Bjørn Allan Moum

• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada C; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2020). Pain Severity and Vitamin D Deficiency in IBD Patients. Nutrients.  ISSN 2072-6643.  12(1), s 1- 12 . doi: 10.3390/nu12010026 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD. Keywords: pain severity; patient reported outcomes; vitamin D deficiency.

• Hedin, Charlotte Rose Hawkey; Sado, Gina; Ndegwa, Nelson; Lytvyak, Ellina; Mason, Andrew; Montano-Loza, Aldo; Gerussi, Alessio; Saffioti, Francesca; Thorburn, Douglas; Nilsson, Emma; Larsson, Geir; Moum, Bjørn; van Munster, Kim N.; Ponsioen, Cyriel Y.; Levy, Cynthia; Nogueira, Nicholas F.; Bowlus, Christopher; Gotlieb, Neta; Shibolet, Oren; Lynch, Kate D.; Chapman, Roger W.; Rupp, C.; Vesterhus, Mette; Jørgensen, Kristin Kaasen; Rorsman, Fredrik; Schramm, Christoph; Sabino, João; Vermeire, Severine; Zago, Alessandra; Cazzagon, Nora; Marschall, Hanns-Ulrich; Ytting, Henriette; Ben Belkacem, Karima; Chazouillères, Olivier; Almer, Sven & Bergquist, Annika (2020). Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis. Clinical Gastroenterology and Hepatology.  ISSN 1542-3565.  18(10), s 2295- 2304.e2 . doi: 10.1016/j.cgh.2020.02.014
• Jørgensen, Kristin Kaasen; Goll, Guro Løvik; Sexton, Joseph; Bolstad, Nils; Olsen, Inge Christoffer; Asak, Øivind Wessel; Berset, Ingrid Prytz; Blomgren, Ingrid; Dvergsnes, Katrine; Florholmen, Jon; Frigstad, Svein Oskar; Henriksen, Magne; Hagfors, Jon; Huppertz-Hauss, Gert; Haavardsholm, Espen Andre; Klaasen, Rolf; Moum, Bjørn; Noraberg, Geir; Prestegård, Ulf; Rydning, Jan Henrik; Sagatun, Liv; Seeberg, Kathrine; Torp, Roald; Vold, Cecilia; Warren, David; Ystrøm, Carl Magnus; Lundin, Knut Erik Aslaksen; Kvien, Tore Kristian & Jahnsen, Jørgen (2020). Efficacy and safety of CT-P13 in inflammatory bowel disease after switching from originator infliximab: Exploratory analyses from the NOR-SWITCH main and extension trials. BioDrugs.  ISSN 1173-8804.  34(5), s 681- 694 . doi: 10.1007/s40259-020-00438-7 Fulltekst i vitenarkiv. Vis sammendrag

  Background: The NOR-SWITCH main and extension trials demonstrated that switching from originator to biosimilar infliximab (CT-P13) is efficacious and safe across six diseases. However, a subgroup analysis of Crohn's disease (CD) in the main trial displayed a close to significant difference favouring originator infliximab, and more scientific data have therefore been requested. Objective: The aim was to assess treatment efficacy, safety, and immunogenicity in an explorative subgroup analysis in CD and ulcerative colitis (UC) in the NOR-SWITCH trials. Patients and methods: The 52-week, randomised, non-inferiority, double-blind, multicentre, phase 4 NOR-SWITCH study was followed by a 26-week open extension trial where all patients received treatment with CT-P13. Treatment efficacy, safety, and immunogenicity in CD and UC were assessed throughout the 78-week study period. Results: The main and extension trials included 155 and 93 patients with CD and 93 and 80 patients with UC, respectively. Demographic and baseline characteristics were comparable in both treatment arms within patient groups. There were no differences in the main and extension trials regarding changes in activity indices, C-reactive protein, faecal calprotectin, patient's and physician's global assessment of disease activity and patient-reported outcome measures in CD and UC. Moreover, comparable results were also demonstrated for trough serum levels, presence of anti-drug antibodies, and reported adverse events. Conclusion: Efficacy, safety, and immunogenicity of both the originator and biosimilar infliximab were comparable in CD and UC in the NOR-SWITCH main and extension trials. These explorative subgroup analyses confirm that there are no significant concerns related to switching from originator infliximab to CT-P13 in CD and UC.

• Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Småstuen, Milada Cvancarova; Hovde, Øistein; Henriksen, Magne; Huppertz-Hauss, Gert; Günther, Eva Haugset; Moum, Bjørn; Stray, Njaal; Vatn, Morten H; Høie, Ole Ingebreth & Jahnsen, Jørgen (2020). Outcome of Ulcerative Colitis 20 Years after Diagnosis in a Prospective Population-based Inception Cohort from South-Eastern Norway, the IBSEN Study. Journal of Crohn's and colitis.  ISSN 1873-9946. . doi: 10.1093/ecco-jcc/jjaa232 Fulltekst i vitenarkiv. Vis sammendrag

  Background and aims: The long-term course of ulcerative colitis [UC] is difficult to predict. Mortality, colectomy, cancer, and hospitalisation represent hard outcomes of disease. Moreover, knowledge on the risk of relapses and need for potent medication add important information about living with UC. We aimed to evaluate the course and prognosis of UC during the first 20 years after diagnosis, and to identify early prognostic risk factors. Methods: From 1990 to 1994, a population-based inception cohort of patients with inflammatory bowel disease was enrolled in South-Eastern Norway. A systematic follow-up [FU] was conducted at 1,5, 10, and 20 years after diagnosis. Clinical outcomes were recorded continuously, and possible relationships between early disease characteristics and outcomes were analysed using multiple regression analysis. Results: Among 519 UC patients, 119 died, 60 were lost to FU, and 340 were included in the FU cohort. The 20-year cumulative risk of colectomy was 13.0% (95% confidence interval [CI] [11.4-14.6]). Extensive colitis at diagnosis was independently associated with an increased risk of colectomy compared with proctitis (hazard ratio [HR] = 2].8, 95% CI [1.3-6.1]). In contrast, mucosal healing at 1-year FU was independently associated with reduced risk of colectomy [HR = 0.4, 95% CI [0.2-0.8]), and inversely associated with subsequent risk of relapse [adjusted HR = 0.5, 95% CI [0.3-0.7]). Conclusions: The overall risk of colectomy in our cohort was lower than expected from previous studies, although considerable for patients with extensive colitis at diagnosis. Early mucosal healing was associated with better disease outcomes 20 years after diagnosis.

• Klepp, Pasquale Catherine; Brackmann, Stephan; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Hovde, Øistein; Henriksen, Magne; Huppertz-Hauss, Gert; Bernklev, Tomm; Høie, Ole Ingebreth; Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Stray, Njaal; Jahnsen, Jørgen; Vatn, Morten H & Moum, Bjørn (2020). Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study. BMJ open gastroenterology.  ISSN 2054-4774.  7 . doi: 10.1136/bmjgast-2019-000361 Fulltekst i vitenarkiv. Vis sammendrag

  Objective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. In the present study, we evaluated clinical risk factors associated with CRC during a prescheduled follow-up 20 years after diagnosis, the IBSEN study. Design A population-based inception cohort of patients diagnosed with inflammatory bowel disease from 1 January 1990 until 31 December 1993, prospectively followed at 1, 5, 10 and 20 years after diagnosis. A total of 517 patients with UC were included; 264 (51 %) men; median age at inclusion 37.4 years (4–88). Results The overall incidence of CRC was 1.6% (8/517) at a 20-year follow-up. The total lifetime risk of CRC prior to or after UC diagnosis was 2.3%. (12/517). Patients older than 70 years at diagnosis had a 15-fold higher risk of CRC compared with those diagnosed when younger than 40 years, with HR 15.68 (95% CI: 1.31 to 187.92). Neither sex, first-degree relative with CRC, extent of colitis nor primary sclerosing cholangitis affected the risk of CRC. Conclusion The risk of CRC in UC was low and comparable with the risk of CRC in the background population of Norway.

• Kravdal, Øystein; Magnus, Per; Moum, Bjørn & Høivik, Marte Lie (2020). Association of Childbearing with a Short-Term Reduced Risk of Crohn Disease in Mothers. American Journal of Epidemiology.  ISSN 0002-9262.  189(4), s 294- 304 . doi: 10.1093/aje/kwz285 Fulltekst i vitenarkiv.
• Kravdal, Øystein; Magnus, Per; Moum, Bjørn & Høivik, Marte Lie (2020). Childbearing is Associated with a Short-term Reduced Risk of Crohn’s Disease in Mothers. American Journal of Epidemiology.  ISSN 0002-9262.  189(4), s 294- 304 . doi: https://doi.org/10.1093/aje/kwz285 Fulltekst i vitenarkiv.
• Kristensen, Vendel Ailin; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Moum, Bjørn & Vatn, Morten H (2020). Serological antibodies and surgery in a population-based inception cohort of Crohn's disease patients - the IBSEN study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521. . doi: 10.1080/00365521.2020.1745879
• Opheim, Randi; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Berset, Ingrid Prytz; Hovde, Øistein; Huppertz-Hauss, Gert; Bernklev, Tomm & Jelsness-Jørgensen, Lars-Petter (2020). Self-esteem in patients with inflammatory bowel disease. Quality of Life Research.  ISSN 0962-9343.  29, s 1839- 1846 . doi: 10.1007/s11136-020-02467-9 Fulltekst i vitenarkiv. Vis sammendrag

  Purpose The purpose of this study was to explore self-esteem and associations between self-esteem and sociodemographic, clinical, and psychological factors in patients with infammatory bowel disease (IBD), a disease of chronic relapsing infammation of the gastrointestinal tract. IBD symptoms, including pain, fatigue, and diarrhea, as well as potential life-long medical treatment and surgery, may be demanding, cause signifcant challenges, and infuence self-esteem. Methods In this cross-sectional multicenter study, participants were recruited from nine hospitals in the southeastern and western regions of Norway from March 2013 to April 2014. Data were collected using self-report questionnaires. Selfesteem was assessed by the Rosenberg Self-Esteem Scale, fatigue was assessed by the Fatigue Questionnaire, self-efcacy was assessed by the General Self-Efcacy Scale, and disease activity was assessed by the Simple Clinical Colitis Activity Index for ulcerative colitis (UC) and Harvey Bradshaw Index for Crohn’s disease (CD). Multiple linear regression analysis was applied to examine associations between self-esteem and sociodemographic, clinical, and psychological factors. Results In total, 411 of 452 (91%) patients had evaluable data and were included in this study. The mean scores on selfesteem, self-efcacy, total fatigue, anxiety, and depression were similar between UC patients and CD patients. Male gender, being employed, and higher self-efcacy were independently associated with higher self-esteem, whereas anxiety and depression were independently associated with lower self-esteem. Neither disease activity nor fatigue were associated with self-esteem in the fnal multiple regression analyses. Conclusion Patient-centered interventions that improve self-esteem and reduce anxiety and depression seem to be important to optimize IBD management. Keywords Self-esteem · Self-efcacy · Coping · Infammatory bowel disease · Ulcerative colitis · Crohn’s disease · Health psychology · Chronic disease · Health-related quality of life

