Arne Klungland

Professor II - Seksjon for Biokjemi
Bilde av Arne Klungland
English version of this page
Telefon +47-23074072
Mobiltelefon +47-47840305
Faks +47-23074061
Rom A3.3021
Brukernavn
Besøksadresse OUS Rikshospitalet bygg A 3. etasje
Postadresse Postboks 1112 Blindern 0317 OSLO

Faglige interesser

Epigenetikk, embryoutvikling, RNA, histonmodifikasjoner, DNA reparasjon.

Se også forskningsgruppens websider ved OUS.

Undervisning

PhD emne MF9225 - "A molecular approach to genetic and epigenetic gene regulation, from basic research to the clinic."

Bakgrunn

2016 - d.d. Seksjonsleder ved Forskningsseksjonen, Avdeling for mikrobiologi, Klinikk for laboratoriemedisin, Oslo Universitetssykehus

2013 - d.d. Professor II ved Seksjon for biokjemi, Avdeling for molekylærmedisin, Institutt for medisinske basalfag

2001 - 2016 Forsker ved Forskningsseksjonen, Avdeling for mikrobiologi, Klinikk for laboratoriemedisin, Oslo Universitetssykehus

2005 - 2013 Professor I ved Seksjon for biokjemi, Avdeling for molekylærmedisin, Institutt for medisinske basalfag

Verv

2012 - d.d. Medlem av Fagrådet for komparativ medisin, OSS, Oslo Universitetssykehus

 

