Jan Terje Andersen

Førsteamanuensis - Avdeling for farmakologi
Bilde av Jan Terje Andersen
English version of this page
Telefon +47-22857275
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postadresse Postboks 1057 Blindern 0316 OSLO

About The Laboratory of Adaptive Immunity and Homeostasis

The research group is studying the cellular processes and molecular interplay underlying the functions of the two most abundant proteins in blood, albumin and IgG. Such knowledge offers opportunities for development of novel concepts that will secure improved half-life and biodistribution of IgG and albumin based therapeutics. The laboratory has an eye on translational research, is highly innovative and is the research group at the University of Oslo and Oslo University Hospital with most registered innovations at Inven2. The laboratory is collaborating extensively with biotech and pharmaceutical companies. The head of the laboratory, Jan Terje Andersen, has obtained the Fridtjof Nansen Prize for Early Career Achievements, Oslo University Hospital Early Career Award and is a member of The Young Academy of Norway.  

Projects

A) Studies of the interactions of antibodies with their Fc receptors, with a particular focus on the neonatal Fc receptor (FcRn) and its relationship with IgG and albumin. In addition, we are investigating how FcRn acts as a transporter in different cell types of the body. The studies will unravel the basic structural and cellular mechanisms that govern the functions of FcRn. Such knowledge offers opportunities for development of novel drug concepts that will secure improved half-life and biodistribution.

B) Studies of the mechanisms of infections at different body sites and how humoral immunity fights and restricts infection and virus replication. In particular, we are studying how antibodies contribute to protection against infectious diseases, and how FcRn and tripartite motif containing 21 (TRIM21) take part in cellular protection. Such knowledge can be utilized to develop novel antibody technologies tailored to combat infectious diseases.

 

For more information, please visit:

www.ous-research.no/andersen/

Facebook profile 

Linkedin profile

Twitter: @Andersen JT

 

The Young Academy of Norway:

http://akademietforyngreforskere.no/medlem/jan-terje-andersen/

 

 

 

 

 

 

