Jørgen Valeur

• Martinsen, Tilde; Jensen, Caroline; Hatlebakk, Jan Gunnar; Valeur, Jørgen; Nygård, Ottar Kjell & Lied, Gülen Arslan (2026). Gastrointestinal symptoms, faecal short-chain fatty acids and dietary intake in older adults: the Hordaland Health Study 3. European Journal of Nutrition. ISSN 1436-6207. 65(6). doi: 10.1007/s00394-026-04077-6. Fulltekst i vitenarkiv Vis sammendrag

  Purpose: Ageing is associated with a decline in gastrointestinal (GI) functions, but data on GI symptoms in older adults remain limited. This study assessed the prevalence of GI symptoms, irritable bowel syndrome (IBS), and faecal short-chain fatty acids (SCFAs) in older adults, and associations between GI symptoms and faecal SCFAs, dietary intake, and BMI. Methods: 907 older adults (66–69 years, 50.7% females) from the community-based Hordaland Health Study 3 − Microbiota study were included. GI symptoms and IBS status were assessed by validated questionnaires (Gastrointestinal Symptom Rating Scale, Rome IV-criteria, IBS-Severity Scoring System), dietary intake by a 279-item food frequency questionnaire, and the concentration of SCFAs were measured from faecal samples. Results: 33.9% experienced at least one GI symptom, 16.4% reported IBS-like symptoms, and 5.0% had IBS according to Rome IV-criteria. Indigestion was the most common GI symptom (24.2%). Females had a higher total mean score of GI symptoms (p = 0.021), with higher frequencies of constipation (p = 0.006) and abdominal pain (p = 0.031), compared to males. Males had higher concentration of total faecal SCFAs (p = 0.004) and all major SCFAs compared to females. Total faecal SCFAs were negatively associated with constipation, independently of dietary fibre intake, total energy intake, sex and BMI (B =  − 0.006, 95% CI [− 0.009, − 0.004], p < 0.001). We observed a positive correlation between total faecal SCFA concentrations and diarrhoea (r = 0.072, p = 0.039) and looser stool consistency (r = 0.185, p < 0.001); however, these associations did not persist in the regression analyses. All GI symptoms positively correlated with increasing BMI. Conclusion: GI symptoms are common in older adults, and IBS is at least as prevalent as observed in the general adult population. Improving dietary habits and preventing overweight and obesity may reduce the risk of GI symptoms and improve gut health in older adults.

• Villmones, Heidi Cecilie & Valeur, Jørgen (2026). Persistent small intestinal microbial colonisation: a potentially pathological rather than physiological state. Medical Hypotheses. ISSN 0306-9877. 214. doi: 10.1016/j.mehy.2026.112079. Fulltekst i vitenarkiv
• Hansen, Simen Hyll; Bhattacharjee, Niharika; Hu, Chang; Maseng, Maria Gjerstad; Grannö, Olle & Bang, Corinna [Vis alle 20 forfattere av denne artikkelen] (2026). Bacterial clusters are associated with the risk of severe disease progression in inflammatory bowel disease irrespective of conventional disease categories. Microbiome Research Reports. 5(1). doi: 10.20517/mrr.2025.96. Fulltekst i vitenarkiv Vis sammendrag

  Background: Inflammatory bowel diseases (IBDs) are complex conditions marked by chronic inflammation in the gastrointestinal tract. Traditional classification separates IBD into Crohn’s disease and ulcerative colitis, but this division may not fully capture disease heterogeneity. Here, we examine whether microbiome-driven subtyping can describe novel clinical IBD phenotypes. To achieve this, we applied unsupervised clustering to fecal microbiota profiles from the population-based Inflammatory Bowel Disease in South-Eastern Norway III (IBSEN III) cohort. Methods: A Gaussian Mixture Model (GMM) was used to cluster participants with IBD based on microbiome composition and examine associations between clusters and clinical outcomes, including inflammatory markers and disease severity during the first year after inclusion. Results: Three microbiome-based clusters were identified: CLO (dominated by Clostridia UCG-014), ALF (Agathobacter, Lachnoclostridium, and Faecalibacterium), and RUM (Ruminococcus gnavus). Participants in the RUM cluster had a higher risk of future severe disease than those in the CLO cluster, even among participants with remission-to-mild disease at inclusion (21% vs. 6%, P < 0.00001). This association could not be explained by antibiotic use or baseline disease severity. Cluster membership alone performed comparably to fecal calprotectin in distinguishing severe disease, and a combined model significantly improved accuracy (P < 0.0001). Conclusion: Our findings demonstrate a connection between microbiome composition and the risk of severe disease development, which is partly independent of inflammation levels at the time of sampling. Microbiome-informed subgrouping could lead to more personalized treatment strategies. Further validation is needed to determine the clinical utility of these clusters.

• Maseng, Maria Gjerstad; Hansen, Simen Hyll; Grännö, Olle; Bang, Corinna; Lund, Charlotte & Huppertz-Hauss, Gert [Vis alle 22 forfattere av denne artikkelen] (2026). Disentangling the gut microbiome and inflammation in inflammatory bowel diseases: longitudinal observations from the IBSEN III study. Inflammatory Bowel Diseases. ISSN 1078-0998. doi: 10.1093/ibd/izag051. Fulltekst i vitenarkiv Vis sammendrag

  Background and Aim Despite the well-established involvement of the gut microbiome in inflammatory bowel disease (IBD), less is known about how the gut microbiome changes over time and how it varies with clinical disease activity and fecal calprotectin (f-calprotectin). To address this gap, we utilized samples from the population-based inception cohort of the Inflammatory Bowel Disease in South-Eastern Norway III (IBSEN III) study. Methods Data and stool samples from study participants with IBD and symptomatic controls were collected at diagnosis and after 3, 6, and 12 months. Microbiome profiling of stool samples was performed targeting the V3-V4 region of the 16S rRNA gene, and a consensus-based approach of mixed models was employed for the longitudinal microbiome analysis. Results We included 1251 samples from 744 patients with ulcerative colitis, 618 samples from 356 patients with Crohn’ s disease and 266 samples from 164 symptomatic non-IBD controls. In the IBD population, we observed that levels of f-calprotectin decreased over time, as did the patient-reported disease activity (P < .001). Distinct changes in the gut microbiome of IBD patients were observed throughout the first year, such as increased alpha diversity (P < .001) and significant taxonomic changes. Notably, there was no covariation between the changes in alpha diversity and f-calprotectin or symptom score. Conclusion The gut microbiome during the first year after IBD diagnosis showed changes that paralleled inflammation and clinical disease activity, albeit without covariation, suggesting that there may be a disease-driving impact of gut microbiome independent of inflammation and inflammation-driven symptoms.

• Dale, Hanna Fjeldheim; Kolby, Marit & Valeur, Jørgen (2025). Ultra-Processed Food Consumption and Irritable Bowel Syndrome: Current Evidence and Clinical Implications. Nutrients. 17(22), s. 3567–3567. doi: https:/www.mdpi.com/2072-6643/17/22/3567. Fulltekst i vitenarkiv Vis sammendrag

  Irritable bowel syndrome (IBS) is a prevalent disorder of gut–brain interaction (DGBI) with an adverse impact on quality of life. The global consumption of ultra-processed foods (UPF) is rapidly increasing, and UPF intake has recently been linked to a wide range of metabolic and chronic diseases. The potential role of UPF consumption in the onset and symptom generation of IBS is emerging but remains unclear. This narrative review synthesizes epidemiological evidence on the association between UPF consumption and IBS, integrates mechanistic insights from experimental and clinical studies and suggests clinical implications based on the current state of knowledge. Observational studies suggest that higher UPF intake may be associated with increased risk of IBS, although the evidence base is limited and subject to methodological challenges. Mechanistic studies indicate that additives including emulsifiers and non-nutritive sweeteners can alter pathways relevant to IBS symptom generation, such as gut microbiota composition, impair intestinal barrier function and trigger low-grade inflammation. Current evidence supports a possible link between UPF consumption and IBS. Increasing overall dietary quality and reducing UPF intake are promising complementary strategies to established dietary interventions. Future intervention trials may provide insights into relevant biological mechanisms, particularly if such changes co-occur with symptom improvement.

• Seferowicz, Maria; Lerdal, Anners; Edvardsen, Hilde Marie Erøy; Skråstad, Ragnhild Bergene; Valeur, Jørgen & Jørgenrud, Benedicte Marie [Vis alle 8 forfattere av denne artikkelen] (2025). Unveiling stages of change among medical inpatients with an increased-risk alcohol consumption—a cross-sectional study. Alcohol and Alcoholism. ISSN 0735-0414. 61(1). doi: 10.1093/alcalc/agaf067. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Aims Alcohol-related harm occurs at lower levels than previously recognized, warranting a need to identify mediators to reduce alcohol-associated risk in increased-risk drinkers. Stages of change (SOC) have been used to assess motivation for health behaviour alteration. The primary aim was to explore distribution on SOC among medical inpatients when comparing low-risk, increased-risk, and high-risk consumers as defined by Alcohol Use Disorder Identification Test-Consumption (AUDIT-C). Our secondary aim was to assess the distribution of SOC when consumption was stratified with a biomarker of alcohol use—phospatidylethanol 16:0/18:1. Methods Cross-sectional study with three participating hospitals. Recruiting consecutive medical inpatients ≥18 years with regular alcohol consumption as screened by score ≥2 on the first question in AUDIT-C (N = 888). AUDIT-C score and SOC were assessed by questionnaires, and phospatidylethanol concentration in a blood sample. Odds ratios and the 95% confidence intervals were calculated through a univariate logistic regression analysis for each variable, and multivariable logistic regression models were then fit to calculate the adjusted odds ratio and 95% confidence interval. Results Distributions of SOC differed between the three risk-groups. Distribution of SOC was comparable whether assessed by phospatidylethanol or AUDIT-C. Conclusions Increased-risk consumers constitute the majority of those in action—the only stage associated with consecutive reduction in drinking. Potentially, these results can aid in reducing perceived barriers among health care professionals in screening and offering health advice to those with increased-risk consumption and inform further research on mediators in this subgroup.

• Bekkelund, Mattis; Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Søfteland, Eirik; Dimcevski, Georg & Sangnes, Dag André (2025). Key variables associated with gastroparesis in diabetes patients with gastroparesis-like symptoms. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 60(9), s. 865–873. doi: 10.1080/00365521.2025.2531038. Fulltekst i vitenarkiv Vis sammendrag

  Background/aims Gastroparesis is a late complication of diabetes mellitus characterized by delayed gastric emptying and upper gastrointestinal symptoms. The disorder substantially impacts the quality of life, glycemic stability, nutrition and absorption of orally administered drugs. Since symptom severity is a poor predictor of gastric emptying status, the clinician has little to aid them in whom to refer for gastric emptying testing. In this study, we aim to identify clinical characteristics associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. Materials and methods Diabetes patients consecutively referred to Haukeland University Hospital for assessment of gastroparesis-like symptoms underwent gastric emptying scintigraphy, blood samples and questionnaires for assessing gastrointestinal symptoms (Gastrointestinal Symptom Rating Scale), neuroticism (Eysenck Personality Questionnaire-Short Form), and symptoms of anxiety and depression (Hospital Anxiety & Depression Scale). Results: Seventy-one patients were included in the study, of which 28 displayed delayed gastric emptying. Delayed gastric emptying was characterized by having type 1 diabetes, younger age, lower BMI, presence of other late complications including distal symmetric polyneuropathy and retinopathy, higher Hb1Ac levels and lower albumin and hemoglobin levels. Symptoms were not related to gastric emptying status. Conclusion We identified several clinical variables associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. These variables are commonly assessed during a medical consultation and may be used to aid the clinician in choosing who to refer for gastric emptying testing.

• El-Salhy, Magdhy; Valeur, Jørgen; Brønstad, Ingeborg; Gilja, Odd Helge & Hatlebakk, Jan Gunnar (2025). Possible Role of Butyric Acid in Long-Term Symptom Relief in Irritable Bowel Syndrome Patients Following Fecal Microbiota Transplantation. Neurogastroenterology and Motility. ISSN 1350-1925. 37(12). doi: 10.1111/nmo.70115. Fulltekst i vitenarkiv Vis sammendrag

  Background: We previously found that the fecal levels of short-chain fatty acids (SCFAs) changed in irritable bowel syndrome (IBS) patients at 1 month and 1 year after fecal microbiota transplantation (FMT). This study analyzed SCFAs at 2 and 3 years after FMT in the same IBS patients included in those previous studies. Methods: This study randomized 113 IBS patients into placebo, 30-g, and 60-g groups, who received FMT with 30 g of their own feces and with 30 g and 60 g of the donor's feces, respectively. The patients completed four questionnaires to assess IBS symptoms, fatigue, and quality of life, and supplied fecal samples at the baseline and at 2 and 3 years after FMT. The fecal SCFA levels were measured using gas chromatography. Results: The butyric acid level was significantly increased at 2 and 3 years after FMT in the 30-g and 60-g groups, and was significantly higher than that in the placebo group. The total SCFA and acetic acid levels decreased significantly in the 30-g and 60-g groups at 2 and 3 years after FMT, while the propionic acid level decreased in the 60-g group at both time points. The butyric acid level was inversely correlated with IBS symptoms and fatigue. Conclusion and Inferences: The increased butyric acid levels in IBS patients at 2 and 3 years after FMT and their inverse correlation with both IBS symptoms and fatigue suggest that butyric acid contributes to the long-term improvement seen after FMT (www.clinicaltrials.gov: NCT03822299).

• Olsen, Bjørn Christian Elias Grova; Opheim, Randi; Kristensen, Vendel Ailin; Høivik, Marte Lie; Lund, Charlotte & Aabrekk, Tone Bergene [Vis alle 22 forfattere av denne artikkelen] (2025). Prevalence of Irritable Bowel Syndrome Based on Rome IV Criteria in Patients in Biochemical and Endoscopic Remission From Newly Diagnosed Inflammatory Bowel Disease: One- and Three-Year Results (the IBSEN III Cohort). Inflammatory Bowel Diseases. ISSN 1078-0998. 31(10), s. 2704–2713. doi: 10.1093/ibd/izaf047. Fulltekst i vitenarkiv Vis sammendrag

  Background: Distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) flare-ups is challenging. This study used objective remission markers to accurately determine IBS prevalence in a population-based cohort of patients with IBD. Methods: Adults with ulcerative colitis and Crohn’s disease were recruited from the IBD in South-Eastern Norway III cohort study. Irritable bowel-like symptoms were assessed using the Rome IV criteria for patients in remission from IBD at 1- and 3-year follow-ups. Remission was defined objectively using the biochemical marker fecal calprotectin (FC) ≤ 250 μg/g, and comparisons to remission based on endoscopic indices were made at 1-year follow-up. Results: Among patients with FC ≤ 250 μg/g, IBS prevalences were 21.9% (n = 62/283) and 16.1% (n = 49/304) at the 1- and 3-year follow-ups, respectively, which were higher than that in the Norwegian population (9.5%; P < .005). Of patients in endoscopic remission at 1-year follow-up, 19.2% (n = 43/224) reported IBS-like symptoms, which was not significantly different from IBS prevalence for patients with FC ≤ 250 μg/g. Irritable bowel syndrome was independently associated with substantial fatigue (odds ratio: 3.05 [95% CI, 1.48-6.27]) and female sex (odds ratio: 2.67 [95% CI, 1.34-5.32]) at the 1-year follow-up. Patients with IBS reported significantly reduced health-related quality of life (HRQoL) scores. Conclusions: The prevalence of IBS among patients in remission from IBD was approximately twice as common as that in the Norwegian population. Irritable bowel syndrome was independently associated with substantial fatigue, female sex, and reduced HRQoL.

• Zerouga, Insaf; Valeur, Jørgen; Sommer, Christine; Carlsen, Monica Hauger; Hagen, Milada & Høivik, Marte Lie [Vis alle 22 forfattere av denne artikkelen] (2025). Habitual Intake of Macronutrients and Fermentable Oligo-, Di-, Monosaccharides and Polyols is not associated with Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease. Clinical Nutrition ESPEN. ISSN 2405-4577. 67, s. 105–113. doi: 10.1016/j.clnesp.2025.03.005. Fulltekst i vitenarkiv
• Strande, Vibeke; Hagen, Milada; Lund, Charlotte; Asak, Øivind Wessel; Bengtson, May-Bente & Cetinkaya, Raziye Boyar [Vis alle 26 forfattere av denne artikkelen] (2025). Predicting severe inflammatory bowel disease: a risk matrix model based on the IBSEN III inception cohort. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 60(7), s. 716–727. doi: 10.1080/00365521.2025.2512591. Fulltekst i vitenarkiv Vis sammendrag

  Background and aims: Identifying patients at risk of developing severe inflammatory bowel disease (IBD) can aid treatment decisions. However, predicting disease course remains challenging. We aimed to identify predictive factors associated with severe disease course in the first year after IBD diagnosis. Methods: Newly diagnosed adult (≥18 years) patients with IBD were recruited from a population-based inception cohort (IBSEN III study). Preselected baseline factors were tested for associations with severe disease course, defined as IBD-related hospitalisation, surgery, treatment with ≥2 steroid courses, >2 biologics and/or new event of complication (stricture, fistula, abscess only applicable Crohn's disease (CD)). From a best fitted multivariable logistic regression model stratified by diagnosis and age (18-40/>40 years), probability of severe disease for given combinations of predictive factors was summarised in prediction matrices. Results: At one-year follow-up, 90/559 (16%) patients with ulcerative colitis (UC) and 74/312 (24%) with CD had severe disease. Treatment with systemic steroids, vitamin D deficiency, Simple Clinical Colitis Activity Index >2, and hypoalbuminemia at diagnosis were all significantly associated with severe disease in UC patients. CD patients with stricturing or penetrating disease behaviour, systemic steroids and hypoalbuminemia at diagnosis were associated with severe disease course. The least favourable combination of these factors increased the probability of severe disease from 3% (95%CI[0-5%]) to 72% (95%CI[66-79%]) for UC and from 8% (95%CI[3-13%]) to 88% (95%CI[84-93%]) for CD. Conclusions: Our study identified predictive factors associated with severe disease the first year after diagnosis. The probability of severe disease summarised in matrices enables easy risk stratification.

• Lorentsen, Jing Lisa Li; Brunborg, Cathrine; Aasebø, Anders Theodor Michaelsen; Valeur, Jørgen; Haavardsholm, Espen A. & Molberg, Øyvind [Vis alle 8 forfattere av denne artikkelen] (2025). Incidence and prevalence of Behçet's disease in Oslo, Norway: a two-decade population-based analysis. Rheumatology. ISSN 1462-0324. 64(8), s. 4703–4712. doi: 10.1093/rheumatology/keaf224. Fulltekst i vitenarkiv
• Hansen, Simen Hyll; Maseng, Maria Gjerstad; Grännö, Olle; Vestergaard, Marie V; Bang, Corinna & Olsen, Bjørn Christian Elias Grova [Vis alle 33 forfattere av denne artikkelen] (2025). Fecal Microbiome Reflects Disease State and Prognosis in Inflammatory Bowel Disease in an Adult Population-Based Inception Cohort. Inflammatory Bowel Diseases. ISSN 1078-0998. 31(8), s. 2066–2080. doi: 10.1093/ibd/izaf060. Fulltekst i vitenarkiv
• Juul, Frederik Emil; Bretthauer, Michael; Johnsen, Peter Holger; Samy, Faye; Tonby, Kristian & Berdal, Jan-Erik [Vis alle 29 forfattere av denne artikkelen] (2025). Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection : A Randomized Controlled Trial. Annals of Internal Medicine. ISSN 0003-4819. 178(7), s. 940–947. doi: 10.7326/ANNALS-24-03285. Fulltekst i vitenarkiv
• Asledottir, Tora; Comi, Irene; Devold, Tove Gulbrandsen; Røseth, Arne; Valeur, Jørgen & Vegarud, Gerd (2024). Ex Vivo Digestion with Human Gastrointestinal Juices. I Ferranti, Pasquale (Red.), Proteomics applied to foods. Springer. ISSN 9781071640746. s. 149–173. doi: 10.1007/978-1-0716-4075-3_10. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). Web Exclusive. Annals Graphic Medicine - Remnants of Breaking Bad News. Annals of Internal Medicine. ISSN 0003-4819. 177(2). doi: 10.7326/G23-0006. Fulltekst i vitenarkiv
• Dale, Hanna Fjeldheim; Hagen, Milada; Malmstrøm, Gunn Helen; Fiennes, Jennifer Twisleton; Høivik, Marte Lie & Kristensen, Vendel Ailin [Vis alle 7 forfattere av denne artikkelen] (2024). Assessing hard and loose “endpoints”: comparison of patient and expert Bristol Stool Scale scoring of 2280 fecal samples. F1000 Research. 13. doi: 10.12688/f1000research.152496.2. Fulltekst i vitenarkiv Vis sammendrag

  Background Stool consistency is an important outcome measure to evaluate in the investigation of several gastrointestinal diseases. The Bristol Stool Scale (BSS) is one of the most commonly used tools for evaluation of stool consistency. BSS ranges from 1-7 and each score is assigned to a given consistency of the feces. Self-reported characterizations can differ from an expert evaluation, and the reliability of BSS is unclear. We aimed to evaluate the reliability of BSS by comparing patient scores with expert scores. Methods Patients with inflammatory bowel disease collected stool samples throughout a 3-year follow-up. The stool´s consistency was evaluated with BSS by the patients and matched with an expert score. Agreement between patient and expert scores was assessed using Cohen’s kappa. Results BSS scores from 2280 fecal samples collected from 992 patients at up to five time points were included. When all samples were compared, there was good to substantial agreement between patient and expert scores (Cohen’s weighted kappa: 0.66-0.72). When the BSS scores were simplified and categorized as 1 (scores 1-2), 2 (scores 3-5) or 3 (scores 6-7), the agreement improved slightly (Cohen’s weighted kappa: 0.73-0.77). When the scores from the first sample per patient were compared, the experts were more likely to assign higher scores compared to the patient. The proportion of the lowest assigned scores (1-2) was 12.1% for patients and 8.1% for experts. Conclusions The agreement between patient and expert BSS scores is good to substantial, especially when the BSS scores are simplified into three categories.

• Dale, Hanna Fjeldheim; Småstuen, Milada Cvancarova; Deb, Chirajyoti; Skar, Viggo Øystein & Valeur, Jørgen (2024). Diagnosing sucrase-isomaltase deficiency: a comparison of a ¹³C-sucrose breath test and a duodenal enzyme assay. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 84(4), s. 268–272. doi: 10.1080/00365513.2024.2377960. Fulltekst i vitenarkiv Vis sammendrag

  Background Reduced activity of the sucrase-isomaltase (SI) enzyme can cause gastrointestinal symptoms. Biochemical measurement of SI activity in small intestinal biopsies is presently considered the gold standard for the diagnosis of SI deficiency, but this invasive test is not suitable as a routine diagnostic tool. Aim To evaluate a 13C-sucrose-breath test (13CSBT) as a diagnostic tool for SI deficiency in an adult population. Methods 13CSBT results were compared to sucrase activity measured in duodenal biopsies. Results Forty patients with gastrointestinal symptoms were included in the study, 4 of whom had celiac disease and the rest (n = 36) had normal histological findings. Nine patients (22.5%) had low sucrase activity measured using duodenal biopsies. No correlation was observed between enzymatic sucrase activity and the 13CSBT results. The 13CSBT-curves for the celiac patients versus patients with normal duodenal histology demonstrated that the patients with celiac disease were within the lower range of the distribution. Conclusion We observed a mismatch between the 13CSBT results and the biochemically measured sucrase activity, suggesting that SI activity is not uniformly distributed throughout the small intestines. This methodological discrepancy should be acknowledged when diagnosing SI deficiency.

• Holm, Ida Marie; Lorentzen, Sissi C. Stove; Carlsen, Monica Hauger; Valeur, Jørgen; Mellin-Olsen, Tonje & Dale, Hanna Fjeldheim (2024). Evaluation of dietary quality in patients with functional gastrointestinal symptoms: a Norwegian single centre study. Food & Nutrition Research (FNR). ISSN 1654-6628. 68. doi: 10.29219/fnr.v68.10692. Fulltekst i vitenarkiv Vis sammendrag

  Background: Poor dietary quality has been described as a contributor to symptoms in subjects with functional gastrointestinal (GI) symptoms. Hitherto, the focus in dietary evaluation and treatment in this patient group has mainly been on avoiding individual nutrient deficiencies, and less attention has been given to the dietary pattern and the overall food quality. Hence, we aim to describe and evaluate the dietary quality in patients with functional GI symptoms. Methods: Patients with GI symptoms and a diagnosis of irritable bowel syndrome or inflammatory bowel disease in remission, consecutively referred to a clinical dietitian for nutritional guidance, were included. All participants completed a 7-day weighed food record. The intake of foods, energy, macro- and micronutrients was computed. Dietary quality was evaluated by intake frequencies based on a predefined food index, combined with assessing achievement of nutrient intake recommendations. Results: A total of 35 patients were included. Intake frequencies of red meat, cheese and sweets were high, whereas intake frequencies of green leafy vegetables, berries, nuts, whole grain and legumes were low. The total intake of vegetables, fruit, berries, fish and nuts was lower than current recommendations, and the intake corresponded to intake below recommendations for several micronutrients, including vitamins D, C and A; iodine; folate; potassium; and selenium. Conclusion: The group of patients with GI symptoms had overall inadequate dietary quality. Low intake of nutrient-dense food groups considered as beneficial for health corresponded with insufficient intake of several micronutrients. We recommend that dietary evaluation should focus on the intake of food groups, rather than nutrients, in the treatment of patients with functional GI symptoms, to ensure a better evaluation of dietary quality.

