Trond Buanes

• Krogvold, Lars; Genoni, Angelo; Puggioni, Anna; Campani, Daniela; Richardson, Sarah J. & Flaxman, Christine S. [Vis alle 10 forfattere av denne artikkelen] (2022). Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study. Diabetologia. ISSN 0012-186X. 65, s. 2108–2120. doi: 10.1007/s00125-022-05779-2. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Aims/hypothesis Enterovirus (EV) infection of pancreatic islet cells is one possible factor contributing to type 1 diabetes development. We have reported the presence of EV genome by PCR and of EV proteins by immunohistochemistry in pancreatic sections. Here we explore multiple human virus species in the Diabetes Virus Detection (DiViD) study cases using innovative methods, including virus passage in cell cultures. Methods Six recent-onset type 1 diabetes patients (age 24–35) were included in the DiViD study. Minimal pancreatic tail resection was performed under sterile conditions. Eleven live cases (age 43–83) of pancreatic carcinoma without diabetes served as control cases. In the present study, we used EV detection methods that combine virus growth in cell culture, gene amplification and detection of virus-coded proteins by immunofluorescence. Pancreas homogenates in cell culture medium were incubated with EV-susceptible cell lines for 3 days. Two to three blind passages were performed. DNA and RNA were extracted from both pancreas tissue and cell cultures. Real-time PCR was used for detecting 20 different viral agents other than EVs (six herpesviruses, human polyomavirus [BK virus and JC virus], parvovirus B19, hepatitis B virus, hepatitis C virus, hepatitis A virus, mumps, rubella, influenza A/B, parainfluenza 1–4, respiratory syncytial virus, astrovirus, norovirus, rotavirus). EV genomes were detected by endpoint PCR using five primer pairs targeting the partially conserved 5′ untranslated region genome region of the A, B, C and D species. Amplicons were sequenced. The expression of EV capsid proteins was evaluated in cultured cells using a panel of EV antibodies. Results Samples from six of six individuals with type 1 diabetes (cases) and two of 11 individuals without diabetes (control cases) contained EV genomes ( p <0.05). In contrast, genomes of 20 human viruses other than EVs could be detected only once in an individual with diabetes (Epstein–Barr virus) and once in an individual without diabetes (parvovirus B19). EV detection was confirmed by immunofluorescence of cultured cells incubated with pancreatic extracts: viral antigens were expressed in the cytoplasm of approximately 1% of cells. Notably, infection could be transmitted from EV-positive cell cultures to uninfected cell cultures using supernatants filtered through 100 nm membranes, indicating that infectious agents of less than 100 nm were present in pancreases. Due to the slow progression of infection in EV-carrying cell cultures, cytopathic effects were not observed by standard microscopy but were recognised by measuring cell viability. Sequences of 5′ untranslated region amplicons were compatible with EVs of the B, A and C species. Compared with control cell cultures exposed to EV-negative pancreatic extracts, EV-carrying cell cultures produced significantly higher levels of IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP1). Conclusions/interpretation Sensitive assays confirm that the pancreases of all DiViD cases contain EVs but no other viruses. Analogous EV strains have been found in pancreases of two of 11 individuals without diabetes. The detected EV strains can be passaged in series from one cell culture to another in the form of poorly replicating live viruses encoding antigenic proteins recognised by multiple EV-specific antibodies. Thus, the early phase of type 1 diabetes is associated with a low-grade infection by EVs, but not by other viral agents. Graphical abstract

• Sahakyan, Mushegh A.; Verbeke, Caroline S.; Tholfsen, Tore; Ignjatovic, Dejan; Kleive, Dyre & Buanes, Trond [Vis alle 10 forfattere av denne artikkelen] (2021). Prognostic Impact of Resection Margin Status in Distal Pancreatectomy for Ductal Adenocarcinoma. Annals of Surgical Oncology. ISSN 1068-9265. 29, s. 366–375. doi: 10.1245/s10434-021-10464-6. Fulltekst i vitenarkiv Vis sammendrag

  Background. Resection margin status is considered one of the few surgeon-controlled parameters affecting prognosis in pancreatic ductal adenocarcinoma (PDAC). While studies mostly focus on resection margins in pancreatoduodenectomy, little is known about their role in distal pancreatectomy (DP). This study aimed to investigate resection margins in DP for PDAC.<p> <p>Methods. Patients who underwent DP for PDAC between October 2004 and February 2020 were included (n = 124). Resection margins and associated parameters were studied in two consecutive time periods during which different pathology examination protocols were used: non-standardized (period 1: 2004–2014) and standardized (period 2: 2015–2020). Microscopic margin involvement (R1) was defined as B1 mm clearance.<p> <p>Results. Laparoscopic and open resections were performed in 117 (94.4%) and 7 (5.6%) patients, respectively. The R1 rate for the entire cohort was 73.4%, increasing from 60.4% in period 1 to 83.1% in period 2 (p = 0.005). A significantly higher R1 rate was observed for the posterior margin (35.8 vs. 70.4%, p\0.001) and anterior pancreatic surface (based on a 0 mm clearance; 18.9 vs. 35.4%, p = 0.045). Pathology examination period, poorly differentiated PDAC, and vascular invasion were associated with R1 in the multivariable model. Extended DP, positive anterior pancreatic surface, lymph node ratio, perineural invasion, and adjuvant chemotherapy, but not R1, were significant prognostic factors for overall survival in the entire cohort.<p> <p>Conclusions. Pathology examination is a key determinant of resection margin status following DP for PDAC. A high R1 rate is to be expected when pathology examination is meticulous and standardized. Involvement of the anterior pancreatic surface affects prognosis.

• Oikarinen, Sami; Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Korsgren, Olle & Laiho, Jutta E. [Vis alle 13 forfattere av denne artikkelen] (2021). Characterisation of enterovirus RNA detected in the pancreas and other specimens of live patients with newly diagnosed type 1 diabetes in the DiViD study. Diabetologia. ISSN 0012-186X. 64, s. 2491–2501. doi: 10.1007/s00125-021-05525-0. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Aims/hypothesis The Diabetes Virus Detection (DiViD) study is the first study to laparoscopically collect pancreatic tissue and purified pancreatic islets together with duodenal mucosa, serum, peripheral blood mononuclear cells (PBMCs) and stools from six live adult patients (age 24–35 years) with newly diagnosed type 1 diabetes. The presence of enterovirus (EV) in the pancreatic islets of these patients has previously been reported. Methods In the present study we used reverse transcription quantitative real-time PCR (RT-qPCR) and sequencing to characterise EV genomes present in different tissues to understand the nature of infection in these individuals. Results All six patients were found to be EV-positive by RT-qPCR in at least one of the tested sample types. Four patients were EV-positive in purified islet culture medium, three in PBMCs, one in duodenal biopsy and two in stool, while serum was EV-negative in all individuals. Sequencing the 5′ untranslated region of these EVs suggested that all but one belonged to enterovirus B species. One patient was EV-positive in all these sample types except for serum. Sequence analysis revealed that the virus strain present in the isolated islets of this patient was different from the strain found in other sample types. None of the islet-resident viruses could be isolated using EV-permissive cell lines. Conclusions/interpretation EV RNA can be frequently detected in various tissues of patients with type 1 diabetes. At least in some patients, the EV strain in the pancreatic islets may represent a slowly replicating persisting virus. Graphical abstract