Publikasjoner

  • Shaw, Alan; Hoffecker, Ian T.; Smyrlaki, Ioanna; Rosa, João; Grevys, Algirdas; Bryant-Bratlie, Diane Lynn; Sandlie, Inger; Michaelsen, Terje Einar; Andersen, Jan Terje & Högberg, Björn (2019). Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies. Nature Nanotechnology.  ISSN 1748-3387.  14(2), s 184- 190 . doi: 10.1038/s41565-018-0336-3
  • Bottermann, Maria; Foss, Stian; van Tienen, Laurens M.; Vaysburd, Marina; Cruickshank, James; O’Connell, Kevin; Clark, Jessica; Mayes, Keith; Higginson, Katie; Hirst, Jack C.; McAdam, Martin Berner; Slodkowicz, Greg; Hutchinson, Edward; Kozik, Patrycja; Andersen, Jan Terje & James, Leo C. (2018). TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  115(41), s 10440- 10445 . doi: 10.1073/pnas.1806314115 Vis sammendrag
  • Grevys, Algirdas; Nilsen, Jeannette; Sand, Kine Marita Knudsen; Daba, Muluneh Bekele; Øynebråten, Inger; Bern, Malin C.; McAdam, Martin Berner; Foss, Stian; Schlothauer, Tilman; Michaelsen, Terje Einar; Christianson, Gregory J.; Roopenian, Derry C.; Blumberg, Richard S.; Sandlie, Inger & Andersen, Jan Terje (2018). A human endothelial cell-based recycling assay for screening of FcRn targeted molecules. Nature Communications.  ISSN 2041-1723.  9 . doi: 10.1038/s41467-018-03061-x Fulltekst i vitenarkiv.
  • Nilsen, Jeannette; Bern, Malin C.; Sand, Kine Marita Knudsen; Grevys, Algirdas; Dalhus, Bjørn; Sandlie, Inger & Andersen, Jan Terje (2018). Human and mouse albumin bind their respective neonatal Fc receptors differently. Scientific Reports.  ISSN 2045-2322.  8:14648, s 1- 12 . doi: 10.1038/s41598-018-32817-0 Fulltekst i vitenarkiv.
  • Nilsen, Jeannette; Sandlie, Inger; Roopenian, Derry C. & Andersen, Jan Terje (2018). Animal models for evaluation of albumin-based therapeutics. Current Opinion in Chemical Engineering.  ISSN 2211-3398.  19, s 68- 76 . doi: 10.1016/j.coche.2017.11.007 Fulltekst i vitenarkiv. Vis sammendrag
  • Sivertsen, Magne S.; Jørstad, Øystein Kalsnes; Grevys, Algirdas; Foss, Stian; Moe, Morten Carsten & Andersen, Jan Terje (2018). Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties. Scientific Reports.  ISSN 2045-2322.  8(1) . doi: 10.1038/s41598-018-20525-8
  • Stapleton, Nigel M.; Armstrong-Fisher, Sylvia S.; Andersen, Jan Terje; van der Schoot, C. Ellen; Porter, Charlene; Page, Kenneth R.; Falconer, Donald; de Haas, Masja; Williamson, Lorna M.; Clark, Michael R.; Vidarsson, Gestur & Armour, Kathryn L. (2018). Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport. Molecular Immunology.  ISSN 0161-5890.  95, s 1- 9 . doi: 10.1016/j.molimm.2018.01.006
  • Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E.; Foss, Stian; Sandlie, Inger; Andersen, Jan Terje & James, Leo C. (2017). Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity. Scientific Reports.  ISSN 2045-2322. . doi: 10.1038/srep45418 Fulltekst i vitenarkiv.
  • Cardoso, Ines Do Rosario; Østerlund, Eva Christina; Stamnæs, Jorunn; Iversen, Rasmus; Andersen, Jan Terje; Jørgensen, Thomas J D & Sollid, Ludvig Magne (2017). Dissecting the interaction between transglutaminase 2 and fibronectin. Amino Acids.  ISSN 0939-4451.  49(3), s 489- 500 . doi: 10.1007/s00726-016-2296-y Fulltekst i vitenarkiv.
  • Pyzik, Michal; Rath, Timo; Kuo, Timothy T.; Win, Sanda; Baker, Kristi; Hubbard, Jonathan J.; Grenha, Rosa; Gandhi, Amit; Krämer, Thomas D.; Mezo, Adam R.; Taylo, Zachary S.; McDonnell, Kevin; Nienaber, Vicki; Andersen, Jan Terje; Mizoguchi, Atsushi; Blumberg, Laurence; Purohit, Shalaka; Jones, Susan D.; Christianson, Gregory J.; Lencer, Wayne I.; Sandlie, Inger; Kaplowitz, Neil; Roopenian, Derry C. & Blumberg, Richard S. (2017). Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  114(14), s E2862- E2871 . doi: 10.1073/pnas.1618291114 Fulltekst i vitenarkiv.
  • Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E; Foss, Stian; Sandlie, Inger; Andersen, Jan Terje & James, Leo C. (2016). Antibody-antigen kinetics constrain intracellular humoral immunity. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep37457 Fulltekst i vitenarkiv.
  • Foss, Stian; Grevys, Algirdas; Sand, Kine Marita Knudsen; Bern, Malin C.; Blundell, Pat; Michaelsen, Terje Einar; Pleass, Richard J.; Sandlie, Inger & Andersen, Jan Terje (2016). Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization. Journal of Controlled Release.  ISSN 0168-3659.  223, s 42- 52 . doi: 10.1016/j.jconrel.2015.12.033 Fulltekst i vitenarkiv.
  • Foss, Stian; Watkinson, Ruth E; Grevys, Algirdas; Mc, Adam Martin Berner; Bern, Malin C.; Høydahl, Lene Støkken; Dalhus, Bjørn; Michaelsen, Terje Einar; Sandlie, Inger; James, Leo C & Andersen, Jan Terje (2016). TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity. Journal of Immunology.  ISSN 0022-1767.  196(8), s 3452- 3459 . doi: 10.4049/jimmunol.1502601 Fulltekst i vitenarkiv.
  • Almåsbak, Hilde Kjersti; Walseng, Even; Kristian, Alexandr; Myhre, Marit Renee; Suso, Else Marit Inderberg; Munthe, Ludvig Andre; Andersen, Jan Terje; Wang, Mari; Kvalheim, Gunnar; Gaudernack, Gustav & Kyte, Jon A (2015). Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model. Gene Therapy.  ISSN 0969-7128.  22(5), s 391- 403 . doi: 10.1038/gt.2015.4
  • Bern, Malin C.; Sand, Kine Marita Knudsen; Nilsen, Jeannette; Sandlie, Inger & Andersen, Jan Terje (2015). The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery. Journal of Controlled Release.  ISSN 0168-3659.  211, s 144- 162 . doi: 10.1016/j.jconrel.2015.06.006
  • Cardoso, Ines Do Rosario; Stamnæs, Jorunn; Andersen, Jan Terje; Melino, Gerry; Iversen, Rasmus & Sollid, Ludvig Magne (2015). Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies. The FEBS Journal.  ISSN 1742-464X.  282(11), s 2063- 2075 . doi: 10.1111/febs.13276
  • Daniel M, Czajkowsky; Andersen, Jan Terje; Fuchs, Anja; Wilson, Timothy J; Mekhaiel, David; Colonna, Marco; He, Jianfeng; Shao, Zhifeng; Mitchell, Daniel A.; Wu, Gang; Dell, Anne; Haslam, Stuart; Lloyd, Katy A.; Moore, Shona C.; Sandlie, Inger; Blundell, Patricia A. & Pleass, Richard J. (2015). Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications. Scientific Reports.  ISSN 2045-2322.  5, s 1- 11 . doi: 10.1038/srep09526 Fulltekst i vitenarkiv.
  • Foss, Stian; Watkinson, Ruth; Sandlie, Inger; James, Leo C. & Andersen, Jan Terje (2015). TRIM21: A cytosolic Fc receptor with broad antibody isotype specificity. Immunological Reviews.  ISSN 0105-2896.  268(1), s 328- 339 . doi: 10.1111/imr.12363 Fulltekst i vitenarkiv.
  • Grevys, Algirdas; Bern, Malin C.; Foss, Stian; Bratlie, Diane Lynn Bryant; Moen, Anders; Gunnarsen, Kristin Støen; Aase, Audun; Michaelsen, Terje Einar; Sandlie, Inger & Andersen, Jan Terje (2015). Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions. Journal of Immunology.  ISSN 0022-1767.  194(11), s 5497- 5508 . doi: 10.4049/jimmunol.1401218 Fulltekst i vitenarkiv.
  • Hallstensen, Randi; Bergseth, Grete; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Thobias; Holt, jan; Christiansen, Dorte; Lau, Corinna; Brekke, Ole Lars; Armstrong, Elina; Stefanovic, Vedran; Andersen, Jan Terje; Sandlie, Inger & Mollnes, Tom Eirik (2015). Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn. Immunobiology.  ISSN 0171-2985.  220(4), s 452- 459 . doi: 10.1016/j.imbio.2014.11.003 Fulltekst i vitenarkiv.