• Ossum, Alvilde Maria; Palm, Øyvind; Småstuen, Milada C; Bernklev, Tomm; Jahnsen, Jørgen; Moum, Bjørn & Høivik, Marte Lie (2020). The Impact of Spondyloarthritis and Joint Symptoms on Health-Related Quality of Life and Fatigue in IBD Patients. Results from a Population-Based Inception Cohort (20-Year Follow-up in the Ibsen Study). Inflammatory Bowel Diseases.  ISSN 1078-0998. . doi: 10.1093/ibd/izz105 Fulltekst i vitenarkiv.
• Vesterhus, Mette; Nielsen, Mette; Hov, Johannes Espolin Roksund; Saffioti, Francesca; Manon-Jensen, Tina; Leeming, Diana Julie; Moum, Bjørn; Boberg, Kirsten Muri; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, Morten A & Thorburn, Douglas (2020). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. JHEP Reports.  3(1) . doi: https://doi.org/10.1016/j.jhepr.2020.100178 Fulltekst i vitenarkiv.
• Detlie, Trond Espen; Lindstrøm, Jonas Christoffer; Jahnsen, Marte Eide; Finnes, Elisabeth; Zoller, Heinz; Moum, Bjørn & Jahnsen, Jørgen (2019). Incidence of hypophosphatemia in patients with inflammatory bowel disease treated with ferric carboxymaltose or iron isomaltoside. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  50(4), s 397- 406 . doi: 10.1111/apt.15386 Fulltekst i vitenarkiv.
• Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia; Moum, Bjørn; Vesterhus, Mette; Karlsen, Tom Hemming; Seljeflot, Ingebjørg & Hov, Johannes Espolin Roksund (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print).  ISSN 1478-3223.  39(2), s 371- 381 . doi: 10.1111/liv.13979 Fulltekst i vitenarkiv.
• Goll, Guro Løvik; Jørgensen, Kristin Kaasen; Sexton, Joseph; Olsen, Inge Christoffer; Bolstad, Nils; Haavardsholm, Espen A.; Lundin, Knut Erik Aslaksen; Tveit, Kåre Steinar; Lorentzen, Merete; Berset, Ingrid Prytz; Fevang, Bjørg-Tilde Svanes; Kalstad, Synnøve; Ryggen, Kristin; Warren, David; Klaasen, Rolf; Asak, Øivind Wessel; Baig, Sarosh Sarmad Somyeh; Blomgren, Ingrid; Brenna, Øystein; Bruun, Trude J; Dvergsnes, Katrine; Frigstad, Svein Oskar; Myrnes, Inger; Hatten, Ingvild Helgheim; Huppertz-Hauss, Gert; Henriksen, Magne; Høie, Sunniva Skogstrøm; Krog, Jan; Midtgard, Irina P; Mielnik, Pawel; Moum, Bjørn; Noraberg, Geir; Poyan, Armin; Prestegård, Ulf; Rashid, Haroon Ur; Strand, Eldri Kveine; Skjetne, Kristine; Seeberg, Kathrine; Torp, Roald; Ystrøm, Carl Magnus; Vold, Cecilia; Zettel, Camilla; Waksvik, Kenneth; Gulbrandsen, Bjørn; Hagfors, Jon; Mørk, Cato; Jahnsen, Jørgen & Kvien, Tore Kristian (2019). Long‐term efficacy and safety of biosimilar infliximab (CT‐P13) after switching from originator infliximab: Open‐label extension of the NOR‐SWITCH trial. Journal of Internal Medicine.  ISSN 0954-6820.  285(6), s 653- 669 . doi: 10.1111/joim.12880 Fulltekst i vitenarkiv.
• Kisiel, John; Klepp, Pasquale Catherine; Allawi, Hatim T.; William, Taylor; Giakoumopoulos, Maria; Sander, Tamara; Yab, Tracy C.; Moum, Bjørn; Lidgard, Graham; Brackmann, Stephan; Mahoney, Douglas; Røseth, Arne & Ahlquist, David (2019). Analysis of DNA Methylation at Specific Loci in Stool Samples Detects Colorectal Cancer and High-Grade Dysplasia in Patients With Inflammatory Bowel Disease. Clinical Gastroenterology and Hepatology.  ISSN 1542-3565.  17(5), s 914- 921 . doi: 10.1016/j.cgh.2018.05.004
• Buer, Lydia Celine Tansem; Høivik, Marte Lie; Warren, David; Medhus, Asle Wilhelm & Moum, Bjørn (2018). Combining Anti-TNF-? and Vedolizumab in the Treatment of Inflammatory Bowel Disease: A Case Series. Inflammatory Bowel Diseases.  ISSN 1078-0998.  24(5), s 997- 1004 . doi: 10.1093/ibd/izx110 Vis sammendrag

  Background Anti-tumor necrosis factor α (anti-TNF-α) is important in the treatment of inflammatory bowel disease, but some patients experience only a partial response. In these patients, a combination of anti-TNF-α and vedolizumab (VDZ) may act as a bridge until the full VDZ effect occurs. At present, clinical data on combination treatment with anti-TNF-α and VDZ are not available. The aim of this case series was to evaluate the safety and clinical response of combination therapy with anti-TNF-α and VDZ in clinical practice. Methods All patients started on combination treatment with anti-TNF-α and VDZ from November 2015 to July 2016 were prospectively followed for at least 12 months. Results Six patients with ulcerative colitis and four patients with Crohn’s disease received combination treatment. These patients were followed for a median of 1712–20 months. No more adverse events than expected with anti-TNF-α alone were observed during combination treatment. At the end of follow-up, all patients were in clinical remission, and 8 patients could discontinue anti-TNF-α treatment and receive VDZ monotherapy. Two of the patients with Crohn’s disease required combination treatment throughout follow-up to obtain sustained remission. Conclusion Our findings suggest that combination treatment with anti TNF-α and VDZ is safe and might represent a long-term treatment option in selected patients.

• Buer, Lydia Celine Tansem; Moum, Bjørn; Småstuen, Milada Cvancarova; Warren, David; Bolstad, Nils; Medhus, Asle Wilhelm & Høivik, Marte Lie (2018). Real world data on effectiveness, safety and therapeutic drug monitoring of vedolizumab in patients with inflammatory bowel disease. A single center cohort. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  s 1- 9 . doi: 10.1080/00365521.2018.1548646
• Engebretsen, Kristin V Thunheim; Høgestøl, Ingvild Kristine; Hewitt, Stephen I; Risstad, Hilde; Moum, Bjørn; Kristinsson, Jon Adalsteinn & Mala, Tom (2018). Anemia following Roux-en-Y gastric bypass for morbid obesity; a 5-year follow-up study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  53(8), s 917- 922 . doi: 10.1080/00365521.2018.1489892
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada Cvancarova; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2018). Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  24(29), s 3293- 3301 . doi: 10.3748/wjg.v24.i29.3293
• Henriksen, Magne; Høivik, Marte Lie; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2018). Irritable bowel-like symptoms in ulcerative colitis are as common in patients in deep remission as with inflammation; results from a population-based study (the IBSEN study).. Journal of Crohn's and colitis.  ISSN 1873-9946.  12(4), s 389- 393 . doi: 10.1093/ECCO-JCC/JJX152
• Høivik, Marte Lie; Buer, Lydia Celine Tansem; Småstuen, Milada Cvancarova; Warren, David; Bolstad, Nils; Moum, Bjørn & Medhus, Asle Wilhelm (2018). Switching from originator to biosimilar infliximab?real world data of a prospective 18 months follow-up of a single-centre IBD population. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  53(6), s 692- 699 . doi: 10.1080/00365521.2018.1463391
• Klepp, Pasquale Catherine; Kisiel, John; Allawi, Hatim T; Taylor, William R; Giakoumopoulos, Maria; sander, Tamara; yab, tracy; Moum, Bjørn; Lidgard, Graham; Brackmann, Stephan; Mahoney, Douglas; Røseth, Arne & Ahlquist, David (2018). Analysis of DNA Methylation at Specific Loci in Stool Samples Detects Colorectal Cancer and High-grade Dysplasia in Patients with Inflammatory Bowel Disease.. Clinical Gastroenterology and Hepatology.  ISSN 1542-3565. . doi: 10.1016/j.cgh.2018.05.004.
• Klepp, Pasquale Catherine; Kisiel, John; Småstuen, Milada Cvancarova; Røseth, Arne; Andersen, Solveig Norheim; Vatn, Morten H; Ahlquist, David; Moum, Bjørn & Brackmann, Stephan (2018). Multi-target stool DNA test in the surveillance of inflammatory bowel disease: a cross-sectional cohort study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  53(3), s 273- 278 . doi: 10.1080/00365521.2018.1424935
• Klepp, Pasquale Catherine; Tollisen, Anita; Røseth, Arne; Småstuen, Milada Cvancarova; Andersen, Solveig Norheim; Vatn, Morten H; Moum, Bjørn & Brackmann, Stephan (2018). Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  24(35), s 4069- 4076 . doi: 10.3748/wjg.v24.i35.4069 Fulltekst i vitenarkiv.
• Lirhus, Sandre Svatun; Høivik, Marte Lie; Moum, Bjørn & Melberg, Hans Olav (2018). Regional differences in anti-TNF-a therapy and surgery in the treatment of inflammatory bowel disease patients: a Norwegian nationwide cohort study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  53(8), s 952- 957 . doi: 10.1080/00365521.2018.1495258 Fulltekst i vitenarkiv.
• Nielsen, MJ; Thorburn, Douglas; Leeming, DJ; Hov, Johannes Espolin Roksund; Nygård, Ståle; Moum, Bjørn; Saffioti, Francesca; Gilja, Odd Helge; Boberg, Kirsten Muri; Mazza, Giuseppe; Røsjø, Helge; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, MA & Vesterhus, Mette (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  48, s 179- 189 . doi: 10.1111/apt.14806
• Ossum, Alvilde Maria; Palm, Øyvind; Kapica, Aida; Småstuen, Milada C; BANITALEBI, HASAN; Negård, Anne; Høie, Ole Ingebreth; Henriksen, Magne; Moum, Bjørn & Høivik, Marte Lie (2018). Ankylosing Spondylitis and Axial Spondyloarthritis in Patients With Long-term Inflammatory Bowel Disease: Results From 20 Years of Follow-up in the IBSEN Study. Journal of Crohn's and colitis.  ISSN 1873-9946.  12(1), s 96- 104 . doi: 10.1093/ecco-jcc/jjx126
• Ossum, Alvilde Maria; Palm, Øyvind; Småstuen, Milada Cvancarova; Solberg, Inger Camilla; Vatn, Morten H; Moum, Bjørn & Høivik, Marte Lie (2018). Peripheral arthritis in patients with long-term inflammatory bowel disease. Results from 20 years of follow-up in the IBSEN study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  s 1- 8 . doi: 10.1080/00365521.2018.1518482 Vis sammendrag