• Sahakyan, Mushegh; Røsok, Bård Ingvald; Tholfsen, Tore; Kleive, Dyre; Waage, Anne & Ignjatovic, Dejan [Vis alle 9 forfattere av denne artikkelen] (2021). Implementation and training with laparoscopic distal pancreatectomy: 23-year experience from a high-volume center. Surgical Endoscopy. ISSN 0930-2794. s. 1–12. doi: 10.1007/s00464-021-08306-3. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Background Distal pancreatectomy is the most common procedure in minimally-invasive pancreatic surgery. Data in the literature suggest that the learning curve flattens after performing up to 30 procedures. However, the exact number remains unclear. Methods The implementation and training with laparoscopic distal pancreatectomy (LDP) in a high-volume center were studied between 1997 and 2020. Perioperative outcomes and factors related to conversion were assessed. The individual experiences of four different surgeons (pioneer and adopters) performing LDP on a regular basis were examined. Results Six hundred forty LDPs were done accounting for 95% of all distal pancreatectomies performed throughout the study period. Conversion was needed in 14 (2.2%) patients due to intraoperative bleeding or tumor adherence to the major vasculature. Overall morbidity and mortality rates were 35 and 0.6%, respectively. Intra- and postoperative outcomes did not change for any of the surgeons within their first 40 cases. Operative time significantly decreased after the first 80 cases for the pioneer surgeon and did not change afterwards although the proportion of ductal adenocarcinoma increased. Tumor size increased after the first 80 cases for the first adopter without affecting the operative time. Conclusions In this nearly unselected cohort, no significant changes in surgical outcomes were observed throughout the first 40 LDPs for different surgeons. The exact number of procedures required to overcome the learning curve is difficult to determine as it seems to depend on patient selection policy and specifics of surgical training at the corresponding center.

• Sahakyan, Mushegh; Tholfsen, Tore; Kleive, Dyre; Waage, Anne; Buanes, Trond & Labori, Knut Jørgen [Vis alle 8 forfattere av denne artikkelen] (2020). Laparoscopic distal pancreatectomy in patients with poor physical status. HPB. ISSN 1365-182X. s. 1–5. doi: 10.1016/j.hpb.2020.10.004. Fulltekst i vitenarkiv
• Sahakyan, Mushegh; Tholfsen, Tore; Kleive, Dyre; Yaqub, Sheraz; Kazaryan, Airazat M. & Buanes, Trond [Vis alle 9 forfattere av denne artikkelen] (2020). Laparoscopic distal pancreatectomy following prior upper abdominal surgery (pancreatectomy and prior surgery). Journal of Gastrointestinal Surgery. ISSN 1091-255X. s. 1–8. doi: 10.1007/s11605-020-04858-2. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Background and Purpose Previous abdominal surgery can be a risk factor for perioperative complications in patients undergoing laparoscopic procedures. Today, distal pancreatectomy is increasingly performed laparoscopically. This study investigates the consequences of prior upper abdominal surgery (PUAS) for laparoscopic distal pancreatectomy (LDP). Methods Patients who had undergone LDP from April 1997 to January 2020 were included. Based on the history and type of PUAS, these were categorized into three groups: minimally invasive (I), open (II), and no PUAS (III). To reduce possible confounding factors, the groups were matched in 1:2:4 fashion based on age, sex, body mass index (BMI) and American Society of Anesthesiology grade. Results After matching, 30, 60, and 120 patients were included in the minimally invasive, open and no PUAS groups, respectively. No statistically significant differences were found in terms of intraoperative outcomes. Postoperative morbidity, mortality and length of hospital stay were similar. Open PUAS was associated with higher Comprehensive Complication Index (33.7 vs 20.9 vs 26.2, p  = 0.03) and greater proportion of patients with ≥ 2 complications (16.7 vs 0 vs 6.7%, p  = 0.02) compared with minimally invasive and no PUAS. Male sex, overweight (BMI 25–29.9 kg/m 2 ), diagnosis of neuroendocrine neoplasia, and open PUAS were risk factors for severe morbidity in the univariable analysis. Only open PUAS was statistically significant in the multivariable model. Conclusions PUAS does not impair the feasibility and safety of LDP as its perioperative outcomes are largely comparable to those in patients without PUAS. However, open PUAS increases the burden and severity of postoperative complications.

• Heiberg, Turid; Baekelandt, Bart Maria Gilbert; Kvien, Tore Kristian & Buanes, Trond (2019). Psychometric performance of the PAncreatic CAncer disease impact (PACADI) score. Pancreatology (Print). ISSN 1424-3903. 19(7). doi: 10.1016/j.pan.2019.09.001. Fulltekst i vitenarkiv Vis sammendrag

  Background/Objective Pancreatic Cancer Disease Impact (PACADI) score measures the impact of pancreatic cancer (PC) on important health dimensions, selected by patients. The aim of this single center study was to test the psychometric performance of the Pancreatic Cancer Disease Impact (PACADI) score. Methods Patients with suspected pancreatic cancer (PC) completed PACADI, the EuroQol-5D (EQ-5D index) and Edmonton Symptom Assessment System (ESAS) in this longitudinal observational study. Measures were compared across patients with PC (n = 210), other malignant lesions (OML) (n = 109) and non-malignant lesions (NML) (n = 41). Associations, test-retest and internal consistency reliability, longitudinal changes, sensitivity to change and prediction of mortality during the first year were examined in patients with PC. Results The three measures discriminated between PC and OML. The PACADI score correlated strongly at baseline (n = 199)/after three months (n = 85) with the EQ-5D index and ESAS “sense of well-being” (0.64 and 0.66/0.73 and 0.69, p < 0.001, respectively), showed high test-retest reliability (ICC 0.84) and very good internal consistency reliability (Cronbach's alpha 0.81–0.85) across all visits. Scores improved over time at 3, 6, 9 and 12 months for survivors, and standardized response mean (SRM) for improvement between 2 and 3 months (n = 44) was 0.80 (PACADI), −0.59 (EQ-5D index) and 0.69 (ESAS “sense of well-being”). The PACADI score significantly predicted mortality within the first year (p = 0.02) in contrast to the EQ-5D index and ESAS “sense of well-being”. Conclusion This study showed satisfactory psychometric performance of the PACADI score. The results support its use in clinical practice and intervention trials.

