Fei Fang

Bilde av Fei Fang
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Telefon +47 67963923
Mobiltelefon +47-92230968
Rom B103.081
Brukernavn
Besøksadresse Epi-Gen Akershus universitetssykehus
Postadresse Akershus universitetssykehus 1478 LØRENSKOG

Aldring er en fundamental prosess medvirkende til utvikling av en rekke sykdommer i mennesket, slik som skrøpelighet, kreft og flere nevrodegenerative sykdommer, inkludert Alzheimers sykdom.

Den globale populasjonen av eldre anslås å øke betydelig i dette århundret; innen år 2100 vil 25% av verdens befolkning være over 65 år gamle. Dette representerer en internasjonal bekymring på grunn av de alvorlige sosioøkonomiske og helsemessige utfordringene knyttet til aldring.

Vi fascineres av å utforske de grunnleggende molekylære mekanismene for menneskelig aldring og aldersrelatert sykdom, og har et endelig mål om å utvikle intervensjonsstrategier for å forbedre menneskers levetid og «healthspan» (den friske og aktive delen av livet.)

Det er tre store forskningsinteresser i min lab, dette inkluderer 1) NAD+ og aldring; 2) molekylære mekanismer for mitofagi; og 3) kompromittert mitofagi ved Alzheimers sykdom.

Gruppen besitter en enorm kunnskap om aldring, og kan med en rekke internasjonale samarbeidspartnere angripe fra mange kanter. Denne tverrfaglige strategien gjør at vi kan arbeide bredt, vinne mer kunnskap og oppnå fruktbare resultater.

 

