Hanne Christine Mohn

• Mohn, Christine (2026). Kronisk smerte og selvmordsatferd – overlappende fysiologiske prosesser som forklaring. Suicidologi. ISSN 1501-6994. 31(2), s. 12–17. doi: 10.5617/suicidologi.13636. Fulltekst i vitenarkiv Vis sammendrag

  Kroniske smertetilstander er forbundet med økt risiko for selvmordsatferd. Begge disse tilstandene kjennetegnes også av symptomer på psykiske lidelser, spesielt depresjon, sosial isolasjon og ensomhet, og disse faktorene kan forsterke hverandre gjensidig. Kronisk smerte, depresjonslidelser og ensomhet kjennetegnes dessuten av delvis overlappende nevrofysiologisk aktivitet i de samme hjerneområdene – det limbiske system og ventromediale prefrontal cortex. Videre kan det fysisk smertefulle i tiden før et selvmord korrespondere med det klassiske suicidologiske begrepet psychache. Det overlappende nevrobiologiske grunnlaget for fenomenene fysisk smerte, psykiske plager og sosial utstøtelse kan forklares evolusjonistisk, og hvis disse tilstandene vedvarer, kan selvmord oppleves som en måte å unnslippe det sammensatte lidelsesbildet.

• Mohn, Christine; Haga, Egil; Nilsson, Hanne Sofie Wernø & Mehlum, Lars (2026). Who notices suicide prevention media campaigns? Demographic characteristics and attitudes to suicide and help-seeking. Psychiatry Research Communications. 6(4). doi: 10.1016/j.psycom.2026.100285. Fulltekst i vitenarkiv Vis sammendrag

  Public media campaigns have the potential to reach large numbers of people with suicide prevention messages. However, relatively few individuals among the exposed population report being aware of the campaigns when they occur. Those who notice these campaigns may differ from those who do not in key variables relevant for suicide prevention interventions. In this study, we compare the demographic characteristics and attitudes to suicide and help-seeking in these two groups. In 2022 and 2023, three regional uniform suicide prevention media campaigns were carried out in Mid-, West- and South-Norway. Before and after each campaign, sex- and age-representative samples of the population completed surveys of demographic variables and attitudes to suicide and help-seeking. Among the 3234 participants, n = 644 (20%) reported having noticed the campaign, and n = 2590 (80%) did not. In the campaign awareness group, there were significantly fewer members in the 30-39 age bracket and more members in the 70-79 age bracket than among the non-aware group. Moreover, the campaign awareness group had a higher proportion of people with MA level education, in retirement, and who had family members or friends who had died by suicide or attempted suicide. In this group, there was also slightly higher preparedness to help a suicidal person. The effect sizes were small. Logistic regression analyses revealed not belonging to the 30-39 age bracket and having family/friends with suicidal behaviour as significant predictors of campaign awareness.

• Mohn, Christine; Haga, Egil; Nilsson, Hanne Sofie Wenø & Mehlum, Lars (2026). Changes in Attitudes After Suicide Prevention Media Campaigns in Three Norwegian Regions. Archives of Suicide Research. ISSN 1381-1118. doi: 10.1080/13811118.2026.2624605. Fulltekst i vitenarkiv
• Calkova, Tereza; Vaskinn, Anja; Mørch-Johnsen, Lynn Egeland; Smelror, Runar; Jørgensen, Kjetil Nordbø & Wortinger, Laura Anne [Vis alle 18 forfattere av denne artikkelen] (2025). Early versus adult onset of schizophrenia: an examination of premorbid and current IQ. Schizophrenia Research: Cognition. 43, s. 100397–100397. doi: 10.1016/j.scog.2025.100397. Fulltekst i vitenarkiv Vis sammendrag

  Background Cognitive deficits are core findings in schizophrenia, but whether the severity of impairments is related to the age of onset remains unclear. We hypothesized that early onset schizophrenia (EOS; onset before age 19) is associated with lower IQ compared to adult-onset schizophrenia (AOS; onset from age 19). Methods We included 99 adult patients with EOS (age of onset: 15.3 ± 2.8 years), 282 adult patients with AOS (age of onset: 26.5 ± 7.4 years), and 863 adult healthy controls (HC). We assessed current IQ with Wechsler Abbreviated Scale of Intelligence (WASI) and estimated premorbid IQ with National Adult Reading Test (NART). Results Both patient groups had lower current IQ than HC ( p < 0.001). Full-scale ( p = 0.004), performance ( p = 0.003) and verbal ( p = 0.011) current IQ were significantly lower in EOS than in AOS, with 5 IQ units difference for all three measures. EOS and AOS did not differ in premorbid IQ, but EOS showed a steeper IQ decline from premorbid levels than AOS (11.4 vs. 8 IQ units, respectively, p = 0.013). Conclusion EOS had lower current IQ than AOS, but did not differ in premorbid IQ, suggesting a larger decline from premorbid IQ levels. This could imply different neurodevelopmental processes underlying cognitive dysfunction related to age of onset in schizophrenia, underscoring the necessity for further inquiry into the mechanisms driving this decline and strategies for its prevention.

• Mohn, Christine; Olsson, Anna-Karin; Olsson-Tall, Maivor; Hjärthag, Fredrik; Härd, Iris van Dijk & Helldin, Lars (2025). Neurocognitive function in schizophrenia spectrum disorders: A 20-year prospective study of a community sample. Schizophrenia Research: Cognition. 43. doi: 10.1016/j.scog.2025.100393. Fulltekst i vitenarkiv
• Grimstad, Kristoffer; Sørensen, Håkon; Vaskinn, Anja; Mohn, Hanne Christine; Glastad, Stine Holmstul & Andreassen, Ole [Vis alle 11 forfattere av denne artikkelen] (2025). Subjective cognition in schizophrenia and bipolar disorder: Investigation of group differences and associations with objective cognition and clinical characteristics using a novel measure of subjective cognition. Schizophrenia Research: Cognition. 40. doi: 10.1016/j.scog.2025.100345. Fulltekst i vitenarkiv
• Torgalsbøen, Anne-Kari; Mohn, Christine; Larøi, Frank & Czajkowski, Nikolai Olavi (2025). Longitudinal recovery and self-efficacy in first-episode schizophrenia: insights from a 10-year follow-up study. Frontiers in Psychiatry. s. 01–09. doi: 10.3389/fpsyt2025.1588349. Fulltekst i vitenarkiv Vis sammendrag

  Background: Research on clinical recovery rates in first-episode schizophrenia has yielded inconsistent results due to varying definitions of recovery and methodological differences. The longitudinal trajectory of recovery—whether rates improve, decline, or remain stable—remains unclear. Schizophrenia significantly impacts young lives, making it crucial to examine self-efficacy, the belief in one’s ability to manage adversity, and its relationship with clinical recovery. Methods: The Oslo Schizophrenia Recovery study`s repeated assessment design, including twelve clinical evaluations over ten years, is ideal for studying longitudinal recovery. Self-efficacy was measured using the General Perceived Self-Efficacy scale, with data analyzed through linear multilevel models. Twenty-eight well-defined first-episode schizophrenia patients were assessed yearly, using a strict recovery definition (two years of full symptom remission and adequate social/role functioning), with 79% of patients retained from baseline. Results: Recovery rates improved and remained stable, suggesting better outcomes than previously reported. Of the participants, 50% achieved clinical recovery. Recovered individuals showed a sharp increase in self-efficacy within the first year, while non-recovered patients exhibited gradual improvement. The interaction between recovery status and time revealed distinct self-efficacy trajectories, particularly in the first post-onset year. Conclusions: A significant proportion of first-episode schizophrenia patients can achieve clinical recovery. While these positive outcomes are noteworthy, it is important to recognize that recovery paths can vary widely among individuals. Since people with schizophrenia are concerned about their chances of recovery, the results must be shared with patients and their families. While the causal relationship between self-efficacy and recovery remains unclear, they likely influence each other.

