Shuo-Wang Qiao

• Lindeman, Ida; Zhou, Chunyan; Eggesbø, Linn Margrethe; Miao, Chichau; Polak, Justyna; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Qiao, Shuo-Wang; Iversen, Rasmus & Sollid, Ludvig Magne (2021). Longevity, clonal relationship and transcriptional program of celiac disease-specific plasma cells. Journal of Experimental Medicine (JEM).  ISSN 0022-1007. . doi: 10.1084/jem.20200852
• van der Graaf, Adriaan; Zorro, Maria; Claringbould, Annique; Võsa, Urmo; Aguirre-Gamboa, Raul; Li, Chan; Mooiweer, Joram; Ricaño-Ponce, Isis; Borek, Zuzanna; Koning, Frits; Kooy-Winkelaar, Yvonne; Sollid, Ludvig Magne; Qiao, Shuo Wang; Kumar, Vinod; Li, Yang; Franke, Lude; Withoff, Sebo; Wijmenga, Tjitske Nienke (Cisca); Sanna, Serena & Jonkers, Iris (2021). Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease. Frontiers in Genetics.  ISSN 1664-8021.  11:562434, s 1- 16 . doi: 10.3389/fgene.2020.562434
• Croft, Naomi; Solbakken, Monica Hongrø; Brieuc, Marine Servane Ono; Jentoft, Sissel; Jakobsen, Kjetill Sigurd & Qiao, Shuo Wang (2020). Single-Cell Transcriptome Profiling of Immune Cell Repertoire of the Atlantic Cod Which Naturally Lacks the Major Histocompatibility Class II System. Frontiers in Immunology.  ISSN 1664-3224.  11 . doi: 10.3389/fimmu.2020.559555
• du Pré, Fleur; Blazevski, Jana; Dewan, Alisa Elinsdatter; Stamnæs, Jorunn; Kanduri, Srinivasa Kalyana Chakravarthi; Sandve, Geir Kjetil; Johannesen, Marie Kongshaug; Lindstad, Christian Borgen; Hnida, Kathrin; Fugger, Lars; Melino, Gerry; Qiao, Shuo-Wang & Sollid, Ludvig Magne (2020). B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2. Journal of Experimental Medicine (JEM).  ISSN 0022-1007.  217:e20190860.(2), s 1- 14 . doi: 10.1084/jem.20190860 Fulltekst i vitenarkiv.
• Sikkeland, Liv Ingunn Bjoner; Qiao, Shuo Wang; Ueland, Thor; Myrdal, Ole Henrik; Wyrozemski, Lukasz Adam; Aukrust, Pål; Jahnsen, Frode Lars; Sjåheim, Tone Bjørg; Kongerud, Johny; Molberg, Øyvind; (Samersaw-)Lund, May Brit & Bækkevold, Espen Sønderaal (2020). Lung CD4+ T cells in patients with lung fibrosis produce pro-fibrotic IL-13 together with IFNγ. European Respiratory Journal.  ISSN 0903-1936. . doi: 10.1183/13993003.00983-2020 Fulltekst i vitenarkiv.
• Ting, Yi Tian; Dahal-Koirala, Shiva; Kim, Hui Shi Keshia; Qiao, Shuo Wang; Neumann, Ralf Stefan; Lundin, Knut Erik Aslaksen; Petersen, Jan; Reid, Hugh H.; Sollid, Ludvig Magne & Rossjohn, Jamie (2020). A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  117(6), s 3063- 3073 . doi: 10.1073/pnas.1914308117 Fulltekst i vitenarkiv.
• Wyrozemski, Lukasz Adam; Sollid, Ludvig Magne & Qiao, Shuo Wang (2020). C-type lectin-like CD161 is not a co-signalling receptor in gluten-reactive CD4 + T cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  00:e13016, s 1- 9 . doi: 10.1111/sji.13016 Fulltekst i vitenarkiv.
• Bartolomé Casado, Raquel; Landsverk, Ole J. B.; Chauhan, Sudhir Kumar; Richter, Lisa Maria; Phung, Danh; Greiff, Victor; Risnes, Louise Fremgaard; Yao, Ying; Neumann, Ralf Stefan; Yaqub, Sheraz; Øyen, Ole; Horneland, Rune; Aandahl, Einar Martin; Paulsen, Vemund; Sollid, Ludvig Magne; Qiao, Shuo Wang; Bækkevold, Espen Sønderaal & Jahnsen, Frode Lars (2019). Resident memory CD8 T cells persist for years in human small intestine. Journal of Experimental Medicine (JEM).  ISSN 0022-1007.  216(10), s 2412- 2426 . doi: 10.1084/jem.20190414 Fulltekst i vitenarkiv.
