Erik Gunnar Jönsson

• Jørgensen, Kjetil Nordbø; Nerland, Stener; Slapø, Nora Berz; Norbom, Linn Bonaventure; Mørch-Johnsen, Lynn Egeland & Wortinger, Laura Anne [Vis alle 13 forfattere av denne artikkelen] (2024). Assessing regional intracortical myelination in schizophrenia spectrum and bipolar disorders using the optimized T1w/T2w-ratio. Psychological Medicine. ISSN 0033-2917. doi: 10.1017/S0033291724000503.
• Pentz, Atle Bråthen; O'Connell, Kevin Sean; van Jole, Oda; Timpe, Clara Marie Fides; Slapø, Nora Berz & Melle, Ingrid [Vis alle 14 forfattere av denne artikkelen] (2024). Mismatch negativity and polygenic risk scores for schizophrenia and bipolar disorder. Schizophrenia Research. ISSN 0920-9964. 264, s. 314–326. doi: 10.1016/j.schres.2024.01.013.
• Pentz, Atle Bråthen; Timpe, Clara Marie Fides; Normann, Elizabeth Marie; Slapø, Nora Berz; Melle, Ingrid & Lagerberg, Trine Vik [Vis alle 13 forfattere av denne artikkelen] (2023). Mismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity. Schizophrenia Research. ISSN 0920-9964. 261, s. 80–93. doi: 10.1016/j.schres.2023.09.012. Fulltekst i vitenarkiv
• Slapø, Nora Berz; Nerland, Stener; Jørgensen, Kjetil Nordbø; Mørch-Johnsen, Lynn Egeland; Pettersen, Johanne Hagen & Roelfs, Daniel [Vis alle 22 forfattere av denne artikkelen] (2023). Auditory Cortex Thickness Is Associated With N100 Amplitude in Schizophrenia Spectrum Disorders. Schizophrenia Bulletin Open. ISSN 2632-7899. 4(1). doi: 10.1093/schizbullopen/sgad015. Fulltekst i vitenarkiv
• Schijven, Dick; Postema, Merel C.; Fukunaga, Masaki; Matsumoto, Junya; Miura, Kenichiro & de Zwarte, Sonja M.C. [Vis alle 149 forfattere av denne artikkelen] (2023). Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 120(14). doi: 10.1073/pnas.2213880120. Fulltekst i vitenarkiv
• Slapø, Nora Berz; Jørgensen, Kjetil Nordbø; Elvsåshagen, Torbjørn; Nerland, Stener; Roelfs, Daniel & Valstad, Mathias [Vis alle 18 forfattere av denne artikkelen] (2023). Relationship between function and structure in the visual cortex in healthy individuals and in patients with severe mental disorders. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 332. doi: 10.1016/j.pscychresns.2023.111633. Fulltekst i vitenarkiv Vis sammendrag

  Patients with schizophrenia spectrum disorders (SCZspect) and bipolar disorders (BD) show impaired function in the primary visual cortex (V1), indicated by altered visual evoked potential (VEP). While the neural substrate for altered VEP in these patients remains elusive, altered V1 structure may play a role. One previous study found a positive relationship between the amplitude of the P100 component of the VEP and V1 surface area, but not V1 thickness, in a small sample of healthy individuals. Here, we aimed to replicate these findings in a larger healthy control (HC) sample (n = 307) and to examine the same relationship in patients with SCZspect (n = 30) or BD (n = 45). We also compared the mean P100 amplitude, V1 surface area and V1 thickness between controls and patients and found no significant group differences. In HC only, we found a significant positive P100-V1 surface area association, while there were no significant P100-V1 thickness relationships in HC, SCZspect or BD. Together, our results confirm previous findings of a positive P100-V1 surface area association in HC, whereas larger patient samples are needed to further clarify the function-structure relationship in V1 in SCZspect and BD.

