Dennis van der Meer

• Maximov, Ivan; van der Meer, Dennis; de Lange, Ann-Marie Glasø; Kaufmann, Tobias; Shadrin, Alexey A.; Frei, Oleksandr; Wolfers, Thomas & Westlye, Lars Tjelta (2021). Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: U.K. Biobank 18,608 example. Human Brain Mapping.  ISSN 1065-9471. . doi: https://doi.org/10.1002/hbm.25424
• Roelfs, Daniel; Alnæs, Dag; Frei, Oleksandr; van der Meer, Dennis; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry.  ISSN 2158-3188.  11(1) . doi: 10.1038/s41398-021-01313-x Fulltekst i vitenarkiv. Vis sammendrag

  Genome-wide association studies (GWAS) and family-based studies have revealed partly overlapping genetic architectures between various psychiatric disorders. Given clinical overlap between disorders, our knowledge of the genetic architectures underlying specific symptom profiles and risk factors is limited. Here, we aimed to derive distinct profiles relevant to mental health in healthy individuals and to study how these genetically relate to each other and to common psychiatric disorders. Using independent component analysis, we decomposed self-report mental health questionnaires from 136,678 healthy individuals of the UK Biobank, excluding data from individuals with a diagnosed neurological or psychiatric disorder, into 13 distinct profiles relevant to mental health, capturing different symptoms as well as social and risk factors underlying reduced mental health. Utilizing genotypes from 117,611 of those individuals with White British ancestry, we performed GWAS for each mental health profile and assessed genetic correlations between these profiles, and between the profiles and common psychiatric disorders and cognitive traits. We found that mental health profiles were genetically correlated with a wide range of psychiatric disorders and cognitive traits, with strongest effects typically observed between a given mental health profile and a disorder for which the profile is common (e.g. depression symptoms and major depressive disorder, or psychosis and schizophrenia). Strikingly, although the profiles were phenotypically uncorrelated, many of them were genetically correlated with each other. This study provides evidence that statistically independent mental health profiles partly share genetic underpinnings and show genetic overlap with psychiatric disorders, suggesting that shared genetics across psychiatric disorders cannot be exclusively attributed to the known overlapping symptomatology between the disorders.

• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 8 . doi: 10.1038/s41380-020-0664-1 Fulltekst i vitenarkiv.
• de Lange, Ann-Marie Glasø; Barth, Claudia; Kaufmann, Tobias; Maximov, Ivan; van der Meer, Dennis; Agartz, Ingrid & Westlye, Lars Tjelta (2020). Women's brain aging: effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer's disease. Human Brain Mapping.  ISSN 1065-9471.  s 1- 10 . doi: 10.1002/hbm.25180 Fulltekst i vitenarkiv.
• Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O`Connell, Kevin; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Sowa, Piotr; Soininen, Hilkka; Steen, Vidar Martin; Vellas, Bruno; Tsolaki, Magda; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications.  ISSN 2041-1723.  11 . doi: 10.1038/s41467-020-17376-1 Fulltekst i vitenarkiv. Vis sammendrag

  Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita; Hibar, DP; Lind, Penelope A.; Pizzagalli, Fabrizio; Ching, Christopher R.K.; McMahon, Mary Agnes B.; Shatokhina, Natalia; Zsembik, Leo C.P.; Thomopoulos, Sophia I.; Zhu, Alyssa H.; Strike, Lachlan T.; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Wolfers, Thomas; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Melle, Ingrid; Andreassen, Ole Andreas; Espeseth, Thomas; Jönsson, Erik Gunnar; Steen, Vidar Martin; Håberg, Asta; Trollor, Julian N.; Van Der Wee, Nic J.A.; Volzke, Henry; Walter, Henrik; Weber, Bernd; Weinberger, Daniel R.; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). The genetic architecture of the human cerebral cortex. Science.  ISSN 0036-8075.  367(6484) . doi: 10.1126/science.aay6690 Fulltekst i vitenarkiv. Vis sammendrag

  INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.

