Arne Klungland

Professor II - Seksjon for Biokjemi
Bilde av Arne Klungland
English version of this page
Telefon +47-23074072
Mobiltelefon +47-47840305
Faks +47-23074061
Rom A3.3021
Brukernavn
Besøksadresse OUS Rikshospitalet bygg A 3. etasje
Postadresse Postboks 1112 Blindern 0317 OSLO
Andre tilknytninger Institutt for medisinske basalfag

Faglige interesser

Epigenetikk, embryoutvikling, RNA, histonmodifikasjoner, DNA reparasjon.

Se også forskningsgruppens websider ved OUS.

Undervisning

PhD emne MF9225 - "A molecular approach to genetic and epigenetic gene regulation, from basic research to the clinic."

Bakgrunn

2016 - d.d. Seksjonsleder ved Forskningsseksjonen, Avdeling for mikrobiologi, Klinikk for laboratoriemedisin, Oslo Universitetssykehus

2013 - d.d. Professor II ved Seksjon for biokjemi, Avdeling for molekylærmedisin, Institutt for medisinske basalfag

2001 - 2016 Forsker ved Forskningsseksjonen, Avdeling for mikrobiologi, Klinikk for laboratoriemedisin, Oslo Universitetssykehus

2005 - 2013 Professor I ved Seksjon for biokjemi, Avdeling for molekylærmedisin, Institutt for medisinske basalfag

Verv

2012 - d.d. Medlem av Fagrådet for komparativ medisin, OSS, Oslo Universitetssykehus

 

