Ludvig Magne Sollid

• Høydahl, Lene Støkken; Richter, Lisa Maria; Frick, Rahel; Snir, Omri; Gunnarsen, Kristin Støen; Landsverk, Ole J. B.; Iversen, Rasmus; Jeliazkov, Jeliazko R.; Gray, Jeffrey J.; Bergseng, Elin; Foss, Stian; Qiao, Shuo Wang; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Jahnsen, Frode Lars; Sandlie, Inger; Sollid, Ludvig Magne & Løset, Geir Åge (2019). Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease. Gastroenterology.  ISSN 0016-5085.  156(5), s 1428- 1439.e10 . doi: 10.1053/j.gastro.2018.12.013
• Dahal-Koirala, Shiva; Ciacchi, Laura; Petersen, Jan; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Christophersen, Asbjørn; Lundin, Knut Erik Aslaksen; Reid, Hugh H.; Qiao, Shuo Wang; Rossjohn, Jamie & Sollid, Ludvig Magne (2018). Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes. Journal of Biological Chemistry.  ISSN 0021-9258.  294(3), s 941- 952 . doi: 10.1074/jbc.RA118.005736
• Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Neumann, Ralf Stefan; Bjerregaard-Andersen, Kaare; Nilssen, Nicolay Rustad; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2018). Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system. PLoS ONE.  ISSN 1932-6203.  13:e0195868(4), s 1- 15 . doi: 10.1371/journal.pone.0195868 Fulltekst i vitenarkiv. Vis sammendrag

  There is a quest for production of soluble protein of high quality for the study of T-cell receptors (TCRs), but expression often results in low yields of functional molecules. In this study, we used an E. coli chaperone-assisted periplasmic production system and compared expression of 4 different soluble TCR formats: single-chain TCR (scTCR), two different disulfide-linked TCR (dsTCR) formats, and chimeric Fab (cFab). A stabilized version of scTCR was also included. Additionally, we evaluated the influence of host (XL1-Blue or RosettaBlueTM) and the effect of IPTG induction on expression profiles. A celiac disease patient-derived TCR with specificity for gluten was used, and we achieved detectable expression for all formats and variants. We found that expression in RosettaBlueTM without IPTG induction resulted in the highest periplasmic yields. Moreover, after large-scale expression and protein purification, only the scTCR format was obtained in high yields. Importantly, stability engineering of the scTCR was a prerequisite for obtaining reliable biophysical characterization of the TCR-pMHC interaction. The scTCR format is readily compatible with high-throughput screening approaches that may enable both development of reagents allowing for defined peptide MHC (pMHC) characterization and discovery of potential novel therapeutic leads.

• Risnes, Louise Fremgaard; Christophersen, Asbjørn; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Sandve, Geir Kjetil; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Qiao, Shuo Wang & Sollid, Ludvig Magne (2018). Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease. Journal of Clinical Investigation.  ISSN 0021-9738.  128(6), s 2642- 2650 . doi: 10.1172/JCI98819 Fulltekst i vitenarkiv.
• Shao, Wenguang; Pedrioli, Patrick G.A.; Wolski, Witold; Scurtescu, Cristian; Schmid, Emanuel; Vizcaíno, Juan Antonio; Courcelles, Mathieu; Schuster, Heiko; Kowalewski, Daniel; Marino, Fabio; Arlehamn, Cecilia S.L.; Vaughan, Kerrie; Peters, Bjoern; Sette, Alessandro; Ottenhoff, Tom H.M.; Meijgaarden, Krista E.; Nieuwenhuizen, Natalie; Kaufmann, Stefan H.E.; Schlapbach, Ralph; Castle, John C.; Nesvizhskii, Alexey I.; Nielsen, Morten; Deutsch, Eric W.; Campbell, David S.; Moritz, Robert L.; Zubarev, Roman A.; Ytterberg, Anders Jimmy; Purcell, Anthony W.; Marcilla, Miguel; Paradela, Alberto; Wang, Qi; Costello, Catherine E.; Ternette, Nicola; van Veelen, Peter A.; van Els, Cécile A.C.M.; Heck, Albert J.R.; De Souza, Gustavo Antonio; Sollid, Ludvig Magne; Admon, Arie; Stevanovic, Stefan; Rammensee, Hans-Georg; Thibault, Pierre; Perreault, Claude; Bassani-Sternberg, Michal; Aebersold, Ruedi & Caron, Etienne (2018). The SysteMHC Atlas project. Nucleic Acids Research.  ISSN 0305-1048.  46(1), s D1237- D1247 . doi: 10.1093/nar/gkx664 Fulltekst i vitenarkiv. Vis sammendrag

  Mass spectrometry (MS)-based immunopeptidomics investigates the repertoire of peptides presented at the cell surface by major histocompatibility complex (MHC) molecules. The broad clinical relevance of MHC-associated peptides, e.g. in precision medicine, provides a strong rationale for the large-scale generation of immunopeptidomic datasets and recent developments in MS-based peptide analysis technologies now support the generation of the required data. Importantly, the availability of diverse immunopeptidomic datasets has resulted in an increasing need to standardize, store and exchange this type of data to enable better collaborations among researchers, to advance the field more efficiently and to establish quality measures required for the meaningful comparison of datasets. Here we present the SysteMHC Atlas (https://systemhcatlas.org), a public database that aims at collecting, organizing, sharing, visualizing and exploring immunopeptidomic data generated by MS. The Atlas includes raw mass spectrometer output files collected from several laboratories around the globe, a catalog of contextspecific datasets ofMHC class I and class II peptides, standardized MHC allele-specific peptide spectral libraries consisting of consensus spectra calculated from repeat measurements of the same peptide sequence, and links to other proteomics and immunology databases. The SysteMHC Atlas project was created and will be further expanded using a uniform and open computational pipeline that controls the quality of peptide identifications and peptide annotations. Thus, the SysteMHC Atlas disseminates quality controlled immunopeptidomic information to the public domain and serves as a community resource toward the generation of a high-quality comprehensive map of the human immunopeptidome and the support of consistent measurement of immunopeptidomic sample cohorts.

