Kjetil Wessel Andressen

Førsteamanuensis - Avdeling for farmakologi
Bilde av Kjetil Wessel Andressen
English version of this page
Telefon +47 22840372
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postadresse Postboks 1057 Blindern 0316 Oslo

Faglige interesser

  • Forskning på hjertesvikt, cellulær signaloverføring og utvikling av nye legemidler.

Undervisning

  • Medisinstudiet: Farmakologi i modul 3-6.
  • Forskerkurs: Medansvarlig for MF9180 Mechanisms of cellular signal transduction.

Verv

Bakgrunn

Emneord: FRET, GPCR, cAMP, cGMP, Reseptor

Publikasjoner

  • Manfra, Ornella; Calamera, Gaia; Froese, Alexander; Arunthavarajah, Dulasi; Surdo, Nicoletta C. & Meier, Silja [Vis alle 14 forfattere av denne artikkelen] (2022). CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. Journal of Cardiovascular Research. ISSN 2059-0385. 118(6), s. 1506–1519. doi: 10.1093/cvr/cvab167.
  • Calamera, Gaia; Moltzau, Lise Roman; Levy, Finn Olav & Andressen, Kjetil Wessel (2022). Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts. International Journal of Molecular Sciences. ISSN 1661-6596. 23(4). doi: 10.3390/ijms23042145.
  • Danielsen, Tore Kristian; Sadredini, Mani; Manotheepan, Ravinea; Aronsen, Jan Magnus; Frisk, Michael & Hansen Haugsten, Marie [Vis alle 13 forfattere av denne artikkelen] (2021). Exercise training stabilizes RyR2-dependent Ca2+ release in post-infarction heart failure. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 7. doi: 10.3389/fcvm.2020.623922. Fulltekst i vitenarkiv
  • Jang, Wonjo; Adams, C. Elizabeth; Liu, Heng; Zhang, Cheng; Levy, Finn Olav & Andressen, Kjetil Wessel [Vis alle 7 forfattere av denne artikkelen] (2020). An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(48), s. 30755–30762. doi: 10.1073/pnas.2010801117. Fulltekst i vitenarkiv
  • Calamera, Gaia; Li, Dan; Ulsund, Andrea Hembre; Kim, Jeong Joo; Neely, Oliver C. & Moltzau, Lise Roman [Vis alle 11 forfattere av denne artikkelen] (2019). FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons. Communications Biology. ISSN 2399-3642. 2:394, s. 1–12. doi: 10.1038/s42003-019-0641-x. Fulltekst i vitenarkiv
  • Ulsund, Amanda Hembre; Dahl, Marie; Frimurer, Thomas; Manfra, Ornella; Schwartz, Thue W. & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2018). Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase. The FASEB Journal. ISSN 0892-6638. 33(3), s. 3870–3886. doi: 10.1096/fj.201800805RR.
  • Andressen, Kjetil Wessel; Ulsund, Andrea Hembre; Krobert, Kurt Allen; Lohse, Martin J.; Bünemann, Moritz & Levy, Finn Olav (2017). Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation. The FASEB Journal. ISSN 0892-6638. 32(2), s. 1059–1069. doi: 10.1096/fj.201700486R.
  • Moltzau, Lise Roman; Meier, Silja; Andressen, Kjetil Wessel & Levy, Finn Olav (2017). Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy. I Nikolaev, Viacheslav & Zaccolo, Manuela (Red.), Microdomains in the Cardiovascular System.. Springer. ISSN 978-3-319-54578-3. s. 245–271. doi: 10.1007/978-3-319-54579-0_12.
  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina & Skomedal, Tor [Vis alle 10 forfattere av denne artikkelen] (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology. ISSN 0014-2999. 812, s. 174–183. doi: 10.1016/j.ejphar.2017.07.014.
  • Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul & Levy, Finn Olav [Vis alle 9 forfattere av denne artikkelen] (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology. ISSN 0969-8051. 43(8), s. 478–489. doi: 10.1016/j.nucmedbio.2016.05.003.
  • Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W. & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2015). Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. ACS Chemical Neuroscience. ISSN 1948-7193. 6(7), s. 1206–1218. doi: 10.1021/cn500339p.
  • Andressen, Kjetil Wessel; Manfra, Ornella; Brevik, Christian Hellesylt; Ulsund, Andrea Hembre; Vanhoenacker, Peter & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2015). The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. British Journal of Pharmacology. ISSN 0007-1188. 172(15), s. 3846–3860. doi: 10.1111/bph.13169.
  • Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 8 forfattere av denne artikkelen] (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0115547. Fulltekst i vitenarkiv
  • Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel & Krobert, Kurt Allen [Vis alle 9 forfattere av denne artikkelen] (2015). Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis. Frontiers in Behavioral Neuroscience. ISSN 1662-5153. 9(MAY). doi: 10.3389/fnbeh.2015.00092. Fulltekst i vitenarkiv
  • Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård & Andressen, Kjetil Wessel [Vis alle 10 forfattere av denne artikkelen] (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm. ISSN 2040-2503. 6, s. 708–714. doi: 10.1039/c4md00486h.
  • Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman & Nilsen, Nils Olav [Vis alle 8 forfattere av denne artikkelen] (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(18), s. 4598–4602. doi: 10.1016/j.bmcl.2014.06.083.
  • Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(7), s. 1846–1850. doi: 10.1016/j.bmcl.2014.02.002.
  • Kilander, Michael Brita Christina; Petersen, Julian; Andressen, Kjetil Wessel; Ganji, Ranjani Sri; Levy, Finn Olav & Schuster, Jens [Vis alle 9 forfattere av denne artikkelen] (2014). Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. The FASEB Journal. ISSN 0892-6638. 28(5), s. 2293–2305. doi: 10.1096/fj.13-246363.
  • Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry. ISSN 0223-5234. 64, s. 629–637. doi: 10.1016/j.ejmech.2013.03.060.
  • Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 21(22), s. 7134–7145. doi: 10.1016/j.bmc.2013.09.004.
  • Gellynck, Evelien; Heyninck, Karen; Andressen, Kjetil Wessel; Haegeman, Guy; Levy, Finn Olav & Vanhoenacker, Peter [Vis alle 7 forfattere av denne artikkelen] (2013). The serotonin 5-HT7 receptors: two decades of research. Experimental Brain Research. ISSN 0014-4819. 230(4), s. 555–568. doi: 10.1007/s00221-013-3694-y.
  • Gellynck, Evelien; Andressen, Kjetil Wessel; Lintermans, Béatrice; Haegeman, Guy; Levy, Finn Olav & Vanhoenacker, Peter [Vis alle 7 forfattere av denne artikkelen] (2012). Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor. The FEBS Journal. ISSN 1742-464X. 279(11), s. 1994–2003. doi: 10.1111/j.1742-4658.2012.08581.x.
  • Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 18(24), s. 8600–8613. doi: 10.1016/j.bmc.2010.10.011.
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar & Dahl, Christen Peder [Vis alle 10 forfattere av denne artikkelen] (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology. ISSN 0007-1188. 155(7), s. 1005–1014. doi: 10.1038/bjp.2008.339.
  • Ngai, Jacob; Iversen, Trond Methi; Andressen, Kjetil Wessel; Levy, Finn Olav; Torgersen, Knut Martin & Vang, Torkel [Vis alle 8 forfattere av denne artikkelen] (2008). The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway. European Journal of Immunology. ISSN 0014-2980. 38(11), s. 3208–3218.
  • Gellynck, E; Laenen, K; Andressen, Kjetil Wessel; Lintermans, B; De Martelaere, K & Matthys, A [Vis alle 10 forfattere av denne artikkelen] (2008). Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain. Gene. ISSN 0378-1119. 426(1-2), s. 23–31. doi: 10.1016/j.gene.2008.08.011.
  • Vinge, Leif Erik; Andressen, Kjetil Wessel; Attramadal, Toril; Andersen, Geir Øystein; Ahmed, Muhammad Shakil & Peppel, K [Vis alle 12 forfattere av denne artikkelen] (2007). Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology. ISSN 0026-895X. 72, s. 582–591.
  • Andressen, Kjetil Wessel; Norum, Jens Henrik; Levy, Finn Olav & Krobert, Kurt Allen (2006). Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT7 receptor expression. Molecular Pharmacology. ISSN 0026-895X. 69, s. 207–215.
  • Krobert, Kurt Allen; Andressen, Kjetil Wessel & Levy, Finn Olav (2006). Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT7 serotonin receptor. European Journal of Pharmacology. ISSN 0014-2999. 532, s. 1–10.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Molenaar, P.; Birkeland, Jon Arne & Andressen, Kjetil Wessel [Vis alle 12 forfattere av denne artikkelen] (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure, Proceedings of the 25th European Section Meeting, International Society for Heart Research, Tromsø, Norway, June 21-25, 2005. Medimond. ISSN 88-7587-164-7. s. 7–12.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Andressen, Kjetil Wessel; Krobert, Kurt Allen & Birkeland, Jon Arne [Vis alle 11 forfattere av denne artikkelen] (2005). Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure. Cardiovascular Research (CVR). ISSN 0008-6363. 65.
  • Brattelid, Trond; Kvingedal, Ane Marit; Krobert, Kurt Allen; Andressen, Kjetil Wessel; Bach, Trond & Hystad, Marit Elise [Vis alle 8 forfattere av denne artikkelen] (2004). Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i). Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 369(6), s. 616–628.

