Lars Nilsson

English version of this page
Telefon +47-22840221
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postadresse Postboks 1057 Blindern 0316 OSLO

Faglige interesser

  • Alzheimers sykdom
  • Amyloidose
  • CNS-farmakologi
  • Neurodegeneration


  • Farmakologi-undervisning for medisinstudenter


  • Apotekarexamen, Uppsala Universitet, 1988
  • PhD Neurobiologi, Karolinska Institutet, 1996
  • Postdoctoral fellow, Hardvard Medical School og University South Florida, USA, 1998-2002
  • Senior Forskare, Uppsala Universitet, Sverige, 2003-2011
  • Professor I Farmakologi, Universitetet i Oslo, 2012-
Emneord: Nevrodegenerative sykdommer, Hjerne og nervesystem


Utvalgte publikasjoner

  • Jendresen C, Årskog V, Daws MR, Nilsson LNG  (2017) The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. J Neuroinflammation 14(1):59.
  • Henjum K, Almdahl IS, Årskog V, Minthon L, Hansson O, Fladby T, Nilsson LNG (2016) Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease. Alzheimers Res Ther. 27;8(1):17.
  • Rogeberg M., Almdahl IS., Wettergren M., Nilsson LNG., Fladby T (2015) Isobaric Quantification of Cerebrospinal Fluid Amyloid-β Peptides in Alzheimer's Disease: C-Terminal Truncation Relates to Early Measures of Neurodegeneration. J Proteome Res 14, 4834-43.
  • Rogeberg M, Wettergreen M, Nilsson LNG, Fladby T (2015) Identification of amyloid-β mid-domain fragments in human cerebrospinal fluid. Biochimie, 113:86-92.
  • Jendresen CB, Cui H, Zhang X, Vlodavsky I, Nilsson LNG, Li JP, (2015) Overexpression of heparanase lowers amyloid burden in AβPP transgenic mice. J Biol. Chem. 290:5053-64.
  • Nuruddin S., Syverstad GH., Lillehaug S., Leergaard TB., Nilsson LNG., Ropstad E.,  Krogenæsa A., Haraldsen I., Torp R. (2014) Elevated mRNA-levels of gonadotropin-releasing hormone and its receptor in plaque-bearing Alzheimer´s disease transgenic mice. Plos One 9(8):e103607.
  • Lillehaug SD., Syverstad GH., Nilsson LNG., Bjaalie JG., Leergaard TB., Torp R. (2014) Brain-wide distribution and variance of amyloid-beta load in middle aged -transgenic Alzheimer’s disease mice with both the Artic and Swedish AβPP mutations. Neurobiol Aging 35(3):556-64.
  • Gumucio A., Lannfelt L., Nilsson LNG (2013) Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging. BMC Neurosci. 14:148.
  • Lillenes MS., Støen M., Torp R., Nilsson LNG., Günter C-C., Tonjum T. (2013) Transient changes in expression of OGG1, APE1 and PolB in the brains of mice expressing mutant amyloid-β precursor protein (AβPP). Mech. Ageing Dev 134(10):467-77.  
  • Philipson O, Lord A, Lalowski M, Soliyman R, Thyberg R, Baumann M, Thyberg J, Bogdanovic N, Olofsson T, Tjernberg L, Ingelsson I, Lannfelt L, Kalimo H and Nilsson LNG (2011) The Arctic mutation results in distinct plaques and accumulation of N- and C-truncated Aβ. Neurobiology of Aging, PMID: 22118948.
  • Yang J., Olson L., Nuntagij P., Oguchi T., Camassa LMA, Nilsson LNG, Lannfelt L., Xu Y., Amiry-Moghaddam M., Ottersen OP., Torp R. (2011) Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer’s disease. Journal Alzheimer’s disease 27(4):711-22.
  • Lord A, Philipson P, Klingstedt T, Westermark G, Hammarström P, Nilsson KP and Nilsson LNG (2011) Observations in APP bitransgenic mice suggest that diffuse and compact plaques form by independent processes in Alzheimer’s disease. American Journal of Pathology, 178(5): 2286-2298.
  • Codita, A, Gumucio A, Lannfelt L, Gellerfors P, Winblad B, Mohammed A.K, Nilsson LNG (2010) Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: a longitudinal study. Behav. Brain Research, 215:83-94.
  • Philipson O., Lannfelt L. and Nilsson LNG (2009) Genetic and pharmacological evidence of intraneuronal Aβ accumulation in APP transgenic mice. FEBS Lett., 583: 3021-6.