• Ånonsen, Kim Vidar; Sahakyan, Mushegh; Kleive, Dyre; Waage, Anne; Verbeke, Caroline Sophie & Hauge, Truls [Vis alle 9 forfattere av denne artikkelen] (2019). Trends in management and outcome of cystic pancreatic lesions - analysis of 322 cases undergoing surgical resection. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(8), s. 1051–1057. doi: 10.1080/00365521.2019.1642379. Fulltekst i vitenarkiv Vis sammendrag

  Background: Several guidelines for the management of cystic pancreatic lesions (CPL) exists. From 2013, Oslo University Hospital adapted the European consensus guidelines (ECG) in the decision-making as to whether patients should be advised to have resection or observation for CPL. The aims of the study were to assess changes over time in the workup and diagnostic accuracy of resected CPL, and the short-term surgical outcome. Methods: Preoperative radiological workup, clinicopathological characteristics, and perioperative outcomes were retrospectively reviewed in three consecutive time periods (early: 2004–2008, intermediate: 2009–2012, late: 2013–2016). The rate of concordance between the ECG recommendations for resection (ECG+) or observation (ECG–) and the final histological diagnosis were assessed. Results: A total of 322 consecutive patients underwent resection for CPL (early: n = 89, intermediate: n = 108, late: n = 125). The most common diagnoses were intraductal papillary mucinous neoplasia (IPMN, 36.0%), serous cystic neoplasm (SCN, 23.9%), mucinous cystic neoplasm (10.6%), pseudocyst (9.6%), solid pseudopapillary neoplasm (7.8%), and cystic pancreatic neuroendocrine tumour (5.3%). The proportion of ECG+ CPL undergoing surgery increased significantly (42.7% vs. 60.7% vs. 70.4%, p < .001). The relative proportion of patients undergoing resection for SCN decreased (38.2% vs. 21.3% vs. 16.0%), whereas it increased for IPMN (31.5% vs. 30.6% vs. 44.0%). The use of magnetic resonance imaging and endoscopic ultrasound increased. There were no differences in postoperative severe complications (23.0% vs. 23.6%) or 90-day mortality (2.3% vs. 0.8%) between ECG+ and ECG– patients. Conclusion: Several changes in the management of CPL were revealed during time. Adherence to guidelines is important in order to avoid unnecessary surgery for CPL.

• Sahakyan, Mushegh; Haugvik, Sven-Petter; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Ignjatovic, Dejan & Buanes, Trond [Vis alle 9 forfattere av denne artikkelen] (2018). Can standardized pathology examination increase the lymph node yield following laparoscopic distal pancreatectomy for ductal adenocarcinoma? HPB. ISSN 1365-182X. 20(2), s. 175–181. doi: 10.1016/j.hpb.2017.08.038. Fulltekst i vitenarkiv
• Baekelandt, Bart Maria Gilbert; Fagerland, Morten; Hjermstad, Marianne Jensen; Heiberg, Turid; Labori, Knut Jørgen & Buanes, Trond (2018). Survival, Complications and Patient Reported Outcomes after Pancreatic Surgery. HPB. ISSN 1365-182X. doi: 10.1016/j.hpb.2018.07.023. Fulltekst i vitenarkiv Vis sammendrag

  Background: Long-term effects of complications in pancreatic surgery have not been systematically evaluated. The objectives were to assess potential effects of complications on survival and patient reported outcomes (PROs) as well as feasibility of PRO questionnaires in patients with periampullary and pancreatic tumors. Methods: From October 2008 to December 2011, 208 patients undergoing pancreatic surgery were included in a prospective observational study. ESAS, EORTC QLQ-C30 and QLQ-PAN26 questionnaires were completed at inclusion, then every third month. Complications were recorded according to the Clavien-Dindo (CD) classification and Comprehensive Complication Index (CCI). Results: 148 complications were registered in 100 patients (48%), 36 patients (17%) had CD IIIa or above. 125 patients (60%) completed baseline questionnaires, 80 (39%) responded after three and 54 (28%) after six months. Complications were associated with reduced long-term survival in patients with pancreatic ductal adenocarcinoma (PDAC) (p = 0.049) and other malignant diseases. No significant relationship was found between complications and PROs, except for anxiety, which was significantly increased in patients with complications. Conclusion: Postoperative complications led to increased anxiety at 3 months after surgery and were associated with reduced long-term survival in patients with malignancy. A short, patient derived, disease specific questionnaire is required in the clinical research context.

• Buanes, Trond & Edwin, Bjørn (2018). Long term oncological outcome of laparoscopic techniques in pancreatic cancer. World Journal of Gastrointestinal Endoscopy (WJGE). 10(12), s. 383–391. doi: 10.4253/wjge.v10.i12.383. Fulltekst i vitenarkiv Vis sammendrag

  The laparoscopic technique in distal pancreatic resection (LDP) has been widely accepted, and outcome data support the hypothesis that survival is improved, partly due to improved postoperative safety and recovery, thus optimizing treatment with adjuvant chemotherapy. But laparoscopic pancreaticoduodenectomy (LPD or Whipple-procedures) has spread more slowly, due to the complexity of the procedure. Surgical safety has been a problem in hospitals with low patient volume, resulting in raised postoperative mortality, requiring careful monitoring of outcome during the surgical learning curve. Robotic assistance is expected to improve surgical safety, but data on long term oncological outcome of laparoscopic Whipple procedures with or without robotic assistance is scarce. Future research should still focus surgical safety, but most importantly long term outcome, recorded as recurrence at maximal follow up or - at best - overall long term survival (OS). Available data show median survival above 2.5 years, five year OS more than 30% after LDP even in series with suboptimal adjuvant chemotherapy. Also after LPD, long term survival is reported equal to or longer than open resection. However, surgical safety during the learning curve of LPD is a problem, which hopefully can be facilitated by robotic assistance. Patient reported outcome should also be an endpoint in future trials, including patients with pancreatic ductal adenocarcinoma.

• Sahakyan, Mushegh; Edwin, Bjørn; Kazaryan, Airazat M.; Barkhatov, Leonid; Buanes, Trond & Ignjatovic, Dejan [Vis alle 8 forfattere av denne artikkelen] (2017). Perioperative outcomes and survival in elderly patients undergoing laparoscopic distal pancreatectomy. Journal of Hepato-Biliary-Pancreatic Sciences. ISSN 1868-6974. 24(1), s. 42–48. doi: 10.1002/jhbp.409. Fulltekst i vitenarkiv
• Buanes, Trond (2017). Role of surgery in pancreatic cancer. World Journal of Gastroenterology (WJG). ISSN 1007-9327. 23(21), s. 3765–3770. doi: 10.3748/wjg.v23.i21.3765. Fulltekst i vitenarkiv
• Ånonsen, Kim Vidar; Fagerland, Morten; Edwin, Bjørn; Labori, Knut Jørgen; Kure, E.H. & Hauge, Truls [Vis alle 7 forfattere av denne artikkelen] (2017). Cyst fluid CEA concentration discriminates between benign and premalignant/malignant pancreatic cystic lesions. A prospective cohort study. Short title: Diagnostic yield of pancreatic cyst fluid CEA analysis. EC Gastroenterology and Digestive System. ISSN 2276-1209. 02, s. 426–436. Fulltekst i vitenarkiv Vis sammendrag

