Ivar Sjaastad

Professor II - Institutt for eksperimentell medisinsk forskning

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E-post ivar.sjaastad@medisin.uio.no

Brukernavn

Besøksadresse Kirkeveien 166 Bygg 7 0450 Oslo

Postadresse Postboks 4956 Nydalen OUS HF Ullevål sykehus 0424 Oslo

Last ned visittkort

Faglige interesser

Forsker på mekanismer for utvikling av hjertesvikt, med hovedfokus på avbildningsmetoder. Forskningsgruppen gjennomfører både prekliniske og kliniske studier. Mye av forskningen for tiden er fokusert rundt diastolisk dysfunksjon, som også er temaet for KG Jebsen senter for hjerteforskning.

Bakgrunn

Professor og avdelingsleder ved Institutt for eksperimentell medisinsk forskning.
Leder av KG Jebsen senter for hjerteforskning
spesialist i indremedisin og kardiologi, og tok sin doktorgrad ved UiO i 2001.

Emneord: Hjertesvikt, Hjerte kar og lunger, Hjerte

Sasi, Athiramol; Romaine, Andreas; Murugan Erusappan, Pugazendhi; Melleby, Arne Olav; Hasic, Almira & Dahl, Christen Peder [Vis alle 14 forfattere av denne artikkelen] (2023). Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development. Matrix Biology Plus. 19-20. doi: 10.1016/j.mbplus.2023.100135. Fulltekst i vitenarkiv
Vistnes, Maria; Murugan Erusappan, Pugazendhi; Sasi, Athiramol; Nordén, Einar Sjaastad; Bergo, Kaja Knudsen & Romaine, Andreas [Vis alle 22 forfattere av denne artikkelen] (2023). Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction. Cardiovascular Research (CVR). ISSN 0008-6363. 119(10), s. 1915–1927. doi: 10.1093/cvr/cvad078. Fulltekst i vitenarkiv
Nordén, Einar Sjaastad; Veras, Ioanni; Yadav, Prakash; Løken, Kari Gulbrandsen; Dishington, Hilde & Thorstensen, Christian [Vis alle 8 forfattere av denne artikkelen] (2023). Clinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery. Laboratory Animals. ISSN 0023-6772. doi: 10.1177/00236772231178417. Fulltekst i vitenarkiv
Hou, Yufeng; Laasmaa, Martin; Li, Jia; Shen, Xin; Manfra, Ornella & Nordén, Einar Sjaastad [Vis alle 12 forfattere av denne artikkelen] (2023). Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes. Nature Cardiovascular Research. ISSN 2731-0590. 2(3), s. 251–267. doi: 10.1038/s44161-022-00199-2.
Blom, Kjersti Benedicte; Kro, Grete Anette Birkeland; Midtvedt, Karsten; Jenssen, Trond; Reisæter, Anna Varberg & Rollag, Halvor [Vis alle 15 forfattere av denne artikkelen] (2023). Cytomegalovirus High-risk Kidney Transplant Recipients Show No Difference in Long-term Outcomes Following Preemptive Versus Prophylactic Management. Transplantation. ISSN 0041-1337. 107(8), s. 1846–1853. doi: 10.1097/TP.0000000000004615. Fulltekst i vitenarkiv
Tønnessen, Theis Christian; Ueland, Thor; Ahmed, Muhammad Shakil; Attramadal, Håvard; Sjaastad, Ivar & Vinge, Leif Erik (2023). Inflammatory augmentation of the delayed type hypersensitivity arthritis mouse model. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 132(6), s. 545–549. doi: 10.1111/bcpt.13864. Fulltekst i vitenarkiv
Andreassen, Kristine; Rixon, Chloe Louise; Hansen Haugsten, Marie; Hauge-Iversen, Ida Marie; Zhang, Lili & Sadredini, Mani [Vis alle 13 forfattere av denne artikkelen] (2023). Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 324(6), s. H881–H892. doi: 10.1152/ajpheart.00701.2022.
Skogestad, Jonas; Albert, Ingrid; Hougen, Karina; Lothe, Gustav B; Lunde, Marianne & Eken, Olav Søvik [Vis alle 25 forfattere av denne artikkelen] (2023). Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice with Chronic Heart Failure. Circulation. ISSN 0009-7322. 147(16), s. 1221–1236. doi: 10.1161/CIRCULATIONAHA.121.054168.
