Oleksandr Frei

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Visiting address Oslo Universitetssykehus HF - Ullevål Avdeling for psykoseforskning Bygg 49 0424 Oslo
Postal address OUS, Postboks 4956 Nydalen 0424 Oslo
Other affiliations Centre for Precision Psychiatry

I work at NORMENT (Norwegian Centre for Mental Disorders Research) at UiO Faculty of Medicine. We study Genetics of Psychiatric Disorders, identifying rare genetic variants or variation in gene expression in order to uncover hidden heritability of Schizophrenia and other mental disorders.

I have background in mathematics and machine learning. My PhD thesis is "Symmetry and randomizations in combinatorial theory of generalization ability" (Moscow Institute of Physics and Technology, 2013). I also have few years of experience in building industrial software. I worked on Search Engine for Sharepoint (Microsoft, 2010-2013), and on Petrel E&P Software Platform for seismic to simulation reservoir engineering (Schlumberger, 2014-2016).

My hobbies are cycling, skiing, hiking, and more cycling.

Publications

  • Parekh, Pravesh; Fan, Chun Chieh; Frei, Oleksandr; Palmer, Clare E.; Smith, Diana M. & Makowski, Carolina [Show all 17 contributors for this article] (2024). FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data. Human Brain Mapping. ISSN 1065-9471. 45(2). doi: 10.1002/hbm.26579.
  • Holen, Børge; Kutrolli, Gleda; Shadrin, Alexey; Icick, Romain; Hindley, Guy & Rødevand, Linn [Show all 16 contributors for this article] (2023). Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability. Drug and Alcohol Dependence. ISSN 0376-8716. 256. doi: 10.1016/j.drugalcdep.2023.111058. Full text in Research Archive
  • Nordengen, Kaja; Cappelletti, Chiara; Bahrami, Shahram; Frei, Oleksandr; Pihlstrøm, Lasse & Henriksen, Sandra Pilar [Show all 11 contributors for this article] (2023). Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease. Brain. ISSN 0006-8950. p. 1–13. doi: 10.1093/brain/awad297. Full text in Research Archive
  • Bøen, Rune; Kaufmann, Tobias Herbert; van der Meer, Dennis; Frei, Oleksandr; Agartz, Ingrid & Ames, David [Show all 53 contributors for this article] (2023). Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers. Biological Psychiatry. ISSN 0006-3223. 95(2), p. 147–160. doi: 10.1016/j.biopsych.2023.08.018. Full text in Research Archive
  • Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos ; Bahrami, Shahram & Nerhus, Mari [Show all 19 contributors for this article] (2023). Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci. Schizophrenia Bulletin. ISSN 0586-7614. 49(6), p. 1654–1664. doi: 10.1093/schbul/sbad063. Full text in Research Archive
  • Rødevand, Linn Nilsen; Rahman, Zillur; Hindley, Guy Frederick Lanyon; Smeland, Olav Bjerkehagen; Frei, Oleksandr & Filiz, Tahir Tekin [Show all 15 contributors for this article] (2023). Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors. American Journal of Psychiatry. ISSN 0002-953X. 180(11), p. 815–826. doi: 10.1176/APPI.AJP.20220660.
  • Steen, Nils Eiel; Rahman, Zillur; Szabo, Attila; Hindley, Guy; Parker, Nadine & Cheng, Weiqiu [Show all 20 contributors for this article] (2023). Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities. Schizophrenia Bulletin. ISSN 0586-7614. 49(5), p. 1345–1354. doi: 10.1093/schbul/sbad082. Full text in Research Archive
  • Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; Parekh, Pravesh; Shadrin, Alexey & Maximov, Ivan [Show all 12 contributors for this article] (2023). Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-023-02264-z.
  • Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey & Parker, Nadine [Show all 20 contributors for this article] (2023). Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders. Psychoneuroendocrinology. ISSN 0306-4530. 157. doi: 10.1016/j.psyneuen.2023.106368. Full text in Research Archive
  • Akdeniz, Bayram Cevdet ; Mattingsdal, Morten; Dominguez-Valentin, Mev; Frei, Oleksandr; Shadrin, Alexey & Puustusmaa, Mikk [Show all 12 contributors for this article] (2023). A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population. Cancers. ISSN 2072-6694. 15(16). doi: 10.3390/cancers15164124. Full text in Research Archive
  • Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Rahman, Zillur & Bahrami, Shahram [Show all 17 contributors for this article] (2023). Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis. Genome Medicine. ISSN 1756-994X. 15(1). doi: 10.1186/s13073-023-01212-4. Full text in Research Archive
  • Hope, Sigrun; Shadrin, Alexey; Lin, Aihua; Bahrami, Shahram; Rødevand, Linn & Frei, Oleksandr [Show all 17 contributors for this article] (2023). Bidirectional genetic overlap between autism spectrum disorder and cognitive traits. Translational Psychiatry. ISSN 2158-3188. 13(1), p. 1–9. doi: 10.1038/s41398-023-02563-7. Full text in Research Archive
  • Bang, Lasse; Bahrami, Shahram; Hindley, Guy; Smeland, Olav Bjerkehagen; Rødevand, Linn & Jaholkowski, Piotr Pawel [Show all 18 contributors for this article] (2023). Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa. Translational Psychiatry. ISSN 2158-3188. 13. doi: 10.1038/s41398-023-02585-1. Full text in Research Archive
  • Campbell, Megan L.; Dalvie, Shareefa; Shadrin, Alexey; van der Meer, Dennis; O'Connell, Kevin Sean & Frei, Oleksandr [Show all 9 contributors for this article] (2023). Distributed Genetic Effects of the Corpus Callosum Subregions Suggest Links to Neuropsychiatric Disorders and Related Traits. Acta Neuropsychiatrica. ISSN 0924-2708. doi: 10.1017/neu.2023.32. Full text in Research Archive
  • Karadag, Naz; Shadrin, Alexey; O'Connell, Kevin Sean; Hindley, Guy Frederick Lanyon; Rahman, Zillur & Parker, Nadine [Show all 18 contributors for this article] (2023). Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders. Brain. ISSN 0006-8950. 146(8), p. 3392–3403. doi: 10.1093/brain/awad038. Full text in Research Archive
  • Mufford, Mary S.; van der Meer, Dennis; Kaufmann, Tobias Herbert; Frei, Oleksandr; Ramesar, Raj & Thompson, Paul M. [Show all 11 contributors for this article] (2023). The Genetic Architecture of Amygdala Nuclei. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2023.06.022. Full text in Research Archive
  • Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; O'Connell, Kevin Sean; Karthikeyan, Sandeep & Holen, Børge [Show all 19 contributors for this article] (2023). Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2023.06.008. Full text in Research Archive
  • Roelfs, Daniel; Frei, Oleksandr; van der Meer, Dennis; Tissink, Elleke; Shadrin, Alexey & Alnæs, Dag [Show all 9 contributors for this article] (2023). Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank. BMC Psychiatry. ISSN 1471-244X. 23(1). doi: 10.1186/s12888-023-04905-7. Full text in Research Archive
  • Hindley, Guy Frederick Lanyon; Shadrin, Alexey; van der Meer, Dennis; Parker, Nadine; Cheng, Weiqiu & O'Connell, Kevin Sean [Show all 23 contributors for this article] (2023). Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy. Nature Human Behaviour. ISSN 2397-3374. 7, p. 1584–1600. doi: 10.1038/s41562-023-01630-9.