Emneord: epigenetikk, embryoutvikling, RNA, histonmodifikasjoner, DNA reparasjon

Publikasjoner

  • Aas, Aleksander; Isakson, Pauline; Bindesbøll, Christian; Alemu, Endalkachew Ashenafi; Klungland, Arne & Simonsen, Anne (2017). Nucleocytoplasmic shuttling of FTO does not affect starvation-induced autophagy. PLoS ONE.  ISSN 1932-6203.  12:e0168182(3), s 1- 15 . doi: 10.1371/journal.pone.0168182
  • Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Robertson, Joseph; Klungland, Arne & Enserink, Jorrit (2017). TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  114(5), s 1039- 1044 . doi: 10.1073/pnas.1615093114
  • Kalikstad, Betty; Kultima, Hanna Goransson; Andersstuen, Terese; Klungland, Arne & Isaksson, Anders (2017). Gene expression profiles in preterm infants on continuous long-term oxygen therapy suggest reduced oxidative stress-dependent signaling during hypoxia. Molecular Medicine Reports.  ISSN 1791-2997.  15(4), s 1513- 1526 . doi: 10.3892/mmr.2017.6185
  • Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar & Finsen, Alexandra (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports.  ISSN 2211-1247.  18, s 82- 92 . doi: 10.1016/j.celrep.2016.12.009
  • Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne; Andersen, Jill Mari; Slupphaug, Geir; Klungland, Arne; Nilsen, Hilde & Bjørås, Magnar (2017). No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice . Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-04472-4 Fulltekst i vitenarkiv
  • Klungland, Arne & Robertson, Adam Brian (2016). Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine. Free Radical Biology & Medicine.  ISSN 0891-5849.  107, s 62- 68 . doi: 10.1016/j.freeradbiomed.2016.11.038
  • Alemu, Endalkachew Ashenafi; He, Chuan & Klungland, Arne (2016). ALKBHs-facilitated RNA modifications and de-modifications. DNA Repair.  ISSN 1568-7864.  44, s 87- 91 . doi: 10.1016/j.dnarep.2016.05.026
  • Dahl, John Arne; Jung, Inkyung; Aanes, Håvard; Greggains, Gareth; Manaf, Adeel; Lerdrup, Mads; Li, Guoqiang; Kuan, Samantha; Li, Bin; Lee, Ah Young; Preissl, Sebastian; Jermstad, Ingunn; Haugen, Mads Haugland; Suganthan, Rajikala; Bjørås, Magnar; Hansen, Klaus; Dalen, Knut Tomas; Fedorcsák, Péter; Ren, Bing & Klungland, Arne (2016). Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature.  ISSN 0028-0836.  537(7621), s 548- 552 . doi: 10.1038/nature19360
  • Klungland, Arne; Dahl, John Arne; Greggains, Gareth; Fedorcsák, Péter & Filipczyk, Adam (2016). Reversible RNA modifications in meiosis and pluripotency. Nature Methods.  ISSN 1548-7091.  14(1), s 18- 22 . doi: 10.1038/nmeth.4111
  • Landfors, Miriam; Nakken, Sigve; Fusser, Markus; Dahl, John Arne; Klungland, Arne & Fedorcsák, Péter (2016). Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations. Fertility and Sterility.  ISSN 0015-0282.  105(5), s 1170- 1179e5 . doi: 10.1016/j.fertnstert.2016.01.002
  • Lauritzen, Knut Husø; Hasan-Olive, Md Mahdi; Regnell, Christine E; Kleppa, Liv; Scheibye Knudsen, Morten; Gjedde, Albert; Klungland, Arne; Bohr, Vilhelm A; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiology of Aging.  ISSN 0197-4580.  48, s 34- 47 . doi: 10.1016/j.neurobiolaging.2016.08.005
  • Liu, Fange; Clark, Wesley; Luo, Guanzheng; Wang, Xiaoyun; Fu, Ye; Wei, Jiangbo; Wang, Xiao; Hao, Ziyang; Dai, Qing; Zheng, Guanqun; Ma, Honghui; Han, Dali; Evans, Molly; Klungland, Arne; Pan, Tao & He, Chuan (2016). ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell.  ISSN 0092-8674.  167(3), s 816- 828 . doi: 10.1016/j.cell.2016.09.038
  • Mi, Shuangli; Klungland, Arne & Yang, Yun-Gui (2016). Base-excision repair and beyond —A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015. Science China Life Sciences.  ISSN 1674-7305.  59(1), s 89- 92 . doi: 10.1007/s11427-015-4983-4
  • Møllersen, Linda; Moldestad, Olve; Rowe, Alexander D.; Bjølgerud, Anja; Holm, Ingunn; Tveterås, Linda Augustin; Klungland, Arne & Retterstøl, Lars (2016). Effects of anthocyanins on CAG repeat instability and behaviour in Huntington's disease R6/1 mice . PLOS Currents.  ISSN 2157-3999.  8(HuntingtonDisease, 2016)