• Mohn, Hanne Christine; Haga, Egil; Nilsson, Hanne Sofie Wernø; Pirkis, Jane & Mehlum, Lars (2025). Predictors of not wanting to seek help or information for suicide thoughts. BMC Psychiatry. 25. doi: 10.1186/s12888-025-06985-z. Fulltekst i vitenarkiv Vis sammendrag

  Background Approximately half of all individuals who die by suicide in Norway do not seek contact with specialist mental health services during the year before death. Here we aim to report the demographic characteristics and attitudes to suicide, mental ill health, and help-seeking in people who do not wish to seek help or information for suicide thoughts. Moreover, we identify the strongest predictors of non-help-seeking intentions. Methods A population sample (N = 3251) from the Mid- and West- Norway regions participated in an online survey of attitudes to suicide and help-seeking for mental ill health. The sample was recruited from the regional population that later was exposed to a media suicide prevention campaign. Of these, 167 individuals stated that they would not seek help or information if they were to get suicide thoughts. Results The group of people who would not seek help or information for suicide thoughts, were more likely to be male, aged between 40 and 49 years, not being retired, or having experienced suicide or suicide attempts among family or friends, compared to the group that stated their help-seeking intentions. Moreover, they were more likely to report more negative attitudes to suicide (e.g., believing it can’t be prevented, or that it should not be talked about), mental illness (e.g., wanting to hide depression, or wanting to sort out problems on their own), and help-seeking (e.g., feeling inferior if seeking professional help, or not being confident in getting help) as well as lower levels of support from family or friends. Stepwise logistic regression analyses identified male sex, not being confident in getting professional help for suicide thoughts, not being able to talk to family or friends about problems, and not wanting to disclose having depression, as the statistically significant predictors of not wanting to seek help or information, explaining 28% of the variance. Conclusions We conclude that these factors should be targeted in future suicide prevention efforts in Norway. In particular, the strongest predictor (Not being confident in getting professional care for suicide thoughts), should be addressed.

• Torgalsbøen, Anne-Kari; Mohn, Hanne Christine; Larøi, Frank & Czajkowski, Nikolai Olavi (2025). Longitudinal recovery and self-efficacy in first-episode schizophrenia: insights from a 10-year follow-up study. Frontiers in Psychiatry. 16. doi: 10.3389/fpsyt.2025.1588349. Fulltekst i vitenarkiv
• Sæther, Linn Sofie; Szabo, Attila; Akkouh, Ibrahim Ahmed; Haatveit, Beathe; Mohn, Christine & Vaskinn, Anja [Vis alle 14 forfattere av denne artikkelen] (2024). Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain. Brain, Behavior, and Immunity. ISSN 0889-1591. 118, s. 287–299. doi: 10.1016/j.bbi.2024.03.014. Fulltekst i vitenarkiv Vis sammendrag

  Recent findings link cognitive impairment and inflammatory-immune dysregulation in schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and translation between the periphery and central (blood-to-brain) mechanisms remains a challenge. Starting with a large SZ, BD and healthy control cohort (n = 1235), we aimed to i) identify candidate peripheral markers (n = 25) associated with cognitive domains (n = 9) and elucidate heterogenous immune-cognitive patterns, ii) evaluate the regulation of candidate markers using human induced pluripotent stem cell (iPSC)-derived astrocytes and neural progenitor cells (n = 10), and iii) evaluate candidate marker messenger RNA expression in leukocytes using microarray in available data from a subsample of the main cohort (n = 776), and in available RNA-sequencing deconvolution analysis of postmortem brain samples (n = 474) from the CommonMind Consortium (CMC). We identified transdiagnostic subgroups based on covariance between cognitive domains (measures of speed and verbal learning) and peripheral markers reflecting inflammatory response (CRP, sTNFR1, YKL-40), innate immune activation (MIF) and extracellular matrix remodelling (YKL-40, CatS). Of the candidate markers there was considerable variance in secretion of YKL-40 in iPSC-derived astrocytes and neural progenitor cells in SZ compared to HC. Further, we provide evidence of dysregulated RNA expression of genes encoding YKL-40 and related signalling pathways in a high neuroinflammatory subgroup in the postmortem brain samples. Our findings suggest a relationship between peripheral inflammatory-immune activity and cognitive impairment, and highlight YKL-40 as a potential marker of cognitive functioning in a subgroup of individuals with severe mental illness.

• Teigset, Charlotte Margrethe; Mohn, Hanne Christine; Mohn-Haugen, Caroline Ranem; Larøi, Frank & Rund, Bjørn Rishovd (2024). Psychological and social difficulties in young non-help-seeking adolescents at risk for psychosis: insights from a large cohort study. Frontiers in Psychology. 15. doi: 10.3389/fpsyg.2024.1430805. Fulltekst i vitenarkiv Vis sammendrag

  Background: This study used data from the Norwegian Mother, Father, and Child Cohort Study (MoBa), and explored the psychological and social challenges of 14-year-olds who report psychotic symptoms. Research on help-seeking youths indicates comorbid symptoms of depression, anxiety, and social deterioration, but less is known about non-help-seeking individuals who may not use healthcare services, possibly skewing comorbidity profiles. Also, findings suggest that adolescents manifesting psychotic symptoms refrain from pursuing help. This gap underscores the necessity of studying non-help-seeking adolescents to better understand their needs and the risks they face without intervention. Methods: We analyzed responses from adolescents who completed the 14-year questionnaire in MoBa (N = 127), identifying those as at risk by their high scores on psychosis-risk items, within the top 0.4% (N = 58). Comparative analyses were conducted against matched controls to assess differences in psychological and social functioning (N = 69). Results: Results indicated that the at-risk adolescents experience significantly more depression and anxiety and have lower self-esteem and poorer social functioning than controls. Social functioning parameters, including leisure activities, social competence, quality of parental relationship, and sense of school belonging, were significantly worse than those observed in controls. The results indicate a pronounced vulnerability among non-help-seeking adolescents at-risk, similar to issues seen in help-seeking youths. Conclusion: These findings highlight the importance of early identification and intervention strategies that reach beyond traditional clinical settings, suggesting the efficacy of population or community-based screenings to prevent long-term adverse outcomes. The study proposes a broader understanding of psychosis risk, stressing the importance of inclusive approaches to support at-risk adolescents effectively.

• Mohn, Christine; Ueland, Torill; Haatveit, Beathe; Sæther, Linn Sofie; Lagerberg, Trine Vik & Andreassen, Ole A. [Vis alle 8 forfattere av denne artikkelen] (2024). Neurocognitive function and delusion severity in schizophrenia spectrum disorders. Schizophrenia Research. ISSN 0920-9964. 270, s. 172–177. doi: 10.1016/j.schres.2024.06.028. Fulltekst i vitenarkiv
• Sellevåg, Kjersti; Bartz-Johannessen, Christoffer; Ødegaard, Ketil Joachim; Nordenskjöld, Axel; Mohn, Hanne Christine & Bjørke, Jeanette [Vis alle 7 forfattere av denne artikkelen] (2024). Unmasking Patient Diversity: Exploring Cognitive and Antidepressive Effects of Electroconvulsive Therapy. European psychiatry. ISSN 0924-9338. 67(1), s. 1–9. doi: 10.1192/j.eurpsy.2024.1. Fulltekst i vitenarkiv Vis sammendrag

  Background Electroconvulsive therapy (ECT) is an established treatment for depression, but more data on effectiveness and safety in clinical practice is needed. The aim of this register-based study was to investigate short-term effectiveness and cognitive safety after ECT, evaluated by clinicians and patients. Secondary, we investigated predictors for remission and cognitive decline. Methods The study included 392 patients from the Regional Register for Neurostimulation Treatment in Western Norway. Depressive symptoms and cognitive function were assessed with Montgomery-Åsberg Depression Rating Scale and Mini-Mental State Examination (clinician-rated) and Beck Depression Inventory and Everyday Memory Questionnaire (patient-rated). Assessments were done prior to ECT-series and a mean of 1.7 days after (range 6 days before and 12 days after) end of ECT-series. Paired samples t-tests were extended by detailed, clinically relevant subgroups. Predictors were examined using logistic regression. Results Clinician- and patient-rated remission rates were 49.5 and 41.0%, respectively. There was a large reduction in depressive symptoms and a small improvement in cognition after ECT, but we also identified subgroups with non-response of ECT in combination with cognitive decline (4.6% clinician-rated, 15.7% patient-rated). Positive predictors for patient- and clinician-rated remission were increasing age, shorter duration of depressive episode, and psychotic features. Antipsychotic medication at the commencement of treatment and previous ECT-treatment gave higher odds of clinician-rated remission, whereas higher pretreatment subjective depression level was associated with lower odds for patient-rated remission. Clinician-rated cognitive decline was predicted by higher pretreatment MMSE scores, whereas psychotic features, increasing age, and greater pretreatment subjective memory concerns were associated with lower odds for patient-rated cognitive decline. Conclusions Our study supports ECT as an effective and safe treatment, although subgroups have a less favorable outcome. ECT should be considered at an early stage for older patients suffering from depression with psychotic features. Providing comprehensive and balanced information from clinicians and patients perspectives on effects and side effects, may assist in a joint consent process.

