Ida Kristin Bos-Haugen

• Klingenberg, Lovisa; Bos-Haugen, Ida Kristin; Hammer, Hilde Berner; Maugesten, Øystein Gunnar; Mathiessen, Alexander & Gløersen, Marthe (2026). JOINT-SPECIFIC ASSOCIATIONS BETWEEN ULTRASOUND AND MRI-DETECTED SYNOVITIS AND RADIOGRAPHIC PROGRESSION IN HAND OSTEOARTHRITIS: A COMPARISON OF CMC1 AND INTERPHALANGEAL JOINTS. Osteoarthritis and Cartilage. ISSN 1063-4584. 34, s. 256–256. doi: 10.1016/j.joca.2026.01.351. Fulltekst i vitenarkiv Vis sammendrag

  Purpose (the aim of the study): Synovitis is a well-established feature associated with structural progression in hand osteoarthritis (OA). In light of the new 2023 European Alliance of Associations of Rheumatology (EULAR) classification criteria for hand OA, which distinguish first carpometacarpal (CMC1) and interphalangeal OA as separate phenotypes, it remains unknown whether synovitis has similar prognostic value across these joint groups. We therefore aimed to determine whether baseline synovitis by ultrasound or magnetic resonance imaging (MRI) predicted radiographic progression over 3.5 years, looking at the CMC1 and the interphalangeal joints separately.

• Mulrooney, Elisabeth; Gløersen, Marthe; Hauge, Jostein Wågen; Neogi, Tuhina; Pettersen, Pernille Steen & Bos-Haugen, Ida Kristin (2026). REPRODUCTIVE LIFESPAN AND PAIN: MEASURES OF SENSITIZATION DIVERGE FROM THE PAIN EXPERIENCE IN HAND OSTEOARTHRITIS. Osteoarthritis and Cartilage. ISSN 1063-4584. 34. doi: 10.1016/j.joca.2026.01.531. Fulltekst i vitenarkiv
• Klingenberg, Lovisa; Haugen, Ida K; Hammer, Hilde Berner; Maugesten, Øystein Gunnar; Mathiessen, Alexander & Gløersen, Marthe (2026). Associations between synovitis and radiographic osteoarthritis progression in the first carpometacarpal and interphalangeal joints: results from the Nor-Hand study. RMD Open. 12(3), s. 007074–007074. doi: 10.1136/rmdopen-2026-007074. Fulltekst i vitenarkiv Vis sammendrag

  Objectives To determine whether baseline synovitis detected by ultrasound or MRI predicts radiographic osteoarthritis (OA) progression in the first carpometacarpal (CMC1) and interphalangeal joints. Methods We included 201 participants with hand OA from the Nor-Hand cohort. The CMC1 and interphalangeal joints were examined by ultrasound (both hands) and MRI (dominant hand) at baseline. Grey-scale synovitis, power Doppler activity and MRI-defined synovitis were scored on 0–3 scales. Bilateral hand radiographs at baseline and follow-up were scored by the same reader. We examined whether synovitis at baseline predicted radiographic progression in the same joint defined as ≥1 increase in Kellgren-Lawrence grade, osteophytes or joint space narrowing or incident erosions. CMC1 and interphalangeal joints were analysed separately using logistic regression with generalised estimating equations, adjusted for age, sex, body mass index and follow-up time. Results Radiographic Kellgren-Lawrence progression occurred in 14.7% of CMC1 joints and 10.2% of interphalangeal joints. Baseline grey-scale synovitis was associated with radiographic progression in the CMC1 and interphalangeal joints with the strongest observed association between grade 3 synovitis and Kellgren-Lawrence progression (OR (95% CI) of 9.3 (2.2 to 39.6) and 23.4 (10.4 to 52.9), respectively). Similar relationships were found for power Doppler activity and MRI-defined synovitis. Conclusions Baseline synovitis detected by ultrasound and MRI was associated with radiographic progression in both CMC1 and interphalangeal joints, supporting inflammation as a relevant prognostic feature across hand OA phenotypes. Trial registration number NCT03083548 .

• Bayramoglu, Neslihan; Englund, Martin; Bos-Haugen, Ida Kristin; Ishijima, Muneaki & Saarakkala, Simo (2026). Beyond the algorithms: Challenges in predicting knee osteoarthritis pain from a machine learning point of view. Osteoarthritis Imaging. 6(2), s. 100381–100381. doi: 10.1016/j.ostima.2025.100381. Fulltekst i vitenarkiv
• Driban, Jeffrey B.; Rokoff, Lisa B.; Lu, Bing; McAlindon, Timothy E.; Eaton, Charles B. & Roberts, Mary B. [Vis alle 15 forfattere av denne artikkelen] (2026). Per‐ and Polyfluoroalkyl Substances and Knee Osteoarthritis: Data From the Osteoarthritis Initiative. Arthritis & Rheumatology. ISSN 2326-5191. doi: 10.1002/art.70154. Fulltekst i vitenarkiv Vis sammendrag

  Objective To examine whether concentrations of specific per‐ and polyfluoroalkyl substances (PFAS) and a mixture of PFAS relate to incident knee osteoarthritis (KOA) and knee pain progression. Methods Among a case‐cohort sample from the OA Initiative (n = 1,878), we examined associations of serum concentrations of eight PFAS with odds of developing over the subsequent 48 months (1) symptomatic KOA and (2) a clinically meaningful change in the Western Ontario and McMaster Universities OA Index knee pain score. We used weighted logistic regression to assess single PFAS (continuous and quartiles) and quantile g‐computation to assess the PFAS mixture in relation to our outcomes, accounting for sociodemographics. Results Fifty‐eight percent of participants were female with a mean age of 62 years and body mass index of 28.6 kg/m 2 . Participants with higher perfluorooctanoic acid (continuous) had greater odds of incident symptomatic KOA (odds ratio [OR] per interquartile range [IQR] 1.12, 95% confidence interval [CI] 1.04–1.21). Participants in the highest quartiles of perfluorononanoic acid (PFNA) had greater odds of incident symptomatic KOA [OR for the third quartile 1.63, 95% CI 1.29–2.07; fourth quartile 1.55, 95% CI 1.19–2.01). Perfluorooctanoic acid may have a nonlinear relationship with the greatest chance of incident symptomatic KOA with serum concentrations between 5.19 and 6.88 ng/mL (OR 1.55, 95% CI 1.21–1.97). Participants with greater perfluorooctanoic acid and PFNA (continuous) had greater odds of knee pain progression (OR per IQR: perfluorooctanoic acid 1.10, 95% CI 1.03–1.18; PFNA 1.06, 95% CI 1.01–1.11). Mixture models showed perfluorooctanoic acid and PFNA were among the PFAS with the strongest positive weights for both outcomes. Conclusion In a large cohort at risk for KOA, higher perfluorooctanoic acid and PFNA serum concentrations may be associated with a greater likelihood of symptomatic KOA incidence and knee pain progression.

• Wolski, M.; Podsiadlo, P.; Turkiewicz, A.; Ishijima, M.; Saarakkala, S. & Englund, Martin Trøan [Vis alle 7 forfattere av denne artikkelen] (2026). Associations of trabecular bone texture with anatomical phases of osteoarthritis evolution and its progression in finger joints: Results from the Nor-Hand study. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2026.07.006. Fulltekst i vitenarkiv
• Girdwood, Michael; Liew, Jean W.; Bos-Haugen, Ida Kristin; Pazzinatto, Marcella F.; Bruder, Andrea M. & Dalbeth, Nicola [Vis alle 8 forfattere av denne artikkelen] (2026). Gender Equity in Rheumatology Research: Global Analysis of Authors. Arthritis & Rheumatology. ISSN 2326-5191. doi: 10.1002/art.70210. Fulltekst i vitenarkiv
• Nguyen, H. Chien; Bax, Eva; Custers, Roel J.H.; Egmond, Nienke van; Kuiper, Ruurd J.A. & Arbabi, Vahid [Vis alle 18 forfattere av denne artikkelen] (2026). Progression of bone and joint space deformity in patients with mild knee osteoarthritis: Data from the IMI-APPROACH cohort. Osteoarthritis and Cartilage Open. 8(2). doi: 10.1016/j.ocarto.2026.100762. Fulltekst i vitenarkiv
• Janssen, Yannick; Nguyen, H. Chien; Custers, Roel J.H.; Egmond, Nienke van; Kruyt, Moyo C. & Sakkers, Ralph J.B. [Vis alle 14 forfattere av denne artikkelen] (2026). Uncovering the Impact of Center of Rotation of Angulation Location on High Tibial Osteotomy in Knee Osteoarthritis: A Potential Pathway for Improved Outcomes. Cartilage. ISSN 1947-6035. doi: 10.1177/19476035261420279. Fulltekst i vitenarkiv
• Bordvik, Daniel Huseby; Gløersen, Marthe; Mulrooney, Elisabeth; Pettersen, Pernille Steen; Sundbakk, Lene Maria & Neogi, Tuhina [Vis alle 8 forfattere av denne artikkelen] (2026). The severity of fatigue and its interplay with biological and psychological factors in people with hand osteoarthritis – Results from the Nor-Hand study. Osteoarthritis and Cartilage Open. 8(1). doi: 10.1016/j.ocarto.2026.100747. Fulltekst i vitenarkiv
• Bordvik, Daniel Huseby; Mulrooney, Elisabeth; Pettersen, Pernille Steen; Gløersen, Marthe; Sundbakk, Lene Maria & Neogi, Tuhina [Vis alle 8 forfattere av denne artikkelen] (2026). The stability of pain phenotypes in people with hand osteoarthritis – results from the NOR-HAND study. Osteoarthritis and Cartilage Open. 8(1). doi: 10.1016/j.ocarto.2026.100745. Fulltekst i vitenarkiv
• Jansen, M. P.; Mastbergen, S. C.; Wirth, W.; Roemer, F. W.; Bacardit, J. & Bay-Jensen, A. C. [Vis alle 12 forfattere av denne artikkelen] (2025). How are patient-reported pain outcomes associated with biomarker and structural pathology subtypes in knee osteoarthritis? An explorative evaluation in the IMI-APPROACH cohort. Osteoarthritis and Cartilage Open. 8(1). doi: 10.1016/j.ocarto.2025.100726. Fulltekst i vitenarkiv
• Fuggle, Nicholas R.; Chapurlat, Roland; Laslop, Andrea; Al-Daghri, Nasser; Alokail, Majed & Thiyagarajan, Jotheeswaran Amuthavalli [Vis alle 38 forfattere av denne artikkelen] (2025). Novel approaches to the stratified management of knee osteoarthritis. Nature Reviews Rheumatology. ISSN 1759-4790. 21(11), s. 695–695. doi: 10.1038/s41584-025-01305-x. Fulltekst i vitenarkiv
• Wallace, Ian J.; Felson, David T.; Kraus, Virginia B.; Neogi, Tuhina; Haugen, Ida K. & Huebner, Janet L. [Vis alle 14 forfattere av denne artikkelen] (2025). Dampened inflammation and reduced risk of osteoarthritis among non-industrialized societies. Osteoarthritis and Cartilage. ISSN 1063-4584. 34(1), s. 27–27. doi: 10.1016/j.joca.2025.09.014. Fulltekst i vitenarkiv
• Roemer, Frank W.; Jansen, Mylène; Maschek, Susanne; Mastbergen, Simon; Wisser, Anna & Weinans, Harrie H. [Vis alle 13 forfattere av denne artikkelen] (2025). Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? – Data from the FNIH and IMI-APPROACH cohorts. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2025.10.003. Fulltekst i vitenarkiv
• Bax, Eva A.; Kerkhof, Joost A.J.; Egmond, Nienke van; Kuiper, Ruurd J.A.; Rayegan, Hassan & Kloppenburg, Margreet [Vis alle 16 forfattere av denne artikkelen] (2025). The Impact of varus and valgus alignment on knee cartilage quality assessed by magnetic resonance imaging: insights from the IMI-APPROACH cohort. Knee (Oxford). ISSN 0968-0160. 57, s. 487–487. doi: 10.1016/j.knee.2025.10.005. Fulltekst i vitenarkiv
• Bax, Eva A.; Custers, Roel J.H.; Egmond, Nienke van; Kruyt, Moyo C.; Rayegan, Hassan & Kloppenburg, Margreet [Vis alle 13 forfattere av denne artikkelen] (2025). Unicompartmental versus bicompartmental joint space width measures: Which reflect whole joint structural damage better? Data from IMI-APPROACH. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2025.11.011. Fulltekst i vitenarkiv
• Collins, Kelsey H.; Haugen, Ida K.; Neogi, Tuhina & Guilak, Farshid (2025). Osteoarthritis as a systemic disease. Nature Reviews Rheumatology. ISSN 1759-4790. doi: 10.1038/s41584-025-01332-8. Fulltekst i vitenarkiv
• Salzlechner, C.; Wirth, W.; Mastbergen, S.C.; Kloppenburg, M.; Blanco, F.J. & Haugen, I.K. [Vis alle 8 forfattere av denne artikkelen] (2025). Does spontaneous cartilage thickening occur in osteoarthritic knees? Data from IMI-APPROACH and the OAI. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2025.12.002. Fulltekst i vitenarkiv
• Driban, Jeffrey B.; Rokoff, Lisa B.; Lu, Bing; McAlindon, Timothy E.; Eaton, Charles B. & Roberts, Mary B. [Vis alle 15 forfattere av denne artikkelen] (2025). Per‐ and polyfluoroalkyl substances and hand osteoarthritis: data from the Osteoarthritis Initiative. Arthritis & Rheumatology. ISSN 2326-5191. 77(12). doi: 10.1002/art.70026. Fulltekst i vitenarkiv Vis sammendrag