• Barth, Claudia; Kelly, Sinead; Nerland, Stener; Jahanshad, Neda; Alloza, Clara & Ambrogi, Sonia [Vis alle 44 forfattere av denne artikkelen] (2022). In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis. Molecular Psychiatry. ISSN 1359-4184. s. 1–11. doi: 10.1038/s41380-022-01901-3. Fulltekst i vitenarkiv Vis sammendrag

  Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen’s d = 0.37), posterior corona radiata (d = 0.32), and superior fronto‐occipital fasciculus (d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.

• Rootes-Murdy, Kelly; Edmond, Jesse T.; Jiang, Wenhao; Rahaman, Md A.; Chen, Jiayu & Perrone-Bizzozero, Nora I. [Vis alle 24 forfattere av denne artikkelen] (2022). Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach. Frontiers in Human Neuroscience. ISSN 1662-5161. 16. doi: 10.3389/fnhum.2022.1001692. Fulltekst i vitenarkiv
• Brouwer, Rachel M.; Klein, Marieke; Grasby, Katrina L.; Schnack, Hugo G.; Jahanshad, Neda & Teeuw, Jalmar [Vis alle 200 forfattere av denne artikkelen] (2022). Genetic variants associated with longitudinal changes in brain structure across the lifespan. Nature Neuroscience. ISSN 1097-6256. 25(4), s. 421–432. doi: 10.1038/s41593-022-01042-4.
• Frangou, Sophia; Modabbernia, Amirhossein; Williams, Steven C. R.; Papachristou, Efstathios; Doucet, Gaëlle E. & Agartz, Ingrid [Vis alle 63 forfattere av denne artikkelen] (2022). Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Human Brain Mapping. ISSN 1065-9471. 43(1), s. 431–451. doi: 10.1002/hbm.25364. Fulltekst i vitenarkiv
• Dima, Danai; Modabbernia, Amirhossein; Papachristou, Efstathios; Doucet, Gaëlle E.; Agartz, Ingrid & Aghajani, Moji [Vis alle 52 forfattere av denne artikkelen] (2022). Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping. ISSN 1065-9471. 43(1), s. 452–469. doi: 10.1002/hbm.25320. Fulltekst i vitenarkiv
• Blokland, Gabriella A. M.; Grove, Jakob; Chen, Chia-Yen; Cotsapas, Chris; Tobet, Stuart & Handa, Robert [Vis alle 50 forfattere av denne artikkelen] (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry. ISSN 0006-3223. 91, s. 102–117. doi: 10.1016/j.biopsych.2021.02.972. Fulltekst i vitenarkiv Vis sammendrag

  Background Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.