• Sæther, Linn Sofie; Ueland, Thor; Haatveit, Beathe; Vaskinn, Anja; Flaaten, Camilla Bärthel & Mohn, Hanne Christine [Vis alle 12 forfattere av denne artikkelen] (2024). Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls. Psychological Medicine. ISSN 0033-2917. 54, s. 3519–3529. doi: 10.1017/S003329172400206X. Fulltekst i vitenarkiv Vis sammendrag

  Background - While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) and bipolar (BD) spectrum disorders. There is however, limited knowledge about the longitudinal course of this relationship.<p> <p>Methods - Systemic inflammation (C-Reactive Protein, CRP) and cognition (nine cognitive domains) was measured from baseline to 1 year follow-up in first treatment SZ and BD (n = 221), and healthy controls (HC, n = 220). Linear mixed models were used to evaluate longitudinal changes separately in CRP and cognitive domains specific to diagnostic status (SZ, BD, HC). Hierarchical clustering was applied on the entire sample to investigate the longitudinal course of transdiagnostic inflammatory-cognitive subgroups.<p> <p>Results - There were no case-control differences or change in CRP from baseline to follow-up. We confirm previous observations of case-control differences in cognition at both time-points and domain specific stability/improvement over time regardless of diagnostic status. We identified transdiagnostic inflammatory-cognitive subgroups at baseline with differing demographics and clinical severity. Despite improvement in cognition, symptoms and functioning, the higher inflammation – lower cognition subgroup (75% SZ; 48% BD; 38% HC) had sustained inflammation and lower cognition, more symptoms, and lower functioning (SMI only) at follow-up. This was in comparison to a lower inflammation – higher cognition subgroup (25% SZ, 52% BD, 62% HC), where SMI participants showed cognitive functioning at HC level with a positive clinical course.<p> <p>Conclusions - Our findings support heterogenous and transdiagnostic inflammatory-cognitive subgroups that are stable over time, and may benefit from targeted interventions.

• Helldin, Lars; Mohn, Hanne Christine; Olsson-Tall, Maivor; Härd, I.F. Van Dijk & Olsson, Anna-Karin (2024). Extended lifetime expectancy in schizophrenia, role of measurement based care. Archives of Psychiatric Nursing. ISSN 0883-9417. 53, s. 151–157. doi: 10.1016/j.apnu.2024.10.012. Fulltekst i vitenarkiv Vis sammendrag

  Lifespan in schizophrenia spectrum disorders (SSD) is up to 20 years shorter than average. Introduction of new antipsychotic pharmaceuticals has not made any major improvement. Parallel care is provided as usual standard care (USD) in out-patients settings. The study aim was to evaluate if inclusion of Measurement Based Care (MBC) may prolong patients' lifespan. In total, 171 patients were followed with annual semi-structured examinations of psychiatric status, social situation, and somatic illnesses over 20 years, by case managers. Findings indicate that MBC contributed to prolonged lifespan in SSD from 55.6 to 69.4 years from beginning to end of the study.

• Mohn, Hanne Christine; Haga, Egil; Nilsson, Hanne Sofie Wernø; Pirkis, Jane & Mehlum, Lars (2024). Change in attitudes after a suicide prevention media campaign in the Mid-Norway region. BMC Psychiatry. 24(1). doi: 10.1186/s12888-024-05905-x. Fulltekst i vitenarkiv Vis sammendrag

  Background Suicide prevention media campaigns are one way of reaching people at increased suicide risk who would otherwise not seek help. This is the first study of a Norwegian campaign directed both at individuals at risk for suicide and at their social network. Methods We evaluated a media campaign consisting of outdoor posters, feature articles, film clips, and online banners in print, digital, and social media spread across the Mid-Norway region in late autumn 2022. This campaign material consisted of information about how to seek help for suicide thoughts and mental health problems and how to help a friend in similar situations. Before and after this campaign, 1149 adult individuals living in Mid-Norway participated in a survey on attitudes to suicide, mental ill health, and help-seeking. Results There were only marginal changes in attitudes and help-seeking literacy after the campaign. This result was sustained when controlling for age, sex, and campaign visibility. For males, there were a few changes in the negative direction, i.e. lack of willingness to seek help from family and friends, after the campaign. Conclusion We conclude that the campaign did not seem to have the desired effect and suggest ways of improving future regional Norwegian media campaigns.

• Mohn, Hanne Christine; Olsson, Anna-Karin; Härd, I.F. Van Dijk & Helldin, Lars (2023). Neurocognitive function and mortality in patients with schizophrenia spectrum disorders. Schizophrenia Research: Cognition. 33. doi: 10.1016/j.scog.2023.100284. Fulltekst i vitenarkiv Vis sammendrag

  Individuals with schizophrenia spectrum disorders (SSD) have significantly lower life-expectancy than healthy people. Previously, we have identified baseline neurocognitive function in general and verbal memory and executive function in particular as related to mortality nearly two decades later. In this study, we aim to replicate these findings with a larger and age-matched sample. The patient group consisted of 252 individuals, 44 of whom were deceased and 206 alive. Neurocognition was assessed with a comprehensive battery. Results showed that the deceased group, compared to the living group, had significantly more severe neurocognitive deficits across nearly all domains. There were no differences in sex, remission status, psychosis symptoms, or function level between the groups. Immediate verbal memory and executive function were the strongest predictors of survival status. These results were nearly identical to our previous studies, and we conclude that baseline neurocognitive function is an important predictor for mortality in SSD. Clinicians should be mindful of this relationship in patients with significant cognitive deficits.

• Wootton, Olivia; Shadrin, Alexey; Mohn, Christine; Susser, Ezra; Ramesar, Raj & Gur, Ruben C. [Vis alle 9 forfattere av denne artikkelen] (2023). Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-023-02292-9. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many neuropsychiatric disorders. There have been no large-scale genome-wide association studies (GWAS) of RTV and little is known about its genetic underpinnings. Here, we used data from the UK Biobank to conduct a GWAS of RTV in participants of white British ancestry ( n  = 404,302) as well as a trans-ancestry GWAS meta-analysis ( n  = 44,873) to assess replication. We found 161 genome-wide significant single nucleotide polymorphisms (SNPs) distributed across 7 genomic loci in our discovery GWAS. Functional annotation of the variants implicated genes involved in synaptic function and neural development. The SNP-based heritability ( h 2 SNP ) estimate for RTV was 3%. We investigated genetic correlations between RTV and selected neuropsychological traits using linkage disequilibrium score regression, and found significant correlations with several traits, including a positive correlation with mean reaction time and schizophrenia. Despite the high genetic correlation between RTV and mean reaction time, we demonstrate distinctions in the genetic underpinnings of these traits. Lastly, we assessed the predictive ability of a polygenic score (PGS) for RTV, calculated using PRSice and PRS-CS, and found that the RTV-PGS significantly predicted RTV in independent cohorts, but that the generalisability to other ancestry groups was poor. These results identify genetic underpinnings of RTV, and support the use of RTV as an endophenotype for neurological and psychiatric disorders.

• Torgalsbøen, Anne Kari; Mohn, Christine; Larøi, Frank; Fu, Susie & Czajkowski, Nikolai Olavi (2023). A ten-year longitudinal repeated assessment study of cognitive improvement in patients with first-episode schizophrenia and healthy controls: The Oslo Schizophrenia Recovery (OSR) study. Schizophrenia Research. ISSN 0920-9964. 260, s. 92–98. doi: 10.1016/j.schres.2023.08.008. Fulltekst i vitenarkiv Vis sammendrag

  The mapping of cognitive trajectories after a first episode of schizophrenia has been the aim in several studies, but the longitudinal course of cognitive impairments remains an important question. Due to methodological limitations, it has been challenging to pinpoint specific periods of improvement or stability in cognitive functioning over time. The objective of this study is to further clarify the longitudinal course of cognitive change after a first episode of schizophrenia through frequent repeated measurement. A total of 56 persons participated in the study (28 first episode patients and 28 healthy pairwise matched controls) with 79 % of patients retained at the 10-year follow-up. The Oslo Schizophrenia Recovery study has a repeated measurement design and includes data from nine cognitive assessments over 10 years. Cognition was assessed with the MATRICS Consensus Cognitive Battery, which is well suited for repeated measurements. Data were analyzed with linear multilevel models. The results challenge some of the views about the course of cognitive impairment in first-episode schizophrenia patients. Using quadratic time effects in our analyses and balancing the patient group with regards to the most relevant confounding demographic variables such as age, gender, and education, we showed that cognitive deficits change and improve more than in healthy individuals until year 6, when both groups stabilize. The patient group improved on some of the most important cognitive domains associated with functional outcome with 63.5 % full recovery at 10-year follow-up.

