Hilde Loge Nilsen

Bilde av Hilde Loge Nilsen
English version of this page
Brukernavn
Besøksadresse Sykehusveien 25 Akershus universitetssykehus 1478 Lørenskog Epigen B2 3et
Postadresse Akershus universitetssykehus 1478 Lørenskog

Mer informasjon finnes på den engelske versjonen av denne siden.

Faglige interesser

DNA reparasjon er det samlende fokus i gruppen. Vår hovedinteresse er et spesielt reparasjonsspor - base utkuttingsreparasjon - og betydningen av dette for å motvirke mutasjoner, kreft, neurodegenerative sykdommer og aldring.

Nåværende stillinger

  • 2009 - d.d: Professor Avdeling for Klinisk Molekylærbiologi, Campus Ahus
  • 2009 - 2013: Assisterende senterleder, Bioteknologisenteret i Oslo
  • 2006 - : Veileder ved problembasert læring-kurs, Medisinsk fakultet, Universitetet i Oslo
  • 2004 - 2013: Gruppeleder, Hilde Nilsen Group (DNA Repair), Bioteknologisenteret i Oslo

Bakgrunn

Forskning

  • 2000 - 2004: Postdoktor, London Research Institutes, Cancer Research UK, Storbritannia.
  • 1996 - 2000: Dr. Ingeniør, Norges teknisk Naturvitenskapelige Universitet, Trondheim
Emneord: DNA-skader, kreftbiologi, DNA-reparasjon