• Tutturen, Astrid Elisabeth Voorham; Dørum, Siri; Clancy, Trevor; Reims, Henrik Mikael; Christophersen, Asbjørn; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne; De Souza, Gustavo Antonio & Stamnæs, Jorunn (2018). Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry. American Journal of Pathology.  ISSN 0002-9440.  188(7), s 1563- 1579 . doi: 10.1016/j.ajpath.2018.03.017 Fulltekst i vitenarkiv.
• Cardoso, Ines Do Rosario; Østerlund, Eva Christina; Stamnæs, Jorunn; Iversen, Rasmus; Andersen, Jan Terje; Jørgensen, Thomas J D & Sollid, Ludvig Magne (2017). Dissecting the interaction between transglutaminase 2 and fibronectin. Amino Acids.  ISSN 0939-4451.  49(3), s 489- 500 . doi: 10.1007/s00726-016-2296-y Fulltekst i vitenarkiv.
• Goel, Gautam; King, Tim; Daveson, A. James; Andrews, Jane M.; Krishnarajah, Janakan; Krause, Richard; Brown, Gregor J.E.; Fogel, Ronald; Barish, Charles F.; Epstein, Roger; Kinney, Timothy P.; Miner, Philip B.; Tye-Din, Jason A.; Girardin, Adam; Taavela, Juha; Popp, Alina; Sidney, John; Mäki, Markku; Goldstein, Kaela E.; Griffin, Patrick H.; Wang, Suyue; Dzuris, John L.; Williams, Leslie J.; Sette, Alessandro; Xavier, Ramnik J.; Sollid, Ludvig Magne; Jabri, Bana & Anderson, Robert P. (2017). Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies. The Lancet Gastroenterology and Hepatology.  ISSN 2468-1253.  2(7), s 479- 493 . doi: 10.1016/S2468-1253(17)30110-3 Fulltekst i vitenarkiv.
• Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Bergseng, Elin; Frigstad, Terje; Frick, Rahel; du Pré, Marie Fleur; Dalhus, Bjørn; Lundin, Knut Erik Aslaksen; Qiao, Shuo Wang; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2017). A TCRα framework–centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions. JCI Insight.  ISSN 2379-3708.  2(17) . doi: 10.1172/jci.insight.95193 Fulltekst i vitenarkiv.
• Iversen, Rasmus; Snir, Omri; Stensland, Maria; Kroll, José E.; Steinsbø, Øyvind; Korponay-Szabó, Ilma R.; Lundin, Knut Erik Aslaksen; De Souza, Gustavo Antonio & Sollid, Ludvig Magne (2017). Strong clonal relatedness between serum and gut IgA despite different plasma cell origins. Cell reports.  ISSN 2211-1247.  20(10), s 2357- 2367 . doi: 10.1016/j.celrep.2017.08.036 Fulltekst i vitenarkiv.
• Jabri, Bana & Sollid, Ludvig Magne (2017). T cells in celiac disease. Journal of Immunology.  ISSN 0022-1767.  198(8), s 3005- 3014 . doi: 10.4049/jimmunol.1601693
• Landsverk, Ole J. B.; Snir, Omri; Bartolome Casado, Raquel; Richter, Lisa Maria; Mold, Jeff E.; Réu, Pedro; Horneland, Rune; Paulsen, Vemund; Yaqub, Sheraz; Aandahl, Einar Martin; Øyen, Ole; Thorarensen, Hildur Sif; Salehpour, Mehran; Possnert, Göran; Frisén, Jonas; Sollid, Ludvig Magne; Bækkevold, Espen Sønderaal & Jahnsen, Frode Lars (2017). Antibody-secreting plasma cells persist for decades in human intestine. Journal of Experimental Medicine.  ISSN 0022-1007.  214(2), s 309- 317 . doi: 10.1084/jem.20161590 Fulltekst i vitenarkiv.
• Nguyen, Thanh-Binh; Jayaraman, Priya; Bergseng, Elin; Madhusudhan, M.S.; Kim, Chu-Young & Sollid, Ludvig Magne (2017). Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-Associated invariant chain peptides. Journal of Biological Chemistry.  ISSN 0021-9258.  292(22), s 9218- 9228 . doi: 10.1074/jbc.M117.785139
• Raki, Melinda; Dahal-Koirala, Shiva; Yu, Hao; Korponay-Szabó, Ilma R.; Gyimesi, Judit; Castillejo, Gemma; Jahnsen, Jørgen; Qiao, Shuo Wang & Sollid, Ludvig Magne (2017). Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes. Gastroenterology.  ISSN 0016-5085.  153(3), s 787- 798.e4 . doi: 10.1053/j.gastro.2017.05.016
• Roy, Bishnudeo; Neumann, Ralf Stefan; Snir, Omri; Iversen, Rasmus; Sandve, Geir Kjetil; Lundin, Knut Erik Aslaksen & Sollid, Ludvig Magne (2017). High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease. Journal of Immunology.  ISSN 0022-1767.  199((2)), s 782- 791 . doi: 10.4049/jimmunol.1700169 Fulltekst i vitenarkiv.
• Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Mørkrid, Lars; Qiao, Shuo Wang; Sollid, Ludvig Magne & Christophersen, Asbjørn (2017). HLA-DQ-gluten tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption. Gastroenterology.  ISSN 0016-5085.  154(4), s 886- 896.e6 . doi: 10.1053/j.gastro.2017.11.006 Fulltekst i vitenarkiv.
• Sarna, Vikas Kumar; Skodje, Gry Irene; Reims, Henrik Mikael; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva; Sollid, Ludvig Magne & Lundin, Knut Erik Aslaksen (2017). HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge. Gut.  ISSN 0017-5749.  67(9), s 1606- 1613 . doi: 10.1136/gutjnl-2017-314461 Fulltekst i vitenarkiv.
• Snir, Omri; Chen, Xi; Gidoni, Moriah; du Pré, Marie Fleur; Zhao, Yuguang; Steinsbø, Øyvind; Lundin, Knut Erik Aslaksen; Yaari, Gur & Sollid, Ludvig Magne (2017). Stereotyped antibody responses target posttranslationally modified gluten in celiac disease. JCI Insight.  ISSN 2379-3708.  2(16) . doi: 10.1172/jci.insight.93961 Fulltekst i vitenarkiv.
• Sollid, Ludvig Magne (2017). The roles of MHC class II genes and post-translational modification in celiac disease. Immunogenetics.  ISSN 0093-7711.  69(8-9), s 605- 616 . doi: 10.1007/s00251-017-0985-7 Fulltekst i vitenarkiv.
• Viken, Marte K; Flåm, Siri Tennebø; Skrivarhaug, Torild; Amundsen, Silja Svanstrøm; Sollid, Ludvig Magne; Drivvoll, Ann Kristin; Joner, Geir; Dahl-Jørgensen, Knut & Lie, Benedicte Alexandra (2017). HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease. HLA.  ISSN 2059-2302.  89(5), s 278- 284 . doi: 10.1111/tan.12986
• Christophersen, Asbjørn; Risnes, Louise Fremgaard; Bergseng, Elin; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2016). Healthy HLA-DQ2.5<sup>+</sup> subjects lack regulatory and memory T cells specific for immunodominant gluten epitopes of celiac disease. Journal of Immunology.  ISSN 0022-1767.  196(6), s 2819- 2826 . doi: 10.4049/jimmunol.1501152
• Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Christophersen, Asbjørn; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2016). TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage. Mucosal Immunology.  ISSN 1935-3456.  9(3), s 587- 596 . doi: 10.1038/mi.2015.147 Fulltekst i vitenarkiv.
• De Niro, R; Snir, Omri; Kaukinen, Katri; Yaari, Gur; Lundin, Knut Erik Aslaksen; Gupta, N; Kleinstein, H; Cols, M; Cerutti, A; Mäki, M; Shlomchik, Mark J & Sollid, Ludvig Magne (2016). Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease. Mucosal Immunology.  ISSN 1935-3456.  9, s 254- 264 . doi: 10.1038/mi.2015.57
• Dørum, Siri; Steinsbø, Øyvind; Bergseng, Elin; Arntzen, Magnus Øverlie; De Souza, Gustavo Antonio & Sollid, Ludvig Magne (2016). Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep25565 Fulltekst i vitenarkiv.
• Hnida, Kathrin; Stamnæs, Jorunn; du Pré, Marie Fleur; Mysling, Simon; Jørgensen, Thomas J D; Sollid, Ludvig Magne & Iversen, Rasmus (2016). Epitope-dependent functional effects of celiac disease autoantibodies on transglutaminase 2. Journal of Biological Chemistry.  ISSN 0021-9258.  291(49), s 25542- 25552 . doi: 10.1074/jbc.M116.738161
• Høydahl, Lene Støkken; Nilssen, Nicolay Rustad; Gunnarsen, Kristin Støen; du Pré, Marie Fleur; Iversen, Rasmus; Roos, Norbert; Chen, Xi; Michaelsen, Terje Einar; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2016). Multivalent pIX phage display selects for distinct and improved antibody properties. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep39066 Fulltekst i vitenarkiv.
