Tom Eirik Mollnes

Bilde av Tom Eirik Mollnes
English version of this page
Mobiltelefon +47 90630015
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postadresse Postboks 4950 Nydalen OUS HF Rikshospitalet 0424 Oslo

Publikasjoner

  • Harboe M, Johnson C, Nymo S, Ekholt K, Schjalm C, Lindstad JK, Pharo A, Hellerud BC, Ekdahl KN, Mollnes TE, Nilsson PH. (2017) Properdin binding to complement activating surfaces depends on initial C3b-deposition. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1612385114
  • Barratt-Due A, Pischke SE, Nilsson PH, Espevik T, Mollnes TE. (2017) Dual inhibition of complement and toll-like receptors as a novel approach to treat inflammatory diseases – C3 or C5 emerge together with CD14 as promising targets. J Leukocyte Biol 101:193-204.
  • Nymo S, Gustavsen A, Nilsson PH, Lau C, Espevik T, Mollnes TE. (2016) Human endothelial cell activation by Escherichia coli and Staphylococcus aureus is mediated by TNF and IL-1β secondarily to activation of C5 and CD14 in whole blood. J Immunol 196:2293-2299.
  • Meroni PL, Macor P, Durigutto P, De Maso L, Gerosa M, Ferraresso M, Borghi M, Mollnes TE, Tedesco F. (2016) Complement activation in anti-phospholipid syndrome and its inhibition to prevent re-thrombosis after arterial surgery. Blood 127:365-367.
  • Gustavsen A, Nymo S, Landsem A, Christiansen D, Ryan L, Husebye H, Lau C, Pischke SE, Lambris JD, Espevik T, Mollnes TE. (2016) Combined inhibition of complement and CD14 attenuates bacteria-induced inflammation in human whole blood more efficiently than antagonizing TLR4-MD2. J Infect Dis 214:140-150.
  • Skjeflo EW, Sagatun C, Dybwik K, Aam S, Urving SH, Nunn MA, Fure H, Lau C, Brekke OL, Huber-Lang M, Espevik T, Barratt-Due A, Nielsen EW, Mollnes TE. (2015) Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis. Crit Care 19:415:1-8.
  • Huber-Lang M, Barratt-Due A, Pischke SE, Sandanger Ø, Nilsson PH, Nunn MA, Denk S, Gaus W, Espevik T, Mollnes TE.(2014) Double-blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice. J Immunol 192:5324-5331.
  • Rokstad AM, Brekke OL, Steinkjer B, Ryan L, Kolláriková G, Strand BL, Skjåk-Bræk G, Lacík I, Espevik T, Mollnes TE. (2011) Alginate microbeads are complement-compatible in contrast to polycation containing microcapsules revealed by a human whole blood model. Acta Biomater 7:25678.
  • Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE. (2011) Ornithodoros moubata complement inhibitor (OmCI) is an equally effective C5 inhibitor in pig and human. J Immunol 187:4913-4919.
  • Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tønnessen TI, Johansen HT, Castellheim A, Mollnes TE. (2010) CD14-inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli-sepsis in pigs. FASEB J 24:712-722.
  • Husebye H, Hjelmseth M, Stenvik J, Samstad E, Skjeldal F, Halaas Ø, Nilsen, NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T. (2010) The Rab11a GTPase selectively controls Toll-like receptor 4 induced IRF3 activation by regulating trafficking to phagosomes. Immunity 33:583-596.
  • Lappegård KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J, Nielsen EW, Bergseth G, Fadnes D, Abrahamsen TG, Høiby EA, Schejbel L, Garred P, Lambris JD, Harboe M, Mollnes TE. (2009) Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proc Natl Acad Sci USA 106:15861-15866.
  • Fiane AE, Ueland T, Simonsen S, Scott H, Endresen K, Gullestad L, Geiran OR, Haraldsen G, Heggelund L, Andreassen AK, Wergeland R, Frøland SS, Aukrust P, Mollnes, T.E. (2005) Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischemia and rejection after human heart transplantation. Eur Heart J 26:1660-1665.
  • Fiane AE, Ueland T, Simonsen S, Scott H, Endresen K, Gullestad L, Geiran OR, Haraldsen G, Heggelund L, Andreassen AK, Wergeland R, Frøland SS, Aukrust P, Mollnes, T.E. (2005) Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischemia and rejection after human heart transplantation. Eur Heart J 26:1660-1665.
  • Trøseid M, Lappegård KT, Claudi T, Damås JK, Mørkrid L, Brendberg R, Mollnes TE. (2004) Excersice reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. Eur Heart J 25:350-356.
  • Sprong T, Brandtzaeg P, Fung M, Pharo A, Høiby AE, Michaelsen T, Aase A, van der Meer JWM, van Deuren M, Mollnes TE. (2003) Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis. Blood 102:3702-3710.
  • Fiane AE, Videm V, Lingaas PS, Heggelund L, Nielsen EW, Geiran OR, Fung M, Mollnes TE. (2003) Mechanism of complement activation and its role in the inflammatory response following thoraco-abdominal aortic aneurysm repair. Circulation 108:849-856.
  • Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegård KT, Köhl J, Lambris J. (2002) Essential role of the C5a receptor in E. coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 100:1869-1877.
  • Aukrust P, Gullestad L, Lappegård KT, Ueland T, Aass H, Wikeby L, Simonsen S, Frøland SS, Mollnes TE. (2001) Complement activation in patients with congestive heart failure - effect of high-dose intravenous immunoglobulin treatment. Circulation 104:1494-1500.
  • Brandtzaeg P, Høgåsen K, Kierulf P, Mollnes TE. (1996) The excessive complement activation in fulminant meningococcal septicemia is predominantly caused by alternative pathway activation. J Infect Dis 173:647-655.

