Magnus Nakrem Lyngbakken

• Young, Juliet; Lyngbakken, Magnus Nakrem; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2024). Systolic Blood Pressure, Diastolic Blood Pressure and Pulse Pressure and the Risk of Subclinical Myocardial Injury: The HUNT Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 13(9). doi: 10.1161/JAHA.123.031107.
• Aakre, Kristin Moberg; Lyngbakken, Magnus Nakrem; Faaren, Arne L.; Røsjø, Helge Rørvik; Dalen, Håvard & Omland, Torbjørn (2024). Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study. Clinical Chemistry and Laboratory Medicine. ISSN 1434-6621. doi: 10.1515/cclm-2024-0154.
• Bhatnagar, Rahul; Berge, Kristian; Røysland, Ragnhild; Høiseth, Arne Didrik; Brynildsen, Jon & Christensen, Geir [Vis alle 9 forfattere av denne artikkelen] (2023). Cardiac Troponin T and NT-proBNP for Prediction of 30-Day Readmission or Death in Patients with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study. Cardiology. ISSN 0008-6312. 148(6), s. 506–516. doi: 10.1159/000533266. Fulltekst i vitenarkiv
• Magnussen, Christina; Ojeda, Francisco M.; Leong, Darryl P.; Alegre-Diaz, Jesus; Amouyel, Philippe & Aviles-Santa, Larissa [Vis alle 91 forfattere av denne artikkelen] (2023). Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. New England Journal of Medicine. ISSN 0028-4793. 389(14), s. 1273–1285. doi: 10.1056/NEJMoa2206916. Fulltekst i vitenarkiv
• Handal, Nina; Whitworth, Jimmy; Lyngbakken, Magnus Nakrem; Berdal, Jan-Erik; Dalgard, Olav & Jørgensen, Silje Bakken (2023). Mortality and length of hospital stay after bloodstream infections caused by ESBL-producing compared to non-ESBL-producing E. coli. Infectious Diseases. ISSN 2374-4235. 56(1), s. 19–31. doi: 10.1080/23744235.2023.2261538. Fulltekst i vitenarkiv
• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Walle-Hansen, Marte; Hagberg, Guri & Ihle-Hansen, Hege Beathe [Vis alle 12 forfattere av denne artikkelen] (2023). Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 12(17), s. 1–10. doi: 10.1161/JAHA.123.030739. Fulltekst i vitenarkiv
• Berge, Kristian; Aengevaeren, Vincent L.; Mosterd, Arend; Velthuis, Birgitta K.; Lyngbakken, Magnus Nakrem & Omland, Torbjørn [Vis alle 8 forfattere av denne artikkelen] (2023). Plasma Advanced Glycation End Products and Dicarbonyl Compounds Are Not Associated with Coronary Atherosclerosis in Athletes. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 55(7), s. 1143–1150. doi: 10.1249/MSS.0000000000003152. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem; Kimenai, Dorien M.; Hveem, Kristian; Dalen, Håvard; Røsjø, Helge Rørvik & Omland, Torbjørn (2023). Patterns of Cardiac Troponin I Concentrations as Risk Predictors of Cardiovascular Disease and Death: The Trøndelag Health Study. American Journal of Medicine. ISSN 0002-9343. 136(9), s. 902–909.e4. doi: 10.1016/j.amjmed.2023.05.009. Fulltekst i vitenarkiv
• Kimenai, Dorien M.; Anand, Atul; de Bakker, Marie; Shipley, Martin; Fujisawa, Takeshi & Lyngbakken, Magnus Nakrem [Vis alle 18 forfattere av denne artikkelen] (2023). Trajectories of cardiac troponin in the decades before cardiovascular death: a longitudinal cohort study. BMC Medicine. ISSN 1741-7015. 21(1). doi: 10.1186/s12916-023-02921-8. Fulltekst i vitenarkiv
• Walle-Hansen, Marte; Berge, Trygve; Vigen, Thea; Myrstad, Marius; Hagberg, Guri & Ihle-Hansen, Hege Beathe [Vis alle 14 forfattere av denne artikkelen] (2022). Systolic blood pressure at age 40 and cognitive function 25 years later: The Akershus Cardiac Examination (ACE) 1950 Study. Journal of Hypertension. ISSN 0263-6352. 41(1), s. 132–139. doi: 10.1097/HJH.0000000000003312.
