Juha Tapio Silvola

• Grønseth, Torstein; Vestby, Lene Karine; Nesse, Live Lingaas; Von Unge, Magnus & Silvola, Juha Tapio (2020). Bioactive glass S53P4 eradicates Staphylococcus aureus in biofilm/planktonic states in vitro. Uppsala Journal of Medical Sciences.  ISSN 0300-9734.  125(3), s 217- 225 . doi: 10.1080/03009734.2020.1765908 Fulltekst i vitenarkiv.
• Gladiné, Kilian; Wales, Jeremy; Silvola, Juha Tapio; Muyshondt, Pieter G.H.; Topsakal, V; Van de Heyning, Paul; Dirckx, Joris J.J. & Von Unge, Magnus (2019). Evaluation of Artificial Fixation of the Incus and Malleus With Minimally Invasive Intraoperative Laser Vibrometry (MIVIB) in a Temporal Bone Model. Otology & Neurotology.  ISSN 1531-7129. . doi: 10.1097/MAO.0000000000002444
• Moene, Lise Carine Johansen; Hauge, Mats; Silvola, Juha Tapio & Bachmann-Harildstad, Gregor (2019). In vitro surface temperature of nasal balloons during hot water inflation. Rhinology Online.  ISSN 2589-5613. . doi: 10.4193/Rhinol/19.012 Fulltekst i vitenarkiv.
• Rødvik, Arne Kirkhorn; Tvete, Ole; Torkildsen, Janne von Koss; Wie, Ona Bø; Skaug, Ingebjørg & Silvola, Juha Tapio (2019). Consonant and Vowel Confusions in Well-Performing Children and Adolescents With Cochlear Implants, Measured by a Nonsense Syllable Repetition Test. Frontiers in Psychology.  ISSN 1664-1078.  10, s 1- 17 . doi: 10.3389/fpsyg.2019.01813 Vis sammendrag

  Although the majority of early implanted, profoundly deaf children with cochlear implants (CIs), will develop correct pronunciation if they receive adequate oral language stimulation, many of them have difficulties with perceiving minute details of speech. The main aim of this study is to measure the confusion of consonants and vowels in well-performing children and adolescents with CIs. The study also aims to investigate how age at onset of severe to profound deafness influences perception. The participants are 36 children and adolescents with CIs (18 girls), with a mean (SD) age of 11.6 (3.0) years (range: 5.9–16.0 years). Twenty-nine of them are prelingually deaf and seven are postlingually deaf. Two reference groups of normal-hearing (NH) 6- and 13-year-olds are included. Consonant and vowel perception is measured by repetition of 16 bisyllabic vowel-consonant-vowel nonsense words and nine monosyllabic consonant-vowel-consonant nonsense words in an open-set design. For the participants with CIs, consonants were mostly confused with consonants with the same voicing and manner, and the mean (SD) voiced consonant repetition score, 63.9 (10.6)%, was considerably lower than the mean (SD) unvoiced consonant score, 76.9 (9.3)%. There was a devoicing bias for the stops; unvoiced stops were confused with other unvoiced stops and not with voiced stops, and voiced stops were confused with both unvoiced stops and other voiced stops. The mean (SD) vowel repetition score was 85.2 (10.6)% and there was a bias in the confusions of [i:] and [y:]; [y:] was perceived as [i:] twice as often as [y:] was repeated correctly. Subgroup analyses showed no statistically significant differences between the consonant scores for pre- and postlingually deaf participants. For the NH participants, the consonant repetition scores were substantially higher and the difference between voiced and unvoiced consonant repetition scores considerably lower than for the participants with CIs. The participants with CIs obtained scores close to ceiling on vowels and real-word monosyllables, but their perception was substantially lower for voiced consonants. This may partly be related to limitations in the CI technology for the transmission of low-frequency sounds, such as insertion depth of the electrode and ability to convey temporal information.