• Haatveit, Beathe; Westlye, Lars Tjelta; Vaskinn, Anja; Flaaten, Camilla Bärthel; Mohn, Hanne Christine & Bjella, Thomas [Vis alle 12 forfattere av denne artikkelen] (2023). Intra- and inter-individual cognitive variability in schizophrenia and bipolar spectrum disorder: an investigation across multiple cognitive domains. Schizophrenia. 9(1). doi: 10.1038/s41537-023-00414-4. Fulltekst i vitenarkiv Vis sammendrag

  There is substantial cognitive heterogeneity among patients with schizophrenia (SZ) and bipolar disorders (BD). More knowledge about the magnitude and clinical correlates of performance variability could improve our understanding of cognitive impairments. Using double generalized linear models (DGLMs) we investigated cognitive mean and variability differences between patients with SZ (n = 905) and BD spectrum disorders (n = 522), and healthy controls (HC, n = 1170) on twenty-two variables. The analysis revealed significant case-control differences on 90% of the variables. Compared to HC, patients showed larger intra-individual (within subject) variability across tests and larger inter-individual (between subject) variability in measures of fine-motor speed, mental processing speed, and inhibitory control (SZ and BD), and in verbal learning and memory and intellectual functioning (SZ). In SZ, we found that lager intra -and inter (on inhibitory control and speed functions) individual variability, was associated with lower functioning and more negative symptoms. Inter-individual variability on single measures of memory and intellectual function was additionally associated with disorganized and positive symptoms, and use of antidepressants. In BD, there were no within-subject associations with symptom severity. However, greater inter-individual variability (primarily on inhibitory control and speeded functions) was associated with lower functioning, more negative -and disorganized symptoms, earlier age at onset, longer duration of illness, and increased medication use. These results highlight larger individual differences in patients compared to controls on various cognitive domains. Further investigations of the causes and correlates of individual differences in cognitive function are warranted.

• Mohn-Haugen, Caroline Ranem; Møller, Paul; Mohn, Christine; Larøi, Frank; Teigset, Charlotte Margrethe & Øie, Merete Glenne [Vis alle 7 forfattere av denne artikkelen] (2023). Anomalous self-experiences and neurocognitive functioning in adolescents at risk for psychosis: Still no significant associations found between these two vulnerability markers. Comprehensive Psychiatry. ISSN 0010-440X. 125. doi: 10.1016/j.comppsych.2023.152400. Fulltekst i vitenarkiv Vis sammendrag

  Background Anomalous self-experiences (ASEs) and neurocognitive impairments are considered essential domains of vulnerability for developing psychotic disorders. However, little research exists of possible associations between ASEs and neurocognitive functions in individuals at-risk for psychosis. The interconnections between ASEs and neurocognitive impairments should therefore be clarified as much as possible, especially in young individuals at risk. No previous studies have investigated these two fundamental domains in non-help-seeking adolescents at risk for developing psychosis. Methods This study is based on the Norwegian Mother, Father and Child Cohort Study (MoBa). Adolescents (N = 48, 94% females, mean age = 15.3) were invited to participate after completing a 14-year-old survey distributed by MoBA. At-risk adolescents were selected based on the 0.4% highest scores on 19 items assessing both psychotic-like experiences and ASEs. Five specifically selected and formulated items measuring ASEs were computed to an ASEs total score. Neurocognitive functioning was assessed using the MATRICS Consensus Cognitive Battery. Results Regression analyses revealed no significant relationships between ASEs and any neurocognitive domain. Conclusions We did not find any significant associations between ASEs and neurocognitive functions in non-help-seeking adolescents at risk for psychotic disorders, which is in line with reports from other types of cohorts. Thus, ASEs and neurocognitive functions may be understood as two relatively separate domains that co-exist in at-risk states. These results underline the need for a wider scope when making predictions about future trajectories, e.g. the development of psychotic disorders. Including both ASEs and neurocognitive functioning in at-risk populations may increase the specificity of vulnerability criteria in this population and enhance our understanding of early psychosis psychopathology.

• Sæther, Linn Sofie; Ueland, Thor; Haatveit, Beathe; Maglanoc, Luigi; Szabo, Attila & Djurovic, Srdjan [Vis alle 15 forfattere av denne artikkelen] (2022). Inflammation and cognition in severe mental illness: patterns of covariation and subgroups. Molecular Psychiatry. ISSN 1359-4184. 8, s. 1284–1292. doi: 10.1038/s41380-022-01924-w. Fulltekst i vitenarkiv Vis sammendrag

  A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for inter-individual variance in both cognitive functioning and inflammatory/immune status. This study aimed to investigate covariance patterns between inflammatory/immune-related markers and cognitive domains and further elucidate heterogeneity in a large SMI and healthy control (HC) cohort (SZ = 343, BD = 289, HC = 770). We applied canonical correlation analysis (CCA) to identify modes of maximum covariation between a comprehensive selection of cognitive domains and inflammatory/immune markers. We found that poor verbal learning and psychomotor processing speed was associated with higher levels of interleukin-18 system cytokines and beta defensin 2, reflecting enhanced activation of innate immunity, a pattern augmented in SMI compared to HC. Applying hierarchical clustering on covariance patterns identified by the CCA revealed a high cognition—low immune dysregulation subgroup with predominantly HC (24% SZ, 45% BD, 74% HC) and a low cognition—high immune dysregulation subgroup predominantly consisting of SMI patients (76% SZ, 55% BD, 26% HC). These subgroups differed in IQ, years of education, age, CRP, BMI (all groups), level of functioning, symptoms and defined daily dose (DDD) of antipsychotics (SMI cohort). Our findings suggest a link between cognitive impairment and innate immune dysregulation in a subset of individuals with severe mental illness.

• Mohn-Haugen, Caroline Ranem; Mohn, Christine; Larøi, Frank; Teigset, Charlotte; Øie, Merete Glenne & Rund, Bjørn Rishovd (2022). A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders. Schizophrenia Research: Cognition. 28, s. 1–14. doi: 10.1016/j.scog.2022.100246. Fulltekst i vitenarkiv Vis sammendrag

  Cognitive impairments are core features of established schizophrenia spectrum disorders (SSD). However, it remains unclear whether specific cognitive functions are differentially impaired pre-onset and at what age these impairments can be detected. The purpose of this review was to elucidate these issues through a systematic summary of results from longitudinal studies investigating impairment in specific cognitive domains as antecedents of SSD. Relevant studies were identified by electronic and manual literature searches and included any original study of cognitive domains any time pre-onset of SSDs that included a control group. Effect sizes were calculated by domain for studies comparing high-risk participants who developed SSD with those who did not. The strongest evidence for impairment pre-onset was for mental processing speed, verbal learning and memory, executive function, and social cognition. Some verbal impairments, like language abilities at age 3 and verbal learning and memory at age 7, may develop as static deficits. Conversely, some non-verbal impairments, like mental processing speed, visuospatial abilities, and visual working memory manifest as developmental lag and become significant later in life. Most effect sizes were small to moderate, except for verbal fluency (d′ = 0,85), implying this impairment as central in high-risk participants who develop SSD. The present review documents extensive cognitive impairments pre-onset of SSD, and that these impairments start early in life, in line with the neurodevelopmental hypothesis of schizophrenia. Increased knowledge about cognitive impairments preonset can provide a better basis for understanding the complex pathogenesis of SSD as well as informing cognitive remediation programs.

• Mohn-Haugen, Caroline Ranem; Mohn, Hanne Christine; Larøi, Frank; Teigset, Charlotte; Øie, Merete Glenne & Rund, Bjørn Rishovd (2022). Cognitive functioning in a group of adolescents at risk for psychosis. Frontiers in Psychiatry. doi: 10.3389/fpsyt.2022.1075222. Fulltekst i vitenarkiv Vis sammendrag

  Cognitive deficits are a core feature of schizophrenia, and impairments are present in groups at-risk for psychosis. Most at-risk studies include young adults and not younger age-groups, such as adolescents. Participants are usually help-seeking individuals, even though risk factors may also be present in non-help seeking adolescents. We aim to explore cognitive functions in a group of non-help-seeking 15-year-old adolescents at risk for psychosis compared to age- and gender matched controls, including particular focus on specific cognitive domains. Hundred participants (mean age = 15.3) were invited after completing the 14-year-old survey distributed by the Norwegian Mother-, Father- and Child Study. At-risk adolescents were selected based on high scores on 19 items assessing both psychotic experiences and anomalous self-experiences. Matched controls were selected from the same sample. Cognitive functioning was assessed using the MATRICS Consensus Cognitive Battery and IQ using Wechsler’s Abbreviated Test of Intelligence. We found that the adolescents at-risk for psychosis had significantly poorer scores than controls on the composite score of the MCCB. IQ scores were also significantly lower in the at-risk group. The results highlight general cognitive deficits as central in a group of non-help-seeking adolescents at-risk for psychosis. Results indicate that the development of cognitive impairments starts early in life in at-risk groups. It is still unclear whether specific cognitive domains, such as verbal learning, are related to psychotic symptoms or may be specifically vulnerable to symptoms of depression and anxiety.