• Teige, Erica Sande; Hillestad, Eline Margrethe Randulff; Steinsvik, Elisabeth Kjelsvik; Brønstad, Ingeborg; Lundervold, Arvid & Lundervold, Astri J. [Vis alle 10 forfattere av denne artikkelen] (2024). Fecal bacteria and short-chain fatty acids in irritable bowel syndrome: relations to subtype. Neurogastroenterology and Motility. ISSN 1350-1925. 36(9). doi: 10.1111/nmo.14854. Fulltekst i vitenarkiv Vis sammendrag

  Background: The relationship between gut microbiota and irritable bowel syndrome (IBS) subtype is unclear. We aimed to explore whether differences in fecal bacteria composition and short-chain fatty acid (SCFA) levels were associated with subtypes and symptoms of IBS. Methods: All participants delivered fecal samples and self-reports on IBS Symptom Severity Score (IBS-SSS), Bristol Stool Scale (BSS), and Gastrointestinal Symptom Rating Scale (GSRS). Fecal bacteria composition was assessed by the GA-map® Dysbiosis Test based on 16S rRNA sequences of bacterial species/groups. SCFAs were analyzed by vacuum distillation followed by gas chromatography. Key Results: Sixty patients with IBS were included (mean age 38 years, 46 [77%] females): Twenty-one patients were classified as IBS-D (diarrhea), 31 IBS-M (mixed diarrhea and constipation), and eight IBS-C (constipation). Forty-two healthy controls (HCs) (mean age 35 years, 27 [64%] females) were included. Patients had a significantly higher relative frequency of dysbiosis, lower levels of Actinobacteria, and higher levels of Bacilli than HCs. Eight bacterial markers were significantly different across IBS subgroups and HCs, and 13 bacterial markers were weakly correlated with IBS symptoms. Clostridia and Veillonella spp. had a weak negative correlation with constipation scores (GSRS) and a weak positive correlation with loose stools (BSS). Diarrhea scores (GSRS) and looser stool (BSS) were weakly correlated with levels of total SCFAs, acetic and butyric acid. Levels of total SCFAs and acetic acid were weakly correlated with symptom severity (IBS-SSS). Conclusions & Inferences: Patients with IBS had a different fecal bacteria composition compared to HCs, and alterations of SCFAs may contribute to the subtype.

• Jensen, Caroline; Sommersten, Cathrine Horn; Laupsa-Borge, Johnny; Storås, Inghild; Valeur, Jørgen & Mellgren, Gunnar [Vis alle 9 forfattere av denne artikkelen] (2024). Quality and quantity of carbohydrates, faecal short-chain fatty acids and gastrointestinal symptoms– results from a randomised, controlled trial (CARBFUNC). Clinical Nutrition. ISSN 0261-5614. 44, s. 54–64. doi: 10.1016/j.clnu.2024.11.041. Fulltekst i vitenarkiv Vis sammendrag

  Background & aims: Diet is a key determinant of gastrointestinal (GI) health, in part in association with microbiota-derived short-chain fatty acids (SCFAs). However, we need more knowledge of the relative impact of dietary carbohydrate amount and quality on GI symptoms, GI-associated quality of life (QoL) and faecal SCFAs. Methods: 193 males and females with obesity were randomly allocated to follow one of three isocaloric, iso-proteinic dietary patterns (2000 kcal/day for females, 2500 kcal/day for males): a higher-carbohydrate lower-fat diet with refined carbohydrate sources (acellular diet, A-HCLF, comparator arm), a higher-carbohydrate lower-fat diet with minimally refined carbohydrate sources (intact cellular structures, cellular diet, C-HCLF), or a low-carbohydrate high-fat diet (LCHF), all low in added sugars. Secondary outcomes of this randomised controlled trial (CARBFUNC) were assessed, i.e., changes in abdominal symptoms (irritable bowel syndrome severity scoring system (IBS-SSS)), reflux symptoms (gastro-oesophageal reflux disease questionnaire (GerdQ)), GI-related QoL (Short-Form Nepean Dyspepsia Index (SF-NDI)) and fatigue (Fatigue Impact Scale), and faecal SCFAs concentrations after following the diets for 3 and 12 months. Group differences were analysed by constrained linear mixed effect modelling (cLMM). Results: 118 and 57 participants completed 3 and 12 months of the dietary intervention, respectively, with no significant group differences in weight loss at 12 months (5–7%). At 12 months, the mean daily fibre intake was 34 ± 7 g/day, 41 ± 14.3 g/day, and 18.5 ± 6 g/day on the A-HCLF, C-HCLF and LCHF diet, respectively, compared to 21 ± 7, 21 ± 7 and 20 ± 6 g/day at baseline. We observed no significant between-group difference in IBS-SSS sum score after 3 and 12 months. We found significant improvement in GerdQ score (change score [95 % CI]: −0.62 [−1.18, −0.048], p = 0.034), and SF-NDI sum score (−1.88 [−3.22, −0.52], p = 0.007) after 3 months on the LCHF diet compared to the A-HCLF diet, and GerdQ remained significant at 12 months (−1.03 [−1.88, −0.19], p = 0.017). Compared to the A-HCLF diet, the concentration of faecal butyric acid increased significantly more after 3 months on the C-HCLF diet (4.97 [1.71, 8.23] p = 0.003) and faecal acetic acid decreased more (−6.41 [−12.8, −0.047]. p = 0.048) on the LCHF diet. At 12 months the greater reduction in faecal acetic acid on the LCHF diet remained significant (−9.82 [−19.0, −0.67], p = 0.036), along with significantly greater reductions also in total SCFAs (−21.3 [−38.0, −4.56], p = 0.013), propionic (−4.42 [−7.79, −1.05], p = 0.010), and butyric acid (−5.05 [−9.60, −0.51], p = 0.030). Conclusion: In this sample of adults with obesity and mild GI symptoms at baseline, modest improvements were observed only for the LCHF diet in QoL (at 3 months) and reflux symptoms (at 3 and 12 months), which was significantly different from the acellular carbohydrate diet, and independent of total fibre intake. Concomitantly, compared to the acellular carbohydrate diet, the cellular diet significantly increased the faecal concentration of butyric acid, whereas the LCHF diet lowered acetic acid after 3 months and all the major SCFAs after 12 months.

• Herfindal, Anne Mari; Nilsen, Morten; Aspholm, Trude Elise; Schultz, Gry Irene Granli; Valeur, Jørgen & Rudi, Knut [Vis alle 10 forfattere av denne artikkelen] (2024). Effects of fructan and gluten on gut microbiota in individuals with self-reported non-celiac gluten/wheat sensitivity—a randomised controlled crossover trial. BMC Medicine. 22:358(1), s. 1–19. doi: 10.1186/s12916-024-03562-1. Fulltekst i vitenarkiv Vis sammendrag

  Background Individuals with non-celiac gluten/wheat sensitivity (NCGWS) experience improvement in gastrointestinal symptoms following a gluten-free diet. Although previous results have indicated that fructo-oligosaccharides (FOS), a type of short-chain fructans, were more likely to induce symptoms than gluten in self-reported NCGWS patients, the underlying mechanisms are unresolved. Methods Our main objective was therefore to investigate whether FOS-fructans and gluten affect the composition and diversity of the faecal microbiota (16S rRNA gene sequencing), faecal metabolites of microbial fermentation (short-chain fatty acids [SCFA]; gas chromatography with flame ionization detector), and a faecal biomarker of gut inflammation (neutrophil gelatinase-associated lipocalin, also known as lipocalin 2, NGAL/LCN2; ELISA). In the randomised double-blind placebo-controlled crossover study, 59 participants with self-reported NCGWS underwent three different 7-day diet challenges with gluten (5.7 g/day), FOS-fructans (2.1 g/day), and placebo separately (three periods, six challenge sequences). Results The relative abundances of certain bacterial taxa were affected differently by the diet challenges. After the FOS-fructan challenge, Fusicatenibacter increased, while Eubacterium (E.) coprostanoligenes group, Anaerotruncus, and unknown Ruminococcaceae genera decreased. The gluten challenge was primarily characterized by increased abundance of Eubacterium xylanophilum group. However, no differences were found for bacterial diversity (α-diversity), overall bacterial community structure (β-diversity), faecal metabolites (SCFA), or NGAL/LCN2. Furthermore, gastrointestinal symptoms in response to FOS-fructans were generally not linked to substantial shifts in the gut bacterial community. However, the reduction in E. coprostanoligenes group following the FOS-fructan challenge was associated with increased gastrointestinal pain. Finally, correlation analysis revealed that changes in gastrointestinal symptoms following the FOS-fructan and gluten challenges were linked to varying bacterial abundances at baseline. Conclusions In conclusion, while FOS-fructans induced more gastrointestinal symptoms than gluten in the NCGWS patients, we did not find that substantial shifts in the composition nor function of the faecal microbiota could explain these differences in the current study. However, our results indicate that individual variations in baseline bacterial composition/function may influence the gastrointestinal symptom response to both FOS-fructans and gluten. Additionally, the change in E. coprostanoligenes group, which was associated with increased symptoms, implies that attention should be given to these bacteria in future trials investigating the impact of dietary treatments on gastrointestinal symptoms. Trial registration Clinicaltrials.gov as NCT02464150.

• Dale, Hanna Fjeldheim; Hagen, Milada; Bekkelund, Mattis; Deb, Chirajyoti & Valeur, Jørgen (2024). Disaccharidase deficiencies and gastrointestinal symptoms in patients referred to gastroscopic examination: a single center study from Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 59(10), s. 1166–1171. doi: 10.1080/00365521.2024.2395848. Fulltekst i vitenarkiv Vis sammendrag

  Objective Gastrointestinal illnesses have been reported in relation to low disaccharidase activity, yet both the prevalence of disaccharidase deficiency and its association with gastrointestinal symptoms and irritable bowel syndrome (IBS) are largely unknown. We aimed to determine the association between low activity of disaccharidase enzymes on gastrointestinal symptoms and presence of IBS. Methods Patients referred for gastroscopic examination due to gastrointestinal complaints were consecutively included. A pinch biopsy was taken from the distal part of duodenum, and disaccharidase activity was measured using the Dahlqvist method. Gastrointestinal symptom severity was measured using IBS-Symptom Severity Score (IBS-SSS). Results A total of 40 patients were included. Disaccharidase deficiency was detected in 24 patients (60%). Half of the patients (n = 21) had IBS according to Rome IV criteria. A majority (75%) of all patients reported moderate to severe gastrointestinal symptoms. Moderate to severe gastrointestinal symptoms were reported by 16 patients (67%) with disaccharidase deficiency and in 14 patients (88%) with normal disaccharidase activity. Lactase deficiency was detected in 22 patients (55%), maltase deficiency in 11 patients (28%), sucrase deficiency in 9 patients (23%), isomaltase deficiency in 13 patients (33%) and glucoamylase deficiency in 12 patients (30%). The activity of all enzymes was reduced in 8 patients (20%). Degree of disaccharidase deficiency was not associated with either the severity of gastrointestinal symptoms or the diagnosis of IBS. Enzymes levels were not associated with gastrointestinal symptom scores. Conclusion Our findings did not reveal any association between biochemically measured disaccharidase deficiency and gastrointestinal symptoms or the presence of IBS.

• Zerouga, Insaf; Valeur, Jørgen; Sommer, Christine; Småstuen, Milada Cvancarova; Medhus, Asle Wilhelm & Lund, Charlotte [Vis alle 22 forfattere av denne artikkelen] (2024). Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 59(6), s. 1–9. doi: 10.1080/00365521.2024.2313056. Fulltekst i vitenarkiv Vis sammendrag

  Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim of this study was to compare dietary intakes and nutritional status in men and women with newly diagnosed IBD with a general population sample, and to investigate whether intakes were in line with the Nordic Nutrition Recommendations. Methods: This was a cross-sectional study including adults≥ 40 years with IBD from the Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III cohort study. A validated food frequency questionnaire (FFQ) was used in dietary data collection, and a sample from the seventh survey of the Tromsø Study was included as a comparison group. Results: A total of 227 men and women with IBD were included. IBD patients had higher intake of grain products, sweetened beverages, energy, fat and polyunsaturated fat (PUFA), but lower intake of dairy products, alcohol and iodine compared to adults from the comparison sample (p < 0.01). Intakes of saturated fat and carbohydrates in both genders, and vitamin D in women were not within recommended levels. Anemia and hypoalbuminemia were more prevalent in IBD patients than in the comparison sample. Conclusions: Dietary intakes in newly diagnosed IBD patients were mostly in line with Nordic Nutrition Recommendations. Higher proportion of IBD patients exceeded recommended allowances of fat and added sugar than the comparison sample. Insufficient micronutrient intake, anemia and hypoalbuminemia are present challenges in IBD patients that require monitoring.

• Birkeland, Eline; Gharagozlian, Sedeghe; Valeur, Jørgen & Aas, Anne-Marie (2023). Short-chain fatty acids as a link between diet and cardiometabolic risk: a narrative review. Lipids in Health and Disease. 22(1). doi: 10.1186/s12944-023-01803-5. Fulltekst i vitenarkiv Vis sammendrag

  Aim Diet has a profound impact on cardiometabolic health outcomes such as obesity, blood glucose, blood lipids and blood pressure. In recent years, the gut microbiota has emerged as one of several potential key players explaining dietary effects on these outcomes. In this review we aim to summarise current knowledge of interaction between diet and gut microbiota focusing on the gut-derived microbial metabolites short-chain fatty acids and their role in modulating cardiometabolic risk. Findings Many observational and interventional studies in humans have found that diets rich in fibre or supplemented with prebiotic fibres have a favourable effect on the gut microbiota composition, with increased diversity accompanied by enhancement in short-chain fatty acids and bacteria producing them. High-fat diets, particularly diets high in saturated fatty acids, have shown the opposite effect. Several recent studies indicate that the gut microbiota modulates metabolic responses to diet in, e.g., postprandial blood glucose and blood lipid levels. However, the metabolic responses to dietary interventions, seem to vary depending on individual traits such as age, sex, ethnicity, and existing gut microbiota, as well as genetics. Studies mainly in animal models and cell lines have shown possible pathways through which short-chain fatty acids may mediate these dietary effects on metabolic regulation. Human intervention studies appear to support the favourable effect of short-chain fatty acid in animal studies, but the effects may be modest and vary depending on which cofactors were taken into consideration. Conclusion This is an expanding and active field of research that in the near future is likely to broaden our understanding of the role of the gut microbiota and short-chain fatty acids in modulating metabolic responses to diet. Nevertheless, the findings so far seem to support current dietary guidelines encouraging the intake of fibre rich plant–based foods and discouraging the intake of animal foods rich in saturated fatty acids.

• Dale, Hanna Fjeldheim; Lorentzen, Sissi C. Stove; Mellin-Olsen, Tonje & Valeur, Jørgen (2023). Diet-microbiota interaction in irritable bowel syndrome: looking beyond the low-FODMAP approach. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. doi: 10.1080/00365521.2023.2228955. Fulltekst i vitenarkiv
• Stø, Kristine; Skagen, Karolina Ryeng; Valeur, Jørgen; Yang, Kuan; Bjerkeli, Vigdis & Aukrust, Pål [Vis alle 8 forfattere av denne artikkelen] (2023). Increased plasma levels of non-sugar sweeteners in patients with symptomatic carotid atherosclerosis. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 57(1). doi: 10.1080/14017431.2023.2205068. Fulltekst i vitenarkiv Vis sammendrag

  Purpose. The non-sugar sweeteners acesulfame K and saccharin are considered safe, but there is conflicting evidence on their effects on cardiovascular health. Materials and methods. In this explorative pilot study, we measured plasma levels of acesulfame K and saccharin in 15 patients with symptomatic carotid atherosclerosis, 18 asymptomatic patients and 15 control subjects. Fecal microbiota and short-chain fatty acids were analyzed. Dietary and medical history was assessed. Results. Symptomatic patients had higher levels of acesulfame K and saccharin compared to controls. Acesulfame K was associated with increased leukocyte count. Saccharin was associated with more severe carotid stenosis, as well as lower fecal butyric acid.

• Herfindal, Anne Mari; Megen, Frida van; Gilde, Mari Kristine Overvik; Valeur, Jørgen; Rudi, Knut & Skodje, Gry [Vis alle 9 forfattere av denne artikkelen] (2023). Effects of a low FODMAP diet on gut microbiota in individuals with treated celiac disease having persistent gastrointestinal symptoms-a randomized controlled trial. British Journal of Nutrition. ISSN 0007-1145. 130(12), s. 2061–2075. doi: 10.1017/S0007114523001253. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Individuals with coeliac disease (CeD) often experience gastrointestinal symptoms despite adherence to a gluten-free diet (GFD). While we recently showed that a diet low in fermentable oligo-, di-, monosaccharides and polyols (FODMAP) successfully provided symptom relief in GFD-treated CeD patients, there have been concerns that the low FODMAP diet (LFD) could adversely affect the gut microbiota. Our main objective was therefore to investigate whether the LFD affects the faecal microbiota and related variables of gut health. In a randomised controlled trial GFD-treated CeD adults, having persistent gastrointestinal symptoms, were randomised to either consume a combined LFD and GFD ( n 39) for 4 weeks or continue with GFD (controls, n 36). Compared with the control group, the LFD group displayed greater changes in the overall faecal microbiota profile (16S rRNA gene sequencing) from baseline to follow-up (within-subject β -diversity, P &lt; 0·001), characterised by lower and higher follow-up abundances (%) of genus Anaerostipes ( P group &lt; 0·001) and class Erysipelotrichia ( P group = 0·02), respectively. Compared with the control group, the LFD led to lower follow-up concentrations of faecal propionic and valeric acid (GC-FID) in participants with high concentrations at baseline ( P interaction ≤ 0·009). No differences were found in faecal bacterial α -diversity ( P group ≥ 0·20) or in faecal neutrophil gelatinase-associated lipocalin (ELISA), a biomarker of gut integrity and inflammation ( P group = 0·74), between the groups at follow-up. The modest effects of the LFD on the gut microbiota and related variables in the CeD patients of the present study are encouraging given the beneficial effects of the LFD strategy to treat functional GI symptoms (Registered at clinicaltrials.gov as NCT03678935).

• Stø, Kristine; Valeur, Jørgen; Ueland, Thor; Malmstrøm, Gunn Helen; Bjerkeli, Vigdis & Trøseid, Marius [Vis alle 12 forfattere av denne artikkelen] (2022). Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis. Scientific Reports. 12(1), s. 1–9. doi: 10.1038/s41598-022-26759-x. Fulltekst i vitenarkiv Vis sammendrag

  Abstract The short-chain fatty acid (SCFA) butyric acid maintains a healthy gut barrier and vascular endothelium. We aimed to investigate the association between fecal butyric acid, carotid atherosclerosis and risk factors for ischemic stroke. Patients with severe carotid atherosclerosis (i.e. ≥ 50% stenosis) (n = 43) were compared with healthy controls (n = 38). We analyzed fecal SCFAs by gas chromatography, microbiota composition by 16S rRNA sequencing, markers of gut barrier damage and inflammasome activation by immunoassay, and plasma SCFAs by ultra-high performance liquid chromatography-tandem mass spectroscopy. Patients had higher fecal butyric acid level ( p  = 0.024), along with increased functional potential of microbial butyric acid production ( p  = 0.031), compared with controls. Dietary fiber intake was comparable. Patients had higher levels of gut barrier damage markers CCL25 and IFABP, and the inflammasome activation marker IL-18, whereas plasma level of butyric was similar. Increased fecal butyric acid was associated with higher BMI, waist-hip ratio, HbA1c, CRP and leukocyte count. Contrary to our hypothesis, patients with severe carotid atherosclerosis had higher fecal butyric acid level, and increased microbial production, compared with controls. Gut barrier damage in patients might indicate decreased absorption of butyric acid and hence contribute to the higher fecal level.

• Soares, Jelena Zugic; Valeur, Jørgen; Benth, Jurate Saltyte; Knapskog, Anne Brita; Selbæk, Geir & Arefi, Golchin [Vis alle 10 forfattere av denne artikkelen] (2022). Vitamin D in Alzheimer's Disease: Low Levels in Cerebrospinal Fluid Despite Normal Amounts in Serum. Journal of Alzheimer's Disease. ISSN 1387-2877. 86(3), s. 1301–1314. doi: 10.3233/JAD-215536. Fulltekst i vitenarkiv Vis sammendrag

  Background:Vitamin D insufficiency has been suggested as a dementia risk factor. Objective:In this cross-sectional, explorative study we investigated whether levels of vitamin D in cerebrospinal fluid (CSF) are lower in patients with positive biomarkers of Alzheimer’s disease (AD) compared to cognitively healthy controls and whether polymorphisms of the vitamin D receptor (VDR) gene, FokI, BsmI, ApaI, and TaqI, are associated with levels of vitamin D in CSF and cognition. Methods:We included 100 patients≥65 years assessed for cognitive impairment and 76 cognitively healthy controls. Levels of 25-hydroxyvitamin D (25(OH)D) in both serum and CSF, and VDR polymorphisms were analyzed. Results:The mean level of 25(OH)D in serum was 78.6 (SD 28.9) nmol/l. While serum levels of 25(OH)D were not significantly different between the groups, CSF levels of 25(OH)D were significantly lower in patients with positive AD core biomarkers (p = 0.001) compared to patients without such biomarkers. Individuals with the BsmI major homozygote genotype had significantly lower results on a 10-word delayed recall test (p = 0.044) and verbal fluency test (p = 0.013), and individuals with the TaqI major homozygote genotype had significantly lower results on a verbal fluency test (p = 0.030) compared to individuals with the corresponding minor homozygote genotype. Conclusion:Patients with positive AD core biomarkers have low CSF levels of 25(OH)D, despite sufficient serum levels. CSF levels of 25(OH)D do not seem to be affected by any of the four VDR gene polymorphisms. TaqI and BsmI major homozygote genotypes might be at increased risk for development of cognitive decline.

• Soares, Jelena Zugic; Valeur, Jørgen; Benth, Jurate Saltyte; Knapskog, Anne Brita; Selbæk, Geir & Bogdanovic, Nenad [Vis alle 7 forfattere av denne artikkelen] (2022). Associations Between Intrathecal Levels of Vitamin D, Cytokines, and Core Biomarkers of Alzheimer's Disease: A Cross-Sectional Study. Journal of Alzheimer's Disease. ISSN 1387-2877. 89(3), s. 825–834. doi: 10.3233/JAD-220407. Fulltekst i vitenarkiv Vis sammendrag

  Background: Several studies have examined association between vitamin D levels in serum and cognition, but little is known of vitamin D levels in cerebrospinal fluid (CSF) and association with Alzheimer’s disease (AD). Objective: In this cross-sectional, explorative study we investigated possible associations of vitamin D in CSF with biomarkers for AD, amyloid-β, tau protein/phosphorylated tau protein in CSF, and with the cytokines IL-6, IL-8, and TNF-α in CSF in patients with cognitive impairment and cognitively healthy controls. Methods: We included 100 outpatients ≥65 years referred for assessment of cognitive impairment and 76 age- and sex-matched cognitively healthy controls. Levels of 25-hydroxyvitamin D (25(OH)D), amyloid-β, tau protein and phosphorylated tau protein, as well as IL-6, IL-8, and TNF-α, were analyzed in CSF in both groups. Results: Higher levels of 25(OH)D in CSF in all groups together were associated with lower levels of tau protein (p = 0.01) and phosphorylated tau protein (p = 0.005). We found no association between 25(OH)D levels in CSF and pathological levels of amyloid-β in CSF nor levels of IL-6 or TNF-α in CSF. Higher levels of 25(OH)D in CSF were associated with higher levels of IL-8 in CSF (p = 0.002). However, vitamin D explained only 6% of variance in IL-8. There was no significant difference between the patient groups and the control group regarding the association between 25(OH)D in CSF and any of the three cytokines in CSF. Conclusion: Participants with higher CSF levels of 25(OH)D exhibited reduced CSF levels of tau protein and phosphorylated tau protein.