  Objectives: Peripheral arthritis and related musculoskeletal manifestations, often classified as peripheral spondyloarthritis, are frequently seen in patients with inflammatory bowel disease (IBD). Few long-term studies have reported on the prevalence of these conditions. The aim of this study was to determine the prevalence of IBD-related peripheral arthritis and peripheral spondyloarthritis in IBD patients during 20 years of disease course, and to assess whether these conditions were associated with the intestinal IBD severity and activity. Materials and methods: In an inception cohort (the IBSEN study), IBD patients were followed prospectively for 20 years. At the 5 year follow-up the patients underwent a rheumatological examination and at the 20 year follow-up they completed a questionnaire with identical questions. When peripheral arthritis was characteristic and not explained by other specific diagnoses, it was defined as IBDrelated peripheral arthritis. The Assessment of Spondyloarthritis International Society criteria were used to define peripheral spondyloarthritis, including patients with peripheral arthritis, enthesitis and/ or dactylitis. Results: After 20 years of follow-up, 441 patients were included (296 ulcerative colitis and 145 Crohn’s disease). The prevalence of IBD-related peripheral arthritis was 17.2% and peripheral spondyloarthritis 27.9% during the disease course. IBD severity and activity were not different between those with a history of IBD-related peripheral arthritis or peripheral spondyloarthritis and those without. A higher proportion of women had IBD-related peripheral arthritis and peripheral spondyloarthritis. Conclusion: During 20 years of disease course, more than every sixth patient had suffered from IBDrelated peripheral arthritis and every fourth from peripheral spondyloarthritis.

• Shah, Shailja C.; Khalili, Hamed; Gower-Rousseau, Corinne; Olén, Ola; Benchimol, Eric I.; Lynge, Elsebeth; Nielsen, Kári R.; Brassard, Paul; Vutcovici, Maria; Bitton, Alain; Bernstein, Charles N.; Leddin, Desmond; Tamim, Hala; Stefansson, Tryggvi; Loftus, Edward V.; Moum, Bjørn; Tang, Whitney; Ng, Siew C.; Gearry, Richard; Sincic, Brankica; Bell, Sally; Sands, Bruce E.; Lakatos, Péter László; Végh, Zsuzsanna; Ott, Claudia; Kaplan, Gilaad G.; Burisch, Johan & Colombel, Jean-Frederic (2018). Sex-based differences in incidence of inflammatory bowel diseases-Pooled analysis of population-based studies from Western countries. Gastroenterology.  ISSN 0016-5085.  155(4), s 1079- 1089.e3 . doi: 10.1053/j.gastro.2018.06.043
• Siegel, Corey A.; Whitman, Cynthia B.; Spiegel, Brennan M.R.; Feagan, Brian; Sands, Bruce; Loftus, Edward V.; Panaccione, Remo; D'Haens, Geert; Bernstein, Charles N.; Gearry, Richard; Ng, Siew C.; Mantzaris, Gerassimos J.; Sartor, Balfour; Silverberg, Mark S.; Riddell, Robert; Koutroubakis, Ioannis E.; O'Morain, Colm; Lakatos, Péter László; McGovern, Dermot P.B.; Halfvarson, Jonas; Reinisch, Walter; Rogler, Gerhard; Kruis, Wolfgang; Tysk, Curt; Schreiber, Stefan; Danese, Silvio; Sandborn, William; Griffiths, Anne; Moum, Bjørn; Gasché, Christoph H.; Pallone, Francesco; Travis, Simon; Panes, Julian; Colombel, Jean-Frédéric; Hanauer, Stephen & Peyrin-Biroulet, Laurent (2018). Development of an index to define overall disease severity in IBD. Gut.  ISSN 0017-5749.  67(2), s 244- 254 . doi: 10.1136/gutjnl-2016-312648
• Buer, Lydia Celine Tansem; Høivik, Marte Lie; Medhus, Asle Wilhelm & Moum, Bjørn (2017). Does the Introduction of Biosimilars Change Our Understanding about Treatment Modalities for Inflammatory Bowel Disease?. Digestive Diseases.  ISSN 0257-2753.  35(1-2), s 74- 82 . doi: 10.1159/000449087
• Burisch, Johan; Vegh, Zsuzsanna; Katsanos, Konstantinos H.; Christodoulou, Dimitrios K.; Lazar, Daniela; Goldis, Adrian; O'Morain, Colm; Fernandez, Alberto; Pereira, Santos; Myers, Sally; Sebastian, Shaji; Pedersen, Natalia; Olse, Jóngerð; Nielsen, Kári Rubek; Schwartz, Doron; Odes, Selwyn; Almer, Sven; Halfvarson, Jonas; Turk, Niksa; Cukovic-Cavka, Silvja; Nikulina, Inna; Belousova, Elena; Duricova, Dana; Bortlik, Martin; Shonová, Olga; Salupere, Riina; Barros, Louisa; Magro, Fernando; Jonaitis, Laimas; Kupcinskas, Limas; Turcan, Svetlana; Kaimakliotis, Ioannis; Ladefoged, Karin; Kudsk, Karen; Andersen, Vibeke; Vind, Ida; Thorsgaard, Niels; Oksanen, Pia; Collin, Pekka; Dal Piaz, Giulia; Santini, Alessia; Niewiadomski, Ola; Bell, Sally; Moum, Bjørn; Arebi, Naila; Kjeldsen, Jens; Carlsen, Katrine; Langholz, Ebbe; Lakatos, Peter Laszlo; Munkholm, Pia; Gerdes, Lars Ulrik & Dahlerup, Jens Frederik (2017). Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort-An ECCO-EpiCom study. Journal of Crohn's and colitis.  ISSN 1873-9946.  11(10), s 1213- 1222 . doi: 10.1093/ecco-jcc/jjx077
• Frigstad, Svein Oskar; Høivik, Marte; Jahnsen, Jørgen; Dahl, Sandra Rinne; Småstuen, Milada C; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency in inflammatory bowel disease: Prevalence and predictors in a Norwegian outpatient population. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  52(1), s 100- 106 . doi: 10.1080/00365521.2016.1233577 Vis sammendrag

  Background and aim: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD. Methods: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory. Results: In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn’s disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency. Conclusions: Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity.