Berger, Simon Girmai; NOMELAND, BIRGIT; Reiseter, Silje; Schwartz, Thomas; Andersson, Anna Helena & Hetlevik, Siri Opsahl [Vis alle 13 forfattere av denne artikkelen] (2023). Cardiac dysfunction in mixed connective tissue disease: a nationwide observational study. Rheumatology International. ISSN 0172-8172. s. 1055–1065. doi: 10.1007/s00296-023-05308-3. Fulltekst i vitenarkiv
Marstein, Henriette; NOMELAND, BIRGIT; Godang, Kristin; Olarescu, Nicoleta Cristina; Schwartz, Thomas & Flatø, Berit [Vis alle 10 forfattere av denne artikkelen] (2023). Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study. RMD Open. ISSN 2056-5933. 9:e002815(1), s. 1–9. doi: 10.1136/rmdopen-2022-002815. Fulltekst i vitenarkiv
Hansen Haugsten, Marie; Sadredini, Mani; Hasic, Almira; Anderson, Mark E.; Sjaastad, Ivar & Stokke, Mathis Korseberg (2022). CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKIIδ at methionines 281/282 is not a determining factor. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 175, s. 49–61. doi: 10.1016/j.yjmcc.2022.12.002. Fulltekst i vitenarkiv
Rypdal, Karoline Bjarnesdatter; Melleby, Arne Olav; Robinson, Emma Louise; Li, Jia; Palmero, Sheryl & Deborah E., Seifert [Vis alle 20 forfattere av denne artikkelen] (2022). ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload. Communications Biology. ISSN 2399-3642. 5(1). doi: 10.1038/s42003-022-04361-1. Fulltekst i vitenarkiv
Rixon, Chloe Louise; Andreassen, Kristine; Shen, Xin; Murugan Erusappan, Pugazendhi; Almaas, Vibeke Marie & Palmero, Sheryl [Vis alle 14 forfattere av denne artikkelen] (2022). Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy. ESC Heart Failure. ISSN 2055-5822. doi: 10.1002/ehf2.14234. Fulltekst i vitenarkiv
Lunde, Ida Gjervold; Aronsen, Jan Magnus; Melleby, Arne Olav; Strand, Mari Elen; Skogestad, Jonas & Bendiksen, Bård Andre [Vis alle 11 forfattere av denne artikkelen] (2022). Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy. Molecular Biology Reports. ISSN 0301-4851. 49(12), s. 11795–11809. doi: 10.1007/s11033-022-07985-y. Fulltekst i vitenarkiv
Shen, Xin; van den Brink, Jonas; Dahl, Anna; Kolstad, Terje R Selnes; Nordén, Einar Sjaastad & Hou, Yufeng [Vis alle 15 forfattere av denne artikkelen] (2022). Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure. eLIFE. ISSN 2050-084X. 11. doi: 10.7554/eLife.77725. Fulltekst i vitenarkiv
Støle, Thea Parsberg; Lunde, Marianne; Shen, Xin; Martinsen, Marita; Lunde, Per Kristian & Li, Jia [Vis alle 12 forfattere av denne artikkelen] (2022). The female syndecan-4−/− heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 10. doi: 10.3389/fcell.2022.908126. Fulltekst i vitenarkiv
Smith, Lisa; Skulberg, Vidar Magne; Zhang, Lili; Sjaastad, Ivar & Espe, Emil Knut Stenersen (2022). The effects of geometry on stiffness measurements in high-field magnetic resonance elastography: A study on rodent cardiac phantoms. Journal of The Mechanical Behavior of Biomedical Materials. ISSN 1751-6161. 133. doi: 10.1016/j.jmbbm.2022.105302. Fulltekst i vitenarkiv
Marstein, Henriette; Witczak, Birgit Nomeland; Godang, Kristin; Schwartz, Thomas; Flatø, Berit & Bollerslev, Jens [Vis alle 8 forfattere av denne artikkelen] (2022). Adipose tissue distribution is associated with cardio-metabolic alterations in adult patients with juvenile-onset dermatomyositis. Rheumatology. ISSN 1462-0324. 62(2), s. 1–9. doi: 10.1093/rheumatology/keac293. Fulltekst i vitenarkiv
Romaine, Andreas; Melleby, Arne Olav; Alam, Jahedul; Lobert, Viola; Lu, Ning & Lockwood, Francesca Eve [Vis alle 13 forfattere av denne artikkelen] (2022). Integrin α11β1 and syndecan-4 dual receptor ablation attenuates cardiac hypertrophy in the pressure overloaded heart. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 322(6), s. H1057–H1071. doi: 10.1152/ajpheart.00635.2021.
Udjus, Camilla; Sjaastad, Ivar; Hjørnholm, Ulla; Kinne Tunestveit, Torbjørn; Hoffmann, Pavel & Hinojosa, Alexis [Vis alle 11 forfattere av denne artikkelen] (2022). Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers. Physiological Reports. ISSN 2051-817X. 10(3). doi: 10.14814/phy2.15184. Fulltekst i vitenarkiv Vis sammendrag
Mountain climbing at high altitude implies exposure to low levels of oxygen, low temperature, wind, physical and psychological stress, and nutritional insufficiencies. We examined whether right ventricular (RV) and left ventricular (LV) myocardial masses were reversibly altered by exposure to extreme altitude. Magnetic resonance imaging and echocardiography of the heart, dual x-ray absorptiometry scan of body composition, and blood samples were obtained from ten mountain climbers before departure to Mount Everest or Dhaulagiri (baseline), 13.5 ± 1.5 days after peaking the mountain (post-hypoxia), and six weeks and six months after expeditions exceeding 8000 meters above sea level. RV mass was unaltered after extreme altitude, in contrast to a reduction in LV mass by 11.8 ± 3.4 g post-hypoxia (p = 0.001). The reduction in LV mass correlated with a reduction in skeletal muscle mass. After six weeks, LV myocardial mass was restored to baseline values. Extreme altitude induced a reduction in LV end-diastolic volume (20.8 ± 7.7 ml, p = 0.011) and reduced E’, indicating diastolic dysfunction, which were restored after six weeks follow-up. Elevated circulating interleukin-18 after extreme altitude compared to follow-up levels, might have contributed to reduced muscle mass and diastolic dysfunction. In conclusion, the mass of the RV, possibly exposed to elevated afterload, was not changed after extreme altitude, whereas LV mass was reduced. The reduction in LV mass correlated with reduced skeletal muscle mass, indicating a common denominator, and elevated circulating interleukin-18 might be a mechanism for reduced muscle mass after extreme altitude.