• Mohn, Christine; Olsson, Anna-Karin; Johansson, Madeleine; Moradi, Hawar & Helldin, Lars (2021). Marginal relationship between affective dispositions and neurocognitive function in patients with schizophrenia spectrum disorders. Nordic Journal of Psychiatry. ISSN 0803-9488. doi: 10.1080/08039488.2020.1862294%3FjournalCode=ipsc20. Fulltekst i vitenarkiv
• Teigset, Charlotte; Mohn, Hanne Christine & Rund, Bjørn Rishovd (2020). Perinatal complications and executive dysfunction in early-onset schizophrenia. BMC Psychiatry. doi: 10.1186/s12888-020-02517-z. Fulltekst i vitenarkiv Vis sammendrag

  Background The present study examined the association between perinatal obstetric complications and executive dysfunction in early-onset schizophrenia (EOS), compared to healthy controls. Higher incidences of obstetric complications and more severe executive dysfunctions characterize EOS. Research shows extensive brain maturation in newborns, suggesting them to be particularly vulnerable for perinatal insults. Executive function is mainly mediated by the prefrontal cortex, an area that matures last during pregnancy. Thus, exposure to perinatal complications may influence executive dysfunction in EOS. Methods The participants were 19 EOS patients and 54 healthy controls. Executive function was assessed with the D-KEFS Color Word Interference Test and the Wisconsin Card Sorting Test. Information on perinatal obstetric complications and Apgar 5-min scores were obtained from the Norwegian Medical Birth Registry. Associations between perinatal conditions and executive function were studied using stepwise regression analyses. Results Perinatal complications, and especially shorter gestational lengths, were significantly associated with significant executive dysfunctions in EOS. Perinatal complications did not affect executive function among healthy controls. A significant relationship between lower Apgar 5-min scores and executive dysfunction was found among both EOS patients and healthy controls. Conclusions Exposure to perinatal complications, and particularly a shorter gestational length, was associated with increased executive dysfunction in EOS. Exposed healthy controls did not exhibit similar executive difficulties, suggesting that the EOS patients seemed especially vulnerable for executive deficits due to perinatal insults. The findings indicate that EOS youths learn more slowly and experience more difficulty with problem-solving, which carry important implications for clinical practice. Lower Apgar 5-min scores were associated with executive dysfunction in both groups. Low Apgar score at 5 min may therefore be an important early indicator of executive difficulties among adolescents, independent of diagnosis.

• Helldin, Lars; Mohn, Christine; Olsson, Anna-Karin & Fredrik, Hjärthag (2020). Neurocognitive variability in schizophrenia spectrum disorders: relationship to real-world functioning. Schizophrenia Research: Cognition. doi: 10.1016/j.scog.2020.100172. Fulltekst i vitenarkiv Vis sammendrag

  Neurocognitive variability exists within the schizophrenia spectrum disorder (SSD) population, with subgroups performing at the same level as healthy samples Here we study the relationship between different levels of neurocognitive responding and real-world functioning. The participants were 291 SSD patients and 302 healthy controls that were assessed with a comprehensive neurocognitive battery. In addition, the patients were assessed with the Specific Level of Functioning Scale (SLOF). The results showed that the mean neurocognitive test responses of the SSD group were significantly below that of the control group. However, there was considerable overlap between the cognitive scores of the two groups, with as many as 24% of the patients performing above the mean healthy score for some domains. Moreover, the patients with the highest level of neurocognitive functioning reached the highest levels of practical and work-related functioning outcome skills. There was no significant relationship between neurocognitive and social function skills. The large differences in cognitive performance and their associations with functional outcome within the patient group are rarely addressed in clinical practice, but indicate a clear need for individualized treatment of SSD. Early identification of cognitive risk factors for poor real-life functional outcome is necessary in order to alert the clinical and rehabilitation services about patients in need of extra care.

• Mohn, Hanne Christine; Olsson, Anna-Karin; Johansson, Madeleine; Moradi, Hawar & Helldin, Lars (2020). Marginal relationship between affective dispositions and neurocognitive function in patients with schizophrenia spectrum disorders. Nordic Journal of Psychiatry. ISSN 0803-9488. doi: 10.1080/08039488.2020.1862294. Fulltekst i vitenarkiv
• Mohn, Christine & Rund, Bjørn Rishovd (2019). Neurognitive function and symptom remission 2 years after ECT in major depressive disorders. Journal of Affective Disorders. ISSN 0165-0327. 246, s. 368–375. doi: 10.1016/j.jad.2018.12.083. Fulltekst i vitenarkiv Vis sammendrag

  Background There is a lack of knowledge of possible cognitive side effects of electroconvulsive therapy (ECT) beyond the first few months after treatment. We aim to describe cognitive effects and symptom remission 2 years after ECT in major depressive disorders. Method Twenty-seven depression patients were assessed with the MATRICS Consensus Cognitive Battery (MCCB) and the Everyday Memory Questionnaire (EMQ) before and 2 years after ECT. Their scores were compared with those of healthy matches. Depression and remission status were assessed with the Montgomery–Åsberg Depression Rating Scale (MADRS). Main statistical analyses were ANOVAs and linear mixed model tests. Results At baseline, the patient group was significantly impaired on 7 of 10 cognitive tests compared to the control group. Two years later, this gap was reduced to impairment on 5 of 10 tests. Within the patient group, neurocognitive function either increased significantly from baseline to follow-up, or there was no change. Two years after ECT, 62.9% of the patients were in remission. Those in remission reported better subjective memory function, but displayed no different neuropsychological test results, compared to the non-remitters. Limitations Major limitations were low sample size and lack of uniform ECT procedure. Conclusions We found improved neurocognitive function 2 years after ECT. This effect occurred regardless of remission status, suggesting that ECT induces unique cognitive boosting processes.

• Mohn, Christine & Torgalsbøen, Anne-Kari (2018). Details of attention and learning change in first-episode schisophrenia. Psychiatry Research. ISSN 0165-1781. 260, s. 324–330. doi: 10.1016/j.psychres.2017.12.001. Fulltekst i vitenarkiv Vis sammendrag

  Impaired attention and learning functions are common in schizophrenia. The details of this impairment, and how these change across time, are not well known. We aimed to compare the parameters of well-known attention and learning neuropsychological tests in first-episode schizophrenia (FES) patients and healthy controls in a 2-year follow-up period. The performance of 28-25 FES patients and pairwise matched healthy controls on the Continuous Performance Test-Identical Pairs, the revised Hopkins Verbal Learning Test, and the revised Brief Visuospatial Memory Test was compared at baseline and 2 years later. The attention dysfunction of the FES group was driven by slow reaction time and a comparative failure to identify correct hits. The reaction time was reduced somewhat across time in the patient group. Regarding the learning tasks, both groups increased their number of correct answers across trials. However, at each trial, the patient group exhibited lower scores, with a trend towards better visual learning performance across time. In summary, the FES patients were impaired in most of the parameters of the attention and learning tasks. Across time, modest improvements in reaction time and visual learning were displayed in the FES group. However, this group never caught up with the control group.

• Engelstad, Katharina Nymo; Vaskinn, Anja; Torgalsbøen, Anne-Kari; Mohn, Christine; Lau, Bjørn & Rund, Bjørn Rishovd (2018). Impaired Neuropsychological Profile in Homicide Offenders with Schizophrenia. Comprehensive Psychiatry. ISSN 0010-440X. 85, s. 55–60. doi: 10.1016/j.comppsych.2018.06.002. Fulltekst i vitenarkiv Vis sammendrag

  Background: Our ability to predict and prevent homicides committed by individuals with schizophrenia is limited. Cognitive impairments are associated with poorer functional outcome in schizophrenia, possibly also homicide. The aim of the current study was to investigate global and specific cognition among homicide offenders with schizophrenia (HOS). Methods: Twenty-six HOS were compared to 28 individuals with schizophrenia and no history of violence (non-HOS), and a group of healthy controls (HC, n = 151). HOS and non-HOS participants were recruited from in- and outpatient units across Norway. An extensive neuropsychological test battery was administered. Results: HOS participants performed significantly weaker than HC in all cognitive domains. Further, statistically significant differences between HOS and non-HOS participants were found for IQ (d = 0.52) and verbal learning (d = 0.82), with larger impairments in the HOS compared to the non-HOS group. Conclusions: Our results indicate that HOS participants show clinically significant impairments in global and specific cognition.