  Objective To explore whether biological levels of specific per‐ and polyfluoroalkyl substances (PFAS) and a mixture of PFAS – reflecting the overall effect and accounting for correlations among each PFAS – relate to incident hand osteoarthritis (HOA) and progression. Methods Among a case‐cohort sample from the Osteoarthritis Initiative (n=1,878), we examined associations of 8 PFAS in serum with odds of developing over the subsequent 4 years (1) symptomatic HOA and (2) an increased number of joints with radiographic osteoarthritis (Kellgren‐Lawrence≥2; yes/no). We used weighted logistic regression to assess single PFAS (continuous and quartiles) and quantile g‐computation to assess the PFAS‐mixture in relation to our primary outcomes. Results Participants were primarily female (58%) and on average 62 years of age and overweight (mean BMI=28.6 kg/m 2 ). Participants with higher perfluorodecanoic acid (PFDA) and perfluorononanoic acid (PFNA; continuous variables) had greater odds of incident symptomatic HOA [OR (95%CI) per interquartile‐range increment: PFDA 1.12 (1.05‐1.20); PFNA 1.07 (1.00‐1.13)], but associations were not monotonic when these PFAS were represented in quartiles. Participants with higher perfluorohexane sulfonoic acid (PFHxS) had lower odds of incident HOA [e.g., OR (95%CI): 0.94 (0.88‐1.00) per interquartile‐range increment]. We observed no other consistent associations between PFAS and either outcome. Conclusion We observed possible associations of PFDA and PFNA serum concentrations with symptomatic HOA incidence, but we otherwise found no consistent evidence that greater PFAS concentrations relate to a greater chance of developing HOA incidence or progression.

• Drude, Benedict; Maugesten, Øystein Gunnar; Werner, Stephanie G.; Klotsche, Jens; Burmester, Gerd-Rüdiger & Krönke, Gerhard [Vis alle 10 forfattere av denne artikkelen] (2025). Differential diagnosis between psoriatic arthritis and hand osteoarthritis using indocyanine green-based fluorescence optical imaging. Frontiers in Medicine. 12. doi: 10.3389/fmed.2025.1581265. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Fluorescence optical imaging (FOI) visualizes enhanced microcirculation in the hands as a marker for inflammation. The correct diagnosis of psoriatic arthritis (PsA) and erosive hand osteoarthritis (EHOA) can be challenging. The aim of this study was to differentiate active PsA from EHOA using FOI. Methods An atlas with FOI images of different grades of enhancement (FOIAS 0–3) and typical morphologic patterns (‘Streaky signals’, ‘Green/Blue Nail sign’, ‘Werner sign’, and ‘Bishop’s crozier sign’) for PsA and hand EHOA was created. Twenty FOI sequences of patients with PsA and EHOA were randomly mixed and scored by two blinded readers. All images were scored twice by one of the two readers. Inter- and intra-reader reliability for joint enhancement, morphologic patterns and diagnosis (PsA vs. EHOA) was calculated. Subsequently, one reader blinded to the diagnosis scored the remaining PsA ( n  = 54) and EHOA ( n  = 47) images using the same atlas. Results Inter-reader reliability on joint enhancement was overall substantial ( κ  = 0.74), with substantial to almost perfect intra-reader reliability ( κ  = 0.88). Inter-reader reliability on all morphological patterns was fair ( κ  = 0.36) and substantial ( κ  = 0.68) in the intra-reader exercise with variation between the different patterns. Inter- ( κ  = 0.3) and intra-reader reliability ( κ  = 0.4) on diagnosis was fair. In analyses of all 101 cases (47 EHOA, 54 PsA), persons with EHOA presented significantly higher mean FOI sum scores in the PIP (38.98 vs. 20.00) and DIP joints (16.45 vs. 8.40) compared to the PsA patients. Regarding morphology, the ‘Werner sign’ was significantly more often detected in PsA than in EHOA (55.6% vs. 21.3%; p  < 0.01). Conclusion Joint enhancement in FOI can be reliably assessed using a predefined scoring method. The stronger enhancement in PIP and DIP joints for EHOA cases and the occurrence of ‘Werner sign’ in PsA cases may facilitate the differential diagnosis between the two diagnoses.

• Stumper, Nele; Berger, Jörn; Klotsche, Jens; Gedat, Egbert; Hoff, Paula & Schmittat, Gabriela [Vis alle 11 forfattere av denne artikkelen] (2025). To optimise the diagnostic process of rheumatic diseases affecting the hands using fluorescence optical imaging (FOI). RMD Open. 11(3), s. 005372–005372. doi: 10.1136/rmdopen-2024-005372. Fulltekst i vitenarkiv Vis sammendrag

  Background Accurate and rapid diagnosis of rheumatic diseases is essential for further treatment decision. Different rheumatic diseases present characteristic patterns (image features) in fluorescence optical imaging (FOI). We developed an atlas of FOI image features and tested its ability to differentiate various rheumatic diseases. Methods FOI images from patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), connective tissue diseases (CTD) and osteoarthritis (OA) were analysed by two readers blinded for diagnosis and calibrated against each other, using the prima vista mode (PVM) and an automated 5-phase model. Twenty-six different reoccurring typical signal enhancement patterns (features) indicating inflamed joints, nail or skin were defined and all FOI images were scored accordingly. The feature frequency in each patient cohort and phase (PVM, 5-phase) was counted. Contingency tables were created with categorical variable counts and diagnosis using common formulae. Findings Four hundred thirty-eight patients with RA (n=117), PsA (n=110), CTD (n=121) and OA (n=90) were included. Once the data had been categorised, a two-step diagnostic pathway was developed: in the first step, OA was best distinguished from the other diseases with high specificity by five patterns (specificity >0.9, diagnostic OR between 2.34 and 8.24). In a second step, the remaining autoimmune diseases were differentiated from each other by a certain number of features (five for RA, 12 for PsA and four for CTD). Interpretation This was the first study to show that feature analysis in FOI helps to differentiate typical rheumatic diseases from each other, potentially simplifying and speeding up the diagnostic process. Therefore, FOI could be considered an additional component of a wider range of imaging techniques used in rheumatology.

• Bentvelzen, Mieke L. M.; Welsing, Paco M.J.; Moingeon, Philippe; Mastbergen, Simon C.; Kloppenburg, Margreet & Blanco, Francisco J. [Vis alle 11 forfattere av denne artikkelen] (2025). Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort. PLOS ONE. 20(6), s. 0325819–0325819. doi: 10.1371/journal.pone.0325819. Fulltekst i vitenarkiv Vis sammendrag

  Objective Knee osteoarthritis (OA) is a heterogeneous disease with different endotypes and phenotypes, resulting in patients’ varying clinical and structural progression. Several genomic markers have been associated with knee OA presence . This study aimed to find new associations of these genetic markers with knee OA progression and to investigate the risk of knee OA progression using a polygenic risk score (PRS). Methods Data from knee OA patients (n = 297) from the IMI-APPROACH cohort with detailed measurements on disease progression were used. Knee OA progression definitions were based on the decrease in minimum joint space width in mm (minJSW; primary outcome), increase in pain on the Knee injury and Osteoarthritis Outcome Score (KOOS), and presence of radiographic OA (based on the Kellgren-Lawrence score) over 24 months. 30 previously reported single nucleotide polymorphisms (SNPs) associated with presence of OA irrespective of affected joints or knee OA specifically were investigated. We performed a SNP based genome-wide association analysis using the disease progression definitions. Furthermore, a PRS was created using the 30 presence SNPs to predict knee OA progression . Results Existing genetic markers for knee OA presence were not found to be associated with knee OA progression . The PRS of the SNPs for knee OA presence did also not show significant predictive value for knee OA progression. Unexpectedly, nineteen different variants were associated significantly ( P  < 5 × 10 −8 ) with minJSW decrease. Ten SNPs are located near protein coding genes PLCL2 , CDYL2 , and NTNG1 , and several SNPs are located in or near long non-coding RNAs (lncRNA). Conclusions The 30 OA risk SNPs individually and combined in a PRS are not associated with progression of knee OA in the IMI-APPROACH cohort. 19 different SNPs were associated with minJSW decrease. We demonstrated how to employ multiple bioinformatics tools to, despite a limited dataset, still prioritise potential biomarkers for associations to knee OA progression.

• Bos-Haugen, Ida Kristin; Gløersen, Marthe; Mulrooney, Elisabeth & Mathiessen, Alexander (2025). Inflammation as a Treatment Target in Hand Osteoarthritis: A Review of Previous Studies and Future Perspectives. Journal of Rheumatology. ISSN 0315-162X. s. 0206–0206. doi: 10.3899/jrheum.2025-0206. Fulltekst i vitenarkiv Vis sammendrag

  Historically, osteoarthritis (OA) was considered a noninflammatory joint disease, distinct from systemic inflammatory diseases such as rheumatoid arthritis and psoriatic arthritis. However, observational studies on hand OA have shown that synovitis is common and is associated with both pain and disease progression. Hence, targeting synovitis in hand OA could provide clinical benefits in terms of symptom relief and disease modification. Conflicting results have been found in several previous studies that have tested the efficacy of various antiinflammatory treatments, including oral and topical nonsteroidal antiinflammatory drugs (NSAIDs), oral and intraarticular corticosteroids, colchicine, and synthetic and biologic disease-modifying antirheumatic drugs (DMARDs). To date, prednisolone and methotrexate have shown the most promising results. Several ongoing studies, especially those investigating intraarticular antiinflammatory therapies, are expected to provide valuable insights for clinical practice.