Publikasjoner

  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar & Kirpekar, Finn [Vis alle 10 forfattere av denne artikkelen] (2021). Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.762032.
  • Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi & Yang, Kuan [Vis alle 30 forfattere av denne artikkelen] (2021). DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis. ISSN 0021-9150. 324, s. 123–132. doi: 10.1016/j.atherosclerosis.2021.02.023.
  • SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Qin Ying; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo & Achanta, Kavya [Vis alle 14 forfattere av denne artikkelen] (2021). Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. Cell reports. ISSN 2211-1247. 36(10), s. 1–44. doi: 10.1016/j.celrep.2021.109668. Fulltekst i vitenarkiv
  • Følling, Ivar; Wennerström, Anna Berit; Eide, Tor Jacob & Nilsen, Hilde Loge (2021). Phaeochromocytomas overexpress insulin transcript and produce insulin. Endocrine Connections. ISSN 2049-3614. 10(8), s. 815–824. doi: 10.1530/EC-21-0269.
  • Gupta, Swapnil; You, Panpan; Sengupta, Tanima; Nilsen, Hilde & Sharma, Kulbhushan (2021). Crosstalk between Different DNA repair pathways contributes to neurodegenerative diseases. Biology (Basel). ISSN 2079-7737. 10(2). doi: 10.3390/biology10020163.
  • Bordin, Diana Lilian; Lirussi, Lisa & Nilsen, Hilde (2021). Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation. DNA Repair. ISSN 1568-7864. 99, s. 1–11. doi: 10.1016/j.dnarep.2021.103051.
  • Lirussi, Lisa; Demir, Özlem; You, Panpan; Sarno, Antonio; Amaro, Rommie E. & Nilsen, Hilde (2021). RNA metabolism guided by RNA modifications: The role of SMUG1 in rRNA quality control. Biomolecules. ISSN 2218-273X. 11(1), s. 1–22. doi: 10.3390/biom11010076. Fulltekst i vitenarkiv
  • Brorson, Ina Skaara; Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Vitelli, Valeria; Celius, Elisabeth Gulowsen & Luders, Torben [Vis alle 10 forfattere av denne artikkelen] (2020). CD8 + T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. doi: 10.1177/2055217320978511. Fulltekst i vitenarkiv
  • Aman, Yahyah; Frank, Johannes; Lautrup, Sofie Hindkjær; Matysek, Adrian; Niu, Zhangming & Yang, Guang [Vis alle 13 forfattere av denne artikkelen] (2020). The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications. Mechanisms of Ageing and Development. ISSN 0047-6374. 185, s. 1–11. doi: 10.1016/j.mad.2019.111194. Fulltekst i vitenarkiv
  • Safavi, Shiva; Larouche, Ariane; Zahn, Astrid; Patenaude, Anne-Marie; Domanska, Diana Ewa & Dionne, Kiersten [Vis alle 17 forfattere av denne artikkelen] (2020). The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. NAR Cancer. ISSN 2632-8674. 2(3). doi: 10.1093/narcan/zcaa019. Fulltekst i vitenarkiv
  • Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie & Aman, Yahyah [Vis alle 18 forfattere av denne artikkelen] (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development. ISSN 0047-6374. 186, s. 1–6. doi: 10.1016/j.mad.2020.111208. Fulltekst i vitenarkiv
  • Fang, Evandro Fei; Hou, Yujun; Hindkjær Lautrup, Sofie; Jensen, Martin Borch; Yang, Beimeng & Sengupta, Tanima [Vis alle 29 forfattere av denne artikkelen] (2019). NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nature Communications. ISSN 2041-1723. 10:5284, s. 1–18. doi: 10.1038/s41467-019-13172-8. Fulltekst i vitenarkiv
  • Malt, Eva Albertsen; Juhasz, Katalin; Frengen, Anna Brzozowska; Wangensteen, Urd Teresia; Emilsen, Nina Merete & Hansen, Børre [Vis alle 8 forfattere av denne artikkelen] (2019). Neuropsychiatric phenotype in relation to gene variants in the hemizygous allele in 3q29 deletion carriers: A case series. Molecular Genetics & Genomic Medicine. ISSN 2324-9269. 7(9). doi: 10.1002/mgg3.889. Fulltekst i vitenarkiv
  • Zheleva, Angelina; Gómez-Orte, Eva; Sáenz-Narciso, Beatriz; Ezcurra, Begoña; Kassahun, Henok & de Toro, María [Vis alle 10 forfattere av denne artikkelen] (2019). Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. PLoS Genetics. ISSN 1553-7390. 15:e1008338(9), s. 1–33. doi: 10.1371/journal.pgen.1008338. Fulltekst i vitenarkiv
