Jens Pahnke

• Krohn, Markus; Zoufal, Viktoria; Mairinger, Severin; Wanek, Thomas; Paarmann, Kristin; Brüning, Thomas; Eiriz Delgado, Iván; Brackhan, Mirjam; Langer, Oliver & Pahnke, Jens (2019). Generation and characterization of an ABCC1 humanized mouse model (hABCC1(flx/flx) with knockout capability. Molecular Pharmacology.  ISSN 0026-895X.  96(2), s 138- 147 . doi: 10.1124/mol.119.115824
• Latysheva, Anna; Emblem, Kyrre Eeg; Brandal, Petter; Vik-Mo, Einar O.; Pahnke, Jens; Røysland, Kjetil; Hald, John K & Server, Andrés (2019). Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach. Neuroradiology.  ISSN 0028-3940.  61(5), s 545- 555 . doi: 10.1007/s00234-019-02173-5 Vis sammendrag

  Purpose According to the revised World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) of 2016, oligodendrogliomas are now defined primarily by a specific molecular signature (presence of IDH mutation and 1p19q codeletion). The purpose of our study was to assess the value of dynamic susceptibility contrast MR imaging (DSC-MRI) and diffusion-weighted imaging (DWI) to characterize oligodendrogliomas and to distinguish them from astrocytomas. Methods Seventy-one adult patients with untreated WHO grade II and grade III diffuse infiltrating gliomas and known 1p/19q codeletion status were retrospectively identified and analyzed using relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) maps based on whole-tumor volume histograms. The Mann-Whitney U test and logistic regression were used to assess the ability of rCBV and ADC to differentiate between oligodendrogliomas and astrocytomas both independently, but also related to the WHO grade. Prediction performance was evaluated in leave-one-out cross-validation (LOOCV). Results Oligodendrogliomas showed significantly higher microvascularity (higher rCBVMean ≥ 0.80, p = 0.013) and higher vascular heterogeneity (lower rCBVPeak ≤ 0.044, p = 0.015) than astrocytomas. Diffuse gliomas with higher cellular density (lower ADCMean ≤ 1094 × 10−6 mm2/s, p = 0.009) were more likely to be oligodendrogliomas than astrocytomas. Histogram analysis of rCBV and ADC was able to differentiate between diffuse astrocytomas (WHO grade II) and anaplastic astrocytomas (WHO grade III). Conclusion Histogram-derived rCBV and ADC parameter may be used as biomarkers for identification of oligodendrogliomas and may help characterize diffuse gliomas based upon their genetic characteristics. Keywords Diffuse glioma Perfusion MRI Diffusion MRI