• Smit, Dirk J. A.; Andreassen, Ole; Boomsma, Dorret I.; Burwell, Scott J.; Chorlian, David B. & De Geus, Eco J C [Vis alle 28 forfattere av denne artikkelen] (2021). Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. Brain and Behavior. ISSN 2162-3279. 11(8). doi: 10.1002/brb3.2188. Fulltekst i vitenarkiv
• Hilland, Eva; Johannessen, Cecilie Haggag; Jonassen, Rune; Alnæs, Dag; Jørgensen, Kjetil Nordbø & Barth, Claudia [Vis alle 17 forfattere av denne artikkelen] (2021). Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study. NeuroImage: Clinical. ISSN 2213-1582. 33. doi: 10.1016/j.nicl.2021.102881. Fulltekst i vitenarkiv
• Valstad, Mathias; Roelfs, Daniel; Slapø, Nora Berz; Timpe, Clara Marie Fides; Rai, Ahsan & Matziorinis, Anna Maria [Vis alle 24 forfattere av denne artikkelen] (2021). Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin. ISSN 0586-7614. 47(6), s. 1751–1760. doi: 10.1093/schbul/sbab049. Fulltekst i vitenarkiv
• Jiang, Wenhao; Rootes-Murdy, Kelly; Chen, Jiayu; Bizzozero, Nora I.Perrone-; Calhoun, Vince D. & van Erp, Theo G.M. [Vis alle 16 forfattere av denne artikkelen] (2021). Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia. Psychiatry Research. ISSN 0165-1781. 306. doi: 10.1016/j.psychres.2021.114237.
• Fagerberg, Tomas; Söderman, Erik; Gustavsson, Petter; Agartz, Ingrid; Jönsson, Erik G. & Jönsson, Erik Gunnar (2021). Thirteen-year follow-up of long-term treated psychotic disorder: personality aspects. Nordic Journal of Psychiatry. ISSN 0803-9488. s. 1–9. doi: 10.1080/08039488.2021.1981436. Fulltekst i vitenarkiv
• Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi & Ellegaard, Maria [Vis alle 76 forfattere av denne artikkelen] (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01213-0. Fulltekst i vitenarkiv
• Chen, Jiayu; Li, Xiang; Calhoun, Vince D.; Turner, Jessica A.; van Erp, Theo G.M. & Wang, Lei [Vis alle 16 forfattere av denne artikkelen] (2021). Sparse deep neural networks on imaging genetics for schizophrenia case–control classification. Human Brain Mapping. ISSN 1065-9471. 42(8), s. 2556–2568. doi: 10.1002/hbm.25387. Fulltekst i vitenarkiv
• Fagerberg, Tomas; Söderman, Erik; Gustavsson, J. Petter; Agartz, Ingrid & Jönsson, Erik Gunnar (2021). Swedish universities scales of personality: Relation to other personality instruments. Psychiatry Investigation. ISSN 1738-3684. 18(5), s. 373–384. doi: 10.30773/pi.2020.0052. Fulltekst i vitenarkiv
• Sæther, Linn Sofie; Roelfs, Daniël Thomas Heimen; Moberget, Torgeir; Andreassen, Ole Andreas; Elvsåshagen, Torbjørn & Jönsson, Erik Gunnar [Vis alle 7 forfattere av denne artikkelen] (2020). Exploring neurophysiological markers of visual perspective taking: Methodological considerations. International Journal of Psychophysiology. ISSN 0167-8760. doi: 10.1016/j.ijpsycho.2020.12.006. Fulltekst i vitenarkiv Vis sammendrag

  Rationale: For visual perspective taking (VPT) using the avatar task, examinations of neural processes using event related potentials (ERP) indicate a distinction between an early posterior perspective calculation process (P3) and a later frontal process (LFSW) managing perspective conflict. While it is unknown if these neural processes are affected in clinical populations, it is unclear if the avatar task can be applied to this group, due to the long duration and sensitivity to data loss. Thus, we performed a methodological study of the avatar task, testing the feasibility of a shortened experimental paradigm. Objective: To investigate whether previously reported behavioural and ERP effects in the avatar task can also be seen if analysing all trials (matching/non-matching) jointly, and whether they remain robust if only a subset of the data is analysed. Method: Healthy individuals (n = 20) completed the avatar task with ERP measurement. ERP components (P3, LFSW) and behavioural data were investigated by A) comparing use of only matching trials (n = 384) versus all trials (n = 768), and B) examining if reduced duration of assessment, by analysing only a subset of the data, impacts ERP findings. Results: We observed minimal differences when analysing data from only matching trial types compared to all trial types. Further, ERP amplitudes and latency findings were replicated when analysing only a subset of the data. Conclusions: The duration of the avatar task can be reduced to avoid long testing times, thus making it better suited for use in clinical populations.

• Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides & Beck, Dani [Vis alle 18 forfattere av denne artikkelen] (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage. ISSN 1053-8119. doi: 10.1016/j.neuroimage.2020.117302. Fulltekst i vitenarkiv
• Wierenga, Lara M.; Doucet, Gaëlle E.; Dima, Danai; Agartz, Ingrid; Aghajani, Moji & Akudjedu, Theophilus N. [Vis alle 50 forfattere av denne artikkelen] (2020). Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping. ISSN 1065-9471. 43, s. 470–499. doi: 10.1002/hbm.25204. Fulltekst i vitenarkiv
• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita & Hibar, DP [Vis alle 50 forfattere av denne artikkelen] (2020). The genetic architecture of the human cerebral cortex. Science. ISSN 0036-8075. 367(6484). doi: 10.1126/science.aay6690. Fulltekst i vitenarkiv Vis sammendrag

  INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.