Tønnessen, Theis Christian; Melleby, Arne Olav; Hauge-Iversen, Ida Marie; Espe, Emil Knut Stenersen; Ahmed, Muhammad Shakil & Ueland, Thor [Vis alle 12 forfattere av denne artikkelen] (2022). Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice. PLOS ONE. ISSN 1932-6203. 17(1). doi: 10.1371/journal.pone.0262821. Fulltekst i vitenarkiv Vis sammendrag
Aims Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of an experimental model of RA in mice subjected to HF by constriction of the ascending aorta. Methods Aorta was constricted via thoracotomy and placement of o-rings with inner diameter 0.55 mm or 0.66 mm, or sham operated. RA-like phenotype was instigated by delayed-type hypersensitivity arthritis (DTHA) two weeks after surgery and re-iterated after additional 18 days. Cardiac magnetic resonance imaging (MRI) was performed before surgery and at successive time points throughout the study. Six weeks after surgery the mice were euthanized, blood and tissue were collected, organ weights were documented, and expression levels of cardiac foetal genes were analysed. In a supplemental study, DTHA-mice were euthanized throughout 14 days after induction of arthritis, and blood was analysed for important markers and mediators of RA (SAP, TNF-α and IL-6). In order to put the latter findings into clinical context, the same molecules were analysed in serum from untreated RA patients and compared to healthy controls. Results Significant elevations of inflammatory markers were found in both patient- and murine blood. Furthermore, the DTHA model appeared clinically relevant when compared to the inflammatory responses observed in three prespecified RA severity disease states. Two distinct trajectories of cardiac dysfunction and HF development were found using the two o-ring sizes. These differences were consistent by both MRI, organ weights and cardiac foetal gene expression levels. Still, no difference within the HF groups, nor within the sham groups, could be found when DTHA was induced. Conclusion DTHA mediated systemic inflammation did not cause, nor modify HF caused by aortic constriction. This indicates other prerequisites for RA-induced cardiac dysfunction.
Harbo, Markus Borge; Stokke, Mathis Korseberg; Sjaastad, Ivar & Espe, Emil Knut Stenersen (2022). One step closer to myocardial physiology: From PV loop analysis to state-of-the-art myocardial imaging. Acta Physiologica. ISSN 1748-1708. 234(2). doi: 10.1111/apha.13759.
NOMELAND, BIRGIT; Schwartz, Thomas; Barth, Zoltan; Taraldsrud, Eli; Samersaw-Lund, May Brit & Aaløkken, Trond Mogens [Vis alle 9 forfattere av denne artikkelen] (2022). Associations between cardiac and pulmonary involvement in patients with juvenile dermatomyositis—a cross-sectional study. Rheumatology International. ISSN 0172-8172. 42, s. 1213–1220. doi: 10.1007/s00296-021-05071-3. Fulltekst i vitenarkiv
Robinson, Emma L.; Drawnel, Faye M.; Mehdi, Saher; Archer, Caroline R.; Liu, Wei & Okkenhaug, Hanneke [Vis alle 15 forfattere av denne artikkelen] (2022). MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy. Cells. ISSN 2073-4409. 11(4). doi: 10.3390/cells11040604. Fulltekst i vitenarkiv
Blom, Kjersti Benedicte; Åsberg, Anders; Sjaastad, Ivar; Kalleberg, Karl Trygve; Søraas, Arne Vasli & Midtvedt, Karsten [Vis alle 7 forfattere av denne artikkelen] (2021). Kidney Transplant Recipient Behavior During the Early COVID-19 Pandemic: A National Survey Study in Norway. Kidney Medicine. 4(2). doi: 10.1016/j.xkme.2021.09.006. Fulltekst i vitenarkiv
Carlson, Cathrine Rein; Aronsen, Jan Magnus; Bergan Dahl, Anna; Moutty, Marie Christine; Lunde, Marianne & Lunde, Per Kristian [Vis alle 22 forfattere av denne artikkelen] (2021). AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR. Circulation Research. ISSN 0009-7330. 130(1), s. 27–44. doi: 10.1161/CIRCRESAHA.120.317976. Fulltekst i vitenarkiv
Wanichawan, Pimthanya; Skogestad, Jonas; Lunde, Marianne; Støle, Thea Parsberg; Stensland, Maria & Nyman, Tuula Anneli [Vis alle 10 forfattere av denne artikkelen] (2021). Design of a proteolytically stable sodium-calcium exchanger 1 activator peptide for in vivo studies. Frontiers in Pharmacology. ISSN 1663-9812. 12(638646). doi: 10.3389/fphar.2021.638646. Fulltekst i vitenarkiv
NOMELAND, BIRGIT; Bollerslev, Jens; Godang, Kristin; Schwartz, Thomas; Flatø, Berit & Molberg, Øyvind [Vis alle 8 forfattere av denne artikkelen] (2021). Body composition in long-standing juvenile dermatomyositis: associations with disease activity, muscle strength and cardiometabolic measures. Rheumatology. ISSN 1462-0324. 61(7), s. 2959–2968. doi: 10.1093/rheumatology/keab805. Fulltekst i vitenarkiv
Danielsen, Tore Kristian; Sadredini, Mani; Manotheepan, Ravinea; Aronsen, Jan Magnus; Frisk, Michael & Hansen Haugsten, Marie [Vis alle 13 forfattere av denne artikkelen] (2021). Exercise training stabilizes RyR2-dependent Ca2+ release in post-infarction heart failure. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 7. doi: 10.3389/fcvm.2020.623922. Fulltekst i vitenarkiv
Edwards, Andrew G.; Mørk, Halvor Kjeang; Stokke, Mathis Korseberg; Lipsett, David Bruce; Sjaastad, Ivar & Richard, Sylvain [Vis alle 8 forfattere av denne artikkelen] (2021). Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse. Frontiers in Physiology. ISSN 1664-042X. 12, s. 1–13. doi: 10.3389/fphys.2021.744730.
Sadredini, Mani; Manotheepan, Ravinea; Lehnart, Stephan E.; Anderson, Mark E.; Sjaastad, Ivar & Stokke, Mathis K. (2021). The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1. Physiological Reports. ISSN 2051-817X. 9(18). doi: 10.14814/phy2.15030. Fulltekst i vitenarkiv
Sadredini, Mani; Hansen Haugsten, Marie; Frisk, Michael; Louch, William E.; Lehnart, Stephan E. & Sjaastad, Ivar [Vis alle 7 forfattere av denne artikkelen] (2021). CaMKII inhibition has dual effects on spontaneous Ca2+release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 321(2), s. H446–H460. doi: 10.1152/ajpheart.00011.2021.