• Silvola, Juha Tapio; Sinkkonen, Saku T; Wanscher, Jens; Westman, Eva; Holm, Niels H. & Ovesen, Therese (2019). The status of Eustachian tube balloon dilations in Nordic countries. World Journal of Otorhinolaryngology - Head and Neck Surgery.  ISSN 2095-8811. . doi: 10.1016/j.wjorl.2019.09.002 Fulltekst i vitenarkiv.
• Falkenberg-Jensen, Benedicte; Hopp, Einar; Jablonski, Greg Eigner; Pripp, Are Hugo & Silvola, Juha Tapio (2018). The cartilaginous Eustachian tube: Reliable CT measurement and impact of the length. American Journal of Otolaryngology.  ISSN 0196-0709.  39(4), s 436- 440 . doi: 10.1016/j.amjoto.2018.04.010 Fulltekst i vitenarkiv.
• Luukkainen, Veera; Kivekäs, Ilkka; Silvola, Juha Tapio; Jero, Jussi & Sinkkonen, Saku T (2018). Balloon eustachian tuboplasty: Systematic review of long-term outcomes and proposed indications. The Journal of International Advanced Otology.  ISSN 1308-7649.  14(1), s 112- 126 . doi: 10.5152/iao.2018.4769 Fulltekst i vitenarkiv.
• Pöyhönen, Leena; Kivekäs, Ilkka; Silvola, Juha Tapio; Poe, Dennis & Rautiainen, Markus (2018). Mucociliary function of the eustachian tube in the eustachian tube dysfunction. Acta Oto-Laryngologica.  ISSN 0001-6489. . doi: 10.1080/00016489.2018.1562218
• Rødvik, Arne Kirkhorn; Torkildsen, Janne von Koss; Wie, Ona Bø; Storaker, Marit Aarvaag & Silvola, Juha Tapio (2018). Consonant and vowel identification in cochlear implant users measured by nonsense words: A systematic review and meta-analysis. Journal of Speech, Language and Hearing Research.  ISSN 1092-4388.  61(4), s 1023- 1050 . doi: 10.1044/2018_JSLHR-H-16-0463 Fulltekst i vitenarkiv.
• Grønseth, Torstein; Vestby, Lene Karine; Nesse, Live Lingaas; Thoen, Even; Habimana, Olivier; Von Unge, Magnus & Silvola, Juha Tapio (2017). Lugol's solution eradicates Staphylococcus aureus biofilm in vitro. International Journal of Pediatric Otorhinolaryngology.  ISSN 0165-5876.  103, s 58- 64 . doi: 10.1016/j.ijporl.2017.09.025 Fulltekst i vitenarkiv. Vis sammendrag

  Objectives The aim of the study was to evaluate the antibacterial efficacy of Lugol's solution, acetic acid, and boric acid against Staphylococcus aureus biofilm. Methods The efficacy of Lugol's solution 1%, 0.1%, and 0.05%, acetic acid 5% or boric acid 4.7% for treatment of Staphylococcus aureus biofilm in vitro was tested using 30 clinical strains. Susceptibility in the planktonic state was assessed by disk diffusion test. Antiseptic effect on bacteria in biofilm was evaluated by using a Biofilm-oriented antiseptic test (BOAT) based on metabolic activity, a biofilm bactericidal test based on culturing of surviving bacteria and confocal laser scanning microscopy combined with LIVE/DEAD staining. Results In the planktonic state, all tested S. aureus strains were susceptible to Lugol's solution and acetic acid, while 27 out of 30 tested strains were susceptible to boric acid. In biofilm the metabolic activity was significantly reduced following exposure to Lugol's solution and 5% acetic acid, while boric acid exposure led to no significant changes in metabolic activities. In biofilm, biocidal activity was observed for Lugol's solution 1% (30/30), 0.1% (30/30), and 0.05% (26/30). Acetic acid and boric acid showed no bactericidal activity in this test. Confocal laser scanning microscopy, assessed in 4/30 strains, revealed significantly fewer viable biofilm bacteria with Lugol's solution (1% p < 0.001, 0.1% p = 0.001 or 0.05% p = 0.001), acetic acid 5% for 10 min (p = 0.001) or 30 min (p = 0.015), but not for acetic acid for 1 min or boric acid. Conclusion Lugol's solution 1.0% and 0.1% effectively eradicated S. aureus in biofilm and could be an alternative to conventional topical antibiotics where S. aureus biofilm is suspected such as external otitis, pharyngitis and wounds.

