Ole Jacob Nilsen

• Nilsen, Ole Jacob; Glott, Thomas; Holm, Henriette Veiby; Cruz, Célia Duarte & Frich, Lars (2026). Early intradetrusor injection of Onabotulinumtoxin A in patients with subacute spinal cord injury: The SCIBOT study. Scandinavian Journal of Urology. ISSN 2168-1805. 61, s. 188–194. doi: 10.2340/sju.v61.46428. Fulltekst i vitenarkiv
• Holm, Henriette Veiby & Nilsen, Ole Jacob (2025). Management of prostatic necrosis and the devastated bladder outlet—a narrative review. Translational Andrology and Urology. ISSN 2223-4683. 14(10), s. 3354–3366. doi: 10.21037/tau-2025-433. Fulltekst i vitenarkiv Vis sammendrag

  Background and Objective: Although devastating complications of the bladder outlet resulting from prostate cancer (PC) treatments are relatively uncommon, they do exist. These complications deteriorate patients’ quality of life (QoL), and with the combination of increased incidence of PC and patient longevity after treatment, awareness of adverse outcomes in recent years have increased. This review discusses the incidence, risk factors, diagnostic work-up, and management options for devastated bladder outlet (DBO), resulting from PC treatment complications, requiring urinary diversion (UD). Methods: A systematic literature search was conducted via OvidSP covering 1946 to present. The selection was limited to English language studies. Key Content and Findings: DBO can be a consequence of the treatment of benign conditions, but more frequently from complications of pelvic cancer treatments and especially multimodal PC treatments. Patients with a combination of complications, typically recalcitrant bladder outlet obstruction, urinary incontinence, urinary fistula, and/or severe bladder dysfunction end up in a situation we can call DBO. Initially patients will be offered conservative treatment or reconstruction. However, in the worst circumstances, such as prior radiotherapy, failed reconstruction, DBO with end-stage bladders, or patient’s severe comorbidities, reconstruction may neither be realistic nor justified. UD with or without cystectomy may be the best option for these patients. Outcomes and repercussions on QoL vary extensively with management options. Meticulous preoperative diagnostic evaluation and thorough patient counseling are paramount in selecting the right treatment strategy for each individual patient. There are a wide range of UD options including a suprapubic catheter to more sophisticated solutions like augmentation cystoplasty with continent catheterizable channel and many others. Conclusions: There is a non-negligible risk of DBO after treatment of PC, especially following multimodal treatment. In the worst circumstances, management with UD may be necessary. Possible UD options are discussed.

• Glott, Thomas; Wright, Daniel Nilsen; Nilsen, Ole Jacob; Annavini, Eis & Boulland, Jean-Luc (2025). Urodynamics with MEMS-Based pressure sensors, a clinical validation. Biosensors and Bioelectronics. ISSN 0956-5663. 278. doi: 10.1016/j.bios.2025.117320. Fulltekst i vitenarkiv Vis sammendrag

  Cystometry is a urodynamic investigation used to examine the pressure-volume relationship during bladder filling. In clinical practice, cystometry is typically performed with water or air-filled catheters connected to an external transducer. These catheters, which are primarily suited for short-duration measurements, can compromise pressure transmission due to air bubbles, clogging, bending, and movements, and they are not sensitive enough to rapid pressure fluctuations. Moreover, ensuring proper leveling of the transducer is crucial for accurate measurement. To overcome these limitations, a MEMS pressure sensor prototype was previously developed. This study now evaluates the concurrent validity and reliability of this prototype against a conventional cystometry system during a series of clinical cases involving 33 patients undergoing routine cystometry. Excluding three sensors for which a correct placement during cystometry could not be verified, 83.3% of sensors produced useful data. Among these, 88% demonstrated a strong correlation with the reference system in the time-amplitude domain and 72% exhibited a high correlation in the time-frequency domain. Although these sensors were manually assembled and did not go through a standardized manufacturing process to enhance stability and detect potential failures, over 78.8% of the 33 sensors tested remained functional after the trial. Therefore, these results support the adoption of this technology in clinical practice, as it may improve diagnostic efficiency, reduce patient discomfort, and potentially be used for long-term and ambulatory urodynamics.