  • Lord A., Gumucio-Gatica A., Englund H., Sehlin D., Sundquist V., Söderberg L., Möller C., Gellerfors P., Lannfelt L., Ekholm Pettersson F. and Nilsson LNG (2009) An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer’s disease. Neurobiol. Dis., 36: 425-34.
  • Lord A., Englund H., Söderberg L., Tucker S., Clausen F., Hillered L., Gordon MN., Morgan D., Lannfelt L., Ekholm-Pettersson F., Nilsson LNG (2009) Amyloid-β protofibrils correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice. FEBS.J., 276, 995-1006.
  • Philipsson O., Hammarström P., Nilsson PKR., Portelius E., Blennow K., Olofsson T., Ingelson M., Hyman BT., Blennow K., Lannfelt L., Kalimo H., Nilsson LNG  (2009) A highly insoluble state of Aβ is found in both Alzheimer´s disease brain and in transgenic mice with the Arctic mutation. Neurobiol. Aging 30:1393-1405.
  • Lord A., Kalimo H., Eckman C., Zhang X-Q., Lannfelt L. and Nilsson LNG (2006) The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic mice. Neurobiol. Aging, 27: 67-77.
  • Stenh C., Englund H., Lord A., Johansson A-S., Almeida CG, Gellerfors P., Greengard P., Gouras GK., Lannfelt L., Nilsson LNG (2005) Oligomers of amyloid- are inefficiently measured by ELISA. Ann Neurol., 58: 147-150.
  • Nilsson LNG, Arendash GW., Low MA., Leighty RE., Costa DA., Rojiani A., Wu X., Bales KR., Paul SM. and Potter H. (2004) Cognitive impairment in PDAPP mice depends on Apolipoprotein E and ACT-catalyzed amyloid formation. Neurobiol. Aging, 25(9): 1153-67.
  • Nilsson LNG, Bales KR., DiCarlo G., Gordon MN., Morgan D., Paul SM. and Potter H. (2001) Alpha-1-antichymotrypsin promotes -sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer’s disease. J. Neurosci., 21(5): 1444-1451.
  • Rogers J., Leiter L., McPhee J., Zhan SS., Potter H. and Nilsson LNG (1999) Translation of the Alzheimer’s amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5’ untranslated region sequences. J. Biol. Chem., 274(10): 6421-6431.
  • Jendresen, Charlotte Bille; Digre, Andreas; Cui, Hao; Zhang, Xiao; Vlodavsky, Israel; Li, Jin-Ping & Nilsson, Lars (2019). Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression. Scientific Reports.  ISSN 2045-2322.  9:4600(1), s 1- 12 . doi: 10.1038/s41598-019-40999-4 Fulltekst i vitenarkiv.
  • Nordengen, Kaja; Kirsebom, Bjørn-Eivind; Henjum, Kristi; Selnes, Per; Gisladottir, Berglind; Wettergreen, Marianne; Torsetnes, Silje Bøen; Grøntvedt, Gøril Rolfseng; Waterloo, Knut; Aarsland, Dag; Nilsson, Lars & Fladby, Tormod (2019). Glial activation and inflammation along the Alzheimer's disease continuum. Journal of Neuroinflammation.  ISSN 1742-2094.  16(46) . doi: 10.1186/s12974-019-1399-2 Fulltekst i vitenarkiv.
  • Henjum, Kristi; Paulsen, Else Quist; Zetterberg, Henrik; Blennow, Kaj; Nilsson, Lars & Watne, Leiv (2018). CSF sTREM2 in delirium - Relation to Alzheimer's disease CSF biomarkers A?42, t-tau and p-tau 11 Medical and Health Sciences 1109 Neurosciences 11 Medical and Health Sciences 1103 Clinical Sciences. Journal of Neuroinflammation.  ISSN 1742-2094.  15(1), s 1- 15 . doi: 10.1186/s12974-018-1331-1 Fulltekst i vitenarkiv.
  • Jendresen, Charlotte Bille; Daws, Michael Rory & Nilsson, Lars (2018). An improved CPRG colorimetric ligand-receptor signal transduction assay based on beta-galactosidase activity in mammalian BWZ-reporter cells. Journal of pharmacological and toxicological methods.  ISSN 1056-8719.  90, s 67- 75 . doi: 10.1016/j.vascn.2017.11.004 Fulltekst i vitenarkiv.
  • Jendresen, Charlotte Bille; Årskog, Vibeke Helen; Daws, Michael Rory & Nilsson, Lars (2017). The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. Journal of Neuroinflammation.  ISSN 1742-2094.  14:59, s 1- 13 . doi: 10.1186/s12974-017-0835-4