  • Serebrenik, Artur A.; Starrett, Gabriel J.; Leenen, Sterre; Jarvis, Matthew C.; Shaban, Nadine M. & Salamango, Daniel J. [Vis alle 9 forfattere av denne artikkelen] (2019). The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(44), s. 22158–22163. doi: 10.1073/pnas.1904024116.
  • Lirussi, Lisa & Nilsen, Hilde (2019). Telomere maintenance: regulating hTERC fate through RNA modifications. Molecular and Cellular Oncology (MCO). ISSN 2372-3556. 6:1670489(6), s. 1–3. doi: 10.1080/23723556.2019.1670489. Fulltekst i vitenarkiv
  • Kroustallaki, Pinelopi; Lirussi, Lisa; Carracedo Huroz, Sergio; You, Panpan; Esbensen, Qin Ying & Götz, Alexandra [Vis alle 11 forfattere av denne artikkelen] (2019). SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing. Cell reports. ISSN 2211-1247. doi: 10.1016/j.celrep.2019.07.040. Fulltekst i vitenarkiv
  • Fang, Evandro Fei; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A.; Kerr, Jesse S. & Yang, Beimeng [Vis alle 20 forfattere av denne artikkelen] (2019). Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature Neuroscience. ISSN 1097-6256. 22(3), s. 401–412. doi: 10.1038/s41593-018-0332-9. Fulltekst i vitenarkiv
  • Nguyen, Chinh BKrong; Kumar, Surendra; Zucknick, Manuela; Kristensen, Vessela N.; Gjerstad, Johannes & Nilsen, Hilde Loge [Vis alle 7 forfattere av denne artikkelen] (2019). Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome. Brain, behavior, and immunity. ISSN 0889-1591. 76, s. 82–96. doi: 10.1016/j.bbi.2018.11.008. Fulltekst i vitenarkiv
  • Arczewska, Katarzyna D.; Stachurska, Anna; Wojewódzka, Maria; Karpińska, Kamila; Kruszewski, Marcin & Nilsen, Hilde Loge [Vis alle 7 forfattere av denne artikkelen] (2018). hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells. DNA Repair. ISSN 1568-7864. 69, s. 53–62. doi: 10.1016/j.dnarep.2018.07.006.
  • Torgovnick, Alessandro; Schiavi, Alfonso; Shaik, Anjumara; Kassahun, Henok; Maglioni, Silvia & Rea, Shane L [Vis alle 12 forfattere av denne artikkelen] (2018). BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans. EMBO Reports. ISSN 1469-221X. 19(12). doi: 10.15252/embr.201845856.
  • Kassahun, Henok; Sengupta, Tanima; Schiavi, Alfonso; Maglioni, Silvia; Skjeldam, Hanne Kim & Arczewska, Katarzyna [Vis alle 11 forfattere av denne artikkelen] (2018). Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans. DNA Repair. ISSN 1568-7864. 61, s. 46–55. doi: 10.1016/j.dnarep.2017.11.009. Fulltekst i vitenarkiv
  • Fang, Evandro Fei; Palikaras, Konstantinos; Sun, Nuo; Fivenson, Elayne M.; Spangler, Ryan D. & Kerr, Jesse S. [Vis alle 14 forfattere av denne artikkelen] (2017). In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. Journal of Visualized Experiments. ISSN 1940-087X. 2017(129). doi: 10.3791/56301.
  • Fang, Evandro Fei; Waltz, Tyler B.; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S. & Morevati, Marya [Vis alle 20 forfattere av denne artikkelen] (2017). Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/srep46208. Fulltekst i vitenarkiv
  • Fivenson, Elayne M.; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna & Nilsen, Hilde Loge [Vis alle 8 forfattere av denne artikkelen] (2017). Mitophagy in neurodegeneration and aging. Neurochemistry International. ISSN 0197-0186. 109, s. 202–209. doi: 10.1016/j.neuint.2017.02.007. Fulltekst i vitenarkiv
  • Holm, Kristine Lillebø; Syljuåsen, Randi G.; Hasvold, Grete; Alsøe, Lene; Nilsen, Hilde Loge & Ivanauskiene, Kristina [Vis alle 13 forfattere av denne artikkelen] (2017). TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLOS ONE. ISSN 1932-6203. 12(10). doi: 10.1371/journal.pone.0185708. Fulltekst i vitenarkiv
  • Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix & Lirussi, Lisa [Vis alle 16 forfattere av denne artikkelen] (2017). Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-07314-5. Fulltekst i vitenarkiv
  • Nguyen, Chinh Bkrong Thi Thuy; Alsøe, Lene; Lindvall, Jessica Margareta; Sulheim, Dag; Fagermoen, Frode Even & Winger, Anette [Vis alle 9 forfattere av denne artikkelen] (2017). Whole blood gene expression in adolescent chronic fatigue syndrome: An exploratory cross-sectional study suggesting altered B cell differentiation and survival. Journal of Translational Medicine. ISSN 1479-5876. 15. doi: 10.1186/s12967-017-1201-0. Fulltekst i vitenarkiv
  • Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja & Neurauter, Christine Gran [Vis alle 15 forfattere av denne artikkelen] (2017). No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/s41598-017-04472-4. Fulltekst i vitenarkiv
  • Scheibye-Knudsen, Morten; Tseng, Anne; Jensen, Martin Borch; Scheibye-Alsing, Karsten; Fang, Evandro Fei & Iyama, Teruaki [Vis alle 22 forfattere av denne artikkelen] (2016). Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 113(44), s. 12502–12507. doi: 10.1073/pnas.1610198113.
  • Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L.; Scheibye-Knudsen, Morten; Marosi, Krisztina & Lu, Huiming [Vis alle 22 forfattere av denne artikkelen] (2016). NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism. ISSN 1550-4131. 24(4), s. 566–581. doi: 10.1016/j.cmet.2016.09.004.
  • Fang, Evandro E; Wollman, B; Kassahun, Henok; Nilsen, Hilde; Scheibye-Knudsen, Morten & Bohr, Vilhelm A (2015). Nuclear DNA repair Proteins in Mitochondrial Health and Aging. Gerontology and geriatric medicine. ISSN 2333-7214. 1, s. 1–2.
  • Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima & Nilsen, Hilde [Vis alle 9 forfattere av denne artikkelen] (2014). Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction. Cell. ISSN 0092-8674. 157(4). doi: 10.1016/j.cell.2014.03.026.
  • Jobert, Laure & Nilsen, Hilde (2014). Regulatory mechanisms of RNA function: Emerging roles of DNA repair enzymes. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 71(13), s. 2451–2465. doi: 10.1007/s00018-014-1562-y.
  • Jobert, Laure; Skjeldam, Hanne Kim; Dalhus, Bjørn; Galashevskaya, Anastasia; Vågbø, Cathrine Broberg & Bjørås, Magnar [Vis alle 7 forfattere av denne artikkelen] (2013). The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Molecular Cell. ISSN 1097-2765. 49(2), s. 339–345. doi: 10.1016/j.molcel.2012.11.010.
  • Sengupta, Tanima; Torgersen, Maria Lyngaas; Kassahun, Henok; Vellai, Tibor; Simonsen, Anne & Nilsen, Hilde (2013). The Base Excision Repair AP-endonucleases functions in the same pathways as Mismatch Repair for Activation of Checkpoint Mediated Autophagy. Nature Communications. ISSN 2041-1723. 4. doi: 10.1038/ncomms3674.
  • Forthun, Rakel Brendsdal; Sengupta, Tanima; Skjeldam, Hanne Kim; Lindvall, Jessica Margareta; Mccormack, Emmet Martin & Gjertsen, Bjørn Tore [Vis alle 7 forfattere av denne artikkelen] (2012). Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. PLOS ONE. ISSN 1932-6203. 7(11). doi: 10.1371/journal.pone.0048992. Fulltekst i vitenarkiv
  • Tomazella, Gisele Guicardi; Kassahun, Henok; Nilsen, Hilde & Thiede, Bernd (2012). Quantitative Proteome Analysis Reveals RNA Processing Factors As Modulators of Ionizing Radiation-Induced Apoptosis in the C. elegans Germline. Journal of Proteome Research. ISSN 1535-3893. 11(8), s. 4277–4288. doi: 10.1021/pr300386z.
  • Erdélyi, Péter; Borsos, Éva; Takács-Vellai, Krisztina; Kovács, Tibor; Kovács, Attila L. & Sigmond, Tímea [Vis alle 15 forfattere av denne artikkelen] (2011). Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. Journal of Cell Science. ISSN 0021-9533. 124(9), s. 1510–1518. doi: 10.1242/jcs.080192.
  • Arczewska, Katarzyna; Baumeier, Christian; Kassahun, Henok; Sengupta, Tanima; Bjørås, Magnar & Kuśmierek, Jarosław T. [Vis alle 7 forfattere av denne artikkelen] (2011). Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair. ISSN 1568-7864. 10(2), s. 176–187. doi: 10.1016/j.dnarep.2010.10.009.
  • Arczewska, Katarzyna; Baumeier, Christian; Kassahun, Henok; Sengupta, Tanima; Bjørås, Magnar & Kuśmierek, Jarosław T. [Vis alle 7 forfattere av denne artikkelen] (2010). Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair. ISSN 1568-7864. doi: 10.1016/j.dnarep.2010.10.009.
  • Fensgård, Øyvind; Kassahun, Henok; Izabela Agnieszka, Bombik; Rognes, Torbjørn; Lindvall, Jessica Margareta & Nilsen, Hilde (2010). A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways. Aging. ISSN 1945-4589. Fulltekst i vitenarkiv
