Jens Pahnke

• Leske, Henning; Rushing, Elisabeth; Budka, Herbert; Niehusmann, Pitt; Pahnke, Jens & Panagopoulos, Ioannis (2018). K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution. Acta Neuropathologica.  ISSN 0001-6322.  136, s 175- 176 . doi: 10.1007/s00401-018-1867-2
• Aleksis, Rihards; Oleskovs, Filips; Jaudzems, Kristaps; Pahnke, Jens & Biverstål, Henrik (2017). Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity. Biochimie.  ISSN 0300-9084.  140, s 176- 192 . doi: 10.1016/j.biochi.2017.07.011
• Sike, Adam; Wengenroth, Jonas; Upite, Jolanta; Brüning, Thomas; Eiriz Delgado, Iván; Santha, Petra; Biverstål, Henrik; Jansone, Baiba; Haugen, Håvard Jostein; Krohn, Markus & Pahnke, Jens (2017). Improved method for cannula fixation for long-term intracerebral brain infusion. Journal of Neuroscience Methods.  ISSN 0165-0270.  290, s 145- 150 . doi: 10.1016/j.jneumeth.2017.07.026
• Steffen, Johannes; Krohn, Markus; Schwitlick, christina; Brüning, Thomas; Paarmann, Kristin; Pietrzik, Claus U; Biverstål, Henrik; Jansone, Baiba; Langer, Oliver & Pahnke, Jens (2017). Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.. Acta neuropathologica communications.  ISSN 2051-5960.  5(1) . doi: 10.1186/s40478-017-0448-2
• Bernstein, Hans-Gert; Hildebrandt, Jens; Dobrowolny, Henrik; Steiner, J.; Bogerts, Bernhard & Pahnke, Jens (2016). Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula. Schizophrenia Research.  ISSN 0920-9964.  177(1-3), s 52- 58 . doi: 10.1016/j.schres.2016.02.036
• Hofrichter, Jacqueline; Krohn, Markus; Schumacher, Toni; Lange, Cathleen; Feistel, Björn; Walbroel, Bernd & Pahnke, Jens (2016). Sideritis spp. extracts enhance memory and learning in Alzheimer's β-amyloidosis mouse models and aged C57Bl/6 mice. Journal of Alzheimer's Disease.  ISSN 1387-2877.  53(3), s 967- 980 . doi: 10.3233/JAD-160301
• Marques, Fernanda; Sousa, Joao Carlos; Brito, Maria Alexandra; Pahnke, Jens; Santos, Cecilia; Correia-Neves, Margarida & Palha, Joana Almeida (2016). The choroid plexus in health and in disease: dialogues into and out of the brain. Neurobiology of Disease.  ISSN 0969-9961.  (107), s 32- 40 . doi: 10.1016/j.nbd.2016.08.011
• Möhle, Luisa; Israel, Nicole; Paarmann, Kristin; Krohn, Markus; Pietkiewicz, Sabine; Müller, Andreas; Lavrik, Inna N; Buguliskis, Jeffrey S; Schott, Björn H; Schlüter, Dirk; Gundelfinger, Eckart D; Montag, Dirk; Seifert, Ulrike; Pahnke, Jens & Dunay, Ildiko Rita (2016). Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta neuropathologica communications.  ISSN 2051-5960.  4 . doi: 10.1186/s40478-016-0293-8
• Steffen, Johannes; Krohn, Markus; Paarmann, Kristin; Schwitlick, christina; Brüning, Thomas; Marreiros, Rita; Müller-Schiffmann, Andreas; Korth, Carsten; Braun, Katharina & Pahnke, Jens (2016). Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta neuropathologica communications.  ISSN 2051-5960.  5(49) . doi: 10.1186/s40478-016-0363-y
• Apostolova, Ivayla; Niedzielska, Dagmara; Derlin, Thorsten; Koziolek, Eva J.; Amthauer, Holger; Salmen, Benedikt; Pahnke, Jens; Brenner, Winfried; Mautner, Victor F. & Buchert, Ralph (2015). Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: Towards a biomarker of neurologic deficits. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  35(8), s 1304- 1312 . doi: 10.1038/jcbfm.2015.43
• Budworth, Helen; Harris, Faye R.; Williams, Paul; Lee, Do Yup; Holt, Amy; Pahnke, Jens; Szczesny, Bartosz; McMurray, Cynthia T.; Acevedo-Torres, Karina & Ayala-Peña, Sylvette (2015). Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s disease. PLoS Genetics.  ISSN 1553-7390.  11:e1005267(8) . doi: 10.1371/journal.pgen.1005267
• Fröhlich, Christina; Zschiebsch, Katja; Gröger, Victoria; Paarmann, Kristin; Steffen, Johannes; Thurm, Christoph; Schropp, Eva-Maria; Brüning, Thomas; Gellerich, Frank; Radloff, Martin; Schwabe, Rainer; Lachmann, Ingolf; Krohn, Markus; Ibrahim, Saleh & Pahnke, Jens (2015). Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies. Molecular Neurobiology.  ISSN 0893-7648.  Published ahead of print . doi: 10.1007/s12035-015-9399-4 Show summary

  Parkinson ’ s disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most com- mon neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to en- hance clearance of amyloid- β from the brain of APP- transgenic mice leading to beneficial clinical outcome. It has been discussed whether sp ecific mitochondrial alter- ations contribute to disease p rogression or even prevent toxic peptide deposition, as seen in many neurodegener- ative diseases. Here, we investigated α -synuclein- transgenic C57BL/6J mice with the A30P mutation, and a novel A30P C57BL/6J mouse model with three mitochondrial DNA polymorphisms in the ND3, COX3 and mtRNA Arg genes, as found in the inbred NOD/LtJ mouse strain. We were able to detect that the new mod- el has increased mitochondrial complex II-respiration which occurs in parallel to neuronal loss and improved motor performance, although it exhibits higher amounts of high molecular weight species of α -synuclein. High molecular weight aggregates of different peptides are controversially discussed in the light of neurodegenera- tion. A favourable hypothesis states that high molecular weight species are protective and of minor importance for the pathogenesis of neurodegenerative disorders as compared to the extreme neurotoxic monomers and olig- omers. Summarising, our results point to a potentially protective and beneficial effect of specific mitochondrial polymorphisms which cause improved mitochondrial complex II-respiration in α -synucleinopathies, an effect that could be exploited further for pharmaceutical interventions.