  • Askeland, Ragna Bugge; Hannigan, Laurie John; O'Connell, Kevin Sean; Corfield, Elizabeth Claire; Frei, Oleksandr & Thapar, Anita [Show all 11 contributors for this article] (2023). Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood. Translational Psychiatry. ISSN 2158-3188. 13. doi: 10.1038/s41398-023-02522-2. Full text in Research Archive
  • Makowski, Carolina; Wang, Hao; Srinivasan, Anjali; Qi, Anna; Qiu, Yuqi & van der Meer, Dennis [Show all 11 contributors for this article] (2023). Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 120(11). doi: 10.1073/pnas.2214834120. Full text in Research Archive
  • Leonardsen, Esten Høyland; Vidal-Piñeiro, Didac; Roe, James Michael; Frei, Oleksandr; Shadrin, Alexey & Iakunchykova, Olena [Show all 14 contributors for this article] (2023). Genetic architecture of brain age and its casual relations with brain and mental disorders. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-023-02087-y. Full text in Research Archive
  • Reas, Emilie T.; Shadrin, Alexey; Frei, Oleksandr; Motazedi, Ehsan; McEvoy, Linda & Bahrami, Shahram [Show all 22 contributors for this article] (2023). Improved multimodal prediction of progression from MCI to Alzheimer's disease combining genetics with quantitative brain MRI and cognitive measures. Alzheimer's & Dementia. ISSN 1552-5260. 19(11), p. 5151–5158. doi: 10.1002/alz.13112. Full text in Research Archive
  • O'Connell, Kevin Sean; Koch, Elise; Lenk, Hasan Cagin; Akkouh, Ibrahim Ahmed; Hindley, Guy Frederick Lanyon & Jaholkowski, Piotr Pawel [Show all 16 contributors for this article] (2023). Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia. Psychiatry Research. ISSN 0165-1781. 325. doi: 10.1016/j.psychres.2023.115217. Full text in Research Archive
  • Holen, Børge; Shadrin, Alexey; Icick, Romain; Filiz, Tahir Tekin; Hindley, Guy Frederick Lanyon & Rødevand, Linn [Show all 19 contributors for this article] (2023). Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression. Addiction Biology. ISSN 1355-6215. 28(6). doi: 10.1111/adb.13282. Full text in Research Archive
  • Oddsson, Asmundur; Sulem, Patrick; Sveinbjornsson, Gardar; Arnadottir, Gudny A.; Steinthorsdottir, Valgerdur & Halldorsson, Gisli H. [Show all 54 contributors for this article] (2023). Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality. Nature Communications. ISSN 2041-1723. 14. doi: 10.1038/s41467-023-38951-2. Full text in Research Archive
  • Fominykh, Vera; Shadrin, Alexey; Jaholkowski, Piotr Pawel; Bahrami, Shahram; Athanasiu, Lavinia & Wightman, Douglas P. [Show all 13 contributors for this article] (2023). Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system. Neurobiology of Disease. ISSN 0969-9961. 183. doi: 10.1016/j.nbd.2023.106174. Full text in Research Archive
  • Cheng, Weiqiu; Parker, Nadine; Karadag, Naz; Koch, Elise; Hindley, Guy Frederick Lanyon & Icick, Romain [Show all 22 contributors for this article] (2023). The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study. The Lancet Psychiatry. ISSN 2215-0374. 10(6), p. 441–451. doi: 10.1016/S2215-0366(23)00143-8. Full text in Research Archive
  • Smith, Diana M.; Loughnan, Robert; Friedman, Naomi P.; Parekh, Pravesh; Frei, Oleksandr & Thompson, Wesley K. [Show all 10 contributors for this article] (2023). Heritability Estimation of Cognitive Phenotypes in the ABCD Study<sup>®</sup> Using Mixed Models. Behavior Genetics. ISSN 0001-8244. 53(3), p. 169–188. doi: 10.1007/s10519-023-10141-2. Full text in Research Archive
  • Jaholkowski, Piotr; Shadrin, Alexey A.; Jangmo, Andreas; Frei, Evgeniia; Woldeyohannes, Markos Tesfaye & Hindley, Guy F. L. [Show all 23 contributors for this article] (2023). Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders. JAMA psychiatry. ISSN 2168-6238. 80(7), p. 738–742. doi: 10.1001/jamapsychiatry.2023.1137.
  • Bøen, Rune; Kaufmann, Tobias; Frei, Oleksandr; van der Meer, Dennis; Djurovic, Srdjan & Andreassen, Ole [Show all 9 contributors for this article] (2023). No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank. Translational Psychiatry. ISSN 2158-3188. 13:61, p. 1–6. doi: 10.1038/s41398-023-02358-w. Full text in Research Archive
  • Andreassen, Ole; Hindley, Guy Frederick Lanyon; Frei, Oleksandr & Smeland, Olav Bjerkehagen (2023). New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications. World Psychiatry. ISSN 1723-8617. 22(1), p. 4–24. doi: 10.1002/wps.21034.
  • Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik Slagvold; O`Connell, Kevin S.; Frei, Oleksandr & Shadrin, Alexey [Show all 16 contributors for this article] (2022). Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. Brain. ISSN 0006-8950. doi: 10.1093/brain/awab267.
  • Akdeniz, Bayram Cevdet ; Frei, Oleksandr; Shadrin, Alexey; Vetrov, Dmitry; Kropotov, Dmitry & Dale, Anders [Show all 8 contributors for this article] (2022). Finemap-MiXeR: A variational Bayesian approach for genetic finemapping. bioRxiv. ISSN 2692-8205.