• Teigset, Charlotte; Mohn, Christine; Brunborg, Cathrine; Juuhl-Langseth, Monica; Holmen, Aina & Rund, Bjørn Rishovd (2018). Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? Journal of Child Psychology and Psychiatry. ISSN 0021-9630. 59(9), s. 1012–1023. doi: 10.1111/jcpp.12896. Fulltekst i vitenarkiv Vis sammendrag

  Background Being in a period with extensive brain maturation, adolescents with early‐onset schizophrenia‐spectrum disorders (EOS) provide unique neurodevelopmental data that may contribute to a better understanding of schizophrenia at all ages. Cognitive dysfunction is a central feature of schizophrenia and is more pronounced in EOS than in later onset illness. However, there is limited research on both the long‐term course of global cognition in EOS, and how cognition over time is influenced by clinical characteristics during the early illness period. Methods Thirty‐one EOS patients and 73 controls (age 12–18) were assessed on clinical variables at baseline (PANSS, duration of untreated psychosis [DUP], hospitalizations, suicide attempts, and remission). Neuropsychological assessments with the MATRICS Consensus Cognitive Battery (MCCB) were conducted at baseline and after both 1 and 2 years, and composite scores of total performances were calculated. The analyses were performed with a linear mixed model. Results The present study found that global cognition followed a stable course over the first years of the disease in EOS, though at a significantly lower level in EOS compared with the controls. We did not detect a relationship between DUP, remission, positive/negative symptoms, and hospitalizations on one hand, and long‐term cognition on the other hand, but PANSS‐general and suicide attempt history at baseline were identified as risk factors of longitudinal cognitive function. Conclusions Though at different levels, the EOS group and the controls had a similar cognitive course over 2 years. Some baseline characteristics (psychotic symptoms, DUP, remission, and hospitalization) had no influence on cognition within the first 2 years of illness. In contrast, general symptoms and a history of suicide attempts at baseline were more potent risk factors of the cognitive course than the psychotic‐specific symptoms, and should, therefore, be subject to specific attention in the evaluation and treatment of patients with early‐onset psychosis.

• Mohn, Christine; Olsson, Anna-Karin & Helldin, Lars (2018). Positive and negative affect in schizophrenia spectrum disorders: A forgotten dimension? Psychiatry Research. ISSN 0165-1781. 267, s. 148–153. doi: 10.1016/j.psychres.2018.05.060. Fulltekst i vitenarkiv
• Mohn, Christine; Lystad, June Ullevoldsæter; Ueland, Torill; Falkum, Erik & Rund, Bjørn Rishovd (2017). Factor analyzing the Norwegian MATRICS Consensus Cognitive Battery. Psychiatry and Clinical Neurosciences. ISSN 1323-1316. 71(5), s. 336–345. doi: 10.1111/pcn.12513. Fulltekst i vitenarkiv Vis sammendrag

  Aim: The MATRICS Consensus Cognitive Battery (MCCB) assesses seven cognitive domains with 10 subtests. This domain structure has not been demonstrated. Three factors have been produced in US samples. We examined the dimensional structure of the Norwegian MCCB. In addition, we studied the contribution of each subtest to the battery sum score. Methods: The participants were 131 patients with schizophrenia spectrum disorders and 300 healthy controls. Their Norwegian MCCB test scores were subject to exploratory and confirmatory factor analysis and regression analysis. Results: The theoretical MCCB factor structure was not shown. In the patient group, three‐factor and two‐factor models had acceptable fit. In both groups, the Symbol Coding, Spatial Span, Letter–Number Span, and Visual Learning subtests contributed most to the sum score. Conclusion: The theoretical domain structure of the MCCB could not be demonstrated in these Norwegian participants. Consonant with US studies, models with three and two factors had mediocre fit, and in the schizophrenia spectrum disorder group only. In both groups, the subtests Symbol Coding, Working Memory, and Learning were the most sensitive in tapping general neurocognitive performance, supporting US results. We conclude that in both Norway and the USA, the MCCB generates the same cognitive domains through factor analysis, but that these domains are not the ones suggested by the MATRICS project. This research has been published in Psychiatry and Clinical Neurosciences. © 2017 Wiley

• Mohn, Christine (2017). Kognitive effekter av ECT ved depresjonslidelser. Nevropsykologi : Medlemsblad for Norsk Nevropsykologisk Forening. ISSN 1500-8347. 2. Fulltekst i vitenarkiv
• Mohn, Christine & Torgalsbøen, Anne-Kari (2017). Details of attention and learning change in first-episode schizophrenia. Psychiatry Research. ISSN 0165-1781. 260, s. 324–330. doi: 10.1016/j.psychres.2017.12.00. Fulltekst i vitenarkiv
• Mohn, Christine & Rund, Bjørn Rishovd (2016). Maintained Improvement of Neurocognitive Function in Major Depressive Disorders 6 Months after ECT. Frontiers in Psychiatry. 7. doi: 10.3389/fpsyt.2016.00200. Fulltekst i vitenarkiv
• Mohn, Christine & Rund, Bjørn Rishovd (2016). Neurocognitive profile in major depressive disorders: relationship to symptom level and subjective memory complaints. BMC Psychiatry. 16(1). doi: 10.1186/s12888-016-0815-8. Fulltekst i vitenarkiv Vis sammendrag

  Background The MATRICS Consensus Cognitive Battery (MCCB) was developed for schizophrenia patients, but is also being used to assess neurocognitive function in bipolar disorder. This study aims to describe neurocognitive differences in major depressive disorder patients and healthy controls with the MCCB, and to describe the relationship between depression symptom severity, subjective cognitive complaints, and objective cognitive test performance. Methods Thirty-three patients with major depressive disorder and 33 pairwise matched healthy controls were assessed with the MCCB. The patients were also assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Everyday Memory Questionnaire (EMQ). Results On all neurocognitive domains, the depression patients scored significantly lower than the controls. The level of impairment ranged from 21.0 % (Working Memory) to 58.0 % (Speed of Processing). There were significant associations between neurocognitive test performance and depression symptom severity, but not with subjective cognitive complaints. Conclusions The MCCB was applicable in this study of major depressive disorder, and revealed significant neurocognitive dysfunction in this group. At least one fifth of the patients were impaired on all cognitive domains, with Speed of Processing and Reasoning/Problem Solving being most strongly affected. The objective test scores were significantly related to depression severity, but not to subjective cognitive complaints.

• Mohn, Christine & Rund, Bjørn Rishovd (2016). Significantly improved neurocognitive function in major depressive disorders 6 weeks after ECT. Journal of Affective Disorders. ISSN 0165-0327. 202, s. 10–15. doi: 10.1016/j.jad.2016.03.062. Fulltekst i vitenarkiv
• Teigset, Charlotte; Mohn, Christine & Rund, Bjørn Rishovd (2016). Gestational length affects neurocognition in early-onset schizophrenia. Psychiatry Research. ISSN 0165-1781. 244, s. 78–85. doi: 10.1016/j.psychres.2016.07.017. Fulltekst i vitenarkiv
• Torgalsbøen, Anne-Kari; Mohn, Christine; Czajkowski, Nikolai Olavi & Rund, Bjørn Rishovd (2015). Relationship between neurocognition and functional recovery in first-episode schizophrenia: Results from the second year of the Oslo multi-follow-up study. Psychiatry Research. ISSN 0165-1781. 227(2-3), s. 185–191. doi: 10.1016/j.psychres.2015.03.037. Fulltekst i vitenarkiv
• Torgalsbøen, Anne-Kari; Mohn, Christine & Rund, Bjørn Rishovd (2014). Neurocognitive predictors of remission of symptoms and social and role functioning in the early course of first-episode schizophrenia. Psychiatry Research. ISSN 0165-1781. 216(1), s. 1–5. doi: 10.1016/j.psychres.2014.01.031. Fulltekst i vitenarkiv
• Lystad, June; Falkum, Erik; Mohn, Christine; Haaland, Vegard Øksendal; Bull, Helen & Evensen, Stig [Vis alle 8 forfattere av denne artikkelen] (2014). The MATRICS Consensus Cognitive Battery (MCCB): Performance and functional correlates. Psychiatry Research. ISSN 0165-1781. 220(3), s. 1094–1101. doi: 10.1016/j.psychres.2014.08.060. Fulltekst i vitenarkiv
• Mohn, Christine; Sundet, Kjetil Søren & Rund, Bjørn Rishovd (2014). The relationship between IQ and performance on the MATRICS Consensus Cognitive Battery. Schizophrenia Research: Cognition. 1, s. 96–100. doi: 10.1016/j.scog.2014.06.003. Fulltekst i vitenarkiv
• Mohn, Christine; Sundet, Kjetil Søren & Rund, Bjørn Rishovd (2013). Standardisering av MATRICS Consensus Cognitive Battery (MCCB) for bruk i Norge. Tidsskrift for Norsk psykologforening (Psykologtidsskriftet). ISSN 0332-6470. 50, s. 989–991. Fulltekst i vitenarkiv
• Mohn, Christine; Vassend, Olav & Knardahl, Stein (2012). Cardiovascular responses to and modulation of pressure pain sensitivity in normotensive, pain-free women. Scandinavian Journal of Pain. ISSN 1877-8860. 3(3), s. 165–169. doi: 10.1016/j.sjpain.2011.12.001. Fulltekst i vitenarkiv Vis sammendrag