  • Sand, Kine Marita Knudsen; Bern, Malin C.; Nilsen, Jeannette; Noordzij, Hanna Theodora; Sandlie, Inger & Andersen, Jan Terje (2015). Unraveling the interaction between FcRn and albumin: Opportunities for design of albumin-based therapeutics. Frontiers in Immunology.  ISSN 1664-3224.  5:682 . doi: 10.3389/fimmu.2014.00682 Fulltekst i vitenarkiv.
  • Xi, Chien; Hnida, Kathrin; Graewert, Melissa Ann; Andersen, Jan Terje; Iversen, Rasmus; Tuukkanen, Anne; Svergun, Dmitri & Sollid, Ludvig Magne (2015). Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease. Journal of Biological Chemistry.  ISSN 0021-9258.  290(35), s 21365- 21375 . doi: 10.1074/jbc.M115.669895
  • Andersen, Jan Terje; Dalhus, Bjørn; Viuff, Dorthe; Ravn, Birgitte Thue; Gunnarsen, Kristin Støen; Plumridge, Andrew; Bunting, Karen; Antunes, Filipa; Williamson, Rebecca; Athwal, Steven; Allan, Elizabeth; Evans, Leslie; Bjørås, Magnar; Kjærulff, Søren; Sleep, Darrell; Sandlie, Inger & Cameron, Jason (2014). Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding. Journal of Biological Chemistry.  ISSN 0021-9258.  289(19), s 13492- 13502 . doi: 10.1074/jbc.M114.549832 Fulltekst i vitenarkiv.
  • Andersen, Jan Terje; Hjelstuen, Ole Kristian & Sandlie, Inger (2014). From Basic Research to Innovation, In  Medical Technology - Meeting Tomorrow's Health Care Challenges.  Novus Forlag.  ISBN 978-82-7099-791-6.  3.  s 39 - 50
  • Einarsdottir, Helga K.; Stapleton, Nigel M.; Scherjon, Sicco; Andersen, Jan Terje; Rispens, Theo; van der Schoot, C. Ellen & Vidarsson, Gestur (2014). On the perplexingly low rate of transport of IgG2 across the human placenta. PLoS ONE.  ISSN 1932-6203.  9(9) . doi: 10.1371/journal.pone.0108319
  • Rahman, Mohummad Aminur; Kristiansen, Per Eugen; Veiseth, Silje Veie; Andersen, Jan Terje; Yap, Kyoko L.; Zhou, Ming-Ming; Sandlie, Inger; Thorstensen, Tage & Aalen, Reidunn B. (2014). The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Biochemistry.  ISSN 1520-4995.  53(13), s 2091- 2100 . doi: 10.1021/bi401436h
  • Sand, Kine Marita Knudsen; Bern, Malin C.; Nilsen, Jeannette; Dalhus, Bjørn; Gunnarsen, Kristin Støen; Cameron, Jason; Grevys, Algirdas; Bunting, Karen; Sandlie, Inger & Andersen, Jan Terje (2014). Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc Receptor (FcRn). Journal of Biological Chemistry.  ISSN 0021-9258.  289(50), s 34583- 34594 . doi: 10.1074/jbc.M114.587675
  • Sand, Kine Marita Knudsen; Dalhus, Bjørn; Christianson, Gregory J.; Bern, Malin C.; Foss, Stian; Cameron, Jason; Sleep, Darrell; Bjørås, Magnar; Roopenian, Derry C; Sandlie, Inger & Andersen, Jan Terje (2014). Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies. Journal of Biological Chemistry.  ISSN 0021-9258.  289(24), s 17228- 17239 . doi: 10.1074/jbc.M113.522565 Fulltekst i vitenarkiv.
  • Andersen, Jan Terje; Cameron, J; Plumridge, A; Sleep, D; Evans, L & Sandlie, Inger (2013). Single-chain Variable Fragment Albumin Fusions Bind the Neonatal Fc Receptor (FcRn) in a Species-dependent Manner: IMPLICATIONS FOR IN VIVO HALF-LIFE EVALUATION OF ALBUMIN FUSION THERAPEUTICS. Journal of Biological Chemistry.  ISSN 0021-9258.  288(33), s 24277- 24285 . doi: 10.1074/jbc.M113.463000 Fulltekst i vitenarkiv.
  • Andersen, Jan Terje; Gonzalez-Pajuelo, Maria; Foss, Stian; Landsverk, Ole J. B.; Pinto, Debora; Szyroki, Alexander; de Haard, Hans J.; Saunders, Michael; Vanlandschoot, Peter & Sandlie, Inger (2013). Selection of Nanobodies that Target Human Neonatal Fc Receptor. Scientific Reports.  ISSN 2045-2322.  3 . doi: 10.1038/srep01118 Fulltekst i vitenarkiv.