• Haukvik, Unn Kristin H.; Gurholt, Tiril Pedersen; Nerland, Stener; Elvsåshagen, Torbjørn; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T.; Benedetti, Francesco; Berk, Michael; Bettella, Francesco; Bøen, Erlend; Bonnín, Caterina M.; Brambilla, Paolo; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Dandash, Orwa; Dannlowski, Udo; Delvecchio, Giuseppe; Díaz-Zuluaga, Ana M.; van Erp, Theo G.M.; Fatjó-Vilas, Mar; Foley, Sonya F.; Förster, Katharina; Fullerton, Janice M.; Goikolea, Jose M.; Grotegerd, Dominik; Gruber, Oliver; Haarman, Bartholomeus C. M.; Haatveit, Beathe; Hajek, Tomas; Hallahan, Brian; Harris, Mathew; Hawkins, Emma L.; Howells, Fleur M.; Hülsmann, Carina; Jahanshad, Neda; Jørgensen, Kjetil Nordbø; Kircher, Tilo; Krämer, Bernd; Krug, Axel; Kuplicki, Rayus; Lagerberg, Trine Vik; Lancaster, Thomas M.; Lenroot, Rhoshel K.; Lonning, Vera Louise Hiorth; López-Jaramillo, Carlos; Malt, Ulrik Fredrik; McDonald, Colm; McIntosh, Andrew M.; McPhilemy, Genevieve; van der Meer, Dennis; Melle, Ingrid; Melloni, Elisa M. T.; Mitchell, Philip B.; Nabulsi, Leila; Nenadic, Igor; Oertel, Viola; Oldani, Lucio; Opel, Nils; Otaduy, Maria C. G.; Overs, Bronwyn; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Radua, Joaquim; Rauer, Lisa; Redlich, Ronny; Repple, Jonathan; Rive, Maria M.; Roberts, Gloria; Ruhe, Henricus G.; Salminen, Lauren E.; Salvador, Raymond; Sarró, Salvador; Savitz, Jonathan; Schene, Aart H.; Sim, Kang; Soeiro-de-Souza, Marcio G.; Stäblein, Michael; Stein, Dan J.; Stein, Frederike; Tamnes, Christian Krog; Temmingh, Henk S.; Thomopoulos, Sophia I.; Veltman, Dick J.; Vieta, Eduard; Waltemate, Lena; Westlye, Lars Tjelta; Whalley, Heather C.; Sämann, Philipp G.; Thompson, Paul M.; Ching, Christopher; Andreassen, Ole Andreas & Agartz, Ingrid (2020). In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group. Human Brain Mapping.  ISSN 1065-9471.  s 1- 14 . doi: 10.1002/hbm.25249 Fulltekst i vitenarkiv.
• Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Panizzon, Matthew S.; Andreassen, Ole Andreas; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Ikram, M. Arfan; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Melle, Ingrid; Nordvik, Jan Egil; Steen, Vidar Martin; Espeseth, Thomas; Håberg, Asta; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications.  ISSN 2041-1723.  11 . doi: 10.1038/s41467-020-18367-y Fulltekst i vitenarkiv.
• Leu, Costin; Richardson, Tom G.; Kaufmann, Tobias; van der Meer, Dennis; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Busch, Robyn M.; Smith, George Davey & Lal, Dennis (2020). Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population. PLOS ONE.  ISSN 1932-6203.  15(4) . doi: 10.1371/journal.pone.0232292 Fulltekst i vitenarkiv.
• Lund, Martina Jonette; Alnæs, Dag; Schwab, Simon; van der Meer, Dennis; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2020). Differences in directed functional brain connectivity related to age, sex and mental health. Human Brain Mapping.  ISSN 1065-9471.  41(15), s 4173- 4186 . doi: 10.1002/hbm.25116 Fulltekst i vitenarkiv.
