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Diseases of esophagus and stomach

The group includes members with expertise within surgery, oncology, pathology and translational research working for improvement of diagnostics and treatment of diseases of the esophagus and stomach.

About the group

The group focuses on interdisciplinary research within the field of diseases of esophagus and stomach. A large biobank of samples from cancer in esophagus and stomach is established in cooperation with the Section for molecular oncology (Prof. Guro Lund).

Projects and Research

  • Establishment of a national database and biobank for patients resected for esophageal cancer as part of the NORECa project (Norwegian Esophageal Expert Consortium).
  • Total histopathologic response after neoadjuvant chemo(radio)therapy for esophageal cancer  -patient characteristics, diagnostics and survival. National study.
  • Prediction of postoperative outcome in esophageal cancer with body composition estimates based on AI-segmentation of preoperative CT.
  • Monitoring complications/survival after resection for esophageal- and gastric cancer – local registry.
  • Continuous local biobanking (blood/tumor tissue) for esophageal cancer, by now some 550 esophageal cancer patients and some 330 gastric cancer patients. 
  • Studies on esophageal cancer on biomarkers /local treatment of dysplasia and early cancer.
  • INTENSE study.  Effect of perioperative chemotherapy (FOLFIXFLIRIx4x2) in patients with resectable gastric and gastroesophageal junction adenocarcinoma.
  • NEEDS study. Neoadjuvant chemoradiotherapy for squamous cell carcinoma of the esophagus versus definitive chemoradiotherapy with salvage surgery as needed. Multicenter study started in 2021.
  • VESTIGE study. Postoperative Immunotherapy vs. Standard chemotherapy for gastric cancer stage Ib-IVb, including esophagogastric junction adenocarcinoma, with high risk for recurrence.
  • The upper GI International Robotic Association (UGIRA) - International Registry for Robot-Assisted Minimally Gastrectomy and Esophagectomy (RAMIG and RAMIE) for cancer.
  • kiNETiC study – a Scandinavian Randomized Controlled Trial- Ng-tube post–EsophagecTomy. 
  • Nordic NEC registry (neuroendocrine carcinoma of the GI-tract (GEP-NEC)) (NNTG).

PhD projects 2022

Ingrid Vikan Sjurgard: “Molecular- and immuno-profiling of esophageal adenocarcinoma”.

Tobias Hauge: “Esophageal Cancer and Barrett’s Esophagus Targeted molecular profiling and long-term outcome following minimally invasive esophagectomy and endoscopic treatment”.

Student projects

Hiatal gastroesophageal hernia – treatment at OUS, Ullevål – retrospective cohort study.

Cooperation

Internal

  • Truls Hauge and colleagues at Dep. Gastroenterology, OUS, Ullevål

  • Geir Olav Hjortland and colleagues at the Dep. Oncology, OUS, Ullevål

  • Guro E. Lind and colleagues at Dep. of Molecular Oncology, Institute of Cancer Research, OUS, DNR.  

  • Colleagues at the university clinics in Tromsø, Trondheim and Bergen

International

  • Magnus Nilsson and colleagues at the Dep. Upper GI surgery, Karolinska University Hospital, Sweden

  • Jacob Hedberg, Dep. Surgical Sciences, Uppsala, Sweden

  • C. de Jongh, University Medical Center, Utrecht, Netherlands

Selected Publications

  • A national precision cancer medicine implementation initiative for Norway. Taskén K, et al. Nat Med. 2022.
  • Short- and long-term outcomes in patients operated with total minimally invasive esophagectomy for esophageal cancer. Hauge T, et al. Dis Esophagus. 2022.
  • Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed: The Study Protocol for the Randomized Controlled NEEDS Trial. Nilsson M, et al. Front Oncol. 2022.
  • Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway. Helland Å et al. J Transl Med. 2022.
  • Volumetric parameters from [18 F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms. Stokmo HL, J Neuroendocrinol. 2022.
  • Predicting satisfaction with outcome and follow-up care 5 years after bariatric surgery: A prospective evaluation. Kvalem IL, et al. Obes Sci Pract. 2022.
  • Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett's esophagus. Pinto R, et al. Clin Epigenetics. 2022.
  • Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy. Evensen H, et al. Endosc Int Open. 2022.
  • Early experience with total robotic D2 gastrectomy in a low incidence region: surgical perspectives. Mala T, et al.. BMC Surg. 2022.
  • International variation in oesophageal and gastric cancer survival 2012-2014: differences by histological subtype and stage at diagnosis (an ICBP SURVMARK-2 population-based study). Arnold M, et al. Gut. 2022.
  • Partial splenectomy after preoperative embolization in a patient with metastatic melanoma - A case report. Hauge T, et al. Int J Surg Case Rep. 2022.
  • Gastroscopy following vertical sleeve gastrectomy. Mala T et al. Tidsskr Nor Laegeforen. 2022.

 

Published Aug. 10, 2018 10:33 AM - Last modified Sep. 27, 2023 1:38 PM

Contact

Group Leader

Participants

  • Tom Mala Universitetet i Oslo
  • Egil Johnson Universitetet i Oslo
  • Hans-Olaf Johannessen
  • Dag T. Førland
  • Caroline Ursin Skagemo
  • Geir Olav Hjortland
  • Al-Haidari Ghazwan
  • Brit Dybdahl
  • Theresa Kumar
  • Magnus Fasting
  • Torgeir Thorson Søvik
  • Helene Marie Haug
  • Tobias Hauge
  • Thomas Dretvik
Detailed list of participants