• de Zwarte, Sonja M. C.; Brouwer, Rachel M; Agartz, Ingrid; Alda, Martin; Alonso-Lana, Silvia & Bearden, Carrie E [Vis alle 50 forfattere av denne artikkelen] (2020). Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25206. Fulltekst i vitenarkiv
• Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag & Barch, Deanna M. [Vis alle 76 forfattere av denne artikkelen] (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17376-1. Fulltekst i vitenarkiv Vis sammendrag

  Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

• Benjamin, Silje Beatrice Rognås; Valstad, Mathias; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Moberget, Torgeir & Winterton, Adriano [Vis alle 14 forfattere av denne artikkelen] (2020). Heart rate variability is associated with disease severity in psychosis spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 00:110108, s. 1–8. doi: 10.1016/j.pnpbp.2020.110108. Fulltekst i vitenarkiv
• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng & Alnæs, Dag [Vis alle 40 forfattere av denne artikkelen] (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. s. 1–8. doi: 10.1038/s41380-020-0664-1. Fulltekst i vitenarkiv
• Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Doan, Nhat Trung & Alnæs, Dag [Vis alle 33 forfattere av denne artikkelen] (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 5(12), s. 1095–1103. doi: 10.1016/j.bpsc.2020.06.014. Fulltekst i vitenarkiv
• Barth, Claudia; Jørgensen, Kjetil Nordbø; Wortinger, Laura Anne ; Nerland, Stener; Jönsson, Erik Gunnar & Agartz, Ingrid (2020). Trajectories of brain volume change over 13 years in chronic schizophrenia. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2020.05.014.
• Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Lonning, Vera; Jönsson, Erik Gunnar; Pasternak, Ofer & Agartz, Ingrid (2020). Microstructural white matter and links with subcortical structures in chronic schizophrenia: A free-water imaging approach. Frontiers in Psychiatry. ISSN 1664-0640. 11. doi: 10.3389/fpsyt.2020.00056. Fulltekst i vitenarkiv
• Andreou, Dimitrios; Saetre, Peter; Milesson Fors, Björn; Nilsson, Björn Mikael; Kullberg, Joel & Jönsson, Erik Gunnar [Vis alle 8 forfattere av denne artikkelen] (2020). Cardiac left ventricular ejection fraction in men and women with schizophrenia on long-term antipsychotic treatment. Schizophrenia Research. ISSN 0920-9964. s. 226–232. doi: 10.1016/j.schres.2019.12.042. Fulltekst i vitenarkiv
• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob & Zhu, Zhaozhong [Vis alle 66 forfattere av denne artikkelen] (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. ISSN 0092-8674. 179(7), s. 1469–1482. doi: 10.1016/j.cell.2019.11.020. Fulltekst i vitenarkiv
• Hess, JL; Tylee, JS; Mattheisen, M; Agartz, Ingrid; Andreassen, Ole Andreas & Djurovic, Srdjan [Vis alle 11 forfattere av denne artikkelen] (2019). A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-019-0463-8.
• Richards, Alexander L.; Pardiñas, Antonio F.; Frizzati, Aura; Tansey, Katherine E.; Lynham, Amy J. & Holmans, Peter [Vis alle 48 forfattere av denne artikkelen] (2019). The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. Schizophrenia Bulletin. ISSN 0586-7614. doi: 10.1093/schbul/sbz061. Vis sammendrag