• El-Salhy, Magdy; Casén, Christina; Valeur, Jørgen; Hausken, Trygve & Hatlebakk, Jan Gunnar (2021). Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome. World Journal of Gastroenterology (WJG). ISSN 1007-9327. 27(18), s. 2219–2237. doi: 10.3748/wjg.v27.i18.2219. Fulltekst i vitenarkiv Vis sammendrag

  BACKGROUND Faecal microbiota transplantation (FMT) seems to be a promising treatment for irritable bowel syndrome (IBS) patients. In Western countries (United States and Europe), there is a female predominance in IBS. A sex difference in the response to FMT has been reported recently in IBS patients. AIM To investigate whether there was a sex difference in the response to FMT in the IBS patients who were included in our previous randomized controlled trial of the efficacy of FMT. METHODS The study included 164 IBS patients who participated in our previous randomized controlled trial. These patients had moderate-to-severe IBS symptoms belonging to the IBS-D (diarrhoea-predominant), IBS-C (constipation-predominant) and IBS-M (mixed) subtypes, and had not responded to the National Institute for Health and Care Excellence (NICE)-modified diet. They belonged in three groups: placebo (own faeces), and active treated group (30-g or 60-g superdonor faeces). The patients completed the IBS severity scoring system (IBS-SSS), Fatigue Assessment Scale (FAS) and the IBS quality of life scale (IBS-QoL) questionnaires at the baseline and 2 wk, 1 mo and 3 mo after FMT. They also provided faecal samples at the baseline and 1 mo after FMT. The faecal bacteria profile and dysbiosis were determined using the 16S rRNA gene polymerase chain reaction DNA amplification covering V3-V9; probe labelling by single nucleotide extension and signal detection. The levels of short-chain fatty acids (SCFAs) were determined by gas chromatography and flame ionization. RESULTS There was no sex difference in the response to FMT either in the placebo group or active treated group. There was no difference between females and males in either the placebo group or actively treated groups in the total score on the IBS-SSS, FAS or IBS-QoL, in dysbiosis, or in the faecal bacteria or SCFA level. However, the response rate was significantly higher in females with diarrhoea-predominant (IBS-D) than that of males at 1 mo, and 3 mo after FMT. Moreover, IBS-SSS total score was significantly lower in female patients with IBS-D than that of male patients both 1 mo and 3 mo after FMT. CONCLUSION There was no sex difference in the response to FMT among IBS patients with moderate-to-severe symptoms who had previously not responded to NICE-modified diet. However, female patients with IBS-D respond better and have higher reduction of symptoms than males after FMT. El-Salhy M, Casen C, Valeur J, Hausken T, Hatlebakk JG. Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome. World J Gastroenterol 2021; 27(18): 2219-2237 [PMID: 34025075 DOI: 10.3748/wjg.v27.i18.2219]

• El-Salhy, Magdy; Kristoffersen, Anja Bråthen; Valeur, Jørgen; Casén, Christina; Hatlebakk, Jan Gunnar & Gilja, Odd Helge [Vis alle 7 forfattere av denne artikkelen] (2021). Long-term effects of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome. Neurogastroenterology and Motility. ISSN 1350-1925. 34(1). doi: 10.1111/nmo.14200. Fulltekst i vitenarkiv Vis sammendrag

  Background We recently found fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) patients to be an effective and safe treatment after 3 months. The present follow-up study investigated the efficacy and safety of FMT at 1 year after treatment. Methods This study included 77 of the 91 IBS patients who had responded to FMT in our previous study. Patients provided a fecal sample and completed five questionnaires to assess their symptoms and quality of life at 1 year after FMT. The dysbiosis index (DI) and fecal bacterial profile were analyzed using a 16S rRNA gene-based DNA probe hybridization. The levels of fecal short-chain fatty acids (SCFAs) were determined by gas chromatography. Results There was a persistent response to FMT at 1 year after treatment in 32 (86.5%) and 35 (87.5%) patients who received 30-g and 60-g FMT, respectively. In the 30-g FMT group, 12 (32.4%) and 8 (21.6%) patients showed complete remission at 1 year and 3 months, respectively; the corresponding numbers in the 60-g FMT group were 18 (45%) and 11 (27.5%), respectively. Abdominal symptoms and the quality of life were improved at 1 year compared with after 3 months. These findings were accompanied by comprehensive changes in the fecal bacterial profile and SCFAs. Conclusions Most of the IBS patients maintained a response at 1 year after FMT. Moreover, the improvements in symptoms and quality of life increased over time. Changes in DI, fecal bacterial profile and SCFAs were more comprehensive at 1 year than after 3 months. www.clinicaltrials.gov (NCT03822299).

• Skaarud, Kristin Aneta Joan; Hov, Johannes Espolin Roksund; Hansen, Simen Hyll; Kummen, Martin; Valeur, Jørgen & Seljeflot, Ingebjørg [Vis alle 12 forfattere av denne artikkelen] (2021). Mortality and microbial diversity after allogenic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial. Scientific Reports. 11. doi: 10.1038/s41598-021-90976-z. Fulltekst i vitenarkiv Vis sammendrag

  Gut mucosal barrier injury is common following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and associated with poor clinical outcomes. Diet is critical for microbial diversity, but whether nutritional support affects microbiota and outcome after allo-HSCT is unknown. We present a secondary analysis of a randomized controlled nutritional intervention trial during allo-HSCT. We investigated if the intervention influenced gut microbiota, short-chain fatty acids (SCFAs), and markers of gut barrier functions, and if these parameters were associated with clinical outcomes. Fecal specimens were available from 47 recipients, and subjected to 16S rRNA gene sequencing. We found no significant differences between the intervention group and controls in investigated parameters. We observed a major depletion of microbiota, SCFAs, and altered markers of gut barrier function from baseline to 3 weeks post-transplant. One-year mortality was significantly higher in patients with lower diversity at 3 weeks post-HSCT, but not related to diversity at baseline. The relative abundance of Blautia genus at 3 weeks was higher in survivors. Fecal propionic acid was associated with survival. Markers of gut barrier functions were less strongly associated with clinical outcomes. Possibly, other strategies than dietary intervention are needed to prevent negative effects of gut microbiota and clinical outcomes after allo-HSCT.

• Farup, Per Grønaas & Valeur, Jørgen (2020). Changes in Faecal Short-Chain Fatty Acids after Weight-Loss Interventions in Subjects with Morbid Obesity. Nutrients. 12(3). doi: 10.3390/nu12030802. Fulltekst i vitenarkiv Vis sammendrag

  The gut microbiota and their metabolites, e.g., short-chain fatty acids (SCFA), are associated with obesity. The primary aims were to study faecal SCFA levels and the changes in SCFA levels after weight-loss interventions in subjects with obesity, and secondarily, to study factors associated with the faecal SCFA levels. In total, 90 subjects (men / women: 15/75) with a mean age of 44.4 (SD 8.4) years, BMI 41.7 (SD 3.7) kg/m2 and morbid obesity (BMI > 40 or > 35 kg/m2 with obesity-related complications) were included. Faecal SCFA and other variables were measured at inclusion and after a six-month conservative weight-loss intervention followed by bariatric surgery (Roux-en-Y gastric bypass or gastric sleeve). Six months after surgery, the total amount of SCFA was reduced, the total and relative amounts of the main straight SCFA (acetic-, propionic-, and butyric- acids) were reduced, and the total and relative amounts of branched SCFA (isobutyric-, isovaleric-, and isocaproic- acids) were increased. The changes indicate a shift toward a proteolytic fermentation pattern with unfavorable health effects. The amount of SCFA was associated with the diet but not with metabolic markers or makers of the faecal microbiota composition. Dietary interventions could counteract the unfavorable effects. View Full-Text Keywords: obesity; short-chain fatty acids; bariatric surgery; weight-loss; faecal microbiota

• El-Salhy, Magdy; Valeur, Jørgen; Hausken, Trygve & Hatlebakk, Jan Gunnar (2020). Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome. Neurogastroenterology and Motility. ISSN 1350-1925. 33(2). doi: 10.1111/nmo.13983. Fulltekst i vitenarkiv Vis sammendrag

  Background Short‐chain fatty acids (SCFAs) may play a role in the pathophysiology of irritable bowel syndrome (IBS). This study analyzed fecal SCFAs after performing fecal microbiota transplantation (FMT) in the IBS patients who were included in our previous study of the efficacy of FMT. Methods This study included 142 of the 164 IBS patients who participated in our previous study. They were belonging to three groups: placebo (own feces), 30‐g (superdonor feces), and 60‐g (superdonor feces) FMT. The patients completed the IBS Severity Scoring System (IBS‐SSS) Birmingham IBS Symptom, Fatigue Assessment Scale (FAS), the IBS Quality of Life (IBS‐QoL) and Short‐Form Nepean Dyspepsia Index (SF‐NDI) questionnaires and delivered fecal samples at the baseline and 1 month after FMT. The SCFA levels were determined by vacuum distillation followed by gas chromatography. Key Results The fecal butyric acid level was significantly increased after FMT in both the 30‐g and 60‐g groups (both P ≤ 0.001). In the 60‐g group, the levels of total SCFAs and isobutyric, isovaleric, and valeric acids increased after FMT. Butyric acid levels in the responders in both the 30‐g and 60‐g FMT groups were significantly inversely correlated with IBS‐SSS and FAS scores (P = 0.001, r = −0.3 and P = 0.0001. r=‐ 0.3, respectively). There were no differences in the SCFA levels in the placebo group after FMT. Conclusion and Inferences FMT increases the fecal SCFA levels in IBS patients. The increase in the butyric acid level is inversely correlated with symptoms in IBS patients following FMT, suggesting that SCFAs might play a role in the pathophysiology of IBS. www.clini​caltr​ials.gov (NCT03822299).

• Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Hausken, Trygve & Gilja, Odd Helge (2020). Postprandial symptoms in patients with functional dyspepsia and irritable bowel syndrome: relations to ultrasound measurements and psychological factors. Journal of Neurogastroenterology and Motility. ISSN 2093-0879. 26(1), s. 96–105. doi: 10.5056/jnm19072. Fulltekst i vitenarkiv Vis sammendrag

  Background/Aims Dyspeptic symptoms are common in patients with functional gastrointestinal (GI) disorders, and may be related to visceral hypersensitivity. We aim to explore the relation between visceral hypersensitivity by using an ultrasonographic meal test and questionnaires in patients with irritable bowel syndrome (IBS) and/or functional dyspepsia (FD). Methods Patients (FD, n = 94; IBS, n = 88; IBS + FD, n = 66, healthy controls [HC], n = 30) were recruited consecutively and examined with ultrasound of the proximal and distal stomach after drinking 500 mL of a low caloric meat soup, and scored dyspeptic symptoms on a visual analogue scale (0–100 mm) before and after the meal. Psychological symptoms were assessed by Visceral Sensitivity Index (GI specific anxiety, n = 58), and Eysenck’s Personality Questionnaire-neuroticism (EPQ-N, n = 203). Results Patients with IBS and/or FD reported higher levels of nausea, upper GI discomfort, and epigastric pain both before and after a liquid meal compared to HC (P < 0.001), and had a larger antral area in a fasting state, compared to HC. We found impaired accommodation in 33% of the patients with FD, however ultrasound measurements and symptom severity did not correlate. Symptoms of epigastric pain, fullness and upper GI discomfort positively correlated to Visceral Sensitivity Index and EPQ-N in a fasting state, but not postprandially. Conclusions Nausea, upper GI discomfort, and epigastric pain was common in patients with IBS and FD. Both patient groups had enlarged antral area in a fasting state compared to HC. Discomfort and pain were associated to GI specific anxiety and neuroticism in a fasting state

• Fretheim, Håvard Halland; Chung, Brian K.; Didriksen, Henriette; Bækkevold, Espen Sønderaal; Midtvedt, Øyvind & Brunborg, Cathrine [Vis alle 18 forfattere av denne artikkelen] (2020). Fecal Microbiota Transplantation in Systemic Sclerosis: A Double-Blind, Placebo-Controlled Randomized Pilot Trial. PLOS ONE. 15:e0232739(5), s. 1–14. doi: 10.1371/journal.pone.0232739. Fulltekst i vitenarkiv Vis sammendrag

  Objectives Systemic sclerosis (SSc) is an auto-immune, multi organ disease marked by severe gastrointestinal (GI) involvement and gut dysbiosis. Here, we aimed to determine the safety and efficacy of fecal microbiota transplantation (FMT) using commercially-available anaerobic cultivated human intestinal microbiota (ACHIM) in SSc. Methods Ten patients with SSc were randomized to ACHIM (n = 5) or placebo (n = 5) in a double-blind, placebo-controlled 16-week pilot. All patients had mild to severe upper and lower GI symptoms including diarrhea, distention/bloating and/or fecal incontinence at baseline. Gastroduodenoscopy transfer of ACHIM or placebo was performed at weeks 0 and 2. Primary endpoints were safety and clinical efficacy on GI symptoms assessed at weeks 4 and 16. Secondary endpoints included changes in relative abundance of total, immunoglobulin (Ig) A- and IgM-coated fecal bacteria measured by 16s rRNA sequencing. Results ACHIM side effects were mild and transient. Two placebo controls experienced procedure-related serious adverse events; one developed laryngospasms at week 0 gastroduodenoscopy necessitating study exclusion whilst one encountered duodenal perforation during gastroduodenoscopy at the last study visit (week 16). Decreased bloating, diarrhea and/or fecal incontinence was observed in four of five patients in the FMT group (week 4 or/and 16) and in two of four in the placebo group (week 4 or 16). Relative abundance, richness and diversity of total and IgA-coated and IgM-coated bacteria fluctuated more after FMT, than after placebo. Conclusions FMT of commercially-available ACHIM is associated with gastroduodenoscopy complications but reduces lower GI symptoms by possibly altering the gut microbiota in patients with SSc.

• Birkeland, Eline; Gharagozlian, Sedegheh; Birkeland, Kåre I.; Valeur, Jørgen; Måge, Ingrid & Rud, Ida [Vis alle 7 forfattere av denne artikkelen] (2020). Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial. European Journal of Nutrition. ISSN 1436-6207. 59, s. 3325–3338. doi: 10.1007/s00394-020-02282-5. Fulltekst i vitenarkiv Vis sammendrag

  Purpose Compared to a healthy population, the gut microbiota in type 2 diabetes presents with several unfavourable features that may impair glucose regulation. The aim of this study was to evaluate the prebiotic efect of inulin-type fructans on the faecal microbiota and short-chain fatty acids (SCFA) in patients with type 2 diabetes. Methods The study was a placebo controlled crossover study, where 25 patients (15 men) aged 41–71 years consumed 16 g of inulin-type fructans (a mixture of oligofructose and inulin) and 16-g placebo (maltodextrin) for 6 weeks in randomised order. A 4-week washout separated the 6 weeks treatments. The faecal microbiota was analysed by high-throughput 16S rRNA amplicon sequencing and SCFA in faeces were analysed using vacuum distillation followed by gas chromatography. Results Treatment with inulin-type fructans induced moderate changes in the faecal microbiota composition (1.5%, p=0.045). A bifdogenic efect was most prominent, with highest positive efect on operational taxonomic units (OTUs) of Bifdobacterium adolescentis, followed by OTUs of Bacteroides. Signifcantly higher faecal concentrations of total SCFA, acetic acid and propionic acid were detected after prebiotic consumption compared to placebo. The prebiotic fbre had no efects on the concentration of butyric acid or on the overall microbial diversity. Conclusion Six weeks supplementation with inulin-type fructans had a signifcant bifdogenic efect and induced increased concentrations of faecal SCFA, without changing faecal microbial diversity. Our fndings suggest a moderate potential of inulin-type fructans to improve gut microbiota composition and to increase microbial fermentation in type 2 diabetes. Trial registration The trial is registered at clinicaltrials.gov (NCT02569684).

• Berentsen, Birgitte; Nagaraja, Bharath Halandur; Teige, Erica Persson; Lied, Gülen Arslan; Lundervold, Astri & Lundervold, Katarina [Vis alle 21 forfattere av denne artikkelen] (2020). Study protocol of the Bergen brain-gut-microbiota-axis study: A prospective case-report characterization and dietary intervention study to evaluate the effects of microbiota alterations on cognition and anatomical and functional brain connectivity in patients with irritable bowel syndrome. Medicine. ISSN 0025-7974. 99:e21950(37), s. 1–8. doi: 10.1097/MD.0000000000021950. Fulltekst i vitenarkiv Vis sammendrag

  Introduction: Irritable bowel syndrome (IBS) is a common clinical label for medically unexplained gastrointestinal (GI) symptoms, recently described as a disturbance of the brain-gut-microbiota (BGM) axis. To gain a better understanding of the mechanisms underlying the poorly understood etiology of IBS, we have designed a multifaceted study that aim to stratify the complex interaction and dysfunction between the brain, the gut, and the microbiota in patients with IBS. Methods: Deep phenotyping data from patients with IBS (n = 100) and healthy age- (between 18 and 65) and gender-matched controls (n = 40) will be collected between May 2019 and December 2021. Psychometric tests, questionnaires, human biological tissue/samples (blood, faeces, saliva, and GI biopsies from antrum, duodenum, and sigmoid colon), assessment of gastric accommodation and emptying using transabdominal ultrasound, vagal activity, and functional and structural magnetic resonance imaging (MRI) of the brain, are included in the investigation of each participant. A subgroup of 60 patients with IBS-D will be further included in a 12-week low FODMAP dietary intervention-study to determine short and long-term effects of diet on GI symptoms, microbiota composition and functions, molecular GI signatures, cognitive, emotional and social functions, and structural and functional brain signatures. Deep machine learning, prediction tools, and big data analyses will be used for multivariate analyses allowing disease stratification and diagnostic biomarker detection. Discussion: To our knowledge, this is the first study to employ unsupervised machine learning techniques and incorporate systems-based interactions between the central and the peripheral components of the brain-gut-microbiota axis at the levels of the multiomics, microbiota profiles, and brain connectome of a cohort of 100 patients with IBS and matched controls; study long-term safety and efficacy of the low-FODMAP diet on changes in nutritional status, gut microbiota composition, and metabolites; and to investigate changes in the brain and gut connectome after 12 weeks strict low-FODMAP-diet in patients with IBS. However, there are also limitations to the study. As a restrictive diet, the low-FODMAP diet carries risks of nutritional inadequacy and may foster disordered eating patterns. Strict FODMAP restriction induces a potentially unfavourable gut microbiota, although the health effects are unknown.

• Kristensen, Vendel Ailin; Valeur, Jørgen; Brackmann, Stephan; Jahnsen, Jørgen; Brunborg, Cathrine & Tveito, Kari (2019). Attention deficit and hyperactivity disorder symptoms respond to gluten-free diet in patients with coeliac disease. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(5), s. 571–576. doi: 10.1080/00365521.2019.1608467. Fulltekst i vitenarkiv
• Mazzawi, Tarek; Hausken, Trygve; Hov, Johannes Espolin Roksund; Valeur, Jørgen; Sangnes, Dag André & El-Salhy, Magdy [Vis alle 9 forfattere av denne artikkelen] (2019). Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(6), s. 690–699. doi: 10.1080/00365521.2019.1624815. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: Irritable bowel syndrome (IBS) may be associated with disturbances in gut microbiota composition and functions. We recently performed a study of fecal microbiota transplantation (FMT) in diarrhea-predominant IBS (IBS-D) and found that IBS symptoms improved and the gut microbiota profile changed following FMT. We now aimed to explore the effects of FMT on the gut microenvironment in further detail by using 16S rRNA sequencing for more extended microbiota profiling and analyzing bacterial fermentation products (SCFAs: short chain fatty acids). Materials and methods: The study included 13 patients (four females and nine males) with IBS-D according to Rome III criteria and 13 healthy donors. Freshly donated feces were administered into duodenum via gastroscopy. The patients completed symptom and quality of life (QoL) questionnaires and delivered feces before and 1, 3, 12 and 20/28 weeks after FMT. Microbiota analysis was performed by sequencing 16S rRNA gene with Illumina Miseq technology. Fecal concentrations of SCFAs were analyzed by vacuum distillation followed by gas chromatography. Results: Several gut microbiota taxa and SCFAs were significantly different in the patients at baseline compared to their donors. These differences normalized by the third week following FMT in parallel with significant improvement in symptoms and QoL. Responders had different gut microbiota profile and SCFAs than nonresponders. Significant correlations were found between the gut microenvironment and IBS symptoms. No adverse effects were reported. Conclusions: FMT restores alterations of the gut microenvironment in IBS-D patients during the first 3 weeks and improves their symptoms for up to 28 weeks.

• Dale, Hanna Fjeldheim; Jensen, Caroline; Hausken, Trygve; Hatlebakk, Jan Gunnar; Brønstad, Ingeborg & Valeur, Jørgen [Vis alle 8 forfattere av denne artikkelen] (2019). Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome. Nutrients. 11:1635(7), s. 1–13. doi: 10.3390/nu11071635. Fulltekst i vitenarkiv Vis sammendrag

  Peptides from fish may beneficially affect several metabolic outcomes, including gut health and inflammation. The effect of fish peptides in subjects with irritable bowel syndrome (IBS) has not previously been investigated, hence this study aimed to evaluate the effect of a cod protein hydrolysate (CPH) supplement on symptom severity, gut integrity markers and fecal fermentation in IBS-patients. A double-blind, randomized parallel-intervention with six weeks of supplementation with 2.5 g CPH (n = 13) or placebo (n = 15) was conducted. The outcomes were evaluated at baseline and the end of the study. The primary outcomes were symptom severity evaluated by the IBS severity scoring system (IBS-SSS) and quality of life. The secondary outcomes included gut integrity markers and pro-inflammatory cytokines in serum, fecal fermentation measured by concentration of short-chain fatty acids (SCFAs) and fecal calprotectin. The groups were comparable at baseline. The total IBS-SSS-scores were reduced in both the CPH-group (298 ± 69 to 236 ± 106, p = 0.081) and the placebo-group (295 ± 107 to 202 ± 103, p = 0.005), but the end of study-scores did not differ (p = 0.395). The concentrations of serum markers and SCFAs did not change for any of the groups. The baseline measures for the whole group showed that the total SCFA concentrations were inversely correlated with the total IBS-SSS-score (r = −0.527, p = 0.004). Our study showed that a low dose of CPH taken daily by IBS-patients for six weeks did not affect symptom severity, gut integrity markers or fecal fermentation when compared to the placebo group.

• Bjørkhaug, Steinar Traae; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Aanes, Håvard; Skar, Viggo Øystein & Medhus, Asle Wilhelm [Vis alle 7 forfattere av denne artikkelen] (2019). Plasma cytokine levels in patients with chronic alcohol overconsumption: relations to gut microbiota markers and clinical correlates. Alcohol. ISSN 0741-8329. 85, s. 35–40. doi: 10.1016/j.alcohol.2019.10.002. Fulltekst i vitenarkiv Vis sammendrag

  BACKGROUND: Alcohol-related morbidity may involve changes in the gut microbiota and immune dysregulation. We have previously demonstrated alterations in gut microbiota composition and functions in patients with alcohol overconsumption, and now aimed to investigate possible associations between cytokine levels, gut microbiota and clinical symptoms. METHODS: We included hospital inpatients with a history of chronic alcohol overconsumption. For comparison, we included control patients with a low alcohol intake. Cytokine levels (TGF-β1, TNF-α, IL-10, IL-8, IL-6, IFN-γ, MCP-1, IL-1RA, IL-1β and IL-17) were determined using a customized V-plex assay. We then examined associations of cytokine levels with the abundance of Proteobacteria and Faecalibacterium, percentage of the short-chain fatty acid butyrate, psychiatric symptoms (Hospital Anxiety and Depression Scale) and biochemical liver variables. RESULTS: We included 28 patients with alcohol overconsumption (79% men), and 25 control patients (72% men). Patients with alcohol overconsumption had higher levels of IL-6 (p = 0.002), IFN-γ (p = 0.018) and MCP-1 (p = 0.006), and lower levels of TGF-β1 (p = 0.017) compared with control patients. Inverse correlations were found between Proteobacteria abundance and TNF-α (Rs = -0.55, p = 0.02) and IL-8 (Rs = -0.58, p = 0.014), and between Faecalibacterium and MCP-1 levels (Rs = -0.56, p = 0.02) in the control patients, but not in patients with alcohol overconsumption. Patients with alcohol overconsumption reported more psychiatric symptoms, and these symptoms were inversely correlated with IL-10 levels. There were positive correlations between several of the assessed cytokines and biochemical liver variables, and negative correlations between cytokine levels and albumin. CONCLUSION: Patients with alcohol overconsumption had a cytokine profile suggestive of increased systemic inflammatory activity, with higher levels of pro-inflammatory cytokines (IL-6, IFN-γ and MCP-1) and lower levels of anti-inflammatory cytokines (TGF-β1). The findings may represent a link between alcohol use and alcohol-related morbidity. Copyright © 2019 Elsevier Inc. All rights reserved. KEYWORDS: HADS; alcoholism; immune system; inflammation

• Bjørkhaug, Steinar Traae; Aanes, Håvard; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Malvik, Stine & Henriksen, Christine [Vis alle 9 forfattere av denne artikkelen] (2019). Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption. Gut microbes. ISSN 1949-0976. 10(6), s. 663–675. doi: 10.1080/19490976.2019.1580097. Fulltekst i vitenarkiv Vis sammendrag

  Excessive alcohol intake can alter the gut microbiota, which may underlie the pathophysiology of alcohol-related diseases. We examined gut microbiota composition and functions in patients with alcohol overconsumption for >10 years, compared to a control group of patients with a history of no or low alcohol intake. Faecal microbiota composition was assessed by 16S rRNA sequencing. Gut microbiota functions were evaluated by quantification of short-chain fatty acids (SCFAs) and predictive metagenome profiling (PICRUSt). Twenty-four patients, mean age 64.8 years (19 males), with alcohol overconsumption, and 18 control patients, mean age 58.2 years (14 males) were included. The two groups were comparable regarding basic clinical variables. Nutritional assessment revealed lower total score on the screening tool Mini Nutritional Assessment, lower muscle mass as assessed by handgrip strength, and lower plasma vitamin C levels in the alcohol overconsumption group. Bacteria from phylum Proteobacteria were found in higher relative abundance, while bacteria from genus Faecalibacterium were found in lower relative abundance in the group of alcohol overconsumers. The group also had higher levels of the genera Sutterella, Holdemania and Clostridium, and lower concentration and percentage of butyric acid. When applying PICRUSt to predict the metagenomic composition, we found that genes related to invasion of epithelial cells were more common in the group of alcohol overconsumers. We conclude that gut microbiota composition and functions in patients with alcohol overconsumption differ from patients with low consumption of alcohol, and seem to be skewed into a putative pro-inflammatory direction.