• Aagaard, Erika Nerdrum; Lyngbakken, Magnus Nakrem; Kvisvik, Brede Alexander Havneraas; Berge, Trygve; Pervez, Mohammad Osman & Ariansen, Inger Kristine Holtermann [Vis alle 10 forfattere av denne artikkelen] (2022). Associations between cardiovascular risk factors, biomarkers, and left ventricular mechanical dispersion: insights from the ACE 1950 Study . European Heart Journal Open (EHJ Open). 2(2), s. 1–10. doi: 10.1093/ehjopen/oeac006. Fulltekst i vitenarkiv
• Lång, Maarit; Jakob, Stephan M.; Takala, Riikka; Lyngbakken, Magnus Nakrem; Turpeinen, Anu & Omland, Torbjørn [Vis alle 14 forfattere av denne artikkelen] (2022). The prevalence of cardiac complications and their impact on outcomes in patients with non-traumatic subarachnoid hemorrhage. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-24675-8. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem; Rønningen, Peter Selmer; Solberg, Magnar Gangås; Berge, Trygve; Brynildsen, Jon & Aagaard, Erika Nerdrum [Vis alle 11 forfattere av denne artikkelen] (2022). Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes. Heart. ISSN 1355-6037. doi: 10.1136/heartjnl-2022-321608. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem; Kvisvik, Brede Alexander Havneraas; Berge, Trygve; Pervez, Mohammad Osman; Aagaard, Erika Nerdrum & Ariansen, Inger Kristine Holtermann [Vis alle 10 forfattere av denne artikkelen] (2022). Serial blood pressure measurements, left ventricular remodelling and cardiovascular outcomes. European Journal of Clinical Investigation. ISSN 0014-2972. 53(1). doi: 10.1111/eci.13876. Fulltekst i vitenarkiv Vis sammendrag

  Background Hypertension is a risk factor for the development of cardiovascular disease. Whether serial blood pressure (BP) measurements are more closely associated with subclinical left ventricular (LV) remodelling and better predict risk of cardiovascular events over individual BP measurements are not known. Methods We assessed systolic BP, diastolic BP and pulse pressure at several time points during adulthood in 1333 women and 1211 men participating in the Akershus Cardiac Examination 1950 Study. We defined serial BP measurements as the sum of averaged BPs from adjacent consecutive visits indexed to total exposure time between measurements. We assessed the associations between serial and individual BP measurements and (1) LV structure, function and volumes and (2) incident myocardial infarction, ischemic stroke, heart failure and cardiovascular death. Results All indices of higher serial BP measurements were associated with increased indexed LV mass, and the associations were stronger than those of individual BP measurements. Serial diastolic BP pressure was strongly and inversely associated with LV systolic function, while higher serial systolic BP was primarily associated with higher LV volumes. Both serial systolic (incidence rate ratio [IRR] 1.10, 95% CI 1.03 to 1.17) and diastolic BPs (IRR 1.14, 95% CI 1.02 to 1.27) were associated with increased incidence of clinical events. Conclusion In healthy community dwellers without established cardiovascular disease, different serial BP indices associate strongly with LV remodelling and cardiovascular outcomes. Whether the use of serial BP indices for guiding treatment is superior to individual measurements should be explored in additional prospective studies.

• Rønningen, Peter Selmer; Berge, Trygve; Solberg, Magnar Gangås; Enger, Steve; Pervez, Mohammad Osman & Orstad, Eivind Bjørkan [Vis alle 13 forfattere av denne artikkelen] (2022). Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid-60s: Data From the ACE 1950 Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 11(11). doi: 10.1161/JAHA.121.023738. Fulltekst i vitenarkiv
• Caspersen, Nina Faksvåg; Søyseth, Vidar; Lyngbakken, Magnus Nakrem; Berge, Trygve; Ariansen, Inger Kristine Holtermann & Tveit, Arnljot [Vis alle 8 forfattere av denne artikkelen] (2022). Treatable Traits in Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination 1950 Study. COPD: Journal of Chronic Obstructive Pulmonary Disease. ISSN 1541-2555. 9(2), s. 165–180. doi: 10.15326/jcopdf.2021.0265. Fulltekst i vitenarkiv