• Huppertz-Hauss, Gert; Høivik, Marte; Jelsness-Jørgensen, Lars-Petter; Opheim, Randi; Henriksen, Magne; Høie, Ole Ingebreth; Hovde, Øistein; Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Jahnsen, Jørgen; Hoff, Geir; Moum, Bjørn & Bernklev, Tomm (2017). Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  52(3), s 351- 358 . doi: 10.1080/00365521.2016.1256425
• Jelsness-Jørgensen, Lars-Petter; Frigstad, Svein Oskar; Moum, Bjørn; Grimstad, Tore; Opheim, Randi; Jahnsen, Jørgen & Bernklev, Tomm (2017). Pain may be an important factor to consider in inflammatory bowel disease patients troubled by fatigue. United European Gastroenterology journal.  ISSN 2050-6406.  5(5), s 687- 693 . doi: 10.1177/2050640616674654
• Kristensen, Vendel Ailin; Røseth, Arne; Ahmad, Tahir Riaz; Skar, Viggo Øystein & Moum, Bjørn (2017). Fecal Calprotectin: A Reliable Predictor of Mucosal Healing after Treatment for Active Ulcerative Colitis. Gastroenterology Research and Practice.  ISSN 1687-6121.  2017 . doi: 10.1155/2017/2098293 Fulltekst i vitenarkiv.
• Lerdal, Anners; Opheim, Randi; Gay, Caryl; Moum, Bjørn; Fagermoen, May Solveig & Kottorp, Anders (2017). Psychometric limitations of the 13-item Sense of Coherence Scale assessed by Rasch analysis. BMC Psychology.  ISSN 2050-7283.  5(18) . doi: 10.1186/s40359-017-0187-y
• Tronstad, Rune Rose; Kummen, Martin; Holm, Kristian; Volkmann, Hilde Løland Von; Anmarkrud, Jarl Andreas; Høivik, Marte Lie; Moum, Bjørn; Gilja, Odd Helge; Hausken, Trygve; Baines, John; Karlsen, Tom Hemming; Fiskerstrand, Torunn & Hov, Johannes Espolin Roksund (2017). Guanylate cyclase C activation shapes the intestinal microbiota in patients with familial diarrhea and increased susceptibility for Crohn's disease. Inflammatory Bowel Diseases.  ISSN 1078-0998.  23(10), s 1752- 1761 . doi: 10.1097/MIB.0000000000001264
• Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik; Melum, Espen; Thorbjørnsen, Liv Wenche; Paulsen, Vemund; Lundin, Knut Erik Aslaksen; Dale, Inge; Gilja, Odd Helge; Zweers, Serge J.; Vatn, Morten H; Schaap, Frank G.; Jansen, Peter L.M.; Ueland, Thor; Røsjø, Helge; Moum, Bjørn; Ponsioen, Cyriel Y.; Boberg, Kirsten Muri; Färkkilä, Martti; Karlsen, Tom Hemming & Lund-Johansen, Fridtjof (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology.  ISSN 0168-8278.  66(6), s 1214- 1222 . doi: 10.1016/j.jhep.2017.01.019
• Buer, Lydia Celine Tansem; Moum, Bjørn; Småstuen, Milada Cvancarova; Warren, David; Medhus, Asle Wilhelm & Høivik, Marte Lie (2016). Switching from Remicade® to Remsima® is well tolerated and feasible: a prospective, open-label study.. Journal - Crohn's and Colitis Foundation of Canada.  ISSN 1197-4982. . doi: 10.1093/ecco-jcc/jjw166
• Follin - Arbelet, Benoit & Moum, Bjørn (2016). Fluoride: a risk factor for inflammatory bowel disease?. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  51(9), s 1019- 1024 . doi: 10.1080/00365521.2016.1177855
• Hovde, Øistein; Høivik, Marte Lie; Henriksen, Magne; Solberg, Inger Camilla; Småstuen, Milada Cvancarova & Moum, Bjørn A (2016). Malignancies in Patients with Inflammatory Bowel Disease: Results from 20 Years of Follow-up in the IBSEN Study. Journal of Crohn's and colitis.  ISSN 1873-9946. . doi: 10.1093/ecco-jcc/jjw193
• Hovde, Øistein; Småstuen, Milada C; Høivik, Marte; Bernklev, Tomm; Huppertz-Hauss, Gert; Høie, Ole Ingebreth; Jahnsen, Jørgen; Stray, Njaal; Henriksen, Magne; Solberg, Inger Camilla & Moum, Bjørn (2016). Mortality and Causes of Death in Ulcerative Colitis: Results from 20 Years of Follow-up in the IBSEN Study. Inflammatory Bowel Diseases.  ISSN 1078-0998.  22(1), s 141- 145 . doi: 10.1097/MIB.0000000000000582
• Huppertz-Hauss, Gert; Aas, Eline; Høivik, Marte; Langholz, Ebbe; Odes, Selwyn; Småstuen, Milada C; Stockbrügger, Reinhold; Hoff, Geir; Moum, Bjørn & Bernklev, Tomm (2016). Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis. Gastroenterology Research and Practice.  ISSN 1687-6121.  2016:5023973, s 1- 9 . doi: 10.1155/2016/5023973
• Huppertz-Hauss, Gert; Høivik, Marte; Jelsness-Jørgensen, Lars-Petter; Henriksen, Magne; Høie, Ole Ingebreth; Jahnsen, Jørgen; Hoff, Geir; Moum, Bjørn & Bernklev, Tomm (2016). Health-related quality of life in patients with inflammatory bowel disease 20 years after diagnosis: results from the IBSEN study. Inflammatory Bowel Diseases.  ISSN 1078-0998.  22(7), s 1679- 1687 . doi: 10.1097/MIB.0000000000000806
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Hovde, Øistein; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Moum, Bjørn & Høivik, Marte (2016). Patients’ perceptions of quality of care and follow-up in inflammatory bowel disease. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  51(4), s 434- 441 . doi: 10.3109/00365521.2015.1102319
• Jelsness-Jørgensen, Lars-Petter; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Opheim, Randi; Berset, Ingrid Prytz; Hovde, Øistein; Torp, Roald; Frigstad, Svein Oskar; Huppertz-Hauss, Gert & Bernklev, Tomm (2016). Validity, reliability, and responsiveness of the brief pain inventory in inflammatory bowel disease. Canadian journal of gastroenterology & hepatology.  ISSN 2291-2789.  2016:5624261 . doi: 10.1155/2016/5624261
• Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika; Osnes, Liv T. N.; Holm, Kristian; Høivik, Marte; Rashidi, Azita; Dahl, Christen Peder; Vesterhus, Mette; Halvorsen, Bente; Mollnes, Tom Eirik; Berge, Rolf Kristian; Moum, Bjørn; Lundin, Knut Erik Aslaksen; Fevang, Børre; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål & Hov, Johannes Espolin Roksund (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology.  ISSN 1933-0219. . doi: 10.1038/mi.2016.18
• Kapica, Aida; Hov, Johannes Espolin Roksund; Borthne, Arne Sigmund; Gleditsch, Jostein; Johannesen, Glenn; Tveit, Knut; Viktil, Ellen; Henriksen, Magne; Hovde, Øistein; Huppertz-Hauss, Gert; Høie, Ole Ingebreth; Høivik, Marte; Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Jahnsen, Jørgen; Karlsen, Tom Hemming; Moum, Bjørn; Vatn, Morten H & Negard, Anne (2016). Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease. Gastroenterology.  ISSN 0016-5085.  151(4), s 660- 669 . doi: 10.1053/j.gastro.2016.06.021
• Kristensen, Vendel Ailin; Lauritzen, Trine; Jelsness-Jørgensen, Lars-Petter; Frigstad, Svein Oskar; Corwin, Christian & Moum, Bjørn (2016). Patient-performed extraction of faecal calprotectin. Clinical Chemistry and Laboratory Medicine.  ISSN 1434-6621.  54(8), s 1357- 1363 . doi: 10.1515/cclm-2015-1037
• Kristensen, Vendel Ailin; Malmstrøm, Gunn Helen; Skar, Viggo Øystein; Røseth, Arne & Moum, Bjørn (2016). Clinical importance of faecal calprotectin variability in inflammatory bowel disease: Intra-individual variability and standardisation of sampling procedure. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  51(5), s 548- 555 . doi: 10.3109/00365521.2015.1117650
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Nygård, Ståle; Vesterhus, Mette; Høivik, Marte; Trøseid, Marius; Marschall, Hanns-Ulrich; Schrumpf, Erik; Moum, Bjørn; Røsjø, Helge; Aukrust, Pål; Karlsen, Tom Hemming & Hov, Johannes Espolin Roksund (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut.  ISSN 0017-5749.  66(4), s 611- 619 . doi: 10.1136/gutjnl-2015-310500 Vis sammendrag

  Objective: Gut microbiota could influence gut, as well as hepatic and biliary immune responses. We therefore thoroughly characterised the gut microbiota in primary sclerosing cholangitis (PSC) compared with healthy controls (HC) and patients with ulcerative colitis without liver disease. Design: We prospectively collected 543 stool samples. After a stringent exclusion process, bacterial DNA was submitted for 16S rRNA gene sequencing. PSC and HC were randomised to an exploration panel or a validation panel, and only significant results (p<0.05, QFDR<0.20) in both panels were reported, followed by a combined comparison of all samples against UC. Results: Patients with PSC (N=85) had markedly reduced bacterial diversity compared with HC (N=263, p<0.0001), and a different global microbial composition compared with both HC (p<0.001) and UC (N=36, p<0.01). The microbiota of patients with PSC with and without IBD was similar. Twelve genera separated PSC and HC, out of which 11 were reduced in PSC. However, the Veillonella genus showed a marked increase in PSC compared with both HC (p<0.0001) and UC (p<0.02). Using receiver operating characteristic analysis, Veillonella abundance yielded an area under the curve (AUC) of 0.64 to discriminate PSC from HC, while a combination of PSC- associated genera yielded an AUC of 0.78. Conclusions: Patients with PSC exhibited a gut microbial signature distinct from both HC and UC without liver disease, but similar in PSC with and without IBD. The Veillonella genus, which is also associated with other chronic inflammatory and fibrotic conditions, was enriched in PSC.

• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tom Hemming; Berge, Rolf Kristian & Hov, Johannes Espolin Roksund (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology journal.  ISSN 2050-6406.  5(4), s 532- 541 . doi: 10.1177/2050640616663453
• Opheim, Randi; Høivik, Marte; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2016). The use of complementary and alternative medicine (CAM) among patients with inflammatory bowel disease (IBD) is associated with reduced health-related quality of life (HRQoL). Gastroenterology Research and Practice.  ISSN 1687-6121.  2016 . doi: 10.1155/2016/6453657
• Wanderås, Magnus; Moum, Bjørn; Høivik, Marte Lie & Hovde, Øistein (2016). Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies. World Journal of Gastrointestinal Pharmacology and Therapeutics (WJGPT).  ISSN 2150-5349.  7(2), s 235- 241 . doi: 10.4292/WJGPT.v7.i2.235
• Dahlerup, Jens F.; Moum, Bjørn & Lindgren, Stefan (2015). Järnbrist och järnbristanemi är globala hälsoproblem. Läkartidningen.  ISSN 0023-7205.  112 . doi: http://www.lakartidningen.se/EditorialFiles/AE/%5bDAAE%5d/DAAE.pdf
• Huppertz-Hauss, Gert; Høivik, Marte; Langholz, E; Odes, Selwyn; Småstuen, Milada Cvancarova; Stockbrügger, Reinhold; Hoff, Geir; Moum, Bjørn & Bernklev, Tomm (2015). Health-related Quality of Life in Inflammatory Bowel Disease in a European-wide Population-based Cohort 10 Years After Diagnosis. Inflammatory Bowel Diseases.  ISSN 1078-0998.  21(2), s 337- 344 . doi: 10.1097/MIB.0000000000000272
• Kristensen, Vendel Ailin; Klepp, Pasquale Catherine; Småstuen, Milada Cvancarova; Røseth, Arne; Skar, Viggo Øystein & Moum, Bjørn (2015). Prediction of endoscopic disease activity in ulcerative colitis by two different assays for faecal calprotectin. Journal of Crohn's and colitis.  ISSN 1873-9946.  9(2), s 164- 169 . doi: 10.1093/ecco-jcc/jju015
• Kristensen, Vendel Ailin; Lauritzen, Trine; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2015). Validation of a new extraction device for measuring faecal calprotectin in inflammatory bowel disease, and comparison to established extraction methods. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  75(5), s 355- 361 . doi: 10.3109/00365513.2015.1030765 Vis sammendrag

  Objective: Faecal (f-) calprotectin is a widely used surrogate marker of intestinal inflammation. F-calprotectin analysis is labour demanding partly due to a time consuming extraction step. The aim of this project was to validate a new extraction method for f-calprotectin. Material and methods: A prospective multicentre study included 135 patients with an established diagnosis of inflammatory bowel disease. The patients submitted a faeces sample, which was extracted with both the conventional method at the participating laboratory and the new extraction device. The extracts were analyzed by an automated ELISA instrument. Results: Method comparison of the traditional method and the new device showed a slope of 1.01 (0.93–1.07) with intercept of − 2.2 (− 4.9–0.6). The Spearman rank correlation coefficient was 0.96. Conclusions: The new extraction device is a reliable and time saving alternative to the conventional extraction method.

