Yvonne Böttcher

Bilde av Yvonne Böttcher
English version of this page
Telefon +47 67963910
Mobiltelefon 67963928
Brukernavn
Besøksadresse Sykehusveien 25 None 1474 NORDBYHAGEN
Postadresse Akershus universitetssykehus 1478 LØRENSKOG

Obesity is one of the major healthcare challenges worldwide and elucidation of genetic susceptibility variants has been exploded during last years. Common variants have been confirmed for many different genomic loci via genome-wide association studies and meta-analyses. Still the effect sizes are low and represent only part of the overall heritability of polygenic obesity. Our research group is interested in (i) genetic variation underlying human eating behavior and (ii) in epigenetic mechanisms in different human adipose tissue depots. We hope to better understand the “missing heritability” of obesity.

The main team of our group is based at University of Oslo and Akershus University Hospital in Norway (UiO). Another team is working at the University of Leipzig, IFB AdiposityDiseases, Germany (Uni Leipzig).

You can find more information on our homepage (www.adilabs.wordpress.com).

 

Curriculum Vitae Yvonne Böttcher

EDUCATION & TRAINING

05/2015           HABILITATION in “Experimental Medicine”

01/01-01/05     PhD in Biology, Faculty of Medicine and Faculty of Biological Sciences, Pharmacy and Psychology, Department of Endocrinology, University of Leipzig, Germany

10/01-05/02     Guest research fellow at Max-Delbrück-Center for Molecular Medicine (MDC), Department of Gene Mapping, Berlin-Buch, Germany

09/2000           Diploma/Master of Science in Biology (thesis in genetics)

 

CURRENT POSITION

05/16-ongoing Full Professor of Molecular Medicine and head of research group, Medical Faculty, Institute of Clinical Medicine, Department of Clinical Molecular Biology, University of Oslo, Norway
 

05/16-ongoing Research Professor at Akershus University Hospital, EPIGEN lab, Lørenskog, Norway
 

PREVIOUS POSITIONS

2011-2016       Junior research group leader/senior researcher “Functional Genetics of Obesity” IFB AdiposityDiseases, University of Leipzig, Germany

10/09-07/10     Maternity leave

06/08-08/09     Postdoc training at deCODE genetics in the frame work of a Marie Curie Program, CNS Department, Reykjavík, Iceland

01/05-06/08     Postdoc Medical Faculty, University of Leipzig, Germany (two year scholarship from the prestigious Peter and Traudl Engelhorn Foundation);

09/04-01/05     Maternity leave

 

FELLOWSHIPS, PRIZES & AWARDS

2013                EFSD/Lilly Research Fellowship 50.000€

2008-2010       Postdoctoral research fellowship (2 year full salary) highly competitive for top young researchers; planned 2 year stay at Wellcome Trust Center for Human Genetics, Oxford, UK

2006-2008       Postdoctoral research fellowship (2 year full salary; ~115.200€)

2006                Hans-Christian-Hagedorn-Prize 9.000€

2006                Best Research Poster Prize, Research Festival, University of Leipzig, Germany

2006                formel.1 research grant (50.000€)

 

FUNDING BODY

I have attracted external funding of 2.29 Mio EURO in total

2019 Norwegian Regional Research Funding: HelseSør-Øst (Utenlandsstipend Postdoc): 118.000 NOK=~12.164€

2018-2020 Norwegian Regional Research Funding: HelseSør-Øst (Postdoc): 3.201.000 NOK=~354.878€

2017-2019 Norwegian Regional Research Funding: HelseSør-Øst (Postdoc):3.117.000 NOK=~345.183€

2015-2020 German Ministry of Health/Education, IFB AdiposityDiseases (research grant): 221.869€

2015-2020 German Ministry of Health/Education, IFB AdiposityDiseases (research grant): 335.320€

2013 EFSD Lilly Fellowship (research grant): 50.000€

2012-2014 German Research Foundation (research grant): 71.900€

2012-2015 German Ministry of Health/Education, IFB AdiposityDiseases (research grant): 152.560 €

2011-2015 German Ministry of Health/Education, IFB AdiposityDiseases (research grant): 278.000 €

2011-2013 German Ministry of Health/Education, IFB AdiposityDiseases (research grant): 138.880 €

2011-2014 German Ministry of Health/Education, IFB AdiposityDiseases (research grant): 150.560 €

2008-2010 German Research Foundation (research fellowship): 42.000€

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2011-ongoing Member of the European Association for the Study of Diabetes (EASD)

2015-2016      Member of the European Society for Human Genetics (ESHG)

2016-ongoing Member of Norwegian Obesity Research Association (NFFF)

2018-ongoing  Member of the Nordic Society for Precision Medicine (NSPM)

 

Publikasjoner

Original articles (selected last 5 years):

Rohde K, Keller M, la Cour Poulesn L, Rønningen T, Stumvoll M, Tönjes A, Kovacs P, Horstmann A, Villringer A, Blüher M, Böttcher Y. (Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution. EBioMedicine. 2019 Jun; 44:476-488. doi: 10.1016/j.ebiom.2019.05.050.

