryan D.; Kerr, Jesse S.; Cordonnier, Stephanie A.; Hou, Yujun; Dombi, Eszter; Kassahun, Henok; Tavernarakis, Nektarios; Poulton, Joanna; Nilsen, Hilde Loge & Bohr, Vilhelm A. (2017). In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. Journal of Visualized Experiments.  ISSN 1940-087X.  2017(129) . doi: 10.3791/56301
  • Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L.; Scheibye-Knudsen, Morten; Marosi, Krisztina; Lu, Huiming; Shamanna, Raghavendra A.; Kalyanasundaram, Sumana; Bollineni, Ravi Chand; Wilson, Mark A.; Iser, Wendy B.; Wollman, Bradley N.; Morevati, Marya; Li, Jun; Kerr, Jesse S.; Lu, Qiping; Waltz, Tyler B.; Tian, Jane; Sinclair, David A.; Mattson, Mark P.; Nilsen, Hilde & Bohr, Vilhelm A. (2016). NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism.  ISSN 1550-4131.  24(4), s 566- 581 . doi: 10.1016/j.cmet.2016.09.004
  • Scheibye-Knudsen, Morten; Tseng, Anne; Jensen, Martin Borch; Scheibye-Alsing, Karsten; Fang, Evandro Fei; Iyama, Teruaki; Bharti, Sanjay Kumar; Marosi, Krisztina; Froetscher, Lynn; Kassahun, Henok; Eckley, David Mark; Maul, Robert W; Bastian, Paul; De, Supriyo; Ghosh, Soumita; Nilsen, Hilde; Goldberg, Ilya G; Mattson, Mark P.; Wilson, David M.; Brosh, Robert M; Gorospe, Myriam & Bohr, Vilhelm A (2016). Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  113(44), s 12502- 12507 . doi: 10.1073/pnas.1610198113
  • Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima; Nilsen, Hilde; Mitchell, James R; Croteau, Deborah L & Bohr, Vilhelm A (2014). Defective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reduction. Cell.  ISSN 0092-8674.  157(4), s 882- 896 . doi: 10.1016/j.cell.2014.03.026
  • Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima; Nilsen, Hilde; Mitchell, James R; Croteau, Deborah L & Bohr, Vilhelm A. (2014). Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction. Cell.  ISSN 0092-8674.  157(4) . doi: 10.1016/j.cell.2014.03.026 Show summary

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  • Hindkjær Lautrup, Sofie; Lou, Guofeng; Aman, Yahyah; Nilsen, Hilde; Tao, Jun & Fang, Evandro Fei (2019). Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease. Neurochemistry International.  ISSN 0197-0186.  129 . doi: 10.1016/j.neuint.2019.104469
  • Fang, Evandro Fei (2018). The 54th Contact Meeting of the Norwegian Biochemical Society, Norway.
  • Fang, Fei (2018). DNA repair, NAD+, and mitophagy in life and health.
  • Fang, Fei (2018). Mitophagy and NAD+ in neuroprotection and longevity.
  • Fang, Fei (2018). Mitophagy in neuroprotection and healthy longevity.
  • Fang, Fei (2018). NAD+ and DNA repair in healthy longevity.
  • Fang, Fei (2018). NAD+ inhibits accelerated ageing in the Werner syndrome.
  • Fang, Fei (2018). NAD+, mitophagy, and DNA repair in ageing.
  • Fang, Fei (2018). The interconnected roles between DNA repair, NAD+, and mitophagy in ageing and neurodegeneration.
  • Gudmundsrud, Ruben; Lautrup, Sofie; Nilsen, Hilde Loge; Bohr, Vilhelm & Fang, Fei (2018). Mitofagi i nevrodegenerasjon og aldring. BestPractice Norge.  109, s 202- 209 . doi: 10.1016/j.neuint.2017.02.007

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Published Sep. 5, 2017 10:24 AM - Last modified Jan. 2, 2020 8:05 PM

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