  Background: The objective was to evaluate cyst fluid carcinoembryonic antigen (CEA) as a putative marker of malignant potential in cystic pancreatic lesions (CPLs). Methods: Prospective observational cohort study from October 2008 to September 2013. A total of 190 patients with CPL were in- cluded after signed informed consent. Endoscopic ultrasound and fine needle aspiration (EUS-FNA) of cyst fluid for analysis of CEA was performed as part of the multimodal preoperative workup. The diagnostic performance of cyst fluid CEA value for the selection of the right patients for surgery was evaluated by histological diagnosis as endpoint in operated patients. Diagnostic accuracy of cyst fluid CEA was assessed by receiver operating characteristics (ROC) analysis. Results: Surgical resection was performed in 65 patients (34.2%) after evaluation by the multidisciplinary team (MDT). Lesions with malignant potential or invasive carcinomas were found in 46 (70.8%) of resected cases. Area under the ROC curve (AUC) for cyst fluid CEA was 0.71 (95% CI 0.61 - 0.81). The optimal cut-off value was 36.3 ng/mL (sensitivity 74%, specificity 62%, PPV 51%, NPV 81%, accuracy 66%). A total of 125 patients (65.8%) were never operated, 15 because of unresectable carcinoma. None of the 110 patients undergoing conservative management developed malignancy at a median follow-up of 46.5 months (range 4 - 86 months). Conclusion: There is a significant diagnostic yield of cyst fluid CEA determination, when the indication for surgical exploration is focused.

• Hauge, Truls; Ånonsen, Kim Vidar & Buanes, Trond (2017). Management of Pancreatic Cysts (PC)- Based on Cumulative Knowledge. EC Gastroenterology and Digestive System. ISSN 2276-1209. 02, s. 437–439. Fulltekst i vitenarkiv Vis sammendrag

  The different risk of malignancy in various cystic pancreatic neoplasms has been well known for more than two decades, and thera- peutic management has been improved accordingly. Numerous guidelines have directed the progress, based on the technological development in health care within imaging, endoscopy and surgery. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and minimally invasive/laparoscopic techniques are relevant examples. [...]

• Kuric, Enida; Seiron, Peter; Krogvold, Lars; Edwin, Bjørn; Buanes, Trond & Hanssen, Kristian Folkvord [Vis alle 9 forfattere av denne artikkelen] (2017). Demonstration of tissue resident memory CD8 T cells in insulitic lesions in adult patients with recent-onset type 1 diabetes. American Journal of Pathology. ISSN 0002-9440. 187(3), s. 581–588. doi: 10.1016/j.ajpath.2016.11.002. Fulltekst i vitenarkiv
• Sahakyan, Mushegh; Kim, Song Cheol; Kleive, Dyre; Kazaryan, Airazat M.; Song, Ki Byung & Ignjatovic, Dejan [Vis alle 10 forfattere av denne artikkelen] (2017). Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: Long-term oncologic outcomes after standard resection. Surgery. ISSN 0039-6060. 162(4), s. 802–811. doi: 10.1016/j.surg.2017.06.009. Fulltekst i vitenarkiv
• Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Skrede, Martina; Hamfjord, Julian & Larsen, Astrid Marie [Vis alle 14 forfattere av denne artikkelen] (2016). Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma. Molecular Oncology. ISSN 1574-7891. 10(2), s. 303–316. doi: 10.1016/j.molonc.2015.10.011. Fulltekst i vitenarkiv
• Sandhu, Vandana; Wedge, David C.; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Dentro, Stefan C. & Buanes, Trond [Vis alle 16 forfattere av denne artikkelen] (2016). The genomic landscape of pancreatic and periampullary adenocarcinoma. Cancer Research. ISSN 0008-5472. 76(17), s. 5092–5102. doi: 10.1158/0008-5472.CAN-16-0658. Fulltekst i vitenarkiv
• Buanes, Trond (2016). Updated therapeutic outcome for patients with periampullary and pancreatic cancer related to recent translational research. World Journal of Gastroenterology (WJG). ISSN 1007-9327. 22(48), s. 10502–10511. doi: 10.3748/wjg.v22.i48.10502. Fulltekst i vitenarkiv
• Labori, Knut Jørgen; H, Katz Matthew; Tzeng, Ching; Bjørnbeth, Bjørn Atle; Småstuen, Milada Cvancarova & Edwin, Bjørn [Vis alle 11 forfattere av denne artikkelen] (2016). Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study. Acta Oncologica. ISSN 0284-186X. 55(3), s. 265–277. doi: 10.3109/0284186X.2015.1068445. Fulltekst i vitenarkiv
• Baekelandt, Bart Maria Gilbert; Hjermstad, Marianne Jensen; Nordby, Tom; Fagerland, Morten; Kure, Elin H. & Heiberg, Turid [Vis alle 8 forfattere av denne artikkelen] (2016). Preoperative cognitive function predicts survival in patients with resectable pancreatic ductal adenocarcinoma. HPB. ISSN 1365-182X. 18(3), s. 247–254. doi: 10.1016/j.hpb.2015.09.004. Fulltekst i vitenarkiv
• Hauge, Truls; Hauge, Petra Weber; Warloe, Trond; Drolsum, Anders; Johansen, Cathrine & Viktil, Ellen [Vis alle 9 forfattere av denne artikkelen] (2016). Randomised controlled trial of temoporfin photodynamic therapy plus chemotherapy in nonresectable biliary carcinoma-PCS Nordic study. Photodiagnosis and Photodynamic Therapy. ISSN 1572-1000. 13, s. 330–333. doi: 10.1016/j.pdpdt.2015.09.004. Fulltekst i vitenarkiv
• Hamfjord, Julian; Saldova, Radka; Stockmann, Henning; Sandhu, Vandana; Lothe, Inger Marie Bowitz & Buanes, Trond [Vis alle 10 forfattere av denne artikkelen] (2015). Serum N-glycome characterization in patients with resectable periampullary adenocarcinoma. Journal of Proteome Research. ISSN 1535-3893. 14(12), s. 5144–5156. doi: 10.1021/acs.jproteome.5b00395. Fulltekst i vitenarkiv
• Ånonsen, Kim Vidar; Buanes, Trond; Røsok, Bård Ingvald; Hauge, Truls & Edwin, Bjørn (2015). Outcome of laparoscopic surgery in patients with cystic lesions in the distal pancreas. JOP. Journal of the Pancreas. 16(3), s. 266–270. doi: 10.6092/1590-8577/2993. Fulltekst i vitenarkiv Vis sammendrag

  Context Recent guidelines for the management of cystic lesions of the pancreas recommend observation for selected neoplasms using imaging criteria. However, current imaging modalities lack diagnostic accuracy, and the indication for surgery is debated. Objective In this study we have explored the outcome of laparoscopic distal pancreatic resections in all patients referred with potential pancreatic cystic neoplasms, with histological diagnosis as endpoint. Methods Between 1997 and 2009 all patients referred to our tertiary referral centre having a cystic neoplasm of the distal pancreas accepted for surgery were included in the present observational study. Results A total of 69 patients were included. Sixty-two patients underwent distal pancreatectomies, in whom 19 were spleen-preserving, and 7 enucleations were performed. Two procedures were converted to open technique. The lesions removed in 27 patients (39%) were either malignant or premalignant. The final diagnoses were serous cystic neoplasm (n=29), mucinous cystic neoplasm (n=12), pseudocyst (n=11), solid pseudopapillary neoplasm (n=10), intraductal papillary mucinous neoplasm (n=5) and other (n=2). Overall morbidity was 33%; 56% of the complications were classified as mild. Fistula rate was 10%. One patient died postoperatively from a cerebral haemorrhage. Conclusion Most complications after laparoscopic distal resection of cystic pancreatic lesions are mild, but the proportion of patients with benign lesions (61%) has to be reduced by focused preoperative investigations. Endoscopic ultrasound examination (EUS), enabling aspiration of cyst fluid and fine needle aspiration is an additional option for the preoperative workup.

• Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Lingjærde, Ole Christian; Buanes, Trond & Dalsgaard, Astrid Marie [Vis alle 13 forfattere av denne artikkelen] (2015). Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas. Molecular Oncology. ISSN 1574-7891. 9(4), s. 758–771. doi: 10.1016/j.molonc.2014.12.002. Fulltekst i vitenarkiv
• Krogvold, Lars; Skog, Oskar; Sundström, Görel; Edwin, Bjørn; Buanes, Trond & Hanssen, Kristian Folkvord [Vis alle 10 forfattere av denne artikkelen] (2015). Function of isolated pancreatic islets from patients at onset of type 1 diabetes: Insulin secretion can be restored after some days in a nondiabetogenic environment in vitro results from the divid study. Diabetes. ISSN 0012-1797. 64(7), s. 2506–2512. doi: 10.2337/db14-1911. Fulltekst i vitenarkiv
• Krogvold, Lars; Wiberg, Anna; Edwin, Bjørn; Buanes, Trond; Jahnsen, Frode Lars & Hanssen, Kristian Folkvord [Vis alle 10 forfattere av denne artikkelen] (2015). Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes. Diabetologia. ISSN 0012-186X. 59(3), s. 492–501. doi: 10.1007/s00125-015-3820-4. Fulltekst i vitenarkiv Vis sammendrag

  Aims/hypothesis It is thought that T cells play a major role in the immune-mediated destruction of beta cells in type 1 diabetes, causing inflammation of the islets of Langerhans (insulitis). The significance of insulitis at the onset of type 1 diabetes is debated, and the role of the T cells poorly understood. Methods In the Diabetes Virus Detection (DiViD) study, pancreatic tissue from six living patients with recent-onset type 1 diabetes was collected. The insulitis was characterised quantitatively by counting CD3+ T cells, and qualitatively by transcriptome analysis targeting 84 T and B lymphocyte genes of laser-captured microdissected islets. The findings were compared with gene expression in T cells collected from kidney biopsies from allografts with ongoing cellular rejection. Cytokine and chemokine release from isolated islets was characterised and compared with that from islets from nondiabetic organ donors. Results All six patients fulfilled the criteria for insulitis (5–58% of the insulin-containing islets in the six patients had ≥15 T cells/islet). Of all the islets, 36% contained insulin, with several resembling completely normal islets. The majority (61– 83%) of T cells were found as peri-insulitis rather than within the islet parenchyma. The expression pattern of T cell genes was found to be markedly different in islets compared with the rejected kidneys. The islet-infiltrating T cells showed only background levels of cytokine/chemokine release in vitro. Conclusions/interpretation Insulitis and a significant reserve reservoir for insulin production were present in all six cases of recent-onset type 1 diabetes. Furthermore, the expression patterns and levels of cytokines argue for a different role of the T cells in type 1 diabetes when compared with allograft rejection.

• Sahakyan, Mushegh; Kazaryan, Airazat M.; Rawashdeh, Majd; Fuks, David; Shmavonyan, Mark & Haugvik, Sven-Petter [Vis alle 14 forfattere av denne artikkelen] (2015). Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: results of a multicenter cohort study on 196 patients. Surgical Endoscopy. ISSN 0930-2794. s. 1–10. doi: 10.1007/s00464-015-4623-x. Fulltekst i vitenarkiv
• Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Frisk, Gun; Skog, Oskar & Anagandula, Mahesh [Vis alle 19 forfattere av denne artikkelen] (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes. ISSN 0012-1797. 64(5), s. 1682–1687. doi: 10.2337/db14-1370. Fulltekst i vitenarkiv Vis sammendrag

  The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3-9 weeks after onset of type 1 diabetes in six adult patients (age 24-35 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunohistochemistry. Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh-frozen whole pancreatic tissue using PCR and sequencing. Nondiabetic organ donors served as controls. VP1 was detected in the islets of all type 1 diabetic patients (two of nine controls). Hyperexpression of class I HLA molecules was found in the islets of all patients (one of nine controls). Enterovirus-specific RNA sequences were detected in four of six patients (zero of six controls). The results were confirmed in various laboratories. Only 1.7% of the islets contained VP1(+) cells, and the amount of enterovirus RNA was low. The results provide evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, which is consistent with the possibility that a low-grade enteroviral infection in the pancreatic islets contributes to disease progression in humans.

