Gunnveig Grødeland

• Andersen, Tor Kristian; Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Fauskanger, Marte; Tveita, Anders Aune; Grødeland, Gunnveig & Bogen, Bjarne (2019). Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. npj Vaccines.  ISSN 2059-0105.  4:9, s 1- 13 . doi: 10.1038/s41541-019-0101-0 Fulltekst i vitenarkiv.
• Mooij, Petra; Grødeland, Gunnveig; Koopman, Gerrit; Andersen, Tor Kristian; Mortier, Daniella; Nieuwenhuis, Ivonne G.; Verschoor, Ernst J.; Fagrouch, Zahra; Bogers, Willy M. & Bogen, Bjarne (2019). Needle-free delivery of DNA: Targeting of hemagglutinin to MHC class II molecules protects rhesus macaques against H1N1 influenza. Vaccine.  ISSN 0264-410X.  37(6), s 817- 826 . doi: 10.1016/j.vaccine.2018.12.049
• Anderson, Ane Marie; Baranowska-Hustad, Marta Natalia; Braathen, Ranveig; Grødeland, Gunnveig & Bogen, Bjarne (2018). Simultaneous targeting of multiple hemagglutinins to APCs for induction of broad immunity against influenza. Journal of Immunology.  ISSN 0022-1767.  200(6), s 2057- 2066 . doi: 10.4049/jimmunol.1701088
• Braathen, Ranveig; Spång, Heidi Cecilie Larsen; Lindeberg, Mona Mari; Fossum, Even; Grødeland, Gunnveig; Fredriksen, Agnete & Bogen, Bjarne (2018). The Magnitude and IgG Subclass of Antibodies Elicited by Targeted DNA Vaccine Are Influenced by Specificity for APC Surface Molecules. ImmunoHorizons.  ISSN 2573-7732.  2(1), s 38- 53 . doi: 10.4049/immunohorizons.1700038 Fulltekst i vitenarkiv.
• Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne & Grødeland, Gunnveig (2017). A DNA vaccine that targets hemagglutinin to antigen-presenting cells protects mice against H7 influenza. Journal of Virology.  ISSN 0022-538X.  91:e01340-17(23), s 1- 13 . doi: 10.1128/JVI.01340-17 Fulltekst i vitenarkiv.
• Grødeland, Gunnveig; Fredriksen, Agnete; Løset, Geir Åge; Vikse, Elisabeth Lea; Fugger, Lars & Bogen, Bjarne (2016). Antigen targeting to human HLA Class II molecules increases efficacy of DNA vaccination. Journal of Immunology.  ISSN 0022-1767.  197(9), s 3575- 3585 . doi: 10.4049/jimmunol.1600893
• Lambert, Laura; Kinnear, Ekaterina; McDonald, Jacqueline U.; Grødeland, Gunnveig; Bogen, Bjarne; Stubsrud, Elisabeth; Lindeberg, Mona Mari; Fredriksen, Agnete & Tregoning, John S. (2016). DNA vaccines encoding antigen targeted to MHC class II induce influenza-specific CD8+ T cell responses, enabling faster resolution of influenza disease. Frontiers in Immunology.  ISSN 1664-3224.  7:321 . doi: 10.3389/fimmu.2016.00321
• Baranowska, Marta Natalia; Hauge, Anna G; Hoornaert, Chloe; Bogen, Bjarne & Grødeland, Gunnveig (2015). Targeting of nucleoprotein to chemokine receptors by DNA vaccination results in increased CD8(+)-mediated cross protection against influenza.. Vaccine.  ISSN 0264-410X.  33(49), s 6988- 6996 . doi: 10.1016/j.vaccine.2015.08.094 Vis sammendrag

  Vaccination is at present the most efficient way of preventing influenza infections. Currently used inactivated influenza vaccines can induce virus-neutralizing antibodies that are protective against a particular influenza strain, but hamper the induction of cross-protective T-cell responses to later infections. Thus, influenza vaccines need to be updated annually in order to confer protection against circulating influenza strains. This study aims at developing an efficient vaccine that can induce broader protection against influenza. For this purpose, we have used the highly conserved nucleoprotein (NP) from an influenza A virus subtype H7N7 strain, and inserted it into a vaccine format that targets an antigen directly to relevant antigen presenting cells (APCs). The vaccine format consists of bivalent antigenic and targeting units, linked via an Ig-based dimerization unit. In this study, NP was linked to MIP-1α, a chemokine that targets the linked antigen to chemokine receptors 1, 3 and 5 expressed on various APCs. The vaccine protein was indirectly delivered by DNA. Mice were vaccinated intradermally with plasmids, in combination with electroporation to enhance cellular uptake of DNA. We found that a single DNA vaccination was sufficient for induction of both antibody and T cell responses in BALB/c mice. Targeting of nucleoprotein to chemokine receptors enhanced T cell responses but not antibody responses. Moreover, a single dose of MIP1α-NP conferred protection in BALB/c mice against a lethal challenge with an H1N1 influenza virus. The observed cross-protection was mediated by CD8+ T cells.