Bendiksen, Bård Andre; Mcginley, Gary George; Sjaastad, Ivar; Zhang, Lili & Espe, Emil Knut Stenersen (2021). A 4D continuous representation of myocardial velocity fields from tissue phase mapping magnetic resonance imaging. PLOS ONE. ISSN 1932-6203. 16(3). doi: 10.1371/journal.pone.0247826.
Marstein, Henriette; Godang, Kristin; Flatø, Berit; Sjaastad, Ivar; Bollerslev, Jens & Sanner, Helga (2021). Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study. Pediatric Rheumatology. ISSN 1546-0096. 19(1), s. 1–11. doi: 10.1186/s12969-021-00543-z. Fulltekst i vitenarkiv
Norden, Einar Sjaastad; Bendiksen, Bård Andre; Andresen, Henriette; Bergo, Kaja Knudsen; Espe, Emil Knut Stenersen & Hasic, Almira [Vis alle 12 forfattere av denne artikkelen] (2021). Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload. ESC Heart Failure. ISSN 2055-5822. 8(2), s. 918–927. doi: 10.1002/ehf2.13177.
Berger, Simon Girmai; Sjaastad, Ivar & Stokke, Mathis Korseberg (2021). Right ventricular involvement in hypertrophic cardiomyopathy: evidence and implications from current literature. Scandinavian Cardiovascular Journal. ISSN 1401-7431. s. 1–10. doi: 10.1080/14017431.2021.1901979. Fulltekst i vitenarkiv
Frisk, Michael; Le, Christopher; Shen, Xin; Røe, Åsmund Treu; Hou, Yufeng & Manfra, Ornella [Vis alle 24 forfattere av denne artikkelen] (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. Journal of the American College of Cardiology. ISSN 0735-1097. 77(4), s. 405–419. doi: 10.1016/j.jacc.2020.11.044. Fulltekst i vitenarkiv
Espe, Emil Knut Stenersen; Bendiksen, Bård Andre; Zhang, Lili & Sjaastad, Ivar (2020). Analysis of right ventricular mass from magnetic resonance imaging data: a simple post-processing algorithm for correction of partial-volume effects. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 320(2), s. 912–922. doi: 10.1152/ajpheart.00494.2020.
Longobardi, S.; Lewalle, A.; Coveney, S.; Sjaastad, Ivar; Espe, Emil Knut Stenersen & Louch, William Edward [Vis alle 9 forfattere av denne artikkelen] (2020). Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats: Aortic banded rat heart simulations. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. ISSN 1364-503X. 378(2173). doi: 10.1098/rsta.2019.0334.
Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud & Alfsnes, Katrine [Vis alle 25 forfattere av denne artikkelen] (2020). Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction. JACC: Basic to Translational Science. ISSN 2452-302X. 5(12), s. 1210–1224. doi: 10.1016/j.jacbts.2020.09.013. Fulltekst i vitenarkiv
Longobardi, Stefano; Lewalle, Alexandre; Coveney, Sam; Sjaastad, Ivar; Espe, Emil Knut Stenersen & Louch, William Edward [Vis alle 9 forfattere av denne artikkelen] (2020). Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. ISSN 1364-503X. 378(2173). doi: 10.1098/rsta.2019.0334. Fulltekst i vitenarkiv
Sokolova, Marina; Yang, Kuan; Hansen, Simen Hyll; Louwe, Maria Cornelia; Kummen, Martin & Hov, Johannes Espolin Roksund [Vis alle 12 forfattere av denne artikkelen] (2020). NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet. Scientific Reports. ISSN 2045-2322. 10:21006, s. 1–16. doi: 10.1038/s41598-020-76497-1. Fulltekst i vitenarkiv
Herum, Kate Louise Møller; Romaine, Andreas; Wang, Ariel; Melleby, Arne Olav; Strand, Mari Elen & Pacheco, Julian [Vis alle 16 forfattere av denne artikkelen] (2020). Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 9(3). doi: 10.1161/JAHA.119.013518. Fulltekst i vitenarkiv
Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Pisconti, Addolorata; Høst, Vibeke & Lunde, Marianne [Vis alle 11 forfattere av denne artikkelen] (2020). Syndecan-4–/– Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. doi: 10.3389/fcell.2020.00730. Fulltekst i vitenarkiv Vis sammendrag
Background: Extracellular matrix (ECM) remodeling is essential for skeletal muscle development and adaption in response to environmental cues such as exercise and injury. The cell surface proteoglycan syndecan-4 has been reported to be essential for muscle differentiation, but few molecular mechanisms are known. Syndecan-4–/– mice are unable to regenerate damaged muscle, and display deficient satellite cell activation, proliferation, and differentiation. A reduced myofiber basal lamina has also been reported in syndecan-4–/– muscle, indicating possible defects in ECM production. To get a better understanding of the underlying molecular mechanisms, we have here investigated the effects of syndecan-4 genetic ablation on molecules involved in ECM remodeling and muscle growth, both under steady state conditions and in response to exercise. Methods: Tibialis anterior (TA) muscles from sedentary and exercised syndecan-4–/– and WT mice were analyzed by immunohistochemistry, real-time PCR and western blotting. Results: Compared to WT, we found that syndecan-4–/– mice had reduced body weight, reduced muscle weight, muscle fibers with a smaller cross-sectional area, and reduced expression of myogenic regulatory transcription factors. Sedentary syndecan-4–/– had also increased mRNA levels of syndecan-2, decorin, collagens, fibromodulin, biglycan, and LOX. Some of these latter ECM components were reduced at protein level, suggesting them to be more susceptible to degradation or less efficiently translated when syndecan-4 is absent. At the protein level, TRPC7 was reduced, whereas activation of the Akt/mTOR/S6K1 and Notch/HES-1 pathways were increased. Finally, although exercise induced upregulation of several of these components in WT, a further upregulation of these molecules was not observed in exercised syndecan-4–/– mice. Conclusion: Altogether our data suggest an important role of syndecan-4 in muscle development.