Rohde K, Keller M, la Cour Poulsen L, Blüher M, Kovacs P, Böttcher Y. Genetics and epigenetics in obesity. Metabolism. 2018 Nov 3. pii: S0026-0495(18)30225-7. doi: 10.1016/j.metabol.2018.10.007. [Epub ahead of print]

Keller M, Klös M, Rohde K, Krüger J, Kurze T, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Stumvoll M, Blüher M, Kovacs P, Böttcher Y. DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism. FASEB J. 2018 doi: 10.1096/fj.201800528R. [Epub ahead of print]

Rohde K, Klös M, Hopp L, Liu X, Keller M, Stumvoll M, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Kovacs P, Binder H, Blüher M, Böttcher Y. IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits. Sci Rep. 2017 Sep 28;7(1):12369. doi: 10.1038/s41598-017-12393-5.

Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, (multiple coauthors), Böttcher Y, (multiple coauthors), Guo X, Roberts DJ, Florez JC, Sladek R, Dupuis J, Morris AP, Tai ES, Selvin E, Rotter JI, Langenberg C, Barroso I, Meigs JB. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383.

Haertle L, Maierhofer A, Böck J, Lehnen H, Böttcher Y, Blüher M, Schorsch M, Potabattula R, El Hajj N, Appenzeller S, Haaf T. Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals. PLoS One. 2017 Aug 30;12(8):e0184030. doi: 10.1371/journal.pone.0184030.

Löffler A, Luck T, Then FS, Luck-Sikorski C, Pabst A, Kovacs P, Böttcher Y, Breitfeld J, Tönjes A, Horstmann A, Löffler M, Engel C, Thiery J, Villringer A, Stumvoll M, Riedel-Heller SG. Effects of psychological eating behaviour domains on the association between socio-economic status and BMI. Public Health Nutr. 2017 Jul 24:1-7. doi: 10.1017/S1368980017001653.

Drabe M, Rullmann M, Luthardt J, Boettcher Y, Regenthal R, Ploetz T, Becker GA, Patt M, Schinke C, Bergh FT, Zientek F, Hilbert A, Bresch A, Fenske W, Hankir MK, Sabri O, Hesse S. Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity. Transl Psychiatry. 2017 Jul 4;7(7):e1167. doi: 10.1038/tp.2017.133.

Weiner J, Rohde K, Krause K, Zieger K, Klöting N, Kralisch S, Kovacs P, Stumvoll M, Blüher M, Böttcher Y, Heiker JT. Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation. Mol Metab. 2017 Mar 28;6(6):482-493. doi: 10.1016/j.molmet.2017.03.004. eCollection 2017 Jun. 

Blüher S, Käpplinger J, Herget S, Reichardt S, Böttcher Y, Grimm A, Kratzsch J, Petroff D. Cardiometabolic risk markers, adipocyte fatty acid binding protein (aFABP) and the impact of high-intensity interval training (HIIT) in obese adolescents. Metabolism. 2017 Mar;68:77-87. doi: 10.1016/j.metabol.2016.11.015.

Keller M, Hopp L, Liu X, Wohland T, Rohde K, Cancello R, Klös M, Bacos K, Kern M, Eichelmann F, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Stumvoll M, Kovacs P, DiBlasio AM, Ling C, Binder H, Blüher M, Böttcher Y. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity. Mol Metab. 2016 Nov 16;6(1):86-100. doi: 10.1016/j.molmet.2016.11.003. eCollection 2017 Jan.

Pfeiffer S, Krüger J, Maierhofer A, Böttcher Y, Klöting N, El Hajj N, Schleinitz D, Schön MR, Dietrich A, Fasshauer M, Lohmann T, Dreßler M, Stumvoll M, Haaf T, Blüher M, Kovacs P. Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction. Sci Rep. 2016 Jun 27;6:27969. doi: 10.1038/srep27969.