• Berge, Kristian; Brynildsen, Jon; Røysland, Ragnhild; Strand, Heidi; Christensen, Geir & Høiseth, Arne Didrik [Vis alle 9 forfattere av denne artikkelen] (2022). Prognostic value of cardiac biomarkers and National Early Warning Score 2 in acute dyspnoea. Open heart. ISSN 2053-3624. 9(1). doi: 10.1136/openhrt-2021-001938. Fulltekst i vitenarkiv
• Skranes, Julia Brox; Lyngbakken, Magnus Nakrem; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2022). Tobacco Consumption and High-Sensitivity Cardiac Troponin I in the General Population: The HUNT Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 11(2), s. 1–9. doi: 10.1161/JAHA.121.021776. Fulltekst i vitenarkiv
• Myhre, Peder Langeland; Lyngbakken, Magnus Nakrem; Berge, Trygve; Røysland, Ragnhild; Aagaard, Erika Nerdrum & Pervez, Mohammad Osman [Vis alle 13 forfattere av denne artikkelen] (2021). Diagnostic Thresholds for Pre-Diabetes Mellitus and Diabetes Mellitus and Subclinical Cardiac Disease in the General Population: Data From the ACE 1950 Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 10(11). doi: 10.1161/JAHA.120.020447. Fulltekst i vitenarkiv
• Axfors, Cathrine; Schmitt, Andreas; Janiaud, Perrine; Hooft, Janneke; Abd-Elsalam, Sherief & Abdo, Ehab [Vis alle 50 forfattere av denne artikkelen] (2021). Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nature Communications. ISSN 2041-1723. 12. doi: 10.1038/s41467-021-22446-z. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2021). Subclinical myocardial injury and risk of COVID-19 in the general population: The Trøndelag Health Study. Clinical Chemistry. ISSN 0009-9147. 68(3), s. 473–475. doi: 10.1093/clinchem/hvab267. Fulltekst i vitenarkiv
• Myhre, Peder Langeland; Heck, Siri Lagethon; Skranes, Julia Brox; Prebensen, Christian Haugland; Jonassen, Christine M & Berge, Trygve [Vis alle 15 forfattere av denne artikkelen] (2021). Cardiac pathology 6 months after hospitalization for COVID-19 and association with the acute disease severity. American Heart Journal. ISSN 0002-8703. 242, s. 61–70. doi: 10.1016/j.ahj.2021.08.001. Fulltekst i vitenarkiv
• Achenbach, Stephan; Aleksandrova, Krasimira; Amiano, Pilar; Amouyel, Philippe; Andersson, Jonas & Bakker, Stephan J.L. [Vis alle 50 forfattere av denne artikkelen] (2021). SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. European Heart Journal. ISSN 0195-668X. 42(25), s. 2439–2454. doi: 10.1093/eurheartj/ehab309. Fulltekst i vitenarkiv
• Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E & Hansen, Ailin Falkmo [Vis alle 30 forfattere av denne artikkelen] (2021). Genome-wide association study of cardiac troponin i in the general population. Human Molecular Genetics. ISSN 0964-6906. 30(21), s. 2027–2039. doi: 10.1093/hmg/ddab124. Fulltekst i vitenarkiv Vis sammendrag

  Circulating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) concentrations and its causal effect on cardiovascular phenotypes are unclear. We combine data from two large population-based studies, the Trøndelag Health Study and the Generation Scotland Scottish Family Health Study, and perform a genome-wide association study of high-sensitivity cTnI concentrations with 48 115 individuals. We further use two-sample Mendelian randomization to investigate the causal effects of circulating cTnI on acute myocardial infarction (AMI) and heart failure (HF). We identified 12 genetic loci (8 novel) associated with cTnI concentrations. Associated protein-altering variants highlighted putative functional genes: CAND2, HABP2, ANO5, APOH, FHOD3, TNFAIP2, KLKB1 and LMAN1. Phenome-wide association tests in 1688 phecodes and 83 continuous traits in UK Biobank showed associations between a genetic risk score for cTnI and cardiac arrhythmias, metabolic and anthropometric measures. Using two-sample Mendelian randomization, we confirmed the non-causal role of cTnI in AMI (5948 cases, 355 246 controls). We found indications for a causal role of cTnI in HF (47 309 cases and 930 014 controls), but this was not supported by secondary analyses using left ventricular mass as outcome (18 257 individuals). Our findings clarify the biology underlying the heritable contribution to circulating cTnI and support cTnI as a non-causal biomarker for AMI in the general population. Using genetically informed methods for causal inference helps inform the role and value of measuring cTnI in the general population.