  • Henjum, Kristi; Almdahl, Ina; Årskog, Vibeke Helen; Minthon, Lennart; Hansson, Oskar; Fladby, Tormod & Nilsson, Lars (2016). Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease. Alzheimer's Research & Therapy.  ISSN 1758-9193.  8(1) . doi: 10.1186/s13195-016-0182-1
  • Nordeman, Patrik; Johansson, Leif B.G.; Bäck, Marcus; Estrada, Sergio; Hall, Håkan; Sjölander, Daniel; Westermark, Gunilla T.; Westermark, Per; Nilsson, Lars; Hammarström, Per; Nilsson, K. Peter R. & Antoni, Gunnar (2016). <sup>11</sup>C and <sup>18</sup>F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates. ACS Medicinal Chemistry Letters.  ISSN 1948-5875.  7(4), s 368- 373 . doi: 10.1021/acsmedchemlett.5b00309
  • Jendresen, Charlotte Bille; Cui, Hao; Zhang, Xiao; Vlodavsky, Israel; Nilsson, Lars & Li, Jin-Ping (2015). Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor Protein Transgenic mice. Journal of Biological Chemistry.  ISSN 0021-9258.  290(8), s 5053- 5064 . doi: 10.1074/jbc.M114.600569
  • Røgeberg, Magnus; Almdahl, Ina; Wettergreen, Marianne; Nilsson, Lars & Fladby, Tormod (2015). Isobaric Quantification of Cerebrospinal Fluid Amyloid-β Peptides in Alzheimer's Disease: C-Terminal Truncation Relates to Early Measures of Neurodegeneration. Journal of Proteome Research.  ISSN 1535-3893.  14(11), s 4834- 4843 . doi: 10.1021/acs.jproteome.5b00668
  • Røgeberg, Magnus; Wettergreen, Marianne; Nilsson, Lars & Fladby, Tormod (2015). Identification of amyloid beta mid-domain fragments in human cerebrospinal fluid. Biochimie.  ISSN 0300-9084.  113, s 86- 92 . doi: 10.1016/j.biochi.2015.03.022
  • Lillehaug, Sveinung; Syverstad, Gry-Helen Enger; Nilsson, Lars; Bjaalie, Jan G.; Leergaard, Trygve Brauns & Torp, Reidun (2014). Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice. Neurobiology of Aging.  ISSN 0197-4580.  35(3), s 556- 564 . doi: 10.1016/j.neurobiolaging.2013.09.013
  • Nuruddin, Syed; Syverstad, Gry-Helen Enger; Lillehaug, Sveinung; Leergaard, Trygve Brauns; Nilsson, Lars; Ropstad, Erik; Krogenæs, Anette; Haraldsen, Ira Hebold & Torp, Reidun (2014). Elevated mRNA-Levels of Gonadotropin-Releasing Hormone and Its Receptor in Plaque-Bearing Alzheimer's Disease Transgenic Mice. PLOS ONE.  ISSN 1932-6203.  9(8) . doi: 10.1371/journal.pone.0103607
  • Gumucio, Astrid; Lannfelt, Lars & Nilsson, Lars (2013). Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging. BMC Neuroscience.  ISSN 1471-2202.  14:148 . doi: 10.1186/1471-2202-14-148
  • Lillenes, Meryl Sønderby; Støen, Mari; Gómez-Muñoz, Marta; Torp, Reidun; Günther, Clara-Cecilie; Nilsson, Lars & Tønjum, Tone (2013). Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model. Mechanisms of Ageing and Development.  ISSN 0047-6374.  134(10), s 467- 477 . doi: 10.1016/j.mad.2013.09.002 Vis sammendrag
  • Magnusson, Kristina; Sehlin, Dag; Syvänen, Stina; Svedberg, Marie M.; Philipson, Ola; Söderberg, Linda; Tegerstedt, Karin; Holmquist, Mats; Gellerfors, Pär; Tolmachev, Vladimir; Antoni, Gunnar; Lannfelt, Lars; Hall, Håkan & Nilsson, Lars (2013). Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain. Journal of Alzheimer's Disease.  ISSN 1387-2877.  37(1), s 29- 40 . doi: 10.3233/JAD-130029
  • Philipson, O; Lord, A; Lalowski, M; Soliymani, R; Baumann, M; Thyberg, J; Bogdanovic, N; Olofsson, T; Tjernberg, LO; Ingelsson, M; Lannfelt, L; Kalimo, H & Nilsson, Lars (2012). The Arctic amyloid-beta precursor protein (A beta PP) mutation results in distinct plaques and accumulation of N- and C-truncated A beta. Neurobiology of Aging.  ISSN 0197-4580.  33(5) . doi: 10.1016/j.neurobiolaging.2011.10.022

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Publisert 26. jan. 2012 10:00 - Sist endret 2. mai 2017 14:14