• Meijer, Mandy; Klein, Marieke; Hannon, Eilis; van der Meer, Dennis; Hartman, Catharina A.; Oosterlaan, Jaap; Heslenfeld, Dirk J.; Hoekstra, Pieter J.; Buitelaar, Jan; Mill, Jonathan & Franke, Barbara (2020). Genome-Wide DNA Methylation Patterns in Persistent Attention-Deficit/Hyperactivity Disorder and in Association With Impulsive and Callous Traits. Frontiers in Genetics.  ISSN 1664-8021.  11, s 1- 10 . doi: 10.3389/fgene.2020.00016 Fulltekst i vitenarkiv.
• Mufford, Mary S; van der Meer, Dennis; Andreassen, Ole Andreas; Ramesar, Raj; Stein, Dan J. & Dalvie, Shareefa (2020). A review of systems biology research of anxiety disorders. Revista Brasileira de Psiquiatria.  ISSN 1516-4446. . doi: 10.1590/1516-4446-2020-1090 Fulltekst i vitenarkiv.
• Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Doan, Nhat Trung; Moberget, Torgeir; Kaufmann, Tobias; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2020). Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents. Translational Psychiatry.  ISSN 2158-3188.  10(251) . doi: 10.1038/s41398-020-00931-1 Fulltekst i vitenarkiv.
• Openneer, Thaïra J.C.; Marsman, Jan-Bernard C.; van der Meer, Dennis; Forde, Natalie J.; Akkermans, Sophie E.A.; Naaijen, Jilly; Buitelaar, Jan; Dietrich, Andrea & Hoekstra, Pieter J. (2020). A graph theory study of resting-state functional connectivity in children with Tourette syndrome. Cortex.  ISSN 0010-9452.  126, s 63- 72 . doi: 10.1016/j.cortex.2020.01.006 Fulltekst i vitenarkiv.
• Openneer, Thaïra J.C.; van der Meer, Dennis; Marsman, Jan-Bernard C.; Forde, Natalie J.; Akkermans, Sophie E.A.; Naaijen, Jilly; Buitelaar, Jan K.; Hoekstra, Pieter J. & Dietrich, Andrea (2020). Impaired response inhibition during a stop-signal task in children with Tourette syndrome is related to ADHD symptoms: A functional magnetic resonance imaging study. World Journal of Biological Psychiatry.  ISSN 1562-2975. . doi: 10.1080/15622975.2020.1813329 Fulltekst i vitenarkiv.
• Tesli, Natalia; van der Meer, Dennis; Rokicki, Jaroslav; Storvestre, Guttorm Breivik; Røsæg, Cato; Jensen, Arvid; Hjell, Gabriela; Bell, Christina; Fischer-Vieler, Thomas; Tesli, Martin Steen; Andreassen, Ole Andreas; Melle, Ingrid; Agartz, Ingrid & Haukvik, Unn Kristin H. (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334. . doi: 10.1007/s00406-020-01098-y Fulltekst i vitenarkiv.
• Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Doan, Nhat Trung; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  5(12), s 1095- 1103 . doi: 10.1016/j.bpsc.2020.06.014 Fulltekst i vitenarkiv.
• van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Chen, Chi-Hua; Thompson, Wesley K.; O'Connell, Kevin S.; Monereo Sanchez, Jennifer; Linden, David E.J.; Westlye, Lars Tjelta; Dale, Anders M & Andreassen, Ole Andreas (2020). Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area. Cerebral Cortex.  ISSN 1047-3211.  30(10), s 5597- 5603 . doi: 10.1093/cercor/bhaa146 Fulltekst i vitenarkiv.
• van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey A.; Devor, Anna; Smeland, Olav Bjerkehagen; Thompson, Wesley Kurt; Fan, Chun Chieh; Holland, Dominic; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Dale, Anders (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications.  ISSN 2041-1723.  11:3512, s 1- 9 . doi: 10.1038/s41467-020-17368-1