• Lyngbakken, Magnus Nakrem; De Lemos, James A.; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2021). Lifetime obesity trends are associated with subclinical myocardial injury: The Trøndelag health study. Journal of Internal Medicine. ISSN 0954-6820. s. 1–10. doi: 10.1111/joim.13391. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem; Paulsen, Aksel; Sethupathy, Ashwini; Hesselberg, Øyvind; Grimsgaard, Sameline & Hagen, Knut (2021). Pragmatiske studier – hva er det? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(14). doi: 10.4045/tidsskr.21.0490. Fulltekst i vitenarkiv
• Sigurdardóttir, Fjóla Dögg; Lyngbakken, Magnus; Hveem, Kristian; Hrubos-Strøm, Harald; Røsjø, Helge & Redline, Susan [Vis alle 7 forfattere av denne artikkelen] (2021). Insomnia symptoms and subclinical myocardial injury: Data from the Nord-Trøndelag Health (HUNT) study. Journal of Sleep Research. ISSN 0962-1105. 30(5). doi: 10.1111/jsr.13299. Fulltekst i vitenarkiv
• Rutkovskiy, Arkady; Lyngbakken, Magnus; Dahl, Mai Britt; Bye, Anja; Pedersen, Marit Holmefjord & Wisløff, Ulrik [Vis alle 10 forfattere av denne artikkelen] (2021). Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study. Clinical Chemistry. ISSN 0009-9147. 67(6), s. 889–898. doi: 10.1093/clinchem/hvab030. Fulltekst i vitenarkiv Vis sammendrag

  Background MicroRNA (miR)-210 expression is induced by acute and chronic hypoxia and provides prognostic information in patients with aortic stenosis and acute coronary syndrome. We hypothesized that circulating miR-210 concentrations could provide diagnostic and prognostic information in patients with acute heart failure (HF). Methods We measured miR-210 concentrations in serum samples on admission from 314 patients hospitalized for acute dyspnea and 9 healthy control subjects. The diagnostic and prognostic properties of miR-210 were tested in patients after adjudication of all diagnoses and with median follow-up of 464 days. Results All patients and control subjects had miR-210 concentrations within the range of detection, and the analytical variation was low as the coefficient of variation of synthetic spike-in RNA was 4%. Circulating miR-210 concentrations were increased in patients with HF compared to healthy control subjects, but miR-210 concentrations did not separate patients with acute HF (n = 143) from patients with non-HF-related dyspnea (n = 171): the area under the curve was 0.50 (95% CI 0.43–0.57). Circulating miR-210 concentrations were associated with mortality (n = 114) after adjustment for clinical risk factors (hazard ratio 1.65 [95% CI 1.03–2.62] per unit miR-210 increase), but this association was attenuated and not significant after adjustment for established cardiac protein biomarkers. Conclusions Circulating miR-210 concentrations are associated with mortality, but do not add to established protein biomarkers for diagnosis or prognosis in patients with acute dyspnea.

• Lyngbakken, Magnus; Vigen, Thea; Ihle-Hansen, Håkon; Brynildsen, Jon; Berge, Trygve & Rønning, Ole M. [Vis alle 9 forfattere av denne artikkelen] (2021). Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study. Clinical Biochemistry. ISSN 0009-9120. 93, s. 59–65. doi: 10.1016/j.clinbiochem.2021.04.005. Fulltekst i vitenarkiv
• Lyngbakken, Magnus; Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Berge, Trygve; Pervez, Mohammad Osman & Brynildsen, Jon [Vis alle 10 forfattere av denne artikkelen] (2020). B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healtahy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study. Clinical Chemistry. ISSN 0009-9147. doi: 10.1093/clinchem/hvaa257. Fulltekst i vitenarkiv
• Lyngbakken, Magnus; Aagaard, Erika Nerdrum; Kvisvik, Brede Alexander; Berge, Trygve; Pervez, Mohammad Osman & Brynildsen, Jon [Vis alle 10 forfattere av denne artikkelen] (2020). Cardiac troponin I and T are associated with left ventricular function and structure: Data from the Akershus Cardiac Examination 1950 Study. Clinical Chemistry. ISSN 0009-9147. 66(4), s. 567–578. doi: 10.1093/clinchem/hvaa023. Fulltekst i vitenarkiv