• Larsson, Geir; Bjune, Gunnar Aksel; Moum, Bjørn; Shenoy, K.T. & Småstuen, Milada Cvancarova (2015). A Risk Matrix Model for the Prediction of Intestinal Tuberculosis and Differentiation from Crohn’s Disease. Austin Journal of Gastroenterology.  ISSN 2381-9219.  2(5)
• Larsson, Geir; Shenoy, Kotacherry Thrivikrama; Ramasubramanian, Ramalingom; Thayumanavan, Lakshmikanthan; Balakumaran, Leena Kondarappassery; Bjune, Gunnar Aksel & Moum, Bjørn (2015). High faecal calprotectin levels in intestinal tuberculosis are associated with granulomas in intestinal biopsies. Infectious Diseases.  ISSN 2374-4235.  47(3), s 137- 143 . doi: 10.3109/00365548.2014.974206
• Solberg, Inger Camilla; Høivik, Marte; Småstuen, Milada C & Moum, Bjørn (2015). Risk matrix model for prediction of colectomy in a population-based study of ulcerative colitis patients (the IBSEN study). Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  50(12), s 1456- 1462 . doi: 10.3109/00365521.2015.1064991
• Vesterhus, Mette; Hov, Johannes Espolin Roksund; Holm, Anders; Schrumpf, Erik; Nygård, Ståle; Godang, Kristin; Andersen, Ina Marie; Næss, Sigrid; Thorburn, Douglas; Saffioti, Francesca; Vatn, Morten; Gilja, Odd Helge; Lund-Johansen, Fridtjof; Syversveen, Trygve; Braband, Knut; Parés, Albert; Ponsioen, Cyriel Y.; Pinzani, Massimo; Färkkilä, Martti; Moum, Bjørn; Ueland, Thor; Røsjø, Helge; Rosenberg, William; Boberg, Kirsten Muri & Karlsen, Tom Hemming (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. Hepatology.  ISSN 0270-9139.  62(1), s 188- 197 . doi: 10.1002/hep.27825
• Filmann, Natalie; Rey, Julia; Schneeweiss, Sven; Ardizzone, Sandro; Bager, Palle; Bergamaschi, Gaetano; Koutroubakis, Ioannis; Lindgren, Stefan; De La Morena, Felipe; Moum, Bjørn; Vavricka, Stephan R.; Schröder, Oliver; Herrmann, Eva & Blumenstein, Irina (2014). Prevalence of anemia in inflammatory bowel diseases in European countries: A systematic review and individual patient data meta-analysis. Inflammatory Bowel Diseases.  ISSN 1078-0998.  20(5), s 936- 945 . doi: 10.1097/01.MIB.0000442728.74340.fd
• Hovde, Øistein; Huppertz-Hauss, Gert; Høivik, Marte & Moum, Bjørn (2014). Clinical course, treatment strategies, social and economic impact of Ulcerative Colitis: An overview. Austin Journal of Gastroenterology.  ISSN 2381-9219.  1(4), s 1- 9 . doi: id1017
• Hovde, Øistein; Kempski-Monstad, Iril Lovise; Småstuen, Milada Cvancarova; Solberg, Inger Camilla; Henriksen, Magne; Jahnsen, Jørgen; Stray, Njaal & Moum, Bjørn (2014). Mortality and causes of death in Crohn's disease: Results from 20 years of follow-up in the IBSEN study. Gut.  ISSN 0017-5749.  63(5), s 771- 775 . doi: 10.1136/gutjnl-2013-304766
• Høivik, Marte; Reinisch, Walter; Småstuen, Milada Cvancarova & Moum, Bjørn (2014). Anaemia in inflammatory bowel disease: a population-based 10-year follow-up. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  39(1), s 69- 76 . doi: 10.1111/apt.12541
• Isene, Rune; Bernklev, Tomm; Høie, Ole Ingebreth; Langholz, Ebbe; Tsianos, Epameinondas V.; Stockbrügger, Reinhold; Odes, Selwyn; Småstuen, Milada Cvancarova & Moum, Bjørn (2014). Thromboembolism in inflammatory bowel disease: results from a prospective, population-based European inception cohort. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  49(7), s 820- 825 . doi: 10.3109/00365521.2014.910545
• Isene, Rune; Bernklev, Tomm; Høie, Ole Ingebreth; Munkholm, Pia; Tsianos, Epameinondas V.; Stockbrügger, Reinhold; Odes, Selwyn; Palm, Øyvind; Småstuen, Milada Cvancarova & Moum, Bjørn (2014). Extraintestinal manifestations in Crohn’s disease and ulcerative colitis: results from a prospective, population based European inception cohort. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  50(3), s 300- 305 . doi: 10.3109/00365521.2014.991752
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm & Moum, Bjørn (2014). Coexisting irritable bowel-like symptoms in inflammatory bowel disease in remission is associated with impaired social functioning and increased bodily pain. Gastroenterology Nursing.  ISSN 1042-895X.  37(4), s 280- 287 . doi: 10.1097/SGA.0000000000000055
• Kempski-Monstad, Iril Lovise; Hovde, Øistein; Solberg, Inger Camilla & Moum, Bjørn (2014). Clinical course and prognosis in ulcerative colitis: Results from population-based and observational studies. Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology..  ISSN 1108-7471.  27(2), s 95- 104 Vis sammendrag

  The clinical course of ulcerative colitis (UC) may range from a quiescent course with prolonged periods of remission to fulminant disease requiring intensive medical treatment or surgery. Disease outcome is often determined by relapse rates, the development of colorectal cancer (CRC) and mortality rates. Early patient classification, identifying those with a high risk of developing complicated disease, is essential for choosing appropriate treatment. This paper reviews the clinical outcomes of UC patients as reported in population-based and observational studies representative of the whole patient population. Extensive colitis, a high level of systemic symptoms and young age at diagnosis are factors associated with a high risk of colectomy. Patients with distal disease who progress to extensive colitis seem to be a subgroup with an especially high risk of colectomy. Some prognostic factors of severe disease have been identified which could be used to optimize treatment and possibly reduce future complications. The overall risk of CRC and mortality was not significantly different from that of the background population. These results may have implications for follow-up strategies, especially regarding endoscopic surveillance of UC patients.

• Larsson, Geir; Koticherry Thrivikrama, Shenoy; Ramasubramanian, Ramalingom; Lakshmikanthan, Thayumanavan; Leena Kondarappassery, Balakumaran; Bjune, Gunnar Aksel & Moum, Bjørn (2014). Faecal calprotectin levels differentiate intestinal from pulmonary tuberculosis: An observational study from Southern India. United European Gastroenterology journal.  ISSN 2050-6406. . doi: 10.1177/2050640614546947
• Larsson, Geir; Shenoy, Thrivikrama; Ramasubramanian, Ramalingom; Balakumaran, Leena Kondarappassery; Småstuen, Milada Cvancarova; Bjune, Gunnar Aksel & Moum, Bjørn (2014). Routine diagnosis of intestinal tuberculosis and Crohn´s disease in Southern India. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  20(17), s 5017- 5024 . doi: 10.3748/wjg.v20.i17.5017
• Moum, Bjørn; Hovde, Øistein & Høivik, Marte (2014). What have we learnt about the role of the environment and natural course of IBD in the new millennium? 20-year follow-up of the IBSEN cohort. Digestive Diseases.  ISSN 0257-2753.  32, s 2- 9 . doi: 10.1159/000367818 Vis sammendrag

  The incidence and prevalence of IBD, both Crohn's disease (CD) and ulcerative colitis (UC), have increased in recent years, especially in industrialized countries. Still, the etiology of IBD remains largely unknown. Most research on IBD before the 1990s was conducted on selected patient populations. Selected patient populations are likely to introduce important bias and limit the interpretation and generalizability. The inclusion of both incident and prevalent cases or the inclusion of incident cases over long periods of time (decades) might also introduce bias due to changes in treatment regimens and socioeconomic factors over timer (time-trend bias). Consequently, the choice of a well-characterized population-based inception cohort provides the best opportunity to describe the natural course of a disease. The IBSEN (Inflammatory Bowel Disease in South-Eastern Norway) study followed a large population-based cohort of newly diagnosed IBD patients for 20 years and has contributed significantly to the knowledge of the natural course of IBD.