• Buanes, Trond (2014). Pancreatic cancer-improved care achievable. World Journal of Gastroenterology (WJG). ISSN 1007-9327. 20(30), s. 10405–10418. doi: 10.3748/wjg.v20.i30.10405. Fulltekst i vitenarkiv
• Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Ludvigsson, Johnny; Korsgren, Olle & Hyöty, Heikki [Vis alle 9 forfattere av denne artikkelen] (2014). Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study. Diabetologia. ISSN 0012-186X. 57(4), s. 841–843. doi: 10.1007/s00125-013-3155-y. Fulltekst i vitenarkiv
• Skog, Oskar; Korsgren, Stella; Wiberg, Anna; Danielsson, Angelika; Edwin, Bjørn & Buanes, Trond [Vis alle 9 forfattere av denne artikkelen] (2014). Expression of human leukocyte antigen class i in endocrine and exocrine pancreatic tissue at onset of type 1 diabetes. American Journal of Pathology. ISSN 0002-9440. 185(1), s. 129–138. doi: 10.1016/j.ajpath.2014.09.004. Fulltekst i vitenarkiv
• Nordby, Tom; Hugenschmidt, Harald; Fagerland, Morten; Ikdahl, Tone; Buanes, Trond & Labori, Knut Jørgen (2013). Follow-up after curative surgery for pancreatic ductal adenocarcinoma: Asymptomatic recurrence is associated with improved survival. European Journal of Surgical Oncology. ISSN 0748-7983. 39(6), s. 559–566. doi: 10.1016/j.ejso.2013.02.020. Fulltekst i vitenarkiv
• Nordby, Tom; Ikdahl, Tone; Lothe, Inger Marie Bowitz; Fagerland, Morten; Heiberg, Turid & Hauge, Truls [Vis alle 8 forfattere av denne artikkelen] (2013). Improved survival and quality of life in patients undergoing R1 pancreatic resection compared to patients with locally advanced unresectable pancreatic adenocarcinoma. Pancreatology (Print). ISSN 1424-3903. 13(2), s. 180–185. doi: 10.1016/j.pan.2013.01.003. Fulltekst i vitenarkiv
• Heiberg, Turid; Nordby, Tom; Kvien, Tore Kristian & Buanes, Trond (2013). Development and preliminary validation of the pancreatic cancer disease impact score. Supportive Care in Cancer. ISSN 0941-4355. 21(6), s. 1677–1684. doi: 10.1007/s00520-012-1713-3. Fulltekst i vitenarkiv
• Nordby, Tom; Andersen, Tone Ikdahl; Lothe, Inger Marie Bowitz; Ånonsen, Kim Vidar; Hauge, Truls & Edwin, Bjørn [Vis alle 9 forfattere av denne artikkelen] (2013). Opportunities of improvement in the management of pancreatic and periampullary tumors: Prospective evaluation of outcome from a multidisciplinary research program. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 48(5), s. 617–625. doi: 10.3109/00365521.2013.781218. Fulltekst i vitenarkiv
• Monrad-Hansen, Jens Wiel; Buanes, Trond; Young, Victoria Solveig; Langebrekke, Anton & Qvigstad, Erik (2012). Endometriosis of the Pancreas. Journal of minimally invasive gynecology. ISSN 1553-4650. 19(4), s. 521–523. doi: 10.1016/j.jmig.2012.03.011. Fulltekst i vitenarkiv
• Marangos, Irina Pavlik; Buanes, Trond; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Rosseland, Arne Retvedt & Grzyb, Krzysztof [Vis alle 10 forfattere av denne artikkelen] (2012). Laparoscopic resection of exocrine carcinoma in central and distal pancreas results in a high rate of radical resections and long postoperative survival. Surgery. ISSN 0039-6060. 151(5), s. 717–723. doi: 10.1016/j.surg.2011.12.016. Fulltekst i vitenarkiv
• Haugen, Fred; Labori, Knut Jørgen; Noreng, Hans Jørgen; Buanes, Trond; Iversen, Per Ole & Drevon, Christian A (2011). Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer. Archives of Physiology and Biochemistry. ISSN 1381-3455. 117(2), s. 78–87. doi: 10.3109/13813455.2011.560609. Fulltekst i vitenarkiv
• Weden, Synne L. S.; Klemp, Marianne; Gladhaug, Ivar Prydz; Møller, Mona; Eriksen, Jon Amund & Gaudernack, Gustav [Vis alle 7 forfattere av denne artikkelen] (2011). Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras. International Journal of Cancer. ISSN 0020-7136. 128(5), s. 1120–1128. doi: 10.1002/ijc.25449. Fulltekst i vitenarkiv
• Røsok, Bård Ingvald; Marangos, Irina Pavlik; Kazaryan, Ayrazat; Rosseland, Arne Retvedt; Buanes, Trond & Mathisen, Øystein [Vis alle 7 forfattere av denne artikkelen] (2010). Single-centre experience of laparoscopic pancreatic surgery. British Journal of Surgery. ISSN 0007-1323. 97(6), s. 902–909. doi: 10.1002/bjs.7020. Fulltekst i vitenarkiv
• Buanes, Trond (2009). Endoscopic sealing of pancreatic fistulas: Four case reports and review of the literature. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(12), s. 1491–1496. Fulltekst i vitenarkiv
• Labori, Knut Jørgen; TRONDSEN, ERIK; Buanes, Trond & Hauge, Truls (2009). Endoscopic sealing of pancreatic fistulas: Four case reports and review of the literature. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(12), s. 1491–1496. doi: 10.3109/00365520903362610. Fulltekst i vitenarkiv
• Gaarder, C; Naess, PA; Eken, T; Skaga, NO; Pillgram-Larsen, J & Klow, NE [Vis alle 7 forfattere av denne artikkelen] (2007). Liver injuries - Improved results with a formal protocol including angiography. Injury. ISSN 0020-1383. 38, s. 1075–1083. doi: 10.1016/j.injury.2007.02.001. Fulltekst i vitenarkiv
• Buanes, Trond (2005). Svulster i bukspyttkjertel, lever og galleveier. I Kåresen, Rolf & Wist, Erik (Red.), Kreftsykdommer - en basisbok for helsepersonell. Gyldendal Akademisk. ISSN 9788205334946. Fulltekst i vitenarkiv
• Gaarder, C.; Naess, P.A.; Buanes, Trond & Pillgram, Johan Larsen (2005). Advanced surgical trauma care training with a live porcine model. Injury. ISSN 0020-1383. 36(6). Fulltekst i vitenarkiv
• Gaarder, C.; Skaga, Nils Oddvar; Eken, Torsten; Pillgram, Johan Larsen; Buanes, Trond & Næss, Pål Aksel (2005). The impact of patient volume on surgical trauma training in a Scandinavian trauma centre. Injury. ISSN 0020-1383. 36(11), s. 1288–1292. Fulltekst i vitenarkiv
• Myre, Kirsti; Rostrup, Morten; Eriksen, Morten; Buanes, Trond; Ræder, Johan & Stokland, Olav Audun (2004). Increased spillover of norepinephrine to the portal vein during CO2-pneumoperitoneum in pigs. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 48, s. 443–450. Fulltekst i vitenarkiv
• Skattum, Jorunn Pettersen; Edwin, Bjørn; TRONDSEN, ERIK; Mjåland, O.; Ræder, Johan & Buanes, Trond (2004). Outpatient laparoscopic surgery: feasibility and consequences for education and health care costs. Surgical Endoscopy. ISSN 0930-2794. 18(5), s. 796–801. doi: 10.1007/s00464-003-9180-z. Fulltekst i vitenarkiv
• Gaarder, Christine; Næss, Pål Aksel; Schwab, CW; Bjørnbeth, Bjørn Atle; Buanes, Trond & Pillgram, Johan Larsen (2004). "Vac pac" - en god metode for midlertidig bukveggslukking. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 124(21), s. 2710–2712. Fulltekst i vitenarkiv
• Edwin, Bjørn; Mala, Tom; Mathisen, Øystein; Gladhaug, Ivar Prydz; Buanes, Trond & Lunde, O.C. [Vis alle 9 forfattere av denne artikkelen] (2004). Laparoscopic resection of the pancreas: a feasibility study of the short-term outcome. Surgical Endoscopy. ISSN 0930-2794. 18(3), s. 407–411. Fulltekst i vitenarkiv
• Edwin, Bjørn; Skattum, Jorunn Pettersen; Ræder, Johan; TRONDSEN, ERIK & Buanes, Trond (2004). Outpatient laparoscopic splenectomy. Surgical Endoscopy. ISSN 0930-2794. 18(9), s. 1331–1334. Fulltekst i vitenarkiv
• Skattum, Jorunn Pettersen; Edwin, Bjørn; TRONDSEN, ERIK; Mjåland, J; Ræder, Johan & Buanes, Trond (2004). Outpatient laparoscopic surgery: feasibility and consequences for educatin and health care costs. Surgical Endoscopy. ISSN 0930-2794. 18, s. 796–801. Fulltekst i vitenarkiv
• Myre, Kirsti; Ræder, Johan; Rostrup, Morten; Buanes, Trond & Stokland, Olav (2003). Catecholamine release during laparoscopic fundoplication with high and low doses of remifentanil. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 47(3), s. 267–273. Fulltekst i vitenarkiv
• Aanestad, Margunn; Røtnes, Jan Sigurd; Edvin, Bjørn & Buanes, Trond (2002). From operating theatre to operating studio - visualizing surgery in the age of telemedicine. Journal of Telemedicine and Telecare. ISSN 1357-633X. 8(1), s. 56–60. Fulltekst i vitenarkiv Vis sammendrag

