Michael Rory Daws

Professor - Seksjon for anatomi
Bilde av Michael Rory Daws
English version of this page
Telefon +47 22851151
Rom 2503
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 Oslo
Postadresse Postboks 1105 Blindern 0317 Oslo

Arbeidsområder

  • Undervisning i modul-1 og modul-2:
    • immunologi
    • cellebiologi
    • histologi
    • anatomi
  • Forskning
    • reseptorer av det medfødte immunsystemet, og deres rolle i autoimmunitet og kreft

Bakgrunn

Jeg fullførte doktorgrad ved "University of Newcastle-upon-Tyne" i 1995. Første postdoc-periode var i Umeå, hvor jeg jobbet med NK-celler under veiledning av Charles Sentman. Deretter ble det 6 år i San Francisco i laben til Bill Seaman, før jeg flyttet til Oslo i 2004. Her har jeg forsket sammen med Bent Rolstad, John Torgils Vaage, Erik Dissen, og Sigbjørn Fossum. Siden 2015 har jeg hatt fast stilling som professor i anatomi.

Publikasjoner

  • Blankson, Vera; Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2022). Human macrophage C-type lectin forms a heteromeric receptor complex with Mincle but not Dectin-2. Scandinavian Journal of Immunology. ISSN 0300-9475. 95(5). doi: 10.1111/sji.13149.
  • N'Diaye, Marie; Brauner, Susanna; Flytzani, Sevasti; Kular, Lara; Warnecke, Andreas & Adzemovic, Milena Z. [Vis alle 22 forfattere av denne artikkelen] (2020). C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation. Journal of Clinical Investigation. ISSN 0021-9738. 130(2), s. 838–852. doi: 10.1172/JCI125857. Fulltekst i vitenarkiv
  • Daws, Michael Rory; Nakken, Britt; Lobato Pascual, Ana; Regis, Josien; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat . Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01060.
  • Daws, Michael Rory; Nakken, Britt; Lobato, Pascual Ana; Josien, Regis; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With Fc?RI? and Is Expressed by Myeloid Cell Subsets in the Rat. Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01060. Fulltekst i vitenarkiv
  • Bjørnsen, Elisabeth Gyllensten; Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Henden, Camilla; Sæther, Per Christian & Boysen, Preben [Vis alle 8 forfattere av denne artikkelen] (2019). B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines. European Journal of Immunology. ISSN 0014-2980. 49(1), s. 54–65. doi: 10.1002/eji.201847746. Fulltekst i vitenarkiv
  • Jendresen, Charlotte Bille; Daws, Michael Rory & Nilsson, Lars (2018). An improved CPRG colorimetric ligand-receptor signal transduction assay based on beta-galactosidase activity in mammalian BWZ-reporter cells. Journal of pharmacological and toxicological methods. ISSN 1056-8719. 90, s. 67–75. doi: 10.1016/j.vascn.2017.11.004. Fulltekst i vitenarkiv
  • Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian; Bjørnsen, Elisabeth Gyllensten; Pende, Daniela & Fossum, Sigbjørn [Vis alle 8 forfattere av denne artikkelen] (2017). The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer Cells. Journal of Immunology. ISSN 0022-1767. 198(7), s. 2556–2567. doi: 10.4049/jimmunol.1600930.
  • Jendresen, Charlotte Bille; Årskog, Vibeke Helen; Daws, Michael Rory & Nilsson, Lars (2017). The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. Journal of Neuroinflammation. ISSN 1742-2094. 14:59, s. 1–13. doi: 10.1186/s12974-017-0835-4.
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology. ISSN 0014-2980. 43(12), s. 3167–3174. doi: 10.1002/eji.201343752.
  • Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik & Fossum, Sigbjørn [Vis alle 7 forfattere av denne artikkelen] (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLOS ONE. ISSN 1932-6203. 8(2). doi: 10.1371/journal.pone.0057406.
  • Daws, Michael Rory; Dai, Kezheng; Zinöcker, Severin; Naper, Christian; Kveberg, Lise & Hedrich, Hans J [Vis alle 8 forfattere av denne artikkelen] (2012). Identification of an MHC Class I Ligand for the Single Member of a Killer Cell Lectin-like Receptor Family, KLRH1. Journal of Immunology. ISSN 0022-1767. 189(11), s. 5178–5184. doi: 10.4049/jimmunol.1201983.
  • Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics. ISSN 0093-7711. 63(12), s. 809–820. doi: 10.1007/s00251-011-0553-5.
  • Shegarfi, Hamid; Dai, Kezheng; Daws, Michael Rory; Ryan, James C.; Vaage, John Torgils & Rolstad, Bent [Vis alle 7 forfattere av denne artikkelen] (2011). The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages. Journal of Leukocyte Biology. ISSN 0741-5400. 89(4), s. 617–623. doi: 10.1189/jlb.1010593.
  • Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics. ISSN 0093-7711. 62(8), s. 521–530. doi: 10.1007/s00251-010-0455-y.
  • Kveberg, Lise; Dai, Kezheng; Westgaard, Ingunn Hagen; Daws, Michael Rory; Fossum, Sigbjørn & Naper, Christian [Vis alle 7 forfattere av denne artikkelen] (2009). Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. European Journal of Immunology. ISSN 0014-2980. 39(2), s. 541–551. doi: 10.1002/eji.200838891.
  • Humphrey, MB; Daws, Michael Rory; Spusta, SC; Niemi, EC; Torchia, JA & Lanier, LL [Vis alle 8 forfattere av denne artikkelen] (2006). TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Journal of Bone and Mineral Research. ISSN 0884-0431. 21.
  • Humphrey, MB; Daws, Michael Rory; Spusta, SC; Niemi, EC; Torchia, JA & Lanier, LL [Vis alle 8 forfattere av denne artikkelen] (2006). TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Journal of Bone and Mineral Research. ISSN 0884-0431. 21, s. 237–245.
  • Chen, TT; Li, L; Chung, DH; Allen, CDC; Torti, SV & Torti, FM [Vis alle 13 forfattere av denne artikkelen] (2005). TIM-2 is expressed on B-cells and in liver and kidney, and is a receptor for H-ferritin endocytosis. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 202, s. 955–965.
  • Humphrey, MB; Ogasawara, K; Yao, W; Spusta, SC; Daws, Michael Rory & Lane, NE [Vis alle 8 forfattere av denne artikkelen] (2004). The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. Journal of Bone and Mineral Research. ISSN 0884-0431. 19, s. 224–234.
  • Chung, DH; Humphrey, MB; Nakamura, MC; Seaman, WE & Daws, Michael Rory (2003). CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Journal of Immunology. ISSN 0022-1767. 171, s. 6541–6548.
  • Daws, Michael Rory; Sullam, PM; Niemi, EC; Chen, TT & Seaman, WE (2003). Pattern recognition by TREM-2: binding of anionic ligands. Journal of Immunology. ISSN 0022-1767. 171, s. 594–599.
  • Chung, DH; Seaman, WE & Daws, Michael Rory (2002). Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. European Journal of Immunology. ISSN 0014-2980. 32, s. 59–66.
  • O'Connell, D; Becerril, B; Roy-Burman, A; Daws, Michael Rory & Marks, JD (2002). Phage versus phagemid libraries for generation of human monoclonal antibodies. Journal of Molecular Biology (JMB). ISSN 0022-2836. 321, s. 49–56.
  • Ryan, JC; Naper, Christian; Hayashi, Shigenari & Daws, Michael Rory (2001). Physiologic functions of activating natural killer (NK) complex-encoded receptors on NK cells. Immunological Reviews. ISSN 0105-2896. 181, s. 126–137.
  • Karnbach, Claudia; Daws, Michael Rory; Niemi, EC & Nakamura, MC (2001). Immune rejection of a large sarcoma following cyclophosphamide and IL-12 treatment requires both NK and NK T cells and is associated with the induction of a novel NK T cell population. Journal of Immunology. ISSN 0022-1767. 167, s. 2569–2576.
  • Daws, Michael Rory; Lanier, LL; Seaman, WE & Ryan, JC (2001). Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. European Journal of Immunology. ISSN 0014-2980. 31, s. 783–791.
  • Daws, Michael Rory; Eriksson, Mikael; Öberg, Linda; Ullén, Anders & Sentman, Charles L (1999). H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology. ISSN 0019-2805. 97, s. 656–664.
  • Westley, BR; Clayton, SJ; Daws, Michael Rory; Molloy, CA & May, FE (1998). Interactions between the oestrogen and insulin-like growth factor signalling pathways in the control of breast epithelial cell proliferation. Biochemical Society Symposium. ISSN 0067-8694. 63, s. 35–44.
  • Cilio, CM; Daws, Michael Rory; Malashicheva, A; Sentman, Charles L & Holmberg, D (1998). Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 188, s. 1239–1246.
  • Fahlén, Linda; Khoo, NK; Daws, Michael Rory & Sentman, Charles L (1997). Location-specific regulation of transgenic Ly49A receptors by major histocompatibility complex class I molecules. European Journal of Immunology. ISSN 0014-2980. 27, s. 2057–2065.
  • Daws, Michael Rory; Westley, BR & May, FE (1996). Paradoxical effects of overexpression of the type I insulin-like growth factor (IGF) receptor on the responsiveness of human breast cancer cells to IGFs and estradiol. Endocrinology. ISSN 0013-7227. 137, s. 1177–1186.