  BACKGROUND: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. METHODS: We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results were then meta-analyzed across all samples. A genome-wide association studies (GWAS) of cognition was conducted in schizophrenia cases. RESULTS: PRS for both population IQ (P = 4.39 x 10-28) and EA (P = 1.27 x 10-26) were positively correlated with cognition in those with schizophrenia. In contrast, there was no association between cognition in schizophrenia cases and PRS for schizophrenia (P = .39), BD (P = .51), or MDD (P = .49). No individual variant approached genome-wide significance in the GWAS. CONCLUSIONS: Cognition in schizophrenia cases is more strongly associated with PRS that index cognitive traits in the general population than PRS for neuropsychiatric disorders. This suggests the mechanisms of cognitive variation within schizophrenia are at least partly independent from those that predispose to schizophrenia diagnosis itself. Our findings indicate that this cognitive variation arises at least in part due to genetic factors shared with cognitive performance in populations and is not solely due to illness or treatment-related factors, although our findings are consistent with important contributions from these factors.

• de Zwarte, Sonja M.C.; Brouwer, Rachel M.; Agartz, Ingrid; Alda, Martin; Aleman, André & Alpert, Kathryn I. [Vis alle 91 forfattere av denne artikkelen] (2019). The association between familial risk and brain abnormalities is disease specific: An ENIGMA-relatives study of schizophrenia and bipolar disorder. Biological Psychiatry. ISSN 0006-3223. 86(7), s. 545–556. doi: 10.1016/j.biopsych.2019.03.985. Fulltekst i vitenarkiv
• Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav & Moberget, Torgeir [Vis alle 30 forfattere av denne artikkelen] (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry. ISSN 2168-6238. 76(7), s. 739–748. doi: 10.1001/jamapsychiatry.2019.0257.
• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen & Matson, Wayne [Vis alle 13 forfattere av denne artikkelen] (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine. ISSN 0033-2917. 17(2). doi: 10.1017/S0033291719000400. Fulltekst i vitenarkiv
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, s. 87–95. doi: 10.1016/j.psyneuen.2019.01.001. Fulltekst i vitenarkiv
• Clapham, Eric; Boden, Robert; Brandt, Lena; Jönsson, Erik Gunnar; Bahmanyar, Shahram & Ekbom, Anders [Vis alle 8 forfattere av denne artikkelen] (2018). Suicide Ideation and Behavior as Risk Factors for Subsequent Suicide in Schizophrenia: A Nested Case?Control Study. Suicide and Life-Threatening Behaviour. ISSN 0363-0234. doi: 10.1111/sltb.12499.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, s. 74–81. doi: 10.1016/j.jpsychires.2018.09.014.
• van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir & Alnæs, Dag [Vis alle 54 forfattere av denne artikkelen] (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. s. 1–13. doi: 10.1038/s41380-018-0262-7. Fulltekst i vitenarkiv
• Ni, Guiyan; Gratten, Jacob; Wray, Naomi R.; Lee, Sang Hong; Agartz, Ingrid & Djurovic, Srdjan [Vis alle 11 forfattere av denne artikkelen] (2018). Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-28160-z. Fulltekst i vitenarkiv
• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao & Glahn, David C. [Vis alle 151 forfattere av denne artikkelen] (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2018.04.023. Fulltekst i vitenarkiv
• Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas & Bøen, Erlend [Vis alle 33 forfattere av denne artikkelen] (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(22), s. E5154–E5163. doi: 10.1073/pnas.1718418115.
• Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt & Schork, Andrew J. [Vis alle 18 forfattere av denne artikkelen] (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports. ISSN 2045-2322. 674(8), s. 1–8. doi: 10.1038/s41598-017-16481-4. Fulltekst i vitenarkiv
• Hjärpe, Josefin; Söderman, Erik; Andreou, Dimitrios; Sedvall, Göran C.; Agartz, Ingrid & Jönsson, Erik Gunnar (2018). No major influence of regular tobacco smoking on cerebrospinal fluid monoamine metabolite concentrations in patients with psychotic disorder and healthy individuals. Psychiatry Research. ISSN 0165-1781. 263, s. 30–34. doi: 10.1016/j.psychres.2018.02.036.
• Fagerberg, Tomas; Söderman, Erik; Gustavsson, J. Petter; Agartz, Ingrid & Jönsson, Erik Gunnar (2018). Stability of personality traits over a five-year period in Swedish patients with schizophrenia spectrum disorder and non-psychotic individuals: a study using the Swedish universities Scales of Personality. BMC Psychiatry. ISSN 1471-244X. 18(54). doi: 10.1186/s12888-018-1617-y. Fulltekst i vitenarkiv
• Walton, E; Hibar, Derrek; Van Erp, Theo G M; Potkin, Steven G; Roiz-Santiañez, Roberto & Crespo-Facorro, B [Vis alle 58 forfattere av denne artikkelen] (2018). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine. ISSN 0033-2917. 48(1), s. 82–94. doi: 10.1017/S0033291717001283. Fulltekst i vitenarkiv
• Jokinen, Jussi; Königsson, Johan; Moberg, Tomas; Jönsson, Erik Gunnar; Tiihonen, Jari & Nordström, Peter [Vis alle 8 forfattere av denne artikkelen] (2018). Platelet monoamine oxidase activity and interpersonal violence in male suicide attempters. Psychiatry Research. ISSN 0165-1781. 260, s. 173|–176. doi: 10.1016/j.psychres.2017.11.057. Fulltekst i vitenarkiv Vis sammendrag