  • Ougland, Rune; Jonson, Ida; Moen, Marivi Nabong; Nesse, Gaute; Asker, Gry; Klungland, Arne & Larsen, Elisabeth (2016). Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells. Cellular Physiology and Biochemistry.  ISSN 1015-8987.  38(1), s 173- 184 . doi: 10.1159/000438619
  • Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang & Dahl, John Arne (2016). DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates. Biochemistry and Biophysics Reports.  ISSN 2405-5808.  6, s 9- 15 . doi: 10.1016/j.bbrep.2016.02.011
  • Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine Broberg; Lyle, Robert; Kringen, Marianne K.; Staff, Anne Cathrine; Dybedal, Ingunn; Mills, Ian Geoffrey; Klungland, Arne & Staerk, Judith (2016). Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics & Chromatin.  ISSN 1756-8935.  9 . doi: 10.1186/s13072-016-0070-8
  • Vindedal, Gry Fluge; Thoren, Anna; Jensen, Vidar; Klungland, Arne; Zhang, Yong; Holtzman, Michael; Ottersen, Ole Petter & Nagelhus, Erlend Arnulf (2016). Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Molecular and Cellular Neuroscience.  ISSN 1044-7431.  77, s 47- 52 . doi: 10.1016/j.mcn.2016.10.004
  • Weber, Alain R.; Krawczyk, Claudia; Robertson, Adam Brian; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Schürmann, David; Klungland, Arne & Schär, Primo (2016). Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nature Communications.  ISSN 2041-1723.  7 . doi: 10.1038/ncomms10806
  • Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne & Bjørås, Magnar (2015). Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports.  ISSN 2211-1247.  13(12), s 2671- 2678 . doi: 10.1016/j.celrep.2015.12.001 Fulltekst i vitenarkiv
  • Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Koehler, Christian; Thiede, Bernd; Lorenz, Susanne; Meza, Leonardo Zepeda; Klungland, Arne & Enserink, Jorrit (2015). Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes. Genome Research.  ISSN 1088-9051.  25(6), s 897- 906 . doi: 10.1101/gr.185793.114
  • Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål & Klungland, Arne (2015). Lysine methylation of the valosin-containing protein (VCP) is dispensable for development and survival of mice. PLoS ONE.  ISSN 1932-6203.  10(11) . doi: 10.1371/journal.pone.0141472 Fulltekst i vitenarkiv
  • Ke, Shengdong; Alemu, Endalkachew Ashenafi; Mertens, Claudia; Gantman, Emily Conn; Fak, John J.; Mele, Aldo; Haripal, Bhagwattie; Zucker-Scharff, Ilana; Moore, Michael J.; Park, Christopher Y.; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Klungland, Arne; Darnell, James E. & Darnell, Robert B. (2015). A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes & Development.  ISSN 0890-9369.  29(19), s 2037- 2053 . doi: 10.1101/gad.269415.115
  • Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Øyvind Pernell; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Håvard; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  309(3), s H434- H449 . doi: 10.1152/ajpheart.00253.2014
  • Ougland, Rune; Rognes, Torbjørn; Klungland, Arne & Larsen, Elisabeth (2015). Non-homologous functions of the AlkB homologs. Journal of Molecular Cell Biology.  ISSN 1674-2788.  7(6), s 494- 504 . doi: 10.1093/jmcb/mjv029
  • Robertson, Adam Brian; Dahl, John Arne & Klungland, Arne (2014). DNA metabolism: bases of DNA repair and regulation.. Nature Chemical Biology.  ISSN 1552-4450.  10(7), s 487- 488 . doi: 10.1038/nchembio.1553
  • Robertson, Adam Brian; Robertson, Julia; Fusser, Markus & Klungland, Arne (2014). Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Research.  ISSN 0305-1048.  42(21), s 13280- 13293 . doi: 10.1093/nar/gku1032
  • Dahl, John Arne & Klungland, Arne (2014). Micro Chromatin Immunoprecipitation (μChIP) from Early Mammalian Embryos. Methods in Molecular Biology.  ISSN 1064-3745.  1222, s 227- 245 . doi: 10.1007/978-1-4939-1594-1_17
  • Klungland, Arne & Dahl, John Arne (2014). Dynamic RNA modifications in disease. Current Opinion in Genetics and Development.  ISSN 0959-437X.  26, s 47- 52 . doi: 10.1016/j.gde.2014.05.006
