Camilla Schjalm

• Gramstad, Olav Rogde; Schjalm, Camilla; Mollnes, Tom Eirik & Nielsen, Erik Waage (2023). Increased thromboinflammatory load in hereditary angioedema. Clinical and Experimental Immunology. ISSN 0009-9104. 214(2), s. 170–181. doi: 10.1093/cei/uxad091. Fulltekst i vitenarkiv
• Thorgersen, Ebbe Billmann; Asvall, Jørund; Schjalm, Camilla; Ekholt, Karin; Bruland, Øyvind & Larsen, Stein Gunnar [Vis alle 7 forfattere av denne artikkelen] (2023). Effect of Intraperitoneal ²²⁴Radium-Labelled Microparticles on Compartmentalized Inflammation After Cytoreductive Surgery and Hypertherm Intraperitoneal Chemotherapy. Technology in Cancer Research & Treatment (TCRT). ISSN 1533-0346. 22. doi: 10.1177/15330338231192902. Fulltekst i vitenarkiv
• Torp, May-Kristin; Ranheim, Trine; Schjalm, Camilla; Hjorth, Marit; Heiestad, Christina Mathisen & Dalen, Knut Tomas [Vis alle 13 forfattere av denne artikkelen] (2022). Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis. Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.870811. Fulltekst i vitenarkiv Vis sammendrag

  The innate immune system is rapidly activated during myocardial infarction and blockade of extracellular complement system reduces infarct size. Intracellular complement, however, appears to be closely linked to metabolic pathways and its role in ischemia-reperfusion injury is unknown and may be different from complement activation in the circulation. The purpose of the present study was to investigate the role of intracellular complement in isolated, retrogradely buffer-perfused hearts and cardiac cells from adult male wild type mice (WT) and from adult male mice with knockout of complement component 3 (C3KO). Main findings: (i) Intracellular C3 protein was expressed in isolated cardiomyocytes and in whole hearts, (ii) after ischemia-reperfusion injury, C3KO hearts had larger infarct size (32 ± 9% in C3KO vs. 22 ± 7% in WT; p=0.008) and impaired post-ischemic relaxation compared to WT hearts, (iii) C3KO cardiomyocytes had lower basal oxidative respiration compared to WT cardiomyocytes, (iv) blocking mTOR decreased Akt phosphorylation in WT, but not in C3KO cardiomyocytes, (v) after ischemia, WT hearts had higher levels of ATP, but lower levels of both reduced and oxidized nicotinamide adenine dinucleotide (NADH and NAD+, respectively) compared to C3KO hearts. Conclusion: intracellular C3 protected the heart against ischemia-reperfusion injury, possibly due to its role in metabolic pathways important for energy production and cell survival.