• Berge, Kristian; Lyngbakken, Magnus; Myhre, Peder Langeland; Brynildsen, Jon; Røysland, Ragnhild & Strand, Heidi [Vis alle 10 forfattere av denne artikkelen] (2020). High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study. Clinical Biochemistry. ISSN 0009-9120. s. 1–7. doi: 10.1016/j.clinbiochem.2020.11.009. Fulltekst i vitenarkiv
• Røsjø, Helge; Hijazi, Ziad; Omland, Torbjørn; Westerbergh, Johan; Lyngbakken, Magnus & Alexander, J.H. [Vis alle 12 forfattere av denne artikkelen] (2020). Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial. Journal of Internal Medicine. ISSN 0954-6820. 288(2), s. 248–259. doi: 10.1111/joim.13072. Fulltekst i vitenarkiv
• Lyngbakken, Magnus; Berdal, Jan Erik; Eskesen, Arne N; Kvale, Dag; Olsen, Inge Christoffer & Rueegg, Corina Silvia [Vis alle 11 forfattere av denne artikkelen] (2020). A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics. Nature Communications. ISSN 2041-1723. 11:5284, s. 1–6. doi: 10.1038/s41467-020-19056-6. Fulltekst i vitenarkiv
• Aakre, Kristin Moberg; Omland, Torbjørn; Nordstrand, Njord; Gjevestad, Espen Svendsen; Holven, Kirsten Bjørklund & Lyngbakken, Magnus [Vis alle 7 forfattere av denne artikkelen] (2020). Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention. Clinical Biochemistry. ISSN 0009-9120. 86, s. 36–44. doi: 10.1016/j.clinbiochem.2020.09.006. Fulltekst i vitenarkiv
• Chandra, Anupam; Røsjø, Helge; Svensson, My Hanna Sofia; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Vis alle 14 forfattere av denne artikkelen] (2020). Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study. European Journal of Clinical Nutrition. ISSN 0954-3007. doi: 10.1038/s41430-020-0641-4. Fulltekst i vitenarkiv
• Chandra, Anupam; Lyngbakken, Magnus; Eide, Ivar Anders; Røsjø, Helge; Vigen, Thea & Ihle-Hansen, Håkon [Vis alle 13 forfattere av denne artikkelen] (2020). Plasma trans fatty acid levels, cardiovascular risk factors and lifestyle: Results from the Akershus cardiac examination 1950 study. Nutrients. ISSN 2072-6643. 12(5). doi: 10.3390/nu12051419. Fulltekst i vitenarkiv
• Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Vis alle 13 forfattere av denne artikkelen] (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-019-02007-3.
• Chandra, Anupam; Røsjø, H; Eide, A.I.; Vigen, T.; Ihle-hansen, H & Orstad, Eivind Bjørkan [Vis alle 13 forfattere av denne artikkelen] (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-019-02007-3.
• Aagaard, Erika Nerdrum; Kvisvik, Brede Alexander; Pervez, Mohammad Omar; Lyngbakken, Magnus; Berge, Trygve & Enger, Steve [Vis alle 12 forfattere av denne artikkelen] (2019). Left ventricular mechanical dispersion in a general population: Data from the Akershus Cardiac Examination 1950 study. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 21. doi: 10.1093/ehjci/jez210.
• Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Mørkrid, Lars; Røsjø, Helge; Lyngbakken, Magnus & Smedsrud, Marit Kristine [Vis alle 11 forfattere av denne artikkelen] (2019). Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 35, s. 1265–1275. doi: 10.1007/s10554-019-01583-z. Fulltekst i vitenarkiv
• Myhre, Peder Langeland; Lyngbakken, Magnus; Tveit, Sjur Hansen; Røsjø, Helge & Omland, Torbjørn (2019). Cardiac imaging and circulating biomarkers for primary prevention in the era of precision medicine. Expert Review of Precision Medicine and Drug Development. ISSN 2380-8993. 4(5), s. 299–308. doi: 10.1080/23808993.2019.1660162. Fulltekst i vitenarkiv
• Vigen, Thea; Ihle-Hansen, Håkon; Lyngbakken, Magnus; Berge, Trygve; Thommessen, Bente & Ihle-Hansen, Hege [Vis alle 11 forfattere av denne artikkelen] (2019). Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index. Journal of Neuroimaging (JON). ISSN 1051-2284. doi: 10.1111/jon.12684. Fulltekst i vitenarkiv
• Vigen, Thea; Ihle-Hansen, Håkon; Lyngbakken, Magnus; Berge, Trygve; Thommessen, Bente & Ihle-Hansen, Hege [Vis alle 12 forfattere av denne artikkelen] (2019). Blood pressure at age 40 predicts carotid atherosclerosis two decades later: Data from the Akershus Cardiac Examination 1950 Study. Journal of Hypertension. ISSN 0263-6352. 37(10), s. 1982–1990. doi: 10.1097/HJH.0000000000002131. Fulltekst i vitenarkiv