  • Akdeniz, Bayram Cevdet ; Frei, Oleksandr; Hagen, Espen; Filiz, Tahir Tekin; Karthikeyan, Sandeep & Pasman, Joëlle [Show all 18 contributors for this article] (2022). COGEDAP: A COmprehensive GEnomic Data Analysis Platform. arXiv.org. ISSN 2331-8422.
  • van der Meer, Dennis; Gurholt, Tiril Pedersen; Sønderby, Ida Elken; Shadrin, Alexey; Hindley, Guy Frederick Lanyon & Rahman, Zillur [Show all 18 contributors for this article] (2022). The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition. Communications Biology. ISSN 2399-3642. 5(1). doi: 10.1038/s42003-022-04237-4. Full text in Research Archive
  • Loughnan, Robert J.; Shadrin, Alexey; Frei, Oleksandr; van der Meer, Dennis; Zhao, Weiqi & Palmer, Clare E. [Show all 12 contributors for this article] (2022). Generalization of cortical MOSTest genome-wide associations within and across samples. NeuroImage. ISSN 1053-8119. 263. doi: 10.1016/j.neuroimage.2022.119632. Full text in Research Archive
  • Fan, Chun Chieh; Loughnan, Robert; Makowski, Carolina; Pecheva, Diliana; Chen, Chi-Hua & Hagler, Donald J. [Show all 12 contributors for this article] (2022). Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain. Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-30110-3. Full text in Research Archive
  • Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Rahman, Zillur; Frei, Oleksandr; Bahrami, Shahram & Shadrin, Alexey [Show all 17 contributors for this article] (2022). The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 189(6), p. 207–218. doi: 10.1002/ajmg.b.32907. Full text in Research Archive
  • Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean & Wang, Yunpeng [Show all 20 contributors for this article] (2022). Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-022-01751-z. Full text in Research Archive
  • Bahrami, Shahram; Nordengen, Kaja; Shadrin, Alexey; Frei, Oleksandr; van der Meer, Dennis & Dale, Anders [Show all 9 contributors for this article] (2022). Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders. Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-31086-w. Full text in Research Archive
  • Torgersen, Kristin Stensland; Rahman, Zillur; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Parker, Nadine & Frei, Oleksandr [Show all 14 contributors for this article] (2022). Shared genetic loci between depression and cardiometabolic traits. PLoS Genetics. ISSN 1553-7390. 18(5). doi: 10.1371/journal.pgen.1010161. Full text in Research Archive
  • Hindley, Guy; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; O'Connell, Kevin Sean & Icick, Romain [Show all 17 contributors for this article] (2022). Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation. American Journal of Psychiatry. ISSN 0002-953X. 179(11), p. 833–843. doi: 10.1176/appi.ajp.21101051.
  • Icick, Romain; Shadrin, Alexey; Holen, Børge; Karadag, Naz; Lin, Aihua & Hindley, Guy [Show all 17 contributors for this article] (2022). Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings. Neuropsychopharmacology. ISSN 0893-133X. 47, p. 1883–1891. doi: 10.1038/s41386-022-01401-6.
  • Saevarsdottir, Saedis; Stefansdottir, Lilja; Sulem, Patrick; Thorleifsson, Gudmar; Ferkingstad, Egil & Rutsdottir, Gudrun [Show all 78 contributors for this article] (2022). Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset. Annals of the Rheumatic Diseases. ISSN 0003-4967. 81(8), p. 1085–1095. doi: 10.1136/annrheumdis-2021-221754. Full text in Research Archive
  • Motazedi, Ehsan; Cheng, Weiqiu; Thomassen, Jesper Qvist; Frei, Oleksandr; Rongve, Arvid & Athanasiu, Lavinia [Show all 30 contributors for this article] (2022). Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations. Journal of Alzheimer's Disease. ISSN 1387-2877. 88(4), p. 1533–1544. doi: 10.3233/JAD-220174.
  • van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan & Wolfers, Thomas [Show all 17 contributors for this article] (2022). Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology. Biological Psychiatry. ISSN 0006-3223. 92(4), p. 291–298. doi: 10.1016/j.biopsych.2021.12.007. Full text in Research Archive
  • Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin Sean; Frei, Oleksandr & Shadrin, Alexey [Show all 39 contributors for this article] (2022). Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. Brain. ISSN 0006-8950. 145(1), p. 142–153. doi: 10.1093/brain/awab267. Full text in Research Archive
  • Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O’Connell, Kevin S.; Frei, Oleksandr & Shadrin, Alexey [Show all 13 contributors for this article] (2021). Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01576-4.