• Jansen, Mylène P.; Turmezei, Tom D.; Dattani, Kishan; Kessler, Dimitri A.; Mastbergen, Simon C. & Kloppenburg, Margreet [Vis alle 13 forfattere av denne artikkelen] (2025). Cartilage thickness distribution and its dependence on demographic, radiographic, and MRI structural pathology in knee osteoarthritis—data from the IMI-APPROACH cohort. Skeletal Radiology. ISSN 0364-2348. doi: 10.1007/s00256-025-04907-4. Fulltekst i vitenarkiv
• King, L.K.; Liew, J.W.; Mahmoudian, A.; Wang, Q.; Jansen, N.E.J. & Stanaitis, I. [Vis alle 26 forfattere av denne artikkelen] (2025). Multi-centre modified Delphi exercise to identify candidate items for classifying early-stage symptomatic knee osteoarthritis. Osteoarthritis and Cartilage. ISSN 1063-4584. 33(1), s. 155–165. doi: 10.1016/j.joca.2024.10.016. Fulltekst i vitenarkiv Vis sammendrag

  Objective: To generate a list of candidate items potentially useful for discriminating individuals with Earlystage Symptomatic Knee Osteoarthritis (EsSKOA) from those with other conditions and from established osteoarthritis (OA), and to reduce this list based on expert consensus. Design: We conducted a three-round online international modified Delphi exercise with OA clinicians and researchers (“OA experts”). In Round 1, participants reviewed 84 candidate items and nominated additional item(s) potentially useful for EsSKOA classification; those nominated by ≥3 participants were added. In Round 2, participants rated perceived usefulness of 108 items (1 [not at all useful] to 9 [extremely useful]). In Round 3, participants could revise their ratings after reviewing Round 2 group median and quartiles. Following Round 3, we retained items with a median usefulness score > 5 and ≥33.3% of participants categorised the item as useful (7 to 9), overall and in subgroup analysis by clinician field. Results: There were 128 participants in Round 1 and 113 (88%) completed all rounds. We retained 77 items that spanned multiple domains (demographics, symptoms, physical exam, performance-based measures, imaging, laboratory investigations, and gross inspection/arthroscopy). Highly rated items included (median usefulness score): prior knee joint injury (8), diagnosis of OA in a different joint (7), and activity-related knee pain (7). The interquartile range was most often 3. Conclusion: We identified 77 items that OA experts consider potentially useful for EsSKOA classification. The results highlight experts’ uncertainty around item usefulness. Next, candidate items will be further assessed and reduced using data-driven and multicriteria decision analysis methods.

• Bordvik, Daniel Huseby; Pettersen, Pernille Steen; Gløersen, Marthe; Mulrooney, Elisabeth; Neogi, Tuhina & Kjeken, Ingvild [Vis alle 7 forfattere av denne artikkelen] (2025). The associations between sleep problems and pain outcomes in people with hand osteoarthritis – Data from the Nor-hand study. Osteoarthritis and Cartilage Open. 7(1). doi: 10.1016/j.ocarto.2025.100579. Fulltekst i vitenarkiv
• Høegh, Dekkerhus Caroline; Mathiessen, Alexander; Fjellstad, Caroline Mehl; Christensen, Barbara Therese Slatkovsky; Hammer, Hilde Berner & Bos-Haugen, Ida Kristin (2025). The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study. Osteoarthritis and Cartilage Open. 7(3). doi: 10.1016/j.ocarto.2025.100640. Fulltekst i vitenarkiv
• Hawker, Gillian A.; King, Lauren K.; Liew, Jean W.; Wang, Qiuke; Mahmoudian, Armaghan & Jansen, Nuria E.J. [Vis alle 25 forfattere av denne artikkelen] (2025). OARSI initiative to develop classification criteria for early-stage symptomatic knee OA (EsSKOA): What conditions should be considered in the differential diagnosis of EsSKOA? Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2025.05.005. Fulltekst i vitenarkiv
• Polster, Annikka Virginia; Olsen, Unni; Asphaug, Lars; Bergsmark, Kjetil; Christensen, Barbara Therese Slatkovsky & Bos-Haugen, Ida Kristin [Vis alle 13 forfattere av denne artikkelen] (2025). Occupational therapist-led versus rheumatologist-led care in people with hand osteoarthritis in Norway: an open-label, multicentre, randomised controlled, non-inferiority trial. The Lancet Rheumatology. doi: 10.1016/S2665-9913(25)00040-2. Fulltekst i vitenarkiv
• Vanhaverbeke, T.; Miller, G.; Ukonu, N.C.; Wittoek, R.; Bos-Haugen, Ida Kristin & Felson, D. (2025). Presence of erosions is not a risk factor for the development of knee OA in a hand OA population: Results from the Framingham OA study. Osteoarthritis and Cartilage Open. 7(2). doi: 10.1016/j.ocarto.2025.100591. Fulltekst i vitenarkiv Vis sammendrag

  Objective: This study aimed to investigate whether there is a difference in risk of knee OA between individuals with erosive hand osteoarthritis (OA) compared to non-erosive hand OA, and to identify other risk factors for knee OA presence and development in hand OA patients. Methods: Subjects were selected from the Framingham OA study's Offspring and Community cohorts. Bilateral knee and hand radiographs were scored. Generalized linear models compared knee OA prevalence and incidence rates among hand OA-free, non-erosive and erosive hand OA. Multivariable logistic regression identified risk factors for symptomatic knee OA (presence of hand OA, anatomical location, erosions, number of affected finger joints, radiographic grade changes), adjusted for age, sex and BMI. Results: In total, 2367 participants were studied. Hand classification (hand OA-free, non-erosive and erosive hand OA) significantly impacted the prevalence of knee OA (P < 0.0001). Prevalence rates at baseline were 6.3 %, 17.9 % and 26.8 % for radiographic knee OA and 2.9 %, 9.7 % and 12.7 % for symptomatic knee OA for hand OA-free, non-erosive and erosive hand OA respectively. Post hoc analysis indicated differences were primarily between hand OA-free and hand OA groups (p < 0.001), with no significant differences between erosive and non-erosive hand OA (p ¼ 0.7 and p ¼ 0.8). Overall, hand OA was identified as a risk factor for knee OA development. Presence of erosions did not increase risk, but the number of affected finger joints and changes in KellgrenLawrence grade did. Conclusion: Hand OA is associated with knee OA presence and incidence with no difference in the risk of knee OA between those with non-erosive vs erosive hand OA.

• Harlianto, Netanja I.; Jong, Pim A. de; Foppen, Wouter; Bennink, Edwin; Bunk, Stijn & Mastbergen, Simon C. [Vis alle 15 forfattere av denne artikkelen] (2025). Aortic, musculoskeletal and organ characteristics on computed tomography in knee osteoarthritis – an explorative study in the IMI-APPROACH cohort. Rheumatology International. ISSN 0172-8172. 45(3). doi: 10.1007/s00296-025-05817-3. Fulltekst i vitenarkiv Vis sammendrag

  The systemic associations with knee osteoarthritis (KOA) are incompletely understood. This study explores aortic disease, musculoskeletal and organ findings in patients with KOA in relation to their symptoms or radiographic abnormalities. Full body computed tomography (CT) scans of 255 IMI-APPROACH participants were investigated using an automated analysis of multislice CT (Voronoi Health Analytics) that extracts aortic size and calcifications, and volumes and densities of bones, muscles, fat compartments and thoracic and abdominal organs. The CT measurements were primarily related to KOA as measured with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual scores and automated knee radiograph analysis of osteophytes, bone sclerosis and joint space width. The median age was 67 years, body mass index (BMI) 26.8 kg/m2 and 78% were female. About half had Kellgren-Lawrence grade ≥ 2. Larger knee osteophyte area was associated with a larger aortic volume (RSpearman=0.21,P = 0.001), which can be due to elongation or dilatation. We observed an association between more symptoms and increased psoas (RSpearman=-0.23,P < 0.001) and lower leg (RSpearman=-0.23,P < 0.001) muscle density, suggesting less microscopic muscle fat. Symptomatic KOA was associated with substantially lower lung volume (771 ml difference between 50% worst and 50% best WOMAC), but not with visible lung disease. Lung volume and density were significantly associated with the physical functioning WOMAC component. These associations remained significant after adjustment for age, sex and BMI. KOA is associated with significant systemic changes, including altered aortic and organ volumes. These correlations suggest that KOA’s impact may extend beyond the joints. Future research should explore the causal relationships and therapeutic implications associations.

• Bordvik, Daniel Huseby; Prior, Yeliz; Bamford, Rachael; Berenbaum, Francis; Björk, Mathilda & Blanck, Thale Beate [Vis alle 19 forfattere av denne artikkelen] (2025). Development of quality indicators for hand osteoarthritis care – Results from an European consensus study. Osteoarthritis and Cartilage Open. 7(1). doi: 10.1016/j.ocarto.2025.100578. Fulltekst i vitenarkiv Vis sammendrag

  Background: People with hand osteoarthritis (OA) often have poor access to recommended treatments. To enhance care quality, quality indicators (QIs) based on clinical recommendations are essential. Current QI sets, like the Osteoarthritis Quality Indicator Questionnaire (OA-QI v.2), primarily address hip- and knee OA, and not hand OA. Objectives: To adapt the OA-QI v.2 for assessing patient-reported quality of hand OA care. Design: We used the OA-QI v.2. set as a starting point and adapted it to reflect hand OA care. A literature search was performed to identify potential QIs for hand OA following the Rand/UCLA Appropriateness method. A European expert panel, comprising researchers, clinicians, and patient research partners, participated in online meetings to discuss adaptation and suggest new QIs based on treatment recommendations for hand OA, and anonymously rated each suggested QI regarding its importance, validity, usefulness, and feasibility. Consensus was defined by predefined rating cut-off scores. The adapted questionnaire was translated from English into Norwegian. Cognitive debriefing interviews with Norwegian and UK hand OA patients were conducted to ensure clarity. Results: Our initial literature search provided 1670 articles, with none describing relevant QIs. After three voting rounds, sixteen QI items reached consensus, reflecting current hand OA care standards. Items were generally well understood, requiring only minor clarity amendments after patient interviews (N ¼ 28).

• Kjeken, Ingvild; Bordvik, Daniel Huseby; Østerås, Nina; Bos-Haugen, Ida Kristin; Fjeldstad, Kristine Aasness & Skaalvik, Ingrid [Vis alle 10 forfattere av denne artikkelen] (2025). Efficacy and safety of non-pharmacological, pharmacological and surgical treatments for hand osteoarthritis in 2024: a systematic review. RMD Open. 11(1). doi: 10.1136/rmdopen-2024-004963. Fulltekst i vitenarkiv
• King, Lauren K.; Mahmoudian, Armaghan; Liew, Jean W.; Wang, Qiuke; Stanaitis, Ian & Schiphof, Dieuwke [Vis alle 16 forfattere av denne artikkelen] (2025). Elucidating the initial symptoms and experiences of knee osteoarthritis: An international patient survey. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2025.05.008. Fulltekst i vitenarkiv
• Yau, Michelle S.; Okoro, Paul C.; Bos-Haugen, Ida Kristin; Lynch, John A.; Nevitt, Michael C. & Lewis, Cora E. [Vis alle 8 forfattere av denne artikkelen] (2024). Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST). Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2023.11.024. Fulltekst i vitenarkiv
• Hannani, Monica T.; Thudium, Christian S.; Gellhorn, Alfred C.; Larkin, Jonathan; Karsdal, Morten A. & Lisowska-Petersen, Zofia [Vis alle 20 forfattere av denne artikkelen] (2024). Longitudinal stability of molecular endotypes of knee osteoarthritis patients. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2024.11.002. Fulltekst i vitenarkiv
• Jansen, M.P.; Hodgins, D.; Mastbergen, S.C.; Kloppenburg, M.; Blanco, F.J. & Bos-Haugen, Ida Kristin [Vis alle 10 forfattere av denne artikkelen] (2024). Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis? Data from the IMI-APPROACH cohort. Skeletal Radiology. ISSN 0364-2348. doi: 10.1007/s00256-024-04666-8. Fulltekst i vitenarkiv
• McAlindon, Timothy E.; Hunnicutt, Jennifer L.; Roberts, Mary B.; Bos-Haugen, Ida Kristin; Schaefer, Lena F. & Driban, Jeffrey B. [Vis alle 14 forfattere av denne artikkelen] (2024). Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2023.10.011. Fulltekst i vitenarkiv
• Roemer, Frank W.; Jansen, Mylène P.; Maschek, Susanne; Mastbergen, Simon C.; Marijnissen, Anne-Karien & Wisser, Anna [Vis alle 16 forfattere av denne artikkelen] (2024). Fluctuation of Bone Marrow Lesions and Inflammatory MRI Markers over 2 Years and Concurrent Associations with Quantitative Cartilage Loss. Cartilage. ISSN 1947-6035. doi: 10.1177/19476035241287694. Fulltekst i vitenarkiv
• King, L.K.; Mahmoudian, A.; Waugh, E.J.; Stanaitis, I.; Gomes, M. & Hung, V. [Vis alle 17 forfattere av denne artikkelen] (2024). “You don't put it down to arthritis”: A qualitative study of the first symptoms recalled by individuals with knee osteoarthritis. Osteoarthritis and Cartilage Open. 6(1). doi: 10.1016/j.ocarto.2023.100428. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin; Felson, David T.; Abhishek, Abhishek; Berenbaum, Francis; Bierma-Zeinstra, Sita & Dziedzic, Krysia S. [Vis alle 31 forfattere av denne artikkelen] (2024). 2023 EULAR classification criteria for hand osteoarthritis. Annals of the Rheumatic Diseases. ISSN 0003-4967. doi: 10.1136/ard-2023-225073. Fulltekst i vitenarkiv
• Mulrooney, Elisabeth; Neogi, Tuhina; Dagfinrud, Hanne; Hammer, Hilde Berner; Pettersen, Pernille Steen & Kvien, Tore Kristian Aaserud [Vis alle 8 forfattere av denne artikkelen] (2024). Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2024.04.011. Fulltekst i vitenarkiv Vis sammendrag

