Xenobiotics og metabolisme
Since the 60-70ies, thousands of man-made chemicals have been created and manufactured. Xenobiotics (i.e. chemicals that cannot be produced naturally) have thus invaded our ecosystem and humans are daily and chronically exposed to a great number of xenobiotics throughout their lifespan.
By studying xenobiotics signaling and receptors involved in their detoxification, the Ruzzin laboratory aims to discover novel mechanisms involved in metabolism homeostasis and inflammation. We use engineered mouse models and organ/cell culture with cutting-edge biochemistry tools. In addition, we use human cohorts/samples to further determine the relevance of our experimental research.
►INSULIN RESISTANCE AND INFLAMMATION: We are interested by understanding how persistent organic pollutants (POPs) disrupt the insulin signaling pathway and contribute to the development of type 2 diabetes. We are currently investigating whether POPs and xenobiotics signaling can trigger intestinal inflammation.
Selected publications: Ruzzin J et al Environmental Health Perspectives 118:465-471, 2010. Ibrahim MM et al PLoS ONE 6(9): e25170, 2011. Gauthier MS, et al. Journal of Clinical Endocrinology & Metabolism 99:E1061-E1066, 2014. Heindel JJ, et al. Environmental Health 14, 2015. Dusanov S et al. Nutrition, Metabolism & Cardiovascular Diseases 28:735-742, 2018.
►FGF19 AND SKELETAL MUSCLE: Our investigations on xenobiotics signaling led us to study a potential role of the fibroblast growth factor 19 (FGF19) on skeletal muscle. We are investigating how FGF19 and its signaling can affect skeletal muscle growth and the musculoskeletal system.
Selected publications: Benoit et al. Nature Medicine 23:990-996, 2017.