Linn Nilsen Rødevand

• Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; O'Connell, Kevin; Elvsåshagen, Torbjørn; Winterton, Adriano; Quintana, Daniel; Hindley, Guy Frederick Lanyon; Werner, Maren Caroline Frogner; Djurovic, Srdjan; Dale, Anders Martin; Lagerberg, Trine Vik; Steen, Nils Eiel & Andreassen, Ole Andreas (2021). Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Translational Psychiatry.  ISSN 2158-3188.  11(1) . doi: 10.1038/s41398-020-01142-4 Fulltekst i vitenarkiv. Vis sammendrag

  Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, SMDs, and CVD risk factors remain unknown. Here we explored overlapping genetic architecture and genetic loci shared between SMDs, loneliness, and CVD risk factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), loneliness and CVD risk factors using bivariate causal mixture mode (MiXeR), which estimates the total amount of shared variants, and conditional false discovery rate to evaluate overlap in specific loci. We observed substantial genetic overlap between SMDs, loneliness and CVD risk factors, beyond genetic correlation. We identified 149 loci jointly associated with loneliness and SMDs (MD n = 67, SCZ n = 54, and BD n = 28), and 55 distinct loci jointly associated with loneliness and CVD risk factors. A total of 153 novel loneliness loci were found. Most of the shared loci possessed concordant effect directions, suggesting that genetic risk for loneliness may increase the risk of both SMDs and CVD. Functional analyses of the shared loci implicated biological processes related to the brain, metabolic processes, chromatin and immune system. Altogether, the study revealed polygenic overlap between loneliness, SMDs and CVD risk factors, providing new insights into their shared genetic architecture and common genetic mechanisms.

• Hjell, Gabriela; Mørch-Johnsen, Lynn; Holst, René; Tesli, Natalia; Bell, Christina; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Werner, Maren Caroline Frogner; Melle, Ingrid; Andreassen, Ole Andreas; Lagerberg, Trine Vik; Steen, Nils Eiel & Haukvik, Unn Kristin H. (2020). Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior.  ISSN 2162-3279.  10(9) . doi: 10.1002/brb3.1751 Fulltekst i vitenarkiv.
• Trondalen, Gro; Mangersnes, Julie; Bonde, Lars Ole; Malik, Sadaf; Asprusten, Tarjei Tørre; Rødevand, Linn Nilsen; Pedersen, Maria & Wyller, Vegard Bruun Bratholm (2020). Music Therapy for Chronic Fatigue Following Epstein-Barr Virus Infection in Adolescents. Music and Medicine.  ISSN 1943-863X.  12(2) . doi: 10.47513/mmd.v12i2.679
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders. Schizophrenia Research.  ISSN 0920-9964.  218, s 55- 62 . doi: 10.1016/j.schres.2020.03.006 Fulltekst i vitenarkiv.
• Winterton, Adriano; Rødevand, Linn; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Associations of loneliness and social isolation with cardiovascular and metabolic health: A systematic review and meta-analysis protocol. Systematic Reviews.  ISSN 2046-4053.  9(1) . doi: 10.1186/s13643-020-01369-8 Fulltekst i vitenarkiv.
• Rødevand, Linn; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna; Mørch, Ragni Helene; Lunding, Synve Hoffart; Vedal, Trude Seselie Jahr; Dieset, Ingrid; Melle, Ingrid; Lagerberg, Trine Vik & Andreassen, Ole Andreas (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139(4), s 348- 360 . doi: 10.1111/acps.13008 Vis sammendrag

  Objective: While CVD risk has decreased in the general population during the last decade, the situation in patients with schizophrenia (SCZ) and bipolar disorder (BD) is unknown. Methods: We compared CVD risk factors in patients with SCZ and BD recruited from 2002‐2005 (2005 sample, N = 270) with patients recruited from 2006‐2017 (2017 sample, N = 1011) from the same catchment area in Norway. The 2017 sample was also compared with healthy controls (N = 922) and the general population (N range = 1285‐4587, Statistics Norway) from the same area and period. Results: Patients with SCZ and BD in the 2017 sample had significantly higher level of most CVD risk factors compared to healthy controls and the general population. There was no significant difference in the prevalence of CVD risk factors in SCZ between the 2005 and 2017 samples except a small increase in glucose in the 2017 sample. There were small‐to‐moderate reductions in hypertension, obesity, total cholesterol, low‐density lipoprotein, systolic and diastolic blood pressure in the BD 2017 sample compared to the 2005 sample. Conclusion: Despite major advances in health promotion during the past decade, there has been no reduction in the level of CVD risk factors in patients with SCZ and modest improvement in BD.

• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology.  ISSN 0306-4530.  103, s 87- 95 . doi: 10.1016/j.psyneuen.2019.01.001 Fulltekst i vitenarkiv.
• Linnemørken, Lene Therese Bergerud; Sveinsdottir, Vigdis; Knutzen, Thomas; Rødevand, Linn Nilsen; Hernæs, Kjersti Helene & Reme, Silje Endresen (2018). Protocol for the Individual Placement and Support (IPS) in Pain Trial: A randomized controlled trial investigating the effectiveness of IPS for patients with chronic pain. BMC Musculoskeletal Disorders.  ISSN 1471-2474.  19(47) . doi: 10.1186/s12891-018-1962-5 Fulltekst i vitenarkiv.
• Tschudi-Madsen, Hedda; Rødevand, Linn; Kaarbø, Mette Bøymo & Granan, Lars-Petter (2018). Chronic Widespread Pain in a tertiary pain clinic: Classification overlap and use of a patient generated quality of life instrument. Scandinavian Journal of Pain.  ISSN 1877-8860.  s 1- 11 . doi: 10.1515/sjpain-2018-0097
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research.  ISSN 0022-3956.  106, s 74- 81 . doi: 10.1016/j.jpsychires.2018.09.014
• Mikkelsen, Rebecka; Rødevand, Linn Nilsen; Wiik, Ulrikke Straume; Zahl, Sverre Morten; Berntsen, Torhild; Skarbø, Anne-Britt; Egge, Arild; Helseth, Eirik; Andersson, Stein & Wester, Knut (2017). Neurocognitive and psychosocial function in children with benign external hydrocephalus (BEH)-a long-term follow-up study.. Child's Nervous System.  ISSN 0256-7040.  33(1), s 91- 99 . doi: 10.1007/s00381-016-3267-z
• Rødevand, Linn Nilsen (2017). Hvordan er det å være ungdom og leve med kronisk utmattelsessyndrom/myalgisk encefalopati? En narrativ oversikt. Scandinavian Psychologist.  ISSN 1894-5570.  2017(4), s 1- 27 . doi: 10.15714/scandpsychol.4.e1
• Rødevand, Linn Nilsen; Ljoså, Tone Marte; Granan, Lars-Petter; Knutzen, Thomas; Jacobsen, Henrik Børsting & Reme, Silje Endresen (2017). A pilot study of the individual placement and support model for patients with chronic pain. BMC Musculoskeletal Disorders.  ISSN 1471-2474.  18(1) . doi: 10.1186/s12891-017-1908-3 Fulltekst i vitenarkiv.

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• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?. Journal of Psychiatric Research.  ISSN 0022-3956. . doi: 10.1016/j.jpsychires.2018.11.012
• Rødevand, Linn Nilsen (2017). Gi kroppen mer plass.. Tidsskrift for Norsk Psykologforening.  ISSN 0332-6470.  54(6), s 578- 583

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