Lu Y, Day FR, (multiple co-authors), Boettcher Y, (multiple co-authors), Hirschhorn JN, Pospisilik JA, Zillikens MC, Lindgren C, Kilpeläinen TO, Loos RJ. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun. 2016 Feb 1;7:10495. doi: 10.1038/ncomms10495.

Voisin S, Almén MS, Zheleznyakova GY, Lundberg L, Zarei S, Castillo S, Eriksson FE, Nilsson EK, Blüher M, Böttcher Y, Kovacs P, Klovins J, Rask-Andersen M, Schiöth HB. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers. Genome Med. 2015 Oct 8;7(1):103. doi: 10.1186/s13073-015-0225-4

Rohde K, Keller M, Stumvoll M, Dietrich A, Blüher M, Böttcher Y. DNA 5-Hydroxymethylation in human adipose tissue differs between subcutaneous and visceral adipose tissue depots. Epigenomics. 2015;7(6):911-20. doi: 10.2217/epi.15.50.

Löffler A, Luck T, Then FS, Luppa M, Sikorski C, Kovacs P, Tönjes A, Böttcher Y, Breitfeld J, Horstmann A, Löffler M, Engel C, Thiery J, Stumvoll M, Riedel-Heller SG. Age- and gender-specific norms for the German version of the Three-Factor Eating-Questionnaire (TFEQ). Appetite. 2015 Apr 15;91:241-247. doi: 10.1016/j.appet.2015.04.044. [Epub ahead of print]

Löffler A, Luck T, Then FS, Sikorski C, Kovacs P, Böttcher Y, Breitfeld J, Tönjes A, Horstmann A, Löffler M, Engel C, Thiery J, Villringer A, Stumvoll M, Riedel-Heller SG. Eating Behaviour in the General Population: An Analysis of the Factor Structure of the German Version of the Three-Factor-Eating-Questionnaire (TFEQ) and Its Association with the Body Mass Index. PLoS One. 2015 Jul 31;10(7):e0133977. doi: 10.1371/journal.pone.0133977

Rohde K, Federbusch M, Horstmann A, Keller M, Villringer A, Stumvoll M, Tönjes A, Kovacs P, Böttcher Y. Genetic variants in AKR1B10 associate with human eating behavior. BMC Genet. 2015 Mar 25;16:31. doi: 10.1186/s12863-015-0189-9.

Liu X, Hinney A, Scholz M, Scherag A, Tönjes A, Stumvoll M, Stadler PF, Hebebrand J, Böttcher Y. Indications for potential parent-of-origin effects within the FTO gene. PLoS One. 2015 Mar 20;10(3):e0119206. doi: 10.1371/journal.pone.0119206. eCollection 2015.

Locke AE, (multiple co-authors), Böttcher Y, (multiple co-authors), Speliotes EK. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177.

Shungin D, (multiple co-authors), Böttcher Y, (multiple co-authors), Mohlke KL. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-96. doi: 10.1038/nature14132.

Liu X, Weidle K, Schröck K, Tönjes A, Schleinitz D, Breitfeld J, Stumvoll M, Böttcher Y, Schöneberg T, Kovacs P. Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations. PLoS One. 2015 Feb 3;10(2):e0117093. doi: 10.1371/journal.pone.0117093. eCollection 2015.

Rohde K, Keller M, Horstmann A, Liu X, Eichelmann F, Stumvoll M, Villringer A, Kovacs P, Tönjes A, Böttcher Y. Role of genetic variants in ADIPOQ in human eating behavior. Genes Nutr. 2015 Jan;10(1):449. doi: 10.1007/s12263-014-0449-8.

Keller M, Kralisch S, Rohde K, Schleinitz D, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Tönjes A, Stumvoll M, Kovacs P, Fasshauer M, Blüher M, Böttcher Y. Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis. Diabetologia. 2014 Nov;57(11):2374-83. doi: 10.1007/s00125-014-3356-z.

Breitfeld J, Sandvoss R, Schleinitz D, Böttcher Y, Fasshauer M, Blüher M, Stumvoll M, Kovacs P, Wittenburg H, Tönjes A. Serum adiponectin and progranulin levels are associated with gallstone disease. Exp Clin Endocrinol Diabetes. 2014 Nov;122(10):559-63. doi: 10.1055/s-0034-1376969.

Rohde K, Keller M, Klös M, Schleinitz D, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Stumvoll M, Kovacs P, Blüher M, Böttcher Y. Adipose tissue depot specific promoter methylation of TMEM18. J Mol Med (Berl). 2014 Aug;92(8):881-8. doi: 10.1007/s00109-014-1154-1.