  Background and purpose: The psychophysiological responses to and modulation of pressure pain stimulation are relatively new areas of investigation. The aims of the present study were to characterize subjective and cardiovascular (CV) responses to pressure pain stimulation, and to examine the relationship between CV responding and pain pressure pain sensitivity. Methods: Thirty-nine pain-free, normotensive women were included in the study and tested during the follicular phase of their menstrual cycles. Pain threshold and tolerance were recorded at the right masseter muscle and the sternum, and visual analogue scales (VAS) were used to rate both pain intensity (the sensory dimension) and discomfort (the affective dimension). Mean arterial pressure (MAP), heart rate (HR), and facial and digital skin blood flux (SBF) were registered continuously. Results: The pain threshold and tolerance were significantly higher at the sternum compared with the masseter, but the level of affective distress was higher at the masseter tolerance point. No associations emerged between pressure pain threshold and tolerance stimulation levels, and the corresponding VAS ratings. Pressure pain stimulation of the masseter induced significant increases in MAP, HR, and a decrease in digital SBF. During sternum pressure stimulation a significant change in HR and digital SBF was observed. There were no significant correlations between CV responding and pressure pain sensitivity. Conclusion: Healthy women seem to display higher pressure pain sensitivity at the masseter region relative to the sternum. Pressure pain stimulation was associated with significant changes in MAP, HR, and SBF, but was not modulated by CV responses. The validity of these findings is strengthened by our control for menstrual cycle events, weekend-related changes in physiology, and CV changes during pain stimulation. Implications: This study extends previous reports of SBF sensitivity to electrocutaneous pain into the field of pressure stimulation. Moreover, this study suggests that the often demonstrated association between high BP and low pain sensitivity may not apply to pressure pain specifically. Alternatively, this finding adds to the literature of gender differences in the relationship between CV responding and acute pain sensitivity in general.

• Mohn, Christine; Sundet, Kjetil Søren & Rund, Bjørn Rishovd (2012). The Norwegian standardization of the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Consensus Cognitive Battery. Journal of Clinical and Experimental Neuropsychology. ISSN 1380-3395. 34(6), s. 667–677. doi: 10.1080/13803395.2012.667792. Fulltekst i vitenarkiv
• Mohn, Christine; Vassend, Olav & Knardahl, Stein (2011). Psychophysiological responses to pain stimulation and cognitive tasks in female temporomandibular disorder patients. Scandinavian Journal of Pain. ISSN 1877-8860. 2(2), s. 72–82. doi: 10.1016/j.sjpain.2010.12.001. Fulltekst i vitenarkiv Vis sammendrag

  Background and purpose Psychophysiological factors may contribute to the development of temporomandibular disorders (TMD). Both local orofacial and systemic responses have been investigated. However, most studies have concentrated on physiological responding during cognitive challenges, while responses during painful tasks may be highly relevant for the development of chronic pain conditions. Moreover, the relationship between experimental challenges and physiological responding may be influenced by affective responses during the experimental tasks, an issue not often considered in the literature. Methods This study compared electromyography (EMG) of the left masseter and left trapezius muscles, orofacial and digital skin blood-flow (SBF), mean arterial pressure (MAP), and heart rate (HR) at rest, during orofacial isometric contraction, electrocutaneous pain stimulation of the left hand, pressure pain stimulation of the masseter muscle and the sternum, and three cognitive tasks (reading aloud, a simulated job interview, and visuomotoric tracking). The participants were 25 TMD patients and 25 matched pain-free controls, all females. Affective responses were assessed with the State part of the State-Trait Personality Inventory and with Visual Analogue Scales. Results Masseter EMG levels were significantly lower in the TMD group relative to the control group during jaw contraction, pressure pain stimulation, the relaxation periods, and cognitive tasks. SBF, MAP, and HR responses were largely similar in the two groups, with SBF responses to pain stimulation evident at lower levels of stimulation than previously found. The TMD patients reported significantly higher levels of negative affect during the experiment. Conclusions and implications The low EMG responses in the TMD group may be taken in support of the Pain Adaptation Model of musculoskeletal pain, in which reduced muscular activity serves to protect a painful area. However, it may also be supportive of the Integrated Pain Adaptation Model, where higher central nervous structures influence local muscular output. The group similarities in systemic physiological responding in combination with the elevated levels of negative state affect in the TMD patients confirm previous reports of psychosocial differences being more reliable indicators of TMD than generalized physiological responding.

• Mohn, Christine; Argstatter, Heike & Wilker, Friedrich-Wilhelm (2011). Perception of six basic emotions in music. Psychology of Music. ISSN 0305-7356. 39(4), s. 503–517. doi: 10.1177/0305735610378183. Fulltekst i vitenarkiv
• Mohn, Christine; Vassend, Olav; Krogstad, Berit Heyerdahl & Knardahl, Stein (2010). Personality traits and subjective health complaints in female TMD patients and healthy controls. The Open Pain Journal. 3, s. 134–143. doi: 10.2174/1876386301003010134. Fulltekst i vitenarkiv Vis sammendrag

  Abstract: Background: Personality traits and general health complaints may influence the course of and treatment of chronic pain. However, only few studies compare more than one or two personality characteristics in chronic pain patients and healthy controls. This study compares the comprehensive non-pathological personality structure of female patients with temporomandibular disorders (TMD) and pain-free controls. Moreover, this study controls for the influence of Neuroticism, self-presentation bias, and acute pain sensitivity on the subjective report of general health complaints. Methods: Twenty-five TMD patients were compared to 25 matched controls on personality traits (NEO Personality Inventory-Revised; NEO-PI-R), self-presentation bias (Social Desirability Scale; SDS), psychological distress (Symptom Checklist 90-Revised; SCL-90-R), and general somatic complaints. Experimental pain sensitivity was assessed by electrocutaneous and pressure pain stimulation. Results: Compared to the controls, Extraversion and Openness were lower in the TMD group, and the TMD patients exhibited higher levels of psychological and musculoskeletal complaints also when Neuroticism, self-presentation bias, and acute pain sensitivity were held constant. Conclusions: Low levels of Extraversion and Openness may dispose TMD patients to isolation and negative thought patterns. The elevated levels of psychological distress and general musculoskeletal pain in the TMD group add to previous reports of TMD as a complex condition also involving structures and processes outside of the orofacial region.

• Mohn, Christine; Vassend, Olav & Knardahl, Stein (2008). Experimental pain sensitivity in women with temporomandibular disorders and pain-free controls: the relationship to orofacial muscular contraction and cardiovascular responses. The Clinical Journal of Pain. ISSN 0749-8047. 24(4), s. 343–352. doi: 10.1097/AJP.0b013e318162eaf4. Fulltekst i vitenarkiv Vis sammendrag

  OBJECTIVE: Chronic pain may result both from a generalized hypersensitivity to acute pain, suggestive of central sensitization processes, and dysfunction of the endogenous pain regulatory system. One purpose of this study was to compare experimental pain sensitivity at several anatomic sites in temporomandibular disorder (TMD) patients and pain-free controls during baseline and after standardized mechanical load of the orofacial region. A second purpose was to compare the pain-modulating effects of cardiovascular responses in TMD patients and pain-free controls. METHODS: Experimental pain was induced by electrocutaneous stimulation of the dorsal left hand and pressure algometry at the right masseter muscle and the sternum. The pain sensitivity of the orofacial region was manipulated by isometric contraction of the masseter muscles. Elevations of mean arterial pressure and heart rate were induced by a simulated job interview. RESULTS: At baseline, the TMD patients exhibited a significantly higher electrocutaneous pain threshold. Relative to the healthy controls, the TMD patients reported increased electrocutaneous and pressure pain sensitivity after isometric contraction of the orofacial region. In addition, there were correlations between mean arterial pressure and pain sensitivity in the TMD group only. DISCUSSION: Significant increases in generalized pain sensitivity occurred in the TMD group, but not in the control group, after isometric contraction of the orofacial muscles, suggestive of a central sensitization process in TMD. Moreover, only in the TMD group there were significant associations between cardiovascular responsesand pain sensitivity, challenging previous assumptions of this relationship occurring mainly in pain-free individuals.