• van der Meer, Dennis; Pinzón-Espinosa, Justo; Lin, Bochao Danae; Tijdink, Joeri K.; Vinkers, Christiaan H.; Guloksuz, Sinan & Luykx, Jurjen J. (2020). Associations between psychiatric disorders, COVID-19 testing probability and COVID-19 testing results: findings from a population-based study. BJPsych Open.  ISSN 2056-4724.  6(5) . doi: 10.1192/bjo.2020.75 Fulltekst i vitenarkiv.
• Wierenga, Lara M.; Doucet, Gaëlle E.; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N.; Albajes-Eizagirre, Anton; Alnæs, Dag; Alpert, Kathryn I.; Andreassen, Ole Andreas; Anticevic, Alan; Gurholt, Tiril Pedersen; De Haan, Lieuwe; Haatveit, Beathe Christin; Jönsson, Erik Gunnar; Joska, John; Kalnin, Andrew J.; Klein, Marieke; Koenders, Laura; Kolskår, Knut-Kristian; van der Meer, Dennis; Menchon, José M.; Naaijen, Jilly; Nyberg, Lars; Oosterlaan, Jaap; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J.; Radua, Joaquim; Reif, Andreas; Richard, Geneviéve´; Weber, Bernd; Wen, Wei; West, John D.; Westlye, Lars Tjelta; Whalley, Heather C.; Williams, Steven Charles Rees; Wittfeld, Katharina; Wolf, Daniel H.; Wright, Margaret J.; Yoncheva, Yuliya N.; Zanetti, Marcus V.; Ziegler, Georg C.; de Zubicaray, Greig I.; Thompson, Paul M.; Crone, Eveline A.; Frangou, Sophia & Tamnes, Christian Krog (2020). Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping.  ISSN 1065-9471. . doi: 10.1002/hbm.25204 Fulltekst i vitenarkiv.
• Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry.  ISSN 2158-3188.  9 . doi: 10.1038/s41398-019-0432-7 Fulltekst i vitenarkiv.
• Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav; Moberget, Torgeir; Bettella, Francesco; Agartz, Ingrid; Barch, Deanna M.; Bertolino, Alessandro; Brandt, Christine Lycke; Cervenka, Simon; Djurovic, Srdjan; Doan, Nhat Trung; Eisenacher, Sarah; Fatouros-Bergman, Helena; Flyckt, Lena; di Giorgio, Annabella; Haatveit, Beathe; Jönsson, Erik Gunnar; Kirsch, Peter; Lund, Martina Jonette; Meyer-Lindenberg, Andreas; Pergola, Giulio; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Quarto, Tiziana; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry.  ISSN 2168-6238.  76(7), s 739- 748 . doi: 10.1001/jamapsychiatry.2019.0257
• de Lange, Ann-Marie Glasø; Kaufmann, Tobias; van der Meer, Dennis; Maglanoc, Luigi Angelo; Alnæs, Dag; Moberget, Torgeir; Douaud, Gwenaëlle; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Population-based neuroimaging reveals traces of childbirth in the maternal brain. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  116(44), s 22341- 22346 . doi: 10.1073/pnas.1910666116
• Izzo, Jessica; Andreassen, Ole Andreas; Westlye, Lars Tjelta & van der Meer, Dennis (2019). The association between hippocampal subfield volumes in mild cognitive impairment and conversion to Alzheimer’s disease. Brain Research.  ISSN 0006-8993.  s 1- 7 . doi: 10.1016/j.brainres.2019.146591
• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience.  ISSN 1097-6256.  22(10), s 1617- 1623 . doi: 10.1038/s41593-019-0471-7 Fulltekst i vitenarkiv.
• Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Brain connectome mapping of complex human traits and their polygenic architecture using machine learning. Biological Psychiatry.  ISSN 0006-3223.  s 1- 10 . doi: 10.1016/j.biopsych.2019.10.011 Fulltekst i vitenarkiv. Vis sammendrag