Emneord: epigenetikk, embryoutvikling, RNA, histonmodifikasjoner, DNA reparasjon

Publikasjoner

  • Aas, Aleksander; Isakson, Pauline; Bindesbøll, Christian; Alemu, Endalkachew Ashenafi; Klungland, Arne & Simonsen, Anne (2017). Nucleocytoplasmic shuttling of FTO does not affect starvation-induced autophagy. PLoS ONE.  ISSN 1932-6203.  12:e0168182(3), s 1- 15 . doi: 10.1371/journal.pone.0168182
  • Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Robertson, Joseph; Klungland, Arne & Enserink, Jorrit (2017). TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  114(5), s 1039- 1044 . doi: 10.1073/pnas.1615093114
  • Kalikstad, Betty; Kultima, Hanna Goransson; Andersstuen, Terese; Klungland, Arne & Isaksson, Anders (2017). Gene expression profiles in preterm infants on continuous long-term oxygen therapy suggest reduced oxidative stress-dependent signaling during hypoxia. Molecular Medicine Reports.  ISSN 1791-2997.  15(4), s 1513- 1526 . doi: 10.3892/mmr.2017.6185
  • Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C.; He, Chuan; Sjaastad, Ivar; Sætrom, Pål; Fedorcsák, Péter; Dahl, John Arne; Aanes, Håvard; Fusser, Markus & Klungland, Arne (2017). Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discovery.  ISSN 2056-5968.  3:170013, s 1- 14 . doi: 10.1038/celldisc.2017.13
  • Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar & Finsen, Alexandra (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports.  ISSN 2211-1247.  18, s 82- 92 . doi: 10.1016/j.celrep.2016.12.009
  • Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne; Andersen, Jill Mari; Slupphaug, Geir; Klungland, Arne; Nilsen, Hilde & Bjørås, Magnar (2017). No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-04472-4 Fulltekst i vitenarkiv.
  • Seifermann, Marco; Ulges, Alexander; Bopp, Tobias; Melcea, Svetlana; Schäfer, Andrea; Oka, Sugako; Nakabeppu, Yusaku; Klungland, Arne; Niehrs, Christof & Epe, Bernd (2017). Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair.  ISSN 1568-7864.  58, s 13- 20 . doi: 10.1016/j.dnarep.2017.08.005
  • Klungland, Arne & Robertson, Adam Brian (2016). Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine. Free Radical Biology & Medicine.  ISSN 0891-5849.  107, s 62- 68 . doi: 10.1016/j.freeradbiomed.2016.11.038
  • Alemu, Endalkachew Ashenafi; He, Chuan & Klungland, Arne (2016). ALKBHs-facilitated RNA modifications and de-modifications. DNA Repair.  ISSN 1568-7864.  44, s 87- 91 . doi: 10.1016/j.dnarep.2016.05.026
  • Dahl, John Arne; Jung, Inkyung; Aanes, Håvard; Greggains, Gareth; Manaf, Adeel; Lerdrup, Mads; Li, Guoqiang; Kuan, Samantha; Li, Bin; Lee, Ah Young; Preissl, Sebastian; Jermstad, Ingunn; Haugen, Mads Haugland; Suganthan, Rajikala; Bjørås, Magnar; Hansen, Klaus; Dalen, Knut Tomas; Fedorcsák, Péter; Ren, Bing & Klungland, Arne (2016). Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature.  ISSN 0028-0836.  537(7621), s 548- 552 . doi: 10.1038/nature19360
  • Klungland, Arne; Dahl, John Arne; Greggains, Gareth; Fedorcsák, Péter & Filipczyk, Adam (2016). Reversible RNA modifications in meiosis and pluripotency. Nature Methods.  ISSN 1548-7091.  14(1), s 18- 22 . doi: 10.1038/nmeth.4111
  • Landfors, Miriam; Nakken, Sigve; Fusser, Markus; Dahl, John Arne; Klungland, Arne & Fedorcsák, Péter (2016). Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations. Fertility and Sterility.  ISSN 0015-0282.  105(5), s 1170- 1179e5 . doi: 10.1016/j.fertnstert.2016.01.002
  • Lauritzen, Knut Husø; Hasan-Olive, Md Mahdi; Regnell, Christine E; Kleppa, Liv; Scheibye Knudsen, Morten; Gjedde, Albert; Klungland, Arne; Bohr, Vilhelm A; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiology of Aging.  ISSN 0197-4580.  48, s 34- 47 . doi: 10.1016/j.neurobiolaging.2016.08.005
  • Liu, Fange; Clark, Wesley; Luo, Guanzheng; Wang, Xiaoyun; Fu, Ye; Wei, Jiangbo; Wang, Xiao; Hao, Ziyang; Dai, Qing; Zheng, Guanqun; Ma, Honghui; Han, Dali; Evans, Molly; Klungland, Arne; Pan, Tao & He, Chuan (2016). ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell.  ISSN 0092-8674.  167(3), s 816- 828 . doi: 10.1016/j.cell.2016.09.038