Mohammadzadeh, Naiyereh; Melleby, Arne Olav; Palmero, Sheryl; Sjaastad, Ivar; Chakravarti, Shukti & Engebretsen, Kristin V Thunheim [Vis alle 9 forfattere av denne artikkelen] (2020). Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload. Cardiology. ISSN 0008-6312. 145(3), s. 187–198. doi: 10.1159/000505318.
Tazmini, Kiarash; Frisk, Michael; Lewalle, Alexandre; Laasmaa, Martin; Morotti, Stefano & Lipsett, David Bruce [Vis alle 16 forfattere av denne artikkelen] (2020). Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes. Circulation Research. ISSN 0009-7330. 126(7), s. 889–906. doi: 10.1161/CIRCRESAHA.119.315641. Fulltekst i vitenarkiv
Harbo, Markus Borge; Norden, Einar Sjaastad; Narula, Jagat; Sjaastad, Ivar & Espe, Emil Knut Stenersen (2020). Quantifying left ventricular function in heart failure: What makes a clinically valuable parameter? Progress in cardiovascular diseases. ISSN 0033-0620. s. 1–9. doi: 10.1016/j.pcad.2020.05.007. Fulltekst i vitenarkiv
Gonzalez, Alba; Nome, Cecilie; Bendiksen, Bård Andre; Sjaastad, Ivar; Zhang, Lili & Aleksandersen, Mona [Vis alle 9 forfattere av denne artikkelen] (2020). Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy. Epilepsy Research. ISSN 0920-1211. 161, s. 1–7. doi: 10.1016/j.eplepsyres.2020.106300. Fulltekst i vitenarkiv
Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Zhang, Lili & Sjaastad, Ivar (2019). Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 318(1), s. 143–153. doi: 10.1152/ajpheart.00357.2019. Fulltekst i vitenarkiv
Blom, Kjersti Benedicte; Bergo, Kaja Knudsen; Espe, Emil Knut Stenersen; Rosseland, Vigdis; Grøtta, Ole Jørgen & Mjøen, Geir [Vis alle 17 forfattere av denne artikkelen] (2019). Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study. Blood Pressure. ISSN 0803-7051. 29(2), s. 1–13. doi: 10.1080/08037051.2019.1684817. Fulltekst i vitenarkiv
Marstein, Henriette; Schwartz, Thomas; Aaløkken, Trond M; Samersaw-Lund, May Brit; Flatø, Berit & Sjaastad, Ivar [Vis alle 7 forfattere av denne artikkelen] (2019). Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross-sectional study of long-term disease. Rheumatology. ISSN 1462-0324. 59(8), s. 1862–1870. doi: 10.1093/rheumatology/kez531. Fulltekst i vitenarkiv
Berntsen, Kristin Schjander; Raastad, Truls; Marstein, Henriette; Kirkhus, Eva Astrid; Merckoll, Else & Cumming, Kristoffer Toldnes [Vis alle 9 forfattere av denne artikkelen] (2019). Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis; a Controlled Cross-Sectional Study. Arthritis & Rheumatology. ISSN 2326-5191. doi: 10.1002/art.41174. Fulltekst i vitenarkiv
Udjus, Camilla; Fadila, Cero; Halvorsen, Bente; Behmen, Dina; Carlson, Cathrine Rein & Bendiksen, Bård Andre [Vis alle 14 forfattere av denne artikkelen] (2019). Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 316(6), s. L999–L1012. doi: 10.1152/ajplung.00322.2018. Fulltekst i vitenarkiv
Mohammadzadeh, Naiyereh; Lunde, Ida Gjervold; Andenæs, Kine; Strand, Mari Elen; Aronsen, Jan Magnus & Skrbic, Biljana [Vis alle 15 forfattere av denne artikkelen] (2019). The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload. Scientific Reports. ISSN 2045-2322. 9:9206, s. 1–13. doi: 10.1038/s41598-019-45651-9. Fulltekst i vitenarkiv
Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus & Zhang, Lili [Vis alle 15 forfattere av denne artikkelen] (2019). NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity. Frontiers in Immunology. ISSN 1664-3224. 10:1621(JULY), s. 1–13. doi: 10.3389/fimmu.2019.01621. Fulltekst i vitenarkiv
Mcginley, Gary George; Bendiksen, Bård Andre; Zhang, Lili; Aronsen, Jan Magnus; Norden, Einar Sjaastad & Sjaastad, Ivar [Vis alle 7 forfattere av denne artikkelen] (2019). Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding. PLOS ONE. ISSN 1932-6203. 14:e0218874(7), s. 1–17. doi: 10.1371/journal.pone.0218874. Fulltekst i vitenarkiv
Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Eken, Olav Søvik; Sadredini, Mani; Myhre, Peder Langeland & Shen, Xin [Vis alle 24 forfattere av denne artikkelen] (2019). Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia. Circulation: Arrhythmia and Electrophysiology. ISSN 1941-3149. 12(4). doi: 10.1161/CIRCEP.118.007045. Fulltekst i vitenarkiv
Skogestad, Jonas; Lines, Glenn; Louch, William Edward; Sejersted, Ole M; Sjaastad, Ivar & Aronsen, Jan Magnus (2019). Evidence for heterogeneous subsarcolemmal Na+ Levels in rat ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 316(5). doi: 10.1152/ajpheart.00637.2018.