• Brynildsen, Jon; Myhre, Peder Langeland; Lyngbakken, Magnus; Klæboe, Lars Gunnar; Stridsberg, Mats & Christensen, Geir Arve [Vis alle 9 forfattere av denne artikkelen] (2019). Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis. Clinical Biochemistry. ISSN 0009-9120. 71, s. 17–23. doi: 10.1016/j.clinbiochem.2019.06.008. Fulltekst i vitenarkiv
• Lyngbakken, Magnus; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian & Omland, Torbjørn (2019). Temporal changes in cardiac troponin i are associated with risk of cardiovascular events in the general population: The Nord-Trøndelag health study. Clinical Chemistry. ISSN 0009-9147. 65(7), s. 871–881. doi: 10.1373/clinchem.2018.301069. Fulltekst i vitenarkiv
• Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Vis alle 13 forfattere av denne artikkelen] (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European Journal of Nutrition. ISSN 1436-6207. s. 1–11. doi: 10.1007/s00394-019-02007-3. Fulltekst i vitenarkiv
• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Hagberg, Guri; Engedal, Knut & Rønning, Ole M. [Vis alle 12 forfattere av denne artikkelen] (2019). Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study. Journal of Alzheimer's Disease. ISSN 1387-2877. 70(4), s. 1041–1049. doi: 10.3233/JAD-190327. Fulltekst i vitenarkiv
• Lyngbakken, Magnus; Myhre, Peder Langeland; Røsjø, Helge & Omland, Torbjørn (2019). Novel biomarkers of cardiovascular disease: Applications in clinical practice. Critical reviews in clinical laboratory sciences. ISSN 1040-8363. 56(1), s. 33–60. doi: 10.1080/10408363.2018.1525335.
• Brynildsen, Jon; Petaja, Liisa; Myhre, Peder Langeland; Lyngbakken, Magnus; Nygård, Ståle & Stridsberg, Mats [Vis alle 11 forfattere av denne artikkelen] (2019). Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study. Critical Care Medicine. ISSN 0090-3493. 47(5), s. e412–e419. doi: 10.1097/CCM.0000000000003670.
• Berge, Trygve; Lyngbakken, Magnus; Ihle-Hansen, Håkon; Brynildsen, Jon; Pervez, Mohammad Osman & Aagaard, Erika Nerdrum [Vis alle 14 forfattere av denne artikkelen] (2018). Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old general population cohort: The Akershus Cardiac Examination (ACE) 1950 Study. BMJ Open. ISSN 2044-6055. 8:e021704(7), s. 1–9. doi: 10.1136/bmjopen-2018-021704. Fulltekst i vitenarkiv
• Pervez, Mohammad Osman; Winther, Jacob Andreas; Brynildsen, Jon; Strand, Heidi; Christensen, Geir Arve & Høiseth, Arne Didrik [Vis alle 11 forfattere av denne artikkelen] (2018). Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study. Biomarkers. ISSN 1354-750X. s. 1–11. doi: 10.1080/1354750X.2018.1474258.
• Berge, Kristian; Lyngbakken, Magnus; Einvik, Gunnar; Winther, Jacob Andreas; Brynildsen, Jon & Røysland, Ragnhild [Vis alle 11 forfattere av denne artikkelen] (2018). Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study. Clinical Biochemistry. ISSN 0009-9120. 59, s. 62–68. doi: 10.1016/j.clinbiochem.2018.07.006.
• Ihle-Hansen, Håkon; Vigen, Thea; Ihle-Hansen, Hege; Rønning, Ole M.; Berge, Trygve & Thommessen, Bente [Vis alle 12 forfattere av denne artikkelen] (2018). Prevalence of carotid plaque in a 63- to 65-Year-Old Norwegian cohort from the general population: The ACE (Akershus Cardiac Examination) 1950 study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 7(10). doi: 10.1161/JAHA.118.008562. Fulltekst i vitenarkiv
• Sigurdardottir, Fjola Dogg; Lyngbakken, Magnus Nakrem; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian & Røsjø, Helge [Vis alle 7 forfattere av denne artikkelen] (2018). Relative prognostic value of cardiac troponin I and C-reactive protein in the general population (from the Nord-Trøndelag Health [HUNT] Study). American Journal of Cardiology. ISSN 0002-9149. 121(8), s. 949–955. doi: 10.1016/j.amjcard.2018.01.004. Fulltekst i vitenarkiv
• Brynildsen, Jon; Petäjä, Liisa; Pettilä, Ville; Nygård, Ståle; Vaara, Suvi T. & Linko, Rita [Vis alle 13 forfattere av denne artikkelen] (2018). The predictive value of NT-proBNP and hs-TnT for risk of death in cardiac surgical patients. Clinical Biochemistry. ISSN 0009-9120. 53, s. 65–71. doi: 10.1016/j.clinbiochem.2018.01.012.