• Riaz, Tahira; Sollid, Ludvig Magne; Olsen, Ingrid & De Souza, Gustavo Antonio (2016). Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells. Molecular & Cellular Proteomics.  ISSN 1535-9476.  15(3), s 1007- 1016 . doi: 10.1074/mcp.M115.050138
• Spencer, Jo M. & Sollid, Ludvig Magne (2016). The human intestinal B-cell response. Mucosal Immunology.  ISSN 1935-3456.  9(5), s 1113- 1124 . doi: 10.1038/mi.2016.59
• Stamnæs, Jorunn; Cardoso, Ines Do Rosario; Iversen, Rasmus & Sollid, Ludvig Magne (2016). Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C-terminal beta-barrel domain. The FEBS Journal.  ISSN 1742-464X.  283(21), s 3994- 4010 . doi: 10.1111/febs.13907
• Bergseng, Elin; Dørum, Siri; Arntzen, Magnus; Nielsen, Morten; Nygård, Ståle; Buus, Søren; De Souza, Gustavo Antonio & Sollid, Ludvig Magne (2015). Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires. Immunogenetics.  ISSN 0093-7711.  67(2), s 73- 84 . doi: 10.1007/s00251-014-0819-9
• Cardoso, Ines Do Rosario; Stamnæs, Jorunn; Andersen, Jan Terje; Melino, Gerry; Iversen, Rasmus & Sollid, Ludvig Magne (2015). Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies. The FEBS Journal.  ISSN 1742-464X.  s 2063- 2075 . doi: 10.1111/febs.13276
• Cardoso, Ines Do Rosario; Stamnæs, Jorunn; Andersen, Jan Terje; Melino, Gerry; Iversen, Rasmus & Sollid, Ludvig Magne (2015). Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies. The FEBS Journal.  ISSN 1742-464X.  282(11), s 2063- 2075 . doi: 10.1111/febs.13276
• du Pré, Fleur & Sollid, Ludvig Magne (2015). T-cell and B-cell immunity in celiac disease. Baillière's Best Practice & Research : Clinical Gastroenterology.  ISSN 1521-6918.  29(3), s 413- 423 . doi: 10.1016/j.bpg.2015.04.001
• Iversen, Rasmus; Fleur du Pre, Marie; Di Niro, Roberto & Sollid, Ludvig Magne (2015). Igs as substrates for transglutaminase 2: Implications for autoantibody production in celiac disease. Journal of Immunology.  ISSN 0022-1767.  195(11), s 5159- 5168 . doi: 10.4049/jimmunol.1501363 Fulltekst i vitenarkiv. Vis sammendrag

  Autoantibodies specific for the enzyme transglutaminase 2 (TG2) are a hallmark of the gluten-sensitive enteropathy celiac disease. Production of the Abs is strictly dependent on exposure to dietary gluten proteins, thus raising the question how a foreign Ag (gluten) can induce an autoimmune response. It has been suggested that TG2-reactive B cells are activated by gluten-reactive T cells following receptor-mediated uptake of TG2-gluten complexes. In this study, we propose a revised model that is based on the ability of the BCR to serve as a substrate to TG2 and become cross-linked to gluten-derived peptides. We show that TG2-specific IgD molecules are preferred in the reaction and that binding of TG2 via a common epitope targeted by cells using the IgH variable gene segment (IGHV)5-51 results in more efficient cross-linking. Based on these findings we hypothesize that IgD-expressing B cells using IGHV5-51 are preferentially activated, and we suggest that this property can explain the previously reported low number of somatic mutations as well as the overrepresentation of IGHV5-51 among TG2-specific plasma cells in the celiac lesion. The model also couples gluten peptide uptake by TG2-reactive B cells directly to peptide deamidation, which is necessary for the activation of gluten-reactive T cells. It thereby provides a link between gluten deamidation, T cell activation, and the production of TG2-specific Abs. These are all key events in the development of celiac disease, and by connecting them the model may explain why the same enzyme that catalyzes gluten deamidation is also an autoantigen, something that is hardly coincidental

• Lundin, Knut E A; Qiao, Shuo Wang; Snir, Omri & Sollid, Ludvig Magne (2015). Coeliac disease-from genetic and immunological studies to clinical applications. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  50(6), s 708- 717 . doi: 10.3109/00365521.2015.1030766
• Snir, Omri; Mesin, Luka; Gidoni, Moriah; Lundin, Knut E A; Yaari, Gur & Sollid, Ludvig Magne (2015). Analysis of celiac disease autoreactive gut plasma cells and their corresponding memory compartment in peripheral blood using high-throughput sequencing. Journal of Immunology.  ISSN 0022-1767.  194(12), s 5703- 5712 . doi: 10.4049/jimmunol.1402611
• Sollid, Ludvig Magne; Iversen, Rasmus; Steinsbø, Øyvind; Qiao, Shuo Wang; Bergseng, Elin; Dørum, Siri; du Pré, Fleur; Stamnæs, Jorunn; Christophersen, Asbjørn; Cardoso, Ines Do Rosario; Hnida, Kathrin; Xi, Chien; Snir, Omri & Lundin, Knut E A (2015). Small bowel, celiac disease and adaptive immunity. Digestive Diseases.  ISSN 0257-2753.  33(2), s 115- 121 . doi: 10.1159/000369512
• Stamnæs, Jorunn; Iversen, Rasmus; Fleur du Pre, Marie; Xi, Chien & Sollid, Ludvig Magne (2015). Enhanced B-cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization. PLoS ONE.  ISSN 1932-6203.  10:e0134922(8) . doi: 10.1371/journal.pone.0134922
• Stamnæs, Jorunn & Sollid, Ludvig Magne (2015). Celiac disease: Autoimmunity in response to food antigen. Seminars in Immunology.  ISSN 1044-5323.  27(5), s 343- 352 . doi: 10.1016/j.smim.2015.11.001
• Steinsbø, Øyvind; Dørum, Siri; Lundin, Knut Erik Aslaksen & Sollid, Ludvig Magne (2015). Serologic assay for diagnosis of celiac disease based on a patient-derived monoclonal antigliadin antibody. Gastroenterology.  ISSN 0016-5085.  149(6), s 1530- 1540.e3 . doi: 10.1053/j.gastro.2015.07.008
• Xi, Chien; Hnida, Kathrin; Graewert, Melissa Ann; Andersen, Jan Terje; Iversen, Rasmus; Tuukkanen, Anne; Svergun, Dmitri & Sollid, Ludvig Magne (2015). Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease. Journal of Biological Chemistry.  ISSN 0021-9258.  290(35), s 21365- 21375 . doi: 10.1074/jbc.M115.669895
• Amundsen, Svanstrøm Silja; Viken, Marte K; Sollid, Ludvig Magne & Lie, Benedicte Alexandra (2014). Coeliac disease-associated polymorphisms influence thymic gene expression. Genes and Immunity.  ISSN 1466-4879.  15(6), s 355- 360 . doi: 10.1038/gene.2014.26
• Christophersen, Asbjørn; Raki, Melinda; Bergseng, Elin; Lundin, Knut E A; Jahnsen, Jørgen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2014). Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge. United European Gastroenterology journal.  ISSN 2050-6406.  2(4), s 268- 278 . doi: 10.1177/2050640614540154
• Dørum, Siri; Bodd, Michael; Fallang, Lars-Egil; Bergseng, Elin; Christophersen, Asbjørn; Johansen, Marie Kongshaug; Qiao, Shuo Wang; Stamnæs, Jorunn; De Souza, Gustavo Antonio & Sollid, Ludvig Magne (2014). HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes. Journal of Immunology.  ISSN 0022-1767.  193(9), s 4497- 4506 . doi: 10.4049/jimmunol.1301466
• Iversen, Rasmus; Mysling, Simon; Hnida, Kathrin; Jørgensen, Thomas J D & Sollid, Ludvig Magne (2014). Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  111(48), s 17146- 17151 . doi: 10.1073/pnas.1407457111 Fulltekst i vitenarkiv.