  • Jacobsen, Johanne Tracey; Gjerstad, Vibeke Sundvold; Skjeldal, Frode Miltzow; Andersen, Jan Terje; Abrahamsen, Greger; Bakke, Oddmund; Spurkland, Anne & Bogen, Bjarne (2013). B-cell tolerance to the B-cell receptor variable regions. European Journal of Immunology.  ISSN 0014-2980.  43(10), s 2577- 2587 . doi: 10.1002/eji.201243203
  • Jung, Sang Taek; Kelton, William; Kang, Tae Hyun; T.W. Ng, Daphne; Andersen, Jan Terje; Sandlie, Inger; Sarkar, Casim A. & Georgiou, George (2013). Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High FcγRIIa Affinity and Selectivity. ACS Chemical Biology.  ISSN 1554-8929.  8(2), s 368- 375 . doi: 10.1021/cb300455f
  • Lau, Corinna; Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Andersen, Jan Terje; Berntzen, Gøril; Pharo, Anne Margrethe; Lindstad, Julie Katrine; Ludviksen, Judith K; Brekke, Ole Lars; Barratt-Due, Andreas; Nielsen, Erik Waage; Stokes, Christopher R.; Espevik, Terje; Sandlie, Inger & Mollnes, Tom Eirik (2013). Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation. Journal of Immunology.  ISSN 0022-1767.  191(9), s 4769- 4777 . doi: 10.4049/jimmunol.1301653 Fulltekst i vitenarkiv.
  • Mathiesen, Line; Nielsen, Leif K.; Andersen, Jan Terje; Grevys, Algirdas; Sandlie, Inger; Michaelsen, Terje Einar; Hedegaard, Morten; Knudsen, Lisbeth E. & Dziegiel, Morten Hanefeld (2013). Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions. Blood.  ISSN 0006-4971.  122(7), s 1174- 1181 . doi: 10.1182/blood-2012-12-473843 Fulltekst i vitenarkiv.
  • Yazaki, Paul J.; Lee, Brian; Channappal, Divya; Cheung, Chia-Wei; Crow, Desiree; Chea, Junie; Erasmus, Poku; Li, Lin; Andersen, Jan Terje; Sandlie, Inger; Orcutt, Kelly Davis; Wittrup, K.Dane; Shively, John E; Raubitschek, Andrew & Colcher, David (2013). A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance. Protein Engineering Design & Selection.  ISSN 1741-0126.  26(3), s 187- 193 . doi: 10.1093/protein/gzs096
  • Andersen, Jan Terje; Dalhus, Bjørn; Cameron, Jason; Daba, Muluneh Bekele; Plumridge, Andrew; Evans, Leslie; Brennan, Stephen O.; Gunnarsen, Kristin Støen; Bjørås, Magnar; Sleep, Darrell & Sandlie, Inger (2012). Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor. Nature Communications.  ISSN 2041-1723.  3 . doi: 10.1038/ncomms1607 Fulltekst i vitenarkiv.
  • Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum; Roopenian, Derry C; Wu, Anna M & Sandlie, Inger (2012). Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life. Journal of Biological Chemistry.  ISSN 0021-9258.  287(27), s 22927- 22937 . doi: 10.1074/jbc.M112.355131 Fulltekst i vitenarkiv.
  • Andersen, Jan Terje; Pehrson, Rikard; Tolmachev, Vladimir; Daba, Muluneh Bekele; Abrahamsen, Lars & Ekblad, Caroline (2011). Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain. Journal of Biological Chemistry.  ISSN 0021-9258.  286(7), s 5234- 5241 . doi: 10.1074/jbc.M110.164848
  • Baker, Kristi; Qiao, Shuo Wang; Kuo, Timothy T.; Aveson, Victoria G.; Platzer, Barbara; Andersen, Jan Terje; Sandlie, Inger; Chen, Zhangguo; de Haar, Colin; Lencer, Wayne I.; Fiebiger, Edda & Blumberg, Richard S. (2011). Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8(-)CD11b(+) dendritic cells. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(24), s 9927- 9932 . doi: 10.1073/pnas.1019037108
  • Mekhaiel, David N. A.; Czajkowsky, Daniel M.; Andersen, Jan Terje; Shi, Jianguo; El-Faham, Marwa; Doenhoff, Michael; McIntosh, Richard S.; Sandlie, Inger; He, Jianfeng; Hu, Jun; Shao, Zhifeng & Pleass, Richard J. (2011). Polymeric human Fc-fusion proteins with modified effector functions. Scientific Reports.  ISSN 2045-2322.  1 . doi: 10.1038/srep00124 Fulltekst i vitenarkiv.
