Lorant Farkas

• Denholm, James; Schreiber, Benjamin A.; Jaeckle, Florian; Wicks, Mike N.; Benbow, Emyr W. & Bracey, Tim S. [Vis alle 23 forfattere av denne artikkelen] (2024). CD, or not CD, that is the question: a digital interobserver agreement study in coeliac disease. BMJ open gastroenterology. ISSN 2054-4774. 11(1). doi: 10.1136/bmjgast-2023-001252.
• Tahiri, Andliena; Puco, Katarina; Naji, Faris; Kristensen, Vessela N.; Alfsen, G. Cecilie & Farkas, Lorant [Vis alle 10 forfattere av denne artikkelen] (2022). Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors. OncoTarget. ISSN 1949-2553. 13(1), s. 970–981. doi: 10.18632/oncotarget.28257. Fulltekst i vitenarkiv Vis sammendrag

  Kinase activity is frequently altered in renal cell carcinoma (RCC), and tyrosine kinase inhibitors (TKIs) are part of the standard treatment strategy in patients with metastatic disease. However, there are still no established biomarkers to predict clinical benefits of a specific TKI. Here, we performed protein tyrosine kinase (PTK) profiling using PamChip® technology. The aim of this study was to identify differences in PTK activity between normal and malignant kidney tissue obtained from the same patient, and to investigate the inhibitory effects of TKIs frequently used in the clinics: sunitinib, pazopanib, cabozantinib and tivozanib. Briefly, our results showed that 36 kinase substrates differs (FDR < 0.05) between normal and cancer kidney tissue, where members of the Src family kinases and the phosphoinositide-3-kinase (PI3K) pathway exhibit high activity in renal cancer. Furthermore, ex vivo treatment of clear cell RCC with TKIs revealed that pathways such as Rap1, Ras and PI3K pathways were strongly inhibited, whereas the neurotrophin pathway had increased activity upon TKI addition. In our assay, tivozanib and cabozantinib exhibited greater inhibitory effects on PTK activity compared to sunitinib and pazopanib, implying they might be better suitable as TKIs for selected RCC patients.

• Dobson, Rachel; Du, Peter Y.; Ráso-Barnett, Livia; Yao, Wen-Qing; Chen, Zi & Casa, Calogero [Vis alle 21 forfattere av denne artikkelen] (2022). Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis. Haematologica. ISSN 0390-6078. 107(2), s. 489–499. doi: 10.3324/haematol.2020.265991.
• Melum, Guro Reinholt; Farkas, Lorant; Scheel, Cecilie; van Dieren, Brenda; Gran, Einar & Liu, YJ [Vis alle 9 forfattere av denne artikkelen] (2014). A thymic stromal lymphopoietin-responsive dendriticcell subset mediates allergic responses in the upper airway mucosa. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 134(3), s. 613–621. doi: 10.1016/j.jaci.2014.05.010.
• Skrindo, Ingebjørg; Farkas, Lorant; Kvale, Espen Østhagen; Johansen, Finn Eirik & Jahnsen, Frode Lars (2008). Depletion of CD4(+)CD25(+)CD127(lo) regulatory T cells does not increase allergen-driven T cell activation. Clinical and Experimental Allergy. ISSN 0954-7894. 38(11), s. 1752–1759. doi: 10.1111/j.1365-2222.2008.03081.x.
• Kvale, Espen Østhagen; Fløisand, Yngvar; Lund-Johansen, Fridtjof; Rollag, Halvor; Farkas, Lorant & Ghanekar, Smita [Vis alle 9 forfattere av denne artikkelen] (2007). Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells. Blood. ISSN 0006-4971. 109. doi: 10.1182/blood-2006-06-031484.
• Farkas, Lorant; Kvale, Espen Østhagen; Lund-Johansen, Fridtjof & Jahnsen, Frode Lars (2006). Plasmacytoid dendritic cells induce a distinct cytokine pattern in virus-specific CD4(+) memory T cells that is modulated by CpG oligodeoxynucleotides. Scandinavian Journal of Immunology. ISSN 0300-9475. 64, s. 404–411.
• Kvale, Espen Østhagen; Dalgaard, Jakob; Lund-Johansen, Fridtjof; Rollag, Halvor; Farkas, Lorant & Midtvedt, Karsten [Vis alle 9 forfattere av denne artikkelen] (2006). CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell–stimulatory capability upon infection. Blood. ISSN 0006-4971. 107(5), s. 2022–2029. doi: 10.1182/blood-2005-05-2016.
• Haddeland, Unni; Karstensen, AB; Farkas, Lorant; Bø, Knut Olav; Pirhonen, Jouko & Karlsson, Malin [Vis alle 9 forfattere av denne artikkelen] (2005). Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk. Pediatric Allergy and Immunology. ISSN 0905-6157. 16, s. 104–112.
• Farkas, Lorant; Kvale, Espen Østhagen; Johansen, Finn Eirik; Jahnsen, Frode Lars & Lund-Johansen, F (2004). Plasmacytoid dendritic cells activate allergen-specific Th2 memory cells: modulation by CpG oligodeoxynucleotides. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 114, s. 436–443.

Se alle arbeider i Cristin

• Farkas, Lorant; Schenck, Karl; Johansen, Finn-Eirik & Jahnsen, Frode L (2004). TSLP (thymic stromal lymphopoietin): a candidate target for treatment of allergy.
• Farkas, Lorant (2004). Human plasmacytoid dendritic cells: involvement in allergy, autoimmunity and virus reactions. Unipub forlag. ISSN 82-8072-139-8.

Se alle arbeider i Cristin