  Background Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and substantial clinical overlap. Brain network analysis provides a non-invasive means of dissecting biological heterogeneity yet its sensitivity, specificity and validity in assessing individual characteristics relevant for brain function and mental health and their genetic underpinnings in clinical applications remains a challenge. Methods In a machine learning approach, we predicted individual scores for educational attainment, fluid intelligence and dimensional measures of depression, anxiety and neuroticism using fMRI-based static and dynamic temporal synchronization between large-scale brain network nodes in 10,343 healthy individuals from the UK Biobank. In addition to age and sex to serve as our reference point, we also predicted individual polygenic scores for related phenotypes, and 13 different neuroticism traits and schizophrenia. Results Beyond high accuracy for age and sex, supporting the biological sensitivity of the connectome-based features, permutation tests revealed above chance-level prediction accuracy for trait-level educational attainment and fluid intelligence. Educational attainment and fluid intelligence were mainly negatively associated with static brain connectivity in frontal and default mode networks, whereas age showed positive correlations with a more widespread pattern. In contrast, prediction accuracy was at chance level for depression, anxiety, neuroticism and polygenic scores across traits. Conclusion These novel findings provide a benchmark for future studies linking the genetic architecture of individual and mental health traits with fMRI-based brain connectomics.

• Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics. Nature Neuroscience.  ISSN 1097-6256. . doi: 10.1101/609586
• Moberget, Torgeir; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry.  ISSN 0006-3223.  86(1), s 65- 75 . doi: 10.1016/j.biopsych.2019.01.019 Fulltekst i vitenarkiv.
• Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo; Dieset, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Oxytocin pathway gene networks in the human brain. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-08503-8 Fulltekst i vitenarkiv.
• Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J.; Stein, Jason L.; Scholz, Markus; Sargurupremraj, Muralidharan; Jahanshad, Neda; Roshchupkin, Gennady V.; Smith, Albert V.; Bis, Joshua C.; Jian, Xueqiu; Luciano, Michelle; Hofer, Edith; Teumer, Alexander; van der Lee, Sven J.; Yang, Jingyun; Yanek, Lisa R.; Lee, Tom V.; Li, Shuo; Hu, Yanhui; Koh, Jia Yu; Eicher, John D.; Desrivières, Sylvane; Arias-Vasquez, Alejandro; Chauhan, Ganesh; Athanasiu, Lavinia; Rentería, Miguel E.; Kim, Sungeun; Hoehn, David; Armstrong, Nicola J.; Chen, Qiang; Holmes, Avram J.; den Braber, Anouk; Kloszewska, Iwona; Andersson, Micael; Espeseth, Thomas; Grimm, Oliver; Abramovic, Lucija; Alhusaini, Saud; Milaneschi, Yuri; Papmeyer, Martina; Axelsson, Tomas; Ehrlich, Stefan; Roiz-Santiáñez, Roberto; Kraemer, Bernd; Håberg, Asta; Jones, Hannah J; Pike, G. Bruce; Stein, Dan J.; Stevens, Allison; Bralten, Janita; Vernooij, Meike W.; Harris, Tamara B.; Filippi, Irina; Witte, A Veronica; Guadalupe, Tulio; Wittfeld, Katharina; Mosley, Thomas H.; Becker, James T.; Hagenaars, Saskia P.; Saba, Yasaman; Cuellar-Partida, Gabriel; Amin, Najaf; Hilal, Saima; Nho, Kwangsik; Mirza-Schreiber, Nazanin; Arfanakis, Konstantinos; Becker, Diane M.; Ames, David; Goldman, Aaron L.; Lee, Phil H.; Boomsma, Dorret I.; Lovestone, Simon; Giddaluru, Sudheer; Le Hellard, Stephanie; Mattheisen, Manuel; Bohlken, Marc M.; Kasperaviciute, Dalia; Schmaal, Lianne; Lawrie, Stephen M.; Agartz, Ingrid; Walton, Esther; Tordesillas-Gutierrez, Diana; Davies, Gareth E.; Shin, Jean; Ipser, Jonathan C.; Vinke, Louis N.; Hoogman, Martine; Jia, Tianye; Burkhardt, Ralph; Klein, Marieke; Crivello, Fabrice; Janowitz, Deborah; Carmichael, Owen; Haukvik, Unn