Se alle arbeider i Cristin

  • van den Heuvel, Lambertus P.; van de Kar, Nicole C.A.J.; Duineveld, Caroline; Sarlea, Andrei; van der Velden, Thea J.A.M. & Liebrand, Wilhelmus T. B. [Vis alle 12 forfattere av denne artikkelen] (2020). The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment. Cellular & Molecular Immunology. ISSN 1672-7681. 17(6), s. 653–655. doi: 10.1038/s41423-020-0406-y.
  • Storjord, Elin; Hennø, Linda Torrissen; Mollnes, Tom Eirik & Brekke, Ole-Lars (2020). Analyse av cytokiner. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(1), s. 1–3. doi: 10.4045/tidsskr.18.0961.
  • Bjerkhaug, Aline; Granslo, Hildegunn Norbakken; Cavanagh, Jorunn Pauline; Ludviksen, Judith Anita; Mollnes, Tom Eirik & Klingenberg, Claus (2020). Combined inhibition of CD14 and C5 in Escherichia coli and Group B streptococci induced inflammation in human cord blood. .
  • Bjerkhaug, Aline; Granslo, Hildegunn Norbakken; Cavanagh, Jorunn Pauline; Mollnes, Tom Eirik & Klingenberg, Claus (2019). The method of combined inhibition of CD14 and C5 in Escherichia coli and Streptococcus agalactiae induced inflammation in human cord blood.
  • Storm, Benjamin; Christiansen, Dorte; Fure, Hilde; Nielsen, Erik Waage & Mollnes, Tom Eirik (2019). Air bubbles induce a complement-dependent cytokine release in human whole blood in vitro and venous air embolism leads to an inflammatory response in pigs in vivo. Molecular Immunology. ISSN 0161-5890. 114.
  • Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona & Jacobsen, Eva Astrid [Vis alle 12 forfattere av denne artikkelen] (2019). Cholesterol crystals induce thromboinflammation.
  • Ehrnstrøm, Birgitta; Kojen, June Frengen; Moen, Siv Helen; Damås, Jan Kristian; Mollnes, Tom Eirik & Hu, Zhenyi [Vis alle 9 forfattere av denne artikkelen] (2019). Toll-like receptor 8 senses bacteria in human whole blood.
  • Mollnes, Tom Eirik (2019). Complement C5 conformation is critical for thrombin-mediated cleavage revealed by a novel human whole blood model.
  • Sokolova, Marina; Ekholt, Karin; Mollnes, Tom Eirik & Pischke, Søren (2019). HYPOXIA FOLLOWED BY WHOLE BLOOD REOXYGENATIONINDUCED ENDOTHELIAL CELL ACTIVATION IN A COMPLEMENTC5 AND TOLL-LIKE RECEPTOR CD14 DEPENDENT MANNER.
  • Cedzyński, Maciej; Thielens, Nicole M.; Mollnes, Tom Eirik & Vorup-Jensen, Thomas (2019). Editorial: The Role of Complement in Health and Disease. Frontiers in Immunology. ISSN 1664-3224. 10(1869). doi: 10.3389/fimmu.2019.01869.
  • Ehrnström, Birgitta; Kojen, June Frengen; Moen, Siv Helen; Damås, Jan Kristian; Afset, Jan Egil & Mollnes, Tom Eirik [Vis alle 10 forfattere av denne artikkelen] (2018). Toll-like Receptor 8 is a Major Bacterial Sensor in Human Monocytes and Blood.
  • Rokstad, Anne Mari; Gravastrand, Caroline S.; Halvorsen, Bente; Steinkjer, Bjørg; Skjelland, Mona & Jacobsen, Eva Astrid [Vis alle 10 forfattere av denne artikkelen] (2018). Cholesterol crystals induce coagulation that can be prevented by targeting complement.
  • Skovdahl, Helene Kolstad; Bruland, Torunn; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet & Doseth, Berit [Vis alle 8 forfattere av denne artikkelen] (2018). P093 CCL20 and CCR6 on peripheral blood mononuclear cells (PBMC) in inflammatory bowel disease (IBD): a more potent chemokine in ulcerative colitis .
  • Nielsen, Erik Waage; Storm, Benjamin; Christiansen, Dorte & Mollnes, Tom Eirik (2018). Venous air embolism-indiced coagulation prevented by complement C5 inhibition. Molecular Immunology. ISSN 0161-5890. 102, s. 192–193.
  • Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bruland, Torunn & Doseth, Berit [Vis alle 8 forfattere av denne artikkelen] (2018). CCL20 and CCR6 in peripheral blood mononuclear cells (PBMCs) in Inflammatory Bowel Disease (IBD): A more potent chemokine in Ulcerative Colitis.
  • Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Bakke, Ingunn & Thorsvik, Silje [Vis alle 12 forfattere av denne artikkelen] (2018). Tu1753 - type 1 Interferon Signaling in Intestinal Epithelial Cells During Active Inflammatory Bowel Disease. Gastroenterology. ISSN 0016-5085. 154(6). doi: 10.1016/S0016-5085%2818%2933379-1.

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Publisert 13. apr. 2011 11:42 - Sist endret 29. jan. 2020 11:08

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