Mathiesen, Sabrina Bech; Lunde, Marianne; Aronsen, Jan Magnus; Romaine, Andreas; Kaupang, Anita & Martinsen, Marita [Vis alle 11 forfattere av denne artikkelen] (2019). The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP). Journal of Biological Chemistry. ISSN 0021-9258. 294(22), s. 8717–8731. doi: 10.1074/jbc.RA118.006423. Fulltekst i vitenarkiv Vis sammendrag
Costameres are signaling hubs at the sarcolemma and important contact points between the extracellular matrix and cell interior, sensing and transducing biomechanical signals into a cellular response. The transmembrane proteoglycan syndecan-4 localizes to these attachment points and has been shown to be important in the initial stages of cardiac remodeling, but its mechanistic function in the heart remains insufficiently understood. Here, we sought to map the cardiac interactome of syndecan-4 to better understand its function and downstream signaling mechanisms. By combining two different affinity purification methods with MS analysis, we found that the cardiac syndecan-4 interactome consists of 21 novel and 29 previously described interaction partners. Nine of the novel partners were further validated to bind syndecan-4 in HEK293 cells (i.e. CAVIN1/PTRF, CCT5, CDK9, EIF2S1, EIF4B, MPP7, PARVB, PFKM, and RASIP). We also found that 19 of the 50 interactome partners bind differently to syndecan-4 in the left ventricle lysate from aortic-banded heart failure (ABHF) rats compared with SHAM-operated animals. One of these partners was the well-known mechanotransducer muscle LIM protein (MLP), which showed direct and increased binding to syndecan-4 in ABHF. Nuclear translocation is important in MLP-mediated signaling, and we found less MLP in the nuclear-enriched fractions from syndecan-4-/- mouse left ventricles but increased nuclear MLP when syndecan-4 was overexpressed in a cardiomyocyte cell line. In the presence of a cell-permeable syndecan-4-MLP disruptor peptide, the nuclear MLP level was reduced. These findings suggest that syndecan-4 mediates nuclear translocation of MLP in the heart
Berntsen, Kristin Schjander; Edvardsen, Elisabeth; Hansen, Bjørge Hermann; Flatø, Berit; Sjaastad, Ivar & Sanner, Helga (2019). Cardiorespiratory fitness in long-term juvenile dermatomyositis: A controlled, cross-sectional study of active/inactive disease. Rheumatology. ISSN 1462-0324. 58(3), s. 492–501. doi: 10.1093/rheumatology/key342. Fulltekst i vitenarkiv Vis sammendrag
Objectives. To compare cardiorespiratory fitness (CRF) expressed as maximal oxygen uptake (VO2max) between patients with long-term JDM and controls and between patients with active and inactive disease, as well as to explore exercise limiting factors and associations between CRF and disease variables. Methods. JDM patients (n=45) and age- and gender-matched controls (n=45) performed a cardiopulmonary exercise test (CPET) on a treadmill until exhaustion. Physical activity was measured by accelerometers. Disease activity, damage and muscle strength/function were assessed by validated tools. Clinically inactive disease was defined according to PRINTO criteria. Results. The mean disease duration was 20.8 (S.D. 11.9) years and 29/45 (64%) patients had inactive disease. A low VO2max was found in 27% of patients vs 4% of controls (P = 0.006). The mean VO2max and maximal ventilation (VEmax) were lower in patients with active and inactive disease compared with controls. Patients with active disease also had lower maximal voluntary ventilation (MVV) compared with controls and lower VEmax and MVV compared with those with inactive disease. Patients with inactive disease had lower physical activity levels compared with controls. VO2max correlated negatively with disease damage in patients with inactive disease and positively with muscle strength/function in patients with active disease. Conclusion. CRF was lower in JDM patients, both with active and inactive disease, compared with controls after a mean 20 years disease duration. Cardiopulmonary exercise test results suggested different limiting factors contributing to the reduced CRF according to disease activity, including deconditioning in inactive disease and reduced ventilatory capacity in active disease. Further research is needed to verify this.
Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Buonarati, Olivia R. & Cataliotti, Alessandro [Vis alle 10 forfattere av denne artikkelen] (2019). Cardiomyocyte substructure reverts to an immature phenotype during heart failure. Journal of Physiology. ISSN 0022-3751. 597(7), s. 1833–1853. doi: 10.1113/JP277273. Fulltekst i vitenarkiv
Skogestad, Jonas; Aronsen, Jan Magnus; Tovsrud, Nils; Wanichawan, Pimthanya; Hougen, Karina & Stokke, Mathis Korseberg [Vis alle 10 forfattere av denne artikkelen] (2019). Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes . Cardiovascular Research (CVR). ISSN 0008-6363. 116(1), s. 78–90. doi: 10.1093/cvr/cvz087.
NOMELAND, BIRGIT; Hetlevik, Siri Opsahl; Sanner, Helga; Barth, Zoltan; Schwartz, Thomas & Flatø, Berit [Vis alle 8 forfattere av denne artikkelen] (2019). Cardiac function is impaired in longstanding juvenile-onset mixed connective tissue disease - a controlled study. Journal of Rheumatology. ISSN 0315-162X. 46(7), s. 739–747. doi: 10.3899/jrheum.180526. Fulltekst i vitenarkiv
Røe, Åsmund Treu; Ruud, Marianne; Espe, Emil Knut Stenersen; Manfra, Ornella; Longobardi, S & Aronsen, Jan Magnus [Vis alle 16 forfattere av denne artikkelen] (2019). Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression. Cardiovascular Research (CVR). ISSN 0008-6363. 115(4), s. 752–764. doi: 10.1093/cvr/cvy257.