  Low platelet monoamine oxidase B (MAO-B) activity, proxy of low central serotonergic functions, has been shown to correlate with criminal behavior in adolescents that come from an unfavorable psychosocial environment but not in adolescents from good conditions, indicating a link between environment, MAO-B activity and aggressive behavior. The purpose of this study was to examine the association between MAO-B activity and lifetime interpersonal violence in suicide attempters. The study included a total of 28 suicide attempters (18 men and 10 women). Assessments of childhood exposure to and expressed interpersonal violence during childhood and as an adult were carried out with the Karolinska Interpersonal Violence Scale (KIVS). Platelet MAO-B activity was measured with 2-phenylethylamine (b-PEA) as substrate. Broken down by gender, the correlations between platelet MAO-B activity and both exposure scores to interpersonal violence as a child and expressed lifetime interpersonal violence were significant in male suicide attempters (r = -0.61, p = 0.035; r = -0.84, p = 0.0005), but not in women. Our finding of significant associations between interpersonal violence and low MAO-B activity need to be replicated in other cohorts of suicide attempters.

• Kelly, S; Jahanshad, Neda; Zalesky, A; P, Kochunov; Agartz, Ingrid & Alloza, C [Vis alle 158 forfattere av denne artikkelen] (2018). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, s. 1261–1269. doi: 10.1038/mp.2017.170. Fulltekst i vitenarkiv
• Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene & Gardsjord, Erlend Strand [Vis alle 11 forfattere av denne artikkelen] (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 82, s. 263–271. doi: 10.1016/j.pnpbp.2017.11.004.
• Moberget, Torgeir; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo & Lagerberg, Trine Vik [Vis alle 22 forfattere av denne artikkelen] (2017). Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls. Molecular Psychiatry. ISSN 1359-4184. 23(6), s. 1512–1520. doi: 10.1038/mp.2017.106.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Kauppi, Karolina; Hill, W. David; Li, Wen & Wang, Yunpeng [Vis alle 22 forfattere av denne artikkelen] (2017). Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA psychiatry. ISSN 2168-6238. 74(10), s. 1065–1075. doi: 10.1001/jamapsychiatry.2017.1986. Fulltekst i vitenarkiv
• Comasco, Erika; Vumma, Ravi; Toffoletto, Simone; Johansson, Jessica; Flyckt, Lena & Lewander, Tommy [Vis alle 14 forfattere av denne artikkelen] (2017). Genetic and functional study of L -Type amino acid transporter 1 in schizophrenia. Neuropsychobiology. ISSN 0302-282X. 74(2), s. 96–103. doi: 10.1159/000455234.
• Walton, Esther Fintan; Hibar, Derrek; Van Erp, Theo G.M.; Potkin, Steven G.; Roiz-Santiáñez, Roberto & Crespo-Facorro, Benedicto [Vis alle 59 forfattere av denne artikkelen] (2017). Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 135(5), s. 439–447. doi: 10.1111/acps.12718.
• Nesvåg, Ragnar; Jönsson, Erik Gunnar; Bakken, Inger Johanne; Knudsen, Gun Peggy; Bjella, Thomas & Reichborn-Kjennerud, Ted [Vis alle 8 forfattere av denne artikkelen] (2017). The quality of severe mental disorder diagnoses in a national health registry as compared to research diagnoses based on structured interview. BMC Psychiatry. ISSN 1471-244X. 17(1). doi: 10.1186/s12888-017-1256-8. Fulltekst i vitenarkiv
• Fagerberg, Tomas; Söderman, Erik; Gustavsson, Petter; Agartz, Ingrid & Jönsson, Erik Gunnar (2016). Personality traits in established schizophrenia: aspects of usability and differences between patients and controls using the Swedish universities Scales of Personality. Nordic Journal of Psychiatry. ISSN 0803-9488. 70(6), s. 462–469. doi: 10.3109/08039488.2016.1159331.