• Farup, Per Grønaas; Lydersen, Stian & Valeur, Jørgen (2019). Are Nonnutritive Sweeteners Obesogenic? Associations between Diet, Faecal Microbiota, and Short-Chain Fatty Acids in Morbidly Obese Subjects. Journal of Obesity. ISSN 2090-0708. 2019, s. 1–8. doi: 10.1155/2019/4608315. Fulltekst i vitenarkiv Vis sammendrag

  Obesity has been associated with changes in the gut microbiota and its metabolites. The study explored changes in the faecal microbiota and short-chain fatty acids (SCFA) associated with the diet (including nonnutritive sweeteners (NNSs)) and evaluated metabolic consequences in subjects with morbid obesity. The diet was assessed with a validated food frequency questionnaire. One unit of NNSs was 100 mL beverage with NNSs or 2 tablets/teaspoons of NNSs. The faecal microbiota was assessed with GA-map® dysbiosis test and SCFA with gas chromatography and flame ionisation detection. Fourteen men and 75 women with a mean age of 44.6 (SD 8.7) years, BMI 41.8 (SD 3.6) kg/m2, and intake of NNSs 7.5 units/day (SD 3.2; range 0-43) were included. Faecal butyric acid was positively and negatively associated with the intake of starch (partial correlation = 0.264; p=0.015) and NNSs (partial correlation = -0.274; p=0.011), respectively. NNSs were associated with changes in four out of 39 bacterial groups. Butyric acid has antiobesogenic effects, reduces insulin resistance, and improves dyslipidaemia. Since the weight-reducing effect of NNSs on obese adults trying to lose weight is dubious, it seems imprudent to use NNSs that might counteract the favourable effects of butyric acid.

• Farup, Per Grønaas; Aasbrenn, Martin & Valeur, Jørgen (2018). Separating “good” from “bad” faecal dysbiosis – evidence from two cross-sectional studies. BMC Obesity. 5(30), s. 1–10. doi: 10.1186/s40608-018-0207-3. Fulltekst i vitenarkiv Vis sammendrag

  Background Faecal dysbiosis associated with the use of metformin has been conceived as a favourable (“good”) dysbiosis and that with intake of non-nutritive sweeteners (NNS) as unfavourable (“bad”). The study aimed to construct an alternative dysbiosis index (ADI) for the separation of the dysbioses into “good” and “bad”, and to validate the ADI. Methods Subjects with morbid obesity were included. Use of NNS and drugs were noted, IBS was classified according to the Rome III criteria and the severity measured with the Irritable bowel severity scoring system (IBSSS). Faecal dysbiosis was tested with GA-Map ™ Dysbiosis test (Genetic Analysis AS, Oslo, Norway). The result was given as Dysbiosis Index (DI) scores 1–5, score > 2 indicates dysbiosis. An ADI was constructed and validated in subjects with IBS at another hospital. Results Seventy-six women and 14 men aged 44.7 years (SD 8.6) with BMI 41.8 kg/m2 (SD 3.6) were included. Dysbiosis was associated with the use of NNS and metformin, but not with IBS or IBSSS. An ADI based on differences in 7 bacteria was positively and negatively associated with the “good” metformin dysbiosis and the “bad” NNS dysbiosis respectively. The ADI was also negatively associated with IBSSS (a “bad” dysbiosis). The negative associations between ADI and IBS and IBSS were confirmed in the validation group. Conclusions The new ADI, but not the DI, allowed separation of the “good” and “bad” faecal dysbiosis. Rather than merely reporting dysbiosis and degrees of dysbiosis, future diagnostic tests should distinguish between types of dysbiosis.

• Ramsli, Tone Maren; Valeur, Jørgen; Pretorius, Mikkel & Gerlyng, Per (2018). Severe, reversible dysphagia and malnutrition in a patient with tumour-induced hypophosphataemia. BMJ Case Reports. doi: 10.1136/bcr-2017-223873. Fulltekst i vitenarkiv
• Bøgseth, Arnhild Østerås; Soares, Jelena Zugic; Undseth, Ragnhild Marie & Valeur, Jørgen (2018). Okklusjon av Percherons arterie. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 138(19), s. 1854–1854. doi: 10.4045/tidsskr.18.0298. Fulltekst i vitenarkiv
• Dahl, Cecilie; Stigum, Hein; Valeur, Jørgen; Iszatt, Nina; Lenters, Virissa Claire & Peddada, Shyamal [Vis alle 10 forfattere av denne artikkelen] (2018). Preterm infants have distinct microbiomes not explained by mode of delivery, breastfeeding duration or antibiotic exposure. International Journal of Epidemiology. ISSN 0300-5771. 47(5), s. 1658–1669. doi: 10.1093/ije/dyy064. Fulltekst i vitenarkiv
• Juul, Frederik Emil; Garborg, Kjetil Kjeldstad; Bretthauer, Michael; Skudal, Hilde Kristin; Oines, Mari N. & Wiig, Håvard [Vis alle 16 forfattere av denne artikkelen] (2018). Fecal microbiota transplantation for primary Clostridium difficile infection. New England Journal of Medicine. ISSN 0028-4793. 378(26), s. 2535–2537. doi: 10.1056/NEJMc1803103. Fulltekst i vitenarkiv
• Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian & Kummen, Martin [Vis alle 17 forfattere av denne artikkelen] (2018). Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction. Scientific Reports. 8. doi: 10.1038/s41598-018-25168-3. Fulltekst i vitenarkiv Vis sammendrag

  HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition and related metabolites, and a potential relation to endothelial dysfunction in individuals with HIV-infection only (n = 23), diabetes only (n = 16) or both conditions (n = 21), as well as controls (n = 24). Fecal microbiota was analyzed by Illumina sequencing of the 16 S rRNA gene. Markers of endothelial dysfunction (asymmetric dimethylarginine [ADMA]), tryptophan catabolism (kynurenine/tryptophan [KT]-ratio), and inflammation (neopterin) were measured by liquid chromatography-tandem mass spectrometry. The combination of HIV and type 2 diabetes was associated with reduced gut microbiota diversity, increased plasma KT-ratio and neopterin. Microbial genes related to tryptophan metabolism correlated with KT-ratio and low alpha diversity, in particular in HIV-infected with T2D. In multivariate analyses, KT-ratio associated with ADMA (β = 4.58 [95% CI 2.53–6.63], p < 0.001), whereas microbiota composition per se was not associated with endothelial dysfunction. Our results indicate that tryptophan catabolism may be related to endothelial dysfunction, with a potentially detrimental interaction between HIV and diabetes. The potential contribution of gut microbiota and the impact for cardiovascular risk should be further explored in prospective studies powered for clinical end points.

• Aasbrenn, Martin; Valeur, Jørgen & Farup, Per Grønaas (2018). Evaluation of a faecal dysbiosis test for irritable bowel syndrome in subjects with and without obesity. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 78(1-2), s. 109–113. doi: 10.1080/00365513.2017.1419372. Fulltekst i vitenarkiv
• Farup, Per Grønaas & Valeur, Jørgen (2018). Faecal microbial markers and psychobiological disorders in subjects with morbid obesity. A cross-sectional study. Behavioral Sciences. 8(10). doi: 10.3390/bs8100089. Fulltekst i vitenarkiv Vis sammendrag

  Morbidly obese subjects have a high prevalence of comorbidity and gut microbial dysbiosis, and are thus suitable for the study of gut-brain interactions. The aim was to study the associations between the faecal microbiota’s composition and function and psychobiological comorbidity in subjects with BMI > 40 kg/m2 or >35 kg/m2 with obesity-related complications. The faecal microbiota was assessed with GA-Map dysbiosis test ™ (Genetic Analysis, Oslo Norway) and reported as dysbiosis (yes/no) and degree of dysbiosis, and the relative abundance of 39 bacteria. The microbiota’s function was assessed by measuring the absolute and relative amount of faecal short chain fatty acids. Associations were made with well-being, mental distress, fatigue, food intolerance, musculoskeletal pain, irritable bowel syndrome, and degree of abdominal complaints. One hundred and two subjects were included. The results confirmed the high prevalence of comorbidity and dysbiosis (62/102; 61%) and showed a high prevalence of significant associations (41/427; 10%) between the microbiota’s composition and function and the psychobiological disorders. The abundant, but in part divergent, associations supported the close gut-brain interaction but revealed no clear-cut and straightforward communication pathways. On the contrary, the study illustrates the complexity of gut-brain interactions.

• Valeur, Jørgen; Småstuen, Milada C; Knudsen, Torunn; Lied, Gülen Arslan & Røseth, Arne (2018). Exploring gut microbiota composition as an indicator of clinical response to dietary FODMAP restriction in patients with irritable bowel syndrome. Digestive Diseases and Sciences. ISSN 0163-2116. 63(2), s. 429–436. doi: 10.1007/s10620-017-4893-3. Fulltekst i vitenarkiv
• Landfald, Bjarne; Valeur, Jørgen; Berstad, Arnold & Raa, Jan (2017). Microbial trimethylamine-N-oxide as a disease marker: something fishy? Microbial Ecology in Health and Disease. ISSN 0891-060X. 28(1). doi: 10.1080/16512235.2017.1327309. Fulltekst i vitenarkiv Vis sammendrag

  Production of trimethylamine-N-oxide (TMAO) via the gut microbiota has recently been proposed as an important pathophysiological mechanism linking ingestion of ‘unhealthy foods’, such as beef (containing carnitine) and eggs (containing choline), and the development of atherosclerosis. Hence, TMAO has gained attention as a novel biomarker for cardiovascular disease. However, fish and seafood contain considerable amounts of TMAO and are generally accepted as cardioprotective: a puzzling paradox that seems to have been neglected. We suspect that the TMAO story may be a red herring.

• Lillestøl, Kristine & Valeur, Jørgen (2017). Johan Karl Unger Vetlesen – Noregs fyrste gastroenterolog. Michael. ISSN 1893-9651. 14(3), s. 217–230. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Tollisen, Anita; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Chronic alcohol overconsumption may alter gut microbial metabolism: a retrospective study of 719 13C-D-xylose breath test results. Microbial Ecology in Health and Disease. ISSN 0891-060X. 28(1). doi: 10.1080/16512235.2017.1301725. Fulltekst i vitenarkiv Vis sammendrag

  Objective: Alterations of gut microbiota composition or function may participate in the pathophysiology of several diseases. We aimed to explore the effect of chronic alcohol overconsumption on gut microbial metabolism, as assessed by evaluating 13C-D-xylose breath test results. Materials and methods: We investigated all 13C-D-xylose breath tests performed at Lovisenberg Diaconal Hospital during the years 2005 to 2011, using patient files for diagnosing the patients into one of three patient categories: alcohol overconsumption, coeliac disease and functional bowel disorder. In addition, a group of healthy controls was included. The time curves of 13CO2 excretion in breath samples were divided into two phases, evaluating small intestinal absorption (0–60 min) and colonic microbial metabolism (90–240 min), respectively. Results: A total of 719 patients underwent 13C-D-xylose breath testing during the inclusion period. Thirty-five had a history of alcohol overconsumption, 66 had coeliac disease, and 216 had a functional bowel disorder, while 44 healthy controls were included for comparison. The alcohol overconsumption group had similar small intestinal phase results as the group of patients with untreated coeliac disease. During the colonic phase, the group of patients with alcohol overconsumption differed from all the other groups in terms of 13C-xylose recovery, with significantly less 13CO2 excretion compared to the other groups. Conclusion: The results suggest that patients with a history of alcohol overconsumption suffer from both small intestinal malabsorption and impaired colonic microbial metabolism. The role of gut microbiota in chronic alcohol overconsumption should be investigated further.

• Komperød, Maren Jeanette; Sommer, Christine; Mellin-Olsen, Tonje; Iversen, Per Ole; Røseth, Arne & Valeur, Jørgen (2017). Persistent symptoms in patients with Crohn’s disease in remission: An exploratory study on the role of diet. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(5), s. 573–578. doi: 10.1080/00365521.2017.1397736. Fulltekst i vitenarkiv
• Hustoft, Tonje Nesvik; Hausken, Trygve; Ystad, Synne Otteraaen; Valeur, Jørgen; Brokstad, Karl Albert & Hatlebakk, Jan Gunnar [Vis alle 7 forfattere av denne artikkelen] (2017). Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Neurogastroenterology and Motility. ISSN 1350-1925. 29:e12969(4), s. 1–9. doi: 10.1111/nmo.12969. Fulltekst i vitenarkiv
• Vara, Ellen Johanne; Valeur, Jørgen; Hausken, Trygve & Lied, Gülen Arslan (2016). Extra-intestinal symptoms in patients with irritable bowel syndrome: related to high total IgE levels and atopic sensitization? Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 51(8), s. 908–913. doi: 10.3109/00365521.2016.1157890. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Berstad, Arnold & Valeur, Jørgen (2016). Systemic symptoms in irritable bowel syndrome: An investigative study on the role of enterocyte disintegrity, endotoxemia and inflammation. Molecular Medicine Reports. ISSN 1791-2997. 14(6), s. 5072–5076. doi: 10.3892/mmr.2016.5878. Fulltekst i vitenarkiv
• Kaur, Puneet; Bergrem, Astrid; Gerlyng, Per; Reims, Henrik Mikael; Leh, Sabine Maria & Valeur, Jørgen (2016). En metadonbruker med anemi, skjelettsmerter og endret utseende. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 136(10), s. 925–929. doi: 10.4045/tidsskr.15.0692. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan; Midtvedt, Tore & Valeur, Jørgen (2016). Probiotic lactic acid bacteria - the fledgling cuckoos of the gut? Microbial Ecology in Health and Disease. ISSN 0891-060X. 27(31557). doi: 10.3402/mehd.v27.31557. Fulltekst i vitenarkiv
• Valeur, Jørgen; Røseth, Arne; Knudsen, Torunn; Malmstrøm, Gunn Helen; Fiennes, Jennifer Twisleton & Midtvedt, Tore [Vis alle 7 forfattere av denne artikkelen] (2016). Fecal Fermentation in Irritable Bowel Syndrome: Influence of Dietary Restriction of Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols. Digestion. ISSN 0012-2823. 94(1), s. 50–56. doi: 10.1159/000448280. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Jakobsdottir, Greta; Nyman, Margareta; Berstad, Arnold & Valeur, Jørgen (2015). Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired colonic fermentation in patients with irritable bowel syndrome. Clinical and Experimental Gastroenterology. 8, s. 303–308. doi: 10.2147/CEG.S94084. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan & Valeur, Jørgen (2015). Indole - the scent of a healthy "inner soil". Microbial Ecology in Health and Disease. ISSN 0891-060X. 26. Fulltekst i vitenarkiv
• Valeur, Jørgen; Puaschitz, Nathalie Genevieve; Midtvedt, Tore & Berstad, Arnold (2015). Oatmeal porridge: Impact on microflora-associated characteristics in healthy subjects. British Journal of Nutrition. ISSN 0007-1145. 115(1), s. 62–67. doi: 10.1017/S0007114515004213. Fulltekst i vitenarkiv
• Valeur, Jørgen; Berstad, Arnold & Hausken, Trygve (2015). The effect of body position on postprandial perceptions, gastric emptying, and intragastric meal distribution: An ultrasonographic study in reclining healthy subjects. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 50(2), s. 170–173. doi: 10.3109/00365521.2014.990506. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan & Valeur, Jørgen (2014). Tryptophan: ‘essential’ for the pathogenesis of irritable bowel syndrome? Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 49(12), s. 1493–1498. doi: 10.3109/00365521.2014.936034. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Berstad, Arnold; Klow, Nils-Einar; Arnljot, Kristine; Moi, Kristin Skjeggestad & Valeur, Jørgen (2014). Abnormal accumulation of intestinal fluid following ingestion of an unabsorbable carbohydrate in patients with irritable bowel syndrome: an MRI study. Neurogastroenterology and Motility. ISSN 1350-1925. 26(12), s. 1686–1693. doi: 10.1111/nmo.12449. Fulltekst i vitenarkiv
• Lied, Gülen Arslan; Lillestøl, Kristine & Valeur, Jørgen (2013). Matintoleranse og allergi i gastrointestinaltraktus. I Fjellstad, Trygve & Fjeldstad, Trygve (Red.), Norsk legemiddelhåndbok for helsepersonell 2013. Fagbokforlaget. ISSN 9788290732115. s. 444–446. Fulltekst i vitenarkiv
• Valeur, Jørgen (2013). Gluten alene gir ikke irritabel tarm. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 133(17), s. 1814–1814. doi: 10.4045/tidsskr.13.0918. Fulltekst i vitenarkiv
• Lind, Ragna Anne; Berstad, Arnold; Hatlebakk, Jan G & Valeur, Jørgen (2013). Chronic fatigue in patients with unexplained self-reported food hypersensitivity and irritable bowel syndrome: validation of a Norwegian translation of the Fatigue Impact Scale. Clinical and Experimental Gastroenterology. 6, s. 101–107. doi: 10.2147/CEG.S45760. Fulltekst i vitenarkiv
• Valeur, Jørgen (2012). Glutenintoleranse uten cøliaki. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 132(5), s. 519–519. doi: 10.4045/tidsskr.12.0070. Fulltekst i vitenarkiv
• Valeur, Jørgen & Hausken, Trygve (2012). Oppblåst mage uten gass. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 132(21), s. 2400–2400. Fulltekst i vitenarkiv
• Berstad, Arnold; Undseth, Ragnhild M; Lind, Ragna & Valeur, Jørgen (2012). Functional bowel symptoms, fibromyalgia and fatigue: A food-induced triad? Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 47(8-9), s. 914–919. doi: 10.3109/00365521.2012.690045. Fulltekst i vitenarkiv
• Hausken, Trygve & Valeur, Jørgen (2012). Stillingsavhengig dyspepsi. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 132(12-13), s. 1461–1461. Fulltekst i vitenarkiv
• Lied, Gülen Arsland; Lillestøl, Kristine; Lind, Ragna; Valeur, Jørgen; Morken, Mette Helvik & Vaali, Kirsi Kaarina [Vis alle 10 forfattere av denne artikkelen] (2011). Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 46(10), s. 1169–1178. doi: 10.3109/00365521.2011.591428. Fulltekst i vitenarkiv
• Berstad, Arnold; Valeur, Jørgen; Lillestøl, Kristine; Lind, Ragna; Morken, Mette Helvik & Gregersen, Kine [Vis alle 8 forfattere av denne artikkelen] (2011). Matoverfølsomhet- Et paradigmeskifte? Fagbladet Allergi i praksis. ISSN 0806-5462. 1, s. 30–33. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2011). Dessertmage. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 131(24), s. 2453–2453. Fulltekst i vitenarkiv
• Valeur, Jørgen; Berstad, Arnold & Midtvedt, Tore (2011). Intestinal autointoksikasjon - fortsatt aktuell sykdomsmekanisme? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 131(19), s. 1875–1876. Fulltekst i vitenarkiv
• Gregersen, Kine; Valeur, Jørgen; Lillestøl, Kristine; Frøyland, Livar; Araujo, Hernandez Pedro W. & Lied, Gülen Arsland [Vis alle 7 forfattere av denne artikkelen] (2011). Subjective food hypersensitivity: assessment of enterochromaffin cell markers in blood and gut lavage fluid. International Journal of General Medicine. 4, s. 555–560. doi: 10.2147/IJGM.S18349. Fulltekst i vitenarkiv Vis sammendrag

  Background: Food hypersensitivity is commonly suspected, but seldom verified. Patients with subjective food hypersensitivity suffer from both intestinal and extraintestinal health complaints. Abnormalities of the enterochromaffin cells may play a role in the pathogenesis. The aim of this study was to investigate enterochromaffin cell function in patients with subjective food hypersensitivity by measuring serum chromogranin A (CgA) and 5-hydroxytryptamine (5-HT, serotonin) in gut lavage fluid. Methods: Sixty-nine patients with subjective food hypersensitivity were examined. Twenty-three patients with inflammatory bowel disease and 35 healthy volunteers were included as comparison groups. CgA was measured in serum by enzyme-linked immunosorbent assay. Gut lavage fluid was obtained by administering 2 L of polyethylene glycol solution intraduodenally. The first clear fluid passed per rectum was collected and 5-HT was analyzed by liquid chromatography tandem mass spectrometry. Results: Serum levels of CgA were significantly lower in patients with subjective food hypersensitivity than in healthy controls (P 0.04). No differences were found in 5-HT levels in gut lavage fluid between patients with subjective food hypersensitivity and the control groups. There was no correlation between serum CgA and gut lavage 5-HT. Conclusion: Decreased blood levels of CgA suggest neuroendocrine alterations in patients with subjective food hypersensitivity. However, 5-HT levels in gut lavage fluid were normal.

• Berstad, Arnold; Valeur, Jørgen; Lillestøl, Kristine; Lind, Ragna; Morken, Mette Helvik & Gregersen, Kine [Vis alle 9 forfattere av denne artikkelen] (2011). Pasienten tåler ikke mat - hva skal vi tro? Utposten. ISSN 0800-5680. 40(5), s. 36–40. Fulltekst i vitenarkiv
• Lind, Ragna; Lied, Gülen Arsland; Lillestøl, Kristine; Valeur, Jørgen & Berstad, Arnold (2010). Do psychological factors predict symptom severity in patients with subjective food hypersensitivity? Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 45(7-8), s. 835–843. doi: 10.3109/00365521003797213. Fulltekst i vitenarkiv
• Lind, Ragna; Lillestøl, Kristine; Valeur, Jørgen; Eriksen, Hege Randi; Tangen, Tone & Berstad, Arnold [Vis alle 7 forfattere av denne artikkelen] (2010). Job stress and coping strategies in patients with subjective food hypersensitivity. Scandinavian Journal of Psychology. ISSN 0036-5564. 59(2), s. 179–184. doi: 10.1111/j.1467-9450.2009.00761.x. Fulltekst i vitenarkiv
• Rønnevik, Alexander K.; Valeur, Jørgen & Berstad, Arnold (2010). Kan tarmbakteriene gjøre oss fete? Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. 8(3), s. 12-14–16-17. Fulltekst i vitenarkiv
• Lied, Gülen Arsland; Lillestøl, Kristine; Valeur, Jørgen & Berstad, Arnold (2010). Intestinal B cell-activating factor: an indicator of non-IgE mediated hypersensitivity reactions to food? Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 32(1), s. 66–73. doi: 10.1111/j.1365-2036.2010.04314.x. Fulltekst i vitenarkiv
• Gregersen, Kine; Lind, Ragna; Valeur, Jørgen; Bjørkkjær, Tormod; Berstad, Arnold & Lied, Gülen Arsland (2010). Duodenal administered seal oil for patients with subjective food hypersensitivity: an explorative open pilot study. International Journal of General Medicine. 3, s. 383–392. doi: 10.2147/IJGM.S13013. Fulltekst i vitenarkiv Vis sammendrag

  Short-term duodenal administration of n-3 polyunsaturated fatty acid (PUFA)-rich seal oil may improve gastrointestinal complaints in patients with subjective food hypersensitivity, as well as joint pain in patients with inflammatory bowel disease (IBD). The aim of the present explorative pilot study was to investigate whether 10-day open treatment with seal oil, 10 mL self-administrated via a nasoduodenal tube 3 times daily, could also benefit nongastrointestinal complaints and quality of life (QoL) in patients with subjective food hypersensitivity. Twenty-six patients with subjective food hypersensitivity, of whom 25 had irritable bowel syndrome (IBS), were included in the present study. Before and after treatment and 1 month posttreatment, patients filled in the Ulcer Esophagitis Subjective Symptoms Scale (UESS) and the Gastrointestinal Symptom Rating Scale (GSRS) for gastrointestinal symptoms and subjective health complaints (SHC) inventory for nongastrointestinal symptoms in addition to short form of the Nepean dyspepsia index (SF-NDI) for evaluation of QoL. Compared with baseline, gastrointestinal, as well as nongastrointestinal, complaints and QoL improved significantly, both at end of treatment and 1 month posttreatment. The consistent improvements following seal oil administration warrant further placebo-controlled trials for confirmation of effect.