  • Mi, Shuangli; Klungland, Arne & Yang, Yun-Gui (2016). Base-excision repair and beyond —A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015. Science China Life Sciences.  ISSN 1674-7305.  59(1), s 89- 92 . doi: 10.1007/s11427-015-4983-4
  • Møllersen, Linda; Moldestad, Olve; Rowe, Alexander D.; Bjølgerud, Anja; Holm, Ingunn; Tveterås, Linda Augustin; Klungland, Arne & Retterstøl, Lars (2016). Effects of anthocyanins on CAG repeat instability and behaviour in Huntington's disease R6/1 mice. PLOS Currents.  ISSN 2157-3999.  8(HuntingtonDisease, 2016)
  • Ougland, Rune; Jonson, Ida; Moen, Marivi Nabong; Nesse, Gaute; Asker, Gry; Klungland, Arne & Larsen, Elisabeth (2016). Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells. Cellular Physiology and Biochemistry.  ISSN 1015-8987.  38(1), s 173- 184 . doi: 10.1159/000438619
  • Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang & Dahl, John Arne (2016). DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates. Biochemistry and Biophysics Reports.  ISSN 2405-5808.  6, s 9- 15 . doi: 10.1016/j.bbrep.2016.02.011
  • Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine Broberg; Lyle, Robert; Kringen, Marianne K.; Staff, Anne Cathrine; Dybedal, Ingunn; Mills, Ian Geoffrey; Klungland, Arne & Staerk, Judith (2016). Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics & Chromatin.  ISSN 1756-8935.  9 . doi: 10.1186/s13072-016-0070-8
  • Vindedal, Gry Fluge; Thoren, Anna; Jensen, Vidar; Klungland, Arne; Zhang, Yong; Holtzman, Michael; Ottersen, Ole Petter & Nagelhus, Erlend Arnulf (2016). Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Molecular and Cellular Neuroscience.  ISSN 1044-7431.  77, s 47- 52 . doi: 10.1016/j.mcn.2016.10.004
  • Weber, Alain R.; Krawczyk, Claudia; Robertson, Adam Brian; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Schürmann, David; Klungland, Arne & Schär, Primo (2016). Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nature Communications.  ISSN 2041-1723.  7 . doi: 10.1038/ncomms10806
  • Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne & Bjørås, Magnar (2015). Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports.  ISSN 2211-1247.  13(12), s 2671- 2678 . doi: 10.1016/j.celrep.2015.12.001 Fulltekst i vitenarkiv. Vis sammendrag
  • Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Koehler, Christian; Thiede, Bernd; Lorenz, Susanne; Meza, Leonardo Zepeda; Klungland, Arne & Enserink, Jorrit (2015). Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes. Genome Research.  ISSN 1088-9051.  25(6), s 897- 906 . doi: 10.1101/gr.185793.114
  • Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål & Klungland, Arne (2015). Lysine methylation of the valosin-containing protein (VCP) is dispensable for development and survival of mice. PLoS ONE.  ISSN 1932-6203.  10(11) . doi: 10.1371/journal.pone.0141472 Fulltekst i vitenarkiv.
  • Ke, Shengdong; Alemu, Endalkachew Ashenafi; Mertens, Claudia; Gantman, Emily Conn; Fak, John J.; Mele, Aldo; Haripal, Bhagwattie; Zucker-Scharff, Ilana; Moore, Michael J.; Park, Christopher Y.; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Klungland, Arne; Darnell, James E. & Darnell, Robert B. (2015). A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes & Development.  ISSN 0890-9369.  29(19), s 2037- 2053 . doi: 10.1101/gad.269415.115
  • Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Øyvind Pernell; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Håvard; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  309(3), s H434- H449 . doi: 10.1152/ajpheart.00253.2014
  • Ougland, Rune; Rognes, Torbjørn; Klungland, Arne & Larsen, Elisabeth (2015). Non-homologous functions of the AlkB homologs. Journal of Molecular Cell Biology.  ISSN 1674-2788.  7(6), s 494- 504 . doi: 10.1093/jmcb/mjv029
  • Robertson, Adam Brian; Dahl, John Arne & Klungland, Arne (2014). DNA metabolism: bases of DNA repair and regulation.. Nature Chemical Biology.  ISSN 1552-4450.  10(7), s 487- 488 . doi: 10.1038/nchembio.1553
  • Robertson, Adam Brian; Robertson, Julia; Fusser, Markus & Klungland, Arne (2014). Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Research.  ISSN 0305-1048.  42(21), s 13280- 13293 . doi: 10.1093/nar/gku1032
  • Dahl, John Arne & Klungland, Arne (2014). Micro Chromatin Immunoprecipitation (μChIP) from Early Mammalian Embryos. Methods in Molecular Biology.  ISSN 1064-3745.  1222, s 227- 245 . doi: 10.1007/978-1-4939-1594-1_17