  • Stapleton, NM; Andersen, Jan Terje; Stemerding, AM; Bjarnarson, SP; Verheul, RC; Gerritsen, J.; Zhao, Y; Kleijer, M; Sandlie, Inger; de Haas, Masja; Jonsdottir, I; van der Schoot, CE & Vidarsson, G. (2011). Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential. Nature Communications.  ISSN 2041-1723.  2 . doi: 10.1038/ncomms1608 Fulltekst i vitenarkiv. Vis sammendrag
  • Andersen, Jan Terje; Daba, Muluneh Bekele; Berntzen, Gøril; Michaelsen, Terje Einar & Sandlie, Inger (2010). Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding. Journal of Biological Chemistry.  ISSN 0021-9258.  285(7), s 4826- 4836 . doi: 10.1074/jbc.M109.081828 Fulltekst i vitenarkiv.
  • Andersen, Jan Terje; Daba, Muluneh Bekele & Sandlie, Inger (2010). FcRn binding properties of an abnormal truncated analbuminemic albumin variant. Clinical Biochemistry.  ISSN 0009-9120.  43(4-5), s 367- 372 . doi: 10.1016/j.clinbiochem.2009.12.001
  • Andersen, Jan Terje & Sandlie, Inger (2009). The Versatile MHC Class I-related FcRn Protects IgG and Albumin from Degradation: Implications for Development of New Diagnostics and Therapeutics. Drug Metabolism and Pharmacokinetics.  ISSN 1347-4367.  24(4), s 318- 332
  • Berntzen, Gøril; Andersen, Jan Terje; Ustgård, Kristine; Ustgård, Kristine; Michaelsen, Terje Einar; Mousavi, Darbi Seyed Ali; Mousavi, Seyed Ali; Qian, Julie Dee; Qian, Julie Dee; Kristiansen, Per Eugen; Kristiansen, Per Eugen; Lauvrak, Vigdis & Sandlie, Inger (2009). Identification of a High Affinity Fc gamma RIIA-binding Peptide That Distinguishes Fc gamma RIIA from Fc gamma RIIB and Exploits Fc gamma RIIA-mediated Phagocytosis and Degradation. Journal of Biological Chemistry.  ISSN 0021-9258.  284(2), s 1126- 1135 . doi: 10.1074/jbc.M803584200 Fulltekst i vitenarkiv.
  • Andersen, Jan T; Justesen, Sune; Fleckenstein, Burkhard; Michaelsen, Terje Einar; Berntzen, Gøril; Kenanova, Vania E; Daba, Muluneh B; Lauvrak, Vigdis; Buus, Søren & Sandlie, Inger (2008). Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues. The FEBS Journal.  ISSN 1742-464X.  275(16), s 4097- 4110 . doi: 10.1111/j.1742-4658.2008.06551.x Fulltekst i vitenarkiv.
  • Andersen, Jan Terje; Justesen, Sune; Berntzen, Gøril; Michaelsen, Terje Einar; Lauvrak, Vigdis; Fleckenstein, Burkhard; Buus, Søren & Sandlie, Inger (2008). A strategy for bacterial production of a soluble functional human neonatal Fc receptor. JIM - Journal of Immunological Methods.  ISSN 0022-1759.  331(1-2), s 39- 49 . doi: 10.1016/j.jim.2007.11.003 Fulltekst i vitenarkiv.
  • Qiao, Shuo Wang; Kobayashi, K; Johansen, Finn Eirik; Sollid, Ludvig Magne; Andersen, Jan Terje; Milford, E; Roopenian, DC; Lencer, WI & Blumberg, RS (2008). Dependence of antibody-mediated presentation of antigen on FcRn. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  105, s 9337- 9342 . doi: 10.1073/pnas.0801717105
  • Andersen, Jan Terje; Qian, Julie Dee & Sandlie, Inger (2006). The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin. European Journal of Immunology.  ISSN 0014-2980.  36(11), s 3044- 3051
  • Berntzen, G; Brekke, OH; Mousavi, SA; Andersen, JT; Michaelsen, Terje Einar; Berg, T; Sandlie, I & Lauvrak, V (2006). Characterization of an Fc gamma RI-binding peptide selected by phage display. Protein Engineering Design & Selection.  ISSN 1741-0126.  19(3), s 121- 128 . doi: 10.1093/protein/gzj011
  • Berntzen, Gøril; Lunde, Elin; Flobakk, Morten; Andersen, JT; Lauvrak, Vigdis; Sandlie, Inger & Andersen, Jan Terje (2005). Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells. JIM - Journal of Immunological Methods.  ISSN 0022-1759.  298