• Coelho Medeiros, Pedro Miguel; Schjalm, Camilla; Christiansen, Dorte; Sokolova, Marina; Pischke, Soeren Erik & Würzner, Reinhard [Vis alle 8 forfattere av denne artikkelen] (2021). Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus - When Incubated in Human Whole Blood. Shock. ISSN 1073-2322. 57(1), s. 72–80. doi: 10.1097/SHK.0000000000001834. Fulltekst i vitenarkiv
• Holt, Margrethe Flesvig; Michelsen, Annika Elisabet; Shahini, Negar; Bjørkelund, Elisabeth; Bendz, Christina & Massey, Richard J [Vis alle 15 forfattere av denne artikkelen] (2021). The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.800978. Fulltekst i vitenarkiv
• Thomas, Anub Mathew; Chaban, Viktoriia; Pischke, Soeren; Orrem, Hilde Lang; Bosnes, Vidar & Sunde, Kjetil [Vis alle 13 forfattere av denne artikkelen] (2021). Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically. Molecular Immunology. ISSN 0161-5890. 141, s. 273–279. doi: 10.1016/j.molimm.2021.11.016. Fulltekst i vitenarkiv
• Chaban, Viktoriia; Nakstad, Espen R.; Stær-Jensen, Henrik; Schjalm, Camilla; Seljeflot, Ingebjørg & Vaage, Ingvar Jarle [Vis alle 12 forfattere av denne artikkelen] (2021). Complement activation is associated with poor outcome after out-of-hospital cardiac arrest. Resuscitation. ISSN 0300-9572. 166, s. 129–136. doi: 10.1016/j.resuscitation.2021.05.038. Fulltekst i vitenarkiv
• Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver & Pischke, Soeren [Vis alle 15 forfattere av denne artikkelen] (2021). A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity. Journal of Immunology. ISSN 0022-1767. 207(6), s. 1641–1651. doi: 10.4049/jimmunol.2001471. Fulltekst i vitenarkiv
• Storm, Benjamin; Halvorsen, Per Steinar; Skulstad, Helge; Dybwik, Knut Gustav; Schjalm, Camilla & Christiansen, Dorte [Vis alle 11 forfattere av denne artikkelen] (2021). Open chest and pericardium facilitate transpulmonary passage of venous air emboli. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 65(5), s. 648–655. doi: 10.1111/aas.13796. Fulltekst i vitenarkiv
• Sundnes, Olav; Ottestad, William Arne; Schjalm, Camilla; Lundbäck, Peter; La Cour Poulsen, Lars & Mollnes, Tom Eirik [Vis alle 8 forfattere av denne artikkelen] (2021). Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study. Molecular medicine (Cambridge, Mass. Print). ISSN 1076-1551. 27:29, s. 1–10. doi: 10.1186/s10020-021-00288-1. Fulltekst i vitenarkiv
• Thorgersen, Ebbe Billmann; Asvall, Jørund; Frøysnes, Ida Storhaug; Schjalm, Camilla; Larsen, Stein Gunnar & Dueland, Svein [Vis alle 10 forfattere av denne artikkelen] (2021). Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Annals of Surgical Oncology. ISSN 1068-9265. doi: 10.1245/s10434-021-10022-0. Fulltekst i vitenarkiv
• Grinde, Dina Mikhailovna; Øverland, Torstein; Lima, Kari; Schjalm, Camilla; Mollnes, Tom Eirik & Abrahamsen, Tore G (2020). Complement Activation in 22q11.2 Deletion Syndrome. Journal of Clinical Immunology. ISSN 0271-9142. 40(3), s. 515–523. doi: 10.1007/s10875-020-00766-x. Fulltekst i vitenarkiv
• Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian & Pischke, Soeren [Vis alle 22 forfattere av denne artikkelen] (2020). Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19. Scientific Reports. ISSN 2045-2322. 10. doi: 10.1038/s41598-020-78710-7. Fulltekst i vitenarkiv
• Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne & Holten, Aleksander Rygh [Vis alle 32 forfattere av denne artikkelen] (2020). Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients . Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(40), s. 25018–25025. doi: 10.1073/pnas.2010540117. Fulltekst i vitenarkiv
• Shahini, Negar; Schjalm, Camilla; Nilsson, Per; Holt, Margrethe Flesvig; Øgaard, Jonas & Lien, Egil [Vis alle 12 forfattere av denne artikkelen] (2020). Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 523(4), s. 867–873. doi: 10.1016/j.bbrc.2020.01.018. Fulltekst i vitenarkiv
• Thomas, Anub Mathew; Schjalm, Camilla; Nilsson, Per; Lindenskov, Paal Helge H.; Rørtveit, Runa & Solberg, Rønnaug [Vis alle 15 forfattere av denne artikkelen] (2018). Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome. Neonatology. ISSN 1661-7800. 113(4), s. 322–330. doi: 10.1159/000486542. Fulltekst i vitenarkiv
• Genster, Ninette; Østrup, Olga; Schjalm, Camilla; Mollnes, Tom Eirik; Cowland, Jack B. & Garred, Peter (2017). Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-04121-w. Fulltekst i vitenarkiv
• Harboe, Morten; Johnson, Christina; Nymo, Stig Haugset; Ekholt, Karin; Schjalm, Camilla & Lindstad, Julie Katrine [Vis alle 11 forfattere av denne artikkelen] (2017). Properdin binding to complement activating surfaces depends on initial C3b deposition. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 114(4), s. E534–E539. doi: 10.1073/pnas.1612385114. Fulltekst i vitenarkiv
• Otterdal, Kari; Portillo, Aránzazu; Astrup, Elisabeth; Ludviksen, Judith K; Schjalm, Camilla & Raoult, Didier [Vis alle 12 forfattere av denne artikkelen] (2016). Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. Clinical Microbiology and Infection (CMI). ISSN 1198-743X. 22(8), s. 734.e1–734.e6. doi: 10.1016/j.cmi.2016.05.010. Fulltekst i vitenarkiv
• Nesset, Cecilie Kåsi; Kong, Xiang Yi; Damme, Markus; Schjalm, Camilla; Roos, Norbert & Løberg, Else Marit [Vis alle 7 forfattere av denne artikkelen] (2016). Age-dependent development of liver fibrosis in Glmp (gt/gt) mice. Fibrogenesis & Tissue Repair. ISSN 1755-1536. 9(5). doi: 10.1186/s13069-016-0042-4.
• Otterdal, Kari; Portillo, Aránzazu; Astrup, Elisabeth; Ludviksen, Judith K; Davi, Giovanni & Holm, Sverre [Vis alle 16 forfattere av denne artikkelen] (2016). High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation. Cytokine. ISSN 1043-4666. 83, s. 269–274. doi: 10.1016/j.cyto.2016.05.006. Vis sammendrag