  • Klungland, Arne & Dahl, John Arne (2014). Dynamic RNA modifications in disease. Current Opinion in Genetics and Development.  ISSN 0959-437X.  26, s 47- 52 . doi: 10.1016/j.gde.2014.05.006
  • Nilsen, Anja; Fusser, Markus; Greggains, Gareth; Fedorcsak, Peter & Klungland, Arne (2014). ALKBH4 depletion in mice leads to spermatogenic defects. PLoS ONE.  ISSN 1932-6203.  9(8) . doi: 10.1371/journal.pone.0105113
  • Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin & Falnes, Pål (2014). Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLoS ONE.  ISSN 1932-6203.  9(6) . doi: 10.1371/journal.pone.0098729 Fulltekst i vitenarkiv.
  • Solberg, Anja; Robertson, Adam Brian; Aronsen, Jan Magnus; Rognmo, Øivind; Sjaastad, Ivar; Wisløff, Ulrik & Klungland, Arne (2013). Deletion of mouse Alkbh7 leads to obesity. Journal of Molecular Cell Biology.  ISSN 1674-2788.  5(3), s 194- 203 . doi: 10.1093/jmcb/mjt012
  • Furu, Kari & Klungland, Arne (2013). Tzfp Represses the Androgen Receptor in Mouse Testis. PLoS ONE.  ISSN 1932-6203.  8(4) . doi: 10.1371/journal.pone.0062314
  • Jonson, Ida; Ougland, Rune; Klungland, Arne & Larsen, Elisabeth (2013). Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells. Stem Cell Research.  ISSN 1873-5061.  11(3), s 1264- 1271 . doi: 10.1016/j.scr.2013.08.010
  • Li, Ming-Ming; Nilsen, Anja; Shi, Yue; Fusser, Markus; Ding, Yue-He; Fu, Ye; Liu, Bo; Niu, Yamei; Wu, Yong-Sheng; Huang, Chun-Min; Olofsson, Maria; Jin, Kang-Xuan; Lv, Ying; Xu, Xing-Zhi; He, Chuan; Dong, Meng-Qiu; Danielsen, Jannie M. Rendtlew; Klungland, Arne & Yang, Yun-Gui (2013). ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. Nature Communications.  ISSN 2041-1723.  4 . doi: 10.1038/ncomms2863
  • Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min; Li, Charles J.; Vågbø, Cathrine Broberg; Shi, Yue; Wang, Wen-Ling; Song, Shu-Hui; Lu, Zhike; Bosmans, Ralph P. G.; Dai, Qing; Hao, Ya-Juan; Yang, Xin; Zhao, Wen-Ming; Tong, Wei-Min; Wang, Xiu-Jie; Bogdan, Florian; Furu, Kari; Fu, Ye; Jia, Guifang; Zhao, Xu; Liu, Jun; Krokan, Hans Einar; Klungland, Arne; Yang, Yun-Gui & He, Chuan (2013). ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Molecular Cell.  ISSN 1097-2765.  49(1), s 18- 29 . doi: 10.1016/j.molcel.2012.10.015
  • Robertson, Adam Brian; Dahl, John Arne; Ougland, Rune & Klungland, Arne (2012). Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads. Nature Protocols.  ISSN 1754-2189.  7(2), s 340- 350 . doi: 10.1038/nprot.2011.443
  • Calvo, Jennifer A; Meira, Lisiane B.; Lee, C.Y.; Moroski-Erkul, Catherine A; Abolhassani, Nona; Taghizadeh, Koli; Eichinger, Lindsey W; Muthupalani, Sureshkumar; Nordstrand, Line Mari; Klungland, Arne & Samson, Leona D. (2012). DNA repair is indispensable for survival after acute inflammation. Journal of Clinical Investigation.  ISSN 0021-9738.  122(7), s 2680- 2689 . doi: 10.1172/JCI63338
  • Kleppa, Liv; Mari, Pierre-Olivier; Larsen, Elisabeth; Lien, Guro Flor; Godon, Camille; Theil, Arjan F; Nesse, Gaute; Wiksén, Hege; Vermeulen, Wim; Giglia-Mari, Giuseppina & Klungland, Arne (2012). Kinetics of endogenous mouse FEN1 in base excision repair. Nucleic Acids Research.  ISSN 0305-1048.  40(18), s 9044- 9059 . doi: 10.1093/nar/gks673
  • Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind & Falnes, Pål (2012). The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research.  ISSN 0305-1048.  40(14), s 6620- 6631 . doi: 10.1093/nar/gks327
  • Møllersen, Linda; Rowe, Alexander D.; Illuzzi, Jennifer L.; Hildrestrand, Gunn Annette; Gerhold, Katharina J.; Tveterås, Linda Augustin; Bjølgerud, Anja; Wilson, David M.; Bjørås, Magnar & Klungland, Arne (2012). Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice. Human Molecular Genetics.  ISSN 0964-6906.  21(22), s 4939- 4947 . doi: 10.1093/hmg/dds337
  • Nordstrand, Line Mari; Furu, Kari; Paulsen, Jonas; Rognes, Torbjørn & Klungland, Arne (2012). Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nucleic Acids Research.  ISSN 0305-1048.  40(21), s 10950- 10963 . doi: 10.1093/nar/gks839