  Objective Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored Design Latent class analysis determined classes of participants with hand OA from the Nor-Hand study baseline examination (2016–17) based on a biopsychosocial framework. Outcomes were hand and overall bodily pain intensity (Numeric Rating Scale, 0–10) at baseline and follow-up (2019–21), The relations of the classes to pain outcomes at baseline, follow-up, and change over time were analysed in separate models by linear regression, using the overall healthiest class as reference. Results Five classes differing in radiographic hand OA burden and OA burden in the lower extremities by ultrasound, demographic factors, psychosocial burden and pain sensitization was identified. Persons with the least severe OA but higher burden of biopsychosocial factors reported the most hand pain (beta 3.65, 95% CI 2.53, 4.75). Pain was less pronounced in persons with the most severe hand OA but low burden of biopsychosocial factors (beta 1.03, 95% CI 0.41, 1.65). Results were similar for overall bodily pain and at follow-up. Changes in pain were small, but the association between a separate class defined by higher levels of biopsychosocial burden and pain changes was significant. Conclusion The five hand OA phenotypes were associated with pain at baseline and 3.5 years later. The phenotype with the least OA severity, but higher burden of biopsychosocial factors reported more pain than the phenotype with the most severe OA, reflecting the symptom-structure discordance of the hand OA pain experience.

• Pettersen, Pernille; Haugmark, Trond; Berg, Inger Jorid; Hammer, Hilde Berner; Neogi, Tuhina & Zangi, Heidi Andersen [Vis alle 8 forfattere av denne artikkelen] (2024). Pain sensitization in fibromyalgia. Cross-sectional associations between quantitative sensory testing of pain sensitization and fibromyalgia disease burden. European Journal of Pain. ISSN 1090-3801. 29(1). doi: 10.1002/ejp.4771. Fulltekst i vitenarkiv
• Sharma, Hari A.; McAlindon, Timothy E.; Roberts, Mary B.; Bos-Haugen, Ida Kristin; Lo, Grace H. & Duryea, Jeffrey [Vis alle 10 forfattere av denne artikkelen] (2024). The natural history of marginal erosions in hands with and without osteoarthritis. Clinical Rheumatology. ISSN 0770-3198. doi: 10.1007/s10067-024-07116-x. Fulltekst i vitenarkiv
• Terpstra, Sietse E.S.; Stadt, Lotte A. van de; Berenbaum, Francis; Blanco, Francisco J.; Bos-Haugen, Ida Kristin & Mastbergen, Simon C. [Vis alle 10 forfattere av denne artikkelen] (2024). Severity and progression of structural hand OA is not associated with progression of structural knee OA: The IMI-APPROACH cohort. Osteoarthritis and Cartilage Open. 6(3). doi: 10.1016/j.ocarto.2024.100487. Fulltekst i vitenarkiv
• Moradi, Kamyar; Kwee, Robert M.; Mohajer, Bahram; Guermazi, Ali; Roemer, Frank W. & Ibad, Hamza Ahmed [Vis alle 9 forfattere av denne artikkelen] (2024). Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort. Annals of the Rheumatic Diseases. ISSN 0003-4967. doi: 10.1136/ard-2023-224997. Fulltekst i vitenarkiv
• Roemer, Frank W.; Jarraya, Mohamed; Hayashi, Daichi; Crema, Michel D.; Bos-Haugen, Ida Kristin & Hunter, David J. [Vis alle 7 forfattere av denne artikkelen] (2024). A perspective on the evolution of semi-quantitative MRI assessment of osteoarthritis: Past, present and future. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2024.01.001. Fulltekst i vitenarkiv
• Gløersen, Marthe; Hermann-Eriksen, Merete; Hove, Åshild; Kjeken, Ingvild; Mathiessen, Alexander & Hammer, Hilde Berner [Vis alle 7 forfattere av denne artikkelen] (2024). Lessons learned from the PICASSO trial regarding ultrasound examinations of osteoarthritic hand joints performed by occupational therapists. Ultraschall in der Medizin. ISSN 0172-4614. 45(3), s. 335–336. doi: 10.1055/a-2285-8206. Fulltekst i vitenarkiv Vis sammendrag

  Objective: Our primary objectives are to assess whether intraarticular corticosteroid injections are superior to saline injections with regards to thumb base pain after 4 weeks, and to compare the efficacy of steroid injections, saline injections, and an occupational therapy intervention on thumb base pain after 12 weeks in people with painful inflammatory osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint. Design: In this three-armed, double-blind, randomized multicenter trial, 354 participants with painful inflammatory CMC-1 OA from six Norwegian hospitals are recruited. Participants are randomized 1:1:1 to intraarticular steroid or saline injections in the CMC-1 joint or a multimodal occupational therapy intervention. The primary outcomes are thumb base pain measured on a numeric rating scale (NRS, range: 0-10) after 4 weeks and 12 weeks. Key secondary outcomes include synovitis by Magnetic Resonance Imaging (MRI) after 4 weeks and hand function by the Measure of Activity Performance of the Hand (MAP-Hand) questionnaire after 12 and 24 weeks. Other secondary outcomes are synovitis by clinical examination and ultrasound, measures of pain, function, stiffness, and health-related quality of life, and direct and indirect costs. Adverse events are recorded at each visit. The duration of the randomized controlled trial is 24 weeks, followed by an 80-week open-label observational phase to investigate the long-term efficacy and safety of repeated steroid injections and the occupational therapy intervention. Conclusions: The results from this trial will have important clinical implications and influence future guidelines on OA management of the CMC-1 joint.

• Bayramoglu, Neslihan; Englund, Martin; Bos-Haugen, Ida Kristin; Ishijima, Muneaki & Saarakkala, Simo (2023). Deep Learning for Predicting Progression of Patellofemoral Osteoarthritis Based on Lateral Knee Radiographs, Demographic Data and Symptomatic Assessments. Methods of Information in Medicine. ISSN 0026-1270. doi: 10.1055/a-2305-2115. Fulltekst i vitenarkiv
• Heiss, Rafael; Laredo, Jean-Denis; Wirth, Wolfgang; Jansen, Mylène P.; Marijnissen, Anne C.A. & Lafeber, Floris [Vis alle 14 forfattere av denne artikkelen] (2023). Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion. Bone. ISSN 8756-3282. 168. doi: 10.1016/j.bone.2023.116673. Fulltekst i vitenarkiv
• Gløersen, Marthe; Pettersen, Pernille Steen; Neogi, Tuhina; Sexton, Joseph; Kvien, Tore Kristian Aaserud & Hammer, Hilde Berner [Vis alle 7 forfattere av denne artikkelen] (2023). Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study. Osteoarthritis and Cartilage. ISSN 1063-4584. 31(10), s. 1388–1395. doi: 10.1016/j.joca.2023.07.005. Fulltekst i vitenarkiv Vis sammendrag

  Objective To examine whether pain sensitization is associated with hand and lower extremity function in people with hand osteoarthritis (OA) in the Nor-Hand study. Design Pain sensitization was assessed by pressure pain thresholds (PPTs) and temporal summation (TS). Hand function was assessed by Australian/Canadian Osteoarthritis Hand Index (AUSCAN) (range: 0–36), grip strength and Moberg pick-up test, and lower extremity function was assessed by Western Ontario and McMaster Universities Osteoarthritis Index (range: 0–68), 30-s chair stand test, and 40-m walk test. We examined whether sex-standardized PPT and TS values were cross-sectionally associated with measures of physical function using linear regression analyses. Beta coefficients were presented per sex-specific standard deviation of PPT and TS. The mediating effect of pain was examined by causal-inference based mediation analysis. Results In 206 participants, higher PPTs at/near the hand, indicative of less peripheral and/or central pain sensitization, were associated with greater grip strength and better self-reported hand function (beta for PPT at finger joint on AUSCAN function: −1.41, 95% CI −2.40, −0.42). Higher PPTs at/near the hand, near the knee and at trapezius were associated with lower extremity function, although not statistically significant for all outcomes. Self-reported pain severity mediated the effect of PPT on self-reported function. TS was not associated with hand or lower extremity function. Conclusion Peripheral sensitization, and possibly central sensitization, was associated with impaired function. Effects of PPTs on self-reported function were mediated by self-reported pain, whereas there might be a direct effect of sensitization or effects through other mediators on performance-based function.

• Mulrooney, Elisabeth; Neogi, Tuhina; Dagfinrud, Hanne; Hammer, Hilde Berner; Pettersen, Pernille Steen & Gløersen, Marthe [Vis alle 9 forfattere av denne artikkelen] (2023). Comorbidities in people with hand OA and their associations with pain severity and sensitization: Data from the longitudinal Nor-Hand study. Osteoarthritis and Cartilage Open. 5(3). doi: 10.1016/j.ocarto.2023.100367. Fulltekst i vitenarkiv Vis sammendrag

  Objective To determine whether the comorbidity burden and co-existing comorbidities are cross-sectionally and/or longitudinally associated with pain and pain sensitization in a cohort study of people with hand OA. Design We examined whether comorbidity burden and individual comorbidities based on the self-administered Comorbidity Index (range: 0–42) at baseline were associated with pain outcomes at baseline and 3 years follow-up. Pain outcomes included hand and overall bodily pain (range: 0–10) as well as pressure pain thresholds at the tibialis anterior muscle (kg/cm2) and temporal summation (distal radioulnar joint) as measures of central pain sensitization. We performed linear regression analyses adjusted for age, sex, body mass index, physical exercise and education. Results We included 300 and 196 participants in cross-sectional and longitudinal analyses, respectively. Using baseline data, the burden of comorbidities was associated with greater pain in hands (beta ​= ​0.61, 95% CI 0.37, 0.85) and overall body (beta ​= ​0.60, 95% CI 0.37, 0.87). Similar strength of associations was found between comorbidity burden (baseline) and follow-up pain. Among the individual comorbidities, back pain and depression were associated with nearly one unit higher pain score in hands and overall body at both baseline and follow-up. Only back pain was related to lower pressure pain thresholds at follow up (beta ​= ​−0.24, 95% CI −0.50, −0.001). Conclusion People with hand OA and greater comorbidity burden, co-existing back pain or depression reported greater pain severity than their counterparts, also 3 years later. These results acknowledge the relevance of accounting for comorbidities in the pain experience in people with hand OA.

