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Published May 19, 2021 1:13 PM

An updated suite of viral vectors for in vivo calcium imaging using local and retro-orbital injections

We show that systemic injections of PHP.eB AAVs to express GECIs is a highly promising technique for imaging neural activity and circumvent the need for transgenic GECI expressing mouse lines. We also establish the use of novel soma-targeted GECIs that outperform current Ca2+ indicators using both systemic and local virus injections.