• Zoufal, Viktoria; Mairinger, Severin; Krohn, Markus; Wanek, Thomas; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Kuntner, Claudia; Pahnke, Jens & Langer, Oliver (2019). Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  s 1- 12 . doi: 10.1177/0271678X19854541
• Ceafalan, Laura Cristina; Fertig, Tudor Emanuel; Gheorghe, Teodora Cristina; Hinescu, Mihail Eugen; Popescu, Bogdan Ovidiu; Pahnke, Jens & Gherghiceanu, Mihaela (2018). Age‐related ultrastructural changes of the basement membrane in the mouse blood‐brain barrier. Journal of Cellular and Molecular Medicine.  ISSN 1582-1838.  23(2), s 819- 827 . doi: 10.1111/jcmm.13980 Fulltekst i vitenarkiv.
• Chee, Yuemin Celina; Pahnke, Jens; Bunte, Ralph; Adsool, Vikrant A; Madan, Babita & Virshup, David M (2018). Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. Developmental Cell.  ISSN 1534-5807.  46(6), s 681- 695.e5 . doi: 10.1016/j.devcel.2018.07.023 Fulltekst i vitenarkiv.
• Krohn, Markus; Wanek, Thomas; Menet, Marie-Claude; Noack, Andreas; Declèves, Xavier; Langer, Oliver; Löscher, Wolfgang & Pahnke, Jens (2018). Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches. European Journal of Microbiology and Immunology.  ISSN 2062-509X.  8(3), s 78- 86 . doi: 10.1556/1886.2018.00008 Fulltekst i vitenarkiv.
• Lamartinière, Yordenca; Boucau, Marie-Christine; Dehouck, Lucie; Krohn, Markus; Pahnke, Jens; Candela, Pietra; Gosselet, Fabien & Fenart, Laurence (2018). ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier. Journal of Alzheimer's Disease.  ISSN 1387-2877.  64(4), s 1195- 1211 . doi: 10.3233/JAD-170883
• Latysheva, Anna; Emblem, Kyrre Eeg; Server, Andrés; Brandal, Petter; Meling, Torstein Ragnar; Pahnke, Jens & Hald, John K (2018). Survival associations using perfusion and diffusion magnetic resonance imaging in patients with histologic and genetic defined diffuse glioma World Health Organization grades II and III. Journal of computer assisted tomography.  ISSN 0363-8715.  42(5), s 807- 815 . doi: 10.1097/RCT.0000000000000742 Fulltekst i vitenarkiv.
• Leske, Henning; Rushing, Elisabeth; Budka, Herbert; Niehusmann, Pitt; Pahnke, Jens & Panagopoulos, Ioannis (2018). K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution. Acta Neuropathologica.  ISSN 0001-6322.  136, s 175- 176 . doi: 10.1007/s00401-018-1867-2
• Mairinger, Severin; Zoufal, Viktoria; Wanek, Thomas; Traxl, Alexander; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Kuntner, Claudia; Pahnke, Jens; Müller, Markus & Langer, Oliver (2018). Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice. European Journal of Pharmaceutical Sciences.  ISSN 0928-0987.  115, s 212- 222 . doi: 10.1016/j.ejps.2018.01.034
• Paarmann, Kristin; Prakash, Sanjeev; Krohn, Markus; Möhle, Luisa; Brackhan, Mirjam; Brüning, Thomas; Eiriz Delgado, Iván & Pahnke, Jens (2018). French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice. Phytomedicine.  ISSN 0944-7113.  57, s 39- 48 . doi: 10.1016/j.phymed.2018.11.033
• Steffen, Johannes; Stenzel, Jan; Ibrahim, Saleh & Pahnke, Jens (2018). Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease. Journal of Alzheimer's Disease.  ISSN 1387-2877.  65(2), s 465- 474 . doi: 10.3233/JAD-180395 Fulltekst i vitenarkiv.
• Storck, Steffen E.; Hartz, Anika M.S.; Bernard, Jessica; Wolf, Andreas; Kachlmeier, André; Mahringer, Anne; Weggen, Sascha; Pahnke, Jens & Pietrzik, Claus U. (2018). The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain, behavior, and immunity.  ISSN 0889-1591.  73, s 21- 33 . doi: 10.1016/j.bbi.2018.07.017
• Zoufal, Viktoria; Mairinger, Severin; Krohn, Markus; Wanek, Thomas; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Traxl, Alexander; Schuetz, John D; Kuntner, Claudia; Pahnke, Jens & Langer, Oliver (2018). Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[(11)C]Methylpurine in Mice. Molecular Imaging and Biology.  ISSN 1536-1632.  s 1- 11 . doi: 10.1007/s11307-018-1230-y Fulltekst i vitenarkiv.
• Zoufal, Viktoria; Wanek, Thomas; Krohn, Markus; Mairinger, Severin; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Pekar, Thomas; Bauer, Martin; Pahnke, Jens & Langer, Oliver (2018). Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X. . doi: 10.1177/0271678X18806640
• Aleksis, Rihards; Oleskovs, Filips; Jaudzems, Kristaps; Pahnke, Jens & Biverstål, Henrik (2017). Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity. Biochimie.  ISSN 0300-9084.  140, s 176- 192 . doi: 10.1016/j.biochi.2017.07.011
• Sike, Adam; Wengenroth, Jonas; Upite, Jolanta; Brüning, Thomas; Eiriz Delgado, Iván; Santha, Petra; Biverstål, Henrik; Jansone, Baiba; Haugen, Håvard Jostein; Krohn, Markus & Pahnke, Jens (2017). Improved method for cannula fixation for long-term intracerebral brain infusion. Journal of Neuroscience Methods.  ISSN 0165-0270.  290, s 145- 150 . doi: 10.1016/j.jneumeth.2017.07.026
• Steffen, Johannes; Krohn, Markus; Schwitlick, christina; Brüning, Thomas; Paarmann, Kristin; Pietrzik, Claus U; Biverstål, Henrik; Jansone, Baiba; Langer, Oliver & Pahnke, Jens (2017). Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.. Acta neuropathologica communications.  ISSN 2051-5960.  5(1) . doi: 10.1186/s40478-017-0448-2 Fulltekst i vitenarkiv.
• Bernstein, Hans-Gert; Hildebrandt, Jens; Dobrowolny, Henrik; Steiner, J.; Bogerts, Bernhard & Pahnke, Jens (2016). Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula. Schizophrenia Research.  ISSN 0920-9964.  177(1-3), s 52- 58 . doi: 10.1016/j.schres.2016.02.036
• Hofrichter, Jacqueline; Krohn, Markus; Schumacher, Toni; Lange, Cathleen; Feistel, Björn; Walbroel, Bernd & Pahnke, Jens (2016). Sideritis spp. extracts enhance memory and learning in Alzheimer's β-amyloidosis mouse models and aged C57Bl/6 mice. Journal of Alzheimer's Disease.  ISSN 1387-2877.  53(3), s 967- 980 . doi: 10.3233/JAD-160301
• Marques, Fernanda; Sousa, Joao Carlos; Brito, Maria Alexandra; Pahnke, Jens; Santos, Cecilia; Correia-Neves, Margarida & Palha, Joana Almeida (2016). The choroid plexus in health and in disease: dialogues into and out of the brain. Neurobiology of Disease.  ISSN 0969-9961.  (107), s 32- 40 . doi: 10.1016/j.nbd.2016.08.011
• Möhle, Luisa; Israel, Nicole; Paarmann, Kristin; Krohn, Markus; Pietkiewicz, Sabine; Müller, Andreas; Lavrik, Inna N; Buguliskis, Jeffrey S; Schott, Björn H; Schlüter, Dirk; Gundelfinger, Eckart D; Montag, Dirk; Seifert, Ulrike; Pahnke, Jens & Dunay, Ildiko Rita (2016). Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta neuropathologica communications.  ISSN 2051-5960.  4 . doi: 10.1186/s40478-016-0293-8
• Steffen, Johannes; Krohn, Markus; Paarmann, Kristin; Schwitlick, christina; Brüning, Thomas; Marreiros, Rita; Müller-Schiffmann, Andreas; Korth, Carsten; Braun, Katharina & Pahnke, Jens (2016). Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta neuropathologica communications.  ISSN 2051-5960.  5(49) . doi: 10.1186/s40478-016-0363-y
• Apostolova, Ivayla; Niedzielska, Dagmara; Derlin, Thorsten; Koziolek, Eva J.; Amthauer, Holger; Salmen, Benedikt; Pahnke, Jens; Brenner, Winfried; Mautner, Victor F. & Buchert, Ralph (2015). Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: Towards a biomarker of neurologic deficits. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  35(8), s 1304- 1312 . doi: 10.1038/jcbfm.2015.43
• Budworth, Helen; Harris, Faye R.; Williams, Paul; Lee, Do Yup; Holt, Amy; Pahnke, Jens; Szczesny, Bartosz; McMurray, Cynthia T.; Acevedo-Torres, Karina & Ayala-Peña, Sylvette (2015). Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s disease. PLoS Genetics.  ISSN 1553-7390.  11:e1005267(8) . doi: 10.1371/journal.pgen.1005267
• Fröhlich, Christina; Zschiebsch, Katja; Gröger, Victoria; Paarmann, Kristin; Steffen, Johannes; Thurm, Christoph; Schropp, Eva-Maria; Brüning, Thomas; Gellerich, Frank; Radloff, Martin; Schwabe, Rainer; Lachmann, Ingolf; Krohn, Markus; Ibrahim, Saleh & Pahnke, Jens (2015). Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies. Molecular Neurobiology.  ISSN 0893-7648.  Published ahead of print . doi: 10.1007/s12035-015-9399-4 Vis sammendrag