• Skåtun, Kristina Cecilie; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo & Jönsson, Erik Gunnar [Vis alle 12 forfattere av denne artikkelen] (2016). Consistent functional connectivity alterations in schizophrenia spectrum disorder: a multisite study. Schizophrenia Bulletin. ISSN 0586-7614. 43(4), s. 914–924. doi: 10.1093/schbul/sbw145.
• Reutfors, Johan; Clapham, Eric; Bahmanyar, Shahram; Brandt, Lena; Jönsson, Erik Gunnar & Ekbom, Anders [Vis alle 8 forfattere av denne artikkelen] (2016). Suicide risk and antipsychotic side effects in schizophrenia: nested case–control study. Human Psychopharmacology: Clinical and Experimental. ISSN 0885-6222. s. 341–345. doi: 10.1002/hup.2536.
• Guadalupe, Tulio; Mathias, Samuel R.; VanErp, Theo G.M.; Whelan, Christopher D.; Zwiers, Marcel P. & Abe, Yoshinari [Vis alle 161 forfattere av denne artikkelen] (2016). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior. ISSN 1931-7557. Published ahead of print, s. 1–18. doi: 10.1007/s11682-016-9629-z.
• Borg, Jacqueline; Cervenka, Simon; Kuja-Halkola, Ralf; Matheson, Granville; Jönsson, Erik Gunnar & Lichtenstein, Paul [Vis alle 12 forfattere av denne artikkelen] (2016). Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain. Molecular Psychiatry. ISSN 1359-4184. 21(8), s. 1077–1084. doi: 10.1038/mp.2015.147.
• Ladenberger, Anna; Demetriades, Alecos; Reimann, Clemens; Birke, Manfred; Sadeghi, Martiya & Uhlbäck, Jo [Vis alle 84 forfattere av denne artikkelen] (2015). GEMAS: Indium in agricultural and grazing land soil of Europe - Its source and geochemical distribution patterns. Journal of Geochemical Exploration. ISSN 0375-6742. 154, s. 61–80. doi: 10.1016/j.gexplo.2014.11.020.
• Moberg, Tomas; Stenbacka, Marlene; Tengström, Anders; Jönsson, Erik Gunnar; Nordström, Peter & Jokinen, Jussi (2015). Psychiatric and neurological disorders in late adolescence and risk of convictions for violent crime in men. BMC Psychiatry. ISSN 1471-244X. 15:299, s. 1–9. doi: 10.1186/s12888-015-0683-7.
• Jørgensen, Kjetil Nordbø; Nesvåg, Ragnar; Gunleiksrud, Sindre; Raballo, Andrea; Jönsson, Erik Gunnar & Agartz, Ingrid (2015). First- and second-generation antipsychotic drug treatment and subcortical brain morphology in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-015-0650-9.
• Andreou, Dimitrios; Söderman, Erik; Axelsson, Tomas; Sedvall, Göran C.; Terenius, Lars & Agartz, Ingrid [Vis alle 7 forfattere av denne artikkelen] (2015). Cerebrospinal fluid monoamine metabolite concentrations as intermediate phenotypes between glutamate-related genes and psychosis. Psychiatry Research. ISSN 0165-1781. 229(1-2), s. 497–504. doi: 10.1016/j.psychres.2015.06.023.
• Fazio, Patrik; Svenningsson, Per; Forsberg, Anton; Jönsson, Erik Gunnar; Amini, Nahid & Nakao, Ryuji [Vis alle 10 forfattere av denne artikkelen] (2015). Quantitative analysis of &amp;lt;sup&amp;gt;18&amp;lt;/sup&amp;gt;F-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4'-methyl-phenyl) nortropane binding to the dopamine transporter in Parkinson disease. Journal of Nuclear Medicine. ISSN 0161-5505. 56(5), s. 714–720. doi: 10.2967/jnumed.114.152421.
• van Erp, Theo GM; Hibar, Derrek; Rasmussen, JM; Glahn, David C; Pearlson, Godfrey D & Andreassen, Ole Andreas [Vis alle 58 forfattere av denne artikkelen] (2015). Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry. ISSN 1359-4184. 21(4), s. 547–553. doi: 10.1038/mp.2015.63. Vis sammendrag