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• Aakhus, Eivind; Bergsholm, Per; Bigseth, Therese Torgersen; Bystad, Martin Kragnes; Coman, Alina & Folstad, Rikke Lise [Vis alle 16 forfattere av denne artikkelen] (2026). ECT og andre nevrostimulerende behandlingssmetoder. Forlaget aldring og helse. ISBN 9788284700205. 196 s. Fulltekst i vitenarkiv

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• Mohn, Christine; Haga, Egil; Nilsson, Hanne Sofie Wernø; Silviken, Anne & Mehlum, Lars (2026). Post-media campaign changes in attitudes to suicide and help-seeking in the indigenous Sami and majority Norwegian population in North-Norway. Fulltekst i vitenarkiv
• Haga, Egil; Mohn, Hanne Christine; Nilsson, Hanne Sofie Wernø & Mehlum, Lars (2025). Increasing intention to seek help for suicidal ideation and depression through a media campaign. Fulltekst i vitenarkiv
• Mohn, Hanne Christine; Haga, Egil; Nilsson, Hanne Sofie Wernø & Mehlum, Lars (2025). Who notices suicide prevention media campaigns? A study from three Norwegian regions. Fulltekst i vitenarkiv
• Nilsson, Hanne Sofie Wernø; Haga, Egil; Mohn, Hanne Christine & Lars, Mehlum (2024). Applying the Theory of Planned Behaviour in Suicide Prevention Campaign Development and Evaluation. Fulltekst i vitenarkiv
• Sellevåg, Kjersti; Kessler, Ute; Ødegaard, Ketil Joachim; Mohn, Hanne Christine; Bjørke, Jeanette & Nordenskjold, Axel [Vis alle 7 forfattere av denne artikkelen] (2024). Electroconvulsive therapy for depression: Patient- and clinician-rated short-term effects on depressive symptoms and cognition. Fulltekst i vitenarkiv
• Sellevåg, Kjersti; Kessler, Ute; Ødegaard, Ketil Joachim; Bartz-Johannessen, Christoffer; Mohn, Hanne Christine & Bjørke, Jeanette [Vis alle 7 forfattere av denne artikkelen] (2024). Electroconvulsive therapy for depression: Patient- and clinician rated short-term effects on depressive symptoms and cognition. Fulltekst i vitenarkiv
• Haga, Egil; Nilsson, Hanne Sofie Wernø; Mohn, Hanne Christine & Mehlum, Lars (2024). Changing negative attitudes towards help-seeking for suicidal ideation and depression through a media campaign. Fulltekst i vitenarkiv
• Mohn, Hanne Christine; Haga, Egil; Nilsson, Hanne Sofie Wernø & Mehlum, Lars (2024). Predictors of non-help-seeking for suicide thoughts. Fulltekst i vitenarkiv
• Mohn, Hanne Christine; Haga, Egil; Nilsson, Hanne Sofie Wernø; Pirkis, Jane & Mehlum, Lars (2024). Effectiveness of suicide prevention media campaigns in three Norwegian regions. Fulltekst i vitenarkiv
• Haga, Egil; Nilsson, Hanne Sofie Wernø; Mohn, Hanne Christine & Mehlum, Lars (2024). Effektive og trygge budskap i folkeopplysning mot selvmord. Suicidologi. ISSN 1501-6994. Fulltekst i vitenarkiv
• Sellevåg, Kjersti; Kessler, Ute; Ødegaard, Ketil Joachim; Bjørke, Jeanette; Bartz-Johannessen, Christoffer & Mohn, Hanne Christine [Vis alle 8 forfattere av denne artikkelen] (2023). Electroconvulsive therapy for depression: patient and clinician rated short term effects on depressive symptoms and cognition. Fulltekst i vitenarkiv
• Kessler, Ute; Ødegaard, Ketil Joachim; Mohn, Hanne Christine & Bartz-Johannessen, Christoffer (2023). Elektrokonvulsiv behandling for depresjon: Kortidseffekter i en uselektert pasientkohort. Fulltekst i vitenarkiv
• Mohn, Hanne Christine (2022). Sjelen i kroppen: Sang og musikk i jødisk tradisjon. I Holm, Henrik & Varkøy, Øivind (Red.), Musikk og religion: Tekster om musikk i religion og religion i musikk. Cappelen Damm Akademisk. ISSN 9788202790271. Fulltekst i vitenarkiv Vis sammendrag

  Musikk spiller en stor rolle i ulike religioner og ulike religiøse sammenhenger. Musikk og religion: Tekster om musikk i religion og religion i musikk setter søkelyset på møtepunkter mellom musikk og religion. Mennesker erfarer religion i musikken, og i religionen møter mennesket i musikalske uttrykk. Selv om musikk og religion utvilsomt gjennomtrenger hverandre, kan vi også støte på gap mellom dem: Er det mulig å overskride en musikalsk erfaring henimot det religiøse uten å måtte hoppe over dette gapet? Og finnes det en vei fra religionen direkte inn i musikken som klangfenomen? Forblir det ikke bare en religiøs fortolkning av musikk? Det finnes mye forskning på musikk og religion, men lite om hvordan de møtes. Denne antologien forsøker å gjøre noe med dette. Musikk og religion retter seg mot alle med interesse for møter mellom disse to livsfenomener. Den vil være særlig aktuell for studenter innenfor utøvende, skapende og vitenskapelige musikkutdanninger, teologi og religionsvitenskap. Boken er redigert av Henrik Holm (førsteamanuensis i pedagogikk, OsloMet, og professor i filosofi, Steinerhøyskolen), og Øivind Varkøy (professor i musikkpedagogikk og musikkvitenskap, Norges musikkhøgskole, og professor II i musikk, OsloMet).

• Mohn, Christine (2020). Lidelse, mening og livssyn - jødiske perspektiver og praksiser. Subjektive opplevelser i en kollektiv ramme. I Austad, Anne; Borge, Lisbet; Leenderts, Torborg Aalen; Stifoss-Hanssen, Hans & Thomassen, Magdalene (Red.), Lidelse mening og livssyn : teori og praksis. Fagbokforlaget. ISSN 9788245024098. s. 49–60. Fulltekst i vitenarkiv
• Mohn, Hanne Christine (2020). Subjektive opplevelser i en kollektiv ramme. I Austad, Anne; Borge, Lisbet; Leenderts, Torborg Aalen; Stifoss-Hanssen, Hans & Thomassen, Magdalene (Red.), Lidelse mening og livssyn : teori og praksis. Fagbokforlaget. ISSN 9788245024098. Fulltekst i vitenarkiv
• Torgalsbøen, Anne-Kari & Mohn, Christine (2018). Full recovery in first-episode schizophrenia: Cognitive, clinical and resilience trajectories in the Oslo Schizophrenia Recovery study across 6 years. Fulltekst i vitenarkiv
• Mohn, Christine (2016). Kognitive utfall ved depresjon. Best Practice Psykiatri/Nevrologi. September, s. 43–45. Fulltekst i vitenarkiv
• Mohn, Christine & Rund, Bjørn Rishovd (2014). Neurocognitive improvement in depression patients after ECT. Fulltekst i vitenarkiv
• Mohn, Christine (2013). Kardiovaskulær aktivering og trykksmertesensitivitet. Best Practice Smerte. 2(7), s. 15–17. Fulltekst i vitenarkiv
• Lystad, June; Falkum, Erik; Bull, Helen; Mohn, Christine; Evensen, Stig & Rund, Bjørn Rishovd [Vis alle 7 forfattere av denne artikkelen] (2013). The MATRICS Consensus Cognitive Battery (MCCB) in Norway:Functional Correlates. Fulltekst i vitenarkiv
• Mohn, Christine & Rund, Bjørn Rishovd (2012). The MATRICS Consensus Cognitive Battery in older Norwegians. Fulltekst i vitenarkiv
• Rund, Bjørn Rishovd; Mohn, Christine & Sundet, Kjetil Søren (2010). MATRICS på norsk. Tidsskrift for Norsk psykologforening (Psykologtidsskriftet). ISSN 0332-6470. 47, s. 160–160. Fulltekst i vitenarkiv
• Mohn, Christine (2007). "Jeg vil jo bare hjelpe deg!". A-magasinet : uketillegg til Aftenposten. ISSN 0807-5654. Fulltekst i vitenarkiv
• Mohn, Christine (2007). Hvorfor gjør det vondt? A-magasinet : uketillegg til Aftenposten. ISSN 0807-5654. Fulltekst i vitenarkiv
• Mohn, Christine (2007). En salig rus. A-magasinet : uketillegg til Aftenposten. ISSN 0807-5654. Fulltekst i vitenarkiv
• Mohn, Christine (2007). Musikk, læring og Mozart-effekten. Pedagogisk profil. ISSN 0805-5610. 14(4). Fulltekst i vitenarkiv
• Mohn, Christine; Vassend, Olav & Knardahl, Stein (2002). Effects of distraction on experimental pain in temporomandibular disorders (TMD) and healthy controls. Fulltekst i vitenarkiv
• Mohn, Hanne Christine; Vassend, Olav & Knardahl, Stein (2002). Personality traits and psychological distress in temporomandibular disorders (TMD). Fulltekst i vitenarkiv

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