  • Ougland, Rune; Lando, David; Jonson, Ida; Dahl, John Arne; Moen, Marivi; Nordstrand, Line Mari; Rognes, Torbjørn; Lee, Jeannie T; Klungland, Arne; Kouzarides, Tony & Larsen, Elisabeth (2012). ALKBH1 Is a Histone H2A Dioxygenase Involved in Neural Differentiation. Stem Cells.  ISSN 1066-5099.  30(12), s 2672- 2682 . doi: 10.1002/stem.1228
  • Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar & Klungland, Arne (2011). A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Research.  ISSN 0305-1048.  39(8) . doi: 10.1093/nar/gkr051
  • Robertson, Julia; Robertson, Adam Brian & Klungland, Arne (2011). The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  411(1), s 40- 43 . doi: 10.1016/j.bbrc.2011.06.077
  • Fusser, Markus; Nesse, Gaute; Khobta, Andriy; Xia, Ning; Li, Huige; Klungland, Arne & Epe, Bernd (2011). Spontaneous mutagenesis in Csb(m/m) Ogg1(−/−) mice is attenuated by dietary resveratrol. Carcinogenesis.  ISSN 0143-3334.  32(1), s 80- 85 . doi: 10.1093/carcin/bgq196
  • Haj Yasein, Nadia Nabil; Jensen, Vidar; Vindedal, Gry Fluge; Gundersen, Georg Andreas; Klungland, Arne; Ottersen, Ole Petter; Hvalby, Øyvind Christian & Nagelhus, Erlend Arnulf (2011). Evidence that Compromised K+ Spatial Buffering Contributes to the Epileptogenic Effect of Mutations in the Human Kir4.1 Gene (KCNJ10). Glia.  ISSN 0894-1491.  59(11), s 1635- 1642 . doi: 10.1002/glia.21205
  • Haj Yasein, Nadia Nabil; Vindedal, Gry Fluge; Eilert-Olsen, Martine; Gundersen, Georg Andreas; Skare, Øivind; Laake, Petter; Klungland, Arne; Thoren, Anna; Burkhardt, John Michael; Ottersen, Ole Petter & Nagelhus, Erlend Arnulf (2011). Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(43), s 17815- 17820 . doi: 10.1073/pnas.1110655108
  • Lauritzen, Knut Husø; Chang, Cheng; Wiksén, Hege; Bergersen, Linda Hildegard & Klungland, Arne (2011). Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair.  ISSN 1568-7864.  10(6), s 639- 653 . doi: 10.1016/j.dnarep.2011.04.011
  • Lauritzen, Knut Husø; Dalhus, Bjørn; Storm, Johan Frederik; Bjørås, Magnar & Klungland, Arne (2011). Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond. Mechanisms of Ageing and Development.  ISSN 0047-6374.  132(8-9), s 424- 428 . doi: 10.1016/j.mad.2011.02.006
  • Moen, Marivi; Knævelsrud, Ingeborg; Haugland, Gyri Teien; Grøsvik, Kristin; Birkeland, Nils-Kåre; Klungland, Arne & Bjelland, Svein (2011). Uracil-DNA Glycosylase of Thermoplasma acidophilum Directs Long-Patch Base Excision Repair, Which Is Promoted by Deoxynucleoside Triphosphates and ATP/ADP, into Short-Patch Repair. Journal of Bacteriology.  ISSN 0021-9193.  193(17), s 4495- 4508 . doi: 10.1128/JB.00233-11
  • Strømme, Petter; Dobrenis, Kostantin; Sillitoe, Roy V.; Gulinello, Maria; Ali, Nafeeza F.; Davidson, Christin; Micsenyi, Matthew C.; Stephney, Gloria; Ellevog, Linda; Klungland, Arne & Walkley, Steven U. (2011). X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction. Brain.  ISSN 0006-8950.  134, s 3369- 3383 . doi: 10.1093/brain/awr250
  • Thrane, Alexander Stanley; Rappold, Philip M; Fujita, Takumi; Torres, Arnulfo; Bekar, Lane K; Takano, Takahiro; Peng, Weiguo; Wang, Fushun; Thrane Rangroo, Vinita; Enger, Rune; Haj Yasein, Nadia Nabil; Skare, Øivind; Holen, Torgeir; Klungland, Arne; Ottersen, Ole Petter; Nedergaard, Maiken & Nagelhus, Erlend Arnulf (2011). Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(2), s 846- 851 . doi: 10.1073/pnas.1015217108
  • Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne & Falnes, Pål (2011). ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications.  ISSN 2041-1723.  2 . doi: 10.1038/ncomms1173
  • Dahl, John Arne; Reiner, Andrew Henry; Klungland, Arne; Wakayama, Teruhiko & Collas, Philippe (2010). Histone H3 Lysine 27 Methylation Asymmetry on Developmentally-Regulated Promoters Distinguish the First Two Lineages in Mouse Preimplantation Embryos. PLoS ONE.  ISSN 1932-6203.  5(2) . doi: 10.1371/journal.pone.0009150
  • Knævelsrud, Ingeborg; Moen, Marivi; Grøsvik, Kristin; Haugland, Gyri Teien; Birkeland, Nils-Kåre; Klungland, Arne; Leiros, Ingar & Bjelland, Svein (2010). The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement. Journal of Bacteriology.  ISSN 0021-9193.  192(21), s 5755- 5766 . doi: 10.1128/JB.00135-10 Vis sammendrag