  Parkinson ’ s disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most com- mon neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to en- hance clearance of amyloid- β from the brain of APP- transgenic mice leading to beneficial clinical outcome. It has been discussed whether sp ecific mitochondrial alter- ations contribute to disease p rogression or even prevent toxic peptide deposition, as seen in many neurodegener- ative diseases. Here, we investigated α -synuclein- transgenic C57BL/6J mice with the A30P mutation, and a novel A30P C57BL/6J mouse model with three mitochondrial DNA polymorphisms in the ND3, COX3 and mtRNA Arg genes, as found in the inbred NOD/LtJ mouse strain. We were able to detect that the new mod- el has increased mitochondrial complex II-respiration which occurs in parallel to neuronal loss and improved motor performance, although it exhibits higher amounts of high molecular weight species of α -synuclein. High molecular weight aggregates of different peptides are controversially discussed in the light of neurodegenera- tion. A favourable hypothesis states that high molecular weight species are protective and of minor importance for the pathogenesis of neurodegenerative disorders as compared to the extreme neurotoxic monomers and olig- omers. Summarising, our results point to a potentially protective and beneficial effect of specific mitochondrial polymorphisms which cause improved mitochondrial complex II-respiration in α -synucleinopathies, an effect that could be exploited further for pharmaceutical interventions.