• Opheim, Randi; Fagermoen, May Solveig; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2014). Fatigue interference with daily living among patients with inflammatory bowel disease. Quality of Life Research.  ISSN 0962-9343.  23(2), s 709- 719 . doi: 10.1007/s11136-013-0508-4
• Opheim, Randi; Fagermoen, May Solveig; Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm & Moum, Bjørn (2014). Sense of coherence in patients with inflammatory bowel disease. Gastroenterology Research and Practice.  ISSN 1687-6121.  2014:989038 . doi: 10.1155/2014/989038
• Solberg, Inger Camilla; Småstuen, Milada Cvancarova; Vatn, Morten H; Moum, Bjørn; Lygren, Idar; Jahnsen, Jørgen; Høie, Ole; Henriksen, Magne; Stray, Njål; Røseth, Arne & Sauar, Jostein (2014). Risk matrix for prediction of advanced disease in a population-based study of patients with Crohn's Disease (the IBSEN Study). Inflammatory Bowel Diseases.  ISSN 1078-0998.  20(1), s 60- 68 . doi: 10.1097/01.MIB.0000436956.78220.67
• Bager, Palle; Befrits, Ragnar; Wikman, Ola; Lindgren, Stefan; Moum, Bjørn; Hjortswang, Henrik & Dahlerup, Jens F. (2013). High burden of iron deficiency and different types of anemia in inflammatory bowel disease outpatients in Scandinavia: A longitudinal 2-year follow-up study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  48(11), s 1286- 1293 . doi: 10.3109/00365521.2013.838605
• Bernstein, Charles N.; Ng, Siew C.; Lakatos, Peter Laszlo; Moum, Bjørn & Loftus, Edward V. (2013). A review of mortality and surgery in ulcerative colitis: milestones of the seriousness of the disease. Inflammatory Bowel Diseases.  ISSN 1078-0998.  19(9), s 2001- 2010 . doi: 10.1097/MIB.0b013e318281f3bb
• Høivik, Marte; Moum, Bjørn; Solberg, Inger Camilla; Henriksen, Magne; Småstuen, Milada C & Bernklev, Tomm (2013). Work disability in inflammatory bowel disease patiens 10 years after disease onset: results from the IBSEN Study. Gut.  ISSN 0017-5749.  62(3), s 368- 375 . doi: 10.1136/gutjnl-2012-302311
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm & Moum, Bjørn (2013). Calprotectin Is a Useful Tool in Distinguishing Coexisting Irritable Bowel-Like Symptoms from That of Occult Inflammation among Inflammatory Bowel Disease Patients in Remission. Gastroenterology Research and Practice.  ISSN 1687-6121. . doi: 10.1155/2013/620707
• Ng, Siew C.; Bernstein, Charles N.; Vatn, Morten H; Lakatos, Peter Laszlo; Loftus Jr, Edward V.; Tysk, Curt; O'Morain, Colm; Moum, Bjørn & Colombel, Jean-Frédéric (2013). Geographical variability and environmental risk factors in inflammatory bowel disease. Gut.  ISSN 0017-5749.  62(4), s 630- 649 . doi: 10.1136/gutjnl-2012-303661
• Reinisch, Walter; Chowers, Yehuda; Danese, Silvio; Dignass, Axel; Gomollon, Fernando; Haagen Nielsen, Ole; Lakatos, Peter Laszlo; Lees, Charlie W.; Lindgren, Stefan; Lukás, Milan; Mantzaris, Gerassimos J.; Michetti, Pierre; Moum, Bjørn; Peyrin-Biroulet, Laurent; Toruner, Murat; van der Woude, Janneke; Weiss, Günter & Stoevelaar, Herman (2013). The management of iron deficiency in inflammatory bowel disease - an online tool developed by the RAND/UCLA appropriateness method. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  38(9), s 1109- 1118 . doi: 10.1111/apt.12493
• Bager, P.; Befrits, R; Wikman, O; Lindgren, S.; Moum, Bjørn; Hjortswang, H.; Hjollund, N.H. & Dahlerup, Jens F. (2012). Fatigue in out-patients with inflammatory bowel disease is common and multifactorial. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  35(1), s 133- 141 . doi: 10.1111/j.1365-2036.2011.04914.x
• Bernstein, Charles N.; Loftus, Edward V.; Ng, Siew C.; Lakatos, Peter Laszlo & Moum, Bjørn (2012). Hospitalisations and surgery in Crohn's disease. Gut.  ISSN 0017-5749.  61(4), s 622- 629 . doi: 10.1136/gutjnl-2011-301397
• Hovde, Øistein & Moum, Bjørn (2012). Epidemiology and clinical course of Crohn's disease: Results from observational studies. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  18(15), s 1723- 1731 . doi: 10.3748/wjg.v18.i15.1723
• Høivik, Marte; Bernklev, Tomm; Solberg, Inger Camilla; Småstuen, Milada C; Lygren, Idar; Jahnsen, Jørgen & Moum, Bjørn (2012). Patients with Crohn's disease experience reduced general health and vitality in the chronic stage: Ten-year results from the IBSEN study. Journal - Crohn's and Colitis Foundation of Canada.  ISSN 1197-4982.  6(4), s 441- 453 . doi: 10.1016/j.crohns.2011.10.001
• Høivik, Marte; Moum, Bjørn; Solberg, Inger Camilla; Småstuen, Milada C; Høie, Ole Ingebreth; Vatn, Morten H & Bernklev, Tomm (2012). Health-related quality of life in patients with ulcerative colitis after a 10-year disease course: results from the IBSEN study. Inflammatory Bowel Diseases.  ISSN 1078-0998.  18(8), s 1540- 1549 . doi: 10.1002/ibd.21863
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Henriksen, Magne; Torp, Roald & Moum, Bjørn (2012). Chronic fatigue is associated with increased disease-related worries and concerns in inflammatory bowel disease. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  18(5), s 445- 452 . doi: 10.3748/wjg.v18.i5.445
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Henriksen, Magne; Torp, Roald & Moum, Bjørn (2012). Is patient reported outcome (PRO) affected by different follow-up regimens in inflammatory bowel disease(IBD)? A one year prospective, longitudinal comparison of nurse-led versus conventional follow-up. Journal - Crohn's and Colitis Foundation of Canada.  ISSN 1197-4982.  6(9), s 887- 894 . doi: 10.1016/j.crohns.2012.01.021
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm & Moum, Bjørn (2012). Fatigue and disease-related worries among inflammatory bowel disease patients in remission; is it a reflection of coexisting IBS-like symptoms? A short report. Journal of Psychosomatic Research.  ISSN 0022-3999.  73(6), s 469- 472 . doi: 10.1016/j.jpsychores.2012.08.009
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm & Moum, Bjørn (2012). Quality of life in patients with inflammatory bowel disease: translation, validity, reliability and sensitivity to change of the Norwegian version of the Short Health Scale (SHS). Quality of Life Research.  ISSN 0962-9343.  21(9), s 1671- 1676 . doi: 10.1007/s11136-011-0081-7
• Jonasson, Christian; Moum, Bjørn; Bang, Christen Joachim; Andersen, knut Robert & Hatlebakk, Jan Gunnar (2012). Randomised clinical trial: a comparison between a GerdQ‐based algorithm and an endoscopy‐based approach for the diagnosis and initial treatment of GERD. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813. . doi: 10.1111/j.1365-2036.2012.05092.x
• Jonasson, Christian; Moum, Bjørn; Bang, Christen; Andersen, knut Robert & Hatlebakk, Jan G (2012). Randomised clinical trial: a comparison between a GerdQ-based algorithm and an endoscopy-based approach for the diagnosis and initial treatment of GERD. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  35(11), s 1290- 1300 . doi: 10.1111/j.1365-2036.2012.05092.x
• Opheim, Randi; Bernklev, Tomm; Fagermoen, May Solveig; Småstuen, Milada C & Moum, Bjørn (2012). Use of complementary and alternative medicine in patients with inflammatory bowel disease: results of a cross-sectional study in Norway. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  47(12), s 1436- 1447 . doi: 10.3109/00365521.2012.725092
• Opheim, Randi; Høivik, Marte; Solberg, Inger Camilla & Moum, Bjørn (2012). Complementary and alternative medicine in patients with inflammatory bowel disease: The results of a population-based inception cohort study (IBSEN). Journal - Crohn's and Colitis Foundation of Canada.  ISSN 1197-4982.  6(3), s 345- 353 . doi: 10.1016/j.crohns.2011.09.007
• Bager, Palle; Befrits, Ragnar; Wikman, Ola; Lindgren, Stefan; Moum, Bjørn; Hjortswang, Henrik & Dahlerup, Jens F. (2011). The prevalence of anemia and iron deficiency in IBD outpatients in Scandinavia. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  46(3), s 304- 309 . doi: 10.3109/00365521.2010.533382
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Henriksen, Magne; Torp, Roald & Moum, Bjørn (2011). Chronic Fatigue Is More Prevalent in Patients with Inflammatory Bowel Disease than in Healthy Controls. Inflammatory Bowel Diseases.  ISSN 1078-0998.  17(7), s 1564- 1572 . doi: 10.1002/ibd.21530
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Henriksen, Magne; Torp, Roald & Moum, Bjørn (2011). Chronic fatigue is associated with impaired health-related quality of life in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  33(1), s 106- 114 . doi: 10.1111/j.1365-2036.2010.04498.x
• Jelsness-Jørgensen, Lars-Petter; Moum, Bjørn & Bernklev, Tomm (2011). Worries and Concerns among Inflammatory Bowel Disease Patients Followed Prospectively over One Year. Gastroenterology Research and Practice.  ISSN 1687-6121. . doi: 10.1155/2011/492034
• Jelsness-Jørgensen, Lars-Petter; Ribu, Lis; Bernklev, Tomm & Moum, Bjørn (2011). Measuring health-related quality of life in non-complicated diabetes patients may be an effective parameter to assess patients at risk of a more serious disease course: a cross-sectional study of two diabetes outpatient groups. Journal of Clinical Nursing (JCN).  ISSN 0962-1067.  20(9-10), s 1255- 1263 . doi: 10.1111/j.1365-2702.2010.03554.x
• Katsanos, Konstantinos H.; Tatsioni, Athina; Pedersen, Natalia; Shuhaibar, Mary; Ramirez, Vincent Hernandez; Politi, Patrizia; Rombrechts, Eevelien; Pierik, Marieke; Clofent, Juan; Beltrami, Marina; Bodini, Paolo; Freitas, Joao; Mouzas, Ioannis; Fornaciari, Giovanni; Moum, Bjørn; Lakatos, Peter Laszlo; Vermeire, Severine; Langholz, Ebbe; Odes, Selwyn; Morain, Colm O.; Stockbrügger, Reinhold; Munkholm, Pia & Tsianos, Epameinondas V. (2011). Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study. Journal - Crohn's and Colitis Foundation of Canada.  ISSN 1197-4982.  5(5), s 430- 442 . doi: 10.1016/j.crohns.2011.04.013
• Bengtson, May-Bente; Solberg, Inger Camilla; Aamodt, Geir; Jahnsen, Jørgen; Moum, Bjørn & Vatn, Morten H (2010). Relationships between inflammatory bowel disease and perinatal factors: Both maternal and paternal disease are related to preterm birth of offspring. Inflammatory Bowel Diseases.  ISSN 1078-0998.  16(5), s 847- 855 . doi: 10.1002/ibd.21120
• Høivik, Marte; Bernklev, Tomm & Moum, Bjørn (2010). Need for Standardization in Population-Based Quality of Life Studies: A Review of the Current Literature. Inflammatory Bowel Diseases.  ISSN 1078-0998.  16(3), s 525- 536 . doi: 10.1002/ibd.21032
• Odes, S; Vardi, H; Friger, M; Esser, D; Wolters, F; Moum, Bjørn; Waters, H; Elkjaer, M; Bernklev, Tomm; Tsianos, E; O'Morain, C; Stockbrugger, R; Munkholm, P & Langholz, E (2010). Clinical and economic outcomes in a population-based European cohort of 948 ulcerative colitis and Crohn's disease patients by Markov analysis. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  31(7), s 735- 744 . doi: 10.1111/j.1365-2036.2009.04228.x
• Solberg, Camilla; Lygren, Idar; Jahnsen, Jørgen; Aadland, Erling; Høie, Ole; Cvancarova, Milada; Bernklev, Tomm; Henriksen, Magne; Sauar, Jostein; Vatn, Morten H & Moum, Bjørn (2009). Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study). Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  44(4), s 431- 440 . doi: 10.1080/00365520802600961
• Solberg, Inger Camilla; Lygren, Idar; Cvancarova, Milada; Jahnsen, Jørgen; Stray, N.; Sauar, J.; Schreiber, S; Moum, Bjørn & Vatn, Morten H (2009). Predictive Value of Serologic Markers in a Population-based Norwegian Cohort with Inflammatory Bowel Disease. Inflammatory Bowel Diseases.  ISSN 1078-0998.  15(3), s 406- 414 . doi: 10.1002/ibd.20781
• Bengtson, May-Bente; Solberg, Inger Camilla; Aamodt, Geir; Jahnsen, Jørgen; Moum, Bjørn; Sauar, Jostein & Vatn, Morten H (2009). Clustering in time of familial IBD separates ulcerative colitis from Crohn's disease. Inflammatory Bowel Diseases.  ISSN 1078-0998.  15(12), s 1867- 1874 . doi: 10.1002/ibd.20978
• Solberg, Inger Camilla; Lygren, Idar; Cvancarova, Milada; Jahnsen, Jørgen; Stray, Njaal; Sauar, Jostein; Schreiber, Stefan; Moum, Bjørn & Vatn, Morten H (2008). Predictive value of serologic markers in a population-based norwegian cohort with inflammatory bowel disease. Inflammatory Bowel Diseases.  ISSN 1078-0998. . doi: 10.1002/ibd.20781
• Aamodt, Geir; Bukholm, Geir; Jahnsen, Jørgen; Moum, Bjørn & Vatn, Morten H (2008). The association between water supply and inflammatory bowel disease based on a 1990-1993 cohort study in southeastern Norway. American Journal of Epidemiology.  ISSN 0002-9262.  168(9), s 1065- 1072 . doi: 10.1093/aje/kwn218
• Henriksen, M; Jahnsen, J; Lygren, I; Stray, N; Sauar, J; Vatn, Morten H & Moum, Bjørn (2008). C-reactive protein: a predictive factor and marker of innflammation in inflammatory bowel disease. Results from a prospective population-based study. Gut.  ISSN 0017-5749.  57(11), s 1518- 23 . doi: 10.1136/gut.2007.146357
• Henriksen, M; Jahnsen, J; Lygren, I; Aadland, E; Schulz, T; Vatn, Morten H & Moum, Bjørn (2007). Clinical course in Crohn's disease: Results of a five-year population-based follow-up study (the IBSEN study). Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  42 . doi: 10.1080/00365520601076124
• Henriksen, M; Jahnsen, J; Lygren, I; Vatn, Morten H & Moum, Bjørn (2007). Are there any differences in phenotype or disease course between familial and sporadic cases of inflammatory bowel disease? Results of a population-based follow-up study. American Journal of Gastroenterology.  ISSN 0002-9270.  102, s 1955- 1963 . doi: 10.1111/j.1572-0241.2007.01368.x
• Hoie, O; Schouten, L J; Wolters, F.L; Solberg, Inger Camilla; Riis, L; Mouzas, I.A; Politi, P; Odes, S; Langholz, E; Vatn, Morten H; Stockbrügger, R W & Moum, Bjørn (2007). Ulcerative colitis: no rise in mortality in a European-wide population based cohort 10 years after diagnosis. Gut.  ISSN 0017-5749.  56(4), s 497- 503 . doi: 10.1136/gut.2006.101519
• Hoie, O; Wolters, F; Riis, L; Aamodt, Geir; Solberg, Camilla; Bernklev, T; Odes, S; Mouzas, IA; Beltrami, M; Langholz, E; Stockbrugger, R; Vatn, Morten H & Moum, Bjørn (2007). Ulcerative colitis: Patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort. American Journal of Gastroenterology.  ISSN 0002-9270.  102, s 1692- 1701 . doi: 10.1111/j.1572-0241.2007.01265.x
• Bernklev, Tomm; Jahnsen, Jørgen; Henriksen, Magne; Lygren, Idar; Aadland, Erling; Sauar, Jostein; Schulz, Tom; Stray, Njål; Vatn, Morten H & Moum, Bjørn (2006). Relationship between sick leave, unemployment, disability, and health-related quality of life in patients with inflammatory bowel disease. Inflammatory Bowel Diseases.  ISSN 1078-0998.  12(5), s 402- 412
• Henriksen, Magne; Jahnsen, Jørgen; Sauar, Jostein; Lygren, Idar; Schulz, Tom; Stray, Njål; Vatn, Morten H & Moum, Bjørn (2006). Change of diagnosis during the first five years after onset of inflammatory bowel disease: Results of a prospective follow-up study (the IBSEN Study). Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  41, s 1037- 1043
• Høie, O; Schouten, LJ; Wolters, FL; Solberg, IC; Riis, L; Mouzas, IA; Politi, P; Odes, S; Langholz, E; Vatn, Morten H; Stockbrügger, RW & Moum, Bjørn (2006). Ulcerative colitis: No rise in mortality in a european-wide population-based cohort 10 years after diagnosis. Gut.  ISSN 0017-5749. . doi: 10.1136/gut.2006.101519
• Tangen, M; Andersen, SJ; Moum, Bjørn & Hauge, Truls (2006). Stent insertion as palliation of cancer in the esophagus and cardia. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  126(12), s 1607- 1609
• Moum, Bjørn; Hauge, Truls; Lerang, F.; Sandvei, P.; Henriksen, M & Pettersen, T (2001). Assessment of the need of 24-hour availability of endoscopy. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  121(29), s 3396- 3398
• Hauge, Truls; Moum, Bjørn; Sandvei, P.; Lerang, F. & Ravneng, P (2000). Argon plasma coagulation--a new method in therapeutic endoscopy. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  120(12), s 1413- 1415
• Lerang, F.; Moum, Bjørn; Ragnhildstveit, E; Haug, JB; Hauge, Truls; Tolås, P; Aubert, E; Henriksen, M; Efskind, PS; Nicolaysen, K; Søberg, T; Odegaard, A & Berge, T (1997). A comparison between omeprazole-based triple therapy and bismuth-based triple therapy for the treatment of Helicobacter pylori infection: a prospective randomized 1-yr follow-up study. American Journal of Gastroenterology.  ISSN 0002-9270.  92(4), s 653- 658