• Lyngbakken, Magnus Nakrem; Pervez, Mohammad Osman; Brynildsen, Jon; Pedersen, Marit Holmefjord; Sølvernes, Janne & Christensen, Geir Arve [Vis alle 9 forfattere av denne artikkelen] (2018). Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study. Clinical Biochemistry. ISSN 0009-9120. 52, s. 41–47. doi: 10.1016/j.clinbiochem.2017.10.015. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem (2017). Kardialt troponin og kardiovaskulær risiko. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(19). doi: 10.4045/tidsskr.17.0592.
• Pervez, Mohammad Osman; Lyngbakken, Magnus Nakrem; Myhre, Peder Langeland; Brynildsen, Jon; Langsjøen, Eva Camilla & Høiseth, Arne Didrik [Vis alle 9 forfattere av denne artikkelen] (2017). Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study. Clinical Biochemistry. ISSN 0009-9120. 50(7-8), s. 394–400. doi: 10.1016/j.clinbiochem.2016.12.010. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem; Skranes, Julia Brox; de Lemos, JA; Nygård, Ståle; Dalen, Håvard & Hveem, Kristian [Vis alle 8 forfattere av denne artikkelen] (2016). Impact of Smoking on Circulating Cardiac Troponin I Concentrations and Cardiovascular Events in the General Population: The HUNT Study (Nord-Trøndelag Health Study). Circulation. ISSN 0009-7322. 134(24), s. 1962–1972. doi: 10.1161/CIRCULATIONAHA.116.023726. Vis sammendrag

  BACKGROUND: Both tobacco smoking and circulating cardiac troponin I (cTnI) levels are associated with the risk of acute myocardial infarction, heart failure, and cardiovascular death. However, whether cTnI levels differ according to smoking status and whether smoking modifies the prognostic relationship between cTnI and outcomes remain unclear. METHODS: Using data from a large, population-based cohort, we assessed the association between smoking and cTnI and the impact of smoking on the associations between cTnI levels and the incidence of acute myocardial infarction, heart failure, and cardiovascular death. cTnI was measured with a high-sensitivity assay in 3824 never smokers, 2341 former smokers, and 2550 current smokers participating in the prospective observational HUNT Study (Nord-Trøndelag Health Study). All subjects were free from known prior cardiovascular disease and diabetes mellitus at baseline. RESULTS: The age of the participants ranged from 19 to 94 years; 55.5% were women. Current smokers exhibited significantly lower levels of cTnI (median, 2.9 ng/L; interquartile range, 2.0-4.1 ng/L) than never smokers (3.2 ng/L; interquartile range, 2.2-4.7 ng/L; P<0.001) and former smokers (3.4 ng/L; interquartile range, 2.3-5.0 ng/L; P<0.001). This association remained significant after adjustment for potential confounders (B=-0.098; 95% confidence interval, -0.129 to -0.068). We observed an association between increasing concentrations of cTnI and clinical end points in the total study cohort (adjusted hazard ratio per log unit increase in cTnI, 1.41; 95% confidence interval, 1.29-1.54). This association was attenuated for current smokers (hazard ratio, 1.17; 95% confidence interval, 0.98-1.40) and was significantly weaker than in never/former smokers (P for interaction=0.003). Prognostic accuracy, as assessed by C statistics, was significantly lower in current smokers than in never smokers (P<0.001). In addition, cTnI provided no incremental prognostic information to the Framingham Cardiovascular Disease risk score in current smokers (P=0.08). CONCLUSIONS: Current smoking is associated with lower concentrations of cTnI, suggesting that substances in tobacco smoke may affect cardiomyocyte injury. The association between cTnI levels and cardiovascular end points is stronger in never/former smokers than in current smokers, compatible with the theory that the detrimental cardiovascular impact of current smoking is mediated via mechanisms other than subclinical myocardial injury.

• Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir; Nygård, Ståle; Dalen, Håvard & Hveem, Kristian [Vis alle 7 forfattere av denne artikkelen] (2016). Gender, High-Sensitivity Troponin I, and the Risk of Cardiovascular Events (from the Nord-Trøndelag Health Study). American Journal of Cardiology. ISSN 0002-9149. 118(6), s. 816–821. doi: 10.1016/j.amjcard.2016.06.043.