  • Mullins, Niamh; Forstner, Andreas J.; O'Connell, Kevin Sean; Coombes, Brandon; Coleman, Jonathan R. I. & Qiao, Zhen [Show all 59 contributors for this article] (2021). Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics. ISSN 1061-4036. 53, p. 817–829. doi: 10.1038/s41588-021-00857-4.
  • van der Meer, Dennis; Kaufmann, Tobias; Shadrin, Alexey; Makowski, Carolina; Frei, Oleksandr & Roelfs, Daniel [Show all 17 contributors for this article] (2021). The genetic architecture of human cortical folding. Science Advances. ISSN 2375-2548. 7(51), p. 1–9. doi: 10.1126/sciadv.abj9446. Full text in Research Archive
  • Shadrin, Alexey A.; Kaufmann, Tobias; van der Meer, Dennis; Palmer, Clare E.; Makowski, Carolina & Loughnan, Robert [Show all 22 contributors for this article] (2021). Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology. NeuroImage. ISSN 1053-8119. 244, p. 1–8. doi: 10.1016/j.neuroimage.2021.118603. Full text in Research Archive
  • Pihlstrøm, Lasse; Fan, Chun Chieh; Frei, Oleksandr; Tan, Manuela; Karunamuni, Roshan A. & Blauwendraat, Cornelis [Show all 12 contributors for this article] (2021). Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score. Movement Disorders. ISSN 0885-3185. doi: 10.1002/mds.28808. Full text in Research Archive
  • Wiström, Erik David; O'Connell, Kevin Sean; Karadag, Naz; Bahrami, Shahram; Hindley, Guy Frederick Lanyon & Lin, Aihua [Show all 14 contributors for this article] (2021). Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci. Addiction. ISSN 0965-2140. doi: 10.1111/add.15680. Full text in Research Archive
  • Monereo-Sánchez, Jennifer; Schram, Miranda T.; Frei, Oleksandr; O'Connell, Kevin Sean; Shadrin, Alexey & Smeland, Olav Bjerkehagen [Show all 11 contributors for this article] (2021). Genetic Overlap Between Alzheimer’s Disease and Depression Mapped Onto the Brain. Frontiers in Neuroscience. ISSN 1662-4548. 15, p. 1–9. doi: 10.3389/fnins.2021.653130. Full text in Research Archive
  • O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Cheng, Weiqiu [Show all 16 contributors for this article] (2021). Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes. Biological Psychiatry. ISSN 0006-3223. p. 1–11. doi: 10.1016/j.biopsych.2021.07.007. Full text in Research Archive
  • Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr & Shadrin, Alexey [Show all 13 contributors for this article] (2021). Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking. Translational Psychiatry. ISSN 2158-3188. 11:466, p. 1–10. doi: 10.1038/s41398-021-01576-4. Full text in Research Archive
  • Elvsåshagen, Torbjørn; Shadrin, Alexey; Frei, Oleksandr; van der Meer, Dennis; Bahrami, Shahram & Kumar, Vinod J. [Show all 10 contributors for this article] (2021). The genetic architecture of the human thalamus and its overlap with ten common brain disorders. Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-23175-z. Full text in Research Archive
  • Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun Chieh; Shadrin, Alexey & Smeland, Olav Bjerkehagen [Show all 8 contributors for this article] (2021). The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity. Genetics. ISSN 0016-6731. 217(3), p. 1–21. doi: 10.1093/genetics/iyaa046.
  • Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean & Smeland, Olav Bjerkehagen [Show all 10 contributors for this article] (2021). Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors. Translational Psychiatry. ISSN 2158-3188. 11(1), p. 1–13. doi: 10.1038/s41398-021-01466-9. Full text in Research Archive
  • Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi & Ellegaard, Maria [Show all 76 contributors for this article] (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01213-0. Full text in Research Archive
  • O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia & Smeland, Olav Bjerkehagen [Show all 13 contributors for this article] (2021). Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank. Psychological Medicine. ISSN 0033-2917. p. 1–11. doi: 10.1017/S0033291721000179. Full text in Research Archive
  • Rødevand, Linn ; Bahrami, Shahram; Frei, Oleksandr; Chu, Yunhan; Shadrin, Alexey A. & O'Connell, Kevin Sean [Show all 14 contributors for this article] (2021). Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01527-z. Full text in Research Archive
  • Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Show all 20 contributors for this article] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), p. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Full text in Research Archive
  • Gurholt, Tiril Pedersen; Kaufmann, Tobias; Frei, Oleksandr; Alnæs, Dag; Haukvik, Unn Kristin H. & van der Meer, Dennis [Show all 17 contributors for this article] (2021). Population-based body–brain mapping links brain morphology with anthropometrics and body composition. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01414-7. Full text in Research Archive
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  • Bahrami, Shahram; Shadrin, Alexey A.; Frei, Oleksandr; O`Connell, Kevin; Bettella, Francesco & Krull, Florian [Show all 15 contributors for this article] (2021). Genetic loci shared between major depression and intelligence with mixed directions of effect. Nature Human Behaviour. ISSN 2397-3374. p. 1–9. doi: 10.1038/s41562-020-01031-2.
  • Roelfs, Daniel; Alnæs, Dag; Frei, Oleksandr; van der Meer, Dennis; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-021-01313-x. Full text in Research Archive
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  • Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun-Chieh; Shadrin, Alexey A. & Smeland, Olav Bjerkehagen [Show all 10 contributors for this article] (2020). Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model. PLoS Genetics. ISSN 1553-7390. doi: 10.1371/journal.pgen.1008612. Full text in Research Archive
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  • Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag & Barch, Deanna M. [Show all 76 contributors for this article] (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17376-1. Full text in Research Archive
  • Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng & Alnæs, Dag [Show all 40 contributors for this article] (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–8. doi: 10.1038/s41380-020-0664-1. Full text in Research Archive
  • van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey A.; Devor, Anna & Smeland, Olav Bjerkehagen [Show all 12 contributors for this article] (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications. ISSN 2041-1723. 11:3512, p. 1–9. doi: 10.1038/s41467-020-17368-1.
  • Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen & Frei, Oleksandr [Show all 22 contributors for this article] (2020). Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci. Biological Psychiatry. ISSN 0006-3223. 89(3), p. 227–235. doi: 10.1016/j.biopsych.2020.01.026. Full text in Research Archive
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Dale, Anders & Andreassen, Ole Andreas (2020). The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology. Nature Reviews Neurology. ISSN 1759-4758. p. 1–14. doi: 10.1038/s41582-020-0364-0.
  • Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey A.; O`Connell, Kevin; Frei, Oleksandr & Bettella, Francesco [Show all 13 contributors for this article] (2020). Shared genetic loci between body mass index and major psychiatric disorders: A genome-wide association study. JAMA psychiatry. ISSN 2168-6238. 77(5), p. 503–512. doi: 10.1001/jamapsychiatry.2019.4188.
  • van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Chen, Chi-Hua; Thompson, Wesley K. & O'Connell, Kevin S. [Show all 11 contributors for this article] (2020). Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area. Cerebral Cortex. ISSN 1047-3211. 30(10), p. 5597–5603. doi: 10.1093/cercor/bhaa146. Full text in Research Archive
  • Lam, Max; Awasthi, Swapnil; Watson, Hunna J.; Goldstein, Jackie; Panagiotaropoulou, Georgia & Trubetskoy, Vassily [Show all 22 contributors for this article] (2019). RICOPILI: Rapid Imputation for COnsortias PIpeLIne. Bioinformatics. ISSN 1367-4803. 36(3), p. 930–933. doi: 10.1093/bioinformatics/btz633. Full text in Research Archive
  • O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr & Bettella, Francesco [Show all 24 contributors for this article] (2019). Identification of genetic loci shared between ADHD, intelligence and educational attainment . Biological Psychiatry. ISSN 0006-3223. 87(12), p. 1052–1062. doi: 10.1016/j.biopsych.2019.11.015. Full text in Research Archive
  • Watanabe, Kyoko; Stringer, Sven; Frei, Oleksandr; Mirkov, Maša Umićević; de Leeuw, Christiaan & Polderman, Tinca J.C. [Show all 10 contributors for this article] (2019). A global overview of pleiotropy and genetic architecture in complex traits. Nature Genetics. ISSN 1061-4036. 51(9), p. 1339–1348. doi: 10.1038/s41588-019-0481-0.