Se alle arbeider i Cristin

  • Nakken, Britt; Jensen, Wendi; Szodoray, Peter; Daws, Michael Rory & Fossum, Sigbjørn (2011). Role of the C-Type Lectin-Like Receptor Dcar1 in Oil Induced Arthritis. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s. 375–376.
  • Dahle, Maria Krudtaa & Daws, Michael Rory (2010). Regulation of activating CD300-receptors in human macrophage differentiation and inflammatory activation.
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn & Daws, Michael Rory (2010). Exploring expression and function of the rat Macrophage C-type Lectin, Clecsf8.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn & Naper, Christian [Vis alle 7 forfattere av denne artikkelen] (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin-related molecules.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn & Naper, Christian [Vis alle 7 forfattere av denne artikkelen] (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin related molecules.
  • Zinöcker, Severin; Dai, Kezheng; Naper, Christian; Daws, Michael Rory; Rolstad, Bent & Vaage, John Torgils (2007). A novel reporter system to identify NK receptor-MHC ligand interactions.
  • Daws, Michael Rory; Dai, K; Naper, C; Rolstad, Bent & Vaage, JT (2006). Identification of an MHC ligand for the rat natural killer cell receptor KLRH1. Tissue Antigens. ISSN 0001-2815. 67, s. 444–445.
  • Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth & Flornes, Line Mari [Vis alle 9 forfattere av denne artikkelen] (2011). Oljer og helse - et pilotprosjekt. Kartlegging av oljeeksponering, genetiske faktorer og sykdom hos pasienter som ble utredet for mulig arbeidsrelatertsykdom. Statens Arbeidsmiljøinstitutt. ISSN 1502-0932. Årgang 12(Nr. 1).

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Publisert 13. apr. 2011 10:35 - Sist endret 29. apr. 2021 10:40