  The introduction of communication technology into operating theatres involves significant changes and challenges. We have conducted a telemedicine project between two of Norway¿s largest hospitals (Rikshospitalet and Ullevaal hospital) with a focus on image-guided surgical and radiological procedures. Video was broadcast using a 34 Mbit/s ATM network. This resulted in changes in the local work practice to accommodate and facilitate the communication. It also required changes in the surgeon¿s work situation with regard to teaching in order to improve communication with remote viewers. These changes were non-trivial, and we see them as signs of a shift towards a more public kind of surgery and interventional radiology brought about by the technology.

• Trondsen, Erik; Johannessen, Hans-Olaf; Buanes, Trond & Ræder, Johan (2002). Dagkirurgisk laparoskopisk fundoplikasjon for gastrooesophageal reflukssykdom. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 122, s. 2692–2695. Fulltekst i vitenarkiv

Se alle arbeider i NVA

• Hauge, Truls; Warloe, Trond; Hauge, Petra Weber; Franco-Lie, Isabel; Drolsum, Anders & Johansen, Cathrine Kiperberg [Vis alle 10 forfattere av denne artikkelen] (2012). Photodynamic therapy with temoporfin in combination with gemcitabine/capecitabine in biliary tract cancer: Feasibility and safety in a randomized phase II trial. Journal of Clinical Oncology. ISSN 0732-183X. 30(15). Fulltekst i vitenarkiv
• Hauge, Petra Weber; Hauge, Truls; Warloe, Trond; Franco-Lie, Isabel; Drolsum, Anders & Johansen, Cathrine Kiperberg [Vis alle 10 forfattere av denne artikkelen] (2012). LOCALLY ADVANCED/METASTATIC CHOLANGIOCARCINOMA TREATED WITH STENT, GEMCITABINE/CAPECITABINE PLUS-MINUS PHOTODYNAMIC THERAPY (TEMOPORFIN) - PRELIMINARY RESULTS FROM A NORWEGIAN PHASE II TRIAL. Annals of Oncology. ISSN 0923-7534. 23, s. 56–56. Fulltekst i vitenarkiv
• Fretland, Åsmund Avdem; Kvernebo, Knut; Trondsen, Erik; Bjørnbeth, Bjørn Atle; Labori, Knut Jørgen & Meidel, Nina [Vis alle 7 forfattere av denne artikkelen] (2005). Nekrotiserende pancreatitt - potensielle dødsårsaker. Fulltekst i vitenarkiv
• Digranes, Torstein; Trondsen, Erik; Bjørnbeth, Bjørn Atle; Labori, Knut Jørgen & Buanes, Trond (2005). Histologisk verifikasjon er indisert ved inoperabel pancreascancer. Fulltekst i vitenarkiv
• Labori, Knut Jørgen; Hjermstad, Marianne Jensen; Wester, Torunn; Buanes, Trond & Loge, Jon Håvard (2005). Symptomprofil, livskvalitet og hjelpetiltak ved avansert pankreascancer - en prospektiv studie. Fulltekst i vitenarkiv
• Buanes, Trond; Edwin, B.; Trondsen, E.; Bjørnbeth, B.A.; Rosseland, Arne Retvedt & Mala, Tom (2005). High risk of cancer in cystic and non-cystic pancreativ neoplasms - laparoscopic removal without preoperative biopsy, a key to improved survival. Fulltekst i vitenarkiv
• Trondsen, Erik; Skattum, Jorunn; Labori, Knut Jørgen; Bjørnbeth, Bjørn Atle; Hauge, T. & Buanes, Trond (2005). Intraduktale papillære mucinøse neoplasier (IPMN). Fulltekst i vitenarkiv
• Bernhardt, SL; Buanes, Trond; Moller, M; Eriksen, JA & Geudernack, G (2005). Imiquimod a new adjuvant for telomerase peptide vaccine: A phase I trial in patients with inoperable pancreatic cancer. Journal of Clinical Oncology. ISSN 0732-183X. 23. Fulltekst i vitenarkiv
• Yaqub, Sheraz; Mahic, Milada; Bjørnbeth, Bjørn Atle; Buanes, Trond; Henjum, Karen & Jahnsen, Frode L. [Vis alle 8 forfattere av denne artikkelen] (2005). Adaptive regulatoriske T-celler hemmer anti-tumor immunresponser. Fulltekst i vitenarkiv
• Bjørnbeth, Bjørn Atle; Labori, Knut Jørgen; Buanes, Trond; Tveit, Magne Kjell; Nordeng, Hans Jørgen & Drolsum, Anders [Vis alle 7 forfattere av denne artikkelen] (2005). Onkologisk-kirurgisk poliklinikk. Fulltekst i vitenarkiv
• Gaarder, C.; Skaga, Nils Oddvar; Eken, Torsten; Buanes, Trond & Næss, Pål Aksel (2005). Betydningen av pasientvolum for kirurgisk erfaring med skadebehandling. Fulltekst i vitenarkiv
• Førland, Dag Tidemann; Næss, Pål Aksel; Gaarder, C.; Buanes, Trond & Labori, Knut Jørgen (2005). Pankreastumor påvist etter stump bukskade hos barn. Fulltekst i vitenarkiv
• Digranes, Torstein; Trondsen, Erik; Labori, Knut Jørgen; Buanes, Trond & Bjørnbeth, Bjørn Atle (2005). Penetrerende bukskade i øvre høyre kvadrant. Fulltekst i vitenarkiv
• Bjørnbeth, Bjørn Atle; Labori, Knut Jørgen; Buanes, Trond & Carlsen, Erik (2005). Resultater for drift av onkologisk-kirurgisk poliklinikk. Fulltekst i vitenarkiv
• Buanes, Trond; Skattum, Jorunn Pettersen; TRONDSEN, ERIK & Bjørnbeth, Bjørn Atle (2004). Konsekvenser av ambulant laparoskopisk kirurgi for driftskostnader og organisering av sykehusavdelinger. Fulltekst i vitenarkiv
• Røtnes, Jan Sigurd; Sørhus, Vidar; Edwin, Bjørn; Buanes, Trond; Fosse, Erik & Rosseland, Arne Retvedt (2004). Etablering av en utdanningsplattform for laparoskopisk kirurgi. Fulltekst i vitenarkiv