  • Skjeldam, Hanne Kim; Kassahun, Henok; Fensgård, Øyvind; Sengupta, Tanima; Babaie, Eshrat & Lindvall, Jessica Margareta [Vis alle 8 forfattere av denne artikkelen] (2010). Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents. DNA Repair. ISSN 1568-7864. 9(8), s. 861–870. doi: 10.1016/j.dnarep.2010.04.009.
  • Zakaria, Chadi; Kassahun, Henok; Yang, Xiaoming; Labbé, Jean-Claude; Nilsen, Hilde & Ramotar, Dindial (2010). Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability. DNA Repair. ISSN 1568-7864. 9(2), s. 169–176. doi: 10.1016/j.dnarep.2009.11.007.
  • Nilsen, Hilde; Corneliussen, Henriette; Fensgård, Øyvind; Grallert, Beata & Boye, Erik (2009). Global transcriptional response after exposure of fission yeast cells to ultraviolet light. BMC Cell Biology. ISSN 1471-2121. 10.
  • Nilsen, Hilde; Kassahun, Henok; Zakaria, Chadi; Yang, Xiaoming; Labbe, Jean-Claude & Ramotar, Dindial (2009). Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability. Accepted for publication in DNA repair, DNA Repair. ISSN 1568-7864. doi: 10.1016/j.dnarep.2009.11.007.
  • Nilsen, Hilde; Arczewska, Katarzyna; Michalickova, Katerina & Donaldson, Ian Matthew (2008). The contribution of DNA base damage to human cancer is modulated by the base excision repair interaction network. Critical reviews in oncogenesis. ISSN 0893-9675. 14(4), s. 217–273.
  • Schmidt, Frank; Strozynski, Margarita Anna; Salus, Sandra Suzanne; Nilsen, Hilde & Thiede, Bernd (2007). Rapid determination of amino acid incorporation by stable isotope labeling with amino acids in cell culture (SILAC). Rapid Communications in Mass Spectrometry. ISSN 0951-4198. 21, s. 3919–3926. doi: 10.1002/rcm.3290.
  • Dengg, Marlene; Garcia-Muse, Tatiana; Gill, Stephen G.; Ashcroft, Neville; Boulton, Simon j. & Nilsen, Hilde (2006). Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. EMBO Reports. ISSN 1469-221X. 7, s. 1046–1051. doi: 10.1038/sj.embor.7400782.
  • Andersen, Sonja Benedikte; Heine, T; Sneve, Ragnhild; Kønig, Imbritt; Krokan, Hans Einar & Epe, B [Vis alle 7 forfattere av denne artikkelen] (2005). Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis. ISSN 0143-3334. 26(3), s. 547–555. doi: 10.1093/carcin/bgh347.
  • Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G & Nilsen, Hilde [Vis alle 8 forfattere av denne artikkelen] (2005). Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair. ISSN 1568-7864. 4(12), s. 1432–1441.
  • Nilsen, Hilde; An, Q & Lindahl, T (2005). Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice. Oncogene. ISSN 0950-9232. 24(18), s. 3063–3066.
  • Andersen, S; Heine, T; Sneve, Ragnhild; Konig, I; Krokan, HE & Epe, B [Vis alle 7 forfattere av denne artikkelen] (2005). Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis. ISSN 0143-3334. 26(3), s. 547–555.
  • Nilsen, Hilde; An, Q & Lindahl, T (2004). Mutation frequenceies and AID activation state in B-cell lymphomas from Ung-deficient mice. Oncogene. ISSN 0950-9232.
  • Nilsen, Hilde; Stamp, G; Andersen, Sonja; Hrivnak, G; Krokan, Hans Einar & Lindahl, T [Vis alle 7 forfattere av denne artikkelen] (2003). Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene. ISSN 0950-9232. 22, s. 5381–5386.
  • Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde & Skorpen, Frank [Vis alle 10 forfattere av denne artikkelen] (2002). hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry. ISSN 0021-9258. 18, s. 39926–39936.
  • Kvaløy, Kirsti; Nilsen, H.; Steinsbekk, Kristin; Nedal, Aina; Monterotti, Bruno & Akbari, Mansour [Vis alle 7 forfattere av denne artikkelen] (2001). Sequence variation in the human uracil-DNA glycosylase (UNG) gene. Mutation Research (DNA Repair). ISSN 0921-8777. 461(4), s. 325–338. doi: 10.1016/S0921-8777%2800%2900063-X%2C.
  • Krokan, Hans Einar & Nilsen, Hilde (2001). Base excision repair in a network of defence and tolerance. Carcinogenesis. ISSN 0143-3334. 22(Nr 7), s. 987–998.
  • Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank & Andersen, Sonja [Vis alle 10 forfattere av denne artikkelen] (2001). Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology. ISSN 0079-6603. 68, s. 365–386.