Se alle arbeider i Cristin

• Mortensen, Joachim Høg; Lunder, Aida Kapic; Manon-Jensen, Tina; Karsdal, MA; Nielsen, Mette; Leeming, DJ; Hov, Johannes Espolin Roksund; Negård, Anne; Jahnsen, Jørgen; Moum, Bjørn; Vesterhus, Mette; Høivik, Marte Lie & Kristensen, Vendel Ailin (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study.
• Opheim, Randi; Jahnsen, Jørgen; Bernklev, Tomm; Høie, Ole Ingebreth; Huppertz-Hauss, Gert & Moum, Bjørn (2019). Complementary and alternative medicine in patients with inflammatory bowel disease 20 years after diagnosis: Results from the IBSEN study. American Journal of Gastroenterology.  ISSN 0002-9270.  114, s S12- S13 . doi: 10.14309/01.ajg.0000578256.56976.23
• Kristensen, Vendel Ailin; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Moum, Bjørn & Vatn, Morten (2018). Long term stability of serological antibodies in a population-based inception cohort of inflammatory bowel disease - The IBSEN study.
• Frigstad, Svein Oskar; Bernklev, Tomm; Dahl, Sandra Rinne; Hovde, Øistein; Jahnsen, Jørgen; Grimstad, Tore; Berset, Ingrid Prytz; Moum, Bjørn; Huppertz-Hauss, Gert & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency is not associated with chronic fatigue in inflammatory bowel disease.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Dahl, Sandra Rinne; Cvancarova, Milada; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency is not associated with depression in IBD patients. Journal of Crohn's and colitis.  ISSN 1873-9946.  11, s 444- 445 . doi: 10.1093/ecco-jcc/jjx002.834
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada C; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Fatigue is not Associated with Vitamin D Deficiency in IBD Patients. Gastroenterology.  ISSN 0016-5085.  152(5), s S945 . doi: 10.1016/S0016-5085(17)33218-3
• Frigstad, Svein Oskar; Høivik, Marte Lie; Moum, Bjørn; Dahl, Sandra Rinne; Jahnsen, Jørgen; Småstuen, Milada Cvancarova; Grimstad, Tore; Berset, Ingrid Prytz; Torp, Roald; Hovde, Øistein; Bernklev, Tomm & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency is not associated with depression in IBD patients.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Småstuen, Milada C; Jahnsen, Jørgen; Dahl, Sandra Rinne; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Grimstad, Tore; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Fatigue er ikke assosiert med vitamin D mangel hos IBD pasienter.
• Henriksen, Magne; Jelsness-Jørgensen, Lars-Petter; Høivik, Marte Lie & Moum, Bjørn (2017). Symptomer på irritabel tarmsyndrom (IBS)forekommer hyppig ved ulcerøs kolitt (UC) uavhengig av hvordan remisjon defineres. Resultater fra 20 års oppfølging i IBSEN studien.
• Bernklev, Tomm; Huppertz-Hauss, Gert; Opheim, Randi; Høivik, Marte; Moum, Bjørn; Jelsness-Jørgensen, Lars-Petter & Henriksen, Magne (2016). Co-existing Irritable Bowel Syndrome (IBS) in Inflammatory Bowel Disease (IBD) is associated with increased risk of chronic fatigue (CF), especially in females.
• Kristensen, Vendel Ailin; Røseth, Arne; Ahmad, Tahir; Skar, Viggo Øystein & Moum, Bjørn (2016). Faecal calprotectin is a useful marker of mucosal healing after treatment for active ulcerative colitis.
• Jelsness-Jørgensen, Lars-Petter; Lie Høivik, Marte; Moum, Bjørn; Opheim, Randi; Huppertz-Hauss, Gert; Grimstad, Tore; Berset, Ingrid Prytz; Frigstad, Svein Oskar; Hovde, Øistein & Bernklev, Tomm (2015). Fatigue is associated with increased pain intensity and interference in IBD. Inflammatory Bowel Diseases.  ISSN 1078-0998. . doi: 10.1080/00365521
• Kristensen, Vendel Ailin; Malmstrøm, Gunn; Skar, Viggo Øystein & Moum, Bjørn (2015). Clinical relevance of faecal calprotectin variability in inflammatory bowel disease.
• Kristensen, Vendel Ailin; Malmstrøm, Gunn; Skar, Viggo Øystein & Moum, Bjørn (2015). Clinical relevance of faecal calprotectin variability in inflammatory bowel disease.
• Kristensen, Vendel Ailin & Moum, Bjørn (2015). Correspondence: Fecal calprotectin and cut-off levels in inflammatory bowel disease. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  50(9), s 1183- 1184 . doi: 10.3109/00365521.2015.1025830
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Vesterhus, Mette; Høivik, Marte; Trøseid, Marius; Marschall, Hanns-Ulrich; Schrumpf, Erik; Moum, Bjørn; Aukrust, Pål; Karlsen, Tom Hemming & Hov, Johannes Espolin Roksund (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tom Hemming; Berge, Rolf Kristian & Hov, Johannes Espolin Roksund (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS.
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tor Hemming; Berge, Rolf Kristian & Hov, Johannes Espolin Roksund (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.. Vis sammendrag