• Koskinen, Anni; Mattila, Petri; Myller, Jyri; Penttilä, Matti; Silvola, Juha Tapio; Alastalo, Ismo; Huhtala, Heini; Hytönen, Maija & Toppila-Salmi, Sanna (2017). Comparison of intra-operative characteristics and early post-operative outcomes between endoscopic sinus surgery and balloon sinuplasty. Acta Oto-Laryngologica.  ISSN 0001-6489.  137(2), s 202- 206 . doi: 10.1080/00016489.2016.1227476
• Falkenberg-Jensen, Benedicte; Silvola, Juha Tapio; Laurvik, Helene; Lervik, Andreas; Kristiansen, Joanna; Jablonski, Greg & Hopp, Einar (2016). CT imaging of the eustachian tube using focal contrast medium administration: a feasibility study. Laryngoscope Investigative Otolaryngology.  ISSN 2378-8038.  1(4), s 83- 87 . doi: 10.1002/lio2.24 Fulltekst i vitenarkiv.
• Koskinen, Anni; Myller, Jyri; Mattila, Petri; Penttilä, Matti; Silvola, Juha Tapio; Alastalo, Ismo; Huhtala, Heini; Hytönen, Maija & Toppila-Salmi, Sanna (2016). Long-term follow-up after ESS and balloon sinuplasty: Comparison of symptom reduction and patient satisfaction. Acta Oto-Laryngologica.  ISSN 0001-6489.  136(5), s 532- 536 . doi: 10.3109/00016489.2015.1129553
• Nordfalk, Karl Fredrik; Rasmussen, Kjell; Hopp, Einar; Bunne, Marie; Silvola, Juha Tapio & Jablonski, Greg (2016). Insertion Depth in Cochlear Implantation and Outcome in Residual Hearing and Vestibular Function. Ear and Hearing.  ISSN 0196-0202.  37(2), s e129- e137 . doi: 10.1097/AUD.0000000000000241
• Kivekäs, Ilkka; Chao, Wei-Chieh; Faquin, William; Hollowell, Monica; Silvola, Juha Tapio; Rasooly, Tali & Poe, Dennis (2015). Histopathology of balloon-dilation eustachian tuboplasty. The Laryngoscope.  ISSN 0023-852X.  125(2), s 436- 441 . doi: 10.1002/lary.24894
• Silvola, Juha Tapio; Kivekäs, Ilkka & Poe, Dennis S. (2014). Balloon dilation of the cartilaginous portion of the Eustachian tube. Otolaryngology - Head and Neck Surgery (OTO).  ISSN 0194-5998.  151(1), s 125- 130 . doi: 10.1177/0194599814529538

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• Rødvik, Arne Kirkhorn; Tvete, Ole; Torkildsen, Janne von Koss; Wie, Ona Bø; Skaug, Ingebjørg & Silvola, Juha Tapio (2019). Perception of speech features compared for two groups of cochlear implant stimulation strategies.
• Rødvik, Arne Kirkhorn; Skaug, Ingebjørg; Torkildsen, Janne von Koss; Tvete, Ole; Perold, Jennifer; Wie, Ona Bø & Silvola, Juha Tapio (2018). Can consonant and vowel perception in well-performing Afrikaans- and Norwegian-speaking cochlear implant users be assessed by a cross-linguistic nonsense syllable repetition test?.
• Rødvik, Arne Kirkhorn; Tvete, Ole; Wie, Ona Bø; Torkildsen, Janne von Koss; Skaug, Ingebjørg & Silvola, Juha Tapio (2017). Consonant and vowel repetition in children with cochlear implants measured by a nonsense syllable hearing test.
• Grønseth, Torstein; Vestby, Lene Karine; Nesse, Live Lingaas; Von Unge, Magnus; Thoen, Even & Silvola, Juha Tapio (2016). The effect of Lugol’s solution and boric acid on Staphylococcus aureus biofilm.
• Falkenberg-Jensen, Benedicte; Silvola, Juha Tapio; Laurvik, Helene; Kristiansen, Joanna; Lervik, Andreas; Jablonski, Greg & Hopp, Einar (2014). Contrast enhanced visualisation of the Eustachian tube..
• Rødvik, Arne K; Silvola, Juha Tapio; Torkildsen, Janne von Koss & Wie, Ona Bø (2014). Speech sound identification by adults and children with a cochlear implant.
• Rødvik, Arne K; Silvola, Juha Tapio; Torkildsen, Janne von Koss & Wie, Ona Bø (2014). Speech sound identification by children and adults with cochlear implants.

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