Publikasjoner

  • Fang EF, Scheibye-Knudsen M, Brace L, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA (2014). Defective Mitophagy in XPA via PARP1 hyperactivation and NAD+/SIRT1 reduction, Cell, 157 (4): 882-896. This paper offers first evidence that compromised mitophagy exacerbates accelerated aging
  • Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA (2016). NAD+ replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair, Cell Metabolism, 24, 566-581. This feature article of the issue describes NAD+ induces mitophagy through DCT-1
  • Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA. In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice, JOVE, 2017. This method paper summarizes mitophagy detection methods in cross-species model systems
  • Fang EF, Scheibye-Knudsen M, Chua KF, Mattson MP, Croteau DL, Bohr VA (2016). Nuclear DNA damage signalling to mitochondria in ageing, Nature Rev Mol Cell Bio, 17(5):308-321. This review paper proposes a novel concept to the aging theory
  • Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA. NAD+ in aging: Molecular mechanisms and translational implicationis. Trends Mol Med. 2017, in press. This Feature review summarizes latest progress of NAD+ in aging, and suggests compromised autophagy as the 10th hall marker of aging.   
  • Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA*, Fang EF*. Mitophagy and Alzheimer’s disease: Cellular and molecular mechanisms, Trends in Neurosciences, 40(3):151-166 (*Corresponding author). This review proposes compromised mitophagy as a new concept in AD etiology.
  •  Fang EF*, Hou Y, Palikaras K, et al, Mattson MP, Tavernarakis N, Bohr VA*. Mitophagy inhibits Aβ and p-Tau pathologies and cognitive deficits in experimental models of Alzheimer’s disease. Nature Neuroscience, 2019, 22(3):401-412 (* corresponding author).Highlighted in Nature Reviews Drug Discovery ;     News in VG (the largest newspaper in Norway, 12 Feb 2019 Issue );   News in NRKHighlighted in ALZFORUM ; University of CopenhagenNational Institute on Ageing ; ScienceNordic;  NHI news;   NHI Facebook
  • Fang EF, Hou Y, Lautrup S. et al., NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nature Communications, 2019.Download; News in Forskning.no; News in the University of Oslo; News in the University of Copenhagen; Mailonline
  • Fang EF, Scheibye-Knudsen M, Jahn H, Li J, Ling L, Guo H, Zhu X, Preedy V, Lu H, Bohr VA, Chan WY, Liu Y, Ng TB (2015). A research agenda for aging in China in the 21st century. Ageing Res Rev.Download
  • Gilmour BC, Gudmundsrud R…Fang EF. Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development, 2020. Download
  • A full list of publications as well as to download key publications here https://evandrofanglab.com/publications/
  • Kobro-Flatmoen, Asgeir; Lagartos-Donate, Maria Jose; Aman, Yahyah; Edison, Paul; Witter, Menno & Fang, Fei (2021). Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy. Ageing Research Reviews.  ISSN 1568-1637.  67:101307, s 1- 17 . doi: 10.1016/j.arr.2021.101307 Fulltekst i vitenarkiv. Vis sammendrag
  • Okur, Mustafa Nazir; Fang, Evandro Fei; Fivenson, Elayne M.; Tiwari, Vinod; Croteau, Deborah L. & Bohr, Vilhelm A. (2020). Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling. Aging Cell.  ISSN 1474-9718. . doi: 10.1111/acel.13268 Fulltekst i vitenarkiv.
  • Wong, Jack Ho; Bao, Hui; Ng, Tzi Bun; Chan, Helen Hei Ling; Ng, Charlene Cheuk Wing; Man, Gene Chi Wai; Wang, Hexiang; Guan, Suzhen; Zhao, Shuang; Fang, Evandro Fei; Rolka, Krzysztof; Liu, Qin; Li, Chunman; Sha, Ou & Xia, Lixin (2020). New ribosome-inactivating proteins and other proteins with protein synthesis-inhibiting activities. Applied Microbiology and Biotechnology.  ISSN 0175-7598.  s 1- 16 . doi: 10.1007/s00253-020-10457-7 Fulltekst i vitenarkiv.
  • Wong, Jack Ho; Ng, Tzi Bun; Chan, Helen Hei Ling; Liu, Qin; Man, Gene Chi Wai; Zhang, Chris Zhiyi; Guan, Suzhen; Ng, Charlene Cheuk Wing; Fang, Evandro Fei; Wang, Hexiang; Liu, Fang; Ye, Xiuyun; Rolka, Krzysztof; Naude, Ryno; Zhao, Shuang; Sha, Ou; Li, Chunman & Xia, Lixin (2020). Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Applied Microbiology and Biotechnology.  ISSN 0175-7598.  s 1- 29 . doi: 10.1007/s00253-020-10476-4 Fulltekst i vitenarkiv.
  • Xie, Chenglong; Aman, Yahyah; Adriaanse, Bryan A.; Cader, M. Zameel; Plun-Favreau, Hélène; Xiao, Jian & Fang, Evandro Fei (2020). Culprit or Bystander: Defective Mitophagy in Alzheimer?s Disease. Frontiers in Cell and Developmental Biology.  ISSN 2296-634X.  7:391, s 1- 9 . doi: 10.3389/fcell.2019.00391 Fulltekst i vitenarkiv.
  • Aman, Yahyah; Frank, Johannes; Lautrup, Sofie Hindkjær; Matysek, Adrian; Niu, Zhangming; Yang, Guang; Shi, Liu; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Rasmussen, Lene Mydland; Bohr, Vilhelm; Nilsen, Hilde & Fang, Evandro Fei (2020). The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications. Mechanisms of Ageing and Development.  ISSN 0047-6374.  185, s 1- 11 . doi: 10.1016/j.mad.2019.111194 Fulltekst i vitenarkiv.
  • Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie; Aman, Yahyah; Røsjø, Helge; Brenner, Charles; Ziegler, Mathias; Tysnes, Ole-Bjørn; Tzoulis, Charalampos; Omland, Torbjørn; Søraas, Arne Vasli; Holmøy, Trygve; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Nilsen, Hilde & Fang, Evandro Fei (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development.  ISSN 0047-6374.  186, s 1- 6 . doi: 10.1016/j.mad.2020.111208 Fulltekst i vitenarkiv.
  • Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Fei & Kainov, Denis (2020). Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers.  ISSN 2072-6694.  12(6), s 1- 19 . doi: 10.3390/cancers12061694 Fulltekst i vitenarkiv.
  • Fang, Evandro Fei; Hou, Yujun; Hindkjær Lautrup, Sofie; Jensen, Martin Borch; Yang, Beimeng; Sengupta, Tanima; Caponio, Domenica; Khezri, Rojyar; Demarest, Tyler G.; Aman, Yahyah; Figueroa, David; Morevati, Marya; Lee, Ho-Joon; Kato, Hisaya; Kassahun, Henok; Lee, Jong-Hyuk; Filippelli, Deborah; Okur, Mustafa Nazir; Mangerich, Aswin; Croteau, Deborah L.; Maezawa, Yoshiro; Lyssiotis, Costas A.; Tao, Jun; Yokoto, Koutaro; Rusten, Tor Erik; Mattson, Mark P.; Jasper, Heinrich; Nilsen, Hilde Loge & Bohr, Vilhelm A. (2019). NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.. Nature Communications.  ISSN 2041-1723.  10:5284, s 1- 18 . doi: 10.1038/s41467-019-13172-8 Fulltekst i vitenarkiv.