• Valeur, Jørgen; Morken, Mette Helvik; Norin, E; Midtvedt, T & Berstad, Arnold (2010). Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective? Clinical and Experimental Gastroenterology. 3, s. 65–70. Fulltekst i vitenarkiv
• Hystad, Hilde Tang; Valeur, Jørgen & Berstad, Arnold (2010). Bør personer med irritabel tarm spise mindre tungt fordøyelige karbohydrater? Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. s. 12–17. Fulltekst i vitenarkiv
• Lillestøl, Kristine; Helgeland, Lars Inge; Lied, Gülen Arsland; Florvaag, Erik; Valeur, Jørgen & Lind, Ragna [Vis alle 7 forfattere av denne artikkelen] (2010). Indications of 'atopic bowel' in patients with self-reported food hypersensitivity. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 31(10), s. 1112–1122. doi: 10.1111/j.1365-2036.2010.04261.x. Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Norin, Elisabeth; Midtvedt, Tore & Berstad, Arnold (2009). Carbohydrate intolerance in patients with self-reported food hypersensitivity: Comparison of lactulose and glucose. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(12), s. 1416–1423. Fulltekst i vitenarkiv
• Landsvik, Hanne Sylte; Valeur, Jørgen & Berstad, Arnold (2009). Helseeffekter av probiotika - en kritisk vurdering. Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. 7(2), s. 22–26. Fulltekst i vitenarkiv
• Morken, Mette Helvik; Lind, Ragna; Valeur, Jørgen; Wilhelmsen, Ingvard & Berstad, Arnold (2009). Subjective health complaints and quality of life in patients with irritable bowel syndrome following Giardia lamblia infection: A case control study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(3), s. 308–313. doi: 10.1080/00365520802588091. Fulltekst i vitenarkiv
• Morken, Mette Helvik; Valeur, Jørgen; Norin, Elisabeth; Midtvedt, Tore; Nysæter, Gunnar & Berstad, Arnold (2009). Antibiotic or bacterial therapy in post-giardiasis irritable bowel syndrome. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(11), s. 1296–1303. doi: 10.3109/00365520903274401. Fulltekst i vitenarkiv
• Valeur, Jørgen; Lappalainen, Jani; Rita, Hannu; Lin, Aung Htun; Kovanen, Petri T. & Berstad, Arnold [Vis alle 8 forfattere av denne artikkelen] (2009). Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model. BMC Gastroenterology. 9. doi: 10.1186/1471-230X-9-33. Fulltekst i vitenarkiv Vis sammendrag

  Background: We hypothesized that food allergy causes a state of non-specific jejunal dysmotility. This was tested in a mouse model. Methods: Balb/c mice were epicutaneously sensitized with ovalbumin and challenged with 10 intragastric ovalbumin administrations every second day. Smooth muscle contractility of isolated circular jejunal sections was studied in organ bath with increasing concentrations of carbamylcholine chloride (carbachol). Smooth muscle layer thickness and mast cell protease-1 (MMCP-1) positive cell density were assayed histologically. Serum MMCP-1 and immunoglobulins were quantified by ELISA, and mRNA expressions of IFN-γ, IL-4, IL-6 and TGFβ-1 from jejunal and ileal tissue segments were analyzed with quantitative real-time PCR. Results: Ovalbumin-specific serum IgE correlated with jejunal MMCP-1+ cell density. In the allergic mice, higher concentrations of carbachol were required to reach submaximal muscular stimulation, particularly in preparations derived from mice with diarrhoea. Decreased sensitivity to carbachol was associated with increased expression of IL-4 and IL-6 mRNA in jejunum. Smooth muscle layer thickness, as well as mRNA of IFN-γ and TGF-β1 remained unchanged. Conclusion: In this mouse model of food allergy, we demonstrated a decreased response to a muscarinic agonist, and increased levels of proinflammatory IL-6 and Th2-related IL-4, but not Th1- related IFN-γ mRNAs in jejunum. IgE levels in serum correlated with the number of jejunal MMCP- 1+ cells, and predicted diarrhoea. Overall, these changes may reflect a protective mechanism of the gut in food allergy.

• Jarlsby, Ragnhild; Valeur, Jørgen & Berstad, Arnold (2008). Laktosemalabsorbsjon - en fordel? Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. s. 10–13. Fulltekst i vitenarkiv
• Valeur, Jørgen; Øines, Eliann; Morken, Mette Helvik; Holst, Jens Juul & Berstad, Arnold (2008). Plasma glucagon-like peptide 1 and peptide YY levels are not altered in symptomatic fructose-sorbitol malabsorption. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 43, s. 1212–1218. doi: 10.1080/00365520802116448. Fulltekst i vitenarkiv

Se alle arbeider i NVA

• Enders, Giulia & Valeur, Jørgen (2015). Sjarmen med tarmen. Om et av kroppens mest undervurderte organer. Skrevet av Giulia Enders med forord av Jørgen Valeur: "På oppdagelsesferd i det indre rom". Cappelen Damm AS. ISBN 9788202455668. 290 s. Fulltekst i vitenarkiv
• Edin, Julia Døhlen; Valeur, Jørgen; Mellin-Olsen, Tonje & Knudsen, Torunn (2015). LavFODMAP - magevennlig mat. Kokeboka for deg som har sensitiv mage, irritabel tarm eller matintoleranse. Cappelen Damm AS. ISBN 9788202480684. 152 s. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2009). Inspeksjon av feces. En praktisk tilnærming. Den norske legeforening. ISBN 9788280700735. 0 s. Fulltekst i vitenarkiv