Se alle arbeider i Cristin

  • Bos, Steffan Daniel; Brorson, Ina Skaara; Eriksson, Anna; Leikfoss, Ingvild Sørum; Vitelli, Valeria & Celius, Elisabeth Gulowsen [Vis alle 10 forfattere av denne artikkelen] (2019). Differential gene expression analysis of CD8+ T cells from multiple sclerosis patients and healthy controls .
  • Hindkjær Lautrup, Sofie; Lou, Guofeng; Aman, Yahyah; Nilsen, Hilde; Tao, Jun & Fang, Evandro Fei (2019). Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease. Neurochemistry International. ISSN 0197-0186. 129. doi: 10.1016/j.neuint.2019.104469.
  • Gudmundsrud, Ruben; Lautrup, Sofie; Nilsen, Hilde Loge; Bohr, Vilhelm & Fang, Fei (2018). Mitofagi i nevrodegenerasjon og aldring. BestPractice Norge. 109, s. 202–209. doi: 10.1016/j.neuint.2017.02.007.
  • Høyer, Helle; Tveten, Kristian; Røsby, Oddveig; Hilmarsen, Hilde T; Busk, Øyvind & Svendsen, Marit [Vis alle 12 forfattere av denne artikkelen] (2018). A novel AARS variant identified in three CMT2 families.
  • Alsøe, Lene; Wennerström, Anna Berit; Liu, Yan; Esbensen, Qin Ying; Bjørset, Randi & Penz, Christine [Vis alle 10 forfattere av denne artikkelen] (2018). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
  • Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix & Lirussi, Lisa [Vis alle 16 forfattere av denne artikkelen] (2017). Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1 .
  • Alsøe, Lene; Wennerstrøm, Anna; Liu, Yan; Esbensen, Qin Ying; Bjørseth, Randi & Penz, Christine [Vis alle 10 forfattere av denne artikkelen] (2017). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
  • Sarno, Antonio; Alsøe, Lene; Carracedo, Sergio; Tekin, Nuriya Basdag; Gupta, Tanima Sen & Jobert, Laure [Vis alle 9 forfattere av denne artikkelen] (2016). UNG and SMUG1 complement each other in DNA uracil excision and DNA 5-hydroxymethyluracil originates from 5-hydroxymethylcytosine deamination in mice.
  • Nilsen, Hilde; Kroustallaki, Pinelopi; Alsøe, Lene; Huroz, Sergio C; Sarno, Antonio & Esbensen, Ying [Vis alle 11 forfattere av denne artikkelen] (2016). Telomere maintenance defects in mice deficient in SMUG1 uracil-DNA glycosylase.
  • Wyller, Vegard Bruun; Jacobsen, Kristine; Dahl, Mai Britt; Nilsen, Hilde; Proske, Simone & Horter, Thorsten [Vis alle 7 forfattere av denne artikkelen] (2016). Interferon gamma may improve cardiac function in Friedreich's ataxia cardiomyopathy. International Journal of Cardiology. ISSN 0167-5273. 221, s. 376–378. doi: 10.1016/j.ijcard.2016.06.288.
  • Nilsen, Hilde (2013). Kan denne ormen avsløre at vitaminbruk er bortkastet. Aftenposten Innsikt. ISSN 1890-6931.
  • Nilsen, Hilde & Nickelsen, Trine (2013). Vitaminpiller kan skade kroppens eget forsvar. Apollon : Forskningsmagasin for Universitetet i Oslo. ISSN 0803-6926.
  • Nilsen, Hilde (2012). Liten orm gir mer effektiv kreftmedisin. Forskning.no. ISSN 1891-635X.
  • Nilsen, Hilde (2010). Om forsknings arbeider i Bioteknologisenteret. [TV]. NRK Østlandssendningen.
  • Nilsen, Hilde (2010). Liten orm hjelper oss til bedre liv. [Avis]. Aftenposten.
  • Nilsen, Hilde (2010). Liten orm avslører våre aldringsprosesser. [Avis]. Apollon.
  • Nilsen, Hilde (2010). DNA repair dependent signalling of cell death responses to 5-Fluorouracil.
  • Nilsen, Hilde (2010). A two-tiered compensatory response to loss of DNA repair modulated aging and stress-response pathways.