Barth, Zoltan; Schwartz, Thomas; Flatø, Berit; Aaløkken, Trond Mogens; Koller, Akos & Lund, May-Brith [Vis alle 8 forfattere av denne artikkelen] (2019). The association between nailfold capillary density and pulmonary and cardiac involvement in medium-to long-standing juvenile dermatomyositis. Arthritis care & research. ISSN 2151-464X. 71(4), s. 492–497. doi: 10.1002/acr.23687. Fulltekst i vitenarkiv
Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani; Leren, Ida Skrinde; Edwards, Andrew & Vincent, Kevin P. [Vis alle 11 forfattere av denne artikkelen] (2018). Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation. PLOS ONE. ISSN 1932-6203. 13:e0207100(11), s. 1–21. doi: 10.1371/journal.pone.0207100. Fulltekst i vitenarkiv
Kolstad, Terje R Selnes; Brink, Jonas van Den; Macquaide, Niall; Lunde, Per Kristian; Frisk, Michael & Aronsen, Jan Magnus [Vis alle 13 forfattere av denne artikkelen] (2018). Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes. eLIFE. ISSN 2050-084X. 7. doi: 10.7554/eLife.39427. Fulltekst i vitenarkiv
Andenæs, Kine; Lunde, Ida Gjervold; Mohammadzadeh, Naiyereh; Dahl, Christen Peder; Aronsen, Jan Magnus & Strand, Mari Elen [Vis alle 11 forfattere av denne artikkelen] (2018). The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling. PLOS ONE. ISSN 1932-6203. 13(7), s. 1–20. doi: 10.1371/journal.pone.0201422. Fulltekst i vitenarkiv
Melleby, Arne Olav; Romaine, Andreas; Aronsen, Jan Magnus; Veras, Ioanni; Zhang, Lili & Sjaastad, Ivar [Vis alle 8 forfattere av denne artikkelen] (2018). A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice. Cardiovascular Research (CVR). ISSN 0008-6363. doi: 10.1093/cvr/cvy141. Fulltekst i vitenarkiv
Barth, Zoltan; NOMELAND, BIRGIT; Flatø, Berit; Koller, Akos; Sjaastad, Ivar & Sanner, Helga (2018). Assessment of Microvascular Abnormalities by Nailfold Capillaroscopy in Juvenile Dermatomyositis After Medium- to Long-Term Followup. Arthritis care & research. ISSN 2151-464X. 70(5), s. 768–776. doi: 10.1002/acr.23338.
Romaine, Andreas; Sørensen, Ida Wiig; Zeltz, Cedric; Lu, Ning; Erusappan, Pugazendhi Murugan & Melleby, Arne Olav [Vis alle 15 forfattere av denne artikkelen] (2017). Overexpression of integrin α11 induces cardiac fibrosis in mice. Acta Physiologica Scandinavica. ISSN 0001-6772. 222:e13025(2), s. 1–17. doi: 10.1111/apha.12932.
Røe, Åsmund Treu; Sjaastad, Ivar & Louch, William Edward (2017). Hjertesvikt med bevart ejeksjonsfraksjon [Heart failure with preserved ejection fraction]. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(18), s. 1–8. doi: 10.4045/tidsskr.16.1068.
Barth, Zoltan; Witzcak, Birgit; Flatø, Berit; Koller, Akos; Sjaastad, Ivar & Sanner, Helga (2017). Microvascular Abnormalities Assessed by Nailfold Capillaroscopy In Juvenile Dermatomyositis After Medium to Long-Term Follow-Up. Arthritis Care and Research. ISSN 0893-7524. doi: 10.1002/acr.23338.
Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C. & He, Chuan [Vis alle 13 forfattere av denne artikkelen] (2017). Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discovery. ISSN 2056-5968. 3. doi: 10.1038/celldisc.2017.13. Fulltekst i vitenarkiv
Røe, Åsmund Treu; Aronsen, Jan Magnus; Young-Halvorsen, Kristine Skårdal; Hamdani, Nazha; Linke, Wolfgang A. & Danielsen, Håvard Emil [Vis alle 9 forfattere av denne artikkelen] (2017). Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy. Cardiovascular Research (CVR). ISSN 0008-6363. 113(10), s. 1161–1172. doi: 10.1093/cvr/cvx087.
MANNER, INGJERD W; Waldum-Grevbo, Bård Endre; NOMELAND, BIRGIT; Bækken, Morten; Øktedalen, Olav & Os, Ingrid [Vis alle 8 forfattere av denne artikkelen] (2017). Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients. Blood Pressure. ISSN 0803-7051. 26(6), s. 332–340. doi: 10.1080/08037051.2017.1346459.
Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina & Skomedal, Tor [Vis alle 10 forfattere av denne artikkelen] (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology. ISSN 0014-2999. 812, s. 174–183. doi: 10.1016/j.ejphar.2017.07.014.
Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Eriksen, Morten; Sejersted, Ole M; Zhang, Lili & Sjaastad, Ivar (2017). Regional dysfunction after myocardial infarction in rats. Circulation Cardiovascular Imaging. ISSN 1941-9651. 10(9). doi: 10.1161/CIRCIMAGING.116.005997.
Gattoni, Sara; Røe, Åsmund Treu; Aronsen, Jan Magnus; Sjaastad, Ivar; Louch, William Edward & Smith, Nicolas P. [Vis alle 7 forfattere av denne artikkelen] (2017). Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding. Journal of Physiology. ISSN 0022-3751. 595(12), s. 3867–3889. doi: 10.1113/JP273879.
Johansen, Ida Beitnes; Sandblom, Erik; Skov, Peter V.; Gräns, Albin; Ekström, Andreas & Lunde, Ida Gjervold [Vis alle 13 forfattere av denne artikkelen] (2017). Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids. Journal of Experimental Biology. ISSN 0022-0949. 220(14), s. 2545–2553. doi: 10.1242/jeb.135046. Fulltekst i vitenarkiv
Aronsen, Jan Magnus; Espe, Emil Knut Stenersen; Young-Halvorsen, Kristine Skårdal; Hasic, Almira; Zhang, Lili & Sjaastad, Ivar (2017). Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 312(5), s. H932–H942. doi: 10.1152/ajpheart.00668.2016.
Berntsen, Kristin Schjander; Tollisen, Anita; Schwartz, Thomas; Kirkhus, Eva; Aaløkken, Trond Mogens & Samersaw-Lund, May Brit [Vis alle 9 forfattere av denne artikkelen] (2017). Submaximal exercise capacity in juvenile dermatomyositis after longterm disease: The contribution of muscle, lung, and heart involvement. Journal of Rheumatology. ISSN 0315-162X. 44(6), s. 827–834. doi: 10.3899/jrheum.160997.