Se alle arbeider i NVA

• Valeur, Jørgen & Haug, Camilla Spersrud (2025). Ventrikkelslimhinne i rektum. doi: 10.4045/tidsskr.25.0492. Fulltekst i vitenarkiv
• Valeur, Jørgen (2025). Ny vin i gammel flaske? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. Fulltekst i vitenarkiv
• Bu, Fanny; Valeur, Jørgen; Johnson, Katerina & Brummer, Robert J (2025). Mener kosttilskudd kan gi bedre humør – på bare to uker. [Internet]. Tv2.no. Fulltekst i vitenarkiv
• Hanes, Emma & Valeur, Jørgen (2025). Nyt kaffen med god samvittighet. [Internet]. www.klikk.no. Fulltekst i vitenarkiv
• Maseng, Maria Gjerstad; Hansen, S Hyll; Bang, Corina; Valeur, Jørgen; Huppertz-Hauss, Gert & Opheim, Randi [Vis alle 18 forfattere av denne artikkelen] (2025). Longitudinal Changes in Gut Microbiota During the First Year following diagnosis of Inflammatory Bowel Disease – the IBSEN III study. Journal of Crohn's and Colitis. ISSN 1873-9946. 19, s. i2387–i2387. doi: 10.1093/ecco-jcc/jjae190.1498. Fulltekst i vitenarkiv
• Bekkelund, Mattis; Juul, Frederik Emil; Sandstad, Olav & Valeur, Jørgen (2025). Bakteriell overdiagnostikk i tynntarm. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 145. doi: 10.4045/tidsskr.24.0655. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Valeur, Jørgen; Brønstad, Ingeborg; Gilja, Odd Helge & Hatlebakk, Jan Gunnar (2025). The possible role of butyric acid in long-term symptom relief in irritable bowel syndrome patients following fecal microbiota transplantation. Fulltekst i vitenarkiv
• Solberg, Trine & Valeur, Jørgen (2025). Kjempestudie om tarmbakterier: Dette bør du spise. [Internet]. Nettavisen. Fulltekst i vitenarkiv
• Maseng, Maria Gjerstad; Hansen, Simen Hyll; Bang, Corina; Valeur, Jørgen; Huppertz-Hauss, Gert & Opheim, Randi [Vis alle 18 forfattere av denne artikkelen] (2025). Longitudinal Changes in Gut Microbiota During the First Year following diagnosis of Inflammatory Bowel Disease – the IBSEN III study. Fulltekst i vitenarkiv
• Bekkelund, Mattis; Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Dale, Hanna Fjeldheim & Jacobsen, Birgitte Berentsen (2025). Effekt av en lav-FODMAP-diett på visceral hypersensitivitet ved irritabel tarm-syndrom. Fulltekst i vitenarkiv
• Bekkelund, Mattis; Sangnes, Dag André; Steinsvik, Elisabeth Kjelsvik; Søfteland, Eirik; Dimcevski, Georg & Valeur, Jørgen (2025). Autonom nevropati hos pasienter med diabetes og symptomer på gastroenteropati. Fulltekst i vitenarkiv
• Bekkelund, Mattis; Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Søfteland, Eirik; Dimcevski, Georg & Sangnes, Dag André (2025). Kliniske karakteristika ved diabetisk gastroparese. Fulltekst i vitenarkiv
• Valeur, Jørgen (2025). «Tarmkultur» - magetarmsystemets betydning i mytologi, historie, kultur og kunst. Fulltekst i vitenarkiv
• Valeur, Jørgen (2025). «Tarmkultur» - magetarmsystemets betydning i mytologi, historie, kultur og kunst. Fulltekst i vitenarkiv
• Valeur, Jørgen & Hem, Erlend (2025). Larmen fra tarmen. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 145. doi: 10.4045/tidsskr.25.0069. Fulltekst i vitenarkiv
• Valeur, Jørgen (2025). Dinosaurmagefest. NGF-nytt. ISSN 0809-6570. 32(1), s. 48–48. Fulltekst i vitenarkiv
• Bekkelund, Mattis; Sangnes, Dag André; Steinsvik, Elisabeth Kjelsvik; Søfteland, Eirik; Dimcevski, Georg & Valeur, Jørgen (2025). Autonom nevropati hos pasienter med diabetes og symptomer på gastroenteropati. NGF-nytt. ISSN 0809-6570. 32, s. 24–25. Fulltekst i vitenarkiv
• Valeur, Jørgen (2025). Avføring som terapi - historisk overblikk. Fulltekst i vitenarkiv
• Sollund, Adrian; Røssberg, Jan Ivar & Valeur, Jørgen (2025). Antidepressiva: Nye sjokkfunn. [Internet]. Dagbladet.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2025). Tarmfloratilpasset medisin. Fulltekst i vitenarkiv
• Klevstul, Miriam; Olsen, Peder Sandvold; Norin, Elisabeth; Valeur, Jørgen; Røseth, Arne & Johansson, Mads (2025). Tilbyder av fekal transplantasjon stoppet av statlig instans: - Dette er David mot Goliat. [Journal]. Fordøyelsen. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Valeur, Jørgen; Brønstad, Ingeborg; Gilja, Odd Helge & Hatlebakk, Jan Gunnar (2025). Kortkjedede fettsyrer etter FMT. Fulltekst i vitenarkiv
• Halsne, Ruth & Valeur, Jørgen (2024). Nanomateriale med karbon brytes ned av bakterier i tarmen. [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). doi: 10.4045/tidsskr.23.0841. Fulltekst i vitenarkiv
• Valeur, Jørgen & MIkalsen, Knut-Erik (2024). Frykter du ubehag på flyturen? Dette er løsningen. [Internet]. Flysmart24.no. Fulltekst i vitenarkiv
• Hem, Erlend; Roos, Merethe & Valeur, Jørgen (2024). Rolv Gjessing - den tvetydige pioneren. 21(4), s. 473–481. doi: 10.56175/michael.11938. Fulltekst i vitenarkiv
• Hem, Erlend; Roos, Merethe & Valeur, Jørgen (2024). Rolv Gjessing - et hundreårsminne. Michael. ISSN 1893-9651. 21(4), s. 385–386. doi: 10.56175/michael.11931. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). Kryp i magen. NGF-nytt. ISSN 0809-6570. 31(4), s. 36–36. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). Forsideillustrasjon til NGF-nytt nr. 4 2024. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). Irritabel tarm-syndrom (IBS): Symptomer, patofysiologi og behandling. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). Noe å tygge på. NGF-nytt. ISSN 0809-6570. 31(2), s. 34–34. Fulltekst i vitenarkiv
• Jensen, Caroline; Martinsen, Tilde Kristine; Valeur, Jørgen; Nygård, Ottar Kjell & Lied, Gülen Arslan (2024). Gastrointestinal symptoms and associations with faecal SCFAs and dietary intake in older adults - results from the Hordaland Health Studie 3. Fulltekst i vitenarkiv
• Rosman, Mari; Lundin, Knut & Valeur, Jørgen (2024). Tarmen din lekker. [Journal]. Fordøyelsen. Fulltekst i vitenarkiv
• Valeur, Jørgen; Tveito, Kari; Røseth, Arne; Strøm, Finn; Kristensen, Vendel Ailin & Sandstad, Olav [Vis alle 9 forfattere av denne artikkelen] (2024). Minneord: Viggo Øystein Skar (1945-2024). Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 144(14), s. 1155–1155. Fulltekst i vitenarkiv
• Tovan, Anders Ihle; Valeur, Jørgen & Johansson, Mads J. (2024). Nye IBS-funn: Kan gi stor symptomlindring. [Internet]. VG. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). Pytonslangens prandiale pekuliaritet. NGF-nytt. ISSN 0809-6570. 31(1), s. 44–44. Fulltekst i vitenarkiv
• Hollekim, Thea Elisabeth; Thorud, Oda Myrvold & Valeur, Jørgen (2024). Funksjonelle mage- og tarmlidelser (IBS). [Internet]. Tarmlyd (podcast). Fulltekst i vitenarkiv
• Ingebrigtsen, Julia Renate; Valeur, Jørgen; Zinöcker, Marit; Spurkland, Anne & Østvik, Ann Elisabeth (2024). Eksperter: Dette kan du gjøre for å unngå kronisk inflammasjon. [Journal]. VG. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). «Tarmkultur» - magetarmsystemets betydning i mytologi, historie, kultur og kunst. Fulltekst i vitenarkiv
• Maseng, Maria Gjerstad; Hansen, Simen Hyll; Bang, Corina; Detlie, Trond Espen; Huppertz-Hauss, Gert & Kristensen, Vendel Ailin [Vis alle 18 forfattere av denne artikkelen] (2024). Longitudinal Changes in Gut Microbiota During the First Year following diagnosis of Inflammatory Bowel Disease– the IBSEN III study. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Valeur, Jørgen; Brønstad, Ingeborg; Gilja, Odd Helge & Hatlebakk, Jan Gunnar (2024). Faecal butyric acid levels are increased at 2 and 3 years after faecal microbiota transplantation (FMT) in patients with irritable bowel syndrome (IBS). Fulltekst i vitenarkiv
• Strømland, Stine Sofie; Aspholm, Trude; Fjørtoft, Jenny; Brønner, Charlotte Utheim; Stolt, Emma & Snipen, Lars-Gustav [Vis alle 12 forfattere av denne artikkelen] (2024). Effects of sulfur amino acid restriction on gut microbiota and inflammation in people with overweight and obesity: an 8-week randomized controlled dietary intervention study. Fulltekst i vitenarkiv
• Juul, Frederik Emil; Bretthauer, Michael; Tonby, Kristian; Berdal, Jan-Erik; Hoff, Dag Arne Lihaug & Ofstad, Eirik Hugaas [Vis alle 27 forfattere av denne artikkelen] (2024). Fecal microbiota transplant versus Vancomycin for primary Clostridioides difficile infection - a randomized non-inferiority trial. Fulltekst i vitenarkiv
• Valeur, Jørgen & Rickers, Andreas Lykke (2024). Trang vinkel mellom a. mesenterica superior og aorta. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 144(2). doi: 10.4045/tidsskr.23.0756. Fulltekst i vitenarkiv
• Lindseth, Inge Andreas; Villmones, Heidi Cecilie & Valeur, Jørgen (2024). Tarmflora med feil adresse? [Journal]. Sunnhetsbladet. Fulltekst i vitenarkiv
• Valeur, Jørgen (2024). Stjernemage. NGF-nytt. ISSN 0809-6570. 31(3), s. 42–42. Fulltekst i vitenarkiv
• Sollund, Adrian & Valeur, Jørgen (2024). Omstridt IBS-diett hjalp Cecilie. [Journal]. Dagbladet. Fulltekst i vitenarkiv
• Sollund, Adrian; Zinöcker, Marit & Valeur, Jørgen (2024). Formelen: Kvitt IBS-plagene. [Internet]. Dagbladet. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Valeur, Jørgen; Brønstad, Ingeborg; Gilja, Odd Helge & Hatlebakk, Jan Gunnar (2024). Faecal butyric acid levels are increased at 2 and 3 years after faecal microbiota transplantation (FMT) in patients with irritable bowel syndrome (IBS). Neurogastroenterology and Motility. ISSN 1350-1925. 36, s. 144–144. Fulltekst i vitenarkiv
• Valeur, Jørgen (2023). Å puste med magen. NGF-nytt. ISSN 0809-6570. 30(2), s. 36–36. Fulltekst i vitenarkiv
• Valeur, Jørgen (2023). Strutsens stålmage. NGF-nytt. ISSN 0809-6570. 30(1), s. 54–54. Fulltekst i vitenarkiv
• Valeur, Jørgen (2023). Funksjonelle lidelser i øvre GI-traktus. Fulltekst i vitenarkiv
• Valeur, Jørgen (2023). Forsideillustrasjon til NGF-nytt nr. 4 2023. Fulltekst i vitenarkiv
• Valeur, Jørgen (2023). Kulemage. NGF-nytt. ISSN 0809-6570. 30(4), s. 40–40. Fulltekst i vitenarkiv
• Sangnes, Dag André; Engjom, Trond; Løvaas, Kristian; Berentsen, Birgitte; Softeland, Eirik & Dimcevski, Georg Gjorgji [Vis alle 19 forfattere av denne artikkelen] (2023). Epidemiologi og patofysiologi ved diabetisk diaré (DIAREPA). Fulltekst i vitenarkiv
• Hansen, Simen Hyll; Maseng, M Gjerstad; Bjørkqvist, O; Halfvarsson, J; Bang, C & Detlie, Trond Espen [Vis alle 23 forfattere av denne artikkelen] (2023). Gut microbiota at diagnosis is associated with clinical features and future disease course in Inflammatory Bowel Disease: Data from IBSEN III, a new large Norwegian population-based inception cohort. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, s. i1028–I2029. doi: 10.1093/ecco-jcc/jjac190.1050. Fulltekst i vitenarkiv
• Bergseth, Wilma; Garnås, Eirik; Hatlebakk, Jan Gunnar & Valeur, Jørgen (2023). Expert: Så kan viss kost minska IBS-symtom. [Internet]. Aftonbladet. Fulltekst i vitenarkiv
• Bergseth, Wilma; Garnås, Eirik; Hatlebakk, Jan Gunnar & Valeur, Jørgen (2023). IBS-funn: − Kan gi betydelig symptomreduksjon. [Internet]. VG. Fulltekst i vitenarkiv
• Strøm, Anne-Karine & Valeur, Jørgen (2023). Derfor er tarmen så viktig for helsen. [Journal]. Vi over 60. Fulltekst i vitenarkiv
• Juul, Frederik Emil; Hov, Johannes Espolin Roksund; Trøseid, Marius; Johnsen, Peter Holger & Valeur, Jørgen (2023). Tarmflora og tarmsykdom - en edruelig formaning. 143(10), s. 849–850. doi: 10.4045/tidsskr.23.0121. Fulltekst i vitenarkiv
• Valeur, Jørgen (2023). Illustrasjoner til boken Steinsvik EK, Larsen CH, Hausken T. Skitt la gå. Løst og fast om plager, sykdom og resten av tarmens forunderlige liv. Fulltekst i vitenarkiv
• Zerouga, Insaf; Sommer, Christine; Carlsen, Monica Hauger; Valeur, Jørgen; Kristensen, Vendel Ailin & Høivik, Marte Lie [Vis alle 8 forfattere av denne artikkelen] (2023). Kosthold og ernæringsstatus ved nydiagostisert IBD: resultater fra IBSEN III. Fulltekst i vitenarkiv
• Årdal, Ingrid G.; Jakobsen, Celina; Zinöcker, Marit; Valeur, Jørgen & Villmones, Heidi Cecilie (2023). Celina (27) har hatt laus mage i ni år – så endra ho kosthaldet. [Internet]. nrk.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2023). Vampyrmage. NGF-nytt. ISSN 0809-6570. 30(3), s. 34–35. Fulltekst i vitenarkiv
• Bekkelund, Mattis; Sangnes, Dag André; Valeur, Jørgen & Hatlebakk, Jan Gunnar (2023). Nausea associated to subsegmental intestinal hypomotility in diabetic gastroenteropathy. Fulltekst i vitenarkiv
• Teige, Erica Sande; Hillestad, Eline Margrete Randulff; Steinsvik, Elisabeth Kjelsvik; Brønstad, Ingeborg; Bjørkevoll, M & Straume, Mariell Gaassand [Vis alle 14 forfattere av denne artikkelen] (2022). Bergen Braingut Study: Relations between fecal microbiota profile and its metabolites (short-chain fatty acids) and symptoms in irritable bowel syndrome. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 10, s. 412–412. Fulltekst i vitenarkiv
• Teige, Erica Sande; Hillestad, EM; Steinsvik, Elisabeth Kjelsvik; Brønstad, Ingeborg; Bjørkevoll, M & Straume, Mariell Gaassand [Vis alle 14 forfattere av denne artikkelen] (2022). Bergen Braingut Study: Relations between fecal microbiota profile and its metabolites (short-chain fatty acids) and symptoms in irritable bowel syndrome. Fulltekst i vitenarkiv
• Roos, Merethe; Lillestøl, Kristine & Valeur, Jørgen (2022). Dr. Sopp: Markant mykolog - og mye mer. Michael. ISSN 1893-9651. 19(4), s. 333–335. Fulltekst i vitenarkiv
• Valeur, Jørgen (2022). Soppenes planet. Michael. ISSN 1893-9651. 19(4), s. 409–410. Fulltekst i vitenarkiv
• Valeur, Jørgen (2022). Engastrasjon. NGF-nytt. ISSN 0809-6570. 29(3), s. 38–38. Fulltekst i vitenarkiv
• Valeur, Jørgen (2022). Urtarmdyret. NGF-nytt. ISSN 0809-6570. 29(2), s. 42–42. Fulltekst i vitenarkiv
• Valeur, Jørgen (2022). Mikrobiota - tarmflora. Fulltekst i vitenarkiv
• Valeur, Jørgen (2022). Forsideillustrasjon til NGF-nytt nr. 4 2022. Fulltekst i vitenarkiv
• Valeur, Jørgen (2022). Maur i magen. NGF-nytt. ISSN 0809-6570. 29(4), s. 38–39. Fulltekst i vitenarkiv
• Simonsen, Michael; Villmones, Heidi Cecilie; Valeur, Jørgen; Husebye, Einar & Hov, Johannes Espolin Roksund (2022). - Studien kan gi ny innsikt i kroniske tarmplager. [Internet]. Dagens Medisin. Fulltekst i vitenarkiv
• Valeur, Jørgen (2022). Firkantmysteriet. NGF-nytt. ISSN 0809-6570. 29(1), s. 58–58. Fulltekst i vitenarkiv
• Valeur, Jørgen (2021). Middelaldersk magetømmingstest. NGF-nytt. ISSN 0809-6570. 28(3), s. 48–48. Fulltekst i vitenarkiv
• Valeur, Jørgen (2021). Funksjonelle lidelser i øvre GI-traktus. Fulltekst i vitenarkiv
• Valeur, Jørgen; Hausken, Trygve; Hatlebakk, Jan Gunnar; Lied, Gülen Arslan; Folvik, Geir & Lillestøl, Kristine [Vis alle 11 forfattere av denne artikkelen] (2021). Minneord: Arnold Berstad (1940-2020). Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 141(3), s. 293–293. Fulltekst i vitenarkiv
• Valeur, Jørgen (2021). Dovendyrets dobesøk. NGF-nytt. ISSN 0809-6570. 28(4), s. 34–34. Fulltekst i vitenarkiv
• Valeur, Jørgen (2021). Forsideillustrasjon til NGF-nytt nr. 4 2021. Fulltekst i vitenarkiv
• Valeur, Jørgen (2021). Frosk i magen. NGF-nytt. ISSN 0809-6570. 28(1), s. 45–45. Fulltekst i vitenarkiv
• Herfindal, Anne Mari; Megen, Frida van; Gilde, Mari Christine Overvik; Valeur, Jørgen; Rudi, Knut & Skodje, Gry Irene [Vis alle 9 forfattere av denne artikkelen] (2021). Effects of low-FODMAP diet on gut microbiota in individuals with treated celiac disease having persistent gastrointestinal symptoms. Fulltekst i vitenarkiv
• Stø, Kristine; Valeur, Jørgen; Ueland, Thor; Malmstrøm, Gunn Helen; Bjerkeli, Vigdis & Kazmi, Syed Sajid Hussain [Vis alle 10 forfattere av denne artikkelen] (2021). Increased fecal levels of the SCFA butyrate may indicate poor absorption due to disrupted gut barrier in patients with carotid stenosis. Fulltekst i vitenarkiv
• Lamøy, Berith Eva; Somby, Caroline; Valeur, Jørgen; Fadnes, Lars T. & Ebeltoft, Marit (2021). Caroline (26) byttet til lavkarbo: – Nå er magen fin. [Internet]. Norsk Ukeblad. Fulltekst i vitenarkiv
• Teige, Eirik Persson; Hillestad, Eline Margrete Randulff; Berentsen, Birgitte; Steinsvik, Elisabeth Kjelsvik; Brønstad, Ingeborg & Hausken, Trygve [Vis alle 9 forfattere av denne artikkelen] (2021). Kort- og langtidseffekten av lav FODMAP-dietten på symptomer og kortkjedede fettsyrer hos pasienter med irritabel tarmsyndrom. Fulltekst i vitenarkiv
• Lillestøl, Kristine & Valeur, Jørgen (2021). Gastroptose. NGF-nytt. ISSN 0809-6570. 28(2), s. 20–22. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Casén, Christina; Valeur, Jørgen; Hausken, Trygve & Hatlebakk, Jan Gunnar (2021). Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 9(S8), s. 635–636. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Casén, Christina; Valeur, Jørgen; Hausken, Trygve & Hatlebakk, Jan Gunnar (2021). Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Valeur, Jørgen (2020). Paris' mage. NGF-nytt. ISSN 0809-6570. 27(2), s. 28–28. Fulltekst i vitenarkiv
• Birkeland, Eline; Gharagozlian, Sedegheh; Birkeland, Kåre I.; Valeur, Jørgen; Måge, Ingrid & Rud, Ida [Vis alle 7 forfattere av denne artikkelen] (2020). Correction to: Prebiotic effect of inulin‑type fructans on faecal microbiota and short‑chain fatty acids in type 2 diabetes: a randomised controlled trial. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-020-02314-0. Fulltekst i vitenarkiv
• Valeur, Jørgen (2020). Spiraltarm. NGF-nytt. ISSN 0809-6570. 27(1), s. 44–44. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Valeur, Jørgen; Hausken, Trygve & Hatlebakk, Jan Gunnar (2020). Changes in fecal short-chain fatty acids (SCFA) following fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome (IBS). Neurogastroenterology and Motility. ISSN 1350-1925. 32. doi: 10.1111/nmo.13817. Fulltekst i vitenarkiv
• Teige, Erica Persson; Berentsen, Birgitte; Brønstad, Ingeborg; Hausken, Trygve; Hatlebakk, Jan Gunnar & Valeur, Jørgen [Vis alle 7 forfattere av denne artikkelen] (2020). Short and extended effects of a low FODMAP diet on symptoms and short-chained fatty acids in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Valeur, Jørgen (2020). Den mekaniske and. NGF-nytt. ISSN 0809-6570. 27(4), s. 31–31. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Kristoffersen, Anja Bråthen; Valeur, Jørgen; Casén, Christina; Hatlebakk, Jan Gunnar & Gilja, Odd Helge [Vis alle 7 forfattere av denne artikkelen] (2020). Long-term effects of faecal microbiota transplantation (FMT) in patients with irritable bowel syndrome. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. s. 46–46. Fulltekst i vitenarkiv
• El-Salhy, Magdy; Kristoffersen, Anja Bråthen; Valeur, Jørgen; Casén, Christina; Hatlebakk, Jan Gunnar & Gilja, Odd Helge [Vis alle 7 forfattere av denne artikkelen] (2020). Long-term effects of faecal microbiota transplantation (FMT) in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Valeur, Jørgen (2020). Forsideillustrasjon til NGF-nytt nr. 4 2020. Fulltekst i vitenarkiv
• Byklum, Kari; Valeur, Jørgen; Mjølstad, Bente Prytz & Sundtoft, Tine (2020). Kvitt deg med luften i magen. [Journal]. Norsk ukeblad. Fulltekst i vitenarkiv
• Valeur, Jørgen (2020). Will it float? NGF-nytt. ISSN 0809-6570. 27(3), s. 35–35. Fulltekst i vitenarkiv
• Juul, Frederik Emil & Valeur, Jørgen (2019). Tarmflorabehandling. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 139(9), s. 859–859. doi: 10.4045/tidsskr.19.0058. Fulltekst i vitenarkiv
• Farup, Per Grønaas; Lydersen, Stian & Valeur, Jørgen (2019). Are non-nutritive sweeteners obesogenic by altering the faecal microbiota and their metabolites? Fulltekst i vitenarkiv
• Farup, Per Grønaas & Valeur, Jørgen (2019). Are non-nutritive sweeteners obesogenic by altering fecal short-chain fatty acids? Fulltekst i vitenarkiv
• Valeur, Jørgen (2019). Honningmage. NGF-nytt. ISSN 0809-6570. 26(2), s. 30–30. Fulltekst i vitenarkiv
• Valeur, Jørgen (2019). Toalett i særklasse. NGF-nytt. ISSN 0809-6570. 26(1), s. 37–37. Fulltekst i vitenarkiv
• Edin, Julia Døhlen & Valeur, Jørgen (2019). Når avføring selges som mirakelkur. [Journal]. Fordøyelsen. Fulltekst i vitenarkiv
• Juul, Frederik Emil & Valeur, Jørgen (2019). Tilsvar til Frøland SS. Fekaltransplantasjon og mikrobiom. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 139(11), s. 1020–1020. Fulltekst i vitenarkiv
• Gaarder, Jorun; Lindberg, Fedon & Valeur, Jørgen (2019). - Slik ble jeg kvitt IBS. [Journal]. Dagbladet. Fulltekst i vitenarkiv
• Valeur, Jørgen (2019). Strupesekk. NGF-nytt. ISSN 0809-6570. 26(3), s. 32–32. Fulltekst i vitenarkiv
• Valeur, Jørgen (2019). Kamelens mage. NGF-nytt. ISSN 0809-6570. 26(4), s. 24–25. Fulltekst i vitenarkiv
• Valeur, Jørgen (2019). Forsideillustrasjon til NGF-nytt nr. 4 2019. Fulltekst i vitenarkiv
• Mazzawi, Tarek; Hausken, Trygve; Hov, Johannes Espolin Roksund; Valeur, Jørgen; Sangnes, Dag André & El-Salhy, Magdy [Vis alle 9 forfattere av denne artikkelen] (2019). Effect of faecal microbiota transplantation on gut microenvironment and symptoms in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Kristensen, Vendel Ailin; Valeur, Jørgen; Brackmann, Stephan; Jahnsen, Jørgen & Tveito, Kari (2019). Kognitive symptomer hos pasienter med cøliaki før og etter glutenfri kost. Fulltekst i vitenarkiv
• Juul, Frederik Emil & Valeur, Jørgen (2019). Snille bakterier finnes ikke. 139(6), s. 504–505. doi: 10.4045/tidsskr.19.0134. Fulltekst i vitenarkiv
• Moore, Alison M.; Mathias, Manon & Valeur, Jørgen (2018). Contextualising the microbiota–gut–brain axis in history and culture. Microbial Ecology in Health and Disease. ISSN 0891-060X. 29. Fulltekst i vitenarkiv
• Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Hausken, Trygve & Gilja, Odd Helge (2018). Psychological factors in patients with functional gastrointestinal disorders: relation to dyspeptic symptoms and gastric dysmotility as measured with ultrasound. Fulltekst i vitenarkiv
• Kristensen, Vendel Ailin; Valeur, Jørgen & Tveito, Kari (2018). Cognitive impairment in coeliac disease: normalization following gluten-free diet. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 6, s. A330–A330. Fulltekst i vitenarkiv
• Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Hausken, Trygve & Gilja, Odd Helge (2018). Psychological factors in patients with functional gastrointestinal disorders: relation to dyspeptic symptoms and gastric dysmotility as measured with ultrasound. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 6, s. A506–A506. Fulltekst i vitenarkiv
• Kristensen, Vendel Ailin; Valeur, Jørgen & Tveito, Kari (2018). Cognitive impairment in coeliac disease: normalization following gluten-free diet. Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Forsideillustrasjon til NGF-nytt nr. 4 2018. Fulltekst i vitenarkiv
• Valeur, Jørgen & Rogde, Sidsel (2018). Mynter i magen. NGF-nytt. ISSN 0809-6570. 25(4), s. 26–26. Fulltekst i vitenarkiv
• Hammersmark, Karoline Berge; Lundin, Knut Erik Aslaksen; Lyngstad, Julianne & Valeur, Jørgen (2018). Ekspertenes råd mot oppblåst mage. [Internet]. Nrk.no. Fulltekst i vitenarkiv
• Rødahl, Jenny Mina; Dale, Hanna Fjeldheim & Valeur, Jørgen (2018). Senk tarmens biologiske alder. [Journal]. Dagbladet. Fulltekst i vitenarkiv
• Nilsen, Lisbeth; Hov, Johannes Espolin Roksund; Trøseid, Marius; Valeur, Jørgen & Midtvedt, Tore (2018). Forsker på om tarmbakteriene kan forutsi sykdom. [Journal]. Dagens Medisin. Fulltekst i vitenarkiv
• Malvik, Stine; Bjørkhaug, Steinar Traae; Valeur, Jørgen & Henriksen, Christine (2018). Ernæringsstatus hos personer med høyt alkoholinntak. Fulltekst i vitenarkiv
• Komperød, Maren Jeanette; Sommer, Christine; Mellin-Olsen, Tonje; Iversen, Per Ole; Røseth, Arne & Valeur, Jørgen (2018). Vedvarende symptomer hos pasienter med Crohns sykdom i remisjon: Har kostholdet betydning? Fulltekst i vitenarkiv
• Teigland, Siw Ch.; Valeur, Jørgen & Lerang, Frode (2018). 1 av 10 får magesår i løpet av livet. [Journal]. Allers. Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Sir Tore Midtvedt. Microbial Ecology in Health and Disease. ISSN 0891-060X. 29(1). Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Irritabel tarm - hvor sitter plagene egentlig? Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). I hvalens mage. NGF-nytt. ISSN 0809-6570. 25(3), s. 25–25. Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Eksklusive ekskrementer. NGF-nytt. ISSN 0809-6570. 25(2), s. 33–33. Fulltekst i vitenarkiv
• Johannessen, Kjersti; Berstad, Arnold & Valeur, Jørgen (2018). Jo, du har faktisk dessertmage. [Internet]. www.tv2.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Forsideillustrasjon til Indremedisineren nr. 1 2018. Fulltekst i vitenarkiv
• Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Hausken, Trygve & Gilja, Odd Helge (2018). Nausea in patients with IBS and functional dyspepsia. Fulltekst i vitenarkiv
• Mazzawi, Tarek; Lied, Gülen Arslan; Hov, Johannes Espolin Roksund; Valeur, Jørgen; Sangnes, Dag André & El-Salhy, Magdy [Vis alle 9 forfattere av denne artikkelen] (2018). Effects of faecal microbiota transplantation on gut microenvironment and symptoms in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Bramness, Jørgen Gustav & Valeur, Jørgen (2018). Alkoholassosiert dysbiose? NGF-nytt. ISSN 0809-6570. 25(1), s. 29–29. Fulltekst i vitenarkiv
• Risstad, Hilde & Valeur, Jørgen (2018). Fedmeepidemien - ligger svaret i tarmen? Indremedisineren. ISSN 1891-1617. s. 22–25. Fulltekst i vitenarkiv
• Valeur, Jørgen & Waldum, Helge (2018). Surmaget. NGF-nytt. ISSN 0809-6570. 25(1), s. 42–42. Fulltekst i vitenarkiv
• Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Hausken, Trygve & Gilja, Odd Helge (2018). Nausea in patients with IBS and functional dyspepsia. Neurogastroenterology and Motility. ISSN 1350-1925. 30, s. 126–126. Fulltekst i vitenarkiv
• Mazzawi, Tarek; Lied, Gülen Arslan; Hov, Johannes Espolin Roksund; Valeur, Jørgen; Sangnes, Dag André & El-Salhy, Magdy [Vis alle 9 forfattere av denne artikkelen] (2018). Effects of faecal microbiota transplantation on gut microenvironment and symptoms in patients with irritable bowel syndrome. Neurogastroenterology and Motility. ISSN 1350-1925. 30, s. 178–179. Fulltekst i vitenarkiv
• Juul, Frederik Emil; Garborg, Kjetil Kjeldstad; Bretthauer, Michael; Kalager, Mette; Midtvedt, Tore & Furholm, Siv [Vis alle 17 forfattere av denne artikkelen] (2018). Fecal microbiota transplantation versus antibiotics for primary Clostridium difficile infection - a multicenter, randomized proof-of-concept trial. Fulltekst i vitenarkiv
• Rødelv, Anne Kristin; Lindberg, Fedon & Valeur, Jørgen (2018). Bakterier på ville veier. [Journal]. Fordøyelsen. Fulltekst i vitenarkiv
• Lillestøl, Kristine & Valeur, Jørgen (2018). Kan tarmfloraen føreseie effekt av behandling? [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Medhus, Asle Wilhelm; Skar, Viggo Øystein; Malvik, Stine & Henriksen, Christine [Vis alle 9 forfattere av denne artikkelen] (2018). Tarmfloraendringer hos pasienter med forhøyet alkoholkonsum. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2018). Dessertmage. I Lærum, Ole Didrik (Red.), Verken syk eller frisk. Sunnhet og sykdom er ikke lenger hva de var. Fagbokforlaget. ISSN 9788245024418. s. 46–47. Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Tarmfloraen - kroppens største organ. Fulltekst i vitenarkiv
• Rødahl, Jenny Mina; Svihus, Birger; Sundfør, Tine Mejlbo; eskerud, mari borge & Valeur, Jørgen (2018). Derfor blir du oppblåst. [Journal]. Dagbladet. Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Fordøyelse til besvær. Helsesekretæren. ISSN 0803-5865. s. 11–13. Fulltekst i vitenarkiv
• Benestad, Haakon Breien & Valeur, Jørgen (2018). Har tarmfloraen betydning for utvikling av multippel sklerose? [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Mikrobiota - tarmflora. Fulltekst i vitenarkiv
• Valeur, Jørgen (2018). Alkoholbruk og depresjon: Er tarmfloraen involvert? Fulltekst i vitenarkiv
• Mazzawi, Tarek; Lied, Gülen Arslan; Hov, Johannes Espolin Roksund; Valeur, Jørgen; Sangnes, Dag André & Gilja, Odd Helge [Vis alle 8 forfattere av denne artikkelen] (2018). Correlations between gut microenvironment and symptoms in patients with diarrhea-predominant irritable bowel syndrome. Fulltekst i vitenarkiv
• Juul, Frederik Emil; Skudal, Hilde Kristin; Øines, Mari Nanna; Wiig, Håvard; Rose, Øystein & Seip, Birgitte Karen Berggreen [Vis alle 14 forfattere av denne artikkelen] (2018). Fecal microbiota transplant in primary Clostridium difficile infection - a proof-of-concept trial. Fulltekst i vitenarkiv
• Lillestøl, Kristine; Valeur, Jørgen & Middelthon, Anne-Lise Orvin (2017). "Neurasthenia gastrica" revisited: The gut in Norwegian neurasthenia 1880-1930. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Alterations of gut microbiota composition in patients with chronic alcohol overconsumption. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan & Valeur, Jørgen (2017). Functional food for functional disorders. Microbial Ecology in Health and Disease. ISSN 0891-060X. 28. Fulltekst i vitenarkiv
• Valeur, Jørgen; Småstuen, Milada C; Knudsen, Torunn; Lied, Gülen Arslan & Røseth, Arne (2017). Microbial DNA markers associated with response to a low FODMAP diet in patients with irritable bowel syndrome. Gastroenterology. ISSN 0016-5085. 152(5), s. S-44–S-45. Fulltekst i vitenarkiv
• Valeur, Jørgen & Kleveland, Per Martin (2017). Magemål. NGF-nytt. ISSN 0809-6570. 24(2), s. 47–47. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2017). Is i magen. NGF-nytt. ISSN 0809-6570. 24(3), s. 27–27. Fulltekst i vitenarkiv
• Spilde, Ingrid & Valeur, Jørgen (2017). Bakterieflora fra tarmen ga mus tegn til irritabel tarm og angst. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen; Småstuen, Milada C; Knudsen, Torunn; Lied, Gülen Arslan & Røseth, Arne (2017). Microbial DNA markers associated with response to a low FODMAP diet in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Mazzawi, Tarek; Valeur, Jørgen; Hausken, Trygve; El-Salhy, Magdy; Hatlebakk, Jan Gunnar & Lied, Gülen Arslan (2017). Effect of faecal microbiota transplantation on gut bacterial fermentation products in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Spilde, Ingrid; Valeur, Jørgen & Raa, Jan (2017). Plantekost kan være enda viktigere enn antatt. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Fordøyelse til besvær. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Alterations of gut microbiota composition in patients with chronic alcohol overconsumption. Neurogastroenterology and Motility. ISSN 1350-1925. 29, s. 84–85. Fulltekst i vitenarkiv
• Kvislen, Hanne Solveig; Edin, Julia Døhlen & Valeur, Jørgen (2017). Ikke bare sjarm med tarm. [Journal]. Kamille nr. 7, s. 106-9. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Avføring som terapi. Årbok / Det norske videnskaps-akademi. ISSN 0332-6209. s. 450–451. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Fordøyelse til besvær. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Irritabel tarm-syndrom. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Holbergs Hofmesterinde. NGF-nytt. ISSN 0809-6570. 24(4), s. 58–58. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Forsideillustrasjon til "Ramazzini" 2017;24(3). Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Forsideillustrasjon til "NGF-nytt" 2017;24(4). Fulltekst i vitenarkiv
• Glorvigen, Eva & Valeur, Jørgen (2017). Magen og hjernen snakker sammen. [Journal]. Helsebilag til Hjemmet. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Tarmfloraen, kroppens største organ. Fulltekst i vitenarkiv
• Bernhoft, Aksel; Berstad, Arnold; Eggesbø, Merete Åse; Garborg, Kjetil Kjeldstad; Harstad, Odd Magne & Holst-Jensen, Arne [Vis alle 15 forfattere av denne artikkelen] (2017). Tarmens viktige mikrober. Del III: Kan avføring brukes som behandling mot sykdommer? Forskning.no. ISSN 1891-635X. Fulltekst i vitenarkiv
• Bernhoft, Aksel; Berstad, Arnold; Eggesbø, Merete Åse; Garborg, Kjetil Kjeldstad; Harstad, Odd Magne & Holst-Jensen, Arne [Vis alle 15 forfattere av denne artikkelen] (2017). Tarmens viktige mikrober. Del I: Tarmens viktige mikrober har stor betydning for helsen. Forskning.no. ISSN 1891-635X. Fulltekst i vitenarkiv
• Bernhoft, Aksel; Berstad, Arnold; Eggesbø, Merete Åse; Garborg, Kjetil Kjeldstad; Harstad, Odd Magne & Holst-Jensen, Arne [Vis alle 15 forfattere av denne artikkelen] (2017). Tarmens viktige mikrober. Del II: Disse sykdommene kan kobles til det som bor i tarmen. Forskning.no. ISSN 1891-635X. Fulltekst i vitenarkiv
• Ulveseth, Silje; Valeur, Jørgen & Hausken, Trygve (2017). Hva er normal avføring? [Internet]. Lommelegen.no. Fulltekst i vitenarkiv
• Kielland, Ingrid Røise; Stenvik, Bår; Øien, Torbjørn; Eggesbø, Merete Åse; Valeur, Jørgen & Birkeland, Stein-Erik [Vis alle 16 forfattere av denne artikkelen] (2017). Bakteriebomben. [Journal]. D2 - Dagens Næringsliv. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Tarmfloraen - kroppens største organ. Fulltekst i vitenarkiv
• Bernhoft, Aksel; Midtvedt, Tore; Eggesbø, Merete Åse; Aas, Anne-Marie; Berstad, Arnold & Harstad, Odd Magne [Vis alle 15 forfattere av denne artikkelen] (2017). Tarmens viktige mikrober - hvordan mater vi dem, og hva gjør de med oss? Årbok 2016 Det Norske Videnskaps-Akademi. Novus Forlag. ISSN 9788270998883. s. 438–453. Fulltekst i vitenarkiv
• Ulveseth, Silje; Valeur, Jørgen; Brelin, Petter & Hausken, Trygve (2017). Symptomer på sykdom i magen eller tarmen. [Internet]. Lommelegen.no. Fulltekst i vitenarkiv
• Pedersen, Pia; Valeur, Jørgen & Bergem, Anne Kristine (2017). Episode 81. Jørgen Valeur. [Radio]. Pia og psyken (podkast; http://www.piaogpsyken.com). Fulltekst i vitenarkiv
• Mazzawi, Tarek; Valeur, Jørgen; Hausken, Trygve; El-Salhy, Magdy; Hatlebakk, Jan Gunnar & Lied, Gülen Arslan (2017). Effect of faecal microbiota transplantation on gut bacterial fermentation products in patients with irritable bowel syndrome. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 5(5S), s. A563–A564. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Chronic alcohol overconsumption may alter composition of gut microbiota. Fulltekst i vitenarkiv
• Valeur, Jørgen (2017). Analyse og funksjon av kortkjedede fettsyrer (Short-Chain Fatty Acids; SCFA). Fulltekst i vitenarkiv
• Tunstrøm, Stine; Hausken, Trygve & Valeur, Jørgen (2016). Om "stressmage" (funksjonell dyspepsi). [Internet]. kk.no. Fulltekst i vitenarkiv
• Andreassen, Katrine; Brelin, Petter & Valeur, Jørgen (2016). Noen typer diaré er det viktig at du går til legen med. [Internet]. Klikk.no. Fulltekst i vitenarkiv
• Valeur, Jørgen; Undseth, Ragnhild Marie & Berstad, Arnold (2016). "Gährungsdyspepsie" revisited. American Journal of Gastroenterology. ISSN 0002-9270. 111(1), s. 145–147. doi: 10.1038/ajg.2015.361. Fulltekst i vitenarkiv
• Spilde, Ingrid & Valeur, Jørgen (2016). Mindre følsomme nerver hos de med irritabel tarm. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Skar, Viggo Øystein; Bramness, Jørgen Gustav; Medhus, Asle Wilhelm; Tollisen, Anita & Valeur, Jørgen (2016). Påvirker alkohol tarmens mikroflora? En retrospektiv studie av 719 13C-D-Xylose pusteprøver. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Fordøyelse til besvær. I Storla, Dag Gustav Gundersen (Red.), Diffusitas. Når legen står fast. Fagbokforlaget. ISSN 9788245018721. s. 155–167. Fulltekst i vitenarkiv
• Valeur, Jørgen; Erchinger, Friedemann Georg & Berstad, Arnold (2016). Diagnostikk av gjæringsdyspepsi - før og nå. NGF-nytt. ISSN 0809-6570. 23(3), s. 36–37. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan & Valeur, Jørgen (2016). Lett fordøyelig mat gir "hedonisk" sult og bidrar til overvekt. Helsemagasinet VOF. 7(1), s. 64–68. Fulltekst i vitenarkiv
• Hustoft, Tonje; Hausken, Trygve; Ystad, Synne Otteraaen; Valeur, Jørgen; Brokstad, Karl Albert & Hatlebakk, Jan Gunnar [Vis alle 7 forfattere av denne artikkelen] (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Mikrobiota og fermentering i tarm. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Tarmfloraen - kroppens største organ. Fulltekst i vitenarkiv
• Valeur, Jørgen; Røseth, Arne; Knudsen, Torunn; Malmstrøm, Gunn Helen; Fiennes, Jennifer Twisleton & Midtvedt, Tore [Vis alle 7 forfattere av denne artikkelen] (2016). Low FODMAP diet in IBS: Influence on fecal fermentation. Fulltekst i vitenarkiv
• Hustoft, Tonje; Hausken, Trygve; Ystad, Synne Otteraaen; Valeur, Jørgen; Brokstad, Karl Albert & Hatlebakk, Jan Gunnar [Vis alle 7 forfattere av denne artikkelen] (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial. Fulltekst i vitenarkiv
• Dahl, Cecilie; Stigum, Hein; Valeur, Jørgen; Iszatt, Nina; Lenters, Virissa & Mandal, Siddhartha [Vis alle 9 forfattere av denne artikkelen] (2016). Preterm infants have distinct microbiomes, not explained by mode of delivery, less breastfeeding, or antibiotic exposure. Fulltekst i vitenarkiv
• Brackmann, Stephan; Valeur, Jørgen; Raa, Jan & Berstad, Arnold (2016). Sauerkraut - mat, medisin og konserveringsmiddel i over 2000 år. NGF-nytt. ISSN 0809-6570. 23(4), s. 46–47. Fulltekst i vitenarkiv
• Bergersen, Ida H.; Valeur, Jørgen & Sauar, Jostein (2016). IBS: Dette er irritabel tarm-syndrom. [Internet]. Lommelegen.no. Fulltekst i vitenarkiv
• Spilde, Ingrid; Valeur, Jørgen & Hausken, Trygve (2016). Frykter probiotika kan skade. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2016). Dessertmage. I Hem, Erlend (Red.), Verken syk eller frisk. Sunnhet og sykdom er ikke lenger hva de var. Tidsskriftet. Den norske legeforening. ISSN 9788280701190. Fulltekst i vitenarkiv
• Rashidi, Kaveh & Valeur, Jørgen (2016). Fecestransplantasjon mot tarminfeksjon? [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). Fulltekst i vitenarkiv
• Malmstrøm, Gunn Helen; Fiennes, Jennifer Twisleton & Valeur, Jørgen (2016). Etablering av metode for måling av kortkjedede fettsyrer i feces. Fulltekst i vitenarkiv
• Tunstrøm, Stine; Barexstein, Brynjulf & Valeur, Jørgen (2016). Derfor rumler magen når du er sulten. [Internet]. kk.no. Fulltekst i vitenarkiv
• Spets, Kari; Nilsen, Annette & Valeur, Jørgen (2016). Matbabyen tar av! [Journal]. VG. Fulltekst i vitenarkiv
• Spilde, Ingrid; El-Salhy, Magdy; Midtvedt, Tore & Valeur, Jørgen (2016). Irritabel tarm – fra psykisk til fysisk. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Dr.med. = PhD? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). IBS och kost. Fulltekst i vitenarkiv
• Spilde, Ingrid & Valeur, Jørgen (2016). Professor advarer mot antibiotika for barn. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Spilde, Ingrid & Valeur, Jørgen (2016). Hva slags bakterier skal vi ha i tarmen? [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen; Landfald, Bjarne; Berstad, Arnold & Raa, Jan (2016). Trimethylamine N-oxide in seafood. Rotten or forgotten? Journal of the American College of Cardiology. ISSN 0735-1097. 68(25), s. 2916–2917. Fulltekst i vitenarkiv
• Vara, Ellen Johanne; Valeur, Jørgen; Hausken, Trygve & Lied, Gülen Arslan (2016). High levels of serum total IgE-antibodies are not related to intestinal and extra-intestinal symptom severity in irritable bowel syndrome. Neurogastroenterology and Motility. ISSN 1350-1925. 28, s. 63–63. Fulltekst i vitenarkiv
• Valeur, Jørgen; Røseth, Arne; Knudsen, Torunn; Malmstrøm, Gunn Helen; Fiennes, Jennifer Twisleton & Midtvedt, Tore [Vis alle 7 forfattere av denne artikkelen] (2016). Dietary FODMAP restriction alters faecal fermentation in patients with IBS. Neurogastroenterology and Motility. ISSN 1350-1925. 28, s. 25–25. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2016). Gut gateway to generalized pain. Scandinavian Journal of Pain. ISSN 1877-8860. 13, s. 164–165. doi: 10.1016/j.sjpain.2016.06.001. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan; Midtvedt, Tore & Valeur, Jørgen (2016). Melkesyrebakterier - gjøkunger i tarmen? NGF-nytt. ISSN 0809-6570. 23(1), s. 51–54. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Forsideillustrasjon til "NGF-nytt" 2016;23(4). Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Re: Bare psykisk. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 136(9), s. 783–783. doi: 10.4045/tidsskr.16.0381. Fulltekst i vitenarkiv
• Valeur, Jørgen; Røseth, Arne; Knudsen, Torunn; Malmstrøm, Gunn Helen; Fiennes, Jennifer Twisleton & Midtvedt, Tore [Vis alle 7 forfattere av denne artikkelen] (2016). Dietary FODMAP restriction alters faecal fermentation in patients with IBS. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Avføring som terapi. Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Tarmflora. Fulltekst i vitenarkiv
• Hustoft, Tonje; Hausken, Trygve; Ystad, Synne Otteraaen; Valeur, Jørgen; Brokstad, Karl Albert & Hatlebakk, Jan Gunnar [Vis alle 7 forfattere av denne artikkelen] (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial. Fulltekst i vitenarkiv
• Tvedten, Hilde Marie; Valeur, Jørgen; Goll, Rasmus; Johnsen, Peter Holger; Hov, Johannes Espolin Roksund & Hausken, Trygve (2016). En skikkelig drittpakke. [Journal]. Dagbladet (Magasinet). Fulltekst i vitenarkiv
• Valeur, Jørgen (2016). Mikrobiota - tarmflora. Fulltekst i vitenarkiv
• Hustoft, Tonje; Hausken, Trygve; Ystad, Synne Otteraaen; Valeur, Jørgen; Brokstad, Karl Albert & Hatlebakk, Jan Gunnar [Vis alle 7 forfattere av denne artikkelen] (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 4, s. A101–A101. Fulltekst i vitenarkiv
• Valeur, Jørgen & Midtvedt, Tore (2015). Probiotika mot nyrestein? [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). doi: 10.4045/tidsskr.15.0415. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Diet and irritable bowel syndrome: a microbial perspective. Fulltekst i vitenarkiv
• Ulveseth, Silje & Valeur, Jørgen (2015). Derfor får du akutt diaré. [Internet]. Lommelegen.no. Fulltekst i vitenarkiv
• Bjørnskau, Hilde; Valeur, Jørgen & Nordstrand, Berit (2015). Nå skrives livsstilsbøkene av eksperter. [Internet]. nrk.no. Fulltekst i vitenarkiv
• Ribe, Torhild; Larsen, Annemor; Valeur, Jørgen & Ågotnes, Cecilie Hauge (2015). FODMAP fikk orden på mageproblemene. [Internet]. Vektklubb.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Funksjonelle lidelser i øvre GI-traktus. Fulltekst i vitenarkiv
• Raa, Jan; Berstad, Arnold & Valeur, Jørgen (2015). Forstyrrelser i tarmkanalens redoks-biologi - en oversett sykdomsmekanisme? NGF-nytt. ISSN 0809-6570. 22(4), s. 32–36. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Forsideillustrasjon til "NGF-nytt" 2015;22(4). Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2015). IBS - slik vi ser det. Fulltekst i vitenarkiv
• Sauar, Jostein; Valeur, Jørgen; Berstad, Arnold; Lundin, Knut E A; Engstrand, Lars & Farup, Per Grønaas (2015). Det første nasjonale møtet om funksjonelle mage-tarm-lidelser (FGID) 18. mars 2015. NGF-nytt. ISSN 0809-6570. 22(2), s. 32–33. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Editorial: We all need friends. Microbial Ecology in Health and Disease. ISSN 0891-060X. 26. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae & Valeur, Jørgen (2015). "Alcoholic Bowel Syndrome" (ABS). Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Tarmfloraens betydning. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Trøseid, Marius; Berstad, Arnold & Valeur, Jørgen (2015). Markers of intestinal injury and endotoxemia in patients with irritable bowel syndrome. Neurogastroenterology and Motility. ISSN 1350-1925. 27, s. 105–105. doi: 10.1111/nmo.12598. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan & Valeur, Jørgen (2015). Hedonisk hunger, fedme og bearbeidet mat. NGF-nytt. ISSN 0809-6570. 22(3), s. 64–66. Fulltekst i vitenarkiv
• Steinsvik, Elisabeth K. & Valeur, Jørgen (2015). En mage av stein. NGF-nytt. ISSN 0809-6570. 22(3), s. 43–43. Fulltekst i vitenarkiv
• Lindahl, Lena & Valeur, Jørgen (2015). Vondt i magen? [Journal]. Boots-magasinet (Helse & velvære). Fulltekst i vitenarkiv
• Berstad, Arnold; Valeur, Jørgen; Raa, Jan & Midtvedt, Tore (2015). Beskyttende bakterier. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Tarmfloraen - kroppens største organ. Nyvinninger i medisinen innen dette feltet de siste årene. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Irritabel tarm-syndrom (IBS). Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Fordøyelse til besvær. Utposten. ISSN 0800-5680. 44(3), s. 18–23. Fulltekst i vitenarkiv
• Valeur, Jørgen; Puaschitz, Nathalie Genevieve; Berstad, Arnold & Midtvedt, Tore (2015). The effect of oatmeal porridge on gut microbial functions. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Mikrobesamfunnet i tarmen - flora eller fauna? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 135(12/13), s. 1154–1154. doi: 10.4045/tidsskr.15.0393. Fulltekst i vitenarkiv
• Korneliussen, Rannveig; Valeur, Jørgen & Hausken, Trygve (2015). Magefølelsen. [Journal]. Dagbladet (Magasinet). Fulltekst i vitenarkiv
• Lamøy, Berith Eva & Valeur, Jørgen (2015). Mangelfull dokumentasjon av effekt av aloe vera mot mageproblemer. [Journal]. Norsk Ukeblad. Fulltekst i vitenarkiv
• Ulveseth, Silje & Valeur, Jørgen (2015). Helserådet som bare gjør vondt verre. [Internet]. Lommelegen.no. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Trøseid, Marius; Berstad, Arnold & Valeur, Jørgen (2015). Markers of intestinal injury and endotoxemia in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Ulveseth, Silje & Valeur, Jørgen (2015). Diaré? Styr unna denne maten. [Internet]. Lommelegen.no. Fulltekst i vitenarkiv
• Ulveseth, Silje; Hausken, Trygve & Valeur, Jørgen (2015). Forstoppelse: Dette hjelper! [Internet]. Lommelegen.no. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2014). Skal FODMAP-dietten tilpasses den enkelte pasient? Fordøyelsen. ISSN 0808-4297. s. 28–30. Fulltekst i vitenarkiv
• Berstad, Arnold; Valeur, Jørgen & Sauar, Jostein (2014). Pasienter med irritabel tarm: Meld dere inn i Landsforeningen mot fordøyelsessykdommer! Fordøyelsen. ISSN 0808-4297. s. 26–26. Fulltekst i vitenarkiv
• Engdahl, Bjørg; Valeur, Jørgen; Sauar, Jostein; Knudsen, Torunn; Høgestøl, Tone Cecilie & Schatten, Arne [Vis alle 7 forfattere av denne artikkelen] (2014). Hjelp mot irriterte tarmer. [Journal]. Bedre helse. Fulltekst i vitenarkiv
• Sanderød, Anlaug & Valeur, Jørgen (2014). Matintoleranse: Blir du sunnere uten gluten? [Internet]. Klikk.no. Fulltekst i vitenarkiv
• Haugen, Trine B. & Valeur, Jørgen (2014). Tarmbakterier og immunceller samarbeider. [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). doi: 10.4045/tidsskr.14.1125. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2014). Sykdommer i fordøyelseskanalen, Psykiske reaksjoner ved somatisk sykdom. Cappelen Damm Akademisk. ISSN 9788202418786. s. 496–503. Fulltekst i vitenarkiv
• Valeur, Jørgen (2014). Gut microbiota - of relevance for the dietitian? Fulltekst i vitenarkiv
• Valeur, Jørgen & Midtvedt, Tore (2014). Fecestransplantasjon - ny vidundermedisin? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 134(23/24), s. 2233–2233. doi: 10.4045/tidsskr.14.1261. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Berstad, Arnold; Klow, Nils-Einar & Valeur, Jørgen (2014). FODMAP-intoleranse ved IBS: En MRI-studie. Fulltekst i vitenarkiv
• Tunstrøm, Stine & Valeur, Jørgen (2014). Sliter du med luftsmerter og urolig mage? [Internet]. kk.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2014). Forsideillustrasjon til "NGF-nytt" 2014;21(4). Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan & Valeur, Jørgen (2014). Indol - duften av et sunt indre jordsmonn. NGF-nytt. ISSN 0809-6570. 21(4), s. 36–37. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2014). Skal FODMAP-dietten tilpasses den enkelte pasient? NGF-nytt. ISSN 0809-6570. 21(1), s. 20–21. Fulltekst i vitenarkiv
• Berstad, Arnold; Raa, Jan & Valeur, Jørgen (2014). Tryptofan: "essensiell" også i IBS-patogenesen? NGF-nytt. ISSN 0809-6570. 21(2), s. 12–14. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Jakobsdottir, Greta; Nyman, Margareta; Berstad, Arnold & Valeur, Jørgen (2014). Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired microbial fermentation in patients with irritable bowel syndrome. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 2, s. A556–A556. Fulltekst i vitenarkiv
• Valeur, Jørgen; Knudsen, Torunn; Mellin-Olsen, Tonje & Røseth, Arne (2014). Influence of a low-FODMAP diet on symptoms and gut microbiota in patients with irritable bowel syndrome. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 2, s. A556–A556. Fulltekst i vitenarkiv
• Valeur, Jørgen; Knudsen, Torunn; Mellin-Olsen, Tonje & Røseth, Arne (2014). Influence of a low-FODMAP diet on symptoms and gut microbiota in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Valeur, Jørgen (2014). Tarmfloraens betydning. Fulltekst i vitenarkiv
• Hanger, Mari Rian; Berstad, Arnold; Valeur, Jørgen; Helland, Ingrid & Owe, Jone Furulund (2014). - Ubalanse i tarmen kan føre til kronisk tretthet. [Journal]. Dagens Medisin. Fulltekst i vitenarkiv
• Ulveseth, Silje & Valeur, Jørgen (2014). Er det farlig å holde seg? [Internet]. kk.no. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Jakobsdottir, Greta; Nyman, Margareta; Berstad, Arnold & Valeur, Jørgen (2014). Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired microbial fermentation in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Lein, Marthe & Valeur, Jørgen (2014). Irritabel tykktarm, kostråd, FODMAP. [Internet]. Norsk Helseinformatikk (nhi.no). Fulltekst i vitenarkiv
• Valeur, Jørgen (2014). Irritabel tarm-syndrom. Fulltekst i vitenarkiv
• Spilde, Ingrid; Undseth, Ragnhild Marie; Valeur, Jørgen & Farup, Per Grønaas (2014). Første synlige bevis for irritabel tarm. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Nordahl, Marianne & Valeur, Jørgen (2014). Flere fedmebakterier i nordboeres mager? [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Berstad, Arnold; Hauso, Olav & Valeur, Jørgen (2014). Intestinal staphylococcal small colony variants: a cause of medically unexplained physical symptoms? Microbial Ecology in Health and Disease. ISSN 0891-060X. 25. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2014). Komorbiditet ved opplevd matintoleranse. BestPractice Gastroenterologi. ISSN 1903-6590. s. 7–9. Fulltekst i vitenarkiv
• Valeur, Jørgen (2013). Irritabel tarm og funksjonell dyspepsi. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2013). Guanylat syklase C-stimulering - endelig noe som hjelper mot irritabel tarm? NGF-nytt. ISSN 0809-6570. 20(1), s. 33–33. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2013). Irritabel tarm-syndrom - et mikrobielt perspektiv. 133(21), s. 2276–2278. doi: 10.4045/tidsskr.13.1185. Fulltekst i vitenarkiv
• Spilde, Ingrid; Valeur, Jørgen; Berstad, Arnold & Hjelmesæth, Jøran (2013). Fet og forgiftet. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Spilde, Ingrid & Valeur, Jørgen (2013). Smittsom slankhet. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen (2013). En flora av muligheter og utfordringer. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 133(23-24), s. 2531–2531. Fulltekst i vitenarkiv
• Lærum, Ole Didrik; Berstad, Arnold & Valeur, Jørgen (2013). Lytt til barna // Dessertmage. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 133(23-24), s. 12536–12537. Fulltekst i vitenarkiv
• Spilde, Ingrid; Valeur, Jørgen; Berstad, Arnold; Tangen, Tone & Henriksen, Christine (2013). Når sunn mat gjør deg dårlig. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen & Julsrud, Joar (2013). Vomiting: a physiological response to acidosis? Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 48(9), s. 1103–1104. doi: 10.3109/00365521.2013.825926. Fulltekst i vitenarkiv
• Bråthen, Trine & Valeur, Jørgen (2013). Mageproblemer på fly. [Radio]. NRK Østlandssendingen. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2013). "Lekk tarm": En årsak til fibromyalgi? Fibromyalgibladet. s. 9–10. Fulltekst i vitenarkiv
• Fantoft, Sissel & Valeur, Jørgen (2013). En av ti sliter med dårlig mage. [Journal]. AstmaAllergi. Fulltekst i vitenarkiv
• Valeur, Jørgen (2013). Flymage. NGF-nytt. ISSN 0809-6570. s. 28–28. Fulltekst i vitenarkiv
• Spilde, Ingrid & Valeur, Jørgen (2013). Har du flymage? [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Teigland, Siw Ch. & Valeur, Jørgen (2013). Maten som hjelper mot irritabel tarm. [Journal]. Allers nr 24. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2013). "Lekk tarm": Fleip eller fakta? NGF-nytt. ISSN 0809-6570. 20(4), s. 32–34. Fulltekst i vitenarkiv
• Valeur, Jørgen (2013). Forsideillustrasjon til "NGF-nytt" 2013;20(4). Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2013). Immunologi ved uforklart, selvrapportert matoverfølsomhet. Indremedisineren. ISSN 1891-1617. s. 40–41. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Berstad, Arnold & Valeur, Jørgen (2013). FODMAP-intolerance in IBS: Visualization by Magnetic Resonance Imaging. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 1, s. A110–A110. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Berstad, Arnold & Valeur, Jørgen (2013). FODMAP-intolerance in IBS: Visualization by Magnetic Resonance Imaging. Fulltekst i vitenarkiv
• Valeur, Jørgen (2013). Tore forteller om tarmfloraen. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 133(18), s. 1961–1961. doi: 10.4045/tidsskr.13.0917. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2012). Fibromyalgi og kronisk tretthetssyndrom hos pasienter med matoverfølsomhet. Fulltekst i vitenarkiv
• Valeur, Jørgen (2012). Irritabel tarm-syndrom: Er det karbohydratintoleranse? Fulltekst i vitenarkiv
• Berstad, Arnold; Undseth, Ragnhild M; Lind, Ragna & Valeur, Jørgen (2012). Comorbidity in patients with perceived food hypersensitivity. Gut. ISSN 0017-5749. 61, s. A337–A337. Fulltekst i vitenarkiv
• Berstad, Arnold; Undseth, Ragnhild M; Lind, Ragna & Valeur, Jørgen (2012). Comorbidity in patients with perceived food hypersensitivity. Fulltekst i vitenarkiv
• Valeur, Jørgen (2012). Matoverfølsomhet ved irritabel tarm. Fulltekst i vitenarkiv
• Berstad, Arnold; Morken, Mette Helvik; Lied, Gülen Arsland; Lind, Ragna; Hjartholm, Aud-Sissel & Valeur, Jørgen (2012). Fecal fat excretion in irritable bowel syndrome. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 47(8-9), s. 1120–1121. doi: 10.3109/00365521.2012.696683. Fulltekst i vitenarkiv
• Valeur, Jørgen (2012). Tankevekkende om tarmfloraen. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 132, s. 2657–2657. Fulltekst i vitenarkiv
• Spilde, Ingrid; Valeur, Jørgen; Berstad, Arnold & Malterud, Kirsti (2012). Matintoleranse knyttes til mange plager. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Viste, Kristin & Valeur, Jørgen (2012). Tarmflora påvirker metabolismen. [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2012). "MikrObesitas" - og dens mulige behandling med havregrynsgrøt og kanel. NGF-nytt. ISSN 0809-6570. 19(4), s. 10–12. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2012). Laktuloseprovokasjon: Nyttig undersøkelse ved irritabel tarm-syndrom? NGF-nytt. ISSN 0809-6570. 19(4), s. 13–14. Fulltekst i vitenarkiv
• Valeur, Jørgen (2012). Forsideillustrasjon til "NGF-nytt" 2012;19(4). Fulltekst i vitenarkiv
• Valeur, Jørgen (2012). Forsideillustrasjon til "Metodebok i akutt indremedisin 2012. 6. utgave". Fulltekst i vitenarkiv
• Spilde, Ingrid & Valeur, Jørgen (2012). Hvorfor lå romerne når de spiste? [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Nordlund, Hilde & Valeur, Jørgen (2012). Slik lurer magen deg. [Journal]. Dagbladet. Fulltekst i vitenarkiv
• Valeur, Jørgen (2012). Funksjonelle mage-tarm-lidelser. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2012). Det er ikke allergi alt som romler! Men hva er det da? Helserådet. ISSN 0806-7457. 20, s. 17–18. Fulltekst i vitenarkiv
• Beyer-Olsen, Audun; Berstad, Arnold; Valeur, Jørgen & Drevon, Christian A (2011). Ny forskning: Derfor takker du ja til dessert. [Internet]. VG.no. Fulltekst i vitenarkiv
• Spilde, Ingrid; Berstad, Arnold & Valeur, Jørgen (2011). Derfor har du plass til dessert. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Øyen, Ragnhild Sleire & Valeur, Jørgen (2011). Dessertmage. [Radio]. NRK P1 (Norgesglasset). Fulltekst i vitenarkiv
• Nielsen, Marie Ravn; Berstad, Arnold & Valeur, Jørgen (2011). Derfor kan du altid spise dessert. [Internet]. dr.dk. Fulltekst i vitenarkiv
• Mjør, Kjersti; Berstad, Arnold & Valeur, Jørgen (2011). Derfor har du plass i dessertmagen. [Internet]. BT.no. Fulltekst i vitenarkiv
• Valeur, Jørgen & Spilde, Ingrid (2011). Tenker nytt om irritabel tarm. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen & Rossevik, Lena Viola (2011). Følelser og fordøyelse - et komplisert samspill. [Journal]. Mat og helse. Fulltekst i vitenarkiv
• Spilde, Ingrid; Valeur, Jørgen; Berstad, Arnold; Midtvedt, Tore & Bruusgaard, Dag (2011). Forgiftet innenfra. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Berstad, Arnold & Valeur, Jørgen (2011). Mageplager ved fibromyalgi: Et tarmfloraproblem? Fibromyalgibladet. s. 6–11. Fulltekst i vitenarkiv
• Valeur, Jørgen (2010). Colon: En viktig symptomgenerator. Fulltekst i vitenarkiv
• Valeur, Jørgen (2010). Tykktarmens funksjon. Fulltekst i vitenarkiv
• Valeur, Jørgen (2010). IBS: En forstyrrelse i tykktarmens funksjon. Fulltekst i vitenarkiv
• Feiring, E & Valeur, Jørgen (2010). Forklarer uforklart matoverfølsomhet? [Journal]. Tidsskrift for Den norske legeforening (Tidsskriftet). Fulltekst i vitenarkiv
• Valeur, Jørgen; Lillestøl, Kristine; Morken, Mette Helvik; Norin, E; Midtvedt, T & Berstad, Arnold (2010). Symptoms and rectal fermentation products in response to lactulose challenge in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Lind, Ragna; Lied, Gülen Arsland; Lillestøl, Kristine; Valeur, Jørgen & Berstad, Arnold (2010). Do psychological factors explain symptom severity in patients with subjective food hypersensitivity? Fulltekst i vitenarkiv
• Pettersen, Petter Morten & Valeur, Jørgen (2010). Frukt og grønt erter magen. [Journal]. Dagens Medisin. Fulltekst i vitenarkiv
• Lied, Gülen Arsland; Lillestøl, Kristine; Valeur, Jørgen & Berstad, Arnold (2010). Potential role of B-cell activating factor (BAFF) in non-IgE-mediated hypersensitivity reactions to food. Fulltekst i vitenarkiv
• Sandvig, Helene & Valeur, Jørgen (2010). Slik sjekker du avføringen din. [Internet]. Puls, NRK. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2010). The colon is a digestive organ! Advances in Physiology Education. ISSN 1043-4046. 34(3), s. 162–162. doi: 10.1152/advan.00063.2010. Fulltekst i vitenarkiv
• Sandvig, Helene & Valeur, Jørgen (2010). Avføringen sladrer om helsa di. [Internet]. Puls, NRK. Fulltekst i vitenarkiv
• Valeur, Jørgen; Norin, Elisabeth; Midtvedt, Tore & Berstad, Arnold (2010). Assessment of microbial fermentation products in fecal samples. Neurogastroenterology and Motility. ISSN 1350-1925. 22, s. 1147–1147. doi: 10.1111/j.1365-2982.2010.01534.x. Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Norin, Elisabeth; Midtvedt, Tore & Berstad, Arnold (2010). Unexplained, self-reported food hypersensitivity: A fermentation problem? Neurogastroenterology and Motility. ISSN 1350-1925. 22, s. 79–80. Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Norin, Elisabeth; Midtvedt, Tore & Berstad, Arnold (2010). Unexplained, self-reported food hypersensitivity: A fermentation problem? Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2010). "Samlivsproblemer" i tarmen - en oversett sykdomsmekanisme? Fordøyelsen. ISSN 0808-4297. s. 21–22. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2010). Colonic fermentation: a neglected topic in human physiology education. Advances in Physiology Education. ISSN 1043-4046. 34(1), s. 22–22. doi: 10.1152/advan.00103.2009. Fulltekst i vitenarkiv
• Holmemo, Agnete DQ & Valeur, Jørgen (2010). Inspeksjon av avføring. [Radio]. Norgesglasset, NRK P1. Fulltekst i vitenarkiv
• Leine, Ingunn Saltbones & Valeur, Jørgen (2010). Sjekk helsetilstanden din i toalettskålen. [Internet]. VG. Fulltekst i vitenarkiv
• Valeur, Jørgen & Andreassen, Kim (2009). Keiserlig magetrøbbel? [Internet]. Levende historie. Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Games, Turbo Tape & S12, Galleri og Verksted (2009). Ernæringsopplevelsen. Fulltekst i vitenarkiv
• Lied, Gülen Arsland; Lillestøl, Kristine; Valeur, Jørgen & Berstad, Arnold (2009). Potential role of B-cell activating factor in non-IgE-mediated hypersensitivity reactions to food. Fulltekst i vitenarkiv
• Lillestøl, Kristine; Helgeland, Lars Inge; Florvaag, Erik; Lied, Gülen Arsland; Lind, Ragna & Valeur, Jørgen [Vis alle 7 forfattere av denne artikkelen] (2009). Indications of "atopic bowel" in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2009). Tykktarmens bakterieflora - "den siste villmark". Gastroskopet. ISSN 1890-4122. 22(3), s. 7–9. Fulltekst i vitenarkiv
• Valeur, Jørgen; Lillestøl, Kristine; Morken, Mette Helvik; Norin, E; Midtvedt, T & Berstad, Arnold (2009). Symptoms and rectal fermentation products in response to lactulose challenge in patients with irritable bowel syndrome. Neurogastroenterology and Motility. ISSN 1350-1925. 21, s. 83–83. Fulltekst i vitenarkiv
• Lillestøl, Kristine; Valeur, Jørgen; Helgeland, Lars Inge; Florvaag, Erik; Lied, Gülen Arsland & Lind, Ragna [Vis alle 7 forfattere av denne artikkelen] (2009). Indications of `atopic bowel` in patients with irritable bowel syndrome (IBS). Neurogastroenterology and Motility. ISSN 1350-1925. 21, s. 7–7. Fulltekst i vitenarkiv
• Valeur, Jørgen & Andreassen, Kim (2009). Napoleon med sin mage. [Internet]. På høyden. Fulltekst i vitenarkiv
• Valeur, Jørgen & Leine, Ingunn Saltbones (2009). Innføring i avføring. [Journal]. Verdens Gang. Fulltekst i vitenarkiv
• Valeur, Jørgen & Andreassen, Kim (2009). Napoleon med sin mage. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen & Sørdal, Gøril Grov (2009). Napoleansk mageknip? [Radio]. Norgesglasset, NRK P1. Fulltekst i vitenarkiv
• Valeur, Jørgen (2009). Colonic contents, particularly various gases and short-chain fatty acids, play an important role in the generation of IBS symptoms and could be useful therapeutic targets. Fulltekst i vitenarkiv
• Lillestøl, Kristine; Helgeland, Lars Inge; Florvaag, Erik; Lied, Gülen Arsland; Lind, Ragna & Valeur, Jørgen [Vis alle 7 forfattere av denne artikkelen] (2009). Indications of "atopic bowel" in patients with irritable bowel syndrome. Gut. ISSN 0017-5749. 58, s. A20–A20. Fulltekst i vitenarkiv
• Lied, Gülen Arsland; Lillestøl, Kristine; Valeur, Jørgen & Berstad, Arnold (2009). Potential role of B-cell activating factor in non-IgE-mediated hypersensitivity reactions to food. Gut. ISSN 0017-5749. 58, s. A116–A116. Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Norin, E; Midtvedt, T & Berstad, Arnold (2009). Ingestion of lactulose replicates habitual symptoms in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Lillestøl, Kristine; Valeur, Jørgen; Helgeland, Lars Inge; Florvaag, Erik; Lied, Gülen Arsland & Lind, Ragna [Vis alle 7 forfattere av denne artikkelen] (2009). Indications of `atopic bowel` in patients with irritable bowel syndrome (IBS). Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Norin, E; Midtvedt, T & Berstad, Arnold (2009). Karbohydratintoleranse ved IBS. Fulltekst i vitenarkiv
• Valeur, Jørgen; Helle, Karen Blaauw & Berstad, Arnold (2009). A role for chromogranin A in functional gastrointestinal disorders? Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Norin, E.; Midtvedt, T. & Berstad, Arnold (2009). Irritable bowel syndrome - an enterometabolic disorder? Fulltekst i vitenarkiv
• Andreassen, Kim; Valeur, Jørgen & Morken, Mette Helvik (2009). Fordøyelse er en fornøyelse. [Internet]. På Høyden. Fulltekst i vitenarkiv
• Matre, Elisabeth Langeland; Valeur, Jørgen & Morken, Mette Helvik (2009). Lettfordøyelig informasjon. [Journal]. Bergens Tidende. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2009). "Fem om dagen" - tøft for magen? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 129(22), s. 2388–2389. doi: 10.4045/tidsskr.09.1246. Fulltekst i vitenarkiv
• Valeur, Jørgen (2009). Napoleons mage. 129(2), s. 122–123. doi: 10.4045/tidsskr.09.35813. Fulltekst i vitenarkiv
• Valeur, Jørgen; Øines, Eliann; Morken, Mette Helvik; Lillestøl, Kristine; Lind, Ragna & Vaali, Kirsi Kaarina [Vis alle 10 forfattere av denne artikkelen] (2009). Neuroendocrine biomarkers of symptomatic carbohydrate malabsorption. Fulltekst i vitenarkiv
• Valeur, Jørgen; Lappalainen, Jani; Rita, Hannu; Lin, Aung Htun; Kovanen, Petri T. & Berstad, Arnold [Vis alle 8 forfattere av denne artikkelen] (2009). Jejunal dysmotility in a food allergy mouse model. Fulltekst i vitenarkiv
• Valeur, Jørgen & Andreassen, Kim (2009). Napoleon med sin mage. [Journal]. Hubro. Magasin for Universitetet i Bergen. Fulltekst i vitenarkiv
• Valeur, Jørgen; Morken, Mette Helvik; Nordin, Ellinor; Midtvedt, Tore & Berstad, Arnold (2009). Irritable bowel syndrome - an enterometabolic disorder? Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44, s. 28–28. Fulltekst i vitenarkiv
• Valeur, Jørgen; Lillestøl, Kristine; Morken, Mette Helvik; Norin, E; Midtvedt, T & Berstad, Arnold (2009). Symptoms and rectal fermentation products in response to lactulose challenge in patients with irritable bowel syndrome. Fulltekst i vitenarkiv
• Valeur, Jørgen & Gjengedal, Kjerstin (2008). Forsker på magefølelse. [Journal]. Dagens Næringsliv. Fulltekst i vitenarkiv
• Valeur, Jørgen & Nilsen, Lisbeth (2008). Lidenskapens kapellmester... [Journal]. Dagens Medisin. Fulltekst i vitenarkiv
• Valeur, Jørgen & Gjelseth, May Reppen (2008). Hvem har mest makt - magen eller hjernen? [Radio]. Kveldsåpent, NRK P1. Fulltekst i vitenarkiv
• Valeur, Jørgen & Gjengedal, Kjerstin (2008). Forsker på magefølelse. [Internet]. Forskning.no. Fulltekst i vitenarkiv
• Valeur, Jørgen; Øines, Eliann; Morken, Mette Helvik; Lillestøl, Kristine; Lind, Ragna & Vaali, Kirsi Kaarina [Vis alle 10 forfattere av denne artikkelen] (2008). Neuroendocrine biomarkers of symptomatic carbohydrate malabsorption. Neurogastroenterology and Motility. ISSN 1350-1925. 20, s. 138–138. doi: 10.1111/j.1365-2982.2008.01190.x. Fulltekst i vitenarkiv
• Valeur, Jørgen; Lappalainen, Jani; Rita, Hannu; Lin, Aung Htun; Kovanen, Petri T. & Berstad, Arnold [Vis alle 8 forfattere av denne artikkelen] (2008). Jejunal dysmotility in a food allergy mouse model. Neurogastroenterology and Motility. ISSN 1350-1925. 20, s. 45–45. doi: 10.1111/j.1365-2982.2008.01190.x. Fulltekst i vitenarkiv
• Valeur, Jørgen & Gjengedal, Kjerstin (2008). Forsker på magefølelser. [Internet]. På høyden. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2008). Hvorfor har vi tykktarm? 128(11), s. 1298–1300. Fulltekst i vitenarkiv
• Valeur, Jørgen; Lappalainen, Jani; Lin, Aung Htun; Kovanen, Petri; Berstad, Arnold & Eklund, Kari [Vis alle 7 forfattere av denne artikkelen] (2008). Jejunal dysmotility in food allergy mouse model. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 43, s. 32–32. Fulltekst i vitenarkiv
• Valeur, Jørgen; Lappalainen, Jani; Rita, Hannu; Lin, Aung Htun; Kovanen, Petri T. & Berstad, Arnold [Vis alle 8 forfattere av denne artikkelen] (2008). Jejunal dysmotility in a food allergy mouse model. Fulltekst i vitenarkiv
• Valeur, Jørgen; Øines, Eliann; Morken, Mette Helvik; Lillestøl, Kristine; Lind, Ragna & Vaali, Kirsi Kaarina [Vis alle 10 forfattere av denne artikkelen] (2008). Neuroendocrine biomarkers of symptomatic carbohydrate malabsorption. Fulltekst i vitenarkiv
• Valeur, Jørgen; Milde, Anne Marita; Helle, Karen Blaauw & Berstad, Arnold (2008). Low serum chromogranin A in patients with self-reported food hypersensitivity. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 43(11), s. 1403–1404. doi: 10.1080/00365520802273074. Fulltekst i vitenarkiv
• Soares, Jelena Zugic; Bogdanovic, Nenad; Pettersen, Renate Regine; Selbæk, Geir & Valeur, Jørgen (2023). Vitamin D in cognitive impairment and Alzheimer´s disease. Universitetet i Oslo. Fulltekst i vitenarkiv Vis sammendrag