Gast MT, Tönjes A, Keller M, Horstmann A, Steinle N, Scholz M, Müller I, Villringer A, Stumvoll M, Kovacs P, Böttcher Y. The role of rs2237781 within GRM8 in eating behavior. Brain Behav. 2013 Sep;3(5):495-502. doi: 10.1002/brb3.151.

Keller M, Liu X, Wohland T, Rohde K, Gast MT, Stumvoll M, Kovacs P, Tönjes A, Böttcher Y. TAS2R38 and its influence on smoking behavior and glucose homeostasis in the German Sorbs. PLoS One. 2013 Dec 2;8(12):e80512. doi: 10.1371/journal.pone.0080512. eCollection 2013.

Horstmann A, Kovacs P, Kabisch S, Boettcher Y, Schloegl H, Tönjes A, Stumvoll M, Pleger B, Villringer A. Common genetic variation near MC4R has a sex-specific impact on human brain structure and eating behavior. PLoS One. 2013 Sep 16;8(9):e74362. doi: 10.1371/journal.pone.0074362. eCollection 2013.

Keller M, Schleinitz D, Förster J, Tönjes A, Böttcher Y, Fischer-Rosinsky A, Breitfeld J, Weidle K, Rayner NW, Burkhardt R, Enigk B, Müller I, Halbritter J, Koriath M, Pfeiffer A, Krohn K, Groop L, Spranger J, Stumvoll M, Kovacs P. THOC5: a novel gene involved in HDL-cholesterol metabolism. J Lipid Res. 2013 Nov;54(11):3170-6. doi: 10.1194/jlr.M039420.

Breitfeld J, Heiker JT, Böttcher Y, Schleinitz D, Tönjes A, Weidle K, Krause K, Kuettner EB, Scholz M, Kiess W, Sträter N, Beck-Sickinger AG, Stumvoll M, Körner A, Blüher M, Kovacs P. Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels. J Mol Med (Berl). 2013 Nov;91(11):1285-92. doi: 10.1007/s00109-013-1062-9.

Breitfeld J, Tönjes A, Gast MT, Schleinitz D, Blüher M, Stumvoll M, Kovacs P, Böttcher Y. Role of vaspin in human eating behaviour. PLoS One. 2013;8(1):e54140. doi: 10.1371/journal.pone.0054140.

Manning AK, (multiple co-authors), Böttcher Y, (multiple co-authors), Langenberg C. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012 May 13;44(6):659-69. doi: 10.1038/ng.2274.