• Liew, Jean W.; King, Lauren K.; Mahmoudian, Armaghan; Wang, Qiuke; Atkinson, Hayden F. & Flynn, David B. [Vis alle 13 forfattere av denne artikkelen] (2023). A scoping review of how early-stage knee osteoarthritis has been defined. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2023.04.015. Fulltekst i vitenarkiv
• Widera, Paweł; Welsing, Paco M.J.; Danso, Samuel O.; Peelen, Sjaak; Kloppenburg, Margreet & Loef, Marieke [Vis alle 21 forfattere av denne artikkelen] (2023). Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study. Osteoarthritis and Cartilage Open. 5(4). doi: 10.1016/j.ocarto.2023.100406. Fulltekst i vitenarkiv
• Jansen, Mylène P.; Wirth, Wolfgang; Bacardit, Jaume; Helvoort, Eefje M. van; Marijnissen, Anne C.A. & Kloppenburg, Margreet [Vis alle 15 forfattere av denne artikkelen] (2023). Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort. Quantitative Imaging in Medicine and Surgery (QIMS). ISSN 2223-4292. 13(5), s. 3298–3306. doi: 10.21037/qims-22-949. Fulltekst i vitenarkiv
• Døssing, Anna; Henriksen, Marius; Ellegaard, Karen; Nielsen, Sabrina Mai; Stamp, Lisa K & Müller, Felix C [Vis alle 20 forfattere av denne artikkelen] (2023). Colchicine twice a day for hand osteoarthritis (COLOR): a double-blind, randomised, placebo-controlled trial. The Lancet Rheumatology. 5(5), s. e254–e262. doi: 10.1016/S2665-9913(23)00065-6. Fulltekst i vitenarkiv
• Driban, Jeffrey B.; Vo, Nhung; Duryea, Jeff; Schaefer, Lena F.; Haugen, Ida K. & Eaton, Charles B. [Vis alle 9 forfattere av denne artikkelen] (2023). Hand joints without radiographic osteoarthritis maintain their joint space width over 4 years despite what's happening elsewhere in the hand. Rheumatology. ISSN 1462-0324. 63(7), s. 1850–1855. doi: 10.1093/rheumatology/kead480. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: We aimed to determine whether hand OA is characterized by systemic cartilage loss by assessing if radiographically normal joints had greater joint space width (JSW) loss over 4years in hands with incident or prevalent OA elsewhere in the hand compared with hands without OA. Methods: We used semi-automated software to measure JSW in the distal and proximal IP joints of 3368 participants in the Osteoarthritis Initiative who had baseline and 48-month hand radiographs. A reader scored 16 hand joints (including the thumb base) for Kellgren–Lawrence (KL) grade. A joint had OA if scored as KL 2. We identified three groups based on longitudinal hand OA status: no hand OA (KL

• Døssing, Anna; Nielsen, Sabrina Mai; Kroon, Féline P.B.; Balsby, Ida Maria; Tarp, Simon & Kloppenburg, Margreet [Vis alle 14 forfattere av denne artikkelen] (2023). Comparative effectiveness of pharmacological interventions for hand osteoarthritis: A systematic review and network meta-analysis of randomised trials. RMD Open. 9(3). doi: 10.1136/rmdopen-2023-003030. Fulltekst i vitenarkiv
• Ponnusamy, Raj; Zhang, Ming; Chang, Zhiheng; Wang, Yue; Guida, Carmine & Kuang, Samantha [Vis alle 15 forfattere av denne artikkelen] (2023). Automatic measuring of finger joint space width on hand radiograph using deep learning and conventional computer vision methods. Biomedical Signal Processing and Control. ISSN 1746-8094. 84. doi: 10.1016/j.bspc.2023.104713. Fulltekst i vitenarkiv Vis sammendrag

  Hand osteoarthritis (OA) severity can be assessed visually through radiographs using semi-quantitative grading systems. However, these grading systems are subjective and cannot distinguish minor differences. Joint space width (JSW) compensates for these disadvantages, as it quantifies the severity of OA by accurately measuring the distances between joint bones. Current methods used to assess JSW require users’ interaction to identify the joints and delineate the initial joint boundary, which is time-consuming. To automate this process and offer a robust measurement for JSW, we proposed two novel methods to measure JSW: (1) The segmentation-based (SEG) method, which uses traditional computer vision techniques to calculate JSW; (2) The regression-based (REG) method, which is a deep learning approach employing a modified VGG-19 network to predict JSW. On a dataset with 3591 hand radiographs, 10,845 DIP joints were cut as ROI and served as input to the SEG and REG methods. The bone masks of the ROI images generated by a U-Net model were sent as input in addition to the ROIs. The ground truth of JSW was labeled by a trained research assistant using a semi-automatic tool. Compared with the ground truth, the REG method achieved a correlation coefficient (r) of 0.88 and a mean square error (MSE) of 0.02 mm on the testing set; the SEG method achieved a correlation coefficient of 0.42 and an MSE of 0.15 mm. Results show the REG method has promising performance in JSW measurement and, in general, Deep Learning approaches can facilitate the automatic quantification of distance features in medical images.

• Jansen, Mylène P.; Roemer, Frank W.; Marijnissen, Anne Karien C. A.; Kloppenburg, Margreet; Blanco, Francisco J. & Bos-Haugen, Ida Kristin [Vis alle 11 forfattere av denne artikkelen] (2023). Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort. Skeletal Radiology. ISSN 0364-2348. doi: 10.1007/s00256-022-04259-3. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin; Felson, David; Abhishek, Abhishek; Berenbaum, Francis; Edwards, John James & Beaumont, Gabriel Herrero [Vis alle 33 forfattere av denne artikkelen] (2022). Development of radiographic classification criteria for hand osteoarthritis: a methodological report (Phase 2). RMD Open. 8(1). doi: 10.1136/rmdopen-2021-002024. Fulltekst i vitenarkiv
• Gløersen, Marthe; Pettersen, Pernille Steen; Neogi, Tuhina; Jafarzadeh, S. Reza; Vistnes, Maria & Thudium, Christian S. [Vis alle 11 forfattere av denne artikkelen] (2022). Associations of Body Mass Index With Pain and the Mediating Role of Inflammatory Biomarkers in People With Hand Osteoarthritis. Arthritis & Rheumatology. ISSN 2326-5191. 74(5), s. 810–817. doi: 10.1002/art.42056. Fulltekst i vitenarkiv Vis sammendrag

  Objective To examine the association of body mass index (BMI) with pain in people with hand osteoarthritis (OA), and explore whether this association, if causal, is mediated by systemic inflammatory biomarkers. Methods In 281 Nor-Hand study participants, we estimated associations between BMI and hand pain, as measured by the Australian/Canadian Osteoarthritis Hand Index (AUSCAN; range 0–20) and Numerical Rating Scale (NRS; range 0–10); foot pain, as measured by NRS (range 0–10); knee/hip pain, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC; range 0–20); painful total body joint count; and pain sensitization. We fit natural-effects models to estimate natural direct and natural indirect effects of BMI on pain through inflammatory biomarkers. Results Each 5-unit increase in BMI was associated with more severe hand pain (on average increased AUSCAN by 0.64 [95% confidence interval (95% CI) 0.23, 1.08]), foot pain (on average increased NRS by 0.65 [95% CI 0.36, 0.92]), knee/hip pain (on average increased WOMAC by 1.31 [95% CI 0.87, 1.73]), generalized pain, and pain sensitization. Mediation analyses suggested that the effects of BMI on hand pain and painful total body joint count were partially mediated by leptin and high-sensitivity C-reactive protein (hsCRP), respectively. Effect sizes for mediation by leptin were larger for the hands than for the lower extremities, and were statistically significant for the hands only. Conclusion In people with hand OA, higher BMI is associated with greater pain severity in the hands, feet, and knees/hips. Systemic effects of obesity, measured by leptin, may play a larger mediating role for pain in the hands than in the lower extremities. Low-grade inflammation, measured by hsCRP, may contribute to generalized pain in overweight/obese individuals.

• Stadt, de van de; Bos-Haugen, Ida Kristin; Felson, D. & Kloppenburg, M. (2022). Prolonged morning stiffness is common in hand OA and does not preclude a diagnosis of hand osteoarthritis. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2022.10.022. Fulltekst i vitenarkiv
• Loef, M.; Stadt, de van de; Böhringer, S.; Bay-Jensen, A.-C.; Mobasheri, A. & Larkin, J. [Vis alle 13 forfattere av denne artikkelen] (2022). The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort. Osteoarthritis and Cartilage. ISSN 1063-4584. 30(8), s. 1062–1069. doi: 10.1016/j.joca.2022.05.008. Fulltekst i vitenarkiv
• Mulrooney, Elisabeth; Neogi, Tuhina; Dagfinrud, Hanne; Hammer, Hilde Berner; Pettersen, Pernille Steen & Gaarden, Torfinn Lødøen [Vis alle 10 forfattere av denne artikkelen] (2022). The associations of psychological symptoms and cognitive patterns with pain and pain sensitization in people with hand osteoarthritis. Osteoarthritis and Cartilage Open. 4(2), s. 1–7. doi: 10.1016/j.ocarto.2022.100267. Fulltekst i vitenarkiv Vis sammendrag

  Objective To examine whether psychological symptoms and cognitive patterns are associated with self-reported pain and pain sensitization in people with hand osteoarthritis (OA). Design In the Nor-Hand study (n ​= ​300), people with hand OA self-reported psychological symptoms (Hospital Anxiety and Depression Scale), cognitive patterns (Pain catastrophizing Scale and Arthritis Self-Efficacy Scale) as well as their pain severity in hands, overall pain and multi-joint pain. Central pain sensitization was measured clinically by temporal summation and pressure pain threshold tests. We examined whether psychological symptoms and cognitive patterns were cross-sectionally associated with pain using linear regression. Beta coefficients (β) per one standard deviation of the independent variable were presented. Stratified analyses were performed in cases of significant interactions (p ​< ​0.10). Results Higher levels of anxiety, depressive symptoms and pain catastrophizing and low levels of self-efficacy were statistically significantly associated with higher levels of hand pain by Numeric Rating Scale (β ​= ​0.43, 0.48 and −0.57, respectively). Similar associations were found for overall pain, but not for measures of central pain sensitization. In stratified analyses, anxiety and depressive symptoms were more strongly related with pain in subgroups with younger age and higher comorbidity burden. Pain catastrophizing was more strongly related with pain in subgroups with younger age, overweight/obesity, higher comorbidity burden and poor sleep. Conclusion Psychological symptoms and cognitive patterns were associated with self-reported OA pain, especially in people with younger age, overweight/obesity, higher comorbidity burden and poor sleep. No associations were found for psychological symptoms and cognitive patterns with pain sensitization.

• Angelini, Federico; Widera, Paweł; Mobasheri, Ali; Blair, Joseph; Struglics, André & Uebelhoer, Melanie [Vis alle 16 forfattere av denne artikkelen] (2022). Osteoarthritis endotype discovery via clustering of biochemical marker data. Annals of the Rheumatic Diseases. ISSN 0003-4967. 81(5), s. 666–675. doi: 10.1136/annrheumdis-2021-221763. Fulltekst i vitenarkiv

Se alle arbeider i NVA

• Bos-Haugen, Ida Kristin (2026). Ny forskning: Tester kreftmedisin mot aggressiv håndartrose. [Journal]. Sykepleien. doi: https:/sykepleien.no/2026/01/ny-forskning-tester-kreftmedisin-mot-aggressiv-handartrose. Fulltekst i vitenarkiv
• Østerås, Nina & Bos-Haugen, Ida Kristin (2026). (+) Eksperter: Slik kan du redusere artrosesmertene. [Journal]. VG og VG+ papir og nettavis. Fulltekst i vitenarkiv Vis sammendrag

  Slankemedisiner kan bidra til mindre smerter i både knær, hofter og hender. Men når kiloene forsvinner, kan musklene gjøre det samme. For å unngå det, må du ha fokus på to ting.