  Background Dementia, especially due to Alzheimer`s disease (AD), is a major and increasing health problem in the elderly population worldwide. To date there is no curative treatment. It is therefore crucial to examine all possibly modifiable factors for disease development; vitamin D deficiency is one of them. There are conflicting results regarding vitamin D and cognitive function in the literature, and little is known about the presence and impact of vitamin D in the human brain. Aim The aim of this study was to explore the possible significance of both serum and intrathecal Vitamin D for cognitive health in older persons. To achieve this, we investigated the following: 1. Vitamin D in serum in persons t 65 years and associations with cognitive performance (paper I). 2. The association between vitamin D levels in serum and volumetric MRI measurements of key brain regions in persons with cognitive impairment (paper II). 3. Serum/cerebrospinal fluid (CSF) ratios of vitamin D in people with good and poor cognitive health (paper III). 4. VDR gene polymorphisms in association with cognitive performance and vitamin D status (paper III). 5. The association between vitamin D levels in CSF and levels of biomarkers of Alzheimer's disease, β-amyloid, total tau protein and phosphorylated tau protein in CSF (paper IV). 6. The association between vitamin D levels in CSF and cytokine levels in CSF (paper IV). Methods Patient data were collected from the Norwegian register for persons assessed for cognitive symptoms. A control group was included in papers III and IV. Results In paper I, we found that lower levels of vitamin D in serum were associated with worse performance on cognitive tests of executive function. In paper II, the results showed an association between lower levels of vitamin D in serum and lower volumes of cortical grey matter. In paper III, we found that the relationship between vitamin D in serum and CSF was not linear. Further, we found that patients with a clinical diagnosis of AD had lower levels of vitamin D in CSF compared to the control group, despite normal serum vitamin D levels. In paper IV, the main finding was that lower levels of vitamin D in CSF were associated with pathological levels of tau protein and phosphorylated tau protein, but not with β-amyloid in CSF. We did not find a consistent association between polymorphisms of vitamin D receptor with vitamin D levels or cognition, nor an association between vitamin D levels in CSF and selected cytokines in CSF. Interpretation and conclusion The results of this study support the hypothesis that vitamin D can be an important part of brain health and raise the question of whether vitamin D in the brain can have a metabolism that is partly independent of its metabolism in blood.