  • Nilsen, Anja; Fusser, Markus; Greggains, Gareth; Fedorcsak, Peter & Klungland, Arne (2014). ALKBH4 depletion in mice leads to spermatogenic defects. PLoS ONE.  ISSN 1932-6203.  9(8) . doi: 10.1371/journal.pone.0105113
  • Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin & Falnes, Pål (2014). Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLoS ONE.  ISSN 1932-6203.  9(6) . doi: 10.1371/journal.pone.0098729 Fulltekst i vitenarkiv
  • Solberg, Anja; Robertson, Adam Brian; Aronsen, Jan Magnus; Rognmo, Øivind; Sjaastad, Ivar; Wisløff, Ulrik & Klungland, Arne (2013). Deletion of mouse Alkbh7 leads to obesity. Journal of Molecular Cell Biology.  ISSN 1674-2788.  5(3), s 194- 203 . doi: 10.1093/jmcb/mjt012
  • Furu, Kari & Klungland, Arne (2013). Tzfp Represses the Androgen Receptor in Mouse Testis. PLoS ONE.  ISSN 1932-6203.  8(4) . doi: 10.1371/journal.pone.0062314
  • Jonson, Ida; Ougland, Rune; Klungland, Arne & Larsen, Elisabeth (2013). Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells. Stem Cell Research.  ISSN 1873-5061.  11(3), s 1264- 1271 . doi: 10.1016/j.scr.2013.08.010
  • Li, Ming-Ming; Nilsen, Anja; Shi, Yue; Fusser, Markus; Ding, Yue-He; Fu, Ye; Liu, Bo; Niu, Yamei; Wu, Yong-Sheng; Huang, Chun-Min; Olofsson, Maria; Jin, Kang-Xuan; Lv, Ying; Xu, Xing-Zhi; He, Chuan; Dong, Meng-Qiu; Danielsen, Jannie M. Rendtlew; Klungland, Arne & Yang, Yun-Gui (2013). ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. Nature Communications.  ISSN 2041-1723.  4 . doi: 10.1038/ncomms2863
  • Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min; Li, Charles J.; Vågbø, Cathrine Broberg; Shi, Yue; Wang, Wen-Ling; Song, Shu-Hui; Lu, Zhike; Bosmans, Ralph P. G.; Dai, Qing; Hao, Ya-Juan; Yang, Xin; Zhao, Wen-Ming; Tong, Wei-Min; Wang, Xiu-Jie; Bogdan, Florian; Furu, Kari; Fu, Ye; Jia, Guifang; Zhao, Xu; Liu, Jun; Krokan, Hans Einar; Klungland, Arne; Yang, Yun-Gui & He, Chuan (2013). ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Molecular Cell.  ISSN 1097-2765.  49(1), s 18- 29 . doi: 10.1016/j.molcel.2012.10.015
  • Robertson, Adam Brian; Dahl, John Arne; Ougland, Rune & Klungland, Arne (2012). Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads. Nature Protocols.  ISSN 1754-2189.  7(2), s 340- 350 . doi: 10.1038/nprot.2011.443
  • Calvo, Jennifer A; Meira, Lisiane B.; Lee, C.Y.; Moroski-Erkul, Catherine A; Abolhassani, Nona; Taghizadeh, Koli; Eichinger, Lindsey W; Muthupalani, Sureshkumar; Nordstrand, Line Mari; Klungland, Arne & Samson, Leona D. (2012). DNA repair is indispensable for survival after acute inflammation. Journal of Clinical Investigation.  ISSN 0021-9738.  122(7), s 2680- 2689 . doi: 10.1172/JCI63338
  • Kleppa, Liv; Mari, Pierre-Olivier; Larsen, Elisabeth; Lien, Guro Flor; Godon, Camille; Theil, Arjan F; Nesse, Gaute; Wiksén, Hege; Vermeulen, Wim; Giglia-Mari, Giuseppina & Klungland, Arne (2012). Kinetics of endogenous mouse FEN1 in base excision repair. Nucleic Acids Research.  ISSN 0305-1048.  40(18), s 9044- 9059 . doi: 10.1093/nar/gks673
  • Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind & Falnes, Pål (2012). The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research.  ISSN 0305-1048.  40(14), s 6620- 6631 . doi: 10.1093/nar/gks327
  • Møllersen, Linda; Rowe, Alexander D.; Illuzzi, Jennifer L.; Hildrestrand, Gunn Annette; Gerhold, Katharina J.; Tveterås, Linda Augustin; Bjølgerud, Anja; Wilson, David M.; Bjørås, Magnar & Klungland, Arne (2012). Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice. Human Molecular Genetics.  ISSN 0964-6906.  21(22), s 4939- 4947 . doi: 10.1093/hmg/dds337
  • Nordstrand, Line Mari; Furu, Kari; Paulsen, Jonas; Rognes, Torbjørn & Klungland, Arne (2012). Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nucleic Acids Research.  ISSN 0305-1048.  40(21), s 10950- 10963 . doi: 10.1093/nar/gks839
  • Ougland, Rune; Lando, David; Jonson, Ida; Dahl, John Arne; Moen, Marivi; Nordstrand, Line Mari; Rognes, Torbjørn; Lee, Jeannie T; Klungland, Arne; Kouzarides, Tony & Larsen, Elisabeth (2012). ALKBH1 Is a Histone H2A Dioxygenase Involved in Neural Differentiation. Stem Cells.  ISSN 1066-5099.  30(12), s 2672- 2682 . doi: 10.1002/stem.1228
  • Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar & Klungland, Arne (2011). A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA . Nucleic Acids Research.  ISSN 0305-1048.  39(8) . doi: 10.1093/nar/gkr051
  • Robertson, Julia; Robertson, Adam Brian & Klungland, Arne (2011). The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  411(1), s 40- 43 . doi: 10.1016/j.bbrc.2011.06.077
  • Fusser, Markus; Nesse, Gaute; Khobta, Andriy; Xia, Ning; Li, Huige; Klungland, Arne & Epe, Bernd (2011). Spontaneous mutagenesis in Csb(m/m) Ogg1(−/−) mice is attenuated by dietary resveratrol. Carcinogenesis.  ISSN 0143-3334.  32(1), s 80- 85 . doi: 10.1093/carcin/bgq196
  • Haj Yasein, Nadia Nabil; Jensen, Vidar; Vindedal, Gry Fluge; Gundersen, Georg Andreas; Klungland, Arne; Ottersen, Ole Petter; Hvalby, Øyvind Christian & Nagelhus, Erlend Arnulf (2011). Evidence that Compromised K+ Spatial Buffering Contributes to the Epileptogenic Effect of Mutations in the Human Kir4.1 Gene (KCNJ10). Glia.  ISSN 0894-1491.  59(11), s 1635- 1642 . doi: 10.1002/glia.21205
  • Haj Yasein, Nadia Nabil; Vindedal, Gry Fluge; Eilert-Olsen, Martine; Gundersen, Georg Andreas; Skare, Øivind; Laake, Petter; Klungland, Arne; Thoren, Anna; Burkhardt, John Michael; Ottersen, Ole Petter & Nagelhus, Erlend Arnulf (2011). Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(43), s 17815- 17820 . doi: 10.1073/pnas.1110655108
  • Lauritzen, Knut Husø; Chang, Cheng; Wiksén, Hege; Bergersen, Linda Hildegard & Klungland, Arne (2011). Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair.  ISSN 1568-7864.  10(6), s 639- 653 . doi: 10.1016/j.dnarep.2011.04.011
  • Lauritzen, Knut Husø; Dalhus, Bjørn; Storm, Johan Frederik; Bjørås, Magnar & Klungland, Arne (2011). Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond. Mechanisms of Ageing and Development.  ISSN 0047-6374.  132(8-9), s 424- 428 . doi: 10.1016/j.mad.2011.02.006
  • Moen, Marivi; Knævelsrud, Ingeborg; Haugland, Gyri Teien; Grøsvik, Kristin; Birkeland, Nils-Kåre; Klungland, Arne & Bjelland, Svein (2011). Uracil-DNA Glycosylase of Thermoplasma acidophilum Directs Long-Patch Base Excision Repair, Which Is Promoted by Deoxynucleoside Triphosphates and ATP/ADP, into Short-Patch Repair. Journal of Bacteriology.  ISSN 0021-9193.  193(17), s 4495- 4508 . doi: 10.1128/JB.00233-11
  • Strømme, Petter; Dobrenis, Kostantin; Sillitoe, Roy V.; Gulinello, Maria; Ali, Nafeeza F.; Davidson, Christin; Micsenyi, Matthew C.; Stephney, Gloria; Ellevog, Linda; Klungland, Arne & Walkley, Steven U. (2011). X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction. Brain.  ISSN 0006-8950.  134, s 3369- 3383 . doi: 10.1093/brain/awr250
  • Thrane, Alexander Stanley; Rappold, Philip M; Fujita, Takumi; Torres, Arnulfo; Bekar, Lane K; Takano, Takahiro; Peng, Weiguo; Wang, Fushun; Thrane Rangroo, Vinita; Enger, Rune; Haj Yasein, Nadia Nabil; Skare, Øivind; Holen, Torgeir; Klungland, Arne; Ottersen, Ole Petter; Nedergaard, Maiken & Nagelhus, Erlend Arnulf (2011). Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(2), s 846- 851 . doi: 10.1073/pnas.1015217108
  • Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne & Falnes, Pål (2011). ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications.  ISSN 2041-1723.  2 . doi: 10.1038/ncomms1173
  • Dahl, John Arne; Reiner, Andrew Henry; Klungland, Arne; Wakayama, Teruhiko & Collas, Philippe (2010). Histone H3 Lysine 27 Methylation Asymmetry on Developmentally-Regulated Promoters Distinguish the First Two Lineages in Mouse Preimplantation Embryos. PLoS ONE.  ISSN 1932-6203.  5(2) . doi: 10.1371/journal.pone.0009150
  • Knævelsrud, Ingeborg; Moen, Marivi; Grøsvik, Kristin; Haugland, Gyri Teien; Birkeland, Nils-Kåre; Klungland, Arne; Leiros, Ingar & Bjelland, Svein (2010). The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement. Journal of Bacteriology.  ISSN 0021-9193.  192(21), s 5755- 5766 . doi: 10.1128/JB.00135-10
  • Lauritzen, Knut Husø; Moldestad, Olve; Eide, Lars; Carlsen, Harald; Nesse, Gaute; Storm, Johan Frederik; Mansuy, Isabelle M.; Bergersen, Linda Hildegard & Klungland, Arne (2010). Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior. Molecular and Cellular Biology.  ISSN 0270-7306.  30(6), s 1357- 1367 . doi: 10.1128/MCB.01149-09