• Lundin, Knut E A & Sollid, Ludvig Magne (2014). Advances in coeliac disease. Current Opinion in Gastroenterology.  ISSN 0267-1379.  30(2), s 154- 162 . doi: 10.1097/MOG.0000000000000041
• Qiao, Shuo Wang; Christophersen, Asbjørn; Lundin, Knut E A & Sollid, Ludvig Magne (2014). Biased usage and preferred pairing of α-and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease. International Immunology.  ISSN 0953-8178.  26(1), s 13- 19 . doi: 10.1093/intimm/dxt037
• Sollid, Ludvig Magne; Pos, Wouter & Wucherpfennig, Kai (2014). Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Current Opinion in Immunology.  ISSN 0952-7915.  31, s 24- 30 . doi: 10.1016/j.coi.2014.08.005
• Steinsbø, Øyvind; Dunand, Carole J.Henry; Huang, Min; Mesin, Luka; Salgado-Ferrer, Marlene; Lundin, Knut E A; Jahnsen, Jørgen; Wilson, Patrick C. & Sollid, Ludvig Magne (2014). Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells. Nature Communications.  ISSN 2041-1723.  5 . doi: 10.1038/ncomms5041
• Toft-Hansen, Henrik; Rasmussen, Karina S.; Staal, Anne; Roggen, Erwin L.; Sollid, Ludvig Magne; Lillevang, Søren T.; Barington, Torben & Husby, Steffen (2014). Treatment of both native and deamidated gluten peptides with an endo-peptidase from Aspergillus niger prevents stimulation of gut-derived gluten-reactive T cells from either children or adults with celiac disease. Clinical Immunology.  ISSN 1521-6616.  153(2), s 323- 331 . doi: 10.1016/j.clim.2014.05.009
• Bodd, Michael; Raki, Melinda; Bergseng, Elin; Jahnsen, Jørgen; Lundin, Knut E A & Sollid, Ludvig Magne (2013). Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease. European Journal of Immunology.  ISSN 0014-2980.  43(10), s 2605- 2612 . doi: 10.1002/eji.201343382
• Brottveit, Margit; Røberg Beitnes, Ann-Christin; Tollefsen, Stig; Bratlie, Jorunn; Jahnsen, Frode Lars; Johansen, Finn Eirik; Sollid, Ludvig Magne & Lundin, Knut E A (2013). Mucosal Cytokine Response After Short-Term Gluten Challenge in Celiac Disease and Non-Celiac Gluten Sensitivity. American Journal of Gastroenterology.  ISSN 0002-9270.  108(5), s 842- 850 . doi: 10.1038/ajg.2013.91
• Iversen, Rasmus; Di Niro, Roberto; Stamnæs, Jorunn; Lundin, Knut E A; Wilson, Patric C. & Sollid, Ludvig Magne (2013). Transglutaminase 2-Specific Autoantibodies in Celiac Disease Target Clustered, N-Terminal Epitopes Not Displayed on the Surface of Cells. Journal of Immunology.  ISSN 0022-1767.  190(12), s 5981- 5991 . doi: 10.4049/jimmunol.1300183 Fulltekst i vitenarkiv.