• Fossum, Even; Grødeland, Gunnveig; Terhorst, Dorothea; Tveita, Anders; Vikse, Elisabeth Lea; Mjaaland, Siri; Henri, Sandrine; Malissen, Bernard & Bogen, Bjarne (2015). Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8+ T-cell responses against influenza virus. European Journal of Immunology.  ISSN 0014-2980.  45(2), s 624- 635 . doi: 10.1002/eji.201445080
• Grødeland, Gunnveig & Bogen, Bjarne (2015). Efficient vaccine against pandemic influenza: Combining DNA vaccination and targeted delivery to MHC class II molecules. Expert Review of Vaccines.  ISSN 1476-0584.  14(6), s 805- 814 . doi: 10.1586/14760584.2015.1029919
• Grødeland, Gunnveig; Fossum, Even & Bogen, Bjarne (2015). Polarizing T and B cell responses by APC-targeted subunit vaccines. Frontiers in Immunology.  ISSN 1664-3224.  6 . doi: 10.3389/fimmu.2015.00367
• Grødeland, Gunnveig; Mjaaland, Siri; Roux, Kenneth H.; Fredriksen, Agnete & Bogen, Bjarne (2013). DNA Vaccine that Targets Hemagglutinin to MHC Class II Molecules Rapidly Induces Antibody-Mediated Protection against Influenza. Journal of Immunology.  ISSN 0022-1767.  191(6), s 3221- 3231 . doi: 10.4049/jimmunol.1300504
• Grødeland, Gunnveig; Mjaaland, Siri; Tunheim, Gro; Fredriksen, Agnete & Bogen, Bjarne (2013). The Specificity of Targeted Vaccines for APC Surface Molecules Influences the Immune Response Phenotype. PLOS ONE.  ISSN 1932-6203.  8(11) . doi: 10.1371/journal.pone.0080008 Fulltekst i vitenarkiv.
• Ruffini, Pier Adelchi; Grødeland, Gunnveig; Fredriksen, Agnete & Bogen, Bjarne (2010). Human chemokine MIP1 alpha increases efficiency of targeted DNA fusion vaccines. Vaccine.  ISSN 0264-410X.  29(2), s 191- 199 . doi: 10.1016/j.vaccine.2010.10.057
• Huang, Tien-Sheng; Grødeland, Gunnveig; Grodeland, G; Sleire, Linda; Wang, Meng Yu; Kvalheim, Gunnar & Lærum, Ole Didrik (2009). Induction of Circadian Rhythm in Cultured Human Mesenchymal Stem Cells by Serum Shock and cAMP Analogs in Vitro. Chronobiology International.  ISSN 0742-0528.  26(2), s 242- 257 . doi: 10.1080/07420520902766025

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• Bjerkan, Louise; Braathen, Ranveig; Gudjonsson, Arnar; Grødeland, Gunnveig; Visweswaran, Ganesh Ram & Bogen, Bjarne (2018). An APC-targeted PfRH5 containing DNA vaccine induce protective immune responses against Plasmodium falciparum.
• Bjerkan, Louise; Braathen, Ranveig; Gudjonsson, Arnar; Grødeland, Gunnveig; Visweswaran, Ganesh Ram & Bogen, Bjarne (2018). Targeted DNA vaccination induce protective immune responses against malaria.
• Hinke, Daniëla Maria; Spång, Heidi; Fossum, Even; Grødeland, Gunnveig; Bogen, Bjarne & Braathen, Ranveig (2018). MHC class II targeted DNA vaccine is most efficient in the induction of protective antibodies against influenza. Vis sammendrag

  MHC class II targeted DNA vaccine is most efficient in the induction of protective antibodies against influenza

• Grødeland, Gunnveig; Fredriksen, Agnete; Mjaaland, Siri & Bogen, Bjarne (2011). Immunogenicity and Protective Efficacy of Targeted DNA Vaccine against Influenza. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 384- 384
• Hoornaert, Chloé Juliette; Grødeland, Gunnveig & Bogen, Bjarne (2011). Potential of Targeted DNA Vaccines against Conserved Influenza Proteins. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 387- 387
• Lindeberg, Mona Mari; Harandi, Ali M.; Thörn, Karolina; Grødeland, Gunnveig; Bogen, Bjarne; Brekke, Ole Henrik & Fredriksen, Agnete (2011). Vaccibodies as Proteins act as Effective Prophylactic Vaccines against Infectious Diseases. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 391- 391

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