  • Fang, Evandro Fei; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A.; Kerr, Jesse S.; Yang, Beimeng; Hindkjær Lautrup, Sofie; Hasan-Olive, Md Mahdi; Caponio, Domenica; Dan, Xiuli; Rocktäschel, Paula; Croteau, Deborah L.; Akbari, Mansour; Greig, Nigel H.; Fladby, Tormod; Nilsen, Hilde; Cader, M. Zameel; Mattson, Mark P.; Tavernarakis, Nektarios & Bohr, Vilhelm A. (2019). Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature Neuroscience.  ISSN 1097-6256.  22(3), s 401- 412 . doi: 10.1038/s41593-018-0332-9 Fulltekst i vitenarkiv.
  • Hindkjær Lautrup, Sofie; Caponio, Domenica; Cheung, Hoi-Hung; Piccoli, Claudia; Stevnsner, Tinna; Chan, Wai-Yee & Fang, Evandro Fei (2019). Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. Biogerontology (Dordrecht).  ISSN 1389-5729.  20, s 1- 15 . doi: 10.1007/s10522-019-09798-2 Fulltekst i vitenarkiv.
  • Hindkjær Lautrup, Sofie; Sinclair, David A.; Mattson, Mark P. & Fang, Evandro Fei (2019). NAD+ in brain aging and neurodegenerative disorders. Cell Metabolism.  ISSN 1550-4131.  s 1- 26 . doi: 10.1016/j.cmet.2019.09.001 Fulltekst i vitenarkiv.
  • Hu, Wei; Zhang, Lin; Li, Ming Xing; Shen, Jing; Liu, Xiao Dong; Xiao, Zhan Gang; Wu, Ding Lan; Ho, Idy H. T.; Wu, Justin C. Y.; Cheung, Cynthia K. Y.; Zhang, Yu Chen; Lau, Alaster H. Y.; Ashktorab, Hassan; Smoot, Duane T.; Fang, Evandro Fei; Chan, Matthew T. V.; Gin, Tony; Gong, Wei; Wu, William K. K. & Cho, Chi Hin (2019). Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Autophagy.  ISSN 1554-8627.  15(4), s 707- 725 . doi: 10.1080/15548627.2018.1557835 Fulltekst i vitenarkiv.
  • Lou, Guofeng; Palikaras, Konstantinos; Hindkjær Lautrup, Sofie; Scheibye-Knudsen, Morten; Tavernarakis, Nektarios & Fang, Evandro Fei (2019). Mitophagy and neuroprotection. Trends in Molecular Medicine.  ISSN 1471-4914.  s 1- 13 . doi: 10.1016/j.molmed.2019.07.002 Fulltekst i vitenarkiv.
  • Lei, Wen; Xu, Yudai; Su, Jun; Chong, Cheong-Meng; Su, Huan-Xing; Luo, Junhong; Fang, Fei; Bao, Zhijun & Chen, Guobing (2019). Applications of high-throughput ‘omics’ data in the study of frailty. Translational Medicine of Aging.  ISSN 2468-5011.  3, s 40- 51 . doi: 10.1016/j.tma.2019.04.002
  • Waltz, Tyler B.; Fivenson, Elayne M.; Morevati, Marya; Li, Chuanhao; Becker, Kevin G.; Bohr, Vilhelm A. & Fang, Evandro Fei (2018). Sarcopenia, Aging and Prospective Interventional Strategies. Current Medicinal Chemistry.  ISSN 0929-8673.  25(40), s 5588- 5596 . doi: 10.2174/0929867324666170801095850
  • Aman, Yahyah; Qiu, Yuming; Tao, Jun & Fang, Fei (2018). Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging.  ISSN 2468-5011. . doi: 10.1016/j.tma.2018.08.003
  • Fang, Evandro Fei; Lautrup, Sofie; Hou, Yujun; Demarest, Tyler G.; Croteau, Deborah L.; Mattson, Mark P. & Bohr, Vilhelm A. (2017). NAD+ in aging: molecular mechanisms and translational implications. Trends in Molecular Medicine.  ISSN 1471-4914.  23(10), s 899- 916 . doi: 10.1016/j.molmed.2017.08.001
  • Fang, Evandro Fei; Waltz, Tyler B.; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S.; Morevati, Marya; Fivenson, Elayne M.; Wollman, Bradley N.; Marosi, Krisztina; Wilson, Mark A.; Iser, Wendy B.; Mark Eckley, D; Zhang, Yongqing; Lehrmann, Elin; Goldberg, Ilya G; Scheibye-Knudsen, Morten; Mattson, Mark P; Nilsen, Hilde Loge; Bohr, Vilhelm A. & Becker, Kevin G (2017). Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep46208 Fulltekst i vitenarkiv.
  • Fivenson, Elayne M.; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna; Nilsen, Hilde Loge; Bohr, Vilhelm A. & Fang, Evandro Fei (2017). Mitophagy in neurodegeneration and aging. Neurochemistry International.  ISSN 0197-0186.  109, s 202- 209 . doi: 10.1016/j.neuint.2017.02.007 Fulltekst i vitenarkiv.
  • Fang, Evandro Fei; Palikaras, Konstantinos; Sun, Nuo; Fivenson, Elayne M.; Spangler, Ryan D.; Kerr, Jesse S.; Cordonnier, Stephanie A.; Hou, Yujun; Dombi, Eszter; Kassahun, Henok; Tavernarakis, Nektarios; Poulton, Joanna; Nilsen, Hilde Loge & Bohr, Vilhelm A. (2017). In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. Journal of Visualized Experiments.  ISSN 1940-087X.  2017(129) . doi: 10.3791/56301
  • Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L.; Scheibye-Knudsen, Morten; Marosi, Krisztina; Lu, Huiming; Shamanna, Raghavendra A.; Kalyanasundaram, Sumana; Bollineni, Ravi Chand; Wilson, Mark A.; Iser, Wendy B.; Wollman, Bradley N.; Morevati, Marya; Li, Jun; Kerr, Jesse S.; Lu, Qiping; Waltz, Tyler B.; Tian, Jane; Sinclair, David A.; Mattson, Mark P.; Nilsen, Hilde & Bohr, Vilhelm A. (2016). NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism.  ISSN 1550-4131.  24(4), s 566- 581 . doi: 10.1016/j.cmet.2016.09.004
  • Scheibye-Knudsen, Morten; Tseng, Anne; Jensen, Martin Borch; Scheibye-Alsing, Karsten; Fang, Evandro Fei; Iyama, Teruaki; Bharti, Sanjay Kumar; Marosi, Krisztina; Froetscher, Lynn; Kassahun, Henok; Eckley, David Mark; Maul, Robert W; Bastian, Paul; De, Supriyo; Ghosh, Soumita; Nilsen, Hilde; Goldberg, Ilya G; Mattson, Mark P.; Wilson, David M.; Brosh, Robert M; Gorospe, Myriam & Bohr, Vilhelm A (2016). Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  113(44), s 12502- 12507 . doi: 10.1073/pnas.1610198113
  • Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima; Nilsen, Hilde; Mitchell, James R; Croteau, Deborah L & Bohr, Vilhelm A (2014). Defective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reduction. Cell.  ISSN 0092-8674.  157(4), s 882- 896 . doi: 10.1016/j.cell.2014.03.026
  • Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima; Nilsen, Hilde; Mitchell, James R; Croteau, Deborah L & Bohr, Vilhelm A. (2014). Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction. Cell.  ISSN 0092-8674.  157(4) . doi: 10.1016/j.cell.2014.03.026 Vis sammendrag