• Bos-Haugen, Ida Kristin (2026). Behandlingsmuligheter for personer med håndartrose nå og framover. doi: https:/www.revmatiker.no/aktivitet/dialogseminaret-pa-diakonhjemmet-sykehus/. Fulltekst i vitenarkiv
• Daniloff, Kathrine & Bos-Haugen, Ida Kristin (2026). Kan et ganske vanlig legemiddel lindre artrose? [Journal]. forskning.no. Fulltekst i vitenarkiv Vis sammendrag

  Forskere undersøker nå om et legemiddel som brukes mot andre sykdommer, også kan lindre håndartrose.

• Bordvik, Daniel Huseby; Pettersen, Pernille Steen; Gløersen, Marthe; Mulrooney, Elisabeth; Neogi, Tuhina & Kjeken, Ingvild [Vis alle 7 forfattere av denne artikkelen] (2026). Fatigue severity and phenotypes in people with hand osteoarthritis - Results from the Nor-Hand study. Annals of Rheumatic diseases. 85(Supplement 1), s. 1751–1751. Fulltekst i vitenarkiv
• Bordvik, Daniel Huseby; Gløersen, Marthe; Mulrooney, Elisabeth; Pettersen, Pernille Steen; Sundbakk, Lene Maria & Neogi, Tuhina [Vis alle 8 forfattere av denne artikkelen] (2026). The interplay of fatigue in people with hand osteoarthritis - Results from the Nor-Hand study. Osteoarthritis and Cartilage. ISSN 1063-4584. 34(Supplement), s. 223–225. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin (2026). Eksperter: To grep kan redusere artrosesmertene. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin (2026). Medisinen som kan lindre artrose. Fulltekst i vitenarkiv
• Mahmoudian, Armaghan & Bos-Haugen, Ida Kristin (2026). Rethinking early-stage knee osteoarthritis beyond radiography. Nature Reviews Rheumatology. ISSN 1759-4790. 22(7), s. 410–410. doi: 10.1038/s41584-026-01389-z. Fulltekst i vitenarkiv
• Mahmoudian, Armaghan; King, Lauren K; Liew, Jean W; Wang, Qiuke; Berenbaum, Francis & Das, Siddharth [Vis alle 23 forfattere av denne artikkelen] (2025). Reframing early-stage symptomatic knee osteoarthritis (EsSKOA): A strategic lens for trial design. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2025.12.016. Fulltekst i vitenarkiv
• Kjeken, Ingvild & Bos-Haugen, Ida Kristin (2025). PICASSO-studien skal gi bedre behandling av tommelartrose. [Journal]. Ergoterapeuten digital og papirversjon. doi: https:/ipaper.ipapercms.dk/Ergoterapeuten/ergoterapeuten-nr-3-2025/. Fulltekst i vitenarkiv
• Kjeken, Ingvild; Bos-Haugen, Ida Kristin & Fryxelius, Anna (2025). Behandling av håndartrose: Oppdatering fra forskningsfronten. [Internet]. Revmatiker.no. doi: https:/www.revmatiker.no/aktivitet/forskningswebinar-behandling-av-handartrose/. Fulltekst i vitenarkiv
• Gløersen, Marthe; Kjeken, Ingvild; Tveter, Anne Therese; Kazemi, Amirhossein; Sexton, Joseph & Dziedzic, Krysia [Vis alle 38 forfattere av denne artikkelen] (2025). Study protocol for the PICASSO trial: A randomized placebo-controlled trial to investigate the efficacy and safety of intraarticular steroid injections and an occupational therapy intervention in painful inflammatory carpometacarpal-1 osteoarthritis. doi: 10.1016/j.ocarto.2024.100542. Fulltekst i vitenarkiv
• Mathiessen, Alexander; Gaundal, Line; Sexton, Joseph; Sjølie, Dag; Pettersen, Pernille Steen & Christensen, Barbara Therese Slatkovsky [Vis alle 7 forfattere av denne artikkelen] (2025). Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis. doi: 10.1016/j.ocarto.2024.100558. Fulltekst i vitenarkiv
• King, L.K.; Liew, J.W.; Mahmoudian, A.; Wang, Q.; Jansen, N.E.J. & Stanaitis, I. [Vis alle 26 forfattere av denne artikkelen] (2025). Corrigendum to “Multi-centre modified Delphi exercise to identify candidate items for classifying early-stage symptomatic knee osteoarthritis” [Osteoarthritis Cartilage (2025) 155–165, (S1063458424014481), (10.1016/j.joca.2024.10.016)]. Osteoarthritis and Cartilage. ISSN 1063-4584. 33(4), s. 530–533. doi: 10.1016/j.joca.2025.01.002. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin; Selmer, Kaja & Spildrejorde, Mari Roberts (2024). Smerteforskning. [Internet]. Revmatiker.no. doi: https:/www.revmatiker.no/aktivitet/forskningswebinar-om-smerteforskning-7-november/. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin (2024). Biomarkers for erosive vs non-erosive hand osteoarthritis: The Nor-Hand cohort. Fulltekst i vitenarkiv Vis sammendrag

  Martin Englund, Marthe Gløersen, Maria Vistnes, Aleksandra Turkiewicz, Anne C. Bay-Jensen, Christian S. Thudium, Muneaki Ishijima, Simo Saarakkala, Ida K. Haugen. Purpose (the aim of the study): Erosive hand osteoarthritis (EHOA) is a severe phenotype of hand OA associated with more pain, disability, joint inflammation, and bone erosions. Previous studies have suggested that people with EHOA have higher levels of systemic inflammation, e.g., measured by C-reactive protein (CRP), but the findings have not been consistent. Only a few studies have evaluated a broad set of biomarkers. Thus, we explored the potential associations between a set of plasma and serum biomarkers with EHOA and its radiographic progression. Our aims were: 1) to determine to what extent are plasma and serum biomarkers associated with EHOA among persons with hand OA. 2) to explore whether the biomarkers are associated with incidence and progression of EHOA. Methods: Nor-Hand is a prospective study of 300 persons with symptomatic hand OA from Oslo, Norway. There have been two study visits, in 2016/17 and 2019/21, respectively. People with other systemic inflammatory joint disease or psoriasis were not included. We included data from 289 subjects who, at their first examination, had plasma and serum biomarkers measured with a Luminex assay and assays from Nordic Bioscience. The following 18 biomarkers were evaluated: a) cytokines: CCL2, CCL4, CXCL10, IL-1ra, IL-4, IL-6, IL-17, IL-18, TNF-α; b) resistin and leptin (adipose-derived hormones/factors), VEGF (signaling protein); c) hs-CRP, CPRM, huARGS; and d) C1M, C2M, C3M (collagen-related biomarkers). Radiographic severity and its progression were determined by a trained reader. Erosive status of the distal and proximal interphalangeal joints was determined using the Verbruggen Veys anatomical phase scoring system (N=normal, J=joint space narrowing phase, E=erosive phase, R=remodeled phase). Erosive joints included joints in E phase (“active stage”) and R phase (“end-stage”). EHOA was defined as at least one joint in E or R phase. We used logistic regression for binary outcomes and zero-truncated negative binomial regression for count outcomes. Models were adjusted for age, sex, height, weight, and presence of knee synovitis. Analyses on the associations between biomarkers and number of erosive joints were performed in those with EHOA. Missing biomarker values were multiply imputed for modeling with logistic regression, and analysis of count data was based on complete cases. All biomarkers (apart from huARGS) values were log2 transformed prior to analysis. Results: Of the 289 hand OA patients (mean age 61 yrs, 89% women, mean body mass index 27), EHOA was present in 100 (35%) at the first examination, and they had a median (IQR) number of active erosive joints (E phase) of 1(2) and median (IQR) number of end-stage joints (R phase) of 1(3). Cross-sectional analyses: Possible associations with presence of EHOA were found for hsCRP (odds ratio 1.2 [95% confidence interval 1.0, 1.4] per 2-fold higher biomarker value), CXCL10 (1.4 [1.0, 1.8]) and IL-17 (1.3 [1.0, 1.6]). We found indications for a negative association with EHOA for the pro-inflammatory cytokine CCL2 (0.6 [0.3, 1.0]). Within the patient subset with EHOA, the estimates for C1M and IL-18 indicated positive associations for number of erosive joints (both E and R phase) and number of joints in E phase. However, none of the biomarkers was consistently associated with both presence of EHOA and number of affected joints with the exception of IL-17. Longitudinal analyses: Follow-up radiographs were available in 192 persons. Of the 122 subjects without EHOA at the first examination, 8% (n=10) had a new erosive joint at follow-up. Of the 70 persons with EHOA at baseline, 43 (61%) had a new erosive joint at follow-up. We found no clear associations with the biomarkers under evaluation and incidence or progression of EHOA. Due to small numbers, w

• Gløersen, Marthe; Pettersen, Pernille Steen; Maugesten, Øystein Gunnar; Mulrooney, Elisabeth; Mathiessen, Alexander & Gammelsrud, Heidi [Vis alle 14 forfattere av denne artikkelen] (2024). Corrigendum to “Study protocol for the follow-up examination of the Nor-Hand study: A hospital-based observational cohort study exploring pain and biomarkers in people with hand osteoarthritis” [Osteoarthr. Cartil. Open 3 (2021) 100198] (Osteoarthritis and Cartilage Open (2021) 3(3), (S2665913121000613), (10.1016/j.ocarto.2021.100198)). Osteoarthritis and Cartilage Open. 6(1). doi: 10.1016/j.ocarto.2022.100274. Fulltekst i vitenarkiv
• Olsen, Unni Solveig Johansen; Tveter, Anne Therese; Slatkowsky-Christensen, Barbara; Bos-Haugen, Ida Kristin; Hennig, Toril & Hermann-Eriksen, Merete [Vis alle 10 forfattere av denne artikkelen] (2024). Task-Shifting from rheumatologists to occupational therapists: no differences in care outcomes for hand osteoarthritis. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin (2024). An interational patient survey to identify candidate items for classifying early-stage symptomatic knee osteoarthritis. Fulltekst i vitenarkiv Vis sammendrag