  • Lauritzen, Knut Husø; Moldestad, Olve; Eide, Lars; Carlsen, Harald; Nesse, Gaute; Storm, Johan Frederik; Mansuy, Isabelle M.; Bergersen, Linda Hildegard & Klungland, Arne (2010). Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior. Molecular and Cellular Biology.  ISSN 0270-7306.  30(6), s 1357- 1367 . doi: 10.1128/MCB.01149-09 Vis sammendrag
  • Møllersen, Linda; Rowe, Alexander D.; Larsen, Elisabeth; Rognes, Torbjørn & Klungland, Arne (2010). Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice. PLoS Genetics.  ISSN 1553-7390.  6(12) . doi: 10.1371/journal.pgen.1001242
  • Nordstrand, Line Mari; Svärd, Jessica; Larsen, Elisabeth; Nilsen, Anja; Ougland, Rune; Furu, Kari; Lien, Guro Flor; Rognes, Torbjørn; Namekawa, Satoshi H; Lee, Jeannie T & Klungland, Arne (2010). Mice Lacking Alkbh1 Display Sex-Ratio Distortion and Unilateral Eye Defects. PLoS ONE.  ISSN 1932-6203.  5(11) . doi: 10.1371/journal.pone.0013827
  • Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO & Klungland, A (2010). Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology.  ISSN 0270-7306.  30(7), s 1814- 1827 . doi: 10.1128/MCB.01602-09
  • Robertson, AB; Klungland, A; Rognes, T & Leiros, Ingar (2009). DNA Repair in Mammalian Cells. Cellular and Molecular Life Sciences (CMLS).  ISSN 1420-682X.  66(6), s 981- 993 . doi: 10.1007/s00018-009-8736-z
  • Van den Born, Erwin; Bekkelund, Anders; Moen, Marivi; Omelchenko, M.V.; Klungland, Arne & Falnes, Pål (2009). Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria. Nucleic Acids Research.  ISSN 0305-1048.  37(21) . doi: 10.1093/nar/gkp774
  • Larsen, Elisabeth; Kleppa, Liv; Meza, Trine Johansen; Meza, Zepeda Leonardo; Rada, C; Castellanos, Cesilie Granum; Lien, Guro Flor; Nesse, Gaute; Neuberger, MS; Lærdahl, Jon Kristen; Doughty, RW & Klungland, Arne (2008). Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants. Cancer Research.  ISSN 0008-5472.  68, s 4571- 4579 . doi: 10.1158/0008-5472.CAN-08-0168
  • Ringvoll, Jeanette; Moen, Marivi N.; Nordstrand, Line M.; Meira, Lisiane B.; Pang, Bo; Bekkelund, Anders; Dedon, Peter C.; Bjelland, Svein; Samson, Leona D.; Falnes, Pål Ø. & Klungland, Arne (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research.  ISSN 0008-5472.  68(11), s 4142- 4149 Vis sammendrag
  • Saxowsky, TT; Meadows, KL; Klungland, Arne & Doetsch, PW (2008). 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  105(48), s 18877- 18882 . doi: 10.1073/pnas.0806464105
  • Wærsted, Jeanette Ringvoll; Nabong, Marivi; Nordstrand, Line Mari; Meira, LB; Pang, B; Bekkelund, Anders; Dedon, PC; Bjelland, S; Samson, LD; Falnes, Pål & Klungland, Arne (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research.  ISSN 0008-5472.  68(11), s 4142- 4149 . doi: 10.1158/0008-5472.CAN-08-0796 Vis sammendrag
  • Falnes, Pål; Klungland, Arne & Alseth, Ingrun (2007). Repair of methyl lesions in DNA and RNA by oxidative demethylation. Neuroscience.  ISSN 0306-4522.  145 . doi: 10.1016/j.neuroscience.2006.11.018
  • Kleppa, Liv; Kanavin, Øivind Juris; Klungland, Arne & Strømme, Petter (2007). A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome. Neuroscience.  ISSN 0306-4522.  4, s 1397- 1406 . doi: 10.1016/j.neuroscience.2006.09.025
  • Klungland, Arne & Bjelland, Svein (2007). Oxidative damage to purines in DNA: Role of mammalian Ogg1. DNA Repair.  ISSN 1568-7864.  6 Vis sammendrag
  • Klungland, Arne; Lærdahl, Jon Kristen & Rognes, Torbjørn (2007). OGG1: From Structural Analysis to the Knockout Mouse, In Mark D. Evans & Marcus S. Cooke (ed.),  Oxidative Damage to Nucleic Acids.  Springer Science+Business Media B.V..  ISBN 9780387729732.  Chapter 5.  s 67 - 80
  • Kovtun, IV; Liu, Y; Bjørås, Magnar; Klungland, Arne; Wilson, SH & McMurray, CT (2007). OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature.  ISSN 0028-0836.  447 . doi: 10.1038/nature05778
  • Larsen, E; Meza, TJ; Kleppa, L & Klungland, Arne (2007). Organ and cell specificity of base excision repair mutants in mice. Mutation research.  ISSN 0027-5107.  614, s 56- 68 . doi: 10.1016/j.mrfmmm.2006.01.023
  • Leiros, Ingar; Nabong, Marivi P.; Grøsvik, Kristin; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Reite, Karen; Olsbu, Inger K.; Knævelsrud, I.; Moe, Elin; Andersen, Ole A.; Birkeland, Nils-Kåre; Ruoff, Peter; Klungland, Arne & Bjelland, Svein (2007). Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal.  ISSN 0261-4189.  26 Vis sammendrag