• Krohn, Markus; Bracke, Alexander; Avchalumov, Yosef; Schumacher, Toni; Hofrichter, Jacqueline; Paarmann, Kristin; Fröhlich, Christina; Lange, Cathleen; Brüning, Thomas; Von Bohlen und Halbach, Oliver & Pahnke, Jens (2015). Accumulation of murine amyloid-β mimics early Alzheimer's disease. Brain.  ISSN 0006-8950.  138(8), s 2370- 2382 . doi: 10.1093/brain/awv137
• Lill, Christina M.; Rengmark, Aina Sylvia Haugen; Pihlstrøm, Lasse; Fogh, Isabella; Shatunov, Aleksey; Sleiman, Patrick M.; Wang, Li-San; Liu, Tian; Lassen, Christina F.; Meissner, Esther; Alexopoulos, Panos; Calvo, Andrea; Chio, Adriano; Dizdar, Nil; Faltraco, Frank; Forsgren, Lars; Kirchheiner, Julia; Kurz, Alexander; Larsen, Jan Petter; Liebsch, Maria; Linder, Jan; Morrison, Karen E; Nissbrandt, Hans; Otto, Markus; Pahnke, Jens; Partch, Amanda; Restagno, Gabriella; Rujescu, Dan; Schnack, Cathrin; Shaw, Christopher E.; Shaw, Pamela J.; Tumani, Hayrettin; Tysnes, Ole-Bjørn; Valladares, Otto; Silani, Vincenzo; van den Berg, Leonard H.; Van Rheenen, Wouter; Veldink, Jan H.; Lindenberger, Ulman; Steinhagen-Thiessen, Elisabeth; Teipel, Stefan; Perneczky, Robert; Hakonarson, Hakon; Hampel, Harald; Von Arnim, Christine A.F.; Olsen, Jørgen H.; Van Deerlin, Vivianna M.; Al-Chalabi, Ammar; Toft, Mathias; Ritz, Beate & Bertram, Lars (2015). The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease. Alzheimer's & Dementia.  ISSN 1552-5260.  11(12), s 1407- 1416 . doi: 10.1016/j.jalz.2014.12.009
• Wanek, Thomas; Römermann, Kerstin; Mairinger, Severin; Stanek, Johann; Sauberer, Michael; Filip, Thomas; Traxl, Alexander; Kuntner, Claudia; Pahnke, Jens; Bauer, Florian; Erker, Thomas; Löscher, Wolfgang; Müller, Markus & Langer, Oliver (2015). Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with positron emission tomography. Molecular Pharmaceutics.  ISSN 1543-8384.  12(9), s 3214- 3225 . doi: 10.1021/acs.molpharmaceut.5b00168
• Bernstein, Hans-Gert; Hölzl, Gloria; Dobrowolny, Henrik; Hildebrandt, Jens; Trubner, Kurt; Krohn, Markus; Bogerts, Bernhard & Pahnke, Jens (2014). Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. Mechanisms of Ageing and Development.  ISSN 0047-6374.  141, s 12- 21 . doi: 10.1016/j.mad.2014.08.003
• Pahnke, Jens; Fröhlich, Christina; Paarmann, Kristin; Krohn, Markus; Bogdanovic, Nenad; Aarsland, Dag & Winblad, Bengt (2014). Cerebral ABC Transporter-common Mechanisms May Modulate Neurodegenerative Diseases and Depression in Elderly Subjects. Archives of Medical Research.  ISSN 0188-4409.  45(8), s 738- 743 . doi: 10.1016/j.arcmed.2014.10.010

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• Bernstein, Hans-Gert; Hildebrandt, J.; Dobrowolny, Henrik; Steiner, J.; Bogerts, Bernhard & Pahnke, Jens (2018). Corrigendum to ?Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula? [Schizophr. Res. 2016 Nov;177(1?3):52?58] (S0920996416300901) (10.1016/j.schres.2016.02.036)). Schizophrenia Research.  ISSN 0920-9964.  197, s 622- 623 . doi: 10.1016/j.schres.2018.03.036
• Jansone, Baiba; Pahnke, Jens & Biverstål, Henrik (2017). Alcheimera slimības izpētes aktualitātes. Latvijas ārsts.  ISSN 1019-5068.  s 48- 53
• Mairinger, Severin; Wanek, Thomas; Traxl, Alexander; Krohn, Markus; Stanek, Johann; Filip, Thomas; Sauberer, Michael; Kuntner, Claudia; Pahnke, Jens & Langer, Oliver (2016). 7-[11C]methyl-6-bromopurine, a PET tracer to measure brain Mrp1 function: radiosynthesis and first PET evaluation in mice. 32nd International Austrian Winter Symposium, Zell am See, the Netherlands. 20-23 January 2016. EJNMMI Research.  ISSN 2191-219X.  6(32) . doi: 10.1186/s13550-016-0168-9

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