• Olsen, Ingrid; Lundin, Knut E A & Sollid, Ludvig Magne (2013). Increased frequency of intestinal CD4(+) T cells reactive with mycobacteria in patients with Crohn's disease. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  48(11), s 1278- 1285 . doi: 10.3109/00365521.2013.837952
• Olsen, Ingrid & Sollid, Ludvig Magne (2013). Pitfalls in determining the cytokine profile of human T cells. JIM - Journal of Immunological Methods.  ISSN 0022-1759.  390(1-2), s 106- 112 . doi: 10.1016/j.jim.2013.01.015
• Raki, Melinda; Røberg Beitnes, Ann-Christin; Lundin, Knut E A; Jahnsen, Jørgen; Jahnsen, Frode Lars & Sollid, Ludvig Magne (2013). Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion. Mucosal Immunology.  ISSN 1935-3456.  6, s 985- 992 . doi: 10.1038/mi.2012.136
• Sollid, Ludvig Magne & Jabri, Bana (2013). Triggers and drivers of autoimmunity: lessons from coeliac disease. Nature reviews. Immunology.  ISSN 1474-1733.  13(4), s 294- 302 . doi: 10.1038/nri3407
• Sollid, Ludvig Magne & Lundin, Knut E A (2013). Celiac Disease, In Noel Rose & Ian R. Mackay (ed.),  Autoimmune Diseases.  Elsevier.  ISBN 978-0-12-384929-8.  Kapittel 59.  s 855 - 871
• Bodd, Michael; Kim, Chu-Young; Lundin, Knut E A & Sollid, Ludvig Magne (2012). T-Cell Response to Gluten in Patients With HLA-DQ2.2 Reveals Requirement of Peptide-MHC Stability in Celiac Disease. Gastroenterology.  ISSN 0016-5085.  142(3), s 552- 561 . doi: 10.1053/j.gastro.2011.11.021
• Bodd, Michael; Tollefsen, Stig; Bergseng, Elin; Lundin, Knut E A & Sollid, Ludvig Magne (2012). Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells. Human Immunology.  ISSN 0198-8859.  73(4), s 376- 381 . doi: 10.1016/j.humimm.2012.01.016
• Dafik, Laila; Albertelli, Megan; Stamnæs, Jorunn; Sollid, Ludvig Magne & Khosla, Chaitan (2012). Activation and Inhibition of Transglutaminase 2 in Mice. PLoS ONE.  ISSN 1932-6203.  7(2) . doi: 10.1371/journal.pone.0030642
• Di Niro, Roberto; Mesin, Luka; Zheng, Nai-Ying; Stamnæs, Jorunn; Morrissey, Michael; Lee, Jane-Hwei; Huang, Min; Iversen, Rasmus; du Pré, Fleur; Qiao, Shuo Wang; Lundin, Knut E A; Wilson, Patric C. & Sollid, Ludvig Magne (2012). High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nature Medicine.  ISSN 1078-8956.  18(3), s 441- U204 . doi: 10.1038/nm.2656
• Mesin, Luka; Sollid, Ludvig Magne & Di Niro, Roberto (2012). The intestinal B-cell response in celiac disease. Frontiers in Immunology.  ISSN 1664-3224. . doi: 10.3389/fimmu.2012.00313
• Pollmann, Sylvie Mireille; Stensland, Maria; Halvorsen, Eirik Hornes; Sollid, Ludvig Magne; Kvien, Tore Kristian; Fleckenstein, Burkhard & Molberg, Øyvind (2012). Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate. Rheumatology International.  ISSN 0172-8172.  32(5), s 1271- 1276 . doi: 10.1007/s00296-010-1765-y
• Qiao, Shuo Wang; Iversen, Rasmus; Raki, Melinda & Sollid, Ludvig Magne (2012). The adaptive immune response in celiac disease. Springer Seminars in Immunopathology.  ISSN 0344-4325.  34(4), s 523- 540 . doi: 10.1007/s00281-012-0314-z
• Røberg Beitnes, Ann-Christin; Raki, Melinda; Brottveit, Margit; Lundin, Knut E A; Jahnsen, Frode Lars & Sollid, Ludvig Magne (2012). Rapid Accumulation of CD14(+)CD11c(+) Dendritic Cells in Gut Mucosa of Celiac Disease after in vivo Gluten Challenge. PLoS ONE.  ISSN 1932-6203.  7(3) . doi: 10.1371/journal.pone.0033556
• Sollid, Ludvig Magne; Qiao, Shuo Wang; Anderson, Robert P; Gianfrani, Carmen & Koning, Frits (2012). Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules. Immunogenetics.  ISSN 0093-7711.  64(6), s 455- 460 . doi: 10.1007/s00251-012-0599-z
• Tollefsen, Stig; Hotta, Kinya; Chen, Xi; Simonsen, Bjørg; Swaminathan, Kunchithapadam; Mathews, Irimpan I; Sollid, Ludvig Magne & Kim, Chu-Young (2012). Structural and Functional Studies of trans-Encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) Protein Molecule. Journal of Biological Chemistry.  ISSN 0021-9258.  287(17), s 13611- 13619 . doi: 10.1074/jbc.M111.320374
• Abadie, Valérie; Sollid, Ludvig Magne; Barreiro, Luis B. & Jabri, Bana (2011). Integration of Genetic and Immunological Insights into a Model of Celiac Disease Pathogenesis. Annual Review of Immunology.  ISSN 0732-0582.  29, s 493- 525 . doi: 10.1146/annurev-immunol-040210-092915
• Brottveit, Margit; Raki, Melinda; Bergseng, Elin; Fallang, Lars-Egil; Simonsen, Bjørg; Løvik, Astrid; Larsen, Stig; Løberg, Else Marit; Jahnsen, Frode Lars; Sollid, Ludvig Magne & Lundin, Knut E A (2011). Assessing possible celiac disease by an HLA-DQ2-gliadin tetramer test. American Journal of Gastroenterology.  ISSN 0002-9270.  106(7), s 1318- 1324 . doi: 10.1038/ajg.2011.23