  • Leiros, Ingar; Nabong, Marivi; Nabong, MP; Grosvik, K; Grøsvik, Kristin; Ringvoll, J; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Uldal, L; Reite, K; Olsbu, IK; Knævelsrud, Ingeborg; Knaevelsrud, I; Moe, Elin; Andersen, Ole Andreas; Birkeland, NK; Ruoff, P; Klungland, A & Bjelland, S (2007). Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal.  ISSN 0261-4189.  26 . doi: 10.1038/sj.emboj.7601662
  • Nordstrand, Line Mari; Ringvoll, Jeanette; Larsen, Elisabeth & Klungland, Arne (2007). Genome instability and DNA damage accumulation in gene-targeted mice. Neuroscience.  ISSN 0306-4522.  145 . doi: 10.1016/j.neuroscience.2006.10.059
  • Ringvoll, Jeanette; Uldal, Lene; Røed, Marie Aslaksen; Stenersen, Karen Oppland; Baynton, K; Klungland, Arne & Eide, Lars (2007). Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol. FEMS yeast research (Print).  ISSN 1567-1356.  7, s 848- 859 . doi: 10.1111/j.1567-1364.2007.00248.x
  • Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB; Talstad, Vivi; Reite, Karen; Aas, Per Arne; Lauritzen, Knut H.; Liabakk, Nina-Beate; Bjørk, Alexandra; Doughty, Richard William; Falnes, Pål Ø.; Krokan, Hans Einar & Klungland, Arne (2006). Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal.  ISSN 0261-4189.  25, s 2189- 2198
  • Kleppa, Liv; Kanavin, Ø.J; Klungland, Arne & Strømme, Petter (2006). A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome. Neuroscience.  ISSN 0306-4522. . doi: 10.1016/j.neuroscience
  • Larsen, Elisabeth; Stenersen, Karen Oppland; Nesse, Gaute; Neurauter, Christine Gran; Seeberg, Erling Christen & Klungland, Arne (2006). Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1(-/-) mice. Oncogene.  ISSN 0950-9232.  25, s 2425- 2432
  • Touati, E; Michel, V; Thiberge, JM; Ave, P; Huerre, M; Bourgade, F; Klungland, Arne & Labigne, A (2006). Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H-Pylori infection in mouse. Helicobacter.  ISSN 1083-4389.  11, s 494- 505
  • Holen, Torgeir; Moe, Svein Erik E; Sørbø, Jan Gunnar; Meza, Trine Johansen; Ottersen, Ole Petter & Klungland, Arne (2005). Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo. Nucleic Acids Research.  ISSN 0305-1048.  33(15), s 4704- 4710 . doi: 10.1093/nar/gki785
  • Rozalski, R; Siomek, A; Gackowski, D; Foksinski, M; Gran, C; Klungland, Arne & Olinski, R (2005). Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice. International Journal of Biochemistry and Cell Biology.  ISSN 1357-2725.  37
  • Rozalski, R; Siomek, A; Gackowski, D; Gran, Christine; Foksinski, M; Gran, C; Klungland, Arne & Olinski, R (2004). Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine. Free radical research.  ISSN 1071-5762.  38(11), s 1201- 1205
  • Foksinski, M; Rozalski, R; Guz, J; Ruszkowska, B; Sztukowska, P; Piwowarski, M; Klungland, Arne & Olinski, R (2004). Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species. Free Radical Biology & Medicine.  ISSN 0891-5849.  37(9), s 1449- 1454
  • Larsen, E; Kwon, K; Coin, F; Egly, JM & Klungland, Arne (2004). Transcription activities at 8-oxoG lesions in DNA. DNA Repair.  ISSN 1568-7864.  3(11), s 1457- 1468
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Knævelsrud, Ingeborg; Kristoffersen, Wenche; Bjørås, M.; Robb, F.T.; Klungland, Arne & Bjelland, Svein (2002). Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus. Biochemistry.  ISSN 1520-4995.  41, s 12697- 12705
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Knævelsrud, Ingeborg; Kristoffersen, Wenche; Bjørås, M.; Robb, F.T.; Klungland, Arne & Bjelland, Svein (2002). Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus. Biochemistry.  ISSN 1520-4995.  41, s 12697- 12705
  • Bjelland, Svein; Klungland, Arne; Paulsen, R.; Rolseth, V.; Yamada, Y.; Ueno, Y.; Wiik, P.; Matsuda, A. & Seeberg, E. (2001). 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism. Toxicology Letters.  ISSN 0378-4274.  119, s 71- 78
  • Klungland, Helge & Klungland, Arne (2000). År 2000-2100: Genetikkens århundre?. Kirke og kultur.  ISSN 0023-186X.  105(05.jun), s 461- 476