Se alle arbeider i Cristin

  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Vis alle 9 forfattere av denne artikkelen] (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology. ISSN 2050-6511. 16, s. A66–A66. doi: 10.1186/2050-6511-16-S1-A66.
  • Dugstad, K.; Ulsund, Andrea Hembre; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2014). Unraveling tight spatial regulation of 5-HT4 receptor-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Dugstad, Kari Sandanger; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2012). Compartmented production and degradation of cAMP by beta-adrenergic, prostanoid and 5-HT4 receptors in CHF, visualized by FRET-based cAMP sensors.
  • Andressen, Kjetil Wessel; Dugstad, KS; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2011). Unraveling tight spatiotemporal regulation of cAMP-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 42(6), s. S152–S152.
  • Andressen, Kjetil Wessel; Norum, Jens Henrik; Levy, Finn Olav & Krobert, Kurt Allen (2006). Activation of adenylyl cyclase in HEK293 cells by endogenous G(s)-coupled receptors is attenuated by 5-HT7 receptor expression. Journal of Pharmacological Sciences (JPS). ISSN 1347-8613. 101, s. 128–128.
  • Qvigstad, Eirik; Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Andressen, Kjetil Wessel & Krobert, Kurt Allen [Vis alle 12 forfattere av denne artikkelen] (2005). Treatment of heart failure by blockade of ventricular myocardial serotonin receptors appearing in heart failure. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 38, s. 1041–1041.
  • Andressen, Kjetil Wessel & Levy, Finn Olav (2008). The 5-HT₇ serotonin receptor : G protein preassociation and functional selectivity. Unipub forlag. ISSN 978-82-8072-747-3.

Se alle arbeider i Cristin

Publisert 23. aug. 2012 12:14 - Sist endret 18. sep. 2018 13:42