• Bjørkhaug, Steinar Traae; Valeur, Jørgen; Bramness, Jørgen Gustav & Lien, Lars (2020). Alcohol-related alterations of the gut microbial flora. Universitetet i Oslo. Fulltekst i vitenarkiv
• Moore, Alison M.; Mathias, Manon & Valeur, Jørgen (2018). Special issue: Gut-brain Axis in History and Culture. Taylor & Francis. Fulltekst i vitenarkiv
• Undseth, Ragnhild Marie; Valeur, Jørgen; Berstad, Arnold & Kløw, Nils-Einar (2018). Irritable bowel syndrome. Clinical, pathophysiological and radiological aspects. Universitetet i Oslo. Fulltekst i vitenarkiv
• Valeur, Jørgen (2015). Special issue: Gut in Focus. Taylor & Francis. Fulltekst i vitenarkiv
• Malvik, Stine; Henriksen, Christine; Bjørkhaug, Steinar Traae & Valeur, Jørgen (2015). Ernæringsstatus hos personer med høyt alkoholinntak. Universitetet i Oslo. Fulltekst i vitenarkiv Vis sammendrag

  Bakgrunn: Det er gjort lite forskning på ernæringsstatus hos personer med høyt alkoholinntak i Norge. Denne gruppen antas å være spesielt utsatt for feilernæring da alkoholen inntas på bekostning av annen mat, samt påvirker næringsopptaket og omsetningen av næringsstoffer i kroppen. Det finnes mange ulike metoder for kartlegging av en persons ernæringsstatus, men hvilke som egner seg best til bruk på personer med alkoholavhengighet er usikkert. Mål: Det overordnede målet med masteroppgaven er å kartlegge ernæringsstatus hos en gruppe mennesker med høyt alkoholforbruk, sammenliknet med en referansegruppe, gjennom bruk av ulike metoder, samt undersøke samsvarheten til de ulike metodene. Deltakere og metode: I januar 2015 var 71 deltakere inkludert i denne studien, bestående av en forsøksgruppe (n=33) og en referansegruppe (n=23). Deltakerne er enten rekruttert fra prosjektet «Eldre og rusmisbruk» eller blant inneliggende pasienter ved Lovisenberg Diakonale Sykehus. KMI, vekttap, bioelektrisk impedansanalyse (BIA), gripestyrke, blodprøver og «Mini Nutritional Assessment» (MNA) ble brukt til å kartlegge studiepopulasjonens ernæringsstatus. Resultater: Overvekt eller fedme ble funnet hos 58 % av forsøkspersonene. MNA klassifiserte 36 % av forsøksgruppen som underernærte eller i risiko for underernæring, og det var høyere forekomst av redusert matlyst, depresjon, samt færre daglige måltider hos personer med høyt alkoholinntak sammenliknet med referansegruppen. Vitamin D mangel ble observert hos en stor andel av både forsøksgruppen og referansegruppen. Vitamin C mangel ble funnet hos 35 % av forsøkspersonene. Det var moderat samsvar mellom de ulike metodene MNA, KMI og estimering av vekttap. Kun én av 20 ble fanget opp med både MNA score tilsvarende underernæring, KMI tilsvarende undervekt og vekttap. Konklusjon: Denne studien viser at personer med høyt alkoholinntak har mange ernæringsutfordringer, og overvekt og fedme var vanligere i denne gruppen enn undervekt. Gruppen kjennetegnes ved redusert matlyst, depresjon, få måltider, og både vitamin C og D mangel var vanlig. Dårlig samsvar mellom de ulike kartleggingsmetodene viser nødvendigheten av å benytte seg av flere ulike metoder for å fange opp personer i ernæringsmessig risiko.

• Gregersen, Kine; Lied, Gülen Arslan; Valeur, Jørgen; Berstad, Arnold & Frøyland, Livar (2013). Subjective food hypersensitivity: Studies on enterochromaffin cell secretion products and effects of seal oil therapy. Universitetet i Bergen. ISSN 9788230822494. Fulltekst i vitenarkiv Vis sammendrag

  Background: Perceived food hypersensitivity is a prevalent condition which often remains medically unexplained. The etiology of this subjective condition is not fully understood, mainly because of a lack of specific diagnostic methods, together with limited knowledge about underlying pathogenetic mechanisms. Thus, the management of such patients is challenging. Aim: The objective of the present thesis was to assess the potential beneficial effects of seal oil on symptoms, and to develop a novel sample protocol to investigate the putative role of enteroendocrine secretorial compounds in patients with subjective food hypersensitivity. Results: In study I, a single dose of duodenal administered seal oil significantly influenced neither gastric accommodation, as examined by two dimensional (2D) ultrasonographic scanning, nor meal-induced gastrointestinal symptoms, as assessed by visual analogue scales (VAS). After 10 days’ treatment, duodenal administered seal oil, as compared to soy oil, significantly reduced meal-induced gastrointestinal symptoms. However, the symptomatic improvement was not associated with improvements in gastric accommodation. In study II, patients with subjective food hypersensitivity received a 10-day open treatment with duodenal administered seal oil. Before and after treatment, and 1 month post-treatment, the patients filled in the Subjective Health Complaints (SHC) Inventory for nongastrointestinal symptoms, the short form of the Nepean Dyspepsia Index (SF-NDI) for evaluation of quality of life (QoL), and the Ulcer Esophagitis Subjective Symptoms Scale (UESS) score and the Gastrointestinal Symptom Rating Scale (GSRS) for assessment of gastrointestinal symptoms. Both intestinal and extra-intestinal complaints were significantly improved from baseline, both at 10 and 30 days post-treatment. In study III, a novel method for direct determination of serotonin (5-HT) in gut lavage fluid using liquid chromatography mass spectrometry was achieved. This method was applied in study IV. In study IV, analyses of chromogranin A (CgA) in serum and 5-HT in gut lavage fluid were performed. Serum levels of CgA were significantly lower in patients with subjective food hypersensitivity as compared to healthy controls. No significant differences in gut lavage 5- HT levels were detected between patients with subjective food hypersensitivity, patients with inflammatory bowel disease (IBD) and healthy controls. Conclusion: The present thesis suggests a beneficial effect of duodenal administered seal oil on both intestinal and extra-intestinal complaints in patients with subjective food hypersensitivity. Impaired gastric accommodation seems to play a limited role in the pathophysiology, as the positive effect of seal oil was not associated with improvements in gastric accommodation. The mechanism of action may involve the anti-inflammatory and immune-modulating properties of the long-chain omega-3 polyunsaturated fatty acids (PUFAs), and further studies addressing this aspect are needed. Decreased systemic CgA levels suggest a role for enteroendocrine alterations in the pathophysiology of subjective food hypersensitivity, such as impaired enterochromaffin (EC) cell function, and the potential of using granins as biomarkers for functional gastrointestinal disorders should be explored in future studies. Taken together, the hypothesis-generating studies of the present thesis encourage further investigations to elucidate causal relationships between the patients’ unexplained symptoms and possible pathophysiological mechanisms.

• Hystad, Hilde Tang; Valeur, Jørgen & Berstad, Arnold (2012). Bør pasienter med irritabel tarm spise mindre tungt fordøyelige karbohydrater? Universitetet i Bergen. Fulltekst i vitenarkiv
• Valeur, Jørgen & Berstad, Arnold (2010). Unexplained, self-reported food hypersensitivity. Explorative studies on mechanisms of abdominal symptom generation. Universitetet i Bergen. ISSN 9788230815847. Fulltekst i vitenarkiv Vis sammendrag

  Background: Self-reported food hypersensitivity remains unexplained in most cases. Abdominal symptoms, typically consistent with the irritable bowel syndrome (IBS), are common in patients with such unexplained, self-reported food hypersensitivity. The etiology is obscure. Aim: The overall objective of the present study was to investigate possible mechanisms of postprandial abdominal symptom generation. A main purpose was to explore whether and how ingestion of low-digestible carbohydrates act as abdominal symptom triggers in patients with unexplained, self-reported food hypersensitivity. Main results: The findings can be summarized as follows: In study I, fructose-sorbitol malabsorption evoked more symptoms in patients with unexplained, self-reported food hypersensitivity than in healthy controls. Alterations in intestinal gas production and secretion of so-called ileal brake hormones (glucagon-like peptide 1 (GLP-1) and peptide YY (PYY)) could not be demonstrated. In study II, serum levels of chromogranin A (CgA) were found to be lower in patients with unexplained, self-reported food hypersensitivity than in healthy controls. In study III, lactulose malabsorption evoked more symptoms in patients with unexplained, self-reported food hypersensitivity than in healthy controls. The symptoms could not be fully explained by symptom anticipation, because lactulose induced more symptoms than placebo (glucose). Associated alterations in intestinal gas production and rectal levels of prostaglandin E2 (PGE2) and microbial fermentation products could not be demonstrated. In study IV, mechanisms of diarrhoea in a mouse model of food allergy were investigated. Changes within the jejunum were demonstrated in the food allergic mice, with development of muscular hypocontractility, increased levels of cytokines IL-4 and IL-6 and high numbers of mast cells. In study V, fecal levels of short-chain fatty acids (SCFA) were investigated, and the profile was different between patients with unexplained, self-reported food hypersensitivity and healthy controls. Increased proportions of butyric acid were demonstrated in the patient group, particularly in individuals with severe symptoms. Conclusion: Taken together, the results suggest that intolerance to low-digestible carbohydrates plays an important role in abdominal symptom generation in patients with unexplained, self-reported food hypersensitivity. Disturbances of intestinal motility may contribute to gastrointestinal symptom development by increasing the amount of malabsorbed carbohydrates. Altered intestinal fermentation is a potential cause of the patients’ unexplained symptoms.

• Vik, Natalia S.; Valeur, Jørgen & Morken, Mette Helvik (2009). Symptomer etter inntak av karbohydrater. En sammenligning av laktulose og glukose hos pasienter med selvrapportert matoverfølsomhet. Universitetet i Bergen. Fulltekst i vitenarkiv Vis sammendrag

  Bakgrunn: Unormale reaksjoner på inntak av mat rapporteres hos opptil 25 % av befolkningen, men kun et fåtall av disse har ekte matvareallergi. IBS (irritabel tarm) er en kronisk og plagsom, men i seg selv ufarlig lidelse, som karakteriseres ved magesmerter, gassproblematikk og avføringsforstyrrelser. De fleste pasienter med selvrapportert matoverfølsomhet har symptomer forenlig med IBS, og de fleste pasienter med IBS relaterer symptomene sine til matinntak. Om lag 20 % av karbohydratene i kosten passerer normalt ufordøyd gjennom tynntarmen, og karbohydratmalabsorpsjon fremkaller oftere mageplager hos IBS-pasienter enn hos friske. Forhold ved den metabolske aktiviteten til mikrobene i tykktarmen kan være en mulig årsak til slike plager. Hensikt: I denne studien ble laktulose, et kunstig disakkarid, brukt som modellsubstans for å fremkalle karbohydratmalabsorpsjon. Det er tidligere vist at 10 g laktulose gir mer mageplager hos pasienter med IBS enn hos friske. Hensikten med denne studien var å undersøke om inntak av 10 g laktulose også gir mer mageplager enn 10 g glukose (brukt som "placebo for karbohydratmalabsorpsjon") hos pasienter med selvrapportert matoverfølsomhet. Sammenhengen mellom gassproduksjon og symptomer ble også undersøkt. Materiale og metode: I studien inngikk 27 pasienter med selvrapportert matoverfølsomhet, hvorav 25 hadde IBS etter Roma II-kriteriene. Alle pasientene ble undersøkt med måling av gassutskillelse (H2 og CH4) og kartlegging av symptomer etter peroralt inntak av både laktulose og glukose, med en ukes mellomrom. Rekkefølgen var tilfeldig og undersøkelsen ble utført dobbelblindet. Resultater: Symptomer etter inntak av laktulose var signifikant verre enn symptomer etter inntak av glukose (P = 0.01). Tjue-en (78 %) pasienter angav reproduksjon av sine hverdagsplager etter inntak av laktulose, og 4 rapporterte sterkere plager enn normalt. Kvantitativt var symptomene etter inntak av laktulose signifikant korrelert til grad av hverdagsplager (r = 0.6, P = 0.001). Fjorten (52 %) pasienter fikk plager også ved inntak av glukose, men ingen av disse ble mer plaget enn normalt. Selv om de vanligste plagene etter inntak av laktulose var oppblåsthet og smerte, var ikke gassproduksjonen, målt som arealet under hydrogenekskresjonskurvene, korrelert til graden av symptomer. Konklusjon: Karbohydratmalabsorpsjon reproduserte grunnsymptomene til pasienter med selvrapportert matoverfølsomhet, og ubehaget etter inntak av laktulose var klart verre enn etter placebo. Dette kan tyde på at forhold ved bakteriefloraens fermentering av karbohydrater spiller en viktig rolle for symptomutviklingen hos pasienter med selvrapportert matoverfølsomhet.

• Puaschitz, Nathalie; Valeur, Jørgen & Morken, Mette Helvik (2009). Effekt av havregrynsgrøt på tykktarmens bakterieflora - en eksplorativ studie av fekal beta-galaktosidase- og ureaseaktivitet i tykktarmen hos friske forsøkspersoner. Universitetet i Bergen. Fulltekst i vitenarkiv

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