• Krohn, Markus; Bracke, Alexander; Avchalumov, Yosef; Schumacher, Toni; Hofrichter, Jacqueline; Paarmann, Kristin; Fröhlich, Christina; Lange, Cathleen; Brüning, Thomas; Von Bohlen und Halbach, Oliver & Pahnke, Jens (2015). Accumulation of murine amyloid-β mimics early Alzheimer's disease. Brain.  ISSN 0006-8950.  138(8), s 2370- 2382 . doi: 10.1093/brain/awv137
• Lill, Christina M.; Rengmark, Aina Sylvia Haugen; Pihlstrøm, Lasse; Fogh, Isabella; Shatunov, Aleksey; Sleiman, Patrick M.; Wang, Li-San; Liu, Tian; Lassen, Christina F.; Meissner, Esther; Alexopoulos, Panos; Calvo, Andrea; Chio, Adriano; Dizdar, Nil; Faltraco, Frank; Forsgren, Lars; Kirchheiner, Julia; Kurz, Alexander; Larsen, Jan Petter; Liebsch, Maria; Linder, Jan; Morrison, Karen E; Nissbrandt, Hans; Otto, Markus; Pahnke, Jens; Partch, Amanda; Restagno, Gabriella; Rujescu, Dan; Schnack, Cathrin; Shaw, Christopher E.; Shaw, Pamela J.; Tumani, Hayrettin; Tysnes, Ole-Bjørn; Valladares, Otto; Silani, Vincenzo; van den Berg, Leonard H.; Van Rheenen, Wouter; Veldink, Jan H.; Lindenberger, Ulman; Steinhagen-Thiessen, Elisabeth; Teipel, Stefan; Perneczky, Robert; Hakonarson, Hakon; Hampel, Harald; Von Arnim, Christine A.F.; Olsen, Jørgen H.; Van Deerlin, Vivianna M.; Al-Chalabi, Ammar; Toft, Mathias; Ritz, Beate & Bertram, Lars (2015). The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease. Alzheimer's & Dementia.  ISSN 1552-5260.  11(12), s 1407- 1416 . doi: 10.1016/j.jalz.2014.12.009
• Wanek, Thomas; Römermann, Kerstin; Mairinger, Severin; Stanek, Johann; Sauberer, Michael; Filip, Thomas; Traxl, Alexander; Kuntner, Claudia; Pahnke, Jens; Bauer, Florian; Erker, Thomas; Löscher, Wolfgang; Müller, Markus & Langer, Oliver (2015). Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with positron emission tomography. Molecular Pharmaceutics.  ISSN 1543-8384.  12(9), s 3214- 3225 . doi: 10.1021/acs.molpharmaceut.5b00168
• Bernstein, Hans-Gert; Hölzl, Gloria; Dobrowolny, Henrik; Hildebrandt, Jens; Trubner, Kurt; Krohn, Markus; Bogerts, Bernhard & Pahnke, Jens (2014). Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. Mechanisms of Ageing and Development.  ISSN 0047-6374.  141, s 12- 21 . doi: 10.1016/j.mad.2014.08.003
• Pahnke, Jens; Fröhlich, Christina; Paarmann, Kristin; Krohn, Markus; Bogdanovic, Nenad; Aarsland, Dag & Winblad, Bengt (2014). Cerebral ABC Transporter-common Mechanisms May Modulate Neurodegenerative Diseases and Depression in Elderly Subjects. Archives of Medical Research.  ISSN 0188-4409.  45(8), s 738- 743 . doi: 10.1016/j.arcmed.2014.10.010

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• Moussavi, Nastaran; Azizullah, Hasina; Pahnke, Jens; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2019). Greek mountain tea, a medicinal plant from Mediterranean countries and Balkan.
• Moussavi, Nastaran; Azizullah, Hasina; Pahnke, Jens; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2019). Greek mountain tea, a medicinal plant from the Mediterranean countries and Balkan..
• Azizullah, Hasina; Pahnke, Jens; Moussavi, Nastaran; Malterud, Karl Egil & Wangensteen, Helle (2018). Gresk fjellte, en medisinplante fra middelhavslandene og Balkan.
• Bernstein, Hans-Gert; Hildebrandt, J.; Dobrowolny, Henrik; Steiner, J.; Bogerts, Bernhard & Pahnke, Jens (2018). Corrigendum to 'Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula' [Schizophr. Res. 2016 Nov;177(1?3):52?58] (S0920996416300901) (10.1016/j.schres.2016.02.036)). Schizophrenia Research.  ISSN 0920-9964.  197, s 622- 623 . doi: 10.1016/j.schres.2018.03.036
• Jansone, Baiba; Pahnke, Jens & Biverstål, Henrik (2017). Alcheimera slimības izpētes aktualitātes. Latvijas ārsts.  ISSN 1019-5068.  s 48- 53
• Mairinger, Severin; Wanek, Thomas; Traxl, Alexander; Krohn, Markus; Stanek, Johann; Filip, Thomas; Sauberer, Michael; Kuntner, Claudia; Pahnke, Jens & Langer, Oliver (2016). 7-[11C]methyl-6-bromopurine, a PET tracer to measure brain Mrp1 function: radiosynthesis and first PET evaluation in mice. 32nd International Austrian Winter Symposium, Zell am See, the Netherlands. 20-23 January 2016. EJNMMI Research.  ISSN 2191-219X.  6(32) . doi: 10.1186/s13550-016-0168-9

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