• Goel, Gautam; Tye-Din, Jason A.; Qiao, Shuo Wang; Russell, Amy K.; Mayassi, Toufic; Ciszewski, Cezary; Sarna, Vikas Kumar; Wang, Suyue; Goldstein, Kaela E.; Dzuris, John L.; Williams, Leslie J.; Xavier, Ramnik J.; Lundin, Knut Erik Aslaksen; Jabri, Bana; Sollid, Ludvig Magne & Anderson, Robert P. (2019). Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. Indian Journal of Pure & Applied Physics.  ISSN 0019-5596.  5:eaaw7756(8), s 1- 15 . doi: 10.1126/sciadv.aaw7756 Fulltekst i vitenarkiv.
• Hung, Shu-Chen; Hou, Tieying; Jiang, Wei; Wang, Nan; Qiao, Shuo Wang; Chow, I-Ting; Liu, Xiaodan; van der Burg, Sjoerd H.; Koelle, David M; Kwok, William W; Sollid, Ludvig Magne & Mellins, Elizabeth D (2019). Epitope selection for HLA-DQ2 presentation: Implications for celiac disease and viral defense. Journal of Immunology.  ISSN 0022-1767.  202(9), s 2558- 2569 . doi: 10.4049/jimmunol.1801454
• Høydahl, Lene Støkken; Richter, Lisa Maria; Frick, Rahel; Snir, Omri; Gunnarsen, Kristin Støen; Landsverk, Ole J. B.; Iversen, Rasmus; Jeliazkov, Jeliazko R.; Gray, Jeffrey J.; Bergseng, Elin; Foss, Stian; Qiao, Shuo Wang; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Jahnsen, Frode Lars; Sandlie, Inger; Sollid, Ludvig Magne & Løset, Geir Åge (2019). Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease. Gastroenterology.  ISSN 0016-5085.  156(5), s 1428- 1439.e10 . doi: 10.1053/j.gastro.2018.12.013 Fulltekst i vitenarkiv.
• Qiao, Shuo Wang & Sollid, Ludvig Magne (2019). Two novel HLA-DQ2.5-restricted gluten T cell epitopes in the DQ2.5-glia-γ4 epitope family. Immunogenetics.  ISSN 0093-7711. . doi: 10.1007/s00251-019-01138-5
• Sollid, Ludvig Magne; Tye-Din, Jason A.; Qiao, Shuo Wang; Anderson, Robert; Gianfrani, Carmen & Koning, Frits (2019). Update 2020: nomenclature and listing of celiac disease - relevant gluten epitopes recognized by CD4+ T cells. Immunogenetics.  ISSN 0093-7711.  72(1-2), s 85- 88 . doi: 10.1007/s00251-019-01141-w Fulltekst i vitenarkiv.
• Dahal-Koirala, Shiva; Ciacchi, Laura; Petersen, Jan; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Christophersen, Asbjørn; Lundin, Knut Erik Aslaksen; Reid, Hugh H.; Qiao, Shuo Wang; Rossjohn, Jamie & Sollid, Ludvig Magne (2018). Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes. Journal of Biological Chemistry.  ISSN 0021-9258.  294(3), s 941- 952 . doi: 10.1074/jbc.RA118.005736 Fulltekst i vitenarkiv.
• Risnes, Louise Fremgaard; Christophersen, Asbjørn; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Sandve, Geir Kjetil; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Qiao, Shuo Wang & Sollid, Ludvig Magne (2018). Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease. Journal of Clinical Investigation.  ISSN 0021-9738.  128(6), s 2642- 2650 . doi: 10.1172/JCI98819 Fulltekst i vitenarkiv.
• Yao, Ying; Zia, Asima; Wyrozemski, Lukasz Adam; Lindeman, Ida; Sandve, Geir Kjetil & Qiao, Shuo Wang (2018). Exploiting antigen receptor information to quantify index switching in single-cell transcriptome sequencing experiments. PLOS ONE.  ISSN 1932-6203.  13(12), s 1- 17 . doi: 10.1371/journal.pone.0208484 Fulltekst i vitenarkiv.
• Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Bergseng, Elin; Frigstad, Terje; Frick, Rahel; du Pré, Marie Fleur; Dalhus, Bjørn; Lundin, Knut Erik Aslaksen; Qiao, Shuo Wang; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2017). A TCRα framework–centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions. JCI Insight.  ISSN 2379-3708.  2(17) . doi: 10.1172/jci.insight.95193 Fulltekst i vitenarkiv.
• Raki, Melinda; Dahal-Koirala, Shiva; Yu, Hao; Korponay-Szabó, Ilma R.; Gyimesi, Judit; Castillejo, Gemma; Jahnsen, Jørgen; Qiao, Shuo Wang & Sollid, Ludvig Magne (2017). Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes. Gastroenterology.  ISSN 0016-5085.  153(3), s 787- 798.e4 . doi: 10.1053/j.gastro.2017.05.016
• Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Mørkrid, Lars; Qiao, Shuo Wang; Sollid, Ludvig Magne & Christophersen, Asbjørn (2017). HLA-DQ-gluten tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption. Gastroenterology.  ISSN 0016-5085.  154(4), s 886- 896.e6 . doi: 10.1053/j.gastro.2017.11.006 Fulltekst i vitenarkiv.
• Christophersen, Asbjørn; Risnes, Louise Fremgaard; Bergseng, Elin; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2016). Healthy HLA-DQ2.5<sup>+</sup> subjects lack regulatory and memory T cells specific for immunodominant gluten epitopes of celiac disease. Journal of Immunology.  ISSN 0022-1767.  196(6), s 2819- 2826 . doi: 10.4049/jimmunol.1501152
• Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Christophersen, Asbjørn; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2016). TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage. Mucosal Immunology.  ISSN 1933-0219.  9(3), s 587- 596 . doi: 10.1038/mi.2015.147 Fulltekst i vitenarkiv.
• Lundin, Knut E A; Qiao, Shuo Wang; Snir, Omri & Sollid, Ludvig Magne (2015). Coeliac disease-from genetic and immunological studies to clinical applications. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  50(6), s 708- 717 . doi: 10.3109/00365521.2015.1030766
• Rath, Timo; Baker, Kristi; Dumont, Jennifer A.; Peters, Robert T.; Jiang, Haiyan; Qiao, Shuo Wang; Lencer, Wayne I.; Pierce, Glenn F. & Blumberg, Richard S. (2015). Fc-fusion proteins and FcRn: Structural insights for longer-lasting and more effective therapeutics. Critical Reviews in Biotechnology.  ISSN 0738-8551.  35(2), s 235- 254 . doi: 10.3109/07388551.2013.834293
• Sollid, Ludvig Magne; Iversen, Rasmus; Steinsbø, Øyvind; Qiao, Shuo Wang; Bergseng, Elin; Dørum, Siri; du Pré, Fleur; Stamnæs, Jorunn; Christophersen, Asbjørn; Cardoso, Ines Do Rosario; Hnida, Kathrin; Xi, Chien; Snir, Omri & Lundin, Knut E A (2015). Small bowel, celiac disease and adaptive immunity. Digestive Diseases.  ISSN 0257-2753.  33(2), s 115- 121 . doi: 10.1159/000369512
• Christophersen, Asbjørn; Raki, Melinda; Bergseng, Elin; Lundin, Knut E A; Jahnsen, Jørgen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2014). Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge. United European Gastroenterology journal.  ISSN 2050-6406.  2(4), s 268- 278 . doi: 10.1177/2050640614540154
• Dørum, Siri; Bodd, Michael; Fallang, Lars-Egil; Bergseng, Elin; Christophersen, Asbjørn; Johansen, Marie Kongshaug; Qiao, Shuo Wang; Stamnæs, Jorunn; De Souza, Gustavo Antonio & Sollid, Ludvig Magne (2014). HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes. Journal of Immunology.  ISSN 0022-1767.  193(9), s 4497- 4506 . doi: 10.4049/jimmunol.1301466