  Background The pathophysiological hallmark of Rickettsia conorii (R. conorii) infection comprises infection of endothelial cells with perivascular infiltration of T-cells and macrophages. Although interferon (IFN)-γ-induced protein 10 (IP-10)/CXCL10 is induced during vascular inflammation, data on CXCL10 in R. conorii infection is scarce. Methods Serum CXCL10 was analyzed in two cohorts of southern European patients with R. conorii infection using multiplex cytokine assays. The mechanism of R. conorii-induced CXCL10 release was examined ex vivo using human whole blood interacting with endothelial cells. Results (i) At admission, R. conorii infected patients had excessively increased CXCL10 levels, similar in the Italian (n = 32, ∼56-fold increase vs controls) and the Spanish cohort (n = 38, ∼68-fold increase vs controls), followed by a marked decrease after recovery. The massive CXCL10 increase was selective since it was not accompanied with similar changes in other cytokines. (ii) Heat-inactivated R. conorii induced a marked CXCL10 increase when whole blood and endothelial cells were co-cultured. Even plasma obtained from R. conorii-exposed whole blood induced a marked CXCL10 release from endothelial cells, comparable to the levels found in serum of R. conorii-infected patients. Bacteria alone did not induce CXCL10 production in endothelial cells, macrophages or smooth muscle cells. Conclusions We show a massive and selective serum CXCL10 response in R. conorii-infected patients, likely reflecting release from infected endothelial cells characterized by infiltrating T cells and monocytes. The CXCL10 response could contribute to T-cell infiltration within the infected organ, but the pathologic consequences of CXCL10 in clinical R. conorii infection remain to be defined.

• Kong, Xiang Yi; Kase, Eili Tranheim; Herskedal, Anette; Schjalm, Camilla; Damme, Markus & Nesset, Cecilie Kåsi [Vis alle 9 forfattere av denne artikkelen] (2015). Lack of the lysosomal membrane protein, GLMP, in mice results in metabolic dysregulation in liver. PLOS ONE. ISSN 1932-6203. 10(6). doi: 10.1371/journal.pone.0129402. Fulltekst i vitenarkiv

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• van den Heuvel, Lambertus P.; van de Kar, Nicole C.A.J.; Duineveld, Caroline; Sarlea, Andrei; van der Velden, Thea J.A.M. & Liebrand, Wilhelmus T. B. [Vis alle 12 forfattere av denne artikkelen] (2020). The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment. Cellular & Molecular Immunology. ISSN 1672-7681. 17(6), s. 653–655. doi: 10.1038/s41423-020-0406-y.
• Siljan, William; Holter, Jan Cato; Nymo, Ståle Haugset; Schjalm, Camilla; Müller, Fredrik & Jenum, Pål [Vis alle 11 forfattere av denne artikkelen] (2016). Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome. Journal of Infection. ISSN 0163-4453. 73(4), s. 383–386. doi: 10.1016/j.jinf.2016.07.011.
• Kong, Xiang Yi; Nesset, Cecilie Kåsi; Schjalm, Camilla; Løberg, Else Marit; Rustan, Arild & Thoresen, G. Hege [Vis alle 8 forfattere av denne artikkelen] (2014). NCU-G1GT/GT MICE: A LONG-LIVED MODEL FOR LIVER FIBROSIS.

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