• du Pré, M. Fleur; Kozijn, Anne E.; van Berkel, Lisette A.; ter Borg, Mariëtte N. D.; Lindenbergh-Kortleve, Dicky; Jensen, Lise Torp; Kooy-Winkelaar, Yvonne; Koning, Frits; Boon, Louis; Nieuwenhuis, Edward E. S.; Sollid, Ludvig Magne; Fugger, Lars & Samsom, Janneke N. (2011). Tolerance to Ingested Deamidated Gliadin in Mice is Maintained by Splenic, Type 1 Regulatory T Cells. Gastroenterology.  ISSN 0016-5085.  141(2), s 610- U714 . doi: 10.1053/j.gastro.2011.04.048
• du Pré, M. Fleur; van Berkel, Lisette A.; Raki, Melinda; van Leeuwen, Marieke A.; de Ruiter, Lilian F.; Broere, Femke; ter Borg, Mariëtte N. D.; Lund, Frances E.; Escher, Johanna C.; Lundin, Knut E A; Sollid, Ludvig Magne; Kraal, Georg; Nieuwenhuis, Edward E. S. & Samsom, Janneke N. (2011). CD62L(neg)CD38(+) Expression on Circulating CD4(+) T Cells Identifies Mucosally Differentiated Cells in Protein Fed Mice and in Human Celiac Disease Patients and Controls. American Journal of Gastroenterology.  ISSN 0002-9270.  106(6), s 1147- 1159 . doi: 10.1038/ajg.2011.24
• Halvorsen, Eirik Hornes; Strønen, Erlend; Hammer, Hilde Berner; Goll, Guro Løvik; Sollid, Ludvig Magne & Molberg, Øyvind (2011). Interleukin-15 Induces Interleukin-17 Production by Synovial T Cell Lines from Patients with Rheumatoid Arthritis. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(3), s 243- 249 . doi: 10.1111/j.1365-3083.2010.02498.x
• Jin, Xi; Stamnæs, Jorunn; Klock, Cornelius; DiRaimondo, Thomas R.; Sollid, Ludvig Magne & Khosla, Chaitan (2011). Activation of Extracellular Transglutaminase 2 by Thioredoxin. Journal of Biological Chemistry.  ISSN 0021-9258.  286(43), s 37866- 37873 . doi: 10.1074/jbc.M111.287490
• Juse, Ulrike; Arntzen, Magnus; Højrup, Peter; Fleckenstein, Burkhard & Sollid, Ludvig Magne (2011). Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  19(7), s 2470- 2477 . doi: 10.1016/j.bmc.2011.01.057
• Mesin, Luka; Di Niro, Roberto; Thompson, Keith M; Lundin, Knut E A & Sollid, Ludvig Magne (2011). Long-Lived Plasma Cells from Human Small Intestine Biopsies Secrete Immunoglobulins for Many Weeks In Vitro. Journal of Immunology.  ISSN 0022-1767.  187(6), s 2867- 2874 . doi: 10.4049/jimmunol.1003181
• Qiao, Shuo Wang; Raki, Melinda; Gunnarsen, Kristin Støen; Løset, Geir Åge; Lundin, Knut E A; Sandlie, Inger & Sollid, Ludvig Magne (2011). Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease. Journal of Immunology.  ISSN 0022-1767.  187(6), s 3064- 3071 . doi: 10.4049/jimmunol.1101526
• Røberg Beitnes, Ann-Christin; Raki, Melinda; Lundin, Knut E A; Jahnsen, Jørgen; Sollid, Ludvig Magne & Jahnsen, Frode Lars (2011). Density of CD163(+)CD11c(+) Dendritic Cells Increases and CD103(+) Dendritic Cells Decreases in the Coeliac Lesion. Scandinavian Journal of Immunology.  ISSN 0300-9475.  74(2), s 186- 194 . doi: 10.1111/j.1365-3083.2011.02549.x
• Sollid, Ludvig Magne & Jabri, Bana (2011). Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders. Current Opinion in Immunology.  ISSN 0952-7915.  23(6), s 732- 738 . doi: 10.1016/j.coi.2011.08.006 Vis sammendrag

  Posttranslational modification (PTM) of antigen is a way to break T-cell tolerance to self-antigens and promote autoimmunity. However, the precise mechanisms by which modifications would facilitate autoimmune T-cell responses and how they relate to particular autoimmune-associated MHC molecules remain elusive. Celiac disease is a T-cell mediated enteropathy with a strong HLA association where the immune response is directed mainly against deamidated cereal gluten peptides that have been modified by the enzyme transglutaminase 2. The disease is further characterized by autoantibodies to transglutaminase 2 that have extraordinary high disease specificity and sensitivity. There have been important advances in the knowledge of celiac disease pathogenesis, and these insights may be applicable to other autoimmune disorders where PTM plays a role. This insight gives clues for understanding the involvement of PTMs in other autoimmune diseases.

• Sollid, Ludvig Magne & Khosla, C. (2011). Novel therapies for coeliac disease. Journal of Internal Medicine.  ISSN 0954-6820.  269(6), s 604- 613 . doi: 10.1111/j.1365-2796.2011.02376.x
• Dørum, Siri; Arntzen, Magnus; Qiao, Shuo Wang; Holm, Anders; Koehler, Christian; Thiede, Bernd; Sollid, Ludvig Magne & Fleckenstein, Burkhard (2010). The Preferred Substrates for Transglutaminase 2 in a Complex Wheat Gluten Digest Are Peptide Fragments Harboring Celiac Disease T-Cell Epitopes. PLoS ONE.  ISSN 1932-6203.  5(11) . doi: 10.1371/journal.pone.0014056 Vis sammendrag

  Conclusion: TG2 as well as gastrointestinal proteolysis play important roles in the selection of gluten T-cell epitopes in celiac disease.