  • Møllersen, Linda; Rowe, Alexander D.; Larsen, Elisabeth; Rognes, Torbjørn & Klungland, Arne (2010). Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice. PLoS Genetics.  ISSN 1553-7390.  6(12) . doi: 10.1371/journal.pgen.1001242
  • Nordstrand, Line Mari; Svärd, Jessica; Larsen, Elisabeth; Nilsen, Anja; Ougland, Rune; Furu, Kari; Lien, Guro Flor; Rognes, Torbjørn; Namekawa, Satoshi H; Lee, Jeannie T & Klungland, Arne (2010). Mice Lacking Alkbh1 Display Sex-Ratio Distortion and Unilateral Eye Defects. PLoS ONE.  ISSN 1932-6203.  5(11) . doi: 10.1371/journal.pone.0013827
  • Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO & Klungland, A (2010). Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding . Molecular and Cellular Biology.  ISSN 0270-7306.  30(7), s 1814- 1827 . doi: 10.1128/MCB.01602-09
  • Robertson, AB; Klungland, A; Rognes, T & Leiros, Ingar (2009). DNA Repair in Mammalian Cells. Cellular and Molecular Life Sciences (CMLS).  ISSN 1420-682X.  66(6), s 981- 993 . doi: 10.1007/s00018-009-8736-z
  • Van den Born, Erwin; Bekkelund, Anders; Moen, Marivi; Omelchenko, M.V.; Klungland, Arne & Falnes, Pål (2009). Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria. Nucleic Acids Research.  ISSN 0305-1048.  37(21) . doi: 10.1093/nar/gkp774
  • Larsen, Elisabeth; Kleppa, Liv; Meza, Trine Johansen; Meza, Zepeda Leonardo; Rada, C; Castellanos, Cesilie Granum; Lien, Guro Flor; Nesse, Gaute; Neuberger, MS; Lærdahl, Jon Kristen; Doughty, RW & Klungland, Arne (2008). Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants. Cancer Research.  ISSN 0008-5472.  68, s 4571- 4579 . doi: 10.1158/0008-5472.CAN-08-0168
  • Ringvoll, Jeanette; Moen, Marivi N.; Nordstrand, Line M.; Meira, Lisiane B.; Pang, Bo; Bekkelund, Anders; Dedon, Peter C.; Bjelland, Svein; Samson, Leona D.; Falnes, Pål Ø. & Klungland, Arne (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research.  ISSN 0008-5472.  68(11), s 4142- 4149
  • Saxowsky, TT; Meadows, KL; Klungland, Arne & Doetsch, PW (2008). 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  105(48), s 18877- 18882 . doi: 10.1073/pnas.0806464105
  • Wærsted, Jeanette Ringvoll; Nabong, Marivi; Nordstrand, Line Mari; Meira, LB; Pang, B; Bekkelund, Anders; Dedon, PC; Bjelland, S; Samson, LD; Falnes, Pål & Klungland, Arne (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research.  ISSN 0008-5472.  68(11), s 4142- 4149 . doi: 10.1158/0008-5472.CAN-08-0796
  • Falnes, Pål; Klungland, Arne & Alseth, Ingrun (2007). Repair of methyl lesions in DNA and RNA by oxidative demethylation. Neuroscience.  ISSN 0306-4522.  145 . doi: 10.1016/j.neuroscience.2006.11.018
  • Kleppa, Liv; Kanavin, Øivind Juris; Klungland, Arne & Strømme, Petter (2007). A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome. Neuroscience.  ISSN 0306-4522.  4, s 1397- 1406 . doi: 10.1016/j.neuroscience.2006.09.025
  • Klungland, Arne & Bjelland, Svein (2007). Oxidative damage to purines in DNA: Role of mammalian Ogg1. DNA Repair.  ISSN 1568-7864.  6
  • Klungland, Arne; Lærdahl, Jon Kristen & Rognes, Torbjørn (2007). OGG1: From Structural Analysis to the Knockout Mouse, In Mark D. Evans & Marcus S. Cooke (ed.),  Oxidative Damage to Nucleic Acids.  Springer Science+Business Media B.V..  ISBN 9780387729732.  Chapter 5.  s 67 - 80
  • Kovtun, IV; Liu, Y; Bjørås, Magnar; Klungland, Arne; Wilson, SH & McMurray, CT (2007). OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature.  ISSN 0028-0836.  447 . doi: 10.1038/nature05778
  • Larsen, E; Meza, TJ; Kleppa, L & Klungland, Arne (2007). Organ and cell specificity of base excision repair mutants in mice. Mutation research.  ISSN 0027-5107.  614, s 56- 68 . doi: 10.1016/j.mrfmmm.2006.01.023
  • Leiros, Ingar; Nabong, Marivi P.; Grøsvik, Kristin; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Reite, Karen; Olsbu, Inger K.; Knævelsrud, I.; Moe, Elin; Andersen, Ole A.; Birkeland, Nils-Kåre; Ruoff, Peter; Klungland, Arne & Bjelland, Svein (2007). Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal.  ISSN 0261-4189.  26