Dhondup, Yangchen; Sjaastad, Ivar; Sandanger, Øystein; Aronsen, Jan Magnus; Ahmed, Muhammad Shakil & Attramadal, Håvard [Vis alle 14 forfattere av denne artikkelen] (2017). Toll-like receptor 9 promotes survival in SERCA2a KO heart failure mice. Mediators of Inflammation. ISSN 0962-9351. 2017:9450439, s. 1–11. doi: 10.1155/2017/9450439. Fulltekst i vitenarkiv
Thienpont, Bernard; Aronsen, Jan Magnus; Robinson, Emma Louise; Okkenhaug, Hanneke; Loche, Elena & Ferrini, Arianna [Vis alle 14 forfattere av denne artikkelen] (2017). The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy. Journal of Clinical Investigation. ISSN 0021-9738. 127(1), s. 335–348. doi: 10.1172/JCI88353.
Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Dahl, Mai Britt; Sandbu, Ragnhild Askeland & Johansen, Rune Forstrøm [Vis alle 15 forfattere av denne artikkelen] (2017). Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis. Circulation: Heart Failure. ISSN 1941-3289. 10(2). doi: 10.1161/CIRCHEARTFAILURE.116.003675.
Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine & Palibrk, Vuk [Vis alle 29 forfattere av denne artikkelen] (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports. ISSN 2211-1247. 18, s. 82–92. doi: 10.1016/j.celrep.2016.12.009. Fulltekst i vitenarkiv
Espe, Emil Knut Stenersen; Young-Halvorsen, Kristine Skårdal; Aronsen, Jan Magnus; Zhang, Lili & Sjaastad, Ivar (2017). A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data. Magnetic Resonance in Medicine. ISSN 0740-3194. 78(3), s. 1199–1207. doi: 10.1002/mrm.26486.
Schwartz, Thomas; Diederichsen, Louise Pyndt; Lundberg, Ingrid E.; Sjaastad, Ivar & Sanner, Helga (2016). Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies. RMD Open. ISSN 2056-5933. 2:e000291(2), s. 1–11. doi: 10.1136/rmdopen-2016-000291.

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Tønnessen, Theis; Christensen, Geir; Carlson, Cathrine Rein; Skrbic, Biljana & Sjaastad, Ivar (2022). Calcineurin-NFAT dynamics corresponds to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement. Frontiers in Molecular Medicine for Cardiology. doi: 10.3389/fmmed.2022.980717.
Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Høst, Vibeke; Pisconti, Addolorate & Lunde, Marianne [Vis alle 11 forfattere av denne artikkelen] (2019). Extracellular Matrix remodeling and multiple signaling pathways are regulated by syndecan-4 during myogenesis.
Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Høst, Vibeke; Liland, Kristian Hovde & Stang, Espen [Vis alle 10 forfattere av denne artikkelen] (2017). Syndecan-4 is a skeletal muscle regenerator and is important for normal skeletal muscle fibre development.
Strand, Mari Elen; Aronsen, Jan Magnus; Skrbic, Biljana; Gelazaukaite, Monika; Sjaastad, Ivar & Christensen, Geir Arve [Vis alle 7 forfattere av denne artikkelen] (2016). The heparanase-syndecan-4 axis in the heart: upregulation in response to immune activation indicates a role in cardiac inflammation.
Skogestad, Jonas; Albert, Ingrid; Marshall, Serena; Børstad, Mira Halvorsen; Lothe, Gustav B & Sejersted, Ole M [Vis alle 8 forfattere av denne artikkelen] (2016). Phosphodiesterase 2 regulates Na+/K+-ATPase activity in adult cardiomyocytes.
Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani; Leren, I.S.; Edwards, Andrew & Vincent, K. [Vis alle 11 forfattere av denne artikkelen] (2016). Mechanisms underlying the frequency-dependence of triggered arrhythmias in catecholaminergic polymorphic ventricular tachycardia type 1.
Ruud, Marianne; Frisk, Michael; Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Zhang, Lili & Norseng, Per Andreas [Vis alle 10 forfattere av denne artikkelen] (2016). Elevated ventricular wall stress disrupts cardiomyocyte t-tubular structure and Ca2+ homeostasis.
Mohammadzadeh, Naiyereh; Engebretsen, Kristin V Thunheim; Lunde, Ida Gjervold; Sjaastad, Ivar; Strand, Mari Elen & Marstein, Henriette [Vis alle 14 forfattere av denne artikkelen] (2016). Lack of the extracellular matrix proteoglycan lumican leads to cardiac dysfunction in response to pressure overload.
Mohammadzadeh, Naiyereh; Engebretsen, Kristin; Lunde, Ida Gjervold; Sjaastad, Ivar; Strand, Mari Elen & Marstein, Henriette [Vis alle 14 forfattere av denne artikkelen] (2016). Lack of the extracellular matrix proteoglycan lumican leads to ventricular dilatation, attenuated hypertrophy and contractile dysfunction in response to pressure overload.
Romaine, Andreas; Sørensen, Ida Wiig; Melleby, Arne Olav; Zeltz, Cedric; Zhang, Lili & Bendiksen, Bård Andre [Vis alle 12 forfattere av denne artikkelen] (2016). Overexpression of integrin a11 induces cardiac hypertrophy and fibrosis.
Melleby, Arne Olav; Strand, Mari Elen; Herum, Kate Louise Møller; Skrbic, Biljana; Dahl, Christen Peder & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2016). Glypican-6 is upregulated in heart failure and mediates cardiomyocyte growth through ERK1/2 signaling.
Marshall, Serena; Børstad, Mira Halvorsen; Skogestad, Jonas; Albert, Ingrid; Lothe, Gustav B & Espe, Emil Knut Stenersen [Vis alle 10 forfattere av denne artikkelen] (2016). SERCA2 activation is beneficial in chronic heart disease.

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Publisert 13. apr. 2011 11:44 - Sist endret 5. juli 2021 12:17