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  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn; Klungland, Arne & Bjelland, Svein (2017). hSMUG1 is a bi-functional DNA glycosylase.
  • Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein (2017). Repair of double methylated bases in DNA.
  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn; Klungland, Arne & Bjelland, Svein (2016). hSMUG1-catalysed uracil-DNA strand incision.
  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn; Klungland, Arne & Bjelland, Svein (2016). hSMUG1-catalysed uracil-DNA strand incision.
  • Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein (2016). Repair of double methylated bases in DNA.
  • Catterall, Tara Cherie; Johnson, Inna; Khan, Shaista; Jermstad, Ingunn; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2015). The Norwegian Transgenic Centre.
  • Khan, Shaista; Jermstad, Ingunn; Catterall, Tara Cherie; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2014). The Norwegian Transgenic Centre.
  • Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne & Amdam, Gro Vang (2014). Epigenetically modified cytosines in the honey bee genome.
  • Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne & Amdam, Gro Vang (2013). Presence of modified cytosines in the honey bee genome.
  • Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fu, Ye & Klungland, Arne (2013). Sprouts of RNA epigenetics The discovery of mammalian RNA demethylases. RNA Biology.  ISSN 1547-6286.  10(6), s 915- 918 . doi: 10.4161/rna.24711
  • Warken, D.; Khobta, Andriy; Klungland, Arne & Epe, B. (2010). Flap endonuclease 1 (FEN-1) takes part in repair of DNA single-strand breaks. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  381, s 73- 73
  • Falnes, Pål; Van den Born, Erwin; Leihne, VIbeke; Meza, Trine Johansen; Songe-Møller, Lene & Klungland, Arne (2009). AlkB-like dioxygenases-roles in nucleic acid repair and modification.
  • Klungland, Arne & Andersson, Kristin Brevik (2007). Nobelpris for genmodifisering. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  23, s 127- 127
  • Leiros, Ingar; Nabong, Marivi P.; Haugland, GT; Ringvoll, Jeanette; Grøsvik, K; Grøsvik, K; Moe, Elin; Knævelsrud, I.; Knævelsrud, I.; Reite, Karen; Andersen, Ole A.; Birkeland, Nils-Kåre; Klungland, Arne; Bjelland, Svein & Bjelland, Svein (2006). Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus.
  • Trapp, C; Klungland, Arne & Epe, B (2006). The peroxisome proliferator WY-14,643 does not induce oxidative DNA damage in repair-deficient Csb(-/-)Ogg1(-/-) knockout mice. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  372, s 112- 112
  • Meza, Trine Johansen; Elisabeth, Larsen; Nesse, Gaute & Klungland, Arne (2005). Knock-down studies of FEN1 by gene targeting and RNAi.
  • Meza, Trine Johansen; Elisabeth, Larsen; Halsne, Ruth & Klungland, Arne (2004). Knock-down studies of FEN1 by gene targeting and RNAi.
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Kristoffersen, Wenche; Knævelsrud, Ingeborg; Bjørås, M.; Klungland, Arne; Robb, F.T. & Bjelland, Svein (2002). Cold-active methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Kristoffersen, Wenche; Knævelsrud, Ingeborg; Bjørås, M.; Klungland, Arne; Robb, F.T. & Bjelland, Svein (2002). Cold-active methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.
  • Klungland, Arne; Klungland, Helge & Kjær, Jan Erik (1998). Derfor er dyrene forskjellige. Buskap.  ISSN 0007-7194.  50(4), s 10- 11
  • Klungland, Helge; Klungland, Arne & Kjær, Jan Erik (1998). Gener i avlsarbeidet. Buskap.  ISSN 0007-7194.  50(5), s 20- 22
  • Klungland, Helge; Klungland, Arne & Kjær, Jan Erik (1998). Gener og kromosomer. Buskap.  ISSN 0007-7194.  50(3), s 36- 37

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Publisert 13. apr. 2011 10:38 - Sist endret 16. okt. 2017 22:25

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