Se alle arbeider i Cristin

  • Andersen, Jan Terje & Sandlie, Inger (2011). Extending Antibody Half Lives with Albumin In: Recombinant Antibodies for Immunotherapy. Cambridge University Press.  ISBN 9780521887328.  17 s.
  • Andersen, Jan Terje & Sandlie, Inger (2011). Pharmacokinetics of IgG and albumin: The impact of FcRn for Design of Drug Delivery Systems: The impact of FcRn for Design of Drug Delivery Systems. Wiley-VCH Verlag GmbH.  ISBN 9783527328239.  34 s.
  • Andersen, Jan Terje; Sandlie, Inger; Kenanova, Vania E; Olafsen, Tove & Wu, Anna M (2010). Engineering of the Fc Region for Improved PK (FcRn interaction. Springer-Verlag Berlin Heidelberg.  ISBN 978-3-642-01143-6.  19 s.
  • Andersen, Jan Terje & Sandlie, Inger (2008). The neonatal Fc receptor controls immunoglobulin G and albumin homeostasis. Transworld Research Network.  ISBN 8178953641.  24 s.

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  • Shaw, Alan; Hoffecker, Ian T.; Smyrlaki, Ioanna; Rosa, João; Grevys, Algirdas; Bryant-Bratlie, Diane Lynn; Sandlie, Inger; Michaelsen, Terje Einar; Andersen, Jan Terje & Högberg, Björn (2019). Publisher Correction: Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies. Nature Nanotechnology.  ISSN 1748-3387.  14(4), s 398- 398 . doi: 10.1038/s41565-019-0404-3
  • Andersen, Jan Terje & Sandlie, Inger (2011). FcRn regulates the pharmacokinetics of albumin.
  • Foss, Stian; Michaelsen, Terje Einar; Sandlie, Inger & Andersen, Jan Terje (2011). The Influence of Removal of the IgG Fab Arms on Binding to FcRn. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 350- 351 . doi: 10.1111/j.1365-3083.2011.02516.x
  • Andersen, JT; Daba, Muluneh B; Berntzen, G; Michaelsen, Terje Einar & Sandlie, I (2009). Cross-species binding analyses of mouse and human neonatal Fc receptor with their ligands. Implications for evaluations of therapeutic antibodies and albumin fusions.
  • Andersen, Jan Terje & Sandlie, Inger (2007). A receptor mediated mechanism to support clinical observation of altered albumin variants. Clinical Chemistry.  ISSN 0009-9147.  53, s 2216- 2216 . doi: 10.1373/clinchem.2007.097071

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Publisert 22. jan. 2018 09:55 - Sist endret 14. juni 2019 14:48