Kristin H.; Aribisala, Benjamin S.; Schmidt, Helena; Strike, Lachlan T.; Cheng, Ching-Yu; Risacher, Shannon L.; Putz, Benno; Fleischman, Debra A.; Assareh, Amelia A.; Mattay, Venkata S.; Buckner, Randy L.; Mecocci, Patrizia; Dale, Anders; Cichon, Sven; Boks, Marco P.; Matarin, Mar; Penninx, Brenda W.J.H.; Calhoun, Vince D.; Chakravarty, M. Mallar; Marquand, André F.; Macare, Christine; Kharabian Masouleh, Shahrzad; Oosterlaan, Jaap; Amouyel, Philippe; Hegenscheid, Katrin; Rotter, Jerome I.; Schork, Andrew J.; Liewald, David C.M.; de Zubicaray, Greig I.; Wong, Tien Yin; Shen, Li; Sämann, Philipp G.; Brodaty, Henry; Roffman, Joshua L.; de Geus, Eco J.C.; Tsolaki, Magda; Erk, Susanne; van Eijk, Kristel R.; Cavalleri, Gianpiero L.; Van Der Wee, Nic J.A.; McIntosh, Andrew M.; Gollub, Randy L.; Bulayeva, Kazima B.; Bernard, Manon; Richards, Jennifer S.; Himali, Jayandra J.; Loeffler, Markus; Rommelse, Nanda; Hoffmann, Wolfgang; Westlye, Lars Tjelta; Valdés Hernández, Maria C.; Hansell, Narelle K.; van Erp, Theo G.M.; Wolf, Christiane; Kwok, John B.J.; Vellas, Bruno; Heinz, Andreas; Olde Loohuis, Loes M.; Delanty, Norman; Ho, Beng-Choon; Ching, Christopher R.K.; Shumskaya, Elena; Singh, Baljeet; Hofman, Albert; Homuth, Georg; Psaty, Bruce M.; Bastin, Mark E.; Montgomery, Grant W.; Foroud, Tatiana M.; Reppermund, Simone; Hottenga, Jouke-Jan; Simmons, Andrew; Meyer-Lindenberg, Andreas; Cahn, Wiepke; Whelan, Christopher D; van Donkelaar, Marjolein M.J.; Yang, Qiong; Hosten, Norbert; Green, Robert C.; Thalamuthu, Anbupalam; Mohnke, Sebastian; Hulshoff Pol, Hilleke E.; Lin, Honghuang; Jack, Clifford R.; Schofield, Peter R.; Mühleisen, Thomas W.; Maillard, Pauline; Potkin, Steven G.; Wen, Wei; Fletcher, Evan; Toga, Arthur W.; Gruber, Oliver; Huentelman, Matthew; Davey Smith, George; Launer, Lenore J.; Nyberg, Lars; Jönsson, Erik Gunnar; Crespo-Facorro, Benedicto; Koen, Nastassja; Greve, Douglas N.; Uitterlinden, André G.; Weinberger, Daniel R.; Steen, Vidar Martin; Fedko, Iryna O.; Groenewold, Nynke A.; Niessen, Wiro J.; Toro, Roberto; Tzourio, Christophe; Longstreth, William T.; Ikram, M. Kamran; Smoller, Jordan W.; van Tol, Marie-Jose; Sussmann, Jessika E.; Paus, Tomáš; Lemaître, Hervé; Schroeter, Matthias L.; Mazoyer, Bernard; Andreassen, Ole Andreas; Holsboer, Florian; Depondt, Chantal; Veltman, Dick J.; Turner, Jessica A.; Pausova, Zdenka; Schumann, Gunter; van Rooij, Daan; Djurovic, Srdjan; Deary, Ian J.; McMahon, Katie L; Müller-Myhsok, Bertram; Brouwer, Rachel M.; Soininen, Hilkka; Pandolfo, Massimo; Wassink, Thomas H.; Cheung, Joshua W.; Wolfers, Thomas; Martinot, Jean-Luc; Zwiers, Marcel P.; Nauck, Matthias; Melle, Ingrid; Martin, Nicholas G.; Kanai, Ryota; Westman, Eric; Kahn, René S.; Sisodiya, Sanjay M.; White, Tonya; Saremi, Arvin; van Bokhoven, Hans; Brunner, Han G.; Völzke, Henry; Wright, Margaret J.; van `t Ent, Dennis; Nöthen, Markus M.; Ophoff, Roel A.; Buitelaar, Jan K.; Fernandéz, Guillén; Sachdev, Perminder S.; Rietschel, Marcella; van Haren, Neeltje E.M.; Fisher, Simon E.; Beiser, Alexa S.; Francks, Clyde; Saykin, Andrew J.; Mather, Karen A.; Romanczuk-Seiferth, Nina; Hartman, Catharina A.; DeStefano, Anita L; Heslenfeld, Dirk J.; Weiner, Michael W.; Walter, Henrik; Hoekstra, Pieter J.; Nyquist, Paul A.; Franke, Barbara; Bennett, David A.; Grabe, Hans J.; Johnson, Andrew D.; Chen, Christopher; van Duijn, Cornelia M.; Lopez, Oscar L.; Fornage, Myriam; Wardlaw, Joanna M.; Schmidt, Reinhold; DeCarli, Charles; De Jager, Philip L.; Villringer, Arno; Debette, Stéphanie; Gudnason, Vilmundur; Medland, Sarah E.; Shulman, Joshua M.; Thompson, Paul M.; Seshadri, Sudha; Ikram, M. Arfan; Doan, Nhat Trung & van der Meer, Dennis (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics.  ISSN 1061-4036.  51, s 1624- 1636 . doi: 10.1038/s41588-019-0511-y Fulltekst i vitenarkiv. Vis sammendrag

  Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

• van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Cavalleri, Gianpiero L.; Ching, Christopher R.K.; Cichon, Sven; Ciufolini, Simone; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J.C.; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Delanty, Norman; den Braber, Anouk; Desrivieres, Sylvane; di Forti, Marta; Doherty, Joanne L.; Donohoe, Gary; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Håberg, Asta; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek; Hillegers, Manon H.J.; Hoffmann, Per; Holleran, Laurena; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jacquemont, Sébastien; Jahanshad, Neda; Jockwitz, Christiane; Johansson, Stefan; Jönsson, Erik Gunnar; Kikuchi, Masataka; Knowles, Emma E.M.; Kwok, John B.; Le Hellard, Stephanie; Linden, David E.J.; Liu, Jingyu; Lundervold, Arvid; Lundervold, Astri; Martin, Nicholas G.; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Moberget, Torgeir; Moreau, Clara; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nordvik, Jan Egil; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomáš; Pausova, Zdenka; Peralta, Juan M.; Pike, Bruce; Prieto, Carlos; Quinlan, Erin Burke; Reinbold, Céline Sonja; Reis Marques, Tiago; Rucker, James J.H.; Sachdev, Perminder S.; Sando, Sigrid Botne; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Steen, Vidar Martin; Stein, Dan J.; Strike, Lachlan T.; Tamnes, Christian Krog; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ülfarsson, Magnús Ö; van 't Ent, Dennis; van den Bree, Marianne B.M.; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Zayats, Tetyana; Dale, Anders; Djurovic, Srdjan; Agartz, Ingrid; Westlye, Lars Tjelta; Stefansson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry.  ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2019.3779 Vis sammendrag

  IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders

• Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; van der Meer, Dennis; Alnæs, Dag; Rokicki, Jaroslav; Moberget, Torgeir; Sønderby, Ida Elken; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics.  ISSN 1018-4813.  26(7), s 1049- 1059 . doi: 10.1038/s41431-018-0134-2
• Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas; Bøen, Erlend; Còrdova Palomera, Aldo; Dale, Anders; Doan, Nhat Trung; Elvsåshagen, Torbjørn; Faraone, Stephen V.; Gurholt, Tiril Pedersen; Haavik, Jan; Høvik, Marie Farstad; Hugdahl, Kenneth; Jönsson, Erik Gunnar; Lundervold, Astri; Malt, Ulrik Fredrik; Nerland, Stener; Nordvik, Jan Egil; Plessen, Kerstin J.; Smelror, Runar; van den Heuvel, Odile A; van der Meer, Dennis; Lønning, Kjersti; Westlye, Lars Tjelta; Glahn, David C.; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E.; Thompson, Paul M. & Francks, Clyde (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  115(22), s E5154- E5163 . doi: 10.1073/pnas.1718418115
• Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Ueland, Torill; Lagerberg, Trine Vik; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-32355-9 Fulltekst i vitenarkiv.
• van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 13 . doi: 10.1038/s41380-018-0262-7 Fulltekst i vitenarkiv.
• Richards, Jennifer S.; Arias Vasquez, Alejandro; Van Rooij, Daan; van der Meer, Dennis; Franke, Barbara; Hoekstra, Pieter J; Heslenfeld, Dirk J; Oosterlaan, Jaap; Faraone, Stephen V.; Hartman, Catharina A. & Buitelaar, Jan K (2017). Testing differential susceptibility: Plasticity genes, the social environment, and their interplay in adolescent response inhibition. World Journal of Biological Psychiatry.  ISSN 1562-2975.  18(4), s 308- 321 . doi: 10.3109/15622975.2016.1173724
• van der Meer, Dennis; Hartman, Catharina A.; Van Rooij, Daan; Franke, Barbara; Heslenfeld, Dirk J.; Oosterlaan, Jaap; Faraone, Stephen V.; Buitelaar, Jan K. & Hoekstra, Pieter J. (2017). Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition. Journal of Psychiatry & Neuroscience.  ISSN 1180-4882.  42(2), s 113- 121 . doi: 10.1503/jpn.150350
• van der Meer, Dennis; Hoekstra, Pieter J.; van Donkelaar, Marjolein M.J.; Bralten, Janita; Oosterlaan, Jaap; Heslenfeld, Dirk; Faraone, Stephen V.; Franke, Barbara; Buitelaar, Jan K. & Hartman, Catharina A. (2017). Predicting attention-deficit/hyperactivity disorder severity from psychosocial stress and stress-response genes: A random forest regression approach. Translational Psychiatry.  ISSN 2158-3188.  7(6), s 1- 9 . doi: 10.1038/tp.2017.114
• van der Meer, Dennis; Hartman, Catharina A.; Pruim, Raimon H.R.; Mennes, Maarten; Heslenfeld, Dirk; Oosterlaan, Jaap; Faraone, Stephen V.; Franke, Barbara; Buitelaar, Jan K. & Hoekstra, Pieter J. (2016). The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks. Brain Imaging and Behavior.  ISSN 1931-7557.  Published ahead of print, s 1- 11 . doi: 10.1007/s11682-016-9633-3

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