• Lyngbakken, Magnus Nakrem; Omland, Torbjørn; Nordstrand, Njord; Norseth, Jon; Hjelmesæth, Jøran & Hofsø, Dag (2015). Effect of weight loss on subclinical myocardial injury: A clinical trial comparing gastric bypass surgery and intensive lifestyle intervention. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 23(8), s. 874–880. doi: 10.1177/2047487315618796.
• Berge, Trygve; Vigen, Thea; Pervez, Mohammad Omar; Ihle-Hansen, Håkon; Lyngbakken, Magnus Nakrem & Omland, Torbjørn [Vis alle 10 forfattere av denne artikkelen] (2015). Heart and brain interactions - the Akershus Cardiac Examination (ACE) 1950 study design. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 49(6), s. 308–315. doi: 10.3109/14017431.2015.1086813.

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• Axfors, Cathrine; Schmitt, Andreas M.; Janiaud, Perrine; van’t Hooft, Janneke; Abd-Elsalam, Sherief & Abdo, Ehab F. [Vis alle 94 forfattere av denne artikkelen] (2024). Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials(Nature Communications, (2021), 12, (1), 10.1038/s41467-021-22446-z). Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-45360-6.
• Axfors, Cathrine; Schmitt, Andreas M.; Janiaud, Perrine; van’t Hooft, Janneke; Abd-Elsalam, Sherief & Abdo, Ehab F. [Vis alle 94 forfattere av denne artikkelen] (2021). Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials (Nature Communications, (2021), 12, 1, (2349), 10.1038/s41467-021-22446-z). Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-23559-1.
• Berge, Kristian; Lyngbakken, Magnus Nakrem; Omland, Torbjørn; Juliebø, Vibeke; Schirmer, Henrik & Røsjø, Helge Rørvik (2021). Ytterligere læringsmomenter fra et kardiologisk perspektiv. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(1). doi: 10.4045/tidsskr.20.1025.
• Myhre, Peder Langeland; Lyngbakken, Magnus Nakrem; Røsjø, Helge Rørvik & Omland, Torbjørn (2020). Removing stable and adding precision to chronic coronary artery disease. International Journal of Cardiology. ISSN 0167-5273. 316, s. 54–56. doi: 10.1016/j.ijcard.2020.04.063.
• Lyngbakken, Magnus; Berdal, Jan Erik; Eskesen, Arne N; Kvale, Dag; Inge Christoffer, Olsen & Rangberg, Anbjørg [Vis alle 10 forfattere av denne artikkelen] (2020). Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trial. Trials. ISSN 1745-6215. 21. doi: 10.1186/s13063-020-04420-0.
• Skranes, Julia Brox; Claggett, Brian; Myhre, Peder Langeland; Lyngbakken, Magnus Nakrem; Solomon, Scott D. & Sabatine, Marc S. [Vis alle 8 forfattere av denne artikkelen] (2019). Current Smoking Is Associated with Lower Concentrations of High-Sensitivity Cardiac Troponin T in Patients with Stable Coronary Artery Disease: The PEACE Trial. Circulation. ISSN 0009-7322. 140(24), s. 2044–2046. doi: 10.1161/CIRCULATIONAHA.119.041991.
• Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian & Omland, Torbjørn (2017). Temporal Changes in Cardiac Troponin I and Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study.
• Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian & Omland, Torbjørn (2016). Impact of smoking on circulating troponin I concentrations and cardiovascular events in the general population: The HUNT Study.
• Myhre, Peder Langeland; Lyngbakken, Magnus Nakrem & Røsjø, Helge (2015). ESC 2015: Biomarkører. Hjerteforum. ISSN 0802-1465. 28(4), s. 65–66.
• Lyngbakken, Magnus Nakrem & Røsjø, Helge (2015). AHA-kongressen 2014: Biomarkører. Hjerteforum. ISSN 0802-1465. 28(1), s. 130–131.
• Lyngbakken, Magnus Nakrem; Omland, Torbjørn; Nordstrand, Njord; Norseth, Jon; Hjelmesæth, Jøran & Hofsø, Dag (2014). Effect of weight loss on circulating high sensitivity cardiac troponin I concentrations: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention.
• Lyngbakken, Magnus Nakrem; Omland, Torbjørn; Nordstrand, Njord; Norseth, Jon; Hjelmesæth, Jøran & Hofsø, Dag (2014). Gastric Bypass Surgery is Associated with a Marked Reduction in Circulating High Sensitivity Cardiac Troponin I Concentrations: Comparison with Intensive Lifestyle Intervention.

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