  • Leiros, Ingar; Nabong, Marivi; Nabong, MP; Grosvik, K; Grøsvik, Kristin; Ringvoll, J; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Uldal, L; Reite, K; Olsbu, IK; Knævelsrud, Ingeborg; Knaevelsrud, I; Moe, Elin; Andersen, Ole Andreas; Birkeland, NK; Ruoff, P; Klungland, A & Bjelland, S (2007). Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal.  ISSN 0261-4189.  26 . doi: 10.1038/sj.emboj.7601662
  • Nordstrand, Line Mari; Ringvoll, Jeanette; Larsen, Elisabeth & Klungland, Arne (2007). Genome instability and DNA damage accumulation in gene-targeted mice. Neuroscience.  ISSN 0306-4522.  145 . doi: 10.1016/j.neuroscience.2006.10.059
  • Ringvoll, Jeanette; Uldal, Lene; Røed, Marie Aslaksen; Stenersen, Karen Oppland; Baynton, K; Klungland, Arne & Eide, Lars (2007). Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol. FEMS yeast research (Print).  ISSN 1567-1356.  7, s 848- 859 . doi: 10.1111/j.1567-1364.2007.00248.x
  • Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB; Talstad, Vivi; Reite, Karen; Aas, Per Arne; Lauritzen, Knut H.; Liabakk, Nina-Beate; Bjørk, Alexandra; Doughty, Richard William; Falnes, Pål Ø.; Krokan, Hans Einar & Klungland, Arne (2006). Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal.  ISSN 0261-4189.  25, s 2189- 2198
  • Kleppa, Liv; Kanavin, Ø.J; Klungland, Arne & Strømme, Petter (2006). A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome. Neuroscience.  ISSN 0306-4522. . doi: 10.1016/j.neuroscience
  • Larsen, Elisabeth; Stenersen, Karen Oppland; Nesse, Gaute; Neurauter, Christine Gran; Seeberg, Erling Christen & Klungland, Arne (2006). Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1(-/-) mice. Oncogene.  ISSN 0950-9232.  25, s 2425- 2432
  • Touati, E; Michel, V; Thiberge, JM; Ave, P; Huerre, M; Bourgade, F; Klungland, Arne & Labigne, A (2006). Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H-Pylori infection in mouse. Helicobacter.  ISSN 1083-4389.  11, s 494- 505
  • Holen, Torgeir; Moe, Svein Erik E; Sørbø, Jan Gunnar; Meza, Trine Johansen; Ottersen, Ole Petter & Klungland, Arne (2005). Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo. Nucleic Acids Research.  ISSN 0305-1048.  33(15), s 4704- 4710 . doi: 10.1093/nar/gki785
  • Rozalski, R; Siomek, A; Gackowski, D; Foksinski, M; Gran, C; Klungland, Arne & Olinski, R (2005). Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice. International Journal of Biochemistry and Cell Biology.  ISSN 1357-2725.  37
  • Rozalski, R; Siomek, A; Gackowski, D; Gran, Christine; Foksinski, M; Gran, C; Klungland, Arne & Olinski, R (2004). Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine. Free radical research.  ISSN 1071-5762.  38(11), s 1201- 1205
  • Foksinski, M; Rozalski, R; Guz, J; Ruszkowska, B; Sztukowska, P; Piwowarski, M; Klungland, Arne & Olinski, R (2004). Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species. Free Radical Biology & Medicine.  ISSN 0891-5849.  37(9), s 1449- 1454
  • Larsen, E; Kwon, K; Coin, F; Egly, JM & Klungland, Arne (2004). Transcription activities at 8-oxoG lesions in DNA. DNA Repair.  ISSN 1568-7864.  3(11), s 1457- 1468
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Knævelsrud, Ingeborg; Kristoffersen, Wenche; Bjørås, M.; Robb, F.T.; Klungland, Arne & Bjelland, Svein (2002). Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus. Biochemistry.  ISSN 1520-4995.  41, s 12697- 12705
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Knævelsrud, Ingeborg; Kristoffersen, Wenche; Bjørås, M.; Robb, F.T.; Klungland, Arne & Bjelland, Svein (2002). Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus. Biochemistry.  ISSN 1520-4995.  41, s 12697- 12705
  • Bjelland, Svein; Klungland, Arne; Paulsen, R.; Rolseth, V.; Yamada, Y.; Ueno, Y.; Wiik, P.; Matsuda, A. & Seeberg, E. (2001). 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism. Toxicology Letters.  ISSN 0378-4274.  119, s 71- 78
  • Klungland, Helge & Klungland, Arne (2000). År 2000-2100: Genetikkens århundre?. Kirke og kultur.  ISSN 0023-186X.  105(05.jun), s 461- 476