  • Nilsen, Hilde (2010). A two-tiered compensatory response to loss of DNA repair modulated aging and stress-response pathways.
  • Fensgård, Øyvind & Nilsen, Hilde (2010). DNA skader aldringsprosessen. NBS-nytt. ISSN 0801-3535. s. 9–13.
  • Fensgård, Øyvind; Lindvall, Jessica Margareta; Kassahun, Henok; Rognes, Torbjørn & Nilsen, Hilde (2009). Microarray analysis of BER mutants.
  • Nilsen, Hilde (2009). Uracil DNA glycosylase is required for apoptosis in response to 5-fluorouracil in C. elegans.
  • Nilsen, Hilde (2009). DNA repair modulates responses to chemotherapeutic agents.
  • Nilsen, Hilde (2009). Two-tiered response to loss of DNA damage in C. elegans.
  • Fensgård, Øyvind; Lindvall, Jessica; Kassahun, Henok; Rognes, Torbjørn & Nilsen, Hilde (2009). Microarray analysis of BER mutants.
  • Nilsen, Hilde & Dengg, Marlene (2006). Caenorhabditis elegans and the DNA damage response. NBS-nytt. ISSN 0801-3535. 30(3), s. 22–25.
  • Nilsen, Hilde (2005). Cellular responses to endogenous DNA damage.
  • Nilsen, Hilde (2005). Using C.elegans to study the DNA damage response”.
  • Nilsen, Hilde (2005). Using Caenorhabditis elegans to study cellular responses to endogenous DNA damage.
  • Nilsen, Hilde (2005). Genetic studies of repair of endogenous DNA damage.
  • Nilsen, Hilde (2005). Using C.elegans to study the DNA damage response.
  • Nilsen, Hilde (2004). The UNG uracil -NDA glycosylase- a region specific guardian of the genome.
  • Nilsen, Hilde (2004). The UNG uracil-DNA glycosylase- a region specific guardian of the genome.
  • Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R & Slupphaug, Geir [Vis alle 11 forfattere av denne artikkelen] (2002). "URACIL-DNAGLYCOSYLASE KNOCKOUT MICE-effects on lifespan and health. Characterisation of uracil removing activities in wild type and Ung deficient mice.".
  • Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde & Aas, Per Arne [Vis alle 8 forfattere av denne artikkelen] (2002). Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup.
  • Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R & Slupphaug, Geir [Vis alle 7 forfattere av denne artikkelen] (2002). Uracil-DNA glycosylase knockout mice.
  • Slupphaug, Geir; Skorpen, Frank; Nilsen, H.; Fenstad, M.; Rosello, Ch. & Otterlei, Marit [Vis alle 8 forfattere av denne artikkelen] (2001). Functional implications of the UNG2 regulatory domain in BER and transcription regulation.
  • Nilsen, H.; Robins, P; Haushalters, K.; Krokan, Hans Einar; Verdine, G. & Barnes, D. [Vis alle 7 forfattere av denne artikkelen] (2001). Base excision repair of uracil in mammalian cells.
  • Nilsen, Hilde; Roswell, Ian; Robins, Peter; Slupphaug, Geir; Steinsbekk, Kristin & Otterlei, Marit [Vis alle 10 forfattere av denne artikkelen] (2000). Characterisation Of The Major Murine Uracil-DNA Glycosylase And Expression Patterns And Generation of ung/-Knockout Mice.
  • Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank & Andersen, Sonja [Vis alle 9 forfattere av denne artikkelen] (2000). Structure-function aspects of human uracil-DNA glycosylase and its interactions with other proteins.
  • Fensgård, Øyvind & Nilsen, Hilde (2010). Global Genome Responses to DNA-Repair Deficiency Modulate Aging and Stress Response Pathways. Unipud. ISSN 978-82-8264-118-0.

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Publisert 4. sep. 2013 12:55 - Sist endret 28. apr. 2017 08:18