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  • Aman, Yahyah; Ryan, B; Torsetnes, Silje Bøen; Knapskog, Anne Brita; Watne, Leiv; McEwan, W & Fang, Fei (2020). Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases. International review of neurobiology.  ISSN 0074-7742.  155 . doi: 10.1016/bs.irn.2020.02.008
  • Hindkjær Lautrup, Sofie; Lou, Guofeng; Aman, Yahyah; Nilsen, Hilde; Tao, Jun & Fang, Evandro Fei (2019). Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease. Neurochemistry International.  ISSN 0197-0186.  129 . doi: 10.1016/j.neuint.2019.104469
  • Fang, Evandro Fei (2018). The 54th Contact Meeting of the Norwegian Biochemical Society, Norway.
  • Fang, Fei (2018). DNA repair, NAD+, and mitophagy in life and health.
  • Fang, Fei (2018). Mitophagy and NAD+ in neuroprotection and longevity.
  • Fang, Fei (2018). Mitophagy in neuroprotection and healthy longevity.
  • Fang, Fei (2018). NAD+ and DNA repair in healthy longevity.
  • Fang, Fei (2018). NAD+ inhibits accelerated ageing in the Werner syndrome.
  • Fang, Fei (2018). NAD+, mitophagy, and DNA repair in ageing.
  • Fang, Fei (2018). The interconnected roles between DNA repair, NAD+, and mitophagy in ageing and neurodegeneration.
  • Gudmundsrud, Ruben; Lautrup, Sofie; Nilsen, Hilde Loge; Bohr, Vilhelm & Fang, Fei (2018). Mitofagi i nevrodegenerasjon og aldring. BestPractice Norge.  109, s 202- 209 . doi: 10.1016/j.neuint.2017.02.007

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Publisert 5. sep. 2017 10:16 - Sist endret 3. feb. 2020 12:54