Oleksandr Frei

Researcher - NORMENT part UiO
Image of Oleksandr Frei
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Visiting address Oslo Universitetssykehus HF - Ullevål Avdeling for psykoseforskning Bygg 49 0424 OSLO
Postal address OUS, Postboks 4956 Nydalen 0424 OSLO

I work at NORMENT (Norwegian Centre for Mental Disorders Research) at UiO Faculty of Medicine. We study Genetics of Psychiatric Disorders, identifying rare genetic variants or variation in gene expression in order to uncover hidden heritability of Schizophrenia and other mental disorders.

I have background in mathematics and machine learning. My PhD thesis is "Symmetry and randomizations in combinatorial theory of generalization ability" (Moscow Institute of Physics and Technology, 2013). I also have few years of experience in building industrial software. I worked on Search Engine for Sharepoint (Microsoft, 2010-2013), and on Petrel E&P Software Platform for seismic to simulation reservoir engineering (Schlumberger, 2014-2016).

My hobbies are cycling, skiing, hiking, and more cycling.

Publications

  • Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience.  ISSN 1662-4548.  13 . doi: 10.3389/fnins.2019.00220 Full text in Research Archive.
  • Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders M & Andreassen, Ole Andreas (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience.  ISSN 1662-4548. . doi: 10.3389/fnins.2019.00220 Full text in Research Archive.
  • Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Maeland, Steffen; O'Connell, Kevin S.; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-10310-0
  • Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, S.; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Karolinska Schizophrenia Pro, KaSP; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience.  ISSN 1097-6256.  22, s 1617- 1623 . doi: 10.1038/s41593-019-0471-7
  • Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2019). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 10 . doi: 10.1038/s41380-018-0332-x Full text in Research Archive.
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders & Andreassen, Ole Andreas (2019). The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges. Psychiatric Genetics.  ISSN 0955-8829. . doi: 10.1097/YPG.0000000000000234 Show summary
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders & Andreassen, Ole Andreas (2019). Discovery of shared genomic loci using the conditional false discovery rate approach. Human Genetics.  ISSN 0340-6717.  s 1- 10 . doi: 10.1007/s00439-019-02060-2 Full text in Research Archive.
  • Fan, Chun Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Chen, Chi-Hua; Holland, Dominic; Lo, Min-Tzu; Sundar, Vijay S.; Frei, Oleksandr; Jernigan, Terry L.; Andreassen, Ole Andreas & Dale, Anders (2018). Beyond heritability: Improving discoverability in imaging genetics. Human Molecular Genetics.  ISSN 0964-6906.  27(1), s R22- R28 . doi: 10.1093/hmg/ddy082
  • Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2018). Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports.  ISSN 2045-2322.  8:12585, s 1- 9 . doi: 10.1038/s41598-018-30387-9 Full text in Research Archive.
  • van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 13 . doi: 10.1038/s41380-018-0262-7 Full text in Research Archive.
  • Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bézieau, Stéphane; Dale, Anders; Mills, Ian Geoffrey & Andreassen, Ole Andreas (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports.  ISSN 2045-2322.  674(8), s 1- 8 . doi: 10.1038/s41598-017-16481-4 Full text in Research Archive.
  • Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr; Bettella, Francesco; Witoelar, Aree; Li, Wen; Eriksen, Jon Alm; Krull, Florian; Djurovic, Srdjan; Faraone, Stephen V.; Reichborn-Kjennerud, Ted; Thompson, Wesley K; Johansson, Stefan; Haavik, Jan; Dale, Anders; Wang, Yunpeng & Andreassen, Ole Andreas (2017). Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment. Journal of the American Academy of Child and Adolescent Psychiatry.  ISSN 0890-8567.  57(2), s 86- 95 . doi: 10.1016/j.jaac.2017.11.013 Full text in Research Archive.
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Kauppi, Karolina; Hill, W. David; Li, Wen; Wang, Yunpeng; Krull, Florian; Bettella, Francesco; Eriksen, Jon Alm; Witoelar, Aree; Davies, Gail; Fan, Chun Chieh; Thompson, Wesley Kurt; Lam, Max; Lencz, Todd; Chen, Chi-Hua; Ueland, Torill; Jönsson, Erik Gunnar; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2017). Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA psychiatry.  ISSN 2168-6238.  74(10), s 1065- 1075 . doi: 10.1001/jamapsychiatry.2017.1986 Full text in Research Archive.
  • Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek P; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophrenia Bulletin.  ISSN 0586-7614.  44(4), s 854- 864 . doi: 10.1093/schbul/sbx148
  • Smeland, Olav Bjerkehagen; Wang, Yunpeng; Lo, Min-Tzu; Li, Wen; Frei, Oleksandr; Witoelar, Aree; Tesli, Martin Steen; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders & Andreassen, Ole Andreas (2017). Identification of genetic loci shared between schizophrenia and the Big Five personality traits. Scientific Reports.  ISSN 2045-2322.  7:2222(1), s 1- 9 . doi: 10.1038/s41598-017-02346-3 Full text in Research Archive.
  • Winsvold, Bendik K S; Bettella, Francesco; Witoelar, Aree; Anttila, Verneri; Gormley, Padhraig; Kurth, Tobias; Terwindt, Gisela M; Freilinger, Tobias; Frei, Oleksandr; Shadrin, Alexey A.; Wang, Yunpeng; Dale, Anders; Van Den Maagdenberg, Arn M.J.M.; Chasman, Daniel I; Nyholt, Dale R; Palotie, Aarno; Andreassen, Ole Andreas & Zwart, John-Anker (2017). Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLOS ONE.  ISSN 1932-6203.  s 1- 15 . doi: 10.1371/journal.pone.0185663 Full text in Research Archive.

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  • Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2018). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and intelligence.
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Dale, Anders & Andreassen, Ole Andreas (2017). Combined Analysis of Large Genetic Samples. New Statistical Approaches Improve Gene Discovery.
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Alexey, Shadrin; Li, Wen; Florian, Krull; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). Increased discovery of risk loci for bipolar disorder by leveraging prior probabilities of true associations using the covariate modulated mixture model (CM3).
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Shadrin, Alexey A.; Li, Wen; Krull, Florian; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). C-Reactive Protein Levels and Schizophrenia Share Genetic Influences.
  • Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Conditional false discovery rate analysis of genome-wide association studies uncovers genetic loci shared between schizophrenia and volumes of hippocampus, putamen and intracranial volume.
  • Smeland, Olav Bjerkehagen; Kauppi, Karolina; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hill, David W; Davies, Gail; Eriksen, Jon Alm; Witoelar, Aree; Bettella, Francesco; Fan, Chun Chieh; Thompson, Wesley Kurt; Chen, Chi-Hua; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2016). Schizophrenia and general cognitive function share genetic influences.

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Published June 7, 2016 8:55 AM - Last modified Apr. 5, 2018 5:19 PM

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