  • O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Frei, Oleksandr [Show all 20 contributors for this article] (2019). Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Molecular Psychiatry. ISSN 1359-4184. p. 1–11. doi: 10.1038/s41380-019-0613-z. Full text in Research Archive
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Fan, Chun Chieh & Bahrami, Shahram [Show all 11 contributors for this article] (2019). Discovery of shared genomic loci using the conditional false discovery rate approach. Human Genetics. ISSN 0340-6717. p. 1–10. doi: 10.1007/s00439-019-02060-2. Full text in Research Archive
  • Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders & Andreassen, Ole Andreas (2019). The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges. Psychiatric Genetics. ISSN 0955-8829. 29(5), p. 152–159. doi: 10.1097/YPG.0000000000000234. Full text in Research Archive
  • Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh & Mæland, Steffen [Show all 12 contributors for this article] (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10310-0. Full text in Research Archive
  • Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree & Frei, Oleksandr [Show all 52 contributors for this article] (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience. ISSN 1662-4548. 13. doi: 10.3389/fnins.2019.00220. Full text in Research Archive

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  • Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey & Parker, Nadine [Show all 20 contributors for this article] (2024). Corrigendum to “Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders” [Psychoneuroendocrinology 157 (2023) 106368] (Psychoneuroendocrinology (2023) 157, (S0306453023003463), (10.1016/j.psyneuen.2023.106368)). Psychoneuroendocrinology. ISSN 0306-4530. doi: 10.1016/j.psyneuen.2024.106980.
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  • Akdeniz, Bayram Cevdet ; Mattingsdal, Morten; Dominguez Valentin, Mev; Frei, Oleksandr; Shadrin, Alexey & Puustusmaa, Mikk [Show all 11 contributors for this article] (2022). Implementation of polygenic risk score guided breast cancer prediction in Norwegian data. NSHG-PM 2022.
  • Corfield, Elizabeth Claire; Shadrin, Alexey; Frei, Oleksandr; Rahman, Zillur; Lin, Aihua & Athanasiu, Lavinia [Show all 15 contributors for this article] (2022). Genetic profile of the Norwegian Mother, Father, and Child Cohort Study (MoBa): Results from the MoBaPsychGen pipeline.
  • Corfield, Elizabeth Claire; Frei, Oleksandr; Shadrin, Alexey; Rahman, Zillur; Lin, Aihua & Athanasiu, Lavinia [Show all 26 contributors for this article] (2022). The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: the MoBaPsychGen_v1 pipeline.
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  • Maximov, Ivan; van der Meer, Dennis; de Lange, Ann-Marie Glasø; Kaufmann, Tobias; Shadrin, Alexey & Frei, Oleksandr [Show all 8 contributors for this article] (2021). YTTRIUM: QC algorithm for the processed diffusion maps in UK Biobank 18608 sample.
  • van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey; Devor, Anna & Smeland, Olav Bjerkehagen [Show all 12 contributors for this article] (2020). Author Correction: Understanding the genetic determinants of the brain with MOSTest (Nature Communications, (2020), 11, 1, (3512), 10.1038/s41467-020-17368-1). Nature Communications. ISSN 2041-1723. 11(1). doi: 10.1038/s41467-020-18628-w.
  • Watanabe, Kyoko; Stringer, Sven; Frei, Oleksandr; Mirkov, Maša Umićević; de Leeuw, Christiaan & Polderman, Tinca J. C. [Show all 10 contributors for this article] (2020). Author Correction: A global overview of pleiotropy and genetic architecture in complex traits (Nature Genetics, (2019), 51, 9, (1339-1348), 10.1038/s41588-019-0481-0). Nature Genetics. ISSN 1061-4036. 52(3). doi: 10.1038/s41588-019-0571-z.
  • Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin & Savage, Jeanne [Show all 15 contributors for this article] (2019). Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence (Molecular Psychiatry, (2020), 25, 4, (844-853), 10.1038/s41380-018-0332-x). Molecular Psychiatry. ISSN 1359-4184. 25(4), p. 914–914. doi: 10.1038/s41380-019-0456-7.
  • Corfield, Elizabeth Claire; Frei, Oleksandr; Shadrin, Alexey; Rahman, Zillur; Lin, Aihua & Athanasiu, Lavinia [Show all 26 contributors for this article] (2022). The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1. Cold Spring Harbor Laboratory Press (CSHL). ISSN 2692-8205. (2022).

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Published June 7, 2016 8:55 AM - Last modified Apr. 5, 2018 5:19 PM

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