• Qiao, Shuo Wang; Christophersen, Asbjørn; Lundin, Knut E A & Sollid, Ludvig Magne (2014). Biased usage and preferred pairing of α-and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease. International Immunology.  ISSN 0953-8178.  26(1), s 13- 19 . doi: 10.1093/intimm/dxt037
• Rath, Timo; Kuo, Timothy T.; Baker, Kristi; Qiao, Shuo Wang; Kobayashi, Kanna; Yoshida, Masaru; Roopenian, Derry C; Fiebiger, Edda; Lencer, Wayne I. & Blumberg, Richard S. (2013). The Immunologic Functions of the Neonatal Fc Receptor for IgG. Journal of Clinical Immunology.  ISSN 0271-9142.  33, s S9- S17 . doi: 10.1007/s10875-012-9768-y
• Di Niro, Roberto; Mesin, Luka; Zheng, Nai-Ying; Stamnæs, Jorunn; Morrissey, Michael; Lee, Jane-Hwei; Huang, Min; Iversen, Rasmus; du Pré, Fleur; Qiao, Shuo Wang; Lundin, Knut E A; Wilson, Patric C. & Sollid, Ludvig Magne (2012). High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nature Medicine.  ISSN 1078-8956.  18(3), s 441- U204 . doi: 10.1038/nm.2656
• Qiao, Shuo Wang; Iversen, Rasmus; Raki, Melinda & Sollid, Ludvig Magne (2012). The adaptive immune response in celiac disease. Springer Seminars in Immunopathology.  ISSN 0344-4325.  34(4), s 523- 540 . doi: 10.1007/s00281-012-0314-z
• Sollid, Ludvig Magne; Qiao, Shuo Wang; Anderson, Robert P; Gianfrani, Carmen & Koning, Frits (2012). Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules. Immunogenetics.  ISSN 0093-7711.  64(6), s 455- 460 . doi: 10.1007/s00251-012-0599-z
• Baker, Kristi; Qiao, Shuo Wang; Kuo, Timothy T.; Aveson, Victoria G.; Platzer, Barbara; Andersen, Jan Terje; Sandlie, Inger; Chen, Zhangguo; de Haar, Colin; Lencer, Wayne I.; Fiebiger, Edda & Blumberg, Richard S. (2011). Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8(-)CD11b(+) dendritic cells. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(24), s 9927- 9932 . doi: 10.1073/pnas.1019037108
• Qiao, Shuo Wang; Raki, Melinda; Gunnarsen, Kristin Støen; Løset, Geir Åge; Lundin, Knut E A; Sandlie, Inger & Sollid, Ludvig Magne (2011). Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease. Journal of Immunology.  ISSN 0022-1767.  187(6), s 3064- 3071 . doi: 10.4049/jimmunol.1101526
• Rauhavirta, T.; Qiao, Shuo Wang; Jiang, Z.; Myrsky, E.; Loponen, J.; Korponay-Szabo, I.R.; Salovaara, H.; Garcia-Horsman, J.A.; Venäläinen, J.; Männistö, P.T.; Collighan, R.; Mongeot, A.; Griffin, M.; Mäki, M; Kaukinen, K & Lindfors, K. (2011). Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A. Clinical and Experimental Immunology.  ISSN 0009-9104.  164(1), s 127- 136 . doi: 10.1111/j.1365-2249.2010.04317.x
• Dørum, Siri; Arntzen, Magnus; Qiao, Shuo Wang; Holm, Anders; Koehler, Christian; Thiede, Bernd; Sollid, Ludvig Magne & Fleckenstein, Burkhard (2010). The Preferred Substrates for Transglutaminase 2 in a Complex Wheat Gluten Digest Are Peptide Fragments Harboring Celiac Disease T-Cell Epitopes. PLOS ONE.  ISSN 1932-6203.  5(11) . doi: 10.1371/journal.pone.0014056 Vis sammendrag

  Conclusion: TG2 as well as gastrointestinal proteolysis play important roles in the selection of gluten T-cell epitopes in celiac disease.