• Bernhardt, Synne L. S.; Gjertsen, Marianne K.; Moeller, Mona; Eriksen, Jon Amund; Soereide, Odd & Gladhaug, Ivar [Vis alle 9 forfattere av denne artikkelen] (2004). Ras Peptide Vaccination in Resected Pancreatic Cancer. Patients: Safety, Immune Response and Survival. Fulltekst i vitenarkiv
• Buanes, Trond; Bernhardt, Synne L. S. & Geitung, JT (2004). Radiologisk staging og kirurgisk behandling av pancreascancer. Fulltekst i vitenarkiv
• Buanes, Trond (2003). Behandling av pancreaspasienter. Fulltekst i vitenarkiv
• Gaarder, C.; Næss, P.A.; Pillgram-Larsen, J. & Buanes, Trond (2003). Nye aspekter ved behandling av lever- og miltskader. Fulltekst i vitenarkiv
• Gaarder, C.; Næss, P.A.; Pillgram-Larsen, J.; Bjørnbeth, B.A. & Buanes, Trond (2003). "VAC PAC" - God metode for å legge abdomen åpen? Fulltekst i vitenarkiv
• Skattum, Jorunn; Edvin, Bjørn; Trondsen, Erik & Buanes, Trond (2003). Laparoskopisk dagkirurgi - konsekvenser for paseint, utdanning og økonomi. Fulltekst i vitenarkiv
• Edvin, Bjørn; Skattum, Jorunn; Ræder, Johan; Trondsen, Erik & Buanes, Trond (2003). Laparoskopisk splenectomi som dagkirurgi. Fulltekst i vitenarkiv
• Digranes, Torstein; Trondsen, Erik & Buanes, Trond (2003). Tuberkuløs peritonitt - laparoskopisk diagnostikk (video). Fulltekst i vitenarkiv
• Trondsen, Erik; Gondal, Ghous; Bjørnbeth, Bjørn Atle & Buanes, Trond (2003). Laparoskopisk operasjon for ventralhernie. Fulltekst i vitenarkiv
• Edvin, Bjørn; Mala, Tom; Mathisen, Øystein; Rosseland, Arne Retvedt; Buanes, Trond & Trondsen, Erik [Vis alle 11 forfattere av denne artikkelen] (2003). Laparoskopisk pancreaskirurgi. Fulltekst i vitenarkiv
• Gaudernack, Gustav; Buanes, Trond; Meo, Axel Marco; Aamdal, Steinar; Brunsvig, P. & Braathen, L.R. [Vis alle 10 forfattere av denne artikkelen] (2003). Clinical trials of a peptide based vaccine targeting telomerase. Fulltekst i vitenarkiv
• Bjørnbeth, Bjørn Atle; Trondsen, Erik & Buanes, Trond (2003). To pasienter med tumor i øvre høyre kvadrant med uventet histologi. Fulltekst i vitenarkiv
• Edvin, Bjørn; Trondsen, Erik; Skattum, Jorunn & Buanes, Trond (2003). Outpatient laparoscopic splenectomy - patient safety and satisfaction. Fulltekst i vitenarkiv
• Trondsen, Erik & Buanes, Trond (2003). Outpatient laparoscopic fundoplication for gastroesophageal reflux disease. Fulltekst i vitenarkiv
• Buanes, Trond (2003). Behandling av pancreascancer. Fulltekst i vitenarkiv
• Edvin, Bjørn; Trondsen, Erik; Bjørnbeth, Bjørn Atle & Buanes, Trond (2003). Kirurgisk teknikk ved laparoskopisk resekjon av corpus/cauda pancreatis med splenectomi ved adenocarcinom, oppstått ved kronisk pancreatitt (video). Fulltekst i vitenarkiv
• Trondsen, Erik; Edvin, Bjørn; Bjørnbeth, Bjørn Atle & Buanes, Trond (2003). Kirurgisk teknikk ved laparoskopisk reseksjon av corpus/cauda pancreatis med splenectomi ved Gruber-Frantz tumor (video). Fulltekst i vitenarkiv
• Bernhardt, Synne L. S.; Gaudernack, Gustav; Gjertsen, Marianne Klemp; Møller, Mona; Eriksen, Jon Amund & Baksaas, Ingebjørg [Vis alle 8 forfattere av denne artikkelen] (2003). Telomerase immunstimulering - klinisk og immunologisk respons hos pasienter med inoperabel pancreascancer. Fulltekst i vitenarkiv
• Buanes, Trond; Trondsen, Erik; Bjørnbeth, Bjørn Atle & Edvin, Bjørn (2003). Prognose og behandling ved mucinøse tumores i pancreas (pancreatic intraductal papillary mucinous neoplasms = IPMNs. Fulltekst i vitenarkiv
• Buanes, Trond (2003). The potential of laparoscopic surgery on an outpatient basis. Fulltekst i vitenarkiv
• Buanes, Trond; Gaudernack, Gustav; Eriksen, Jon Amund & Møller, Mona (2003). Peptid-basert vaksine mot telomerase -nyttig for pasienter? Fulltekst i vitenarkiv
• Edvin, Bjørn; Mala, Tom; Mathisen, Øystein; Buanes, Trond; Lunde, Ole Christian & Gladhaug, Ivar [Vis alle 8 forfattere av denne artikkelen] (2002). Laparoskopisk pancreaskirurgi. Fulltekst i vitenarkiv
• Gaarder, C.; Bjørnbeth, Bjørn Atle; Wessel, Nicolai; Pillgram-Larsen, Johan & Buanes, Trond (2002). Stumpe Abdominalskader: En diagnostikk i utfordring. Fulltekst i vitenarkiv
• Bjørnbeth, Bjørn Atle; Buanes, Trond & Ræder, Morten (2002). Radiofrekvens ablasjon som behandling for levermetastaser. Fulltekst i vitenarkiv
• Bjørnbeth, Bjørn Atle; Ræder, Morten; Noreng, H.J.; Geitung, Jonn Terje & Buanes, Trond (2002). Preoperativ operabilitetsutredning av levermetastaser fa colorectal cancer med MRI med leverspesifisert kontrastmiddel (Teslascan = MNDPDP). Fulltekst i vitenarkiv
• Gaarder, C.; Kløw, Nils-Einar & Buanes, Trond (2002). Embolisering som ledd i ikke-operativ behandling av alvorlig leverskade. Fulltekst i vitenarkiv
• Myre, Kirsti; Eriksen, M.; Ræder, Johan; Rostrup, Morten; Buanes, Trond & Stokland, Olav Audun (2004). Increased spillover of norepinephrine to the portal vein during CO2-pneumoperitoneum in pigs. Universitetet i Oslo. Fulltekst i vitenarkiv

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