• Bøe, Rebecca Therese; Nilsen, Ole Jacob & Holm, Henriette Veiby (2023). AdVance™ male sling for stress urinary incontinence: Long-term follow-up and patient satisfaction. BJUI Compass. 5(1), s. 42–51. doi: 10.1002/bco2.287. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Objectives To evaluate long‐term effects, complications and satisfaction among patients treated with AdVance™ and AdVance™ XP slings (AS) at a Norwegian specialist care hospital. Materials and Methods Patients who had an AS implanted due to stress urinary incontinence (SUI) 2009–2016 were identified retrospectively. Demographic and perioperative data were extracted from electronic patient files. We did a patient‐reported outcome measure (PROM) survey with the Expanded Prostate Cancer Index Composite (EPIC‐26) urinary domain and a Satisfaction Questionnaire (SQ) 2018–2020. Cure was defined as use of ≤1 pad/day. Results The AS was implanted in 165 patients, mainly due to mild to moderate SUI (median leakage 112 g, range 13–589 g/24 h). Preoperative urodynamics showed mild detrusor overactivity (DO) in 11 patients. At 6‐week follow‐up, 148 patients (90%) were cured. The most common complication was urinary retention ( N  = 38), transient in 32 patients (range 1–42 days). Two patients were later operated with division of the sling due to persistent retention. During clinical follow‐up of up to 12 years, 27 patients were reoperated due to persistent/recurrent incontinence. The PROM survey was sent to 125 patients and 115 (92%) replied at median 73 (20–134) months postoperatively. Ninety‐one (79%) used ≤1 pads/day, 97 (85%) were satisfied, one patient‐reported pain. Regression analyses showed that failure (>1 pad/day) was significantly associated with a higher amount of leakage preoperatively and at the 6‐week follow‐up. Total cure rate in the complete cohort was 64% at median 73 (20–134) months follow‐up. Conclusions The AS shows good and persistent long‐term results in patients with mild to moderate SUI. The only identified risk factor for long‐term failure was higher amount of leakage preoperatively. The incidence of high body mass index (BMI), DO and previous radiotherapy was low and not significantly associated with failure but is still considered risk factors.

• Nilsen, Ole Jacob; Holm, Henriette Veiby; Ekerhult, Teresa O.; Lindqvist, Klas; Grabowska, Beata & Persson, Beata [Vis alle 7 forfattere av denne artikkelen] (2022). To Transect or Not Transect: Results from the Scandinavian Urethroplasty Study, A Multicentre Randomised Study of Bulbar Urethroplasty Comparing Excision and Primary Anastomosis Versus Buccal Mucosal Grafting. European Urology. ISSN 0302-2838. 81(4), s. 375–382. doi: 10.1016/j.eururo.2021.12.017. Fulltekst i vitenarkiv Vis sammendrag

  Background Open surgical treatment of short bulbar urethral strictures (urethroplasty) is commonly performed as transecting excision and primary anastomosis (tEPA) or buccal mucosa grafting (BMG). Erectile dysfunction and penile complications have been reported, but there is an absence of randomised trials. Objective To evaluate sexual dysfunction and penile complications after urethroplasty with tEPA versus BMG. Design, setting, and participants Centres in Finland, Sweden and Norway participated. Patients with a bulbar urethral stricture of ≤2 cm without previous urethroplasty were randomised. The primary endpoints were the degree of erectile dysfunction and penile complications. Follow-up was 12 mo. Intervention Patients were randomised to either tEPA or BMG urethroplasty. Outcome measurements and statistical analysis Sexual dysfunction was measured using the International Index of Erectile Function, 5-item version (IIEF-5) and a penile complications questionnaire (PCQ) designed for this study. Continuous data were analysed using analysis of covariance and categorical data were compared using a χ2 test. Results and limitations A total of 151 patients were randomised to either tEPA (n = 75) or BMG (n = 76). The tEPA group reported more penile complications (p = 0.02), especially reduced glans filling (p = 0.03) and a shortened penis (p = 0.001). There were no differences in postoperative IIEF-5 total scores. Recurrence rates were similar in both groups (12.9%) but the study was not designed to detect differences in recurrence rates. The PCQ is not validated, which is a limitation. Conclusions More patients reported penile complications after urethroplasty with tEPA than with BMG. This should be considered when choosing the operative method, and patients should be informed accordingly. Patient summary This study compared two common operations for repair of narrowing of the male urethra. Neither of the two methods seems to cause worsened erections. However, penile problems are more common after the transection technique than after the grafting technique.

• Beiske, Marius J.; Holm, Henriette Veiby & Nilsen, Ole Jacob (2021). A comparison of urethral catheterization duration - three weeks versus two weeks after bulbar urethroplasty. Scandinavian Journal of Urology. ISSN 2168-1805. 55(4), s. 313–316. doi: 10.1080/21681805.2021.1945141. Fulltekst i vitenarkiv

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• Holm, Henriette Veiby; Ohnesorge, Susanne Sylvia & Nilsen, Ole Jacob (2026). Long-term Outcomes of Transecting Versus Nontransecting Bulbar Urethroplasty: Results from the Scandinavian Urethroplasty Study. European Urology Focus. doi: 10.1016/j.euf.2026.05.007. Fulltekst i vitenarkiv

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