• Kuo, T; Baker, K; Yoshida, M; Qiao, Shuo Wang; Aveson, VG; Lencer, WI & Blumberg, RS (2010). Neonatal Fc Receptor: From Immunity to Therapeutics. Journal of Clinical Immunology.  ISSN 0271-9142.  30(6), s 777- 789 . doi: 10.1007/s10875-010-9468-4
• Baker, K; Qiao, Shuo Wang; Kuo, T; Kobayashi, K; Yoshida, M; Lencer, WI & Blumberg, RS (2009). Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. Springer Seminars in Immunopathology.  ISSN 0344-4325.  31(2), s 223- 236 . doi: 10.1007/s00281-009-0160-9
• Dørum, Siri; Qiao, Shuo Wang; Sollid, Ludvig Magne & Fleckenstein, Burkhard (2009). A Quantitative Analysis of Transglutaminase 2-Mediated Deamidation of Gluten Peptides: Implications for the T-cell Response in Celiac Disease. Journal of Proteome Research.  ISSN 1535-3893.  8(4), s 1748- 1755 . doi: 10.1021/pr800960n
• Kobayashi, Kanna; Qiao, Shuo Wang; Yoshida, Masaru; Baker, Kristi; Lencer, Wayne I. & Blumberg, Richard S. (2009). An FcRn-Dependent Role for Anti-flagellin Immunoglobulin G in Pathogenesis of Colitis in Mice. Gastroenterology.  ISSN 0016-5085.  137(5), s 1746- 1756 . doi: 10.1053/j.gastro.2009.07.059
• Qiao, Shuo Wang; Sollid, Ludvig Magne & Blumberg, Richard S (2009). Antigen presentation in celiac disease. Current Opinion in Immunology.  ISSN 0952-7915.  21(1), s 111- 117 . doi: 10.1016/j.coi.2009.03.004
• Stenman, SM; Venalainen, JI; Lindfors, K.; Auriola, S; Mauriala, T; Kaukovirta-Norja, A; Jantunen, A; Laurila, K; Qiao, Shuo Wang; Sollid, Ludvig Magne; Mannisto, Pekka T; Kaukinen, K & Mäki, M (2009). Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease. Annals of Medicine.  ISSN 0785-3890.  41(5), s 390- 400 . doi: 10.1080/07853890902878138
• Qiao, Shuo Wang; Kobayashi, K; Johansen, Finn Eirik; Sollid, Ludvig Magne; Andersen, Jan Terje; Milford, E; Roopenian, DC; Lencer, WI & Blumberg, RS (2008). Dependence of antibody-mediated presentation of antigen on FcRn. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  105, s 9337- 9342 . doi: 10.1073/pnas.0801717105
• Qiao, Shuo-Wang; Bergseng, Elin; Molberg, Øyvind; Jung, G; Fleckenstein, Burkhard & Sollid, Ludvig Magne (2005). Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: Importance of proline spacing and glutamine deamidation. Journal of Immunology.  ISSN 0022-1767.  175(1), s 254- 261
• Qiao, Shuo-Wang; Piper, J; Haraldsen, Guttorm; Øynebråten, Inger; Fleckenstein, Burkhard; Molberg, Øyvind; Khosla, C & Sollid, Ludvig Magne (2005). Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease. Journal of Immunology.  ISSN 0022-1767.  174, s 1657- 1663
• Shan, L; Qiao, Shuo Wang; Arentz-Hansen, Eva Helene; Molberg, Øyvind; Gray, G.M.; Sollid, Ludvig Magne & Khosla, C. (2005). Identification and Analysis of Multivalent Proteolytically Resistant Peptides from Gluten: Implications for Celiac Sprue. Journal of Proteome Research.  ISSN 1535-3893.  4, s 1732- 1741
• Fleckenstein, Burkhard; Qiao, Shuo-Wang; Larsen, MR; Jung, G; Roepstorff, P. & Sollid, Ludvig Magne (2004). Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides. Journal of Biological Chemistry.  ISSN 0021-9258.  279, s 17607- 17616
• Qiao, Shuo-Wang; Bergseng, Elin; Molberg, Øyvind; Xia, J; Fleckenstein, Burkhard; Khosla, C & Sollid, Ludvig Magne (2004). Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. Journal of Immunology.  ISSN 0022-1767.  173(3), s 1757- 1762
• Fleckenstein, Burkhard; Molberg, Øyvind; Qiao, Shuo Wang; Schmid, Dietmar G.; Mülbe, Florian von der; Elgstoen, Katja Benedikte Prestø; Jung, Günter & Sollid, Ludvig Magne (2002). Gliadin T Cell Epitope Selection by Tissue Transglutaminase in Celiac Disease. Role of Enzyme Specificity and pH Influence on the Transamidation Versus Deamidation Reactions. Journal of Biological Chemistry.  ISSN 0021-9258.  277, s 34109- 34116
• Boix, Fernando; Qiao, Shuo Wang; Kolpus, Tone & Sagvolden, Terje (1998). Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder. Behavioural Brain Research.  ISSN 0166-4328.  94(1), s 153- 162 Vis sammendrag

  Effects of chronic l-deprenyl administration on hyperactive behaviour and brain monoamine levels were studied in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto (WKY) rats. SHR were hyperactive, impulsive and had impaired sustained attention when tested with a multiple 2-min fixed interval 5-min extinction schedule of reinforcement. Even low, 0.25 mg/kg, doses of chronically-administered l-deprenyl reduced the impulsiveness ('bursts' of responses with short interresponse times) of SHR, without altering the general hyperactivity or the impaired sustained attention. The drug had no effect on WKY behaviour. The levels of noradrenaline, dopamine, serotonin and their metabolites, measured in neostriatum, nucleus accumbens, and frontal cortex, showed that l-deprenyl effectively inhibited monoamine oxidase (MAO) activity. These results suggest that impulsiveness is a behavioural component that may be operating independent of the other components, like hyperactivity and deficient sustained attention, and that can be reduced by chronic MAO-B inhibition with l-deprenyl in this strain of rats. The positive effect of l-deprenyl on impulsiveness is discussed as due either to normalization of an asymmetric dopaminergic activity in the nucleus accumbens, or to a restoration of normal dopamine function in the prefrontal cortex.

