About the group
The group focuses on interdisciplinary research within the field of diseases of esophagus and stomach. A large biobank of samples from cancer in esophagus and stomach is established in cooperation with the Section for molecular oncology (Prof. Guro Lund).
Projects and Research
- Establishment of a national database and biobank for patients resected for esophageal cancer as part of the NORECa project (Norwegian Esophageal Expert Consortium).
- Total histopathologic response after neoadjuvant chemo(radio)therapy for esophageal cancer -patient characteristics, diagnostics and survival. National study.
- Prediction of postoperative outcome in esophageal cancer with body composition estimates based on AI-segmentation of preoperative CT.
- Monitoring complications/survival after resection for esophageal- and gastric cancer – local registry.
- Continuous local biobanking (blood/tumor tissue) for esophageal cancer, by now some 550 esophageal cancer patients and some 330 gastric cancer patients.
- Studies on esophageal cancer on biomarkers /local treatment of dysplasia and early cancer.
- INTENSE study. Effect of perioperative chemotherapy (FOLFIXFLIRIx4x2) in patients with resectable gastric and gastroesophageal junction adenocarcinoma.
- NEEDS study. Neoadjuvant chemoradiotherapy for squamous cell carcinoma of the esophagus versus definitive chemoradiotherapy with salvage surgery as needed. Multicenter study started in 2021.
- VESTIGE study. Postoperative Immunotherapy vs. Standard chemotherapy for gastric cancer stage Ib-IVb, including esophagogastric junction adenocarcinoma, with high risk for recurrence.
- The upper GI International Robotic Association (UGIRA) - International Registry for Robot-Assisted Minimally Gastrectomy and Esophagectomy (RAMIG and RAMIE) for cancer.
- kiNETiC study – a Scandinavian Randomized Controlled Trial- Ng-tube post–EsophagecTomy.
- Nordic NEC registry (neuroendocrine carcinoma of the GI-tract (GEP-NEC)) (NNTG).
PhD projects 2022
Ingrid Vikan Sjurgard: “Molecular- and immuno-profiling of esophageal adenocarcinoma”.
Tobias Hauge: “Esophageal Cancer and Barrett’s Esophagus Targeted molecular profiling and long-term outcome following minimally invasive esophagectomy and endoscopic treatment”.
Student projects
Hiatal gastroesophageal hernia – treatment at OUS, Ullevål – retrospective cohort study.
Cooperation
Internal
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Truls Hauge and colleagues at Dep. Gastroenterology, OUS, Ullevål
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Geir Olav Hjortland and colleagues at the Dep. Oncology, OUS, Ullevål
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Guro E. Lind and colleagues at Dep. of Molecular Oncology, Institute of Cancer Research, OUS, DNR.
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Colleagues at the university clinics in Tromsø, Trondheim and Bergen
International
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Magnus Nilsson and colleagues at the Dep. Upper GI surgery, Karolinska University Hospital, Sweden
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Jacob Hedberg, Dep. Surgical Sciences, Uppsala, Sweden
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C. de Jongh, University Medical Center, Utrecht, Netherlands
Selected Publications
- A national precision cancer medicine implementation initiative for Norway. Taskén K, et al. Nat Med. 2022.
- Short- and long-term outcomes in patients operated with total minimally invasive esophagectomy for esophageal cancer. Hauge T, et al. Dis Esophagus. 2022.
- Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed: The Study Protocol for the Randomized Controlled NEEDS Trial. Nilsson M, et al. Front Oncol. 2022.
- Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway. Helland Å et al. J Transl Med. 2022.
- Volumetric parameters from [18 F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms. Stokmo HL, J Neuroendocrinol. 2022.
- Predicting satisfaction with outcome and follow-up care 5 years after bariatric surgery: A prospective evaluation. Kvalem IL, et al. Obes Sci Pract. 2022.
- Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett's esophagus. Pinto R, et al. Clin Epigenetics. 2022.
- Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy. Evensen H, et al. Endosc Int Open. 2022.
- Early experience with total robotic D2 gastrectomy in a low incidence region: surgical perspectives. Mala T, et al.. BMC Surg. 2022.
- International variation in oesophageal and gastric cancer survival 2012-2014: differences by histological subtype and stage at diagnosis (an ICBP SURVMARK-2 population-based study). Arnold M, et al. Gut. 2022.
- Partial splenectomy after preoperative embolization in a patient with metastatic melanoma - A case report. Hauge T, et al. Int J Surg Case Rep. 2022.
- Gastroscopy following vertical sleeve gastrectomy. Mala T et al. Tidsskr Nor Laegeforen. 2022.