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  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn; Klungland, Arne & Bjelland, Svein (2017). hSMUG1 is a bi-functional DNA glycosylase.
  • Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein (2017). Repair of double methylated bases in DNA.
  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn; Klungland, Arne & Bjelland, Svein (2016). hSMUG1-catalysed uracil-DNA strand incision.
  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn; Klungland, Arne & Bjelland, Svein (2016). hSMUG1-catalysed uracil-DNA strand incision.
  • Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein (2016). Repair of double methylated bases in DNA.
  • Catterall, Tara Cherie; Johnson, Inna; Khan, Shaista; Jermstad, Ingunn; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2015). The Norwegian Transgenic Centre.
  • Khan, Shaista; Jermstad, Ingunn; Catterall, Tara Cherie; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2014). The Norwegian Transgenic Centre.
  • Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne & Amdam, Gro Vang (2014). Epigenetically modified cytosines in the honey bee genome.
  • Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne & Amdam, Gro Vang (2013). Presence of modified cytosines in the honey bee genome.
  • Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fu, Ye & Klungland, Arne (2013). Sprouts of RNA epigenetics The discovery of mammalian RNA demethylases. RNA Biology.  ISSN 1547-6286.  10(6), s 915- 918 . doi: 10.4161/rna.24711
  • Warken, D.; Khobta, Andriy; Klungland, Arne & Epe, B. (2010). Flap endonuclease 1 (FEN-1) takes part in repair of DNA single-strand breaks. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  381, s 73- 73
  • Falnes, Pål; Van den Born, Erwin; Leihne, VIbeke; Meza, Trine Johansen; Songe-Møller, Lene & Klungland, Arne (2009). AlkB-like dioxygenases-roles in nucleic acid repair and modification.
  • Klungland, Arne & Andersson, Kristin Brevik (2007). Nobelpris for genmodifisering. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  23, s 127- 127
  • Leiros, Ingar; Nabong, Marivi P.; Haugland, GT; Ringvoll, Jeanette; Grøsvik, K; Grøsvik, K; Moe, Elin; Knævelsrud, I.; Knævelsrud, I.; Reite, Karen; Andersen, Ole A.; Birkeland, Nils-Kåre; Klungland, Arne; Bjelland, Svein & Bjelland, Svein (2006). Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus.
  • Trapp, C; Klungland, Arne & Epe, B (2006). The peroxisome proliferator WY-14,643 does not induce oxidative DNA damage in repair-deficient Csb(-/-)Ogg1(-/-) knockout mice. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  372, s 112- 112
  • Meza, Trine Johansen; Elisabeth, Larsen; Nesse, Gaute & Klungland, Arne (2005). Knock-down studies of FEN1 by gene targeting and RNAi.
  • Meza, Trine Johansen; Elisabeth, Larsen; Halsne, Ruth & Klungland, Arne (2004). Knock-down studies of FEN1 by gene targeting and RNAi.
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Kristoffersen, Wenche; Knævelsrud, Ingeborg; Bjørås, M.; Klungland, Arne; Robb, F.T. & Bjelland, Svein (2002). Cold-active methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Kristoffersen, Wenche; Knævelsrud, Ingeborg; Bjørås, M.; Klungland, Arne; Robb, F.T. & Bjelland, Svein (2002). Cold-active methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.
  • Klungland, Arne; Klungland, Helge & Kjær, Jan Erik (1998). Derfor er dyrene forskjellige. Buskap.  ISSN 0007-7194.  50(4), s 10- 11
  • Klungland, Helge; Klungland, Arne & Kjær, Jan Erik (1998). Gener i avlsarbeidet. Buskap.  ISSN 0007-7194.  50(5), s 20- 22
  • Klungland, Helge; Klungland, Arne & Kjær, Jan Erik (1998). Gener og kromosomer. Buskap.  ISSN 0007-7194.  50(3), s 36- 37

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Publisert 13. apr. 2011 10:38 - Sist endret 16. okt. 2017 22:25

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