Se alle arbeider i Cristin

• Lindstad, Christian Borgen; Qiao, Shuo Wang; Johansen, Marie Kongshaug; Fugger, Lars; Sollid, Ludvig Magne & du Pré, Marie Fleur (2020). Characterization of T‐cell receptor transgenic mice recognizing immunodominant HLA‐DQ2.5‐restricted gluten epitopes. European Journal of Immunology.  ISSN 0014-2980.  00(0), s 1- 4 . doi: 10.1002/eji.202048859
• Lindeman, Ida; Emerton, Guy; Mamanova, Lira; Snir, Omri; Polanski, Krzysztof; Qiao, Shuo Wang; Sollid, Ludvig Magne; Teichmann, Sarah A & Stubbington, Michael J. T. (2018). BraCeR: B-cell-receptor reconstruction and clonality inference from single-cell RNA-seq. Nature Methods.  ISSN 1548-7091.  15(8), s 563- 565 . doi: 10.1038/s41592-018-0082-3 Fulltekst i vitenarkiv.
• Hou, Tieying; Qiao, Shuo Wang; Jin, Xi; Sidney, John; Sollid, Ludvig Magne; Macmillan, Henriette; Strohman, Michael; Yoon, Taejin & Mellins, Elizabeth (2012). Interaction of HLA-DM and HLA-DQ2 in antigen presentation: Implications for celiac disease association. Molecular Immunology.  ISSN 0161-5890.  51(1), s 40- 40 . doi: 10.1016/j.molimm.2012.03.005
• Hou, Tieying; Qiao, Shuo Wang; Jin, Xi; Sidney, John; Sollid, Ludvig Magne; Macmillan, Henriette; Strohman, Michael; Yoon, Taejin & Mellins, Elizabeth (2012). Interaction of HLA-DM and HLA-DQ2 in antigen presentation: Implications for celiac disease association. Molecular Immunology.  ISSN 0161-5890.  51(1), s 38- 38 . doi: 10.1016/j.molimm.2012.02.115
• Hou, Tieying; Qiao, Shuo Wang; Jin, Xi; Sidney, John; Sollid, Ludvig Magne & Mellins, Elizabeth (2012). Cryptic Fate of Gliadin Epitopes: Implication for Celiac Disease. Journal of Immunology.  ISSN 0022-1767.  188
• Høydahl, Lene Støkken; Neumann, Ralf Stefan; Qiao, Shuo Wang; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2011). Development of a High Affinity TCR Reagent by Phage Display to Study Antigen Presentation in Celiac Disease. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 372- 372
• Qiao, Shuo Wang; Raki, Melinda; Gunnarsen, Kristin Støen; Løset, Geir Åge; Sandlie, Inger & Sollid, Ludvig Magne (2011). Post-Translational Modification of Gluten Shapes the T Cell Response in Coeliac Disease by Direct Interaction with the T Cell Receptor. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 356- 356
• Qiao, Shuo Wang; Raki, Melinda; Løset, Geir Åge; Sandlie, Inger & Sollid, Ludvig Magne (2010). TCR Vbeta Bias and Semi-Public T Cell Responses In DQ2-Gliadin-Alpha-II Specific T Cells From Coeliac Disease Patients. Scandinavian Journal of Immunology.  ISSN 0300-9475.  71(6), s 511- +

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