This platform develops standardized iPS derived organotypic structures with key attributes of the organ being modeled.
iPSC-derived liver spheroids expressing albumin and HNF4a.
We are developing standardized functionally validated organotypic structures, with in vivo attributes of the organs being modeled. Organoids are derived from human induced pluripotent stem cells by directed differentiation to core functional unit(s) of the organ and benchmarked to human organ tissue. Organoids are grown in modular fluidic “containers”, providing easy handling and allowing versatile modular combinations on the “organ on a chip” platform. Our main focus is on hepatic, islet and adipocyte organoids.