  • Rohde, Kerstin; Keller, Maria; La Cour Poulsen, Lars; Rønningen, Torunn; Stumvoll, Michael; Tonjes, Anke; Kovacs, Peter; Horstmann, Annette; Villringer, Arno; Bluher, Matthias & Böttcher, Yvonne (2019). (Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution. EBioMedicine.  ISSN 2352-3964.  44, s 476- 488 . doi: 10.1016/j.ebiom.2019.05.050 Fulltekst i vitenarkiv.
  • Keller, Maria; Klos, Matthias; Rohde, Kerstin; Krüger, Jacqueline; Kurze, Tabea; Dietrich, Arne; Schön, Michael R.; Gärtner, Daniel; Lohmann, Tobias; Dressler, Miriam; Stumvoll, Michael; Bluher, Matthias; Kovacs, Peter & Böttcher, Yvonne (2018). DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism.. The FASEB Journal.  ISSN 0892-6638.  32(12), s 6898- 6910 . doi: 10.1096/fj.201800528R Fulltekst i vitenarkiv.
  • Rohde, Kerstin; Keller, Maria; La Cour Poulsen, Lars; Blüher, Matthias; Kovacs, Peter & Böttcher, Yvonne (2018). Genetics and epigenetics in obesity. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  92, s 37- 50 . doi: 10.1016/j.metabol.2018.10.007 Fulltekst i vitenarkiv.
  • Blüher, Susann; Käpplinger, Jakob; Herget, Sabine; Reichardt, Sandra; Böttcher, Yvonne; Grimm, Andrea; Kratzsch, Jürgen & Petroff, David (2017). Cardiometabolic risk markers, adipocyte fatty acid binding protein (aFABP) and the impact of high-intensity interval training (HIIT) in obese adolescents. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  68, s 77- 87 . doi: 10.1016/j.metabol.2016.11.015
  • Drabe, Mandy; Rullmann, Michael; Luthardt, Julia; Böttcher, Yvonne; Regenthal, Ralf; Plötz, Tanja; Becker, Georg Alexander; Patt, Marianne; Schinke, Christian; Bergh, Florian Tenh; Zientek, Franziska; Hilbert, Anja; Bresch, Anke; Fenske, Wiebke Kristin; Hankir, Mohammed Khair; Sabri, Osama & Hesse, Swen L. (2017). Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity. Translational psychiatry.  ISSN 2158-3188.  7:e1167(7), s 1- 7 . doi: 10.1038/tp.2017.133 Fulltekst i vitenarkiv.
  • Haertle, Larissa; Maierhofer, Anna; Bock, Julia; Lehnen, Harald; Böttcher, Yvonne; Blüher, Matthias; Schorsch, Martin; Potabattula, Ramya; El Hajj, Nady; Appenzeller, Silke & Haaf, Thomas (2017). Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals. PLOS ONE.  ISSN 1932-6203.  12(8) . doi: 10.1371/journal.pone.0184030 Fulltekst i vitenarkiv.
  • Loffler, Antje; Luck, Tobias; Then, Francisca S; Luck-Sikorski, Claudia; Pabst, Alexander; Kovacs, Peter; Böttcher, Yvonne; Breitfeld, Jana; Tönjes, Anke; Horstmann, Annette; Löffler, Markus; Engel, Christoph; Thiery, Joachim; Villringer, Arno; Stumvoll, Michael & Riedel-Heller, Steffi G (2017). Effects of psychological eating behaviour domains on the association between socio-economic status and BMI. Public Health Nutrition.  ISSN 1368-9800.  20(15), s 2706- 2712 . doi: 10.1017/S1368980017001653 Fulltekst i vitenarkiv.
  • Rohde, Kerstin; Klos, Matthias; Hopp, Lydia; Liu, Xuanshi; Keller, Maria; Stumvoll, Michael; Dietrich, Arne; Schön, Michael R.; Gärtner, Daniel; Lohmann, Tobias; Dreßler, Miriam; Kovacs, Peter; Binder, Hans; Blüher, Matthias & Böttcher, Yvonne (2017). IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits. Scientific Reports.  ISSN 2045-2322.  7:12369, s 1- 10 . doi: 10.1038/s41598-017-12393-5 Fulltekst i vitenarkiv.
  • Weiner, Juliane; Rohde, Kerstin; Krause, Kerstin; Zieger, Konstanze; Klöting, Nora; Kralisch, Susan; Kovacs, Peter; Stumvoll, Michael; Bluher, Matthias; Böttcher, Yvonne & Heiker, John T (2017). Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation. Molecular Metabolism.  ISSN 2212-8778.  6(6), s 482- 493 . doi: 10.1016/j.molmet.2017.03.004 Fulltekst i vitenarkiv.