• Stamnæs, Jorunn; Dørum, Siri; Fleckenstein, Burkhard; Aeschlimann, Daniel P & Sollid, Ludvig Magne (2010). Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia. Amino Acids.  ISSN 0939-4451.  39(5), s 1183- 1191 . doi: 10.1007/s00726-010-0554-y
• Amundsen, Svanstrøm Silja; Rundberg, J; Adamovic, S; Gudjònsdòttir, Audur H; Ascher, H; Ek, Johan; Nilsson, S; Lie, Benedicte Alexandra; Naluai, Å.T. & Sollid, Ludvig Magne (2010). Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort. Genes and Immunity.  ISSN 1466-4879.  11(1), s 79- 86 . doi: 10.1038/gene.2009.67
• Bodd, Michael; Raki, Melinda; Tollefsen, Stig; Fallang, Lars-Egil; Bergseng, Elin; Lundin, Katrin & Sollid, Ludvig Magne (2010). HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22. Mucosal Immunology Update.  ISSN 1068-7629.  3(6), s 594- 601 . doi: 10.1038/mi.2010.36
• Di Niro, Roberto; Mesin, Luka; Raki, Melinda; Zheng, Nai-Ying; Lund-Johansen, Fridtjof; Lundin, Knut E A; Charpilienne, Annie; Poncet, D.; Wilson, P.C. & Sollid, Ludvig Magne (2010). Rapid Generation of Rotavirus-Specific Human Monoclonal Antibodies from Small-Intestinal Mucosa. Journal of Immunology.  ISSN 0022-1767.  185(9), s 5377- 5383 . doi: 10.4049/jimmunol.1001587

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• Lindeman, Ida; Emerton, Guy; Mamanova, Lira; Snir, Omri; Polanski, Krzysztof; Qiao, Shuo Wang; Sollid, Ludvig Magne; Teichmann, Sarah A & Stubbington, Michael J. T. (2018). BraCeR: B-cell-receptor reconstruction and clonality inference from single-cell RNA-seq. Nature Methods.  ISSN 1548-7091.  15(8), s 563- 565 . doi: 10.1038/s41592-018-0082-3
• Sollid, Ludvig Magne & Lycke, Nils (2017). Per Brandtzaeg: patron of mucosal immunology. Mucosal Immunology.  ISSN 1935-3456.  10, s 1- 4 . doi: doi:10.1038/mi.2016.111
• Jabri, Bana; Chen, Xi & Sollid, Ludvig Magne (2014). How T cells taste gluten in celiac disease.. Nature Structural & Molecular Biology.  ISSN 1545-9993.  21, s 429- 431 . doi: 10.1038/nsmb.2826
• Sollid, Ludvig Magne & Jabri, Bana (2013). Celiac Disease, In Philip D Smith; Thomas T MacDonald & Richard S. Blumberg (ed.),  Principles of Mucosal Immunology. By Society for Mucosal Immunology.  Garland Science Publishing.  ISBN 978-0-8153-4443-8.  28.  s 431 - 455
• Sollid, Ludvig Magne & Villadangos, José A (2013). Editorial overview: Antigen processing. Current Opinion in Immunology.  ISSN 0952-7915.  25(1), s 71- 73 . doi: 10.1016/j.coi.2012.12.002
• Hou, Tieying; Qiao, Shuo Wang; Jin, Xi; Sidney, John; Sollid, Ludvig Magne; Macmillan, Henriette; Strohman, Michael; Yoon, Taejin & Mellins, Elizabeth (2012). Interaction of HLA-DM and HLA-DQ2 in antigen presentation: Implications for celiac disease association. Molecular Immunology.  ISSN 0161-5890.  51(1), s 40- 40 . doi: 10.1016/j.molimm.2012.03.005
• Hou, Tieying; Qiao, Shuo Wang; Jin, Xi; Sidney, John; Sollid, Ludvig Magne; Macmillan, Henriette; Strohman, Michael; Yoon, Taejin & Mellins, Elizabeth (2012). Interaction of HLA-DM and HLA-DQ2 in antigen presentation: Implications for celiac disease association. Molecular Immunology.  ISSN 0161-5890.  51(1), s 38- 38 . doi: 10.1016/j.molimm.2012.02.115
• Hou, Tieying; Qiao, Shuo Wang; Jin, Xi; Sidney, John; Sollid, Ludvig Magne & Mellins, Elizabeth (2012). Cryptic Fate of Gliadin Epitopes: Implication for Celiac Disease. Journal of Immunology.  ISSN 0022-1767.  188
• Viken, Marte K; Flåm, Siri Tennebø; Sollid, Ludvig Magne; Skrivarhaug, Torild; Dahl-Jørgensen, Knut & Lie, Benedicte Alexandra (2012). STUDY OF THE HLA-DRB1 AND-DQB1 GENES IN PATIENTS WITH COEXISTING TYPE 1 DIABETES AND CELIAC DISEASE. Tissue Antigens.  ISSN 0001-2815.  79(6), s 584- 584
• Bodd, Michael; Tollefsen, Stig; Lundin, Knut E A & Sollid, Ludvig Magne (2011). Gluten-Reactive T Cells in Patients with DQ2.2. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 369- 369
• Høydahl, Lene Støkken; Neumann, Ralf Stefan; Qiao, Shuo Wang; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2011). Development of a High Affinity TCR Reagent by Phage Display to Study Antigen Presentation in Celiac Disease. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 372- 372
• Iversen, Rasmus; Di Niro, Roberto; Wilson, Patric C. & Sollid, Ludvig Magne (2011). Mechanisms for Activation of Auto-Reactive B Cells in Response to Gluten Intake in Celiac Disease. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 354- 354
• Olsen, Ingrid; Lundin, Knut E A & Sollid, Ludvig Magne (2011). Searching for the secret of the T cells in Crohn’s disease.
• Qiao, Shuo Wang; Raki, Melinda; Gunnarsen, Kristin Støen; Løset, Geir Åge; Sandlie, Inger & Sollid, Ludvig Magne (2011). Post-Translational Modification of Gluten Shapes the T Cell Response in Coeliac Disease by Direct Interaction with the T Cell Receptor. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 356- 356
• Fleckenstein, Burkhard; Tutturen, Astrid Elisabeth Voorham; Holm, Anders; Kvien, Tore Kristian; Molberg, Øyvind & Sollid, Ludvig Magne (2010). An Approach to Identify Proteins Recognized by Anti-Citrullinated Protein Antibodies in the Synovial Fluid of Rheumatoid Arthritis Patients. Scandinavian Journal of Immunology.  ISSN 0300-9475.  71(6), s 480- 481

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