  The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen’s d = − 0.46), amygdala (d = − 0.31), thalamus (d = − 0.31), accumbens (d = − 0.25) and intracranial volumes (d = − 0.12), as well as larger pallidum (d = 0.21) and lateral ventricle volumes (d = 0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness.

• Andreou, Dimitrios; Söderman, Erik; Axelsson, Tomas; Sedvall, Göran C.; Terenius, Lars & Agartz, Ingrid [Vis alle 7 forfattere av denne artikkelen] (2014). Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis. Behavioral and Brain Functions. ISSN 1744-9081. 10(26). doi: 10.1186/1744-9081-10-26.
• Moberg, Tomas; Stenbacka, Marlene; Jönsson, Erik Gunnar; Nordström, Peter; Åsberg, Marie & Jokinen, Jussi (2014). Risk factors for adult interpersonal violence in suicide attempters. BMC Psychiatry. ISSN 1471-244X. 14(1). doi: 10.1186/1471-244X-14-195.

Se alle arbeider i Cristin

• Jørgensen, Kjetil Nordbø; Nerland, Stener; Moberget, Torgeir; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2019). Optimizing the T1/T2 ratio for analysis within and between subjects.
• Fagerberg, Tomas; Söderman, Erik; Gustavsson, J. Petter; Agartz, Ingrid & Jönsson, Erik Gunnar (2019). Correction to: Stability of personality traits over a five-year period in Swedish patients with schizophrenia spectrum disorder and nonpsychotic individuals: A study using the Swedish universities scales of personality. BMC Psychiatry. ISSN 1471-244X. 19(109). doi: 10.1186/s12888-019-2086-7.
• Santillo, Alexander F; Lundgren, Sofia; Xu, C; Orhan, Funda; Fatouros-Bergman, Helena & Blennow, Kaj [Vis alle 12 forfattere av denne artikkelen] (2019). Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis. Schizophrenia Research. ISSN 0920-9964. 208, s. 490–492. doi: 10.1016/j.schres.2019.01.010. Fulltekst i vitenarkiv
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Vis alle 11 forfattere av denne artikkelen] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.

Se alle arbeider i Cristin