  Background and Aims: Trimethylamine-N-oxide (TMAO) is produced in the liver from trimethylamine, which is exclusively generated by gut bacteria from dietary choline and carnitine found in e.g. red meat and dairy products. TMAO influences bile acid levels, metabolism and potentially also inflammation. Given the production in the liver, link to the gut microbiota and bile acid homeostasis, we aimed to investigate the regulation of TMAO in primary sclerosing cholangitis (PSC). Methods: We measured serum TMAO in 305 PSC patients, 90 ulcerative colitis (UC) patients and 99 healthy controls (HC), with a median age (male %) of 41 (76), 38 (51) and 40 (60), respectively. Reduced liver function was defined by increased prothrombin time (International Normalized Ratio >1.2 or Normotest <70). Results: TMAO level was lower in PSC patients than in UC and HC (medians 3.1, 4.0 and 3.5, respectively, p < 0.05 versus HC and UC). We hypothesized that this could be explained by reduced liver function affecting TMAO production. In line with this, TMAO in PSC with reduced liver function, but not TMAO in those with normal liver function, was lower than in HC (p < 0.05). The TMAO level in UC was higher than in PSC irrespective of liver function (p < 0.05), while TMAO was similar in PSC patients with and without inflammatory bowel disease. Focusing on PSC patients with normal liver function, the TMAO level was higher in patients reaching an end-point during follow-up (liver transplantation, n = 70, or all-cause death, n = 21) than those without (median 4.6 versus 2.7, p = 0.001). AUROC-analysis yielded an AUC of 0.64 (p < 0.001) with a suggested optimal TMAO cut-off of 4.1mM. When stratified by this value, PSC patients with high TMAO exhibited shorter transplantation-free survival than patients with low TMAO (median 3.0 versus 16.2 years, p < 0.001, Figure 1). In Cox regressions, TMAO>4.1mM and Mayo risk score were independently associated with transplantation-free survival, with HR 2.0 (95% CI 1.2–3.1, p = 0.005) and 1.5 (95% CI 1.2–1.8, p < 0.001), respectively. Conclusions: PSC patients with impaired liver function had decreased TMAO level, suggesting that TMAO may be influenced by reduced liver function. On the other hand, in PSC patients with normal liver function, elevated TMAO was associated with a shorter liver transplantation-free survival, suggesting that dietary factors and gut microbiota profile may be relevant for the disease prognosis in PSC.

• Opheim, Randi; Høivik Lie, Marte; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2015). Relationship between use of complementary and alternative medicine (CAM) and health-related quality of life (HRQoL) among patients with inflammatory bowel disease.. Journal of Crohn’s and Coltis Supplements.  ISSN 1873-9954.  9
• Bernklev, Tomm; Huppertz-Hauss, Gert; Jelsness-Jørgensen, Lars-Petter; Høivik, Marte; Opheim, Randi; Jahnsen, Jørgen & Moum, Bjørn (2014). Chronic Fatigue Twenty Years After Diagnosis. Results from the IBSEN-Study. Inflammatory Bowel Diseases.  ISSN 1078-0998.  20(12), s 31- 32 . doi: 10.1097/01.MIB.0000456782.03905.38
• Gomóllon, Fernando; Chowers, Yehuda; Danese, Silvio; Dignass, Axel U.; Haagen Nielsen, Ole; Lakatos, Péter László; Lees, Charlie W.; Lindgren, Stefan C.; Lukáš, Milan; Mantzaris, Gerassimos J.; Michetti, Pierre F.; Moum, Bjørn; Peyrin-Biroulet, Laurent; Törüner, Milan; van der Woude, Janneke; Weiss, Günter; Stoevelaar, Herman J. & Reinisch, Walter W. (2014). Letter: European Medicines Agency recommendations for allergic reactions to intravenous iron-containing medicines. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  39(7), s 743- 744 . doi: 10.1111/apt.12648
• Lundin, Knut Erik Aslaksen & Moum, Bjørn (2014). Biotilsvarende legemidler ved inflammatorisk tarmsykdom. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  8(134), s 819- 8120 . doi: 10.4045/tidsskr.14.0192
• Hovde, Øistein & Moum, Bjørn (2013). Langtidsoppfølging av pasienter med Crohns sykdom - IBSEN-studien finner bedre progose enn tidligere antatt. BestPractice.  9, s 7- 9
• Borg, S.; Gerdtham, Ulf-G.; Ryden, T.; Munkholm, P; Odes, S; Langholz, E; Moum, Bjørn; Annese, V; Bagnoli, S.; Beltrami, M; Clofent, J; Friger, M; Milla, Monica; Mouzas, I; O'Morain, C; Politi, P; Riis, L; Stockbrugger, R; Tsianos, E; Vardi, H & Lindgren, S. (2012). ESTIMATION OF A MARKOV CHAIN FOR CROHN'S DISEASE AND CLASSIFICATION OF PATIENTS INTO DISEASE PHENOTYPES, IN EIGHT COUNTRIES USING INDIVIDUAL LONGITUDINAL DATA AGGREGATED OVER TIME. Value in Health.  ISSN 1098-3015.  15(7), s A466- A467
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Henriksen, Magne; Torp, Roald & Moum, Bjørn (2012). Is patient reported outcome (PRO) affected by different follow-up regimens in inflammatory bowel disease (IBD)?.
• Larsson, Geir; Shenoy, K.; Røseth, Arne; Bjune, Gunnar Aksel & Moum, Bjørn (2011). Diagnosis and differentiation of intestinal tuberculosis and Crohn's disease by use of faecal and serum calprotectin. Inflammatory Bowel Diseases.  ISSN 1078-0998.  17, s S35- S35
• Antonsen, Anniken; Opheim, Randi; Schnierer, Martin; Bernklev, Tomm; Hyrdel, Rudolf & Moum, Bjørn (2010). Use of complementary and alternative medicine in Inflammatory bowel disease. Results from a hospital based registry in Slovakia. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  45, s 51- 51
• Bager, Palle; Befrits, Ragnar; Wikman, Ola; Lindgren, Stefan; Moum, Bjørn; Hjortswang, Henrik & Dahlerup, Jens F. (2010). The "true" prevalence of anemia in IBD outpatients in Scandinavia. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  45, s 55- 56
• Hatlebakk, Jan G; Lerang, Frode & Moum, Bjørn (2010). Protonpumpehemmere gir ikke magekreft. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  130(6), s 592 . doi: 10.4045/tidsskr.10.0084
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Henriksen, Magne; Torp, Reidun & Moum, Bjørn (2010). Chronic fatigue (CF) is 2-3 times more common in Norwegian IBD patients than the normal population (NP) and it significantly decreases the patients health-related quality of life (HRQOL). Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  45, s 50- 51
• Larsson, Geir; Shenoy, K.T.; Røseth, Arne; Bjune, Gunnar Aksel & Moum, Bjørn (2010). Evaluation of faecal and serum calprotectin in patients with intestinal tuberculosis. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  45, s 72- 72
• Moum, Bjørn (2010). Do Gastroenterologists solve or create the problems for surgeons in severe UC? Solve. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  45(supp. 247), s 36- 37
• Moum, Bjørn & Jahnsen, Jørgen (2010). Fedmekirurgi ved inflammatorisk tarmsykdom. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  130(6), s 638- 639
• Moum, Bjørn; Jahnsen, Jørgen & Bernklev, Tomm (2010). Fecal Calprotectin Variability in Crohn's Disease. Inflammatory Bowel Diseases.  ISSN 1078-0998.  16(7), s 1091- 1092 . doi: 10.1002/ibd.21136
• Solberg, Inger Camilla; Småstuen, Milada C; Vatn, Morten H & Moum, Bjørn (2010). Risk matrix model for prediction of 5-year outcome of disease in a population based study of Crohn's disease patients.The IBSEN Study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  45, s 71- 71
• Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter; Henriksen, Magne; Torp, Roald & Moum, Bjørn (2009). FATIGUE IN NORWEGIAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE COMPARED TO FATIGUE IN THE BACKGROUND POPULATION. Gut.  ISSN 0017-5749.
• Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter; Henriksen, Magne; Torp, Roald & Moum, Bjørn (2009). THE IMPORTANCE OF CHRONIC FATIGUE ON HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Gut.  ISSN 0017-5749.
• Torp, Roald; Jelsness-Jørgensen, Lars-Petter; Henriksen, Magne; Bernklev, Tomm & Moum, Bjørn (2009). FECAL CALPROTECTINE MAY DIFFERNSIATE BETWEEN IBS AND IBD SYMPTOMS IN IBD PATIENTS. Scandinavian Journal of Gastroenterology, Supplement.  ISSN 0085-5928.  44
• Torp, Roald; Jelsness-Jørgensen, Lars-Petter; Henriksen, Magne; Bernklev, Tomm & Moum, Bjørn (2009). FOREKOMST AV IBS-SYMPTOMER HOS IBD PASIENTER.
• Aamodt, Geir; Jahnsen, Jørgen; Moum, Bjørn & Vatn, Morten H (2008). Water supply and Inflammatory Bowel Disease based on a Norwegian cohort study from 1990-93 in South Eastern Norway.
• Aamodt, Geir; Jahnsen, Jørgen; Moum, Bjørn & Vatn, Morten H (2008). Water supply and Inflammatory Bowel Disease based on a Norwegian cohort study from 1990-93 in South Eastern Norway. Gastroenterology.  ISSN 0016-5085.  134(4), s P-32- P-32 Vis sammendrag

  Sammenheng mellom jerninnhold i drikkevannskilden og økt forekomst av inflammatorisk tarmsykdom(Crohn's sykdom og ulcerøs colitt).

• Jelsness-Jørgensen, Lars-Petter; Bernklev, T; Jahnsen, Jørgen; Stavem, Knut; Kvien, Tore Kristian & Moum, Bjørn (2008). HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN IBD COMPARED TO OTHER CHRONIC DISEASES AND GENERAL POPULATION. Journal - Crohn's and Colitis Foundation of Canada.  ISSN 1197-4982.  2(1), s 33- 34
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Jahnsen, Jørgen; Vatn, Morten H; Stavem, Knut; Kvien, Tore Kristian & Moum, Bjørn (2007). HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN IBD COMPARED TO OTHER CHRONIC DISEASES AND GENERAL POPULATION.
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Mella, Bjarne; Sauar, Jostein; Jahnsen, Jørgen; Vatn, Morten H & Moum, Bjørn (2007). HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN PATIENTS WITH DIABETES MELLITUS COMPARED WITH PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND GENERAL POPULATION NORM. Journal - Crohn's and Colitis Foundation of Canada.  ISSN 1197-4982.  1(1)
• Bernklev, Tomm; Henriksen, Magne; Palm, Øivind; Jahnsen, Jørgen; Vatn, Morten H & Moum, Bjørn (2006). Are there other factors explaining why UC-patients with normal colonoskopy still reports IBD-related syptoms?. Gastroenterology.  ISSN 0016-5085.  130(4), s A653- A653
• Solberg, Inger; Jahnsen, Jørgen; Vatn, Morten H; Moum, Bjørn & Lygren, Idar (2006). Clinical course in Crohn's disease: A prospective population based follow-up study in southeastern Norway from January 1990 to december 2004 (The IBSEN Study). Gastroenterology.  ISSN 0016-5085.  130(4), s A85- A85

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