  Lauren King, Armaghan Mahmoudian, Jean Liew, Quike WangIan Stanaitis, Dieuwke Schiphof, Leigh F. Callahan, David Hunter, C. Thomas Appleton, Aleksandra Turkiewicz, Martin Englund, Stefan Lohmander, Ida K. Haugen, Tuhina Neogi, Gillian Hawker, Jos Runhaar. Purpose (the aim of the study): The Osteoarthritis Research Society International has launched an initiative to develop classification criteria for early-stage symptomatic knee osteoarthritis (EsSKOA). The goal is to establish a standardized way to identify and enrol individuals with symptomatic knee OA but without established or later-stage knee OA into clinical studies, i.e., at an earlier stage of symptomatic disease. The classification criteria must accurately discriminate individuals with EsSKOA both from individuals with other causes for their knee symptoms and individuals with established or later-stage knee OA. The first phase(item generation)seeks to generate a comprehensive list to consider for the classification of EsSKOA. To incorporate patient perspectives into the first phase, our objectives were to 1)develop a list of symptoms which, according to individuals living with knee OA, emerged within the first year of symptom onset;and 2) identify symptoms, signs and/or tests perceived to have helped them and their health professional(s) indicate their symptoms were due to knee OA and not another condition. Methods: An international cross-sectional survey of people living with knee OA with a mixed-methods research approach. Between July–September2023, we recruited participants from four countries (Australia, Canada, Netherlands, USA). Included participants had to self-report a health-professional diagnosis of knee OA or be ≥45 years and report activity-related knee pain, and indicate ability to recall their earliest knee symptoms (within first year from symptom onset). Participants completed an online questionnaire which asked if they experienced changes to how their knee looked, felt, moved, and overall wellbeing within the first year of knee symptom onset (5-point Likert from “definitely experienced” to “definitely did not experience”), and if experienced changes, describe specific symptoms using free-text. Participants were asked about symptoms that made them consult a health professional, if applicable, and specific symptoms, signs and/or tests that they perceived helped them and their health professional know they had OA and not another cause for their symptoms. For quantitative data we calculated number and proportions or median and interquartile range, as appropriate. Analysis of free-text data was informed by conventional content analysis. Results: We included 92 participants; mean age 68 years, 69% woman, 91% reported health-professional diagnosis of knee OA, 27% reported onset of knee OA symptoms within the prior 5 years. Within the first year of experiencing knee symptoms, the majority of participants “definitely” or “probably” experienced a change in how their knee looked(68%), felt(86%), moved(60%), or impacted overall wellbeing(55%). Specific symptoms within the first year described by >10% of participants are shown in Table 2. Only 35% of participants reported they sought care from a health professional within the first year of experiencing symptoms. Symptoms, signs and/or tests that participants indicated helped to determine they had knee OA and not another cause for knee symptoms included: clinical history(14%), physical exam(17%), and radiographs or other imaging(51%). Conclusions: This international survey identified symptoms experienced by people living with knee OA within the first year of their illness. Given that few individuals seek healthcare within the first year, these provide key perspectives on the OA illness. Results of this study will be combined with results of a Delphi exercise with OA health professionals to generate a comprehensive list of items to be considered in subsequent phases of this initiative.

• Bos-Haugen, Ida Kristin (2024). Capability of Deep Learning to Detect Painful Knees in Osteoarthritis Using Radiographs: Comparison between Posterior-Anterior and Lateral Views. Fulltekst i vitenarkiv Vis sammendrag

  Neslihan Bayramoglu, Martin Englund, Ida K. Haugen, Muneaki Ishijima, Simo Saarakkala. Purpose (the aim of the study): Identifying knee osteoarthritis (OA) pain using deep learning (DL) techniques is an emerging area of research with the potential to significantly impact the diagnosis, treatment, and management. Previous imaging-oriented studies have primarily focused on frontal view X-rays, emphasizing the tibiofemoral (TF) joint. However, the lateral view, more suitable for imaging the patellofemoral (PF) joint, remains underexplored. In this study, our aim is to examine the capability of DL models to detect painful knees utilizing lateral view images, with a specific focus on the PF joint. The PF joint, known for its unique biomechanics and susceptibility to OA pain, presents a valuable subset of knee OA cases for investigation. Furthermore, this study aims to compare the detection performance of posterior–anterior (PA) fixed-flexion knee radiographs and lateral view radiographs. By evaluating and contrasting the detection performances of these two imaging modalities, we aim to shed light on their relative merits in assessing knee OA pain. Methods: We utilized baseline data from the MOST study with 1868 subjects and 3673 knees, assessing knee pain through WOMAC scores. Exclusions were made for knees without lateral view X-rays, lacking WOMAC assessments, or having failed landmark detection (Table 1). Out of the assessed knees, 66% exhibited pain (WOMAC >0), while 34% were pain-free (WOMAC = 0). Using BoneFinder software, we located landmarks, then utilized them to locate the joint ROI, ensuring consistent alignment of patellar and tibia bones. We conducted intensity normalization and developed distinct machine learning (ML) models for TF joint images in the PA view and PF joint images from lateral view radiographs to identify painful knees. Our ML models, based on deep CNN with a trainable attention module, were trained end-to-end. The VGG-16 architecture served as the backbone, initially pretrained on ImageNet. Evaluations used ROC-AUC and average precision (AP). We established a baseline model with clinical variables and explored complementary value by combining imaging models with clinical variables using multi-modal fusing models. Robustness was ensured through stratified subject-wise 5-fold cross-validation. Means and standard errors of the scores were estimated through bootstrapping. Results: The models trained on lateral and frontal views showed quite similar performance, with an ROC AUC of 0.69 and an AP of 0.81 (Figure 2). Combining predictions from both views introduced only a marginal increase (PF, TF). On the other hand, the clinical model achieved a lower performance, with an ROC AUC of 0.62 and an AP of 0.75. However, incorporating imaging predictions into the clinical model yielded a notable increase in ROC AUC (0.07) and AP (0.06), indicating the added value of imaging in identifying pain. Conclusions: This study introduced a DL method for the detection of knee pain from both frontal and lateral view knee X-rays. Results suggested that both projections exhibit similar performance to identify painful knees. Combination of both views did not significantly increase the detection performance. However, when compared to basic model (age, sex, BMI), X-ray has significant added value in pain detection. This suggests that, overall, imaging biomarkers play an important role in identifying OA pain.

• Bos-Haugen, Ida Kristin (2024). Trabecular bone texture is associated with anatomical phases of osteoarthrits evolution in finger joints: The Nor-Hand cohort. Fulltekst i vitenarkiv Vis sammendrag

  Marcin Wolski, Pawel Podsiadlo, Aleksandra Turkiewicz, Muneaki Ishijima, Simo Saarakkala, Martin Englund, da K Haugen Purpose (the aim of the study): Trabecular bone (TB) texture may serve as a biomarker for hand osteoarthritis (OA). In previous studies, differences have been found in TB texture between finger joints with and without radiographic OA, and associations have been reported between TB texture on hand radiographs and MRI-defined osteophytes in finger joints without radiographic OA. However, changes of TB texture with anatomical phases in the evolution of hand OA have not yet been studied. Thus, we explore such potential differences in TB texture in finger joints. Methods: An exploratory cross-sectional study was conducted using the baseline data from the Norwegian Hand OA (Nor-Hand) cohort which includes 300 persons (mean [SD] age of 61 [6] years, mean [SD] body mass index [BMI] of 27 [5], women 89%) with hand OA. The Nor-Hand participants did not have other systemic inflammatory joint disease or psoriasis. Second to fifth distal (DIP) and proximal (PIP) interphalangeal joints were graded according to the Verbruggen-Veys anatomical phase scoring system (N – normal, S – stationary, J – joint space narrowing, E – erosive, R – remodeled). On X-rays, distal and proximal TB texture regions of interest were automatically selected on the subchondral bone in the center of the bone epiphysis above and below the cortical plate of the DIP and PIP joints. An augmented variance orientation method was applied to each region; resulting in fractal dimensions (FDs) along the horizontal (FDH) and vertical (FDV) directions, and the direction of the roughest part of TB (FDSta). FDs measure the roughness of bone texture with higher values indicating rougher texture. Pairwise comparisons of the fractal parameters between finger joints in the normal phase (N) and those joints in the S, J, E and R phases (i.e., S-N, J-N, E-N, and R-N) by site (distal or proximal bone) were conducted using linear mixed models adjusted for age, sex, BMI, hand (right vs left), finger (two to five) and joint (DIP vs PIP). We allowed for interaction between phase and distal/proximal site within a joint. Random intercept for person and random slopes for DIP vs PIP joints and bone (distal vs proximal) were included to account for the clustered nature of the data. Results: The 300 hand OA patients had 2380 (50%), 2128 (45%), 96 (2%), 74 (2%), 80 (2%) PIP joints in the N, S, J, E and R phases, respectively. For DIP joints the numbers were 1087 (23%), 2700 (57%), 439 (5%), 229 (5%), and 300 (6%). Mean values of the fractal parameters calculated for the S, J, E and R phases were lower compared to those calculated for the normal (N) phase, by as much as one standard deviation in the erosive joints. The mean differences between the pairwise compared phases increase consistently, except for the R phase (Figure 1). The estimates were comparable for the distal and proximal bones. Conclusions: Trabecular bone texture roughness decreases with anatomical phases of OA evolution (progression) in finger joints. Our results suggest the loss of bone in the stationary, JSN, and erosive phases and the formation of new bone structure in the remodeled phase. Longitudinal studies are recommended to verify and further explore associations between TB texture and hand OA.

• Bos-Haugen, Ida Kristin (2024). Multi-centre modified Delphi exercise to identify important candidate items for classifying early-stage symptomatic knee osteoarthritis. Fulltekst i vitenarkiv Vis sammendrag

  Lauren King, Jean Liew, Quike Wang, Armaghan Mahmoudian, Ian Stanaitis, Jos Runhaar, C. Thomas Appleton, Aleksandra Turkiewicz, Martin Englund, Stefan Lohmander,Ida K. Haugen, Tuhina Neogi, Gillian Hawker. Purpose (the aim of the study): The Osteoarthritis Research Society International (OARSI) has launched an initiative to develop classification criteria for early-stage symptomatic knee osteoarthritis, EsSKOA. The goal is to provide a standardized way to identify and enrol individuals with symptomatic knee OA but without established or later-stage knee OA into clinical studies, i.e., at an earlier stage of symptomatic disease. The eventual classification criteria must accomplish two tasks; accurately discriminate individuals with EsSKOA from individuals with other causes for their knee symptoms, and from individuals with established or later-stage knee OA. This multi-phase initiative follows methodology established by American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) for developing classification criteria. Within the first phase, item generation, we sought to: 1) generate a list of candidate items OA clinicians and researchers (“experts”) identified as potentially useful for classification of EsSKOA; and 2) reduce this list of candidate items based on expert consensus. Methods: We conducted a three-round modified Delphi exercise via online surveys. We identified experts through an open call to OARSI membership and snowball sampling. In Round 1, participants reviewed candidate items generated from a literature review and other activities. Participants were asked to nominate additional item(s) they perceived useful in either of two tasks: discriminating individuals with EsSKOA from individuals with other causes for their knee symptoms, and from individuals with established or later-stage knee OA. We used conventional content analysis to analyze free-text responses. Any theme with data from ≥3 experts became a new candidate item and was added to the existing list to rate in Round 2. In Round 2, participants rated the perceived usefulness of each item (from 1 [totally useless] to 9 [extremely useful] or “unable to rate”) for each of the two tasks. We retained items for each task if the median usefulness score was >3 and ≥25% of responses in the “useful” (7,8,9) category. In Round 3, participants were presented their Round 2 rating for each item and task, the group median (25% and 75% percentiles) and given the opportunity to re-rate. Following Round 3, we retained items where the median usefulness score was >5 and ≥33.3% of responses in the “useful” (7,8,9) category. Results: We identified 222 individuals who were invited to participate. In Round 1, 128 participants completed the survey, followed by 116 participants in Round 2, and 103 participants in Round 3. There was variability in participant age, clinical and/or research discipline, gender and representation from five continents (Table 1). After Round 1, 27 items were added for a total of 108 items that underwent rating. After Round 2, 18 items were removed. After Round 3, 26 items were removed, leaving 64 candidate items within the following domains: patient demographic factors, symptoms, physical examination, performance-based physical function, imaging, laboratory investigations and gross inspection. 55 items were retained for discriminating only task 1 or 2, while 9 were retained for both (Figure 1). Conclusions: Within the first phase of classification criteria development, this Delphi exercise identified a set of items considered by OA clinicians and researchers as potentially useful in classifying a person presenting with undifferentiated knee symptoms as having EsSKOA. These items will be combined with data from a survey of persons living with knee OA. In the next phases of this initiative, candidate items will be further reduced using data-driven and consensus methods.