  • Wheeler, Eleanor; Leong, Aaron; Liu, Ching-Ti; Hivert, Marie-France; Strawbridge, Rona J.; Podmore, Clara; Li, Man; Yao, Jie; Sim, Xueling; Hong, Jaeyoung; Chu, Audrey Y.; Zhang, Weihua; Wang, Xu; Chen, Peng; Maruthur, Nisa M.; Porneala, Bianca C.; Sharp, Stephen J.; Jia, Yucheng; Kabagambe, Edmond Kato; Chang, Li-Ching; Chen, Wei-Min; Elks, Cathy E.; Evans, Daniel S.; Fan, Qiao; Giulianini, Franco; Go, Min Jin; Hottenga, Jouke-Jan; Hu, Yao; Jackson, Anne U.; Kanoni, Stavroula; Kim, Young Jin; Kleber, Marcus E.; Ladenvall, Claes; Lecoeur, Cecile; Lim, Sing-Hui; Lu, Yingchang; Mahajan, Anubha; Marzi, Carola; Nalls, Mike A.; Navarro, Pau; Nolte, Ilja M.; Rose, Lynda M.; Rybin, Denis V.; Sanna, Serena; Shi, Yuan; Stram, Daniel O.; Takeuchi, Fumihiko; Tan, Shu Pei; van der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Wong, Andrew; Yengo, Loic; Zhao, Wanting; Goel, Anuj; Martinez Larrad, Maria Teresa; Radke, Dörte; Salo, Perttu; Tanaka, Toshiko; van Iperen, Erik P.A.; Abecasis, Goncalo; Afaq, Saima; Alizadeh, Behrooz Z.; Bertoni, Alain G.; Bonnefond, Amelie; Böttcher, Yvonne; Bottinger, Erwin P.; Campbell, Harry; Carlson, Olga D.; Chen, Chien-Hsiun; Cho, Yoon Shin; Garvey, W. Timothy; Gieger, Christian; Goodarzi, Mark O.; Grallert, Harald; Hamsten, Anders; Hartman, Catharina A.; Herder, Christian; Hsiung, Chao Agnes; Huang, Jie; Igase, Michiya; Isono, Masato; Katsuya, Tomohiro; Khor, Chiea-Chuen; Kiess, Wieland; Kohara, Katsuhiko; Kovacs, Peter; Lee, Juyoung; Lee, Wen-Jane; Lehne, Benjamin; Li, Huaixing; Liu, Jianjun; Lobbens, Stephane; Luan, Jian'an; Lyssenko, Valeriya; Meitinger, Thomas; Miki, Tetsuro; Miljkovic, Iva; Moon, Sanghoon; Mulas, Antonella; Müller, Gabriele; Müller-Nurasyid, Martina; Nagaraja, Ramaiah; Nauck, Matthias; Pankow, James S.; Polasek, Ozren; Prokopenko, Inga; Ramos, Paula S.; Rasmussen-Torvik, Laura; Rathmann, Wolfgang; Rich, Stephen S.; Robertson, Neil R.; Roden, Michael; Roussel, Ronan; Rudan, Igor; Scott, Robert A.; Scott, William R.; Sennblad, Bengt; Siscovick, David S.; Strauch, Konstantin; Sun, Liang; Swertz, Morris; Tajuddin, Salman M.; Taylor, Kent D.; Teo, Yik-Ying; Tham, Yih Chung; Tönjes, Anke; Wareham, Nicholas J.; Willemsen, Gonneke; Wilsgaard, Tom; Hingorani, Aroon D.; Egan, Josephine; Ferrucci, Luigi; Hovingh, G. Kees; Jula, Antti; Kivimäki, Mika; Kumari, Meena; Njølstad, Inger; Palmer, Colin N.A.; Serrano Rios, Manuel; Stumvoll, Michael; Watkins, Hugh; Aung, Tin; Blüher, Matthias; Boehnke, Michael; Boomsma, Dorret I.; Bornstein, Stefan R.; Chambers, John C.; Chasman, Daniel I.; Chen, Yii-Der Ida; Chen, Yduan-Tsong; Cheng, Ching-Yu; Cucca, Francesco; de Geus, Eco J.C.; Deloukas, Panos; Evans, Michele K.; Fornage, Myriam; Friedlander, Yechiel; Froguel, Philippe; Groop, Leif; Gross, Myron D.; Harris, Tamara B.; Hayward, Caroline; Heng, Chew-Kiat; Ingelsson, Erik; Kato, Norihiro; Kim, Bong-Jo; Koh, Woon-Puay; Kooner, Jaspal S.; Korner, Antje; Kuh, Diana; Kuusisto, Johanna; Laakso, Markku; Lin, Xu; Liu, Yongmei; Loos, Ruth J.F.; Magnusson, Patrik K.E.; März, Winfried; McCarthy, Mark I.; Oldehinkel, Albertine J.; Ong, Ken K.; Pedersen, Nancy L.; Pereira, Mark A.; Peters, Annette; Ridker, Paul M.; Sabanayagam, Charumathi; Sale, Michele; Saleheen, Danish; Saltevo, Juha; Schwarz, Peter E.H.; Sheu, Wayne H.-H.; Snieder, Harold; Spector, Timothy D.; Tabara, Yasuharu; Tuomilehto, Jaakko; Van Dam, Rob M.; Wilson, James G; Wilson, James F.; Wolffenbuttel, Bruce H.R.; Wong, Tien Yin; Wu, Jer-Yuarn; Yuan, Jian-Min; Zonderman, Alan B.; Soranzo, Nicole; Guo, Xiuqing; Roberts, David J; Florez, Jose C.; Sladek, Robert; Dupuis, Josée; Morris, Andrew P.; Tai, E-Shyong; Selvin, Elizabeth; Rotter, Jerome I.; Langenberg, Claudia; Barroso, Inês & Meigs, James B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Medicine.  ISSN 1549-1277. . doi: 10.1371/journal.pmed.1002383 Fulltekst i vitenarkiv.

Se alle arbeider i Cristin

Publisert 13. mai 2016 11:55 - Sist endret 8. okt. 2019 09:54