• Bos-Haugen, Ida Kristin (2024). Cartilage thickness mapping shows changes in distribution according to demographic and structural pathology features: Data from the IMI-APPROACH cohort. Fulltekst i vitenarkiv Vis sammendrag

  Mylène P. Jansen, Tom TurmezeiK, ishan Dattani, Dimitri A. Kessler, Simon Mastbergen, Margreet Kloppenburg, Francisco J Blanco-Garcia, Ida K. Haugen, Francis Berenbaum, Wolfgang Wirth, Felix Eckstein, Frank W. Roemer, James W. Mackay. Purpose (the aim of the study): Most participants of the IMI-APPROACH knee osteoarthritis (OA) cohort have cartilage loss, according to quantitative (segmentation-based) MRI analyses or MOAKS scoring, predominantly in the medial tibiofemoral compartment. Cartilage surface mapping (CaSM) is an alternative quantitative 3D analysis method that, unconstrained by subregion boundaries, can demonstrate how cartilage thickness varies across a joint and potentially determine regions of interest. The purpose of this study was to evaluate cartilage thickness distribution in knee OA patients using CaSM, and to analyze how this distribution depends on demographic and structural pathology features of OA. Methods: The cohort included 297 patients with clinical knee OA. 1.5T or 3T MRI 3D gradient echo sequences were acquired, on which semi-automatic cartilage segmentation of the femur and tibia was done using Stradview. Segmentations were registered to canonical surfaces using wxRegSurf, and analyzed in MATLAB. After evaluation of the whole-group average cartilage thickness, the influence of demographic and structural pathology features on cartilage thickness distribution was analyzed with statistical parametric mapping (SPM). SPM allows for vertex-wise comparisons and delivers multiple comparison-corrected F-test statistics, using the Surfstat MATLAB package and p<0.05 as the threshold for statistical significance. Sex, age and BMI were included as demographic factors. For structural features, presence of radiographic OA (ROA; Kellgren-Lawrence grade ≥2) and medial and lateral meniscal extrusion (MOAKS 0-3; scored on intermediate-weighted fat-suppressed sequences) were included in individual models. Results: 287 patients could be analyzed (age 66.4±7.1, BMI 28.0±5.2, 78% female, 55% ROA, 56/15% with medial/lateral meniscal extrusion). Average cartilage thickness with standard deviation is shown in Figure 1, indicating thinner cartilage most notably in the exterior region of the medial femur and the medial tibial surface compared to lateral. Male patients had significantly thicker cartilage across wide joint regions, especially the medial and lateral tibia and trochlea (Figure 2). Age also showed its most pronounced effect in the trochlea and (central) medial and lateral tibia, with older patients having thinner cartilage, while BMI was not significantly associated with cartilage thickness. Patients with ROA showed significantly thinner cartilage in parts of the medial and lateral tibia as well as the medial femur, but thicker cartilage in the trochlea and lateral femur (Figure 3). Patients with medial and lateral meniscus extrusion showed similar (opposing) effects, those with medial extrusion having significantly thinner cartilage in the medial compartment, and vice versa. Conclusions: Both demographic factors (age and sex) and structural pathology features (presence of ROA and meniscal extrusion) are significantly associated with cartilage thickness distribution throughout the joint in patients with clinical knee OA. Future analyses will indicate whether these and other factors are associated with longitudinal cartilage thickness changes.

• Bos-Haugen, Ida Kristin (2024). The association of severity and progression of structural hand OA with progression of structural knee OA: The IMI-APPROACH cohort. Fulltekst i vitenarkiv Vis sammendrag

  Sietse Terpstra, Lotte A. van de Stadt, Francis Berenbaum, Francisco J Blanco-Garcia, Ida K. Haugen, Simon Mastbergen, Harrie Weinans, Mylène P. Jansen, Frits R. Rosendaal, Margreet Kloppenburg. Purpose (the aim of the study):  Knee osteoarthritis (OA) lacks conclusive predictors of structural progression. An earlier study in patients with familial generalized OA has shown that hand OA progression was associated with knee OA progression. Whether structural hand OA can predict knee OA progression in a population with symptomatic knee OA is unknown. Therefore, we investigated in patients with symptomatic knee OA whether structural hand OA or its progression associates with structural knee OA progression after two years. Methods: We used baseline and two-year follow-up data from the Applied Public-Private Research enabling OA Clinical Headway. Symptomatic hand and knee OA were defined using the ACR clinical criteria sets. Radiographs of both hands (DIP, PIP, CMC1, IPJ and STT; sum score 0-58) and knees were scored semi-quantitatively for osteophytes and joint space narrowing (JSN) according to the OARSI atlas (medial and lateral tibiofemoral joint; summated score for JSN 0-12; osteophytes; 0-24), and according to the Kellgren and Lawrence (KL) method (DIP, PIP, IP, MCP and CMC1 (range 0-4 for each joint, sum score hand 0-120, knee 0-8). Structural hand and knee OA were defined as any joint with KL > 1. Progressors were defined on a change on patient level above the minimal detectable change (MDC) (=2 points, except KL of the knees (1)). Knees were measured quantitatively with the Knee Image Digital Analysis (KIDA) for KIDA-osteophytes and joint space width (JSW). Progressors were defined on a change above the MDC of the most affected compartment of the index knee. Patients with OA-related surgery before follow-up were assigned the maximum score for the concerning joint (n=8, all hands), and as progressors if this occurred during follow-up (n=3, all knees). With logistic regression analyses, we calculated the odds ratios (ORs) with 95% confidence intervals (CIs) of hand OA severity and progression features (independent variables) versus knee OA progression features (dependent variables), adjusted for age, sex and BMI. Results: 221 participants were included (mean age 66, 77% women, mean BMI 27.7, 19% symptomatic hand OA, 57% structural knee OA, 69% structural hand OA). Progression of the hands depended on the radiologic feature and varied from 18-30% of patients, and of the knees from 14 to 36% (table 1). Osteophytes, JSN and KL of the hands at baseline were not associated with progression of these features of the knees. Osteophyte and JSN progression of the hands were negatively associated with osteophyte progression of the knees (table 1). JSN progression of the hands was not significantly associated with JSN progression of the knees, but osteophyte progression of the hands was positively associated with JSN progression of the knees. KL progression of the hands was not associated with KL progression of the knees. KIDA data was available for 210 patients, of whom the most affected compartment was the medial compartment in 185 patients (88%). Progression in the knee for KIDA-osteophytes and JSW was seen for 38% and 9%, respectively. Baseline osteophyte severity of the hands was associated with KIDA-osteophyte progression (adjusted OR 1.03 (1.01;1.06)), but not with JSW progression. Baseline JSN severity was not associated with KIDA-osteophyte or JSW progression. Osteophyte or JSN progression of the hands were both not associated with KIDA-osteophyte progression. Due to insufficient size of the groups with osteophyte or JSN progression of the hands and JSW progression, no ORs for these associations were calculated. Conclusions: We found no consistent associations between baseline hand OA scores or hand OA progression with knee OA progression after two years. Some associations were shown, depending largely on the

• Bos-Haugen, Ida Kristin (2024). Longitudinal stablity of molecular endotypes of knee osteoarthritis patients from the APPROACH cohort. Fulltekst i vitenarkiv Vis sammendrag

  Monica T. Hannani, Christian S. Thudium, Alfred C. Gellhorn, Jonathan Larkin, Christoph Ladel, Cecilie Bager, Morten Karsdal, André Struglics, Florian Lafeber, Simon Mastbergen, Melanie Uebelhoer, Francisco J Blanco-Garcia, Ida K. Haugen, Harrie Weinans, Margreet Kloppenburg, Francis Berenbaum, Jaume Bacardit, Anne C. Bay-Jensen.

• Bos-Haugen, Ida Kristin (2024). Examination of OA phenotyping using polygenic risk scores in the Multicenter Osteoarthritis Study. Fulltekst i vitenarkiv Vis sammendrag

  Michelle S. Yau, Tuhina Neogi, Paul C. Okoro, Ida K. Haugen, John A. Lynch, Frank W. Roemer, Ali Guermazi, Cora E. Lewis, James C. Torner, Michael Nevitt, David Felson.

• Bos-Haugen, Ida Kristin (2024). Effects of Knee Flexion on Minimal Joint Space Width Increase in Knee Osteoarthritis Patients in the IMI-APPROACH cohort. Fulltekst i vitenarkiv Vis sammendrag

  Eva Bax, Chien Nguyen, Roel J. Custers, Nienke van Egmond, Vahid Arbabi, Hassan Rayegan, Willem Paul Gielis, Claudia Lindner, Tim Cootes, Margreet Kloppenburg, Francisco J Blanco-Garcia, Ida K. Haugen, Francis Berenbaum, Mylène P. Jansen, Simon Mastbergen, Wolfgang Wirth, Felix Eckstein, Harrie Weinans.

• Bos-Haugen, Ida Kristin (2024). To optimize the diagnostic process of rheumatic dieseases affecting the hands using FOI. Fulltekst i vitenarkiv Vis sammendrag

  N. Stumper, J. Berger, E. Gedat, P. Hoff, G. Schmittat, G. R. Burmester, G. Krönke, M. Backhaus, I. K. Haugen, S. Ohrndorf. Background: Accurate and rapid diagnosis of rheumatic joint diseases is essential for further treatment decision. Early treatment initiation of different rheumatic diseases slows the progression and positively influence their courses [1-3]. Different rheumatic diseases affecting the hands present characteristic patterns and features in fluorescence optical imaging (FOI) [4,5]. Objectives: We tested an atlas of image features in FOI for their ability to differentiate various rheumatic joint diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), connective tissue disease (CTD) and osteoarthritis (OA), with the aim to simplify the early diagnostic process for rheumatic diseases affecting the hands by the identification of specific FOI criteria for each disease. Methods: FOI images from patients with RA, PsA, CTD and OA were analyzed by two readers blinded for diagnosis and calibrated against each other, using the prima vista mode (PVM) and the 5-phase model. Twenty-six different features were pre-defined and all images were scored according to these features. The feature frequency in each patient and phase (PVM, 5-phase) was counted and statistically analysed using a contingency table and common formulae: χ 2 , Diagnostic Odds ratio (DOR), true positive rate (TPR), true negative rate (TNR), positive predictive value (PPV), and negative predictive value (NPV). In a first step, OA as a non-inflammatory disease was compared with the other diseases (RA, PsA, CTD), while these diseases were distinguished from each other in a second step. Results: A total of 374 patients (N=115 RA patients; mean age 54.4; SD 12.6), PsA (N=59; 50.0; 11.4), CTD (N=111; 52.2; 14.9) and OA (N=89; 62.1; 7.4) were included in the analysis. In a first step, OA is best distinguished and excluded from the other diseases by the means of the five features M, K, r, R and U (Table 1). In a second step, the other three diseases can be differentiated from each other including 5 features for PsA and CTD vs. RA, 10 features for RA and CTD vs. PsA, and 4 features for RA and PsA vs. CTD) (Table 2). Examples of different features in FOI are given in the Figure 1. Conclusion: FOI feature analysis helps to differentiate typical rheumatic diseases affecting the hands from each other, which could both speed up and improve the diagnostic process, especially in the early arthritis clinic.

• Bos-Haugen, Ida Kristin (2023). Artikkel om at Eksem kan øke risikoen for artrose - kommentar fra oss. [Journal]. VG . Fulltekst i vitenarkiv
• Østerås, Nina; Bos-Haugen, Ida Kristin & Olsen, Sissel Urke (2023). Ny forskning: Desto færre artroseplager vil man få. [Internet]. VG+. Fulltekst i vitenarkiv
• Bos-Haugen, Ida Kristin (2023). NY BEHANDLING FOR HÅNDARTROSE. [Journal]. Dagblandet online og papirutgave. Fulltekst i vitenarkiv
• Østerås, Nina & Bos-Haugen, Ida Kristin (2023). Slik kan din vekt